Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 5.8151210
2R:R:F5 9.3225414
3R:R:Y6 7.95667616
4R:R:R7 8.9775444
5R:R:E15 3.855443
6R:R:V60 3.205457
7R:R:Y62 4.7425407
8R:R:L68 5.19539
9R:R:D72 7.305439
10R:R:K76 5.79418
11R:R:F108 5.8975406
12R:R:M112 4.395418
13R:R:F114 7.125407
14R:R:F115 5.57568
15R:R:L117 4.755418
16R:R:W131 4.2825406
17R:R:Y140 8.425458
18R:R:F163 4.315617
19R:R:F174 6.0125406
20R:R:Y177 8.75833619
21R:R:T181 4.61619
22R:R:W182 9.0875409
23R:R:F184 7.1975418
24R:R:I185 6.546517
25R:R:Q186 5.532515
26R:R:H189 6.69667614
27R:R:Y199 6.35571716
28R:R:Y203 5.36667618
29R:R:M222 4.6425407
30R:R:H229 8.195426
31R:R:E260 4.37529
32R:R:M270 4.5875439
33R:R:F274 6.485439
34R:R:R284 11.83415
35R:R:Y286 5.015405
36R:R:Y287 8.408514
37R:R:E301 6.988513
38R:R:I317 5.01419
39R:R:D319 5.31539
40R:R:F323 4.65439
41R:R:I324 4.824509
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:Q9 R:R:Y6 12.73333.38NoYes126
2R:R:Y177 R:R:Y6 31.58589.93YesYes196
3R:R:W182 R:R:Y177 46.055418.33YesYes099
4L:L:?1 R:R:W182 46.634.36YesYes009
5L:L:?1 R:R:K76 10010.79YesYes108
6R:R:F184 R:R:Y177 19.32225.16YesYes189
7R:R:F184 R:R:M112 44.45334.98YesYes188
8L:L:?1 R:R:T181 22.85373.22YesYes109
9L:L:?1 R:R:L312 10.2634.54YesNo008
10R:R:F5 R:R:Y6 10.015512.38YesYes146
11R:R:Q186 R:R:Y6 10.77475.64YesYes156
12R:R:E15 R:R:P179 14.31873.14YesNo038
13R:R:K76 R:R:S316 98.05393.06YesNo088
14R:R:D72 R:R:S316 97.772911.78YesNo098
15R:R:D72 R:R:N34 16.21025.39YesNo099
16R:R:N34 R:R:P320 14.998113.03NoNo099
17R:R:P320 R:R:W321 12.54882.7NoNo098
18R:R:D319 R:R:D72 43.57677.98YesYes399
19R:R:D319 R:R:F323 22.69854.78YesYes399
20R:R:F323 R:R:V65 28.07112.62YesNo098
21R:R:I324 R:R:V65 20.08143.07YesNo098
22R:R:I324 R:R:L41 11.60937.14YesNo099
23R:R:L41 R:R:Y62 10.34692.34NoYes097
24R:R:D72 R:R:L68 49.41494.07YesYes399
25R:R:L68 R:R:M126 48.53845.65YesNo099
26R:R:L64 R:R:M126 58.84755.65NoNo089
27R:R:E129 R:R:L64 54.92185.3NoNo098
28R:R:E129 R:R:Y140 49.4828.98NoYes598
29R:R:F184 R:R:I185 55.215412.56YesYes187
30R:R:I185 R:R:Y203 30.91058.46YesYes178
31R:R:L117 R:R:Y203 16.77644.69YesYes188
32R:R:L117 R:R:S160 16.51647.51YesNo087
33R:R:S118 R:R:S160 15.29594.89NoNo077
34R:R:F114 R:R:S118 14.0676.61YesNo077
35R:R:F114 R:R:F115 10.330110.72YesYes078
36R:R:F108 R:R:M112 17.61523.73YesYes068
37R:R:F108 R:R:V82 11.65965.24YesNo066
38R:R:L104 R:R:V82 10.39722.98NoNo056
39R:R:I185 R:R:Y199 17.19584.84YesYes176
40R:R:D319 R:R:M270 18.7984.16YesYes399
41R:R:F274 R:R:M270 24.90883.73YesYes399
42R:R:F274 R:R:T214 21.385710.38YesNo098
43R:R:L124 R:R:T214 20.19464.42NoNo058
44R:R:L124 R:R:L128 17.78724.15NoNo057
45R:R:S133 R:R:Y140 44.80147.63NoYes098
46R:R:L134 R:R:S133 43.76554.5NoNo089
47R:R:L134 R:R:L225 31.0284.15NoNo089
48R:R:L225 R:R:L264 10.27974.15NoNo097
49R:R:L219 R:R:M222 12.49422.83NoYes057
50R:R:L219 R:R:V215 10.01132.98NoNo056
51R:R:C130 R:R:L134 12.1211.59NoNo098
52R:R:L128 R:R:W131 15.34622.28NoYes076
53R:R:M187 R:R:Y177 13.94967.18NoYes079
54R:R:D305 R:R:Y177 14.1976.9NoYes079
55R:R:H189 R:R:Q186 13.70213.71YesYes145
56R:R:A285 R:R:M187 11.58413.22NoNo077
57R:R:A285 R:R:S204 10.33013.42NoNo078
58R:R:E260 R:R:L225 21.02082.65YesNo099
59R:R:D305 R:R:R284 13.131713.1NoYes075
60R:R:P179 R:R:T181 17.70333.5NoYes089
61L:L:?1 R:R:M112 49.43594.63YesYes108
62R:R:V175 R:R:Y177 10.51465.05NoYes149
63R:R:F323 R:R:M126 11.71414.98YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K76 10.79 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S80 10.67 1 Yes No 0 8 0 1
L:L:?1 R:R:V83 8.14 1 Yes No 0 9 0 1
L:L:?1 R:R:Y87 5.76 1 Yes No 0 8 0 1
L:L:?1 R:R:M112 4.63 1 Yes Yes 0 8 0 1
L:L:?1 R:R:T181 3.22 1 Yes Yes 0 9 0 1
L:L:?1 R:R:W182 4.36 1 Yes Yes 0 9 0 1
L:L:?1 R:R:R310 3.98 1 Yes No 0 9 0 1
L:L:?1 R:R:L312 4.54 1 Yes No 0 8 0 1
L:L:?1 R:R:S313 9.02 1 Yes No 0 9 0 1
R:R:T181 R:R:V14 3.17 1 Yes No 9 4 1 2
R:R:A20 R:R:Y87 6.67 0 No No 6 8 2 1
R:R:M22 R:R:R310 11.17 0 No No 3 9 2 1
R:R:F27 R:R:S80 11.89 0 No No 8 8 2 1
R:R:G30 R:R:K76 3.49 1 No Yes 9 8 2 1
R:R:G30 R:R:I317 5.29 1 No Yes 9 9 2 2
R:R:K76 R:R:S316 3.06 1 Yes No 8 8 1 2
R:R:I317 R:R:K76 5.82 1 Yes Yes 9 8 2 1
R:R:P81 R:R:S80 3.56 0 No No 8 8 2 1
R:R:T181 R:R:V83 3.17 1 Yes No 9 9 1 1
R:R:A86 R:R:T181 3.36 0 No Yes 6 9 2 1
R:R:T181 R:R:Y87 11.24 1 Yes No 9 8 1 1
R:R:F108 R:R:M112 3.73 0 Yes Yes 6 8 2 1
R:R:F184 R:R:M112 4.98 1 Yes Yes 8 8 2 1
R:R:L309 R:R:M112 4.24 1 No Yes 7 8 2 1
R:R:W182 R:R:Y177 18.33 0 Yes Yes 9 9 1 2
R:R:F184 R:R:Y177 5.16 1 Yes Yes 8 9 2 2
R:R:P179 R:R:T181 3.5 0 No Yes 8 9 2 1
R:R:L306 R:R:W182 5.69 0 No Yes 7 9 2 1
R:R:L309 R:R:W182 7.97 1 No Yes 7 9 2 1
R:R:F184 R:R:L309 6.09 1 Yes No 8 7 2 2
R:R:L312 R:R:V281 5.96 0 No No 8 8 1 2
R:R:L306 R:R:R310 17.01 0 No No 7 9 2 1
L:L:?1 R:R:G23 2.8 1 Yes No 0 8 0 1
R:R:G23 R:R:G24 2.11 0 No No 8 4 1 2
L:L:?1 R:R:G116 1.87 1 Yes No 0 8 0 1
R:R:G116 R:R:S119 1.86 0 No No 8 8 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AU0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.06
Number of Linked Nodes 287
Number of Links 326
Number of Hubs 41
Number of Links mediated by Hubs 159
Number of Communities 7
Number of Nodes involved in Communities 67
Number of Links involved in Communities 90
Path Summary
Number Of Nodes in MetaPath 64
Number Of Links MetaPath 63
Number of Shortest Paths 48198
Length Of Smallest Path 3
Average Path Length 13.0081
Length of Longest Path 31
Minimum Path Strength 1.38
Average Path Strength 6.2495
Maximum Path Strength 18.71
Minimum Path Correlation 0.7
Average Path Correlation 0.921764
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 49.1065
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.9222
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • sleep   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • establishment of organelle localization   • regulated exocytosis   • cellular localization   • response to stimulus   • transport   • cell activation involved in immune response   • leukocyte degranulation   • myeloid leukocyte activation   • myeloid leukocyte mediated immunity   • vesicle-mediated transport   • leukocyte activation   • localization   • secretion by cell   • organelle localization   • leukocyte activation involved in immune response   • establishment of localization in cell   • mast cell activation   • leukocyte mediated immunity   • mast cell mediated immunity   • immune response   • secretion   • cell activation   • vacuolar localization   • export from cell   • mast cell degranulation   • establishment of localization   • myeloid cell activation involved in immune response   • immune effector process   • mast cell activation involved in immune response   • exocytosis   • immune system process   • lysosome localization   • cellular process   • developmental process   • multicellular organism development   • sex determination   • male sex determination   • reproductive process   • anatomical structure development   • developmental process involved in reproduction   • defense response   • response to stress   • inflammatory response   • cellular response to stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • cellular response to prostaglandin D stimulus   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to prostaglandin D   • response to chemical   • cellular response to lipid   • cellular response to ketone   • cellular response to hormone stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleoside metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • adenosine metabolic process   • nucleobase-containing small molecule metabolic process   • metabolic process   • small molecule metabolic process   • purine nucleoside metabolic process   • ribonucleoside metabolic process   • purine ribonucleoside metabolic process   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular response to prostaglandin E stimulus   • response to prostaglandin E   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • cell-cell signaling   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeA1A
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1A
Name6-AMINO HEXANOIC ACID
Synonyms
Identifier
FormulaC33 H40 N4 O6
Molecular Weight588.694
SMILES
PubChem5327090
Formal Charge0
Total Atoms83
Total Chiral Atoms4
Total Bonds86
Total Aromatic Bonds18

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ13258
Sequence
>9AU0_nogp_Chain_R
SPFYRCQNT TSVEKGNSA VMGGVLFST GLLGNLLAL GLLARSGLG 
WPSVFYMLV CGLTVTDLL GKCLLSPVV LAAYAQNRS LRVLAPALD 
NSLCQAFAF FMSFFGLSS TLQLLAMAL ECWLSLGHP FFYRRHITL 
RLGALVAPV VSAFSLAFC ALPFMGFGK FVQYCPGTW CFIQMVHEE 
GSLSVLGYS VLYSSLMAL LVLATVLCN LGAMRNLYA MHRRLQRHP 
QPLEELDHL LLLALMTVL FTMCSLPVI YRAYYGAFK DVKEKNRTS 
EEAEDLRAL RFLSVISIV DPWIFIIFR SPVFRIFFH K


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9UWDALipidProstaglandinDP1Homo sapiens----2025-04-09doi.org/10.1073/pnas.2501902122
8ZVZALipidProstaglandinDP1Homo sapiensBW245C-Gs/β1/γ22.352025-05-28doi.org/10.1073/pnas.2501902122
8ZVZ (No Gprot) ALipidProstaglandinDP1Homo sapiensBW245C-2.352025-05-28doi.org/10.1073/pnas.2501902122
8ZW0ALipidProstaglandinDP1Homo sapiensPGD2-Gs/β1/γ22.722025-05-28doi.org/10.1073/pnas.2501902122
8ZW0 (No Gprot) ALipidProstaglandinDP1Homo sapiensPGD2-2.722025-05-28doi.org/10.1073/pnas.2501902122
9AU0ALipidProstaglandinDP1Homo sapiensBW245C-Gs/β1/γ22.452025-08-27To be published
9AU0 (No Gprot) ALipidProstaglandinDP1Homo sapiensBW245C-2.452025-08-27To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9AU0_nogp.zip



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