psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F5	R:R:Y6	15.47	Yes	Yes	1	4	6
2	R:R:F5	R:R:V188	3.93	Yes	No	0	4	3
3	R:R:E295	R:R:F5	7	No	Yes	0	1	4
4	R:R:F5	R:R:R298	5.34	Yes	No	1	4	1
5	R:R:E301	R:R:F5	3.5	Yes	Yes	1	3	4
6	R:R:E302	R:R:F5	10.49	Yes	Yes	1	3	4
7	R:R:V175	R:R:Y6	10.09	No	Yes	1	4	6
8	R:R:Y177	R:R:Y6	7.94	Yes	Yes	1	9	6
9	R:R:Q186	R:R:Y6	4.51	Yes	Yes	1	5	6
10	R:R:E302	R:R:Y6	5.61	Yes	Yes	1	3	6
11	R:R:E15	R:R:R7	4.65	No	No	0	3	4
12	R:R:C178	R:R:R7	4.18	No	No	0	4	4
13	R:R:R298	R:R:R7	9.6	No	No	0	1	4
14	R:R:C8	R:R:T11	8.45	No	No	4	9	4
15	R:R:C8	R:R:E15	4.56	No	No	4	9	3
16	R:R:N10	R:R:Q9	7.92	No	No	0	6	2
17	R:R:N10	R:R:R94	6.03	No	No	0	6	2
18	R:R:E15	R:R:T11	4.23	No	No	4	3	4
19	R:R:T12	R:R:V95	7.93	No	No	0	5	2
20	R:R:T181	R:R:V14	3.17	Yes	No	0	9	4
21	R:R:K16	R:R:N90	4.2	No	No	0	1	5
22	R:R:N18	R:R:Y87	5.81	No	Yes	0	3	8
23	R:R:S19	R:R:V21	6.46	No	No	0	6	3
24	R:R:A20	R:R:Y87	5.34	No	Yes	0	6	8
25	R:R:M22	R:R:R310	8.69	No	Yes	0	3	9
26	L:L:?1	R:R:G23	3.49	Yes	No	0	0	8
27	R:R:F27	R:R:L31	4.87	Yes	No	0	8	6
28	R:R:F27	R:R:K76	3.72	Yes	No	0	8	8
29	R:R:F27	R:R:S80	15.85	Yes	Yes	0	8	8
30	R:R:G30	R:R:I317	7.05	No	Yes	0	9	9
31	R:R:L31	R:R:L35	6.92	No	No	0	6	5
32	R:R:D72	R:R:N34	6.73	Yes	No	0	9	9
33	R:R:L73	R:R:N34	6.87	No	No	0	8	9
34	R:R:N34	R:R:P320	4.89	No	No	0	9	9
35	R:R:A37	R:R:I324	3.25	No	Yes	0	9	9
36	R:R:I324	R:R:L40	4.28	Yes	No	0	9	8
37	R:R:L40	R:R:S328	6.01	No	No	0	8	7
38	R:R:L41	R:R:Y62	5.86	No	No	0	9	7
39	R:R:C66	R:R:L41	3.17	No	No	0	6	9
40	R:R:I324	R:R:L41	4.28	Yes	No	0	9	9
41	R:R:P56	R:R:S44	8.91	No	No	0	3	7
42	R:R:L57	R:R:P58	3.28	No	No	0	7	6
43	R:R:L146	R:R:P58	3.28	No	No	0	4	6
44	R:R:E129	R:R:V60	4.28	No	Yes	0	9	7
45	R:R:I144	R:R:V60	4.61	No	Yes	0	5	7
46	R:R:F61	R:R:V65	7.87	No	No	5	9	8
47	R:R:F61	R:R:M126	3.73	No	Yes	5	9	9
48	R:R:L146	R:R:M63	4.24	No	No	0	4	6
49	R:R:A150	R:R:M63	3.22	No	No	0	5	6
50	R:R:L64	R:R:M126	5.65	No	Yes	0	8	9
51	R:R:M126	R:R:V65	4.56	Yes	No	5	9	8
52	R:R:D72	R:R:L68	8.14	Yes	Yes	3	9	9
53	R:R:L68	R:R:Q122	6.65	Yes	No	0	9	7
54	R:R:L123	R:R:L68	5.54	No	Yes	3	8	9
55	R:R:D319	R:R:L68	6.79	Yes	Yes	3	9	9
56	R:R:S118	R:R:T71	4.8	No	No	0	7	9
57	R:R:Q122	R:R:T71	7.09	No	No	0	7	9
58	R:R:D72	R:R:S119	4.42	Yes	No	0	9	8
59	R:R:D72	R:R:S316	10.31	Yes	No	0	9	8
60	R:R:D319	R:R:D72	3.99	Yes	Yes	3	9	9
61	R:R:C77	R:R:L73	3.17	No	No	0	6	8
62	R:R:F115	R:R:G75	9.03	Yes	No	0	8	9
63	L:L:?1	R:R:K76	11.52	Yes	No	0	0	8
64	R:R:F108	R:R:L79	8.53	Yes	No	1	6	6
65	R:R:L79	R:R:M112	4.24	No	Yes	1	6	8
66	L:L:?1	R:R:L79	11.3	Yes	No	1	0	6
67	R:R:P81	R:R:S80	3.56	No	Yes	0	8	8
68	L:L:?1	R:R:S80	10.22	Yes	Yes	0	0	8
69	R:R:L104	R:R:V82	5.96	No	No	0	5	6
70	R:R:F108	R:R:V82	5.24	Yes	No	0	6	6
71	R:R:F108	R:R:V83	3.93	Yes	No	0	6	9
72	R:R:T181	R:R:V83	4.76	Yes	No	0	9	9
73	L:L:?1	R:R:V83	8.11	Yes	No	0	0	9
74	R:R:A86	R:R:T181	3.36	No	Yes	0	6	9
75	R:R:T181	R:R:Y87	19.97	Yes	Yes	0	9	8
76	L:L:?1	R:R:Y87	4.79	Yes	Yes	0	0	8
77	R:R:A88	R:R:Q89	4.55	No	No	0	5	5
78	R:R:Q89	R:R:R91	7.01	No	No	0	5	3
79	R:R:S92	R:R:V95	4.85	No	No	0	5	2
80	R:R:Q176	R:R:S92	7.22	No	No	0	5	5
81	R:R:F108	R:R:L93	4.87	Yes	No	0	6	6
82	R:R:C183	R:R:L93	4.76	No	No	0	9	6
83	R:R:L100	R:R:S103	10.51	No	No	0	4	3
84	R:R:D101	R:R:N102	9.42	No	No	0	4	1
85	R:R:C105	R:R:C183	5.46	No	No	0	9	9
86	R:R:F174	R:R:Q106	5.86	Yes	No	0	6	4
87	R:R:F108	R:R:M112	3.73	Yes	Yes	1	6	8
88	R:R:A109	R:R:F174	9.71	No	Yes	0	8	6
89	R:R:F110	R:R:F168	10.72	No	No	0	7	4
90	R:R:F111	R:R:F115	3.22	No	Yes	6	5	8
91	R:R:F184	R:R:M112	6.22	Yes	Yes	1	8	8
92	L:L:?1	R:R:M112	8.66	Yes	Yes	1	0	8
93	R:R:F184	R:R:S113	3.96	Yes	No	0	8	7
94	R:R:S113	R:R:Y203	3.82	No	Yes	0	7	8
95	R:R:F114	R:R:F115	15	Yes	Yes	0	7	8
96	R:R:F114	R:R:S160	3.96	Yes	No	0	7	7
97	R:R:F114	R:R:L161	7.31	Yes	No	0	7	3
98	R:R:L117	R:R:L121	5.54	Yes	Yes	0	8	5
99	R:R:L117	R:R:S160	6.01	Yes	No	0	8	7
100	R:R:F163	R:R:L117	3.65	Yes	Yes	2	7	8
101	R:R:L117	R:R:L206	5.54	Yes	No	2	8	5
102	R:R:S118	R:R:S160	3.26	No	No	0	7	7
103	R:R:M207	R:R:T120	7.53	No	No	0	7	7
104	R:R:L210	R:R:T120	5.9	Yes	No	0	6	7
105	R:R:F274	R:R:T120	5.19	Yes	No	0	9	7
106	R:R:L121	R:R:V156	7.45	Yes	No	0	5	6
107	R:R:L121	R:R:L210	5.54	Yes	Yes	0	5	6
108	R:R:F274	R:R:L123	4.87	Yes	No	3	9	8
109	R:R:D319	R:R:L123	8.14	Yes	No	3	9	8
110	R:R:L124	R:R:L210	4.15	No	Yes	0	5	6
111	R:R:A213	R:R:L124	4.73	No	No	0	6	5
112	R:R:L124	R:R:T214	5.9	No	No	0	5	8
113	R:R:F323	R:R:M126	4.98	No	Yes	0	9	9
114	R:R:L128	R:R:L132	5.54	No	No	0	7	5
115	R:R:C217	R:R:L128	3.17	No	No	0	7	7
116	R:R:E129	R:R:Y140	7.86	No	No	0	9	8
117	R:R:C130	R:R:L134	3.17	No	No	0	9	8
118	R:R:L132	R:R:W131	5.69	No	No	0	5	6
119	R:R:H136	R:R:W131	8.46	No	No	0	4	6
120	R:R:F139	R:R:L132	3.65	No	No	0	5	5
121	R:R:S133	R:R:Y140	13.99	No	No	0	9	8
122	R:R:L134	R:R:L225	5.54	No	Yes	7	8	9
123	R:R:G135	R:R:H136	3.18	No	No	0	7	4
124	R:R:G135	R:R:N224	5.09	No	No	0	7	7
125	R:R:F139	R:R:H143	16.97	No	No	0	5	5
126	R:R:I144	R:R:Y140	10.88	No	No	0	5	8
127	R:R:H143	R:R:R142	5.64	No	No	0	5	5
128	R:R:R147	R:R:T145	3.88	No	No	0	4	6
129	R:R:L151	R:R:R147	6.07	No	No	0	3	4
130	R:R:F163	R:R:Y199	4.13	Yes	Yes	2	7	6
131	R:R:F163	R:R:L202	6.09	Yes	No	0	7	5
132	R:R:F163	R:R:Y203	4.13	Yes	Yes	0	7	8
133	R:R:F163	R:R:L206	4.87	Yes	No	2	7	5
134	R:R:F171	R:R:L166	3.65	No	No	2	4	7
135	R:R:L166	R:R:Y199	5.86	No	Yes	2	7	6
136	R:R:G172	R:R:P167	4.06	No	No	2	8	9
137	R:R:F174	R:R:P167	8.67	Yes	No	0	6	9
138	R:R:P167	R:R:Y199	13.91	No	Yes	2	9	6
139	R:R:F168	R:R:F174	4.29	No	Yes	0	4	6
140	R:R:F171	R:R:Y199	9.28	No	Yes	2	4	6
141	R:R:G172	R:R:Y199	4.35	No	Yes	2	8	6
142	R:R:K173	R:R:Q186	8.14	No	Yes	1	2	5
143	R:R:K173	R:R:V196	7.59	No	No	1	2	5
144	R:R:F174	R:R:I185	5.02	Yes	Yes	0	6	7
145	R:R:Q186	R:R:V175	8.6	Yes	No	1	5	4
146	R:R:G180	R:R:Q176	6.58	No	No	0	6	5
147	R:R:C183	R:R:Q176	4.58	No	No	0	9	5
148	R:R:W182	R:R:Y177	25.08	Yes	Yes	1	9	9
149	R:R:F184	R:R:Y177	5.16	Yes	Yes	1	8	9
150	R:R:M187	R:R:Y177	3.59	No	Yes	1	7	9
151	R:R:E302	R:R:Y177	5.61	Yes	Yes	1	3	9
152	R:R:D305	R:R:Y177	5.75	No	Yes	0	7	9
153	R:R:C178	R:R:E302	6.08	No	Yes	0	4	3
154	R:R:P179	R:R:W182	6.76	No	Yes	1	8	9
155	R:R:L306	R:R:P179	4.93	No	No	1	7	8
156	R:R:L306	R:R:W182	5.69	No	Yes	1	7	9
157	R:R:L309	R:R:W182	4.56	No	Yes	0	7	9
158	L:L:?1	R:R:W182	10.85	Yes	Yes	1	0	9
159	R:R:F184	R:R:I185	7.54	Yes	Yes	0	8	7
160	R:R:F184	R:R:M187	3.73	Yes	No	1	8	7
161	R:R:F184	R:R:L309	6.09	Yes	No	0	8	7
162	R:R:I185	R:R:Y199	9.67	Yes	Yes	0	7	6
163	R:R:I185	R:R:S200	4.64	Yes	No	0	7	7
164	R:R:I185	R:R:Y203	4.84	Yes	Yes	0	7	8
165	R:R:H189	R:R:Q186	3.71	Yes	Yes	1	4	5
166	R:R:Q186	R:R:V196	8.6	Yes	No	1	5	5
167	R:R:G288	R:R:V188	5.52	No	No	0	7	3
168	R:R:E191	R:R:H189	12.31	No	Yes	1	1	4
169	R:R:G192	R:R:H189	4.77	No	Yes	1	1	4
170	R:R:H189	R:R:S193	8.37	Yes	Yes	1	4	3
171	R:R:E191	R:R:G192	3.27	No	No	1	1	1
172	R:R:E191	R:R:S193	5.75	No	Yes	1	1	3
173	R:R:S193	R:R:S195	4.89	Yes	No	0	3	1
174	R:R:S193	R:R:V196	6.46	Yes	No	1	3	5
175	R:R:F290	R:R:V201	5.24	No	No	0	3	4
176	R:R:M207	R:R:Y203	10.78	No	Yes	0	7	8
177	R:R:I282	R:R:S204	4.64	Yes	No	8	8	8
178	R:R:A285	R:R:S204	3.42	No	No	0	7	8
179	R:R:S204	R:R:Y286	13.99	No	No	8	8	5
180	R:R:S205	R:R:Y286	5.09	No	No	0	4	5
181	R:R:L206	R:R:L210	6.92	No	Yes	0	5	6
182	R:R:A208	R:R:I282	3.25	No	Yes	0	6	8
183	R:R:F274	R:R:V211	7.87	Yes	No	3	9	8
184	R:R:S278	R:R:V211	3.23	No	No	3	9	8
185	R:R:L212	R:R:L216	4.15	No	No	0	3	4
186	R:R:N218	R:R:T214	4.39	No	No	0	9	8
187	R:R:T271	R:R:V215	4.76	No	No	0	8	6
188	R:R:N218	R:R:T271	13.16	No	No	0	9	8
189	R:R:L264	R:R:M222	7.07	No	No	0	7	7
190	R:R:L225	R:R:L264	4.15	Yes	No	0	9	7
191	R:R:R230	R:R:Y226	14.4	No	No	0	5	5
192	R:R:M228	R:R:R231	3.72	No	No	0	8	5
193	R:R:H229	R:R:Q233	13.6	No	No	0	6	3
194	R:R:E260	R:R:H229	12.31	Yes	No	0	9	6
195	R:R:H229	R:R:L261	16.71	No	No	0	6	5
196	R:R:R231	R:R:R234	4.26	No	No	0	5	3
197	R:R:E260	R:R:L232	7.95	Yes	No	0	9	5
198	R:R:H235	R:R:P236	21.35	No	No	0	4	4
199	R:R:Q256	R:R:R332	8.18	No	No	0	5	6
200	R:R:D262	R:R:L258	9.5	No	No	9	9	6
201	R:R:H263	R:R:L258	9	No	No	9	8	6
202	R:R:L258	R:R:R332	9.72	No	No	0	6	6
203	R:R:D262	R:R:E259	3.9	No	No	0	9	6
204	R:R:D262	R:R:H263	8.82	No	No	9	9	8
205	R:R:H263	R:R:R327	7.9	No	No	0	8	9
206	R:R:L266	R:R:R327	7.29	No	No	0	8	9
207	R:R:I322	R:R:M270	5.83	Yes	No	0	8	9
208	R:R:F323	R:R:M270	7.46	No	No	0	9	9
209	R:R:L273	R:R:V318	5.96	No	No	0	8	8
210	R:R:F274	R:R:S278	9.25	Yes	No	3	9	9
211	R:R:F274	R:R:I315	5.02	Yes	No	0	9	9
212	R:R:M276	R:R:T275	4.52	No	No	0	5	5
213	R:R:C277	R:R:V314	3.42	No	No	0	9	4
214	R:R:C277	R:R:I315	4.91	No	No	0	9	9
215	R:R:L312	R:R:V281	4.47	No	No	0	8	8
216	R:R:I282	R:R:Y286	4.84	Yes	No	8	8	5
217	R:R:E301	R:R:R284	12.79	Yes	No	1	3	5
218	R:R:E304	R:R:R284	17.45	No	No	1	1	5
219	R:R:D305	R:R:R284	13.1	No	No	0	7	5
220	R:R:K291	R:R:Y287	7.17	No	Yes	0	3	4
221	R:R:D292	R:R:Y287	8.05	Yes	Yes	1	2	4
222	R:R:E301	R:R:Y287	5.61	Yes	Yes	1	3	4
223	R:R:A289	R:R:F290	8.32	No	No	0	7	3
224	R:R:D292	R:R:E295	9.09	Yes	No	0	2	1
225	R:R:D292	R:R:E301	6.5	Yes	Yes	1	2	3
226	R:R:K294	R:R:K296	4.31	No	No	0	1	1
227	R:R:N297	R:R:T299	4.39	No	No	0	3	1
228	R:R:N297	R:R:S300	4.47	No	No	0	3	1
229	R:R:E302	R:R:R298	4.65	Yes	No	1	3	1
230	R:R:E304	R:R:S300	4.31	No	No	0	1	1
231	R:R:E301	R:R:E304	3.81	Yes	No	1	3	1
232	R:R:L306	R:R:R310	14.58	No	Yes	0	7	9
233	R:R:R307	R:R:R310	3.2	No	Yes	0	4	9
234	R:R:F311	R:R:R307	5.34	No	No	0	6	4
235	L:L:?1	R:R:R310	9.92	Yes	Yes	0	0	9
236	L:L:?1	R:R:L312	3.77	Yes	No	0	0	8
237	L:L:?1	R:R:S313	10.22	Yes	No	0	0	9
238	R:R:D319	R:R:I315	4.2	Yes	No	0	9	9
239	R:R:D319	R:R:F323	7.17	Yes	No	0	9	9
240	R:R:I325	R:R:W321	15.27	No	No	0	8	8
241	R:R:F326	R:R:W321	5.01	No	No	0	5	8
242	R:R:F326	R:R:I322	5.02	No	Yes	0	5	8
243	R:R:F331	R:R:I325	6.28	No	No	0	7	8
244	R:R:F326	R:R:F331	5.36	No	No	0	5	7
245	R:R:P329	R:R:S328	3.56	No	No	0	7	7
246	R:R:S328	R:R:V330	3.23	No	No	0	7	7
247	R:R:P329	R:R:R332	5.76	No	No	0	7	6
248	R:R:F331	R:R:F335	9.65	No	No	0	7	4
249	R:R:F334	R:R:I333	3.77	No	No	0	4	5
250	R:R:P257	R:R:Q256	3.16	No	No	0	6	5
251	R:R:A85	R:R:L96	3.15	No	No	0	6	4
252	R:R:A97	R:R:L100	3.15	No	No	0	1	4
253	R:R:A289	R:R:L197	3.15	No	No	0	7	4
254	R:R:A127	R:R:N218	3.13	No	No	0	9	9
255	R:R:I324	R:R:V65	3.07	Yes	No	0	9	8
256	R:R:I322	R:R:V318	3.07	Yes	No	0	8	8
257	R:R:I317	R:R:T29	3.04	Yes	No	0	9	6
258	R:R:F171	R:R:G198	3.01	No	No	0	4	4
259	R:R:L84	R:R:S80	3	No	Yes	0	7	8
260	R:R:L64	R:R:V60	2.98	No	Yes	0	8	7
261	R:R:L64	R:R:V152	2.98	No	No	0	8	5
262	R:R:L219	R:R:V215	2.98	No	No	0	5	6
263	R:R:Y283	R:R:Y287	2.98	No	Yes	0	6	4
264	R:R:L38	R:R:T69	2.95	No	No	0	7	8
265	R:R:I282	R:R:M207	2.92	Yes	No	0	8	7
266	R:R:I317	R:R:K76	2.91	Yes	No	0	9	8
267	R:R:I317	R:R:L26	2.85	Yes	No	0	9	8
268	R:R:I325	R:R:L36	2.85	No	No	0	8	5
269	R:R:G220	R:R:W131	2.81	No	No	0	5	6
270	R:R:C105	R:R:R94	2.79	No	No	0	9	2
271	R:R:C164	R:R:F110	2.79	No	No	0	8	7
272	R:R:C164	R:R:F114	2.79	No	Yes	0	8	7
273	R:R:L104	R:R:L96	2.77	No	No	0	5	4
274	R:R:D292	R:R:K296	2.77	Yes	No	0	2	1
275	R:R:L96	R:R:Q89	2.66	No	No	0	4	5
276	R:R:E260	R:R:L225	2.65	Yes	Yes	0	9	9
277	R:R:S44	R:R:Y62	2.54	No	No	0	7	7
278	R:R:S59	R:R:Y62	2.54	No	No	0	7	7
279	R:R:E259	R:R:E260	2.54	No	Yes	0	6	9
280	R:R:F139	R:R:I144	2.51	No	No	0	5	5
281	R:R:F290	R:R:K291	2.48	No	No	0	3	3
282	R:R:E190	R:R:H189	2.46	No	Yes	0	1	4
283	R:R:F115	R:R:L74	2.44	Yes	No	0	8	4
284	R:R:F111	R:R:L78	2.44	No	No	6	5	6
285	R:R:F115	R:R:L78	2.44	Yes	No	6	8	6
286	R:R:F159	R:R:L121	2.44	No	Yes	0	4	5
287	R:R:N224	R:R:R223	2.41	No	No	0	7	4
288	R:R:Q233	R:R:R230	2.34	No	No	0	3	5
289	L:L:?1	R:R:G116	2.33	Yes	No	0	0	8
290	R:R:G23	R:R:G24	2.11	No	No	0	8	4
291	R:R:G33	R:R:P320	2.03	No	No	0	9	9
292	R:R:G135	R:R:P137	2.03	No	No	0	7	9
293	R:R:C66	R:R:G67	1.96	No	No	0	6	6
294	R:R:A42	R:R:G39	1.95	No	No	0	4	3
295	R:R:A97	R:R:P98	1.87	No	No	0	1	5
296	R:R:A153	R:R:P154	1.87	No	No	0	7	4
297	R:R:A308	R:R:P280	1.87	No	No	0	7	9
298	R:R:G45	R:R:S44	1.86	No	No	0	6	7
299	R:R:G149	R:R:V60	1.84	No	Yes	0	7	7
300	R:R:G67	R:R:V70	1.84	No	No	0	6	5
301	R:R:A221	R:R:C130	1.81	No	No	0	9	9
302	R:R:P4	R:R:S3	1.78	No	No	0	6	6
303	R:R:G17	R:R:K16	1.74	No	No	0	3	1
304	R:R:G33	R:R:L32	1.71	No	No	0	9	4
305	R:R:G47	R:R:L46	1.71	No	No	0	5	4
306	R:R:A107	R:R:S103	1.71	No	No	0	5	3
307	R:R:G149	R:R:L148	1.71	No	No	0	7	5
308	R:R:G17	R:R:N18	1.7	No	No	0	3	3
309	R:R:A125	R:R:V152	1.7	No	No	0	7	5
310	R:R:A308	R:R:V281	1.7	No	No	0	7	8
311	R:R:A37	R:R:T69	1.68	No	No	0	9	8
312	R:R:L279	R:R:P280	1.64	No	No	0	7	9
313	R:R:A165	R:R:M169	1.61	No	No	0	5	3
314	R:R:A268	R:R:M222	1.61	No	No	0	6	7
315	R:R:S13	R:R:T12	1.6	No	No	0	1	5
316	R:R:T29	R:R:V25	1.59	No	No	0	6	4
317	R:R:T275	R:R:V211	1.59	No	No	0	5	8
318	R:R:T275	R:R:V215	1.59	No	No	0	5	6
319	R:R:A97	R:R:L104	1.58	No	No	0	1	5
320	R:R:A221	R:R:L267	1.58	No	No	0	9	9
321	R:R:M276	R:R:V272	1.52	No	No	0	5	5
322	R:R:L146	R:R:V60	1.49	No	Yes	0	4	7
323	R:R:L151	R:R:V155	1.49	No	No	0	3	3
324	R:R:I322	R:R:L269	1.43	Yes	No	0	8	5
325	R:R:L134	R:R:M228	1.41	No	No	7	8	8
326	R:R:L166	R:R:M169	1.41	No	No	0	7	3
327	R:R:L225	R:R:M228	1.41	Yes	No	7	9	8
328	R:R:A227	R:R:R231	1.38	No	No	0	4	5
329	R:R:I333	R:R:Q256	1.37	No	No	0	5	5
330	R:R:F27	R:R:S28	1.32	Yes	No	0	8	4
331	R:R:F114	R:R:S157	1.32	Yes	No	0	7	6
332	R:R:N102	R:R:R94	1.21	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F5	7.62167	6	1	4
2	R:R:Y6	8.724	5	1	6
3	R:R:F27	6.44	4	0	8
4	R:R:V60	3.04	5	0	7
5	R:R:L68	6.78	4	3	9
6	R:R:D72	6.718	5	3	9
7	R:R:S80	8.1575	4	0	8
8	R:R:Y87	8.9775	4	0	8
9	R:R:F108	5.26	5	1	6
10	R:R:M112	5.7125	4	1	8
11	R:R:F114	6.076	5	0	7
12	R:R:F115	6.426	5	6	8
13	R:R:L117	5.185	4	2	8
14	R:R:L121	5.2425	4	0	5
15	R:R:M126	4.73	4	5	9
16	R:R:F163	4.574	5	2	7
17	R:R:F174	6.71	5	0	6
18	R:R:Y177	8.855	6	1	9
19	R:R:T181	7.815	4	0	9
20	R:R:W182	10.588	5	1	9
21	R:R:F184	5.45	6	1	8
22	R:R:I185	6.342	5	0	7
23	R:R:Q186	6.712	5	1	5
24	R:R:H189	6.324	5	1	4
25	R:R:S193	6.3675	4	1	3
26	R:R:Y199	7.86667	6	2	6
27	R:R:Y203	5.8925	4	0	8
28	R:R:L210	5.6275	4	0	6
29	R:R:L225	3.4375	4	7	9
30	R:R:E260	6.3625	4	0	9
31	R:R:F274	6.44	5	3	9
32	R:R:I282	3.9125	4	8	8
33	R:R:Y287	5.9525	4	1	4
34	R:R:D292	6.6025	4	1	2
35	R:R:E301	6.442	5	1	3
36	R:R:E302	6.488	5	1	3
37	R:R:R310	9.0975	4	0	9
38	R:R:I317	3.9625	4	0	9
39	R:R:D319	6.058	5	3	9
40	R:R:I322	3.8375	4	0	8
41	R:R:I324	3.72	4	0	9
42	L:L:?1	7.93167	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F5	R:R:Y6	14.2107	15.47	Yes	Yes	1	4	6
2	R:R:Y177	R:R:Y6	23.7991	7.94	Yes	Yes	1	9	6
3	R:R:E302	R:R:F5	13.86	10.49	Yes	Yes	1	3	4
4	R:R:E302	R:R:Y177	22.3301	5.61	Yes	Yes	1	3	9
5	R:R:F184	R:R:Y177	57.0478	5.16	Yes	Yes	1	8	9
6	R:R:F184	R:R:M112	54.6149	6.22	Yes	Yes	1	8	8
7	R:R:F108	R:R:M112	24.5871	3.73	Yes	Yes	1	6	8
8	R:R:F108	R:R:L93	13.0393	4.87	Yes	No	0	6	6
9	R:R:C183	R:R:L93	12.1633	4.76	No	No	0	9	6
10	R:R:F274	R:R:L123	51.3613	4.87	Yes	No	3	9	8
11	R:R:F274	R:R:T120	100	5.19	Yes	No	0	9	7
12	R:R:M207	R:R:T120	97.0575	7.53	No	No	0	7	7
13	R:R:M207	R:R:Y203	98.0519	10.78	No	Yes	0	7	8
14	R:R:S113	R:R:Y203	50.6015	3.82	No	Yes	0	7	8
15	R:R:F184	R:R:S113	50.4572	3.96	Yes	No	0	8	7
16	R:R:D319	R:R:L123	46.1551	8.14	Yes	No	3	9	8
17	R:R:D319	R:R:I315	46.3941	4.2	Yes	No	0	9	9
18	R:R:F274	R:R:I315	47.4053	5.02	Yes	No	0	9	9
19	R:R:I185	R:R:Y203	54.5969	4.84	Yes	Yes	0	7	8
20	R:R:F184	R:R:I185	59.7502	7.54	Yes	Yes	0	8	7
21	R:R:I324	R:R:V65	45.5993	3.07	Yes	No	0	9	8
22	R:R:M126	R:R:V65	46.4775	4.56	Yes	No	5	9	8
23	R:R:F323	R:R:M126	74.6733	4.98	No	Yes	0	9	9
24	R:R:D319	R:R:F323	86.3181	7.17	Yes	No	0	9	9
25	R:R:I324	R:R:L40	33.357	4.28	Yes	No	0	9	8
26	R:R:L40	R:R:S328	32.3942	6.01	No	No	0	8	7
27	R:R:L64	R:R:M126	29.6784	5.65	No	Yes	0	8	9
28	R:R:L64	R:R:V60	26.7731	2.98	No	Yes	0	8	7
29	R:R:I144	R:R:V60	16.0968	4.61	No	Yes	0	5	7
30	R:R:F163	R:R:Y203	12.6233	4.13	Yes	Yes	0	7	8
31	R:R:F108	R:R:V82	11.2411	5.24	Yes	No	0	6	6
32	R:R:L104	R:R:V82	10.3167	5.96	No	No	0	5	6
33	R:R:F139	R:R:I144	13.2186	2.51	No	No	0	5	5
34	R:R:F139	R:R:L132	10.2017	3.65	No	No	0	5	5
35	R:R:E260	R:R:L225	12.1306	2.65	Yes	Yes	0	9	9
36	R:R:E259	R:R:E260	18.9299	2.54	No	Yes	0	6	9
37	R:R:D262	R:R:E259	19.9186	3.9	No	No	0	9	6
38	R:R:D262	R:R:L258	20.8374	9.5	No	No	9	9	6
39	R:R:L258	R:R:R332	24.737	9.72	No	No	0	6	6
40	R:R:P329	R:R:R332	29.5092	5.76	No	No	0	7	6
41	R:R:P329	R:R:S328	30.4732	3.56	No	No	0	7	7
42	R:R:D305	R:R:Y177	13.1385	5.75	No	Yes	0	7	9
43	R:R:D305	R:R:R284	12.4136	13.1	No	No	0	7	5
44	R:R:E301	R:R:F5	17.3166	3.5	Yes	Yes	1	3	4
45	R:R:K291	R:R:Y287	11.8026	7.17	No	Yes	0	3	4
46	R:R:E301	R:R:Y287	16.3572	5.61	Yes	Yes	1	3	4
47	R:R:F323	R:R:M270	13.1318	7.46	No	No	0	9	9
48	R:R:I322	R:R:M270	12.1352	5.83	Yes	No	0	8	9
49	L:L:?1	R:R:M112	31.065	8.66	Yes	Yes	1	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N18	R:R:Y87	5.81	0	No	Yes	3	8	2	1
R:R:A20	R:R:Y87	5.34	0	No	Yes	6	8	2	1
R:R:M22	R:R:R310	8.69	0	No	Yes	3	9	2	1
L:L:?1	R:R:G23	3.49	1	Yes	No	0	8	0	1
R:R:F27	R:R:K76	3.72	0	Yes	No	8	8	2	1
R:R:F27	R:R:S80	15.85	0	Yes	Yes	8	8	2	1
L:L:?1	R:R:K76	11.52	1	Yes	No	0	8	0	1
R:R:F108	R:R:L79	8.53	1	Yes	No	6	6	2	1
R:R:L79	R:R:M112	4.24	1	No	Yes	6	8	1	1
L:L:?1	R:R:L79	11.3	1	Yes	No	0	6	0	1
R:R:P81	R:R:S80	3.56	0	No	Yes	8	8	2	1
L:L:?1	R:R:S80	10.22	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:V83	3.93	1	Yes	No	6	9	2	1
R:R:T181	R:R:V83	4.76	0	Yes	No	9	9	2	1
L:L:?1	R:R:V83	8.11	1	Yes	No	0	9	0	1
R:R:T181	R:R:Y87	19.97	0	Yes	Yes	9	8	2	1
L:L:?1	R:R:Y87	4.79	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:M112	3.73	1	Yes	Yes	6	8	2	1
R:R:F184	R:R:M112	6.22	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:M112	8.66	1	Yes	Yes	0	8	0	1
R:R:W182	R:R:Y177	25.08	1	Yes	Yes	9	9	1	2
R:R:F184	R:R:Y177	5.16	1	Yes	Yes	8	9	2	2
R:R:P179	R:R:W182	6.76	1	No	Yes	8	9	2	1
R:R:L306	R:R:P179	4.93	1	No	No	7	8	2	2
R:R:L306	R:R:W182	5.69	1	No	Yes	7	9	2	1
R:R:L309	R:R:W182	4.56	0	No	Yes	7	9	2	1
L:L:?1	R:R:W182	10.85	1	Yes	Yes	0	9	0	1
R:R:F184	R:R:L309	6.09	1	Yes	No	8	7	2	2
R:R:L312	R:R:V281	4.47	0	No	No	8	8	1	2
R:R:L306	R:R:R310	14.58	1	No	Yes	7	9	2	1
R:R:R307	R:R:R310	3.2	0	No	Yes	4	9	2	1
L:L:?1	R:R:R310	9.92	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:L312	3.77	1	Yes	No	0	8	0	1
L:L:?1	R:R:S313	10.22	1	Yes	No	0	9	0	1
R:R:L84	R:R:S80	3	0	No	Yes	7	8	2	1
R:R:I317	R:R:K76	2.91	0	Yes	No	9	8	2	1
L:L:?1	R:R:G116	2.33	1	Yes	No	0	8	0	1
R:R:G23	R:R:G24	2.11	0	No	No	8	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZVZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	295
Number of Links	332
Number of Hubs	42
Number of Links mediated by Hubs	163
Number of Communities	9
Number of Nodes involved in Communities	60
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	50
Number Of Links MetaPath	49
Number of Shortest Paths	135697
Length Of Smallest Path	3
Average Path Length	16.4167
Length of Longest Path	34
Minimum Path Strength	1.51
Average Path Strength	6.03401
Maximum Path Strength	16.51
Minimum Path Correlation	0.7
Average Path Correlation	0.927382
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	42.0381
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.764
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13258
Sequence	>8ZVZ_nogp_Chain_R S P F Y R C Q N T T S V E K G N S A V M G G V L F S T G L L G N L L A L G L L A R S G L G P L P S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N R S L R V L A P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H P F F Y R R H I T L R L G A L V A P V V S A F S L A F C A L P F M G F G K F V Q Y C P G T W C F I Q M V H E E G S L S V L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K D V K E K N R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P V F R I F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9E9S	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ1	2.68	2025-09-03	To be published
	9E9S (No Gprot)	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-		2.68	2025-09-03	To be published
	9EE5	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-2550289	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9EI5	A	Lipid	Prostanoid	DP₁	Homo sapiens	-	-	-	2.84	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9EKH	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-3030297	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9UWD	A	Lipid	Prostaglandin	DP₁	Homo sapiens	-	-	-	-	2025-04-09	doi.org/10.1073/pnas.2501902122
	8ZVZ	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZVZ (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	9AU0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.45	2025-08-27	To be published
	9AU0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.45	2025-08-27	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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