psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M1	R:R:N10	8.41	No	No	0	7	6
2	R:R:P4	R:R:S3	3.56	No	No	1	6	6
3	R:R:F5	R:R:S3	9.25	Yes	No	1	4	6
4	R:R:F5	R:R:P4	4.33	Yes	No	1	4	6
5	R:R:P4	R:R:R7	4.32	No	No	0	6	4
6	R:R:F5	R:R:Y6	10.32	Yes	Yes	1	4	6
7	R:R:F5	R:R:V188	5.24	Yes	No	0	4	3
8	R:R:E190	R:R:F5	4.66	No	Yes	0	1	4
9	R:R:F5	R:R:N297	3.62	Yes	No	0	4	3
10	R:R:Y177	R:R:Y6	7.94	Yes	Yes	1	9	6
11	R:R:Q186	R:R:Y6	5.64	Yes	Yes	1	5	6
12	R:R:E301	R:R:Y6	4.49	No	Yes	1	3	6
13	R:R:E302	R:R:Y6	5.61	No	Yes	1	3	6
14	R:R:D305	R:R:Y6	5.75	Yes	Yes	1	7	6
15	R:R:C178	R:R:C8	7.28	No	No	1	4	9
16	R:R:C8	R:R:E302	3.04	No	No	1	9	3
17	R:R:Q9	R:R:V175	5.73	No	Yes	0	2	4
18	R:R:N10	R:R:R94	7.23	No	Yes	0	6	2
19	R:R:R94	R:R:T12	2.59	Yes	No	0	2	5
20	R:R:K16	R:R:Y87	7.17	No	No	0	1	8
21	R:R:A20	R:R:Y87	9.34	No	No	0	6	8
22	R:R:G23	R:R:M22	3.49	No	No	0	8	3
23	R:R:M22	R:R:R310	2.48	No	No	0	3	9
24	R:R:F27	R:R:L31	4.87	No	No	0	8	6
25	R:R:F27	R:R:S80	17.18	No	No	0	8	8
26	R:R:S28	R:R:T29	3.2	No	No	0	4	6
27	R:R:T29	R:R:W321	3.64	No	No	0	6	8
28	R:R:G30	R:R:K76	5.23	No	Yes	2	9	8
29	R:R:G30	R:R:I317	3.53	No	No	2	9	9
30	R:R:L31	R:R:L35	4.15	No	No	2	6	5
31	R:R:G33	R:R:W321	7.04	No	No	0	9	8
32	R:R:D72	R:R:N34	8.08	No	Yes	2	9	9
33	R:R:L73	R:R:N34	10.98	Yes	Yes	2	8	9
34	R:R:K76	R:R:N34	6.99	Yes	Yes	2	8	9
35	R:R:N34	R:R:P320	4.89	Yes	No	0	9	9
36	R:R:I324	R:R:L36	5.71	No	No	0	9	5
37	R:R:A37	R:R:F323	2.77	No	No	0	9	9
38	R:R:A37	R:R:I324	3.25	No	No	0	9	9
39	R:R:L40	R:R:R327	6.07	No	Yes	0	8	9
40	R:R:C66	R:R:L41	6.35	No	No	0	6	9
41	R:R:F323	R:R:L41	9.74	No	No	0	9	9
42	R:R:R43	R:R:S44	7.91	No	No	4	5	7
43	R:R:R327	R:R:R43	5.33	Yes	No	4	9	5
44	R:R:R327	R:R:S44	6.59	Yes	No	4	9	7
45	R:R:E129	R:R:V60	4.28	No	No	0	9	7
46	R:R:F61	R:R:Y62	9.28	Yes	No	0	9	7
47	R:R:F61	R:R:V65	3.93	Yes	No	6	9	8
48	R:R:F61	R:R:M126	3.73	Yes	No	6	9	9
49	R:R:A263	R:R:F61	4.16	No	Yes	0	8	9
50	R:R:F61	R:R:L266	4.87	Yes	No	0	9	8
51	R:R:M126	R:R:V65	4.56	No	No	6	9	8
52	R:R:L68	R:R:Q122	6.65	No	Yes	0	9	7
53	R:R:L68	R:R:N319	2.75	No	Yes	0	9	9
54	R:R:Q122	R:R:T71	5.67	Yes	No	0	7	9
55	R:R:D72	R:R:K76	2.77	No	Yes	2	9	8
56	R:R:D72	R:R:S316	7.36	No	No	2	9	8
57	R:R:F115	R:R:G75	9.03	No	No	0	8	9
58	R:R:K76	R:R:S316	3.06	Yes	No	2	8	8
59	R:R:I317	R:R:K76	4.36	No	Yes	2	9	8
60	R:R:L78	R:R:L79	2.77	No	Yes	8	6	6
61	R:R:F111	R:R:L78	4.87	No	No	8	5	6
62	R:R:F108	R:R:L79	2.44	Yes	Yes	0	6	6
63	R:R:F111	R:R:L79	6.09	No	Yes	8	5	6
64	R:R:F115	R:R:L79	2.44	No	Yes	0	8	6
65	R:R:P81	R:R:S80	3.56	No	No	0	8	8
66	R:R:F108	R:R:V83	3.93	Yes	No	0	6	9
67	R:R:A86	R:R:L96	4.73	No	No	0	6	4
68	R:R:N90	R:R:Y87	4.65	No	No	0	5	8
69	R:R:Q89	R:R:R91	11.68	No	No	0	5	3
70	R:R:L96	R:R:R91	4.86	No	No	0	4	3
71	R:R:Q176	R:R:S92	2.89	No	No	9	5	5
72	R:R:G180	R:R:S92	3.71	No	No	9	6	5
73	R:R:L93	R:R:L96	2.77	No	No	0	6	4
74	R:R:L104	R:R:L93	5.54	No	No	0	5	6
75	R:R:F108	R:R:L93	2.44	Yes	No	0	6	6
76	R:R:R94	R:R:V95	2.62	Yes	No	0	2	2
77	R:R:N102	R:R:R94	10.85	No	Yes	0	1	2
78	R:R:A97	R:R:L100	4.73	No	No	0	1	4
79	R:R:Q106	R:R:S103	2.89	No	No	0	4	3
80	R:R:C105	R:R:Q176	3.05	No	No	0	9	5
81	R:R:C105	R:R:C183	7.28	No	No	0	9	9
82	R:R:F108	R:R:M112	2.49	Yes	No	0	6	8
83	R:R:C183	R:R:F108	4.19	No	Yes	0	9	6
84	R:R:A109	R:R:F174	9.71	No	Yes	0	8	6
85	R:R:A109	R:R:C183	3.61	No	No	0	8	9
86	R:R:F110	R:R:F111	5.36	Yes	No	0	7	5
87	R:R:F110	R:R:L161	2.44	Yes	No	0	7	3
88	R:R:C164	R:R:F110	2.79	No	Yes	0	8	7
89	R:R:I185	R:R:S113	3.1	Yes	No	0	7	7
90	R:R:S113	R:R:Y203	3.82	No	No	0	7	8
91	R:R:F114	R:R:F115	9.65	Yes	No	0	7	8
92	R:R:F114	R:R:S160	7.93	Yes	No	0	7	7
93	R:R:F114	R:R:L161	4.87	Yes	No	0	7	3
94	R:R:C164	R:R:F114	2.79	No	Yes	0	8	7
95	R:R:L117	R:R:S160	3	No	No	0	8	7
96	R:R:F163	R:R:L117	4.87	No	No	10	7	8
97	R:R:L117	R:R:L206	2.77	No	No	10	8	5
98	R:R:Q122	R:R:S118	2.89	Yes	Yes	7	7	7
99	R:R:S118	R:R:V156	3.23	Yes	No	7	7	6
100	R:R:S118	R:R:S160	3.26	Yes	No	0	7	7
101	R:R:F274	R:R:S119	6.61	Yes	No	0	9	8
102	R:R:L210	R:R:T120	5.9	No	No	0	6	7
103	R:R:F274	R:R:T120	2.59	Yes	No	0	9	7
104	R:R:L121	R:R:V156	7.45	No	No	0	5	6
105	R:R:F159	R:R:L121	2.44	No	No	0	4	5
106	R:R:L121	R:R:L210	4.15	No	No	0	5	6
107	R:R:Q122	R:R:V156	7.16	Yes	No	7	7	6
108	R:R:L123	R:R:T271	2.95	No	Yes	0	8	8
109	R:R:F274	R:R:L123	7.31	Yes	No	0	9	8
110	R:R:L124	R:R:T214	5.9	No	No	0	5	8
111	R:R:L267	R:R:M126	4.24	No	No	0	9	9
112	R:R:A127	R:R:L267	4.73	No	No	0	9	9
113	R:R:E129	R:R:S133	2.87	No	No	5	9	9
114	R:R:E129	R:R:Y140	3.37	No	No	5	9	8
115	R:R:R130	R:R:S133	3.95	No	No	0	9	9
116	R:R:E260	R:R:R130	8.14	No	No	0	9	9
117	R:R:A263	R:R:R130	4.15	No	No	0	8	9
118	R:R:H136	R:R:W131	3.17	No	No	0	4	6
119	R:R:G220	R:R:W131	2.81	No	No	0	5	6
120	R:R:A221	R:R:W131	3.89	No	No	0	9	6
121	R:R:F139	R:R:L132	4.87	No	No	0	5	5
122	R:R:S133	R:R:Y140	11.45	No	No	5	9	8
123	R:R:L134	R:R:L225	6.92	No	Yes	3	8	9
124	R:R:E260	R:R:L134	5.3	No	No	3	9	8
125	R:R:G135	R:R:N224	3.39	No	No	0	7	7
126	R:R:F138	R:R:R141	5.34	No	No	0	7	6
127	R:R:F139	R:R:H143	3.39	No	No	0	5	5
128	R:R:I144	R:R:Y140	4.84	No	No	0	5	8
129	R:R:R141	R:R:R142	3.2	No	No	0	6	5
130	R:R:H143	R:R:I144	3.98	No	No	0	5	5
131	R:R:H143	R:R:L148	2.57	No	No	0	5	5
132	R:R:L148	R:R:L151	4.15	No	No	0	5	3
133	R:R:F163	R:R:L202	3.65	No	No	0	7	5
134	R:R:F163	R:R:L206	3.65	No	No	10	7	5
135	R:R:L166	R:R:P167	3.28	No	No	0	7	9
136	R:R:F171	R:R:L166	4.87	Yes	No	0	4	7
137	R:R:F174	R:R:P167	8.67	Yes	No	0	6	9
138	R:R:P167	R:R:Y199	11.13	No	Yes	0	9	6
139	R:R:F171	R:R:S195	5.28	Yes	No	0	4	1
140	R:R:F171	R:R:G198	3.01	Yes	No	0	4	4
141	R:R:F171	R:R:Y199	4.13	Yes	Yes	0	4	6
142	R:R:G172	R:R:Y199	2.9	No	Yes	0	8	6
143	R:R:K173	R:R:V175	3.04	No	Yes	1	2	4
144	R:R:K173	R:R:Q186	16.27	No	Yes	1	2	5
145	R:R:F174	R:R:I185	3.77	Yes	Yes	0	6	7
146	R:R:V175	R:R:Y177	3.79	Yes	Yes	1	4	9
147	R:R:Q186	R:R:V175	12.89	Yes	Yes	1	5	4
148	R:R:G180	R:R:Q176	3.29	No	No	9	6	5
149	R:R:F184	R:R:Y177	7.22	No	Yes	0	8	9
150	R:R:D305	R:R:Y177	6.9	Yes	Yes	1	7	9
151	R:R:C178	R:R:E302	3.04	No	No	1	4	3
152	R:R:P179	R:R:W182	2.7	No	Yes	0	8	9
153	R:R:T181	R:R:W182	4.85	No	Yes	0	9	9
154	R:R:L306	R:R:W182	3.42	No	Yes	0	7	9
155	R:R:L309	R:R:W182	7.97	No	Yes	0	7	9
156	R:R:F184	R:R:I185	7.54	No	Yes	0	8	7
157	R:R:F184	R:R:L309	14.61	No	No	0	8	7
158	R:R:I185	R:R:Y199	6.04	Yes	Yes	0	7	6
159	R:R:Q186	R:R:V196	2.87	Yes	No	0	5	5
160	R:R:E190	R:R:H189	3.69	No	No	0	1	4
161	R:R:H189	R:R:V196	5.54	No	No	0	4	5
162	R:R:E190	R:R:G192	3.27	No	No	0	1	1
163	R:R:D292	R:R:E191	9.09	No	No	11	2	1
164	R:R:E191	R:R:V293	7.13	No	No	11	1	1
165	R:R:M207	R:R:Y203	5.99	No	No	0	7	8
166	R:R:I282	R:R:S204	4.64	No	No	0	8	8
167	R:R:A285	R:R:S204	3.42	No	No	0	7	8
168	R:R:L209	R:R:S205	3	No	No	0	3	4
169	R:R:L206	R:R:L210	2.77	No	No	0	5	6
170	R:R:T275	R:R:V211	7.93	No	No	0	5	8
171	R:R:T214	R:R:T271	4.71	No	Yes	0	8	8
172	R:R:L267	R:R:N218	6.87	No	No	0	9	9
173	R:R:N218	R:R:T271	11.7	No	Yes	0	9	8
174	R:R:A221	R:R:L264	3.15	No	No	0	9	7
175	R:R:E260	R:R:L225	3.98	No	Yes	3	9	9
176	R:R:L225	R:R:L264	2.77	Yes	No	0	9	7
177	R:R:R230	R:R:Y226	11.32	No	No	0	5	5
178	R:R:H229	R:R:R230	10.16	No	No	12	6	5
179	R:R:H229	R:R:Q233	2.47	No	No	12	6	3
180	R:R:Q233	R:R:R230	3.5	No	No	12	3	5
181	R:R:F339	R:R:L258	3.65	No	No	0	5	6
182	R:R:L261	R:R:L265	2.77	No	No	0	5	6
183	R:R:D262	R:R:F326	4.78	No	Yes	0	9	5
184	R:R:D262	R:R:R332	11.91	No	No	0	9	6
185	R:R:F326	R:R:L265	2.44	Yes	No	13	5	6
186	R:R:F335	R:R:L265	2.44	No	No	13	4	6
187	R:R:L266	R:R:L269	4.15	No	No	0	8	5
188	R:R:I322	R:R:L269	4.28	No	No	0	8	5
189	R:R:F326	R:R:L269	2.44	Yes	No	0	5	5
190	R:R:M270	R:R:N319	4.21	No	Yes	0	9	9
191	R:R:L273	R:R:V318	4.47	No	No	0	8	8
192	R:R:F274	R:R:I315	3.77	Yes	No	0	9	9
193	R:R:F274	R:R:N319	4.83	Yes	Yes	0	9	9
194	R:R:M276	R:R:T275	3.01	No	No	0	5	5
195	R:R:C277	R:R:V314	3.42	No	No	0	9	4
196	R:R:C277	R:R:I315	3.27	No	No	0	9	9
197	R:R:F311	R:R:P280	7.22	No	No	0	6	9
198	R:R:E301	R:R:R284	6.98	No	No	1	3	5
199	R:R:E304	R:R:R284	26.75	No	No	0	1	5
200	R:R:D305	R:R:R284	10.72	Yes	No	1	7	5
201	R:R:K291	R:R:Y287	7.17	No	Yes	0	3	4
202	R:R:A289	R:R:F290	4.16	No	No	0	7	3
203	R:R:D292	R:R:V293	4.38	No	No	11	2	1
204	R:R:E295	R:R:K294	5.4	No	No	0	1	1
205	R:R:E295	R:R:S300	12.94	No	No	0	1	1
206	R:R:K296	R:R:T299	3	No	No	0	1	1
207	R:R:D305	R:R:E301	2.6	Yes	No	1	7	3
208	R:R:R310	R:R:S313	2.64	No	No	0	9	9
209	R:R:N319	R:R:P320	3.26	Yes	No	0	9	9
210	R:R:F323	R:R:R327	7.48	No	Yes	0	9	9
211	R:R:F331	R:R:I325	3.77	No	No	0	7	8
212	R:R:F326	R:R:F335	6.43	Yes	No	13	5	4
213	R:R:R327	R:R:R332	3.2	Yes	No	0	9	6
214	R:R:F331	R:R:S328	2.64	No	No	0	7	7
215	R:R:F331	R:R:F334	8.57	No	No	0	7	4
216	R:R:F334	R:R:I338	7.54	No	No	0	4	4
217	R:R:H336	R:R:I340	9.28	No	No	0	4	6
218	R:R:P342	R:R:R341	2.88	No	No	0	4	7
219	R:R:M187	R:R:Y6	2.39	No	Yes	1	7	6
220	R:R:M187	R:R:Y177	2.39	No	Yes	1	7	9
221	R:R:F168	R:R:Q106	2.34	No	No	0	4	4
222	R:R:L32	R:R:W321	2.28	No	No	0	4	8
223	R:R:F311	R:R:R307	2.14	No	No	0	6	4
224	R:R:F335	R:R:F339	2.14	No	No	0	4	5
225	R:R:G23	R:R:G24	2.11	No	No	0	8	4
226	R:R:R223	R:R:Y226	2.06	No	No	0	4	5
227	R:R:C66	R:R:G67	1.96	No	No	0	6	6
228	R:R:A97	R:R:P98	1.87	No	No	0	1	5
229	R:R:A153	R:R:P154	1.87	No	No	0	7	4
230	R:R:G180	R:R:V14	1.84	No	No	0	6	4
231	R:R:G149	R:R:V152	1.84	No	No	0	7	5
232	R:R:G30	R:R:T29	1.82	No	No	0	9	6
233	R:R:A127	R:R:C217	1.81	No	No	0	9	7
234	R:R:P179	R:R:S19	1.78	No	No	0	8	6
235	R:R:P329	R:R:S328	1.78	No	No	0	7	7
236	R:R:G45	R:R:L46	1.71	No	No	0	6	4
237	R:R:G75	R:R:L74	1.71	No	No	0	9	4
238	R:R:A285	R:R:S200	1.71	No	No	0	7	7
239	R:R:G17	R:R:N18	1.7	No	No	0	3	3
240	R:R:A289	R:R:V201	1.7	No	No	0	7	4
241	R:R:A308	R:R:V281	1.7	No	No	0	7	8
242	R:R:C8	R:R:T11	1.69	No	No	0	9	4
243	R:R:A37	R:R:T69	1.68	No	No	0	9	8
244	R:R:A303	R:R:T299	1.68	No	No	0	1	1
245	R:R:L279	R:R:P280	1.64	No	No	0	7	9
246	R:R:S118	R:R:S157	1.63	Yes	No	0	7	6
247	R:R:S193	R:R:S195	1.63	No	No	0	3	1
248	R:R:S28	R:R:V25	1.62	No	No	0	4	4
249	R:R:S328	R:R:V330	1.62	No	No	0	7	7
250	R:R:A150	R:R:M63	1.61	No	No	0	5	6
251	R:R:A285	R:R:M187	1.61	No	No	0	7	7
252	R:R:A268	R:R:M222	1.61	No	No	0	6	7
253	R:R:S92	R:R:T12	1.6	No	No	0	5	5
254	R:R:V314	R:R:V318	1.6	No	No	0	4	8
255	R:R:C217	R:R:L128	1.59	No	No	0	7	7
256	R:R:G135	R:R:H136	1.59	No	No	0	7	4
257	R:R:T271	R:R:V215	1.59	Yes	No	0	8	6
258	R:R:A99	R:R:L100	1.58	No	No	0	5	4
259	R:R:A213	R:R:L124	1.58	No	No	0	6	5
260	R:R:A289	R:R:L197	1.58	No	No	0	7	4
261	R:R:E15	R:R:P179	1.57	No	No	0	3	8
262	R:R:T271	R:R:T275	1.57	Yes	No	0	8	5
263	R:R:A268	R:R:N218	1.56	No	No	0	6	9
264	R:R:I282	R:R:S278	1.55	No	No	0	8	9
265	R:R:H136	R:R:P137	1.53	No	No	0	4	9
266	R:R:K296	R:R:S300	1.53	No	No	0	1	1
267	R:R:M63	R:R:V60	1.52	No	No	0	6	7
268	R:R:A88	R:R:Q89	1.52	No	No	0	5	5
269	R:R:A153	R:R:Q122	1.52	No	Yes	0	7	7
270	R:R:M276	R:R:V272	1.52	No	No	0	5	5
271	R:R:L26	R:R:V25	1.49	No	No	0	8	4
272	R:R:L38	R:R:V70	1.49	No	No	0	7	5
273	R:R:L64	R:R:V60	1.49	No	No	0	8	7
274	R:R:L64	R:R:V152	1.49	No	No	0	8	5
275	R:R:L104	R:R:V82	1.49	No	No	0	5	6
276	R:R:L151	R:R:V155	1.49	No	No	0	3	3
277	R:R:L219	R:R:V215	1.49	No	No	0	5	6
278	R:R:L312	R:R:V281	1.49	No	No	0	8	8
279	R:R:L148	R:R:T145	1.47	No	No	0	5	6
280	R:R:G288	R:R:Y287	1.45	No	Yes	0	7	4
281	R:R:K2	R:R:M1	1.44	No	No	0	5	7
282	R:R:E15	R:R:S13	1.44	No	No	0	3	1
283	R:R:E191	R:R:V188	1.43	No	No	0	1	3
284	R:R:L26	R:R:M22	1.41	No	No	0	8	3
285	R:R:L146	R:R:M63	1.41	No	No	0	4	6
286	R:R:L312	R:R:M112	1.41	No	No	0	8	8
287	R:R:L134	R:R:M228	1.41	No	No	3	8	8
288	R:R:L225	R:R:M228	1.41	Yes	No	3	9	8
289	R:R:A165	R:R:F110	1.39	No	Yes	0	5	7
290	R:R:L31	R:R:L73	1.38	No	Yes	2	6	8
291	R:R:L35	R:R:L73	1.38	No	Yes	2	5	8
292	R:R:L38	R:R:L73	1.38	No	Yes	0	7	8
293	R:R:L100	R:R:L104	1.38	No	No	0	4	5
294	R:R:D101	R:R:N102	1.35	No	No	0	4	1
295	R:R:R147	R:R:T145	1.29	No	No	0	4	6
296	R:R:H189	R:R:L197	1.29	No	No	0	4	4
297	R:R:S59	R:R:Y62	1.27	No	No	0	7	7
298	R:R:M228	R:R:R231	1.24	No	No	0	8	5
299	R:R:K294	R:R:Y287	1.19	No	Yes	0	1	4
300	R:R:F110	R:R:F168	1.07	Yes	No	0	7	4
301	R:R:F168	R:R:F174	1.07	No	Yes	0	4	6
302	R:R:R307	R:R:R310	1.07	No	No	0	4	9
303	R:R:Y283	R:R:Y287	0.99	No	Yes	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F5	6.23667	6	1	4
2	R:R:Y6	6.02	7	1	6
3	R:R:N34	7.735	4	2	9
4	R:R:F61	5.194	5	6	9
5	R:R:L73	3.78	4	2	8
6	R:R:K76	4.482	5	2	8
7	R:R:L79	3.435	4	8	6
8	R:R:R94	5.8225	4	0	2
9	R:R:F108	3.098	5	0	6
10	R:R:F110	2.61	5	0	7
11	R:R:F114	6.31	4	0	7
12	R:R:S118	2.7525	4	7	7
13	R:R:Q122	4.778	5	7	7
14	R:R:F171	4.3225	4	0	4
15	R:R:F174	5.805	4	0	6
16	R:R:V175	6.3625	4	1	4
17	R:R:Y177	5.648	5	1	9
18	R:R:W182	4.735	4	0	9
19	R:R:I185	5.1125	4	0	7
20	R:R:Q186	9.4175	4	1	5
21	R:R:Y199	6.05	4	0	6
22	R:R:L225	3.77	4	3	9
23	R:R:T271	4.504	5	0	8
24	R:R:F274	5.022	5	0	9
25	R:R:Y287	2.7	4	0	4
26	R:R:D305	6.4925	4	1	7
27	R:R:N319	3.7625	4	0	9
28	R:R:F326	4.0225	4	13	5
29	R:R:R327	5.734	5	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F174	R:R:I185	71.061	3.77	Yes	Yes	0	6	7
2	R:R:F184	R:R:I185	62.2035	7.54	No	Yes	0	8	7
3	R:R:F184	R:R:Y177	53.5966	7.22	No	Yes	0	8	9
4	R:R:Y177	R:R:Y6	31.3153	7.94	Yes	Yes	1	9	6
5	R:R:F5	R:R:Y6	17.9397	10.32	Yes	Yes	1	4	6
6	R:R:V175	R:R:Y177	10.9652	3.79	Yes	Yes	1	4	9
7	R:R:G30	R:R:T29	11.0755	1.82	No	No	0	9	6
8	R:R:G30	R:R:K76	11.7011	5.23	No	Yes	2	9	8
9	R:R:K76	R:R:N34	13.6503	6.99	Yes	Yes	2	8	9
10	R:R:N34	R:R:P320	20.6128	4.89	Yes	No	0	9	9
11	R:R:N319	R:R:P320	21.2144	3.26	Yes	No	0	9	9
12	R:R:L68	R:R:N319	56.2075	2.75	No	Yes	0	9	9
13	R:R:L68	R:R:Q122	56.4281	6.65	No	Yes	0	9	7
14	R:R:Q122	R:R:S118	56.8532	2.89	Yes	Yes	7	7	7
15	R:R:S118	R:R:S160	58.5778	3.26	Yes	No	0	7	7
16	R:R:F114	R:R:S160	100	7.93	Yes	No	0	7	7
17	R:R:F114	R:R:F115	18.8241	9.65	Yes	No	0	7	8
18	R:R:F115	R:R:L79	17.5928	2.44	No	Yes	0	8	6
19	R:R:F108	R:R:L79	16.4237	2.44	Yes	Yes	0	6	6
20	R:R:C183	R:R:F108	11.3301	4.19	No	Yes	0	9	6
21	R:R:R327	R:R:R332	13.3455	3.2	Yes	No	0	9	6
22	R:R:D262	R:R:R332	14.4605	11.91	No	No	0	9	6
23	R:R:D262	R:R:F326	15.4972	4.78	No	Yes	0	9	5
24	R:R:F326	R:R:L269	21.8341	2.44	Yes	No	0	5	5
25	R:R:L266	R:R:L269	23.9798	4.15	No	No	0	8	5
26	R:R:F61	R:R:L266	25.0546	4.87	Yes	No	0	9	8
27	R:R:F61	R:R:M126	63.523	3.73	Yes	No	6	9	9
28	R:R:L267	R:R:M126	65.4762	4.24	No	No	0	9	9
29	R:R:L267	R:R:N218	69.0858	6.87	No	No	0	9	9
30	R:R:N218	R:R:T271	71.7509	11.7	No	Yes	0	9	8
31	R:R:L123	R:R:T271	80.3738	2.95	No	Yes	0	8	8
32	R:R:F274	R:R:L123	81.214	7.31	Yes	No	0	9	8
33	R:R:F274	R:R:T120	41.0733	2.59	Yes	No	0	9	7
34	R:R:L210	R:R:T120	41.2878	5.9	No	No	0	6	7
35	R:R:L206	R:R:L210	40.8306	2.77	No	No	0	5	6
36	R:R:L117	R:R:L206	40.5078	2.77	No	No	10	8	5
37	R:R:L117	R:R:S160	41.6969	3	No	No	0	8	7
38	R:R:F274	R:R:N319	47.0271	4.83	Yes	Yes	0	9	9
39	R:R:R130	R:R:S133	21.3448	3.95	No	No	0	9	9
40	R:R:A263	R:R:R130	38.0051	4.15	No	No	0	8	9
41	R:R:A263	R:R:F61	38.9576	4.16	No	Yes	0	8	9
42	R:R:F168	R:R:F174	79.333	1.07	No	Yes	0	4	6
43	R:R:F110	R:R:F168	81.6131	1.07	Yes	No	0	7	4
44	R:R:F110	R:R:L161	41.5104	2.44	Yes	No	0	7	3
45	R:R:F114	R:R:L161	41.7691	4.87	Yes	No	0	7	3
46	R:R:C164	R:R:F110	41.5104	2.79	No	Yes	0	8	7
47	R:R:C164	R:R:F114	41.7691	2.79	No	Yes	0	8	7
48	R:R:S133	R:R:Y140	11.3081	11.45	No	No	5	9	8
49	R:R:E260	R:R:R130	16.7666	8.14	No	No	0	9	9
50	R:R:E260	R:R:L225	12.3328	3.98	No	Yes	3	9	9
51	R:R:I144	R:R:Y140	10.3395	4.84	No	No	0	5	8
52	R:R:F174	R:R:P167	12.6918	8.67	Yes	No	0	6	9
53	R:R:Q186	R:R:V196	13.3275	2.87	Yes	No	0	5	5
54	R:R:H189	R:R:V196	11.1256	5.54	No	No	0	4	5
55	R:R:A289	R:R:L197	10.0928	1.58	No	No	0	7	4
56	R:R:H189	R:R:L197	13.4498	1.29	No	No	0	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9EI5

PDB Summary
PDB	9EI5
Class	A
SubFamily	Lipid
Type	Prostanoid
SubType	DP1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.84
Date	2025-09-03
D.O.I.	doi.org/10.1038/s41467-025-64002-z

Net Summary
I_min	2.44
Number of Linked Nodes	282
Number of Links	303
Number of Hubs	29
Number of Links mediated by Hubs	115
Number of Communities	13
Number of Nodes involved in Communities	58
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	67908
Length Of Smallest Path	3
Average Path Length	20.1727
Length of Longest Path	37
Minimum Path Strength	1.07
Average Path Strength	4.69675
Maximum Path Strength	14.79
Minimum Path Correlation	0.7
Average Path Correlation	0.925366
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	38.0747
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.6958
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13258
Sequence	>9EI5_Chain_R M K S P F Y R C Q N T T S V E K G N S A V M G G V L F S T G L L G N L L A L G L L A R S G L S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N R S L R V L A P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E W L S L G H P F F Y R R H I T L R L G A L V A P V V S A F S L A F C A L P F M G F G K F V Q Y C P G T W C F I Q M V H E E G S L S V L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q L E E L D L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K D V K E K N R T S E E A E D L R A L R F L S V I S I V P W I F I I F R S P V F R I F F H K I F I R P R A N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9E9S	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ1	2.68	2025-09-03	To be published
	9E9S (No Gprot)	A	Lipid	Prostanoid	DP₁	Homo sapiens	PGD2	-		2.68	2025-09-03	To be published
	9EE5	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-2550289	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9EKH	A	Lipid	Prostanoid	DP₁	Homo sapiens	ONO-3030297	-	-	2.89	2025-09-03	doi.org/10.1038/s41467-025-64002-z
	9UWD	A	Lipid	Prostaglandin	DP₁	Homo sapiens	-	-	-	-	2025-04-09	doi.org/10.1073/pnas.2501902122
	8ZVZ	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZVZ (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.35	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	9AU0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-	Gs/β1/γ2	2.45	2025-08-27	To be published
	9AU0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	BW245C	-		2.45	2025-08-27	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9EI5.zip

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