CodePG2
NameProstaglandin D2
Synonyms(5E,13E)-9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID
Identifier
FormulaC20 H32 O5
Molecular Weight352.465
SMILES
PubChem448457
Formal Charge0
Total Atoms57
Total Chiral Atoms4
Total Bonds57
Total Aromatic Bonds0
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZW0 A Lipid Prostaglandin DP1 Homo Sapiens PGD2 - Gs/Beta1/Gamma2 2.72 2025-05-28 doi.org/10.1073/pnas.2501902122

A 2D representation of the interactions of PG2 in 8ZW0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N18 R:R:Y87 9.3 1 No Yes 3 8 2 1
R:R:N18 R:R:P179 3.26 1 No Yes 3 8 2 2
R:R:A20 R:R:Y87 9.34 0 No Yes 6 8 2 1
R:R:M22 R:R:R310 14.89 0 No No 3 9 2 1
R:R:F27 R:R:S80 11.89 1 No Yes 8 8 2 1
R:R:F27 R:R:P81 5.78 1 No No 8 8 2 2
R:R:D72 R:R:S316 8.83 0 Yes No 9 8 2 1
R:R:K76 R:R:S80 3.06 1 Yes Yes 8 8 1 1
R:R:K76 R:R:S316 6.12 1 Yes No 8 8 1 1
R:R:I317 R:R:K76 4.36 0 Yes Yes 9 8 2 1
L:L:?1 R:R:K76 13.91 1 Yes Yes 0 8 0 1
R:R:F108 R:R:L79 12.18 1 Yes No 6 6 2 1
R:R:L79 R:R:M112 4.24 1 No Yes 6 8 1 1
L:L:?1 R:R:L79 7.28 1 Yes No 0 6 0 1
R:R:P81 R:R:S80 3.56 1 No Yes 8 8 2 1
L:L:?1 R:R:S80 8.89 1 Yes Yes 0 8 0 1
R:R:F108 R:R:V83 3.93 1 Yes No 6 9 2 1
R:R:T181 R:R:V83 3.17 0 No No 9 9 2 1
L:L:?1 R:R:V83 7.84 1 Yes No 0 9 0 1
R:R:P179 R:R:Y87 4.17 1 Yes Yes 8 8 2 1
R:R:T181 R:R:Y87 17.48 0 No Yes 9 8 2 1
L:L:?1 R:R:Y87 6.17 1 Yes Yes 0 8 0 1
R:R:F108 R:R:M112 3.73 1 Yes Yes 6 8 2 1
R:R:F108 R:R:W182 3.01 1 Yes Yes 6 9 2 1
R:R:F184 R:R:M112 8.71 1 Yes Yes 8 8 2 1
R:R:L309 R:R:M112 2.83 1 Yes Yes 7 8 1 1
L:L:?1 R:R:M112 9.3 1 Yes Yes 0 8 0 1
R:R:W182 R:R:Y177 26.04 1 Yes Yes 9 9 1 2
R:R:F184 R:R:Y177 4.13 1 Yes Yes 8 9 2 2
R:R:P179 R:R:W182 6.76 1 Yes Yes 8 9 2 1
R:R:L306 R:R:W182 4.56 1 No Yes 7 9 1 1
R:R:L309 R:R:W182 3.42 1 Yes Yes 7 9 1 1
L:L:?1 R:R:W182 14.98 1 Yes Yes 0 9 0 1
R:R:F184 R:R:L309 7.31 1 Yes Yes 8 7 2 1
R:R:L312 R:R:V281 5.96 0 No No 8 8 1 2
R:R:L306 R:R:R310 14.58 1 No No 7 9 1 1
L:L:?1 R:R:L306 4.55 1 Yes No 0 7 0 1
L:L:?1 R:R:L309 2.73 1 Yes Yes 0 7 0 1
L:L:?1 R:R:R310 9.59 1 Yes No 0 9 0 1
L:L:?1 R:R:S313 9.88 1 Yes No 0 9 0 1
L:L:?1 R:R:S316 2.96 1 Yes No 0 8 0 1
R:R:V14 R:R:Y87 2.52 0 No Yes 4 8 2 1
L:L:?1 R:R:L312 1.82 1 Yes No 0 8 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.68
Average Nodes In Shell28.00
Average Hubs In Shell13.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IYB A Lipid Prostanoid DP2 Homo Sapiens Prostaglandin A1D5Q Gi1/Beta1/Gamma2 2.82 2024-12-04 doi.org/10.1073/pnas.2403304121

A 2D representation of the interactions of PG2 in 9IYB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F87 12.02 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F90 25.63 1 Yes Yes 0 5 0 1
L:L:?1 R:R:H107 10.15 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F111 6.41 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F112 7.21 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R170 7.99 1 Yes Yes 0 5 0 1
L:L:?1 R:R:M181 20.46 1 Yes Yes 0 4 0 1
L:L:?1 R:R:C182 5.22 1 Yes No 0 9 0 1
L:L:?1 R:R:Y183 4.63 1 Yes Yes 0 4 0 1
L:L:?1 R:R:Y184 17.73 1 Yes Yes 0 4 0 1
L:L:?1 R:R:Y262 3.08 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L286 3.64 1 Yes No 0 5 0 1
R:R:M17 R:R:Y183 8.38 0 No Yes 7 4 2 1
R:R:F87 R:R:H39 3.39 1 Yes Yes 6 8 1 2
R:R:H107 R:R:S83 9.76 1 Yes No 5 6 1 2
R:R:F103 R:R:F86 16.08 1 Yes No 6 7 2 2
R:R:F86 R:R:H107 4.53 1 No Yes 7 5 2 1
R:R:F87 R:R:F90 3.22 1 Yes Yes 6 5 1 1
R:R:F87 R:R:L91 12.18 1 Yes Yes 6 5 1 2
R:R:F90 R:R:L91 3.65 1 Yes Yes 5 5 1 2
R:R:F90 R:R:W97 9.02 1 Yes Yes 5 9 1 2
R:R:F103 R:R:W97 6.01 1 Yes Yes 6 9 2 2
R:R:C104 R:R:W97 3.92 1 Yes Yes 9 9 2 2
R:R:F103 R:R:H107 4.53 1 Yes Yes 6 5 2 1
R:R:C104 R:R:S108 3.44 1 Yes No 9 5 2 2
R:R:C104 R:R:R170 5.57 1 Yes Yes 9 5 2 1
R:R:C104 R:R:C182 7.28 1 Yes No 9 9 2 1
R:R:K105 R:R:R170 3.71 0 No Yes 7 5 2 1
R:R:R170 R:R:S108 15.81 1 Yes No 5 5 1 2
R:R:F111 R:R:F112 9.65 1 Yes Yes 6 5 1 1
R:R:F111 R:R:Y262 8.25 1 Yes Yes 6 7 1 1
R:R:F111 R:R:F294 11.79 1 Yes No 6 6 1 2
R:R:F112 R:R:R170 5.34 1 Yes Yes 5 5 1 1
R:R:F112 R:R:K210 4.96 1 Yes Yes 5 5 1 2
R:R:F112 R:R:Y262 3.09 1 Yes Yes 5 7 1 1
R:R:R170 R:R:Y183 3.09 1 Yes Yes 5 4 1 1
R:R:R170 R:R:Y184 3.09 1 Yes Yes 5 4 1 1
R:R:I173 R:R:M181 4.37 1 No Yes 3 4 2 1
R:R:M181 R:R:R179 4.96 1 Yes Yes 4 1 1 2
R:R:M181 R:R:Y183 10.78 1 Yes Yes 4 4 1 1
R:R:Y183 R:R:Y184 17.87 1 Yes Yes 4 4 1 1
R:R:Q203 R:R:Y184 15.78 0 No Yes 3 4 2 1
R:R:K210 R:R:Y262 4.78 1 Yes Yes 5 7 2 1
R:R:V289 R:R:Y262 3.79 0 No Yes 7 7 2 1
R:R:T290 R:R:Y262 4.99 0 No Yes 6 7 2 1
R:R:L286 R:R:P287 3.28 0 No No 5 4 1 2
R:R:F294 R:R:T290 5.19 0 No No 6 6 2 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub10.00
Average Interaction Strength10.35
Average Nodes In Shell31.00
Average Hubs In Shell18.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.75
Average Number Of Links With An Hub6.75
Average Interaction Strength9.40
Average Nodes In Shell28.50
Average Hubs In Shell13.75
Average Links In Shell41.25
Average Links Mediated by Hubs In Shell37.50

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)