psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E191	R:R:K2	2.7	No	No	0	1	5
2	R:R:P4	R:R:S3	3.56	No	No	0	6	6
3	R:R:P4	R:R:Q9	3.16	No	Yes	0	6	2
4	R:R:F5	R:R:V188	18.35	No	No	0	4	3
5	R:R:Q9	R:R:Y6	5.64	Yes	Yes	3	2	6
6	R:R:V175	R:R:Y6	5.05	No	Yes	3	4	6
7	R:R:Y177	R:R:Y6	11.91	Yes	Yes	3	9	6
8	R:R:Q186	R:R:Y6	6.76	Yes	Yes	3	5	6
9	R:R:R298	R:R:R7	6.4	No	No	0	1	4
10	R:R:R7	R:R:T299	6.47	No	No	0	4	1
11	R:R:C8	R:R:T11	5.07	No	No	1	9	4
12	R:R:C8	R:R:E15	6.08	No	No	1	9	3
13	R:R:C178	R:R:C8	7.28	Yes	No	1	4	9
14	R:R:N10	R:R:Q9	5.28	No	Yes	0	6	2
15	R:R:Q9	R:R:V175	2.87	Yes	No	3	2	4
16	R:R:N10	R:R:R94	4.82	No	No	0	6	2
17	R:R:E15	R:R:T11	12.7	No	No	1	3	4
18	R:R:T12	R:R:V95	6.35	No	Yes	0	5	2
19	R:R:K16	R:R:S13	4.59	No	No	0	1	1
20	R:R:N90	R:R:S13	4.47	No	No	0	5	1
21	R:R:N90	R:R:V14	4.43	No	No	0	5	4
22	R:R:C178	R:R:E15	3.04	Yes	No	1	4	3
23	R:R:G17	R:R:N18	3.39	No	No	0	3	3
24	R:R:A20	R:R:Y87	5.34	No	No	0	6	8
25	R:R:L26	R:R:M22	7.07	No	No	0	8	3
26	R:R:F27	R:R:L31	3.65	Yes	No	0	8	6
27	R:R:F27	R:R:K76	3.72	Yes	Yes	8	8	8
28	R:R:F27	R:R:S80	10.57	Yes	No	8	8	8
29	R:R:F27	R:R:L84	4.87	Yes	No	0	8	7
30	R:R:G30	R:R:I317	5.29	No	No	0	9	9
31	R:R:L31	R:R:L35	4.15	No	No	0	6	5
32	R:R:L32	R:R:L36	5.54	No	No	0	4	5
33	R:R:G33	R:R:W321	4.22	No	No	0	9	8
34	R:R:K76	R:R:N34	4.2	Yes	No	0	8	9
35	R:R:N34	R:R:P320	14.66	No	No	0	9	9
36	R:R:I324	R:R:L36	2.85	Yes	No	0	9	5
37	R:R:A37	R:R:F323	2.77	No	Yes	0	9	9
38	R:R:L38	R:R:T69	4.42	No	No	0	7	8
39	R:R:I324	R:R:L40	2.85	Yes	No	0	9	8
40	R:R:L40	R:R:R327	4.86	No	No	0	8	9
41	R:R:F323	R:R:L41	6.09	Yes	No	0	9	9
42	R:R:L46	R:R:P58	4.93	No	No	0	4	6
43	R:R:L46	R:R:M63	2.83	No	No	0	4	6
44	R:R:P53	R:R:R52	5.76	No	No	0	4	6
45	R:R:L54	R:R:R52	3.64	No	No	0	2	6
46	R:R:R52	R:R:R55	8.53	No	No	0	6	4
47	R:R:L54	R:R:P56	8.21	No	No	0	2	3
48	R:R:L57	R:R:P58	6.57	No	No	0	7	6
49	R:R:H263	R:R:S59	4.18	Yes	No	0	8	7
50	R:R:L64	R:R:V60	2.98	No	Yes	0	8	7
51	R:R:E129	R:R:V60	5.7	No	Yes	5	9	7
52	R:R:V60	R:R:Y140	3.79	Yes	Yes	5	7	8
53	R:R:I144	R:R:V60	4.61	Yes	Yes	5	5	7
54	R:R:F61	R:R:V65	3.93	No	No	0	9	8
55	R:R:F61	R:R:H263	14.71	No	Yes	0	9	8
56	R:R:F61	R:R:L266	8.53	No	No	0	9	8
57	R:R:H263	R:R:Y62	7.62	Yes	No	0	8	7
58	R:R:G149	R:R:M63	5.24	No	No	0	7	6
59	R:R:L64	R:R:M126	7.07	No	No	0	8	9
60	R:R:L64	R:R:V152	4.47	No	No	0	8	5
61	R:R:F323	R:R:V65	3.93	Yes	No	0	9	8
62	R:R:D72	R:R:L68	9.5	No	No	0	9	9
63	R:R:L68	R:R:S119	3	No	No	0	9	8
64	R:R:L68	R:R:Q122	7.99	No	Yes	0	9	7
65	R:R:Q122	R:R:T71	7.09	Yes	No	0	7	9
66	R:R:D319	R:R:D72	2.66	Yes	No	0	9	9
67	R:R:L74	R:R:L78	6.92	No	No	2	4	6
68	R:R:F115	R:R:G75	9.03	Yes	No	0	8	9
69	R:R:K76	R:R:S80	6.12	Yes	No	8	8	8
70	R:R:K76	R:R:S316	7.65	Yes	No	0	8	8
71	R:R:F108	R:R:L79	7.31	Yes	No	1	6	6
72	R:R:L79	R:R:M112	7.07	No	No	1	6	8
73	R:R:L93	R:R:V82	4.47	Yes	No	1	6	6
74	R:R:L104	R:R:V82	4.47	Yes	No	1	5	6
75	R:R:F108	R:R:V82	3.93	Yes	No	1	6	6
76	R:R:V83	R:R:Y87	3.79	No	No	1	9	8
77	R:R:T181	R:R:V83	3.17	Yes	No	1	9	9
78	R:R:T181	R:R:Y87	9.99	Yes	No	1	9	8
79	R:R:Q89	R:R:R91	11.68	No	No	1	5	3
80	R:R:L96	R:R:Q89	6.65	Yes	No	1	4	5
81	R:R:R91	R:R:V95	7.85	No	Yes	0	3	2
82	R:R:L96	R:R:R91	4.86	Yes	No	1	4	3
83	R:R:R94	R:R:S92	3.95	No	No	7	2	5
84	R:R:S92	R:R:V95	4.85	No	Yes	0	5	2
85	R:R:Q176	R:R:S92	5.78	Yes	No	7	5	5
86	R:R:L104	R:R:L93	4.15	Yes	Yes	1	5	6
87	R:R:F108	R:R:L93	4.87	Yes	Yes	1	6	6
88	R:R:Q176	R:R:R94	10.51	Yes	No	7	5	2
89	R:R:D101	R:R:V95	2.92	No	Yes	0	4	2
90	R:R:L104	R:R:L96	4.15	Yes	Yes	1	5	4
91	R:R:A97	R:R:L104	3.15	No	Yes	0	1	5
92	R:R:L100	R:R:S103	4.5	No	No	0	4	3
93	R:R:D101	R:R:N102	9.42	No	No	0	4	1
94	R:R:C105	R:R:C183	7.28	No	No	0	9	9
95	R:R:A107	R:R:F111	2.77	No	No	0	5	5
96	R:R:F108	R:R:M112	6.22	Yes	No	1	6	8
97	R:R:A109	R:R:F174	9.71	No	No	0	8	6
98	R:R:F110	R:R:F111	5.36	Yes	No	0	7	5
99	R:R:F110	R:R:L161	3.65	Yes	No	0	7	3
100	R:R:C164	R:R:F110	4.19	No	Yes	0	8	7
101	R:R:F110	R:R:F168	16.08	Yes	No	0	7	4
102	R:R:C164	R:R:S113	5.16	No	No	0	8	7
103	R:R:F114	R:R:F115	11.79	Yes	Yes	2	7	8
104	R:R:F114	R:R:S118	7.93	Yes	No	2	7	7
105	R:R:F114	R:R:S157	6.61	Yes	No	0	7	6
106	R:R:F114	R:R:S160	5.28	Yes	No	2	7	7
107	R:R:L117	R:R:L121	5.54	Yes	Yes	0	8	5
108	R:R:L117	R:R:S160	9.01	Yes	No	2	8	7
109	R:R:F163	R:R:L117	4.87	Yes	Yes	2	7	8
110	R:R:L117	R:R:L206	4.15	Yes	Yes	2	8	5
111	R:R:S118	R:R:V156	3.23	No	No	0	7	6
112	R:R:S118	R:R:S160	4.89	No	No	2	7	7
113	R:R:L210	R:R:T120	5.9	Yes	No	0	6	7
114	R:R:L121	R:R:V156	5.96	Yes	No	0	5	6
115	R:R:F159	R:R:L121	3.65	No	Yes	0	4	5
116	R:R:L121	R:R:L210	2.77	Yes	Yes	0	5	6
117	R:R:Q122	R:R:V156	2.87	Yes	No	0	7	6
118	R:R:L123	R:R:M126	2.83	Yes	No	4	8	9
119	R:R:L123	R:R:T214	2.95	Yes	No	4	8	8
120	R:R:L123	R:R:M270	2.83	Yes	No	4	8	9
121	R:R:L123	R:R:T271	7.37	Yes	No	4	8	8
122	R:R:F274	R:R:L123	4.87	No	Yes	4	9	8
123	R:R:L124	R:R:L128	5.54	No	No	0	5	7
124	R:R:L124	R:R:T214	5.9	No	No	0	5	8
125	R:R:M126	R:R:M270	4.33	No	No	4	9	9
126	R:R:A127	R:R:L267	3.15	No	No	0	9	9
127	R:R:C217	R:R:L128	3.17	No	No	0	7	7
128	R:R:E129	R:R:Y140	7.86	No	Yes	5	9	8
129	R:R:C130	R:R:L264	3.17	No	Yes	0	9	7
130	R:R:C130	R:R:L267	3.17	No	No	0	9	9
131	R:R:L132	R:R:W131	6.83	Yes	Yes	5	5	6
132	R:R:H136	R:R:W131	6.35	No	Yes	5	4	6
133	R:R:G220	R:R:W131	2.81	No	Yes	0	5	6
134	R:R:H136	R:R:L132	5.14	No	Yes	5	4	5
135	R:R:F139	R:R:L132	3.65	No	Yes	0	5	5
136	R:R:I144	R:R:L132	2.85	Yes	Yes	5	5	5
137	R:R:E260	R:R:S133	8.62	No	No	0	9	9
138	R:R:L134	R:R:L225	2.77	No	No	0	8	9
139	R:R:E260	R:R:L134	15.9	No	No	0	9	8
140	R:R:G135	R:R:H136	3.18	No	No	0	7	4
141	R:R:F139	R:R:H143	27.15	No	No	0	5	5
142	R:R:I144	R:R:Y140	19.34	Yes	Yes	5	5	8
143	R:R:H143	R:R:R142	12.41	No	No	0	5	5
144	R:R:I144	R:R:L148	4.28	Yes	No	0	5	5
145	R:R:R147	R:R:T145	7.76	No	No	0	4	6
146	R:R:L148	R:R:V152	4.47	No	No	0	5	5
147	R:R:L151	R:R:V155	2.98	No	No	0	3	3
148	R:R:F163	R:R:Y199	5.16	Yes	Yes	0	7	6
149	R:R:F163	R:R:L202	4.87	Yes	No	0	7	5
150	R:R:F163	R:R:Y203	4.13	Yes	No	0	7	8
151	R:R:F163	R:R:L206	4.87	Yes	Yes	2	7	5
152	R:R:C164	R:R:Y199	2.69	No	Yes	0	8	6
153	R:R:L166	R:R:Y199	7.03	No	Yes	0	7	6
154	R:R:F174	R:R:P167	10.11	No	No	0	6	9
155	R:R:P167	R:R:Y199	11.13	No	Yes	0	9	6
156	R:R:G170	R:R:K173	3.49	No	No	0	6	2
157	R:R:G172	R:R:Y199	4.35	No	Yes	0	8	6
158	R:R:F174	R:R:I185	7.54	No	Yes	0	6	7
159	R:R:Q186	R:R:V175	10.03	Yes	No	3	5	4
160	R:R:G180	R:R:Q176	4.93	No	Yes	0	6	5
161	R:R:C183	R:R:Q176	6.1	No	Yes	0	9	5
162	R:R:F184	R:R:Y177	3.09	Yes	Yes	3	8	9
163	R:R:M187	R:R:Y177	4.79	No	Yes	0	7	9
164	R:R:D305	R:R:Y177	9.2	No	Yes	3	7	9
165	R:R:L309	R:R:Y177	4.69	No	Yes	3	7	9
166	R:R:C178	R:R:P179	5.65	Yes	Yes	1	4	8
167	R:R:C178	R:R:E302	10.64	Yes	No	1	4	3
168	R:R:P179	R:R:T181	3.5	Yes	Yes	1	8	9
169	R:R:P179	R:R:W182	2.7	Yes	Yes	1	8	9
170	R:R:E302	R:R:P179	4.72	No	Yes	1	3	8
171	R:R:L306	R:R:P179	6.57	No	Yes	1	7	8
172	R:R:T181	R:R:W182	10.92	Yes	Yes	1	9	9
173	R:R:L306	R:R:W182	4.56	No	Yes	1	7	9
174	R:R:S313	R:R:W182	7.41	No	Yes	0	9	9
175	R:R:F184	R:R:I185	11.3	Yes	Yes	0	8	7
176	R:R:F184	R:R:L309	3.65	Yes	No	3	8	7
177	R:R:I185	R:R:Y199	6.04	Yes	Yes	0	7	6
178	R:R:I185	R:R:Y203	4.84	Yes	No	0	7	8
179	R:R:H189	R:R:Q186	11.13	Yes	Yes	3	4	5
180	R:R:Q186	R:R:V196	2.87	Yes	No	3	5	5
181	R:R:V188	R:R:V293	8.02	No	No	6	3	1
182	R:R:E191	R:R:H189	16	No	Yes	0	1	4
183	R:R:H189	R:R:V196	5.54	Yes	No	3	4	5
184	R:R:E190	R:R:V293	5.7	No	No	0	1	1
185	R:R:E190	R:R:K294	5.4	No	No	0	1	1
186	R:R:S193	R:R:V196	6.46	No	No	0	3	5
187	R:R:A289	R:R:L197	6.3	No	No	0	7	4
188	R:R:F290	R:R:V201	6.55	No	No	0	3	4
189	R:R:M207	R:R:Y203	5.99	No	No	0	7	8
190	R:R:A285	R:R:S204	3.42	No	No	0	7	8
191	R:R:S204	R:R:Y286	7.63	No	No	0	8	5
192	R:R:L206	R:R:L209	4.15	Yes	No	2	5	3
193	R:R:L206	R:R:L210	5.54	Yes	Yes	2	5	6
194	R:R:M207	R:R:S278	6.13	No	No	11	7	9
195	R:R:I282	R:R:M207	8.75	Yes	No	11	8	7
196	R:R:L209	R:R:L210	2.77	No	Yes	2	3	6
197	R:R:T275	R:R:V211	4.76	No	No	0	5	8
198	R:R:L212	R:R:L216	2.77	No	No	0	3	4
199	R:R:T214	R:R:T271	4.71	No	No	4	8	8
200	R:R:L219	R:R:V215	2.98	No	No	0	5	6
201	R:R:M222	R:R:N218	9.82	No	No	9	7	9
202	R:R:L264	R:R:N218	2.75	Yes	No	9	7	9
203	R:R:A268	R:R:N218	4.69	No	No	0	6	9
204	R:R:L264	R:R:M222	7.07	Yes	No	9	7	7
205	R:R:L225	R:R:L261	2.77	No	No	0	9	5
206	R:R:L225	R:R:L264	4.15	No	Yes	0	9	7
207	R:R:H336	R:R:L258	9	No	No	0	4	6
208	R:R:E259	R:R:H263	9.85	No	Yes	0	6	8
209	R:R:D262	R:R:L261	2.71	No	No	0	9	5
210	R:R:F339	R:R:L261	6.09	No	No	0	5	5
211	R:R:D262	R:R:H336	12.61	No	No	0	9	4
212	R:R:F326	R:R:L265	6.09	Yes	No	0	5	6
213	R:R:F335	R:R:L265	13.4	No	No	0	4	6
214	R:R:L266	R:R:M270	4.24	No	No	0	8	9
215	R:R:F326	R:R:L266	10.96	Yes	No	0	5	8
216	R:R:I322	R:R:L269	4.28	No	No	0	8	5
217	R:R:F326	R:R:L269	6.09	Yes	No	0	5	5
218	R:R:M276	R:R:V272	3.04	No	No	0	5	5
219	R:R:C277	R:R:L273	3.17	No	No	0	9	8
220	R:R:L273	R:R:V318	2.98	No	No	0	8	8
221	R:R:I322	R:R:L273	2.85	No	No	0	8	8
222	R:R:F274	R:R:I315	7.54	No	No	4	9	9
223	R:R:D319	R:R:F274	10.75	Yes	No	4	9	9
224	R:R:L279	R:R:T275	4.42	No	No	0	7	5
225	R:R:C277	R:R:I315	4.91	No	No	0	9	9
226	R:R:I282	R:R:S278	3.1	Yes	No	11	8	9
227	R:R:L312	R:R:V281	7.45	No	No	0	8	8
228	R:R:I282	R:R:Y286	8.46	Yes	No	0	8	5
229	R:R:Y283	R:R:Y287	7.94	No	No	0	6	4
230	R:R:R284	R:R:Y287	3.09	Yes	No	0	5	4
231	R:R:E301	R:R:R284	10.47	No	Yes	0	3	5
232	R:R:E304	R:R:R284	4.65	No	Yes	0	1	5
233	R:R:A308	R:R:R284	2.77	No	Yes	0	7	5
234	R:R:K291	R:R:Y287	5.97	No	No	0	3	4
235	R:R:A289	R:R:F290	2.77	No	No	0	7	3
236	R:R:D292	R:R:K294	6.91	No	No	10	2	1
237	R:R:D292	R:R:K296	5.53	No	No	10	2	1
238	R:R:K294	R:R:K296	2.87	No	No	10	1	1
239	R:R:N297	R:R:S300	7.45	No	No	0	3	1
240	R:R:D305	R:R:L309	4.07	No	No	3	7	7
241	R:R:L306	R:R:R310	15.79	No	No	0	7	9
242	R:R:F311	R:R:R307	8.55	No	No	0	6	4
243	R:R:D319	R:R:I315	4.2	Yes	No	4	9	9
244	R:R:I317	R:R:S316	3.1	No	No	0	9	8
245	R:R:D319	R:R:P320	3.22	Yes	No	0	9	9
246	R:R:I324	R:R:W321	3.52	Yes	No	0	9	8
247	R:R:F323	R:R:R327	6.41	Yes	No	0	9	9
248	R:R:I324	R:R:I325	2.94	Yes	No	0	9	8
249	R:R:F331	R:R:I325	7.54	Yes	No	0	7	8
250	R:R:F326	R:R:F331	9.65	Yes	Yes	0	5	7
251	R:R:R327	R:R:R332	4.26	No	No	0	9	6
252	R:R:F331	R:R:F335	10.72	Yes	No	0	7	4
253	R:R:H336	R:R:R332	5.64	No	No	0	4	6
254	R:R:I338	R:R:K337	2.91	No	No	0	4	3
255	R:R:N102	R:R:Q106	2.64	No	No	0	1	4
256	R:R:F108	R:R:V83	2.62	Yes	No	1	6	9
257	R:R:D305	R:R:E301	2.6	No	No	0	7	3
258	R:R:F334	R:R:K337	2.48	No	No	0	4	3
259	R:R:F115	R:R:L74	2.44	Yes	No	2	8	4
260	R:R:F115	R:R:L78	2.44	Yes	No	2	8	6
261	R:R:F184	R:R:L312	2.44	Yes	No	0	8	8
262	R:R:L146	R:R:R147	2.43	No	No	0	4	4
263	R:R:E301	R:R:F5	2.33	No	No	0	3	4
264	R:R:N224	R:R:W131	2.26	No	Yes	0	7	6
265	R:R:G23	R:R:G24	2.11	No	No	0	8	4
266	R:R:G135	R:R:P137	2.03	No	No	0	7	9
267	R:R:A42	R:R:G47	1.95	No	No	0	4	5
268	R:R:A97	R:R:P98	1.87	No	No	0	1	5
269	R:R:A153	R:R:P154	1.87	No	No	0	7	4
270	R:R:A308	R:R:P280	1.87	No	No	0	7	9
271	R:R:G149	R:R:V60	1.84	No	Yes	0	7	7
272	R:R:G288	R:R:V188	1.84	No	No	6	7	3
273	R:R:G288	R:R:V293	1.84	No	No	6	7	1
274	R:R:G30	R:R:T29	1.82	No	No	0	9	6
275	R:R:A42	R:R:C49	1.81	No	No	0	4	5
276	R:R:A221	R:R:C130	1.81	No	No	0	9	9
277	R:R:P81	R:R:S80	1.78	No	No	0	8	8
278	R:R:P329	R:R:S328	1.78	No	No	0	7	7
279	R:R:P329	R:R:V330	1.77	No	No	0	7	7
280	R:R:G24	R:R:L84	1.71	No	No	0	4	7
281	R:R:C66	R:R:V70	1.71	No	No	0	6	5
282	R:R:G192	R:R:L197	1.71	No	No	0	1	4
283	R:R:A285	R:R:S200	1.71	No	No	0	7	7
284	R:R:C277	R:R:V314	1.71	No	No	0	9	4
285	R:R:A125	R:R:V152	1.7	No	No	0	7	5
286	R:R:I333	R:R:P329	1.69	No	No	0	5	7
287	R:R:L279	R:R:P280	1.64	No	No	0	7	9
288	R:R:S193	R:R:S195	1.63	No	No	0	3	1
289	R:R:A208	R:R:I282	1.62	No	Yes	0	6	8
290	R:R:A150	R:R:M63	1.61	No	No	0	5	6
291	R:R:A165	R:R:M169	1.61	No	No	0	5	3
292	R:R:V21	R:R:V25	1.6	No	No	0	3	4
293	R:R:V211	R:R:V215	1.6	No	No	0	8	6
294	R:R:T29	R:R:V25	1.59	No	No	0	6	4
295	R:R:T69	R:R:V65	1.59	No	No	0	8	8
296	R:R:A85	R:R:L96	1.58	No	Yes	0	6	4
297	R:R:A86	R:R:L93	1.58	No	Yes	0	6	6
298	R:R:A97	R:R:L100	1.58	No	No	0	1	4
299	R:R:A99	R:R:L100	1.58	No	No	0	5	4
300	R:R:A213	R:R:L124	1.58	No	No	0	6	5
301	R:R:M22	R:R:S19	1.53	No	No	0	3	6
302	R:R:A153	R:R:Q122	1.52	No	Yes	0	7	7
303	R:R:G45	R:R:R55	1.5	No	No	0	6	4
304	R:R:G47	R:R:R55	1.5	No	No	0	5	4
305	R:R:L209	R:R:S205	1.5	No	No	0	3	4
306	R:R:G220	R:R:R223	1.5	No	No	0	5	4
307	R:R:N297	R:R:T299	1.46	No	No	0	3	1
308	R:R:I317	R:R:L26	1.43	No	No	0	9	8
309	R:R:I340	R:R:L258	1.43	No	No	0	6	6
310	R:R:L166	R:R:M169	1.41	No	No	0	7	3
311	R:R:C178	R:R:R7	1.39	Yes	No	0	4	4
312	R:R:L31	R:R:L73	1.38	No	No	0	6	8
313	R:R:L38	R:R:L73	1.38	No	No	0	7	8
314	R:R:L146	R:R:L57	1.38	No	No	0	4	7
315	R:R:R51	R:R:S50	1.32	No	No	0	5	5
316	R:R:F331	R:R:S328	1.32	Yes	No	0	7	7
317	R:R:H189	R:R:L197	1.29	Yes	No	0	4	4
318	R:R:F171	R:R:L166	1.22	No	No	0	4	7
319	R:R:E304	R:R:R307	1.16	No	No	0	1	4
320	R:R:L46	R:R:W48	1.14	No	No	0	4	5
321	R:R:F138	R:R:R142	1.07	No	No	0	7	5
322	R:R:R141	R:R:Y140	1.03	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y6	7.34	4	3	6
2	R:R:Q9	4.2375	4	3	2
3	R:R:F27	5.7025	4	8	8
4	R:R:V60	3.784	5	5	7
5	R:R:K76	5.4225	4	8	8
6	R:R:L93	3.7675	4	1	6
7	R:R:V95	5.4925	4	0	2
8	R:R:L96	4.31	4	1	4
9	R:R:L104	3.98	4	1	5
10	R:R:F108	4.99	5	1	6
11	R:R:F110	7.32	4	0	7
12	R:R:F114	7.9025	4	2	7
13	R:R:F115	6.425	4	2	8
14	R:R:L117	5.8925	4	2	8
15	R:R:L121	4.48	4	0	5
16	R:R:Q122	4.8675	4	0	7
17	R:R:L123	4.17	5	4	8
18	R:R:W131	4.5625	4	5	6
19	R:R:L132	4.6175	4	5	5
20	R:R:Y140	8.005	4	5	8
21	R:R:I144	7.77	4	5	5
22	R:R:F163	4.78	5	2	7
23	R:R:Q176	6.83	4	7	5
24	R:R:Y177	6.736	5	3	9
25	R:R:C178	5.6	5	1	4
26	R:R:P179	4.628	5	1	8
27	R:R:T181	6.895	4	1	9
28	R:R:W182	6.3975	4	1	9
29	R:R:F184	5.12	4	3	8
30	R:R:I185	7.43	4	0	7
31	R:R:Q186	7.6975	4	3	5
32	R:R:H189	8.49	4	3	4
33	R:R:Y199	6.06667	6	0	6
34	R:R:L206	4.6775	4	2	5
35	R:R:L210	4.245	4	2	6
36	R:R:H263	9.09	4	0	8
37	R:R:L264	4.285	4	9	7
38	R:R:I282	5.4825	4	11	8
39	R:R:R284	5.245	4	0	5
40	R:R:D319	5.2075	4	4	9
41	R:R:F323	4.8	4	0	9
42	R:R:I324	3.04	4	0	9
43	R:R:F326	8.1975	4	0	5
44	R:R:F331	7.3075	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q186	R:R:Y6	10.9824	6.76	Yes	Yes	3	5	6
2	R:R:Q9	R:R:Y6	60.7427	5.64	Yes	Yes	3	2	6
3	R:R:Y177	R:R:Y6	68.9595	11.91	Yes	Yes	3	9	6
4	R:R:D305	R:R:Y177	21.4768	9.2	No	Yes	3	7	9
5	R:R:D305	R:R:E301	36.7172	2.6	No	No	0	7	3
6	R:R:E301	R:R:F5	13.0301	2.33	No	No	0	3	4
7	R:R:F5	R:R:V188	11.4162	18.35	No	No	0	4	3
8	R:R:N10	R:R:Q9	60.9336	5.28	No	Yes	0	6	2
9	R:R:N10	R:R:R94	60.2785	4.82	No	No	0	6	2
10	R:R:R94	R:R:S92	56.3393	3.95	No	No	7	2	5
11	R:R:S92	R:R:V95	56.2569	4.85	No	Yes	0	5	2
12	R:R:R91	R:R:V95	52.7863	7.85	No	Yes	0	3	2
13	R:R:L96	R:R:R91	51.2353	4.86	Yes	No	1	4	3
14	R:R:L104	R:R:L96	49.9317	4.15	Yes	Yes	1	5	4
15	R:R:L104	R:R:V82	22.3271	4.47	Yes	No	1	5	6
16	R:R:F108	R:R:V82	21.518	3.93	Yes	No	1	6	6
17	R:R:F108	R:R:V83	38.023	2.62	Yes	No	1	6	9
18	R:R:T181	R:R:V83	32.8474	3.17	Yes	No	1	9	9
19	R:R:P179	R:R:T181	24.4138	3.5	Yes	Yes	1	8	9
20	R:R:C178	R:R:P179	17.5896	5.65	Yes	Yes	1	4	8
21	R:R:L104	R:R:L93	23.1904	4.15	Yes	Yes	1	5	6
22	R:R:F108	R:R:L93	21.57	4.87	Yes	Yes	1	6	6
23	R:R:F184	R:R:Y177	81.5384	3.09	Yes	Yes	3	8	9
24	R:R:F184	R:R:I185	100	11.3	Yes	Yes	0	8	7
25	R:R:I185	R:R:Y199	51.4761	6.04	Yes	Yes	0	7	6
26	R:R:F163	R:R:Y199	51.988	5.16	Yes	Yes	0	7	6
27	R:R:F163	R:R:L117	96.8938	4.87	Yes	Yes	2	7	8
28	R:R:L117	R:R:L121	91.1737	5.54	Yes	Yes	0	8	5
29	R:R:L121	R:R:V156	91.6835	5.96	Yes	No	0	5	6
30	R:R:Q122	R:R:V156	93.3537	2.87	Yes	No	0	7	6
31	R:R:L68	R:R:Q122	91.4362	7.99	No	Yes	0	9	7
32	R:R:D72	R:R:L68	90.4514	9.5	No	No	0	9	9
33	R:R:D319	R:R:D72	89.9525	2.66	Yes	No	0	9	9
34	R:R:D319	R:R:P320	19.2447	3.22	Yes	No	0	9	9
35	R:R:N34	R:R:P320	18.325	14.66	No	No	0	9	9
36	R:R:K76	R:R:N34	17.5116	4.2	Yes	No	0	8	9
37	R:R:I185	R:R:Y203	49.8536	4.84	Yes	No	0	7	8
38	R:R:F163	R:R:Y203	49.756	4.13	Yes	No	0	7	8
39	R:R:D319	R:R:F274	69.5928	10.75	Yes	No	4	9	9
40	R:R:F274	R:R:L123	69.6753	4.87	No	Yes	4	9	8
41	R:R:L123	R:R:M270	38.6716	2.83	Yes	No	4	8	9
42	R:R:L266	R:R:M270	41.6173	4.24	No	No	0	8	9
43	R:R:F326	R:R:L266	15.0409	10.96	Yes	No	0	5	8
44	R:R:F326	R:R:F331	12.2318	9.65	Yes	Yes	0	5	7
45	R:R:F323	R:R:V65	22.6351	3.93	Yes	No	0	9	8
46	R:R:F61	R:R:V65	23.8021	3.93	No	No	0	9	8
47	R:R:F61	R:R:L266	27.7239	8.53	No	No	0	9	8
48	R:R:F323	R:R:R327	20.0299	6.41	Yes	No	0	9	9
49	R:R:L123	R:R:M126	26.5526	2.83	Yes	No	4	8	9
50	R:R:L64	R:R:M126	29.3898	7.07	No	No	0	8	9
51	R:R:L64	R:R:V60	25.6914	2.98	No	Yes	0	8	7
52	R:R:I144	R:R:V60	12.7503	4.61	Yes	Yes	5	5	7
53	R:R:L225	R:R:L261	12.1277	2.77	No	No	0	9	5
54	R:R:D262	R:R:L261	14.0886	2.71	No	No	0	9	5
55	R:R:D262	R:R:H336	14.9975	12.61	No	No	0	9	4
56	R:R:H336	R:R:R332	17.8933	5.64	No	No	0	4	6
57	R:R:R327	R:R:R332	18.7935	4.26	No	No	0	9	6
58	R:R:I144	R:R:L132	11.9715	2.85	Yes	Yes	5	5	5
59	R:R:E301	R:R:R284	22.6199	10.47	No	Yes	0	3	5
60	R:R:A308	R:R:R284	11.4162	2.77	No	Yes	0	7	5
61	R:R:D305	R:R:L309	16.6504	4.07	No	No	3	7	7
62	R:R:F184	R:R:L309	17.2903	3.65	Yes	No	3	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9UWD

PDB Summary
PDB	9UWD
Class	A
SubFamily	Lipid
Type	Prostaglandin
SubType	DP1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	-
Date	2025-04-09
D.O.I.	doi.org/10.1073/pnas.2501902122

Net Summary
I_min	2.66
Number of Linked Nodes	293
Number of Links	322
Number of Hubs	44
Number of Links mediated by Hubs	156
Number of Communities	11
Number of Nodes involved in Communities	74
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	68886
Length Of Smallest Path	3
Average Path Length	21.3935
Length of Longest Path	48
Minimum Path Strength	1.315
Average Path Strength	5.67077
Maximum Path Strength	19.78
Minimum Path Correlation	0.7
Average Path Correlation	0.930791
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5
Average % Of Corr. Nodes	42.0998
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.6802
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • sleep • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • establishment of organelle localization • regulated exocytosis • cellular localization • response to stimulus • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • cellular process • developmental process • multicellular organism development • sex determination • male sex determination • reproductive process • anatomical structure development • developmental process involved in reproduction • defense response • response to stress • inflammatory response • cellular response to stimulus • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • response to chemical • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • regulation of biological process • regulation of cellular process • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • carbohydrate derivative metabolic process • primary metabolic process • nucleoside metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • adenosine metabolic process • nucleobase-containing small molecule metabolic process • metabolic process • small molecule metabolic process • purine nucleoside metabolic process • ribonucleoside metabolic process • purine ribonucleoside metabolic process • cellular anatomical structure • membrane • cell periphery • plasma membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13258
Sequence	>9UWD_Chain_R M K S P F Y R C Q N T T S V E K G N S A V M G G V L F S T G L L G N L L A L G L L A R S G L G W C S R R P L R P L P S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N R S L R V L A P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H P F F Y R R H I T L R L G A L V A P V V S A F S L A F C A L P F M G F G K F V Q Y C P G T W C F I Q M V H E E G S L S V L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K D V K E K N R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P V F R I F F H K I F I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZVZ	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZVZ (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	9AU0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.45	2025-08-27	To be published
	9AU0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.45	2025-08-27	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9UWD.zip

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