psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F5	R:R:Y6	16.5	Yes	Yes	1	4	6
2	R:R:F5	R:R:V188	7.87	Yes	No	1	4	3
3	R:R:E295	R:R:F5	3.5	No	Yes	1	1	4
4	R:R:E301	R:R:F5	3.5	Yes	Yes	1	3	4
5	R:R:Q9	R:R:Y6	4.51	No	Yes	0	2	6
6	R:R:V175	R:R:Y6	8.83	No	Yes	1	4	6
7	R:R:Y177	R:R:Y6	3.97	Yes	Yes	1	9	6
8	R:R:Q186	R:R:Y6	5.64	Yes	Yes	1	5	6
9	R:R:V188	R:R:Y6	8.83	No	Yes	1	3	6
10	R:R:C8	R:R:R7	4.18	No	Yes	0	9	4
11	R:R:C178	R:R:R7	5.57	No	Yes	1	4	4
12	R:R:E302	R:R:R7	4.65	No	Yes	1	3	4
13	R:R:C8	R:R:T11	8.45	No	No	0	9	4
14	R:R:N10	R:R:Q9	7.92	No	No	0	6	2
15	R:R:S92	R:R:T12	3.2	No	No	4	5	5
16	R:R:T12	R:R:V95	11.11	No	No	4	5	2
17	R:R:N90	R:R:V14	4.43	No	No	0	5	4
18	R:R:E15	R:R:K16	4.05	No	No	1	3	1
19	R:R:E15	R:R:G17	4.91	No	No	1	3	3
20	R:R:G17	R:R:K16	3.49	No	No	1	3	1
21	R:R:N18	R:R:Y87	9.3	No	Yes	1	3	8
22	R:R:N18	R:R:P179	3.26	No	Yes	1	3	8
23	R:R:A20	R:R:Y87	9.34	No	Yes	0	6	8
24	R:R:M22	R:R:R310	14.89	No	No	0	3	9
25	R:R:G24	R:R:L84	3.42	No	No	0	4	7
26	R:R:F27	R:R:L31	4.87	No	No	0	8	6
27	R:R:F27	R:R:S80	11.89	No	Yes	1	8	8
28	R:R:F27	R:R:P81	5.78	No	No	1	8	8
29	R:R:I317	R:R:T29	4.56	Yes	No	0	9	6
30	R:R:G30	R:R:I317	7.05	No	Yes	0	9	9
31	R:R:L31	R:R:L35	5.54	No	No	0	6	5
32	R:R:G33	R:R:W321	4.22	No	No	0	9	8
33	R:R:N34	R:R:T69	5.85	Yes	Yes	5	9	8
34	R:R:L73	R:R:N34	9.61	No	Yes	0	8	9
35	R:R:N34	R:R:P320	4.89	Yes	No	5	9	9
36	R:R:A37	R:R:I324	3.25	No	Yes	0	9	9
37	R:R:L38	R:R:T69	5.9	No	Yes	0	7	8
38	R:R:I324	R:R:L40	4.28	Yes	No	0	9	8
39	R:R:L40	R:R:S328	4.5	No	No	0	8	7
40	R:R:L41	R:R:Y62	7.03	No	Yes	6	9	7
41	R:R:C66	R:R:L41	7.94	No	No	6	6	9
42	R:R:I324	R:R:L41	5.71	Yes	No	0	9	9
43	R:R:P56	R:R:S44	8.91	No	No	0	3	7
44	R:R:L146	R:R:P58	3.28	Yes	No	0	4	6
45	R:R:S59	R:R:Y62	3.82	No	Yes	0	7	7
46	R:R:E129	R:R:V60	4.28	No	Yes	3	9	7
47	R:R:V60	R:R:Y140	3.79	Yes	Yes	3	7	8
48	R:R:I144	R:R:V60	3.07	No	Yes	3	5	7
49	R:R:F61	R:R:V65	7.87	No	No	0	9	8
50	R:R:C66	R:R:Y62	8.06	No	Yes	6	6	7
51	R:R:L146	R:R:M63	4.24	Yes	No	0	4	6
52	R:R:L64	R:R:M126	5.65	No	Yes	0	8	9
53	R:R:M126	R:R:V65	3.04	Yes	No	0	9	8
54	R:R:I324	R:R:V65	3.07	Yes	No	0	9	8
55	R:R:D72	R:R:L68	5.43	Yes	Yes	0	9	9
56	R:R:L68	R:R:Q122	7.99	Yes	No	0	9	7
57	R:R:L123	R:R:L68	5.54	No	Yes	2	8	9
58	R:R:L68	R:R:M126	5.65	Yes	Yes	0	9	9
59	R:R:D319	R:R:L68	6.79	Yes	Yes	2	9	9
60	R:R:P320	R:R:T69	3.5	No	Yes	5	9	8
61	R:R:Q122	R:R:T71	8.5	No	No	0	7	9
62	R:R:D72	R:R:S119	7.36	Yes	No	0	9	8
63	R:R:D72	R:R:S316	8.83	Yes	No	0	9	8
64	R:R:F115	R:R:G75	9.03	Yes	No	0	8	9
65	R:R:K76	R:R:S80	3.06	Yes	Yes	1	8	8
66	R:R:K76	R:R:S316	6.12	Yes	No	0	8	8
67	R:R:I317	R:R:K76	4.36	Yes	Yes	0	9	8
68	L:L:?1	R:R:K76	13.91	Yes	Yes	1	0	8
69	R:R:F111	R:R:L78	7.31	No	No	0	5	6
70	R:R:F108	R:R:L79	12.18	Yes	No	1	6	6
71	R:R:L79	R:R:M112	4.24	No	Yes	1	6	8
72	L:L:?1	R:R:L79	7.28	Yes	No	1	0	6
73	R:R:P81	R:R:S80	3.56	No	Yes	1	8	8
74	L:L:?1	R:R:S80	8.89	Yes	Yes	1	0	8
75	R:R:L93	R:R:V82	5.96	No	No	1	6	6
76	R:R:L104	R:R:V82	4.47	Yes	No	1	5	6
77	R:R:F108	R:R:V82	7.87	Yes	No	1	6	6
78	R:R:F108	R:R:V83	3.93	Yes	No	0	6	9
79	R:R:T181	R:R:V83	3.17	No	No	0	9	9
80	L:L:?1	R:R:V83	7.84	Yes	No	0	0	9
81	R:R:A85	R:R:L96	3.15	No	No	0	6	4
82	R:R:A86	R:R:T181	3.36	No	No	0	6	9
83	R:R:P179	R:R:Y87	4.17	Yes	Yes	1	8	8
84	R:R:T181	R:R:Y87	17.48	No	Yes	0	9	8
85	L:L:?1	R:R:Y87	6.17	Yes	Yes	1	0	8
86	R:R:Q89	R:R:R91	17.52	No	No	0	5	3
87	R:R:L96	R:R:Q89	7.99	No	No	0	4	5
88	R:R:S92	R:R:V95	3.23	No	No	4	5	2
89	R:R:Q176	R:R:S92	7.22	Yes	No	0	5	5
90	R:R:L104	R:R:L93	5.54	Yes	No	1	5	6
91	R:R:F108	R:R:L93	4.87	Yes	No	1	6	6
92	R:R:N102	R:R:R94	10.85	No	No	0	1	2
93	R:R:Q176	R:R:R94	4.67	Yes	No	0	5	2
94	R:R:A97	R:R:D101	6.18	No	No	0	1	4
95	R:R:A99	R:R:D101	3.09	No	No	0	5	4
96	R:R:D101	R:R:S103	4.42	No	No	0	4	3
97	R:R:C105	R:R:Q106	3.05	No	No	0	9	4
98	R:R:F174	R:R:Q106	8.2	Yes	No	0	6	4
99	R:R:F108	R:R:M112	3.73	Yes	Yes	1	6	8
100	R:R:A109	R:R:F174	9.71	No	Yes	0	8	6
101	R:R:C164	R:R:F110	4.19	No	No	0	8	7
102	R:R:F110	R:R:F168	9.65	No	No	0	7	4
103	R:R:F111	R:R:F115	5.36	No	Yes	0	5	8
104	R:R:F184	R:R:M112	8.71	Yes	Yes	1	8	8
105	L:L:?1	R:R:M112	9.3	Yes	Yes	1	0	8
106	R:R:F184	R:R:S113	5.28	Yes	No	1	8	7
107	R:R:I185	R:R:S113	4.64	Yes	No	1	7	7
108	R:R:S113	R:R:Y203	3.82	No	Yes	1	7	8
109	R:R:F114	R:R:F115	16.08	Yes	Yes	0	7	8
110	R:R:F114	R:R:S118	5.28	Yes	Yes	1	7	7
111	R:R:F114	R:R:S160	3.96	Yes	No	1	7	7
112	R:R:F114	R:R:L161	8.53	Yes	No	0	7	3
113	R:R:L117	R:R:L121	6.92	Yes	Yes	0	8	5
114	R:R:L117	R:R:S160	6.01	Yes	No	1	8	7
115	R:R:F163	R:R:L117	4.87	Yes	Yes	1	7	8
116	R:R:L117	R:R:L206	4.15	Yes	Yes	1	8	5
117	R:R:S118	R:R:V156	3.23	Yes	No	0	7	6
118	R:R:S118	R:R:S160	6.52	Yes	No	1	7	7
119	R:R:M207	R:R:T120	6.02	No	No	0	7	7
120	R:R:L210	R:R:T120	5.9	Yes	No	0	6	7
121	R:R:L121	R:R:V156	7.45	Yes	No	0	5	6
122	R:R:L121	R:R:L210	5.54	Yes	Yes	0	5	6
123	R:R:F274	R:R:L123	3.65	Yes	No	2	9	8
124	R:R:D319	R:R:L123	9.5	Yes	No	2	9	8
125	R:R:L124	R:R:L210	4.15	No	Yes	0	5	6
126	R:R:A213	R:R:L124	4.73	No	No	0	6	5
127	R:R:L124	R:R:T214	7.37	No	No	0	5	8
128	R:R:F323	R:R:M126	7.46	No	Yes	0	9	9
129	R:R:A127	R:R:N218	3.13	No	No	0	9	9
130	R:R:L128	R:R:L132	6.92	No	Yes	0	7	5
131	R:R:C217	R:R:L128	3.17	No	No	0	7	7
132	R:R:E129	R:R:Y140	8.98	No	Yes	3	9	8
133	R:R:C130	R:R:L134	3.17	No	No	0	9	8
134	R:R:L132	R:R:W131	5.69	Yes	No	0	5	6
135	R:R:H136	R:R:W131	8.46	No	No	0	4	6
136	R:R:F139	R:R:L132	3.65	No	Yes	0	5	5
137	R:R:S133	R:R:Y140	16.53	No	Yes	0	9	8
138	R:R:L134	R:R:L225	4.15	No	No	0	8	9
139	R:R:G135	R:R:H136	3.18	No	No	0	7	4
140	R:R:G135	R:R:N224	5.09	No	No	0	7	7
141	R:R:F139	R:R:H143	16.97	No	No	0	5	5
142	R:R:I144	R:R:Y140	18.13	No	Yes	3	5	8
143	R:R:H143	R:R:R142	4.51	No	No	0	5	5
144	R:R:L151	R:R:R147	3.64	No	No	0	3	4
145	R:R:G149	R:R:V152	3.68	No	No	0	7	5
146	R:R:F163	R:R:Y199	4.13	Yes	Yes	1	7	6
147	R:R:F163	R:R:L202	6.09	Yes	No	0	7	5
148	R:R:F163	R:R:Y203	4.13	Yes	Yes	1	7	8
149	R:R:F163	R:R:L206	6.09	Yes	Yes	1	7	5
150	R:R:F171	R:R:L166	3.65	No	No	1	4	7
151	R:R:L166	R:R:Y199	5.86	No	Yes	1	7	6
152	R:R:G172	R:R:P167	4.06	No	No	1	8	9
153	R:R:F174	R:R:P167	8.67	Yes	No	0	6	9
154	R:R:P167	R:R:Y199	16.69	No	Yes	1	9	6
155	R:R:F168	R:R:F174	3.22	No	Yes	0	4	6
156	R:R:F171	R:R:Y199	9.28	No	Yes	1	4	6
157	R:R:G172	R:R:Y199	4.35	No	Yes	1	8	6
158	R:R:K173	R:R:Q186	8.14	No	Yes	1	2	5
159	R:R:K173	R:R:V196	4.55	No	Yes	1	2	5
160	R:R:F174	R:R:I185	5.02	Yes	Yes	0	6	7
161	R:R:Q186	R:R:V175	10.03	Yes	No	1	5	4
162	R:R:G180	R:R:Q176	6.58	No	Yes	0	6	5
163	R:R:C183	R:R:Q176	4.58	No	Yes	0	9	5
164	R:R:W182	R:R:Y177	26.04	Yes	Yes	1	9	9
165	R:R:F184	R:R:Y177	4.13	Yes	Yes	1	8	9
166	R:R:M187	R:R:Y177	4.79	No	Yes	1	7	9
167	R:R:D305	R:R:Y177	6.9	No	Yes	1	7	9
168	R:R:C178	R:R:P179	3.77	No	Yes	1	4	8
169	R:R:C178	R:R:E302	9.12	No	No	1	4	3
170	R:R:P179	R:R:W182	6.76	Yes	Yes	1	8	9
171	R:R:L306	R:R:W182	4.56	No	Yes	1	7	9
172	R:R:L309	R:R:W182	3.42	No	Yes	0	7	9
173	L:L:?1	R:R:W182	14.98	Yes	Yes	1	0	9
174	R:R:F184	R:R:I185	6.28	Yes	Yes	1	8	7
175	R:R:F184	R:R:M187	3.73	Yes	No	1	8	7
176	R:R:F184	R:R:L309	7.31	Yes	No	0	8	7
177	R:R:I185	R:R:Y199	10.88	Yes	Yes	1	7	6
178	R:R:I185	R:R:S200	3.1	Yes	No	0	7	7
179	R:R:I185	R:R:Y203	7.25	Yes	Yes	1	7	8
180	R:R:Q186	R:R:V196	7.16	Yes	Yes	1	5	5
181	R:R:D305	R:R:M187	4.16	No	No	1	7	7
182	R:R:H189	R:R:V188	5.54	No	No	0	4	3
183	R:R:G192	R:R:H189	3.18	No	No	0	1	4
184	R:R:H189	R:R:L197	5.14	No	No	0	4	4
185	R:R:E190	R:R:E191	5.07	No	No	0	1	1
186	R:R:E190	R:R:S193	4.31	No	No	1	1	3
187	R:R:E190	R:R:V196	7.13	No	Yes	1	1	5
188	R:R:S193	R:R:V196	6.46	No	Yes	1	3	5
189	R:R:L197	R:R:V201	7.45	No	No	0	4	4
190	R:R:A289	R:R:L197	3.15	No	No	0	7	4
191	R:R:F290	R:R:V201	6.55	No	No	0	3	4
192	R:R:M207	R:R:Y203	10.78	No	Yes	0	7	8
193	R:R:I282	R:R:S204	4.64	No	No	7	8	8
194	R:R:A285	R:R:S204	3.42	No	No	0	7	8
195	R:R:S204	R:R:Y286	13.99	No	Yes	7	8	5
196	R:R:S205	R:R:Y286	5.09	No	Yes	0	4	5
197	R:R:L206	R:R:L210	5.54	Yes	Yes	0	5	6
198	R:R:A208	R:R:I282	3.25	No	No	0	6	8
199	R:R:F274	R:R:V211	7.87	Yes	No	2	9	8
200	R:R:S278	R:R:V211	4.85	No	No	2	9	8
201	R:R:N218	R:R:T214	4.39	No	No	0	9	8
202	R:R:F274	R:R:T214	3.89	Yes	No	0	9	8
203	R:R:T271	R:R:V215	4.76	No	No	0	8	6
204	R:R:N218	R:R:T271	13.16	No	No	0	9	8
205	R:R:L267	R:R:M222	4.24	No	Yes	0	9	7
206	R:R:E260	R:R:L225	3.98	Yes	No	0	9	9
207	R:R:L225	R:R:L264	8.3	No	No	0	9	7
208	R:R:R230	R:R:Y226	7.2	No	No	0	5	5
209	R:R:M228	R:R:R231	4.96	No	No	0	8	5
210	R:R:E260	R:R:M228	6.77	Yes	No	0	9	8
211	R:R:H229	R:R:Q233	7.42	No	No	0	6	3
212	R:R:E260	R:R:H229	3.69	Yes	No	0	9	6
213	R:R:H229	R:R:L261	5.14	No	No	0	6	5
214	R:R:Q233	R:R:R230	11.68	No	No	0	3	5
215	R:R:E260	R:R:L232	5.3	Yes	No	0	9	5
216	R:R:H235	R:R:P236	3.05	No	No	0	4	4
217	R:R:P257	R:R:Q256	3.16	No	No	0	6	5
218	R:R:E259	R:R:L258	3.98	No	No	0	6	6
219	R:R:D262	R:R:L258	13.57	No	No	0	9	6
220	R:R:E259	R:R:E260	5.07	No	Yes	0	6	9
221	R:R:E259	R:R:L261	6.63	No	No	0	6	5
222	R:R:H263	R:R:R327	3.39	No	No	0	8	9
223	R:R:L266	R:R:R327	10.93	No	No	0	8	9
224	R:R:M270	R:R:V318	3.04	Yes	No	0	9	8
225	R:R:D319	R:R:M270	4.16	Yes	Yes	2	9	9
226	R:R:I322	R:R:M270	7.29	Yes	Yes	0	8	9
227	R:R:F323	R:R:M270	4.98	No	Yes	2	9	9
228	R:R:L273	R:R:V318	5.96	No	No	0	8	8
229	R:R:F274	R:R:S278	7.93	Yes	No	2	9	9
230	R:R:F274	R:R:I315	6.28	Yes	Yes	2	9	9
231	R:R:C277	R:R:V314	3.42	No	No	0	9	4
232	R:R:C277	R:R:I315	4.91	No	Yes	0	9	9
233	R:R:I315	R:R:S278	4.64	Yes	No	2	9	9
234	R:R:L312	R:R:V281	5.96	No	No	0	8	8
235	R:R:I282	R:R:Y286	4.84	No	Yes	7	8	5
236	R:R:R284	R:R:Y283	3.09	Yes	No	0	5	6
237	R:R:Y283	R:R:Y287	3.97	No	Yes	0	6	4
238	R:R:E301	R:R:R284	12.79	Yes	Yes	1	3	5
239	R:R:E304	R:R:R284	17.45	No	Yes	1	1	5
240	R:R:D305	R:R:R284	13.1	No	Yes	1	7	5
241	R:R:F290	R:R:Y286	8.25	No	Yes	0	3	5
242	R:R:K291	R:R:Y287	5.97	No	Yes	0	3	4
243	R:R:E301	R:R:Y287	5.61	Yes	Yes	0	3	4
244	R:R:A289	R:R:F290	8.32	No	No	0	7	3
245	R:R:D292	R:R:E295	22.09	No	No	0	2	1
246	R:R:K294	R:R:V293	3.04	No	No	0	1	1
247	R:R:E295	R:R:E301	8.88	No	Yes	1	1	3
248	R:R:N297	R:R:S300	10.43	No	No	0	3	1
249	R:R:E301	R:R:E304	3.81	Yes	No	1	3	1
250	R:R:L306	R:R:R310	14.58	No	No	1	7	9
251	L:L:?1	R:R:L306	4.55	Yes	No	1	0	7
252	R:R:F311	R:R:R307	3.21	No	No	0	6	4
253	L:L:?1	R:R:R310	9.59	Yes	No	1	0	9
254	L:L:?1	R:R:S313	9.88	Yes	No	0	0	9
255	R:R:D319	R:R:I315	5.6	Yes	Yes	2	9	9
256	R:R:D319	R:R:F323	5.97	Yes	No	2	9	9
257	R:R:I325	R:R:W321	15.27	No	No	0	8	8
258	R:R:F326	R:R:W321	4.01	No	No	0	5	8
259	R:R:F326	R:R:I322	6.28	No	Yes	0	5	8
260	R:R:F331	R:R:I325	7.54	No	No	0	7	8
261	R:R:F326	R:R:F331	5.36	No	No	0	5	7
262	R:R:P329	R:R:R332	5.76	No	No	0	7	6
263	R:R:F331	R:R:F335	10.72	No	No	0	7	4
264	R:R:F334	R:R:I333	3.77	No	No	0	4	5
265	R:R:F171	R:R:G198	3.01	No	No	0	4	4
266	R:R:L64	R:R:V60	2.98	No	Yes	0	8	7
267	R:R:L146	R:R:V60	2.98	Yes	Yes	0	4	7
268	R:R:L64	R:R:V152	2.98	No	No	0	8	5
269	R:R:L219	R:R:V215	2.98	No	No	0	5	6
270	R:R:I317	R:R:L26	2.85	Yes	No	0	9	8
271	R:R:I325	R:R:L36	2.85	No	No	0	8	5
272	R:R:I144	R:R:L132	2.85	No	Yes	0	5	5
273	R:R:I322	R:R:L266	2.85	Yes	No	0	8	8
274	R:R:L166	R:R:M169	2.83	No	No	0	7	3
275	R:R:L219	R:R:M222	2.83	No	Yes	0	5	7
276	R:R:L264	R:R:M222	2.83	No	Yes	0	7	7
277	R:R:G220	R:R:W131	2.81	No	No	0	5	6
278	R:R:C105	R:R:R94	2.79	No	No	0	9	2
279	R:R:L104	R:R:L96	2.77	Yes	No	0	5	4
280	R:R:A165	R:R:F168	2.77	No	No	0	5	4
281	R:R:L212	R:R:L216	2.77	No	No	0	3	4
282	R:R:A308	R:R:R284	2.77	No	Yes	0	7	5
283	R:R:I333	R:R:Q256	2.74	No	No	0	5	5
284	R:R:D72	R:R:N34	2.69	Yes	Yes	0	9	9
285	R:R:V14	R:R:Y87	2.52	No	Yes	0	4	8
286	R:R:F115	R:R:L74	2.44	Yes	No	0	8	4
287	R:R:F159	R:R:L121	2.44	No	Yes	0	4	5
288	R:R:F159	R:R:L206	2.44	No	Yes	0	4	5
289	R:R:L258	R:R:R332	2.43	No	No	0	6	6
290	R:R:E15	R:R:R7	2.33	No	Yes	1	3	4
291	R:R:F5	R:R:R298	2.14	Yes	No	0	4	1
292	R:R:R231	R:R:R234	2.13	No	No	0	5	3
293	R:R:G23	R:R:G24	2.11	No	No	0	8	4
294	R:R:C66	R:R:G67	1.96	No	No	0	6	6
295	R:R:A97	R:R:P98	1.87	No	No	0	1	5
296	R:R:A153	R:R:P154	1.87	No	No	0	7	4
297	R:R:A308	R:R:P280	1.87	No	No	0	7	9
298	R:R:G45	R:R:S44	1.86	No	No	0	6	7
299	L:L:?1	R:R:L312	1.82	Yes	No	0	0	8
300	R:R:A221	R:R:C130	1.81	No	No	0	9	9
301	R:R:G23	R:R:L26	1.71	No	No	0	8	8
302	R:R:G33	R:R:L32	1.71	No	No	0	9	4
303	R:R:G47	R:R:L46	1.71	No	No	0	5	4
304	R:R:A107	R:R:S103	1.71	No	No	0	5	3
305	R:R:G149	R:R:L148	1.71	No	No	0	7	5
306	R:R:A125	R:R:V152	1.7	No	No	0	7	5
307	R:R:L57	R:R:P58	1.64	No	No	0	7	6
308	R:R:L279	R:R:P280	1.64	No	No	0	7	9
309	R:R:S118	R:R:S157	1.63	Yes	No	0	7	6
310	R:R:S193	R:R:S195	1.63	No	No	0	3	1
311	R:R:S19	R:R:V21	1.62	No	No	0	6	3
312	R:R:S328	R:R:V330	1.62	No	No	0	7	7
313	R:R:A150	R:R:M63	1.61	No	No	0	5	6
314	R:R:A268	R:R:M222	1.61	No	Yes	0	6	7
315	R:R:S28	R:R:T29	1.6	No	No	0	4	6
316	R:R:T29	R:R:V25	1.59	No	No	0	6	4
317	R:R:T69	R:R:V70	1.59	Yes	No	0	8	5
318	R:R:C77	R:R:L73	1.59	No	No	0	6	8
319	R:R:C77	R:R:L78	1.59	No	No	0	6	6
320	R:R:T275	R:R:V215	1.59	No	No	0	5	6
321	R:R:A97	R:R:L104	1.58	No	Yes	0	1	5
322	R:R:P329	R:R:Q256	1.58	No	No	0	7	5
323	R:R:H136	R:R:P137	1.53	No	No	0	4	9
324	R:R:A153	R:R:Q122	1.52	No	No	0	7	7
325	R:R:M276	R:R:V272	1.52	No	No	0	5	5
326	R:R:M276	R:R:T275	1.51	No	No	0	5	5
327	R:R:G220	R:R:R223	1.5	No	No	0	5	4
328	R:R:L146	R:R:T145	1.47	Yes	No	0	4	6
329	R:R:N297	R:R:T299	1.46	No	No	0	3	1
330	R:R:G45	R:R:Y62	1.45	No	Yes	0	6	7
331	R:R:G116	R:R:Y203	1.45	No	Yes	0	8	8
332	R:R:G288	R:R:Y287	1.45	No	Yes	0	7	4
333	R:R:P236	R:R:R234	1.44	No	No	0	4	3
334	R:R:F311	R:R:P280	1.44	No	No	0	6	9
335	R:R:E301	R:R:S300	1.44	Yes	No	0	3	1
336	R:R:I322	R:R:L269	1.43	Yes	No	0	8	5
337	R:R:A227	R:R:R231	1.38	No	No	0	4	5
338	R:R:A303	R:R:R307	1.38	No	No	0	1	4
339	R:R:D262	R:R:L265	1.36	No	No	0	9	6
340	R:R:R147	R:R:T145	1.29	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F5	6.702	5	1	4
2	R:R:Y6	8.04667	6	1	6
3	R:R:R7	4.1825	4	1	4
4	R:R:N34	5.76	4	5	9
5	R:R:V60	3.42	5	3	7
6	R:R:Y62	5.09	4	6	7
7	R:R:L68	6.28	5	2	9
8	R:R:T69	4.21	4	5	8
9	R:R:D72	6.0775	4	0	9
10	R:R:K76	6.8625	4	1	8
11	R:R:S80	6.85	4	1	8
12	R:R:Y87	8.16333	6	1	8
13	R:R:L104	3.59	4	1	5
14	R:R:F108	6.516	5	1	6
15	R:R:M112	6.495	4	1	8
16	R:R:F114	8.4625	4	1	7
17	R:R:F115	8.2275	4	0	8
18	R:R:L117	5.4875	4	1	8
19	R:R:S118	4.165	4	1	7
20	R:R:L121	5.5875	4	0	5
21	R:R:M126	5.45	4	0	9
22	R:R:L132	4.7775	4	0	5
23	R:R:Y140	11.8575	4	3	8
24	R:R:L146	2.9925	4	0	4
25	R:R:F163	5.062	5	1	7
26	R:R:F174	6.964	5	0	6
27	R:R:Q176	5.7625	4	0	5
28	R:R:Y177	9.166	5	1	9
29	R:R:P179	4.49	4	1	8
30	R:R:W182	11.152	5	1	9
31	R:R:F184	5.90667	6	1	8
32	R:R:I185	6.195	6	1	7
33	R:R:Q186	7.7425	4	1	5
34	R:R:V196	6.325	4	1	5
35	R:R:Y199	8.53167	6	1	6
36	R:R:Y203	5.486	5	1	8
37	R:R:L206	4.555	4	1	5
38	R:R:L210	5.2825	4	0	6
39	R:R:M222	2.8775	4	0	7
40	R:R:E260	4.962	5	0	9
41	R:R:M270	4.8675	4	2	9
42	R:R:F274	5.924	5	2	9
43	R:R:R284	9.84	5	1	5
44	R:R:Y286	8.0425	4	7	5
45	R:R:Y287	4.25	4	0	4
46	R:R:E301	6.005	6	1	3
47	R:R:I315	5.3575	4	2	9
48	R:R:I317	4.705	4	0	9
49	R:R:D319	6.404	5	2	9
50	R:R:I322	4.4625	4	0	8
51	R:R:I324	4.0775	4	0	9
52	L:L:?1	8.56455	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F5	R:R:Y6	14.9047	16.5	Yes	Yes	1	4	6
2	R:R:Y177	R:R:Y6	54.9902	3.97	Yes	Yes	1	9	6
3	R:R:Q186	R:R:Y6	10.0925	5.64	Yes	Yes	1	5	6
4	R:R:C178	R:R:R7	12.5123	5.57	No	Yes	1	4	4
5	R:R:C178	R:R:P179	16.6621	3.77	No	Yes	1	4	8
6	R:R:P179	R:R:W182	13.9604	6.76	Yes	Yes	1	8	9
7	R:R:W182	R:R:Y177	28.137	26.04	Yes	Yes	1	9	9
8	R:R:F184	R:R:Y177	60.0925	4.13	Yes	Yes	1	8	9
9	R:R:F184	R:R:I185	75.9553	6.28	Yes	Yes	1	8	7
10	R:R:F174	R:R:I185	20.5902	5.02	Yes	Yes	0	6	7
11	R:R:F174	R:R:Q106	14.7077	8.2	Yes	No	0	6	4
12	R:R:C105	R:R:Q106	13.2569	3.05	No	No	0	9	4
13	R:R:C105	R:R:R94	11.8006	2.79	No	No	0	9	2
14	L:L:?1	R:R:W182	28.1178	14.98	Yes	Yes	1	0	9
15	L:L:?1	R:R:Y87	12.7806	6.17	Yes	Yes	1	0	8
16	L:L:?1	R:R:K76	71.7617	13.91	Yes	Yes	1	0	8
17	R:R:K76	R:R:S316	70.5436	6.12	Yes	No	0	8	8
18	R:R:D72	R:R:S316	70.2754	8.83	Yes	No	0	9	8
19	R:R:D72	R:R:L68	68.1676	5.43	Yes	Yes	0	9	9
20	R:R:D319	R:R:L68	15.8081	6.79	Yes	Yes	2	9	9
21	R:R:D319	R:R:M270	19.5089	4.16	Yes	Yes	2	9	9
22	R:R:I322	R:R:M270	18.299	7.29	Yes	Yes	0	8	9
23	R:R:F326	R:R:I322	12.3645	6.28	No	Yes	0	5	8
24	R:R:I324	R:R:V65	13.6182	3.07	Yes	No	0	9	8
25	R:R:M126	R:R:V65	15.6438	3.04	Yes	No	0	9	8
26	R:R:L68	R:R:M126	42.4587	5.65	Yes	Yes	0	9	9
27	R:R:L64	R:R:M126	30.9811	5.65	No	Yes	0	8	9
28	R:R:L64	R:R:V60	26.3139	2.98	No	Yes	0	8	7
29	R:R:I144	R:R:V60	14.5544	3.07	No	Yes	3	5	7
30	R:R:L123	R:R:L68	28.8076	5.54	No	Yes	2	8	9
31	R:R:F114	R:R:S160	11.4174	3.96	Yes	No	1	7	7
32	R:R:L117	R:R:S160	16.9632	6.01	Yes	No	1	8	7
33	R:R:F163	R:R:L117	18.6631	4.87	Yes	Yes	1	7	8
34	R:R:F163	R:R:Y199	30.6389	4.13	Yes	Yes	1	7	6
35	R:R:I185	R:R:Y199	29.2675	10.88	Yes	Yes	1	7	6
36	R:R:F163	R:R:Y203	46.8986	4.13	Yes	Yes	1	7	8
37	R:R:I185	R:R:Y203	43.3456	7.25	Yes	Yes	1	7	8
38	R:R:S113	R:R:Y203	37.5725	3.82	No	Yes	1	7	8
39	R:R:F184	R:R:S113	37.901	5.28	Yes	No	1	8	7
40	R:R:F108	R:R:M112	39.5763	3.73	Yes	Yes	1	6	8
41	R:R:F184	R:R:M112	43.4742	8.71	Yes	Yes	1	8	8
42	L:L:?1	R:R:L79	12.9311	7.28	Yes	No	1	0	6
43	R:R:F108	R:R:L93	30.992	4.87	Yes	No	1	6	6
44	R:R:F108	R:R:V82	31.1699	7.87	Yes	No	1	6	6
45	R:R:L104	R:R:V82	28.6023	4.47	Yes	No	1	5	6
46	R:R:L104	R:R:L93	28.6023	5.54	Yes	No	1	5	6
47	L:L:?1	R:R:V83	14.9458	7.84	Yes	No	0	0	9
48	R:R:L104	R:R:L96	20.8776	2.77	Yes	No	0	5	4
49	R:R:L96	R:R:Q89	10.4484	7.99	No	No	0	4	5
50	R:R:A97	R:R:L104	31.2849	1.58	No	Yes	0	1	5
51	R:R:A97	R:R:D101	20.8776	6.18	No	No	0	1	4
52	R:R:D101	R:R:S103	10.4484	4.42	No	No	0	4	3
53	R:R:F163	R:R:L206	56.3862	6.09	Yes	Yes	1	7	5
54	R:R:M207	R:R:Y203	33.3133	10.78	No	Yes	0	7	8
55	R:R:M207	R:R:T120	32.6125	6.02	No	No	0	7	7
56	R:R:L206	R:R:L210	55.9373	5.54	Yes	Yes	0	5	6
57	R:R:L210	R:R:T120	32.0951	5.9	Yes	No	0	6	7
58	R:R:F274	R:R:L123	32.7056	3.65	Yes	No	2	9	8
59	R:R:L124	R:R:L210	90.4577	4.15	No	Yes	0	5	6
60	R:R:L124	R:R:T214	86.4995	7.37	No	No	0	5	8
61	R:R:N218	R:R:T214	100	4.39	No	No	0	9	8
62	R:R:I144	R:R:L132	13.7332	2.85	No	Yes	0	5	5
63	R:R:L225	R:R:L264	70.7654	8.3	No	No	0	9	7
64	R:R:L264	R:R:M222	73.2317	2.83	No	Yes	0	7	7
65	R:R:L219	R:R:M222	80.5978	2.83	No	Yes	0	5	7
66	R:R:L219	R:R:V215	83.0423	2.98	No	No	0	5	6
67	R:R:T271	R:R:V215	92.7653	4.76	No	No	0	8	6
68	R:R:N218	R:R:T271	95.1823	13.16	No	No	0	9	8
69	R:R:D305	R:R:Y177	26.3386	6.9	No	Yes	1	7	9
70	R:R:D305	R:R:R284	42.434	13.1	No	Yes	1	7	5
71	R:R:E301	R:R:R284	16.4541	12.79	Yes	Yes	1	3	5
72	R:R:E301	R:R:F5	10.5688	3.5	Yes	Yes	1	3	4
73	R:R:H189	R:R:V188	26.626	5.54	No	No	0	4	3
74	R:R:H189	R:R:L197	23.916	5.14	No	No	0	4	4
75	R:R:L197	R:R:V201	11.2778	7.45	No	No	0	4	4
76	R:R:A289	R:R:L197	11.2778	3.15	No	No	0	7	4
77	R:R:F290	R:R:Y286	16.9632	8.25	No	Yes	0	3	5
78	R:R:E260	R:R:L225	61.0123	3.98	Yes	No	0	9	9
79	R:R:E260	R:R:H229	12.9886	3.69	Yes	No	0	9	6
80	R:R:E260	R:R:M228	15.6247	6.77	Yes	No	0	9	8
81	R:R:M228	R:R:R231	13.0406	4.96	No	No	0	8	5
82	R:R:E259	R:R:E260	28.293	5.07	No	Yes	0	6	9
83	R:R:E259	R:R:L258	23.27	3.98	No	No	0	6	6
84	R:R:L258	R:R:R332	15.5015	2.43	No	No	0	6	6
85	R:R:P329	R:R:R332	13.0817	5.76	No	No	0	7	6
86	R:R:P329	R:R:Q256	10.4757	1.58	No	No	0	7	5
87	R:R:E301	R:R:Y287	10.963	5.61	Yes	Yes	0	3	4
88	R:R:E301	R:R:S300	10.9767	1.44	Yes	No	0	3	1
89	R:R:A308	R:R:P280	11.9183	1.87	No	No	0	7	9
90	R:R:A308	R:R:R284	14.2861	2.77	No	Yes	0	7	5
91	R:R:V188	R:R:Y6	26.7546	8.83	No	Yes	1	3	6
92	R:R:D305	R:R:M187	18.1622	4.16	No	No	1	7	7
93	R:R:F184	R:R:M187	19.3474	3.73	Yes	No	1	8	7
94	R:R:F108	R:R:V83	14.2067	3.93	Yes	No	0	6	9
95	R:R:F108	R:R:L79	12.3207	12.18	Yes	No	1	6	6
96	L:L:?1	R:R:M112	27.4718	9.3	Yes	Yes	1	0	8
97	R:R:F274	R:R:T214	37.2495	3.89	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N18	R:R:Y87	9.3	1	No	Yes	3	8	2	1
R:R:N18	R:R:P179	3.26	1	No	Yes	3	8	2	2
R:R:A20	R:R:Y87	9.34	0	No	Yes	6	8	2	1
R:R:M22	R:R:R310	14.89	0	No	No	3	9	2	1
R:R:F27	R:R:S80	11.89	1	No	Yes	8	8	2	1
R:R:F27	R:R:P81	5.78	1	No	No	8	8	2	2
R:R:K76	R:R:S80	3.06	1	Yes	Yes	8	8	1	1
R:R:K76	R:R:S316	6.12	1	Yes	No	8	8	1	2
R:R:I317	R:R:K76	4.36	0	Yes	Yes	9	8	2	1
L:L:?1	R:R:K76	13.91	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:L79	12.18	1	Yes	No	6	6	2	1
R:R:L79	R:R:M112	4.24	1	No	Yes	6	8	1	1
L:L:?1	R:R:L79	7.28	1	Yes	No	0	6	0	1
R:R:P81	R:R:S80	3.56	1	No	Yes	8	8	2	1
L:L:?1	R:R:S80	8.89	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:V83	3.93	1	Yes	No	6	9	2	1
R:R:T181	R:R:V83	3.17	0	No	No	9	9	2	1
L:L:?1	R:R:V83	7.84	1	Yes	No	0	9	0	1
R:R:P179	R:R:Y87	4.17	1	Yes	Yes	8	8	2	1
R:R:T181	R:R:Y87	17.48	0	No	Yes	9	8	2	1
L:L:?1	R:R:Y87	6.17	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:M112	3.73	1	Yes	Yes	6	8	2	1
R:R:F184	R:R:M112	8.71	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:M112	9.3	1	Yes	Yes	0	8	0	1
R:R:W182	R:R:Y177	26.04	1	Yes	Yes	9	9	1	2
R:R:F184	R:R:Y177	4.13	1	Yes	Yes	8	9	2	2
R:R:P179	R:R:W182	6.76	1	Yes	Yes	8	9	2	1
R:R:L306	R:R:W182	4.56	1	No	Yes	7	9	1	1
R:R:L309	R:R:W182	3.42	0	No	Yes	7	9	2	1
L:L:?1	R:R:W182	14.98	1	Yes	Yes	0	9	0	1
R:R:F184	R:R:L309	7.31	1	Yes	No	8	7	2	2
R:R:L312	R:R:V281	5.96	0	No	No	8	8	1	2
R:R:L306	R:R:R310	14.58	1	No	No	7	9	1	1
L:L:?1	R:R:L306	4.55	1	Yes	No	0	7	0	1
L:L:?1	R:R:R310	9.59	1	Yes	No	0	9	0	1
L:L:?1	R:R:S313	9.88	1	Yes	No	0	9	0	1
R:R:V14	R:R:Y87	2.52	0	No	Yes	4	8	2	1
L:L:?1	R:R:L312	1.82	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZW0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	290
Number of Links	340
Number of Hubs	52
Number of Links mediated by Hubs	195
Number of Communities	7
Number of Nodes involved in Communities	79
Number of Links involved in Communities	112

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	98352
Length Of Smallest Path	3
Average Path Length	15.0708
Length of Longest Path	33
Minimum Path Strength	1.38
Average Path Strength	6.20885
Maximum Path Strength	18.31
Minimum Path Correlation	0.7
Average Path Correlation	0.932982
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.4947
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.2492
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • prostanoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin D receptor activity • prostaglandin receptor activity • prostaglandin J receptor activity • multicellular organismal process • sleep • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • developmental process • multicellular organism development • sex determination • male sex determination • reproductive process • anatomical structure development • developmental process involved in reproduction • defense response • response to stress • inflammatory response • cellular response to prostaglandin D stimulus • response to prostaglandin D • carbohydrate derivative metabolic process • primary metabolic process • nucleoside metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • adenosine metabolic process • nucleobase-containing small molecule metabolic process • metabolic process • small molecule metabolic process • purine nucleoside metabolic process • ribonucleoside metabolic process • purine ribonucleoside metabolic process • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PG2
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PG2
Name	Prostaglandin D2
Synonyms	(5E,13E)-9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	448457
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13258
Sequence	>8ZW0_nogp_Chain_R P F Y R C Q N T T S V E K G N S A V M G G V L F S T G L L G N L L A L G L L A R S G L G P L P S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N R S L R V L A P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H P F F Y R R H I T L R L G A L V A P V V S A F S L A F C A L P F M G F G K F V Q Y C P G T W C F I Q M V H E E G S L S V L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K D V K E K N R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P V F R I F F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9UWD	A	Lipid	Prostaglandin	DP₁	Homo sapiens	-	-	-	-	2025-04-09	doi.org/10.1073/pnas.2501902122
	8ZVZ	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZVZ (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	9AU0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.45	2025-08-27	To be published
	9AU0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.45	2025-08-27	To be published

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