psnGPCR

Code	PG2
Name	Prostaglandin D2
Synonyms	(5E,13E)-9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID
Identifier
Formula	C20 H32 O5
Molecular Weight	352.465
SMILES
PubChem	448457
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	57
Total Aromatic Bonds	0
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8ZW0

Lipid

Prostaglandin

DP1

Homo Sapiens

PGD2

Gs/Beta1/Gamma2

2.72

2025-05-28

doi.org/10.1073/pnas.2501902122

A 2D representation of the interactions of PG2 in 8ZW0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N18	R:R:Y87	9.3	1	No	Yes	3	8	2	1
R:R:N18	R:R:P179	3.26	1	No	Yes	3	8	2	2
R:R:A20	R:R:Y87	9.34	0	No	Yes	6	8	2	1
R:R:M22	R:R:R310	14.89	0	No	No	3	9	2	1
R:R:F27	R:R:S80	11.89	1	No	Yes	8	8	2	1
R:R:F27	R:R:P81	5.78	1	No	No	8	8	2	2
R:R:D72	R:R:S316	8.83	0	Yes	No	9	8	2	1
R:R:K76	R:R:S80	3.06	1	Yes	Yes	8	8	1	1
R:R:K76	R:R:S316	6.12	1	Yes	No	8	8	1	1
R:R:I317	R:R:K76	4.36	0	Yes	Yes	9	8	2	1
L:L:?1	R:R:K76	13.91	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:L79	12.18	1	Yes	No	6	6	2	1
R:R:L79	R:R:M112	4.24	1	No	Yes	6	8	1	1
L:L:?1	R:R:L79	7.28	1	Yes	No	0	6	0	1
R:R:P81	R:R:S80	3.56	1	No	Yes	8	8	2	1
L:L:?1	R:R:S80	8.89	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:V83	3.93	1	Yes	No	6	9	2	1
R:R:T181	R:R:V83	3.17	0	No	No	9	9	2	1
L:L:?1	R:R:V83	7.84	1	Yes	No	0	9	0	1
R:R:P179	R:R:Y87	4.17	1	Yes	Yes	8	8	2	1
R:R:T181	R:R:Y87	17.48	0	No	Yes	9	8	2	1
L:L:?1	R:R:Y87	6.17	1	Yes	Yes	0	8	0	1
R:R:F108	R:R:M112	3.73	1	Yes	Yes	6	8	2	1
R:R:F108	R:R:W182	3.01	1	Yes	Yes	6	9	2	1
R:R:F184	R:R:M112	8.71	1	Yes	Yes	8	8	2	1
R:R:L309	R:R:M112	2.83	1	Yes	Yes	7	8	1	1
L:L:?1	R:R:M112	9.3	1	Yes	Yes	0	8	0	1
R:R:W182	R:R:Y177	26.04	1	Yes	Yes	9	9	1	2
R:R:F184	R:R:Y177	4.13	1	Yes	Yes	8	9	2	2
R:R:P179	R:R:W182	6.76	1	Yes	Yes	8	9	2	1
R:R:L306	R:R:W182	4.56	1	No	Yes	7	9	1	1
R:R:L309	R:R:W182	3.42	1	Yes	Yes	7	9	1	1
L:L:?1	R:R:W182	14.98	1	Yes	Yes	0	9	0	1
R:R:F184	R:R:L309	7.31	1	Yes	Yes	8	7	2	1
R:R:L312	R:R:V281	5.96	0	No	No	8	8	1	2
R:R:L306	R:R:R310	14.58	1	No	No	7	9	1	1
L:L:?1	R:R:L306	4.55	1	Yes	No	0	7	0	1
L:L:?1	R:R:L309	2.73	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R310	9.59	1	Yes	No	0	9	0	1
L:L:?1	R:R:S313	9.88	1	Yes	No	0	9	0	1
L:L:?1	R:R:S316	2.96	1	Yes	No	0	8	0	1
R:R:V14	R:R:Y87	2.52	0	No	Yes	4	8	2	1
L:L:?1	R:R:L312	1.82	1	Yes	No	0	8	0	1

Statistics	Value
Average Number Of Links	13.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	7.68
Average Nodes In Shell	28.00
Average Hubs In Shell	13.00
Average Links In Shell	43.00
Average Links Mediated by Hubs In Shell	38.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9IYB

Lipid

Prostanoid

DP2

Homo Sapiens

PGD2

A1D5Q

Gi1/Beta1/Gamma2

2.82

2024-12-04

doi.org/10.1073/pnas.2403304121

A 2D representation of the interactions of PG2 in 9IYB
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F87	12.02	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F90	25.63	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H107	10.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F111	6.41	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F112	7.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R170	7.99	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M181	20.46	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:C182	5.22	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y183	4.63	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y184	17.73	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y262	3.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L286	3.64	1	Yes	No	0	5	0	1
R:R:M17	R:R:Y183	8.38	0	No	Yes	7	4	2	1
R:R:F87	R:R:H39	3.39	1	Yes	Yes	6	8	1	2
R:R:H107	R:R:S83	9.76	1	Yes	No	5	6	1	2
R:R:F103	R:R:F86	16.08	1	Yes	No	6	7	2	2
R:R:F86	R:R:H107	4.53	1	No	Yes	7	5	2	1
R:R:F87	R:R:F90	3.22	1	Yes	Yes	6	5	1	1
R:R:F87	R:R:L91	12.18	1	Yes	Yes	6	5	1	2
R:R:F90	R:R:L91	3.65	1	Yes	Yes	5	5	1	2
R:R:F90	R:R:W97	9.02	1	Yes	Yes	5	9	1	2
R:R:F103	R:R:W97	6.01	1	Yes	Yes	6	9	2	2
R:R:C104	R:R:W97	3.92	1	Yes	Yes	9	9	2	2
R:R:F103	R:R:H107	4.53	1	Yes	Yes	6	5	2	1
R:R:C104	R:R:S108	3.44	1	Yes	No	9	5	2	2
R:R:C104	R:R:R170	5.57	1	Yes	Yes	9	5	2	1
R:R:C104	R:R:C182	7.28	1	Yes	No	9	9	2	1
R:R:K105	R:R:R170	3.71	0	No	Yes	7	5	2	1
R:R:R170	R:R:S108	15.81	1	Yes	No	5	5	1	2
R:R:F111	R:R:F112	9.65	1	Yes	Yes	6	5	1	1
R:R:F111	R:R:Y262	8.25	1	Yes	Yes	6	7	1	1
R:R:F111	R:R:F294	11.79	1	Yes	No	6	6	1	2
R:R:F112	R:R:R170	5.34	1	Yes	Yes	5	5	1	1
R:R:F112	R:R:K210	4.96	1	Yes	Yes	5	5	1	2
R:R:F112	R:R:Y262	3.09	1	Yes	Yes	5	7	1	1
R:R:R170	R:R:Y183	3.09	1	Yes	Yes	5	4	1	1
R:R:R170	R:R:Y184	3.09	1	Yes	Yes	5	4	1	1
R:R:I173	R:R:M181	4.37	1	No	Yes	3	4	2	1
R:R:M181	R:R:R179	4.96	1	Yes	Yes	4	1	1	2
R:R:M181	R:R:Y183	10.78	1	Yes	Yes	4	4	1	1
R:R:Y183	R:R:Y184	17.87	1	Yes	Yes	4	4	1	1
R:R:Q203	R:R:Y184	15.78	0	No	Yes	3	4	2	1
R:R:K210	R:R:Y262	4.78	1	Yes	Yes	5	7	2	1
R:R:V289	R:R:Y262	3.79	0	No	Yes	7	7	2	1
R:R:T290	R:R:Y262	4.99	0	No	Yes	6	7	2	1
R:R:L286	R:R:P287	3.28	0	No	No	5	4	1	2
R:R:F294	R:R:T290	5.19	0	No	No	6	6	2	2

Statistics	Value
Average Number Of Links	12.00
Average Number Of Links With An Hub	10.00
Average Interaction Strength	10.35
Average Nodes In Shell	31.00
Average Hubs In Shell	18.00
Average Links In Shell	47.00
Average Links Mediated by Hubs In Shell	45.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9E9S

Lipid

Prostanoid

DP1

Homo Sapiens

PGD2

Gs/Beta1/Gamma1

2.68

2025-09-03

To be published

A 2D representation of the interactions of PG2 in 9E9S
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L26	3.64	2	Yes	No	0	8	0	1
L:L:?1	R:R:K76	12.06	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:S80	10.86	2	Yes	No	0	8	0	1
L:L:?1	R:R:V83	7.84	2	Yes	No	0	9	0	1
L:L:?1	R:R:Y87	6.94	2	Yes	No	0	8	0	1
L:L:?1	R:R:M112	7.44	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:T181	4.85	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:W182	8.99	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:L306	4.55	2	Yes	No	0	7	0	1
L:L:?1	R:R:R310	5.59	2	Yes	No	0	9	0	1
L:L:?1	R:R:L312	4.55	2	Yes	No	0	8	0	1
L:L:?1	R:R:S313	13.83	2	Yes	No	0	9	0	1
R:R:A20	R:R:Y87	6.67	0	No	No	6	8	2	1
R:R:M22	R:R:R310	11.17	0	No	No	3	9	2	1
R:R:F27	R:R:S80	11.89	0	No	No	8	8	2	1
R:R:G30	R:R:K76	3.49	2	No	Yes	9	8	2	1
R:R:G30	R:R:I317	5.29	2	No	No	9	9	2	2
R:R:K76	R:R:S316	4.59	2	Yes	No	8	8	1	2
R:R:I317	R:R:K76	5.82	2	No	Yes	9	8	2	1
R:R:A86	R:R:T181	3.36	0	No	Yes	6	9	2	1
R:R:T181	R:R:Y87	14.98	2	Yes	No	9	8	1	1
R:R:F108	R:R:M112	3.73	0	Yes	Yes	6	8	2	1
R:R:F184	R:R:M112	6.22	2	Yes	Yes	8	8	2	1
R:R:L309	R:R:M112	4.24	2	Yes	Yes	7	8	2	1
R:R:W182	R:R:Y177	17.36	2	Yes	Yes	9	9	1	2
R:R:F184	R:R:Y177	5.16	2	Yes	Yes	8	9	2	2
R:R:P179	R:R:T181	5.25	0	No	Yes	8	9	2	1
R:R:L306	R:R:W182	5.69	2	No	Yes	7	9	1	1
R:R:L309	R:R:W182	7.97	2	Yes	Yes	7	9	2	1
R:R:F184	R:R:L309	6.09	2	Yes	Yes	8	7	2	2
R:R:L306	R:R:R310	12.15	2	No	No	7	9	1	1
R:R:L309	R:R:V281	2.98	2	Yes	No	7	8	2	2
R:R:L312	R:R:V281	2.98	0	No	No	8	8	1	2
L:L:?1	R:R:G23	2.25	2	Yes	No	0	8	0	1
L:L:?1	R:R:G116	2.25	2	Yes	No	0	8	0	1
R:R:G23	R:R:G24	2.11	0	No	No	8	4	1	2
R:R:P81	R:R:S80	1.78	0	No	No	8	8	2	1
R:R:T181	R:R:V14	1.59	2	Yes	No	9	4	1	2

Statistics	Value
Average Number Of Links	14.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	6.83
Average Nodes In Shell	31.00
Average Hubs In Shell	9.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	30.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	12.50
Average Number Of Links With An Hub	5.83
Average Interaction Strength	8.54
Average Nodes In Shell	29.33
Average Hubs In Shell	12.17
Average Links In Shell	40.50
Average Links Mediated by Hubs In Shell	35.33

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)