Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x35 5.76687405
21x42 3.3675407
31x50 5.96562409
41x56 1.8775408
52x42 5.37375608
62x46 4.148134159
72x50 4.998754159
82x51 3.40687408
9E1x50 5.89833628
10E1x52 5.2435506
113x50 6.624384169
12I2x56 5.62505
13I2x57 8.38812407
144x61 7.841527
15E2 13.31981323
16E2x52 7.63063425
175x37 3.93437404
185x39 6.614527
195x47 4.362508
205x58 7.02188409
215x66 1.96625406
226x48 6.46875628
23E3 8.82812823
247x42 6.395507
257x53 5.25055169
26b.1x3 2.48438401
27b.1x4 2.01437408
28b.1x5 1.48937403
29b.1x11 2.1225408
30b.b1x6 7.08437439
31b.l1x3 9.176539
32b.l1x6 10.3125419
33b.b2x1 7.56518
34b.b2x5 6.05375637
35b.b3x3 4.68563488
36b.l3x2 4.4095509
37b.b4x2 4.65938408
38b.b4x3 4.47062407
39b.b4x5 5.113587
40b.b4x6 8.9475739
41b.l4x2 9.73875434
42b.b5x2 4.68875607
43b.b5x3 6.13583639
44b.b5x5 5.81125485
45b.b5x7 5.98688407
46b.l5x1 4.41563408
47b.l5x5 5.97906819
48b.b6x5 4.51187886
49b.l6x5 5.828754124
50b.b7x1 5.620624124
51b.l7x2 5.4875419
52b.b8x4 6.03506
53b.l8x3 3.46062403
54b.b9x3 6.29187406
55b.l9x3 7.63417619
56b.l9x6 5.47107718
57b.b10x3 3.62125408
58b.b10x5 4.253509
59b.l10x1 4.31125403
60b.b11x2 4.175407
61b.b11x4 5.39437419
62b.b11x6 7.63419
63b.l11x2 8.76813419
64b.b12x6 8.50286718
65b.b13x7 8.172567
66b.l13x3 7.815569
67b.l13x6 4.79562419
68b.b14x3 5.15438465
69b.b15x1 8.0625469
70b.b15x2 7.05563456
71b.l15x1 4.7065517
72b.b16x4 10.6838466
73b.b16x6 7.81607768
74b.b16x7 7.86254189
75b.l17x3 7.30417659
76b.l17x6 6.762519
77b.b18x3 5.25063458
78b.b18x5 4.4395555
79b.l18x1 6.053937136
80b.b19x2 7.35917656
81b.b19x4 6.57312458
82b.l19x1 6.87062419
83b.l19x2 5.825559
84b.b20x4 7.563558
85b.b20x6 7.7475556
86b.b21x7 5.86542605
87b.l21x2 6.9175404
88b.b22x5 4.032507
89b.l22x5 7.0275119
90b.b23x6 6.62255197
91b.b24x7 7.601884119
92b.l25x3 8.0445579
93b.b27x3 5.63408
94b.l27x1 10.9607719
95b.l27x2 6.39937479
96b.b28x4 6.76313476
97b.b28x6 9.536579
98g.l1x4 5.13875408
99g.h2x11 10.33694136
100g.ctx3 5.67417609
101g.ctx6 3.92438406
102g.ctx14 4.374509
103g.ctx16 4.24857738
104G.S1.01 5.74937406
105G.H1.04 6.4675447
106G.H1.08 4.35188409
107G.H1.11 2.58313408
108G.S2.04 7.87875407
109G.S2.06 3.87813408
110G.S3.01 3.59188494
111G.S3.03 4.22708697
112G.s3h2.03 4.71813419
113G.H2.06 6.47833619
114G.H2.07 5.23656819
115G.h2s4.01 6.792519
116G.s4h3.03 5.33754147
117G.s4h3.04 4.7595228
118G.s4h3.05 6.93055229
119G.H3.06 4.2865507
120G.H3.09 5.4985509
121G.H3.17 6.77375405
122G.S5.05 5.035549
123G.s5hg.01 3.348549
124G.hgh4.02 3.9254108
125G.hgh4.05 4.686506
126G.H4.10 4.51855107
127G.H4.15 4.366254109
128G.h4s6.08 5.833134237
129G.h4s6.13 4.214237
130G.S6.02 7.5795218
131G.s6h5.01 5.99563449
132G.H5.04 3.00312407
133G.H5.08 3.4025598
134G.H5.22 2.8425404
135G.H5.23 5.971504
136Lig 13.19871820
137I3 2.73222940
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x36 Lig 14.964810.725NoYes270
23x36 6x48 15.15426.435NoYes278
36x48 6x52 22.97586.5875YesNo087
45x461 6x52 26.7115.0275NoNo087
53x37 5x461 26.8923.375NoNo088
63x37 4x53 27.43365.2975NoNo088
73x38 4x53 28.33174.04NoNo088
83x38 4x50 28.689419.31NoNo089
92x45 4x50 28.86784.945NoNo099
102x45 4x46 29.04617.74NoNo097
112x42 4x46 29.22416.28YesNo087
122x42 3x46 15.99763.77YesNo089
132x42 3x49 42.97519.3275YesNo089
143x49 I2x57 43.31356.69NoYes097
15G.H5.23 I2x57 44.92969.865YesYes047
162x39 G.H5.23 84.19163.7475NoYes084
172x37 2x39 84.26933.14NoNo078
182x37 2x40 84.34679.87NoNo079
192x40 I1x50 84.65423.7975NoNo098
201x60 I1x50 84.73055.1825NoNo068
211x60 I1x51 84.80653.9525NoNo068
22I1x48 I1x51 85.03343.0575NoNo078
23I1x48 b.l25x4 85.10525.3975NoNo075
243x53 G.H5.23 57.21437.3375NoYes084
253x53 G.H5.19 57.07874.3NoNo088
26G.H5.15 G.H5.19 56.94293.5425NoNo088
27G.H5.15 I2x51 56.28673.5675NoNo087
28G.S3.01 I2x51 28.07515.215YesNo947
29G.S3.01 G.S3.03 27.76384.2575YesYes947
30G.S2.08 G.S3.03 43.28683.9575NoYes057
31G.H5.04 G.S2.08 42.6144.2825YesNo075
32G.H1.08 G.H5.04 40.25413.6425YesYes097
33G.H1.04 G.H1.08 17.27226.2175YesYes079
34G.S5.05 G.S6.04 11.3014.525YesNo499
35G.H5.06 G.S6.04 15.868622.3425NoNo449
36G.H5.06 I3 14.80422.1975NoYes440
37G.H5.08 I2x51 28.07483.35YesNo987
38G.H5.08 G.S3.03 27.81853.7525YesYes987
39G.H1.08 G.H5.03 17.2533.5025YesNo098
40b.l25x4 b.l27x2 85.47865.655NoYes059
41b.l25x3 b.l27x2 85.49475.6725YesYes799
42b.b27x3 b.l25x3 85.78646.8475YesYes089
43b.b26x3 b.b27x3 86.90453.685NoYes068
44b.b23x3 b.b26x3 87.04077.265NoNo076
45b.b23x3 b.b27x1 87.10845.215NoNo076
46b.b27x1 g.ctx5 87.31033.3525NoNo069
47g.ctx3 g.ctx5 87.37713.395YesNo099
48g.ctx3 g.ctx4 92.27133.6225YesNo097
49b.l26x5 g.ctx4 92.31835.0325NoNo057
50b.l26x3 b.l26x5 87.95474.16NoNo075
51b.l26x1 b.l26x3 87.90847.23NoNo377
52b.b2x5 b.l26x1 88.076510.9175YesNo377
53b.b2x5 b.b3x2 88.79959.965YesNo075
54b.b3x2 b.b4x6 88.83695.9775NoYes059
55b.b4x6 b.l1x3 93.4244.495YesYes399
56b.b3x6 b.l1x3 95.883311.5075NoYes099
57b.b3x6 b.l3x2 95.91176.625NoYes099
58b.b4x2 b.l3x2 96.0236.225YesYes089
59b.b4x2 b.b5x8 96.13063.3425YesNo085
60b.b5x7 b.b5x8 96.1573.39YesNo075
61b.b4x3 b.b5x7 95.23136.065YesYes077
62b.b3x3 b.b4x3 97.91893.3525YesYes087
63b.b3x3 b.b6x5 97.78986.94YesYes886
64b.b2x4 b.b6x5 98.58313.5425NoYes066
65b.b10x4 b.b2x4 98.597213.54NoNo066
66b.b10x2 b.b10x4 98.62776.265NoNo066
67b.b10x2 b.b6x2 1002.9575NoNo068
68b.b10x3 b.b6x2 99.99814.6475YesNo088
69b.b10x3 b.b11x4 96.86023.38YesYes089
70b.b11x4 b.l9x3 49.49325.48YesYes199
71b.b10x2 b.b14x3 10.70724.7575NoYes065
72b.b11x6 b.l9x3 48.174214.2975YesYes199
73b.b11x6 b.l11x1 95.87453.2475YesNo199
74b.l11x1 b.l9x6 67.79786.1575NoYes198
75G.H2.06 b.l9x6 30.45984.1775YesYes198
76G.H2.06 b.l17x6 29.492311.06YesYes199
77b.l17x5 b.l17x6 56.15752.9425NoYes069
78b.l17x5 b.l19x2 55.70293.31NoYes069
79b.l17x3 b.l19x2 39.80263.465YesYes599
80b.b19x4 b.l17x3 24.36037.87YesYes589
81b.b19x4 b.b20x6 11.73237.7825YesYes586
82b.b17x7 b.b20x6 23.924510.4475NoYes586
83b.b17x5 b.b17x7 22.55738.785NoNo078
84b.b17x5 b.b21x1 21.14928.485NoNo077
85b.b21x1 g.l1x4 12.695611.315NoYes078
86b.b11x4 b.l9x7 46.71373.3175YesNo197
87b.b11x6 b.l9x7 46.65334.88YesNo197
88b.l11x1 b.l13x6 27.90234.1925NoYes199
89b.l13x6 b.l15x1 27.26765.055YesYes197
90b.l15x1 b.l17x6 27.07955.445YesYes179
91b.b20x4 b.l17x3 13.599612.1275YesYes589
92b.b20x4 b.b20x6 23.45274.545YesYes586
93b.b20x2 b.l19x2 14.52539.035NoYes069
94b.b20x2 b.b20x4 13.59854.525NoYes068
95b.l22x2 g.ctx3 12.42483.4575NoYes019
96b.l22x2 g.ctx2 12.03093.0375NoNo013
97g.ctx2 g.h2x15 11.6364.615NoNo036
98g.h2x11 g.h2x15 11.240314.7YesNo066
99G.H2.07 b.l9x6 40.72143.615YesYes198
100b.l3x1 b.l5x5 11.70925.475NoYes199
101b.b2x1 b.l3x1 10.693410.99YesNo189
102b.b18x3 b.b19x4 12.18014.18YesYes588
103G.H2.04 G.H2.07 20.06275NoYes099
104G.H2.04 G.H3.08 19.82243.9475NoNo099
105G.H3.08 G.S4.04 19.35196.7NoNo2099
106G.H3.09 G.S4.04 19.471811.255YesNo099
107G.H3.09 G.h4s6.01 14.72923.3475YesNo093
108G.H3.06 G.h4s6.01 14.483.525YesNo073
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x326.8850NoNo7821
2x567x427.39250NoYes7722
2x63E1x506.142NoYes5811
2x63Lig4.79752NoYes5010
E1x49E24.76250NoYes4321
E1x50E1x528.30752YesYes8612
3x25E1x505.242NoYes9821
E1x50E2x508.032YesNo8912
E1x50Lig4.32YesYes8010
3x22E23.9252NoYes4321
3x25E2x507.282NoNo9922
3x283x324.170NoNo6821
3x294x613.80NoYes5721
3x294x657.5950NoNo5622
3x32Lig7.932NoYes8010
3x366x486.4352NoYes7812
3x36Lig10.7252NoYes7010
4x574x614.190NoYes8721
4x61E2x529.11252YesYes7511
4x615x397.2352YesYes7712
4x61Lig14.86752YesYes7010
4x64E216.15252NoYes4321
4x65E2x525.1350NoYes6521
E2E246.8752YesYes3311
E2E2x504.63752YesNo3912
E2E2x516.49252YesNo3411
E2Lig15.242YesYes3010
E2x51Lig6.122NoYes4010
E2E2x525.162YesYes3511
E2x52Lig11.1152YesYes5010
5x36E27.082NoYes5321
5x39E25.492YesYes7321
5x35E27.0952NoYes4321
6x55Lig13.730NoYes7010
6x57E314.40752NoYes5321
6x58E37.68752NoYes4311
6x58Lig19.482NoYes4010
6x62E34.23750NoYes1321
E3Lig24.36252YesYes3010
E3E36.95752YesYes3311
7x33E33.69252NoYes5321
7x347x373.68252NoNo4612
7x347x384.0252NoNo4511
7x34Lig20.25752NoYes4010
7x387x428.06252NoYes5712
7x38Lig3.742NoYes5010
E1x50E23.37252YesYes8311
2x64Lig2.67750NoYes5010
2x67Lig2.49250NoYes4010
7x31E32.32250NoYes3321
2x622x632.07750NoNo5521
6x54Lig1.62250NoYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
73.68Single7F8XNN90567F8X-CCKA-NN9056
72.22Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
72.22Consensuscck_onOrthosteric Ligandccka_on cckb_on
72.22Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
70.59Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
70.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
68.42Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
65.22Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
63.16Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
63.16Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
63.16Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
61.90Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
61.90Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
60.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
59.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
57.14Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
56.52Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
54.55Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
53.85Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
52.38Single7XN9L-054,5227XN9-SST2-L-054,522
52.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
52.17Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
52.17Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
52.17Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
52.17Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
52.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
52.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
51.85Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
51.85Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
51.85Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
51.72Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
50.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
50.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
50.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
50.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
48.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
47.62Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.62Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
47.62Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.37Single5N2SPSB365N2S-A1-PSB36
46.15Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
45.83Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.83Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
45.83Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.83Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
45.83Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
45.45Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
45.45Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
45.45Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
45.45Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.45Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
45.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
44.44Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
44.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
43.48Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
43.48Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
43.48Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
43.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
42.86Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
42.86Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
42.86Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
42.86Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.31Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.31Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.31Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
42.31Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
42.31Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
42.31Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
42.31Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Single3QAKUK-4320973QAK-A2A-UK-432097
41.67Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
41.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
41.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
41.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
40.91Single7EZCUKA7EZC-A2A-UKA
40.91Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
40.91Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.74Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
40.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
40.00Single5WF5UK-4320975WF5-A2A-UK-432097
40.00Single6PT2KGCHM076PT2-δ-KGCHM07
40.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
40.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
40.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
40.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
40.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
39.29Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
39.29Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
39.29Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
39.29Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
39.29Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
39.13Single4UG2CGS216804UG2-A2A-CGS21680
39.13Single5WF6UK-4320975WF6-A2A-UK-432097
39.13Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
39.13Single8QJ2pN1628QJ2-MC4-pN162-Gs
39.13Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
39.13Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
38.89Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
38.89Single7F8ULintitript7F8U-CCKA-Lintitript
38.89Single7F8YDevazepide7F8Y-CCKA-Devazepide
38.89Single8GNGIstradefylline8GNG-A2A-Istradefylline
38.46Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
38.46Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
38.46Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.46Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
38.46Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
38.46Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
38.10Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
38.10Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
38.10Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
38.10Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
38.10Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
37.93Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
37.93Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
37.50Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
37.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
37.50Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.04Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.04Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
37.04Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
37.04Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single8ZRTET-18ZRT-ETB-ET-1
37.04Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
37.04Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.04Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.04Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
36.84Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
36.84Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
36.84Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
36.84Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
36.84Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
36.84Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
36.84Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
36.84Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
36.84Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
36.84Consensushca_onOrthosteric Ligandhca2_on
36.67Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.67Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.67Consensusbombesin_onOrthosteric Ligandbb2_on
36.67Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
36.67Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.36Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
36.36Single6MXTSalmeterol6MXT-β2-Salmeterol
36.36Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
36.36Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.36Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
36.36Single8JJLOlodaterol8JJL-β2-Olodaterol
36.36Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
36.36Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
36.36Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
36.36Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
36.00Single7SK5CXCL127SK5-ACKR3-CXCL12
36.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
36.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
36.00Single7XNACYN1548067XNA-SST2-CYN154806
36.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
36.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
36.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
36.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
36.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
36.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
36.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
35.71Single7SK3CXCL127SK3-ACKR3-CXCL12
35.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
35.29Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
35.00Single5UENDU1725UEN-A1-DU172
35.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
35.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
35.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.00Single8CU6LJ-45178CU6-A2A-LJ-4517
35.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
35.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
35.00Single8K5DGSK2560738K5D-HCA2-GSK256073
35.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
35.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
35.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
35.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
35.00Consensusa3_onOrthosteric Liganda3a_on
35.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
35.00Consensuscck_offOrthosteric Ligandccka_off
35.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
35.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
35.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
35.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
35.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
35.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
35.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
34.78Single4BUONeurotensin4BUO-NTS1-Neurotensin
34.78Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.78Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
34.78Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
34.78Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
34.78Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
34.62Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
34.62Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
34.62Consensusangiotensin_onOrthosteric Ligandat1_on
34.62Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
34.62Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
34.62Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
33.33Single3OE9IT1t3OE9-CXCR4-IT1t
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
33.33Single6IGLIRL16206IGL-ETB-IRL1620
33.33Single6JODAngiotensin II6JOD-AT2-Angiotensin II
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
33.33Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
33.33Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
33.33Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
33.33Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
33.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
33.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
33.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
33.33Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
33.33Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
33.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
33.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
33.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
33.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
32.26Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.26Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.14Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
32.14Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
32.14Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
32.14Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
32.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
32.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
32.00Single4XT1Fractalkine4XT1-US28-Fractalkine
32.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
32.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
32.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
32.00Single8WDTphotoNECA8WDT-A2A-photoNECA
32.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
32.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
32.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
32.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
32.00Consensussomatostatin_offOrthosteric Ligandsst2_off
31.82Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
31.82Single4BV0Neurotensin4BV0-NTS1-Neurotensin
31.82Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
31.82Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.82Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
31.82Single7PX4PSB-21137PX4-A2A-PSB-2113
31.82Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
31.82Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
31.82Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
31.82Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.82Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
31.82Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
31.82Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
31.82Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.82Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
31.82Consensusa2_onOrthosteric Liganda2b_on
31.82Consensusa2_on_gpOrthosteric Liganda2b_on_gp
31.82Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.82Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.82Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
31.82Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.82Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
31.82Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single3PWHZM-2413853PWH-A2A-ZM-241385
31.58Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
31.58Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
31.58Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
31.58Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
31.58Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
31.58Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
31.58Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
31.58Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
31.58Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
31.58Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
31.58Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
31.58Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
31.58Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
31.58Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
31.43Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.25Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
31.25Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.25Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
31.25Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
31.03Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
31.03Single6FJ3PTH6FJ3-PTH1-PTH
31.03Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
31.03Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.03Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
31.03Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
31.03Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.03Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
31.03Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
30.77Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
30.77Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.77Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
30.77Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.77Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
30.43Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
30.43Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.43Single4XEENeurotensin4XEE-NTS1-Neurotensin
30.43Single4XESNeurotensin4XES-NTS1-Neurotensin
30.43Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.43Single6OS2TRV0266OS2-AT1-TRV026
30.43Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
30.43Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
30.43Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.43Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.43Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
30.43Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.43Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
30.43Single8JWY2-1188JWY-A2A-2-118
30.43Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
30.43Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.43Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.43Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
30.43Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.43Consensusorexin_onOrthosteric Ligandox2_on
30.00Single2YDOAdenosine2YDO-A2A-Adenosine
30.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
30.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
30.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
30.00Single5JTBZM-2413855JTB-A2A-ZM-241385
30.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
30.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
30.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
30.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
30.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.00Single6V9SGTPL114036V9S-OX1-GTPL11403
30.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
30.00Single7AROLUF58337ARO-A2A-LUF5833-Na
30.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
30.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
30.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
30.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
30.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
30.00Single8IHKAcifran8IHK-HCA3-Acifran
30.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
30.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
30.00Single8K5CAcipimox8K5C-HCA2-Acipimox
30.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
30.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
30.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
30.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
30.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
30.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
30.00Consensusa2_offOrthosteric Liganda2a_off
30.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
30.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
30.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusgrh_offOrthosteric Ligandgnrh1_off
30.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
30.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
29.63Single3OE0CVX153OE0-CXCR4-CVX15
29.63Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
29.63Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
29.63Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
29.63Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
29.63Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.63Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.63Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.41Single8A2OTheophylline8A2O-A2A-Theophylline-Na
29.17Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
29.17Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
29.17Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
29.17Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
29.17Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
29.17Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
29.17Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
29.17Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
29.17Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.17Consensuschemerin_onOrthosteric Ligandcml1_on
29.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
29.17Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
29.17Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.03Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
29.03Single8IY6Endothelin-18IY6-ETB-Endothelin-1
29.03Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.03Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
29.03Consensusbradykinin_onOrthosteric Ligandbk2_on
29.03Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
29.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
29.03Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.03Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Single3EMLZM-2413853EML-A2A-ZM-241385
28.57Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single5IU8Q274563475IU8-A2A-Q27456347-Na
28.57Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
28.57Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
28.57Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
28.57Single5UIGCmpd-15UIG-A2A-Cmpd-1
28.57Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
28.57Single6D27CAY104716D27-DP2-CAY10471
28.57Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
28.57Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
28.57Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
28.57Single6PS1Timolol6PS1-β2-Timolol
28.57Single6S0LZM-2413856S0L-A2A-ZM-241385
28.57Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
28.57Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
28.57Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
28.57Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
28.57Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Single7PYRPSB-21157PYR-A2A-PSB-2115
28.57Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
28.57Single7UL4Alvimopan7UL4-μ-Alvimopan
28.57Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
28.57Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.57Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
28.57Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
28.57Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
28.57Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
28.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single9CHXS-Carazolol9CHX-β2-S-Carazolol
28.57Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
28.57Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.57Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
28.57Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
28.57Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
28.57Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
28.57Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
28.57Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
28.57Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
28.12Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.12Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.12Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
28.00Single3NY9ICI118-5513NY9-β2-ICI118-551
28.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
28.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
28.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
28.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
28.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
28.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
28.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
28.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
28.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
28.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
27.78Single3OE6IT1t3OE6-CXCR4-IT1t
27.78Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
27.78Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
27.78Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
27.78Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
27.59Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
27.59Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
27.59Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
27.59Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
27.59Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
27.59Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
27.59Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
27.59Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.27Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
27.27Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.27Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
27.27Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
27.27Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.27Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
27.27Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
27.27Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.27Single6S0QZM-2413856S0Q-A2A-ZM-241385
27.27Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
27.27Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
27.27Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
27.27Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
27.27Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
27.27Single7W41PD1762527W41-BB2-PD176252
27.27Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
27.27Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
27.27Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
27.27Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
27.27Single8S4DCMF-0198S4D-Apelin-CMF-019
27.27Single8TF5Oleic acid8TF5-GPR6-Oleic acid
27.27Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
27.27Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
27.27Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.27Consensusbombesin_offOrthosteric Ligandbb2_off
27.27Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.27Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.27Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
27.27Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.27Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
27.27Consensusdp_offOrthosteric Liganddp2_off
27.27Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
27.27Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
26.92Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
26.92Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
26.92Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.92Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
26.92Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
26.92Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
26.92Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
26.92Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.92Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
26.92Single8WKYPG-9348WKY-MC4-PG-934
26.92Single8XWNCXCL88XWN-CXCR2-CXCL8
26.92Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.92Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.92Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.92Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
26.92Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.92Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
26.92Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.83Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
26.67Single4XT3Fractalkine4XT3-US28-Fractalkine
26.67Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
26.47Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.32Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
26.32Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
26.32Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.32Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
26.32Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
26.32Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
26.32Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
26.32Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.32Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
26.32Consensusgq_nucleotideOrthosteric Ligandgq_p2y
26.32Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.09Single2YDVNECA2YDV-A2A-NECA
26.09Single3P0GBI1671073P0G-β2-BI167107
26.09Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.09Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.09Single4UHRCGS216804UHR-A2A-CGS21680
26.09Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.09Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.09Single5G53NECA5G53-A2A-NECA-Gs
26.09Single5XR8AM8415XR8-CB1-AM841
26.09Single5XRAAM115425XRA-CB1-AM11542
26.09Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
26.09Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.09Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.09Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.09Single6WGTLSD6WGT-5-HT2A-LSD
26.09Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
26.09Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.09Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
26.09Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
26.09Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.09Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.09Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
26.09Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.09Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
26.09Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
26.09Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.09Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.09Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
26.09Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
26.09Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
26.09Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
26.09Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
26.09Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.09Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.09Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.09Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.09Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.09Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.09Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
26.09Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.09Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.09Consensusneurotensin_onOrthosteric Ligandnts1_on
26.09Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.09Consensusrelaxin_onOrthosteric Ligandrxfp4_on
26.09Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.93Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
25.93Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.93Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.93Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
25.93Single8IEBA1LYA8IEB-GPR156-A1LYA
25.93Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
25.93Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
25.93Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
25.93Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
25.93Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.93Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.93Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.93Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
25.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
25.00Single6TODEMPA6TOD-OX1-EMPA-Na
25.00Single6W25SHU91196W25-MC4-SHU9119-Ca
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
25.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
25.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
25.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
25.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
25.00Single8IWESpermidine8IWE-TA9-Spermidine
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
25.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
25.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
25.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
25.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
25.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
25.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
25.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
25.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.24Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
24.24Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
24.14Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.14Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
24.14Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.14Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
24.14Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
24.14Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.14Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.14Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
24.14Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.14Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.14Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.14Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
24.14Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
24.14Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.14Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.14Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.14Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
24.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
24.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
24.00Single6H7LDobutamine6H7L-β1-Dobutamine
24.00Single6IBLArformoterol6IBL-β1-Arformoterol
24.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
24.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
24.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
24.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
24.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
24.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
24.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
24.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
24.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
24.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
24.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
24.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
24.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single8XVUCXCL28XVU-CXCR2-CXCL2
24.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
24.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
24.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
24.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
23.81Single3REYXAC3REY-A2A-XAC
23.81Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
23.81Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
23.81Single4ZJCSB-6740424ZJC-OX1-SB-674042
23.81Single5UVIZM-2413855UVI-A2A-ZM-241385
23.81Single6AQFZM-2413856AQF-A2A-ZM-241385
23.81Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.81Single6PS0S-Carazolol6PS0-β2-S-Carazolol
23.81Single6PS4ICI118-5516PS4-β2-ICI118-551
23.81Single6PS5S-Propranolol6PS5-β2-S-Propranolol
23.81Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
23.81Single6VI4JDTic6VI4-κ-JDTic
23.81Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.81Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.81Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
23.81Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.81Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single7T32ZM-2413857T32-A2A-ZM-241385
23.81Single7UL3Famotidine7UL3-H2-Famotidine
23.81Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
23.81Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
23.81Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
23.81Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
23.81Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
23.81Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
23.81Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
23.81Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
23.81Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
23.81Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
23.81Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
23.81Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
23.81Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
23.81Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
23.81Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.53Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.53Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
23.53Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
23.53Single8PWNTheophylline8PWN-A2A-Theophylline
23.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
23.33Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
23.33Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
23.33Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
23.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
23.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.08Single5ZTYAM102575ZTY-CB2-AM10257
23.08Single6PT3DPI-2876PT3-δ-DPI-287
23.08Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.08Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
23.08Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.08Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
23.08Single8XQJJN2418XQJ-Apelin-JN241
23.08Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
23.08Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
23.08Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
23.08Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
23.08Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
23.08Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
23.08Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
23.08Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
22.73Single2Y02Carmoterol2Y02-β1-Carmoterol
22.73Single3NY8ICI118-5513NY8-β2-ICI118-551
22.73Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
22.73Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
22.73Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
22.73Single4EJ4Naltrindole4EJ4-δ-Naltrindole
22.73Single4GBRS-Carazolol4GBR-β2-S-Carazolol
22.73Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
22.73Single4QIMANTA XV4QIM-SMO-ANTA XV
22.73Single4QKX35V4QKX-β2-35V
22.73Single4YAYZD-71554YAY-AT1-ZD-7155
22.73Single5DHGC-355DHG-NOP-C-35
22.73Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
22.73Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
22.73Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.73Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
22.73Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
22.73Single6TOTLemborexant6TOT-OX1-Lemborexant
22.73Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.73Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
22.73Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
22.73Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
22.73Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
22.73Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
22.73Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
22.73Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
22.73Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.73Single7V3ZCP559407V3Z-CB1-CP55940
22.73Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
22.73Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
22.73Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
22.73Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
22.73Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
22.73Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
22.73Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
22.73Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
22.73Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
22.73Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.73Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
22.73Single8JJOAlprenolol8JJO-β2-Alprenolol
22.73Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.73Single8RLNLUF58348RLN-A2A-LUF5834
22.73Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.73Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
22.73Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.73Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
22.73Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.73Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
22.73Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
22.73Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
22.73Consensus5ht5_onOrthosteric Ligand5ht5a_on
22.73Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.73Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
22.73Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
22.73Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.73Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.73Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
22.73Consensusdopamine_offOrthosteric Ligandd2_off d3_off
22.73Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
22.73Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
22.73Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
22.58Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.58Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
22.58Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
22.58Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.58Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
22.22Single3OE8IT1t3OE8-CXCR4-IT1t
22.22Single3RFMCaffeine3RFM-A2A-Caffeine
22.22Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
22.22Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.22Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.22Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
22.22Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
22.22Single8IEBA1LYA8IEB-GPR156-A1LYA
22.22Single8IEIA1LYA8IEI-GPR156-A1LYA
22.22Single8IEPA1LYA8IEP-GPR156-A1LYA
22.22Single8IEPA1LYA8IEP-GPR156-A1LYA
22.22Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
22.22Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
22.22Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
22.22Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
22.22Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
22.22Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
21.88Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
21.88Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
21.88Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.88Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.74Single2RH1S-Carazolol2RH1-β2-S-Carazolol
21.74Single2YCWS-Carazolol2YCW-β1-S-Carazolol
21.74Single5C1MBU725C1M-μ-BU72
21.74Single5D6LS-Carazolol5D6L-β2-S-Carazolol
21.74Single5JQHS-Carazolol5JQH-β2-S-Carazolol
21.74Single5TVNLSD5TVN-5-HT2B-LSD
21.74Single5WQCEMPA5WQC-OX2-EMPA
21.74Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
21.74Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.74Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.74Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
21.74Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.74Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.74Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
21.74Single6PS6Timolol6PS6-β2-Timolol
21.74Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.74Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.74Single6TP6Filorexant6TP6-OX1-Filorexant
21.74Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
21.74Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
21.74Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
21.74Single7C4SS1P7C4S-S1P3-S1P
21.74Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.74Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.74Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.74Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
21.74Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
21.74Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
21.74Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.74Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
21.74Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
21.74Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
21.74Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
21.74Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
21.74Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
21.74Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
21.74Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
21.74Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
21.74Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.74Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
21.74Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
21.74Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
21.74Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
21.74Consensusamine_offonOrthosteric Ligandamine_off amine_on
21.74Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
21.74Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
21.74Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
21.74Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
21.74Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
21.74Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.74Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.74Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.74Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.74Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.74Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.74Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.74Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Consensustrace-amine_onOrthosteric Ligandta1_on
21.43Single6HLOAprepitant6HLO-NK1-Aprepitant
21.43Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
21.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.43Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.43Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
21.43Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.21Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
21.21Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.05Single4XNWMRS25004XNW-P2Y1-MRS2500
21.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.05Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
21.05Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.05Consensus5ht2_onOrthosteric Ligand5ht2b_on
21.05Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
20.83Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.83Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
20.83Single5D5AS-Carazolol5D5A-β2-S-Carazolol
20.83Single5D5BS-Carazolol5D5B-β2-S-Carazolol
20.83Single5V56TC1145V56-SMO-TC114
20.83Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.83Single6J20Aprepitant6J20-NK1-Aprepitant
20.83Single6J21Aprepitant6J21-NK1-Aprepitant
20.83Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.83Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.83Single6OS1TRV0266OS1-AT1-TRV026
20.83Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
20.83Single6TQ7SB-3348676TQ7-OX1-SB-334867
20.83Single7B6WCyclazosin7B6W-α1b-Cyclazosin
20.83Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
20.83Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
20.83Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
20.83Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
20.83Single7FEECP559407FEE-CB1-CP55940-ZCZ011
20.83Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
20.83Single7R0CAVP7R0C-V2-AVP-Arrestin2
20.83Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
20.83Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
20.83Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.83Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
20.83Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.83Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
20.83Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
20.83Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
20.83Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
20.83Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
20.83Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
20.83Single8E0GBU728E0G-μ-BU72
20.83Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
20.83Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
20.83Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.83Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
20.83Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
20.83Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
20.83Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
20.83Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
20.83Single8XVLZibotentan8XVL-ETA-Zibotentan
20.83Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
20.83Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
20.83Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
20.83Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.83Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.83Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Consensuslpa_onOrthosteric Ligandlpa1_on
20.83Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.83Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.83Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
20.69Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
20.69Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.69Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.69Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
20.69Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.00Single3D4STimolol3D4S-β2-Timolol
20.00Single4LDEBI1671074LDE-β2-BI167107
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
20.00Single5L7IVismodegib5L7I-SMO-Vismodegib
20.00Single6A93Risperidone6A93-5-HT2A-Risperidone
20.00Single6CM4Risperidone6CM4-D2-Risperidone
20.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
20.00Single6HLLCP999946HLL-NK1-CP99994
20.00Single6KQICP559406KQI-CB1-CP55940-Org27569
20.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
20.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7SRQLSD7SRQ-5-HT2B-LSD
20.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.00Single7UL2SR486927UL2-NTS1-SR48692-Na
20.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
20.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Single7YITNalfurafine7YIT-κ-Nalfurafine
20.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
20.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
20.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
20.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.00Single8XQJJN2418XQJ-Apelin-JN241
20.00Single8XWACXCL18XWA-CXCR2-CXCL1
20.00Single8XWMCXCL68XWM-CXCR2-CXCL6
20.00Single8XWSCXCL58XWS-CXCR2-CXCL5
20.00Single8XYIVUF106618XYI-CXCR3-VUF10661
20.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
20.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
20.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
20.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
20.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Consensusneurotensin_offOrthosteric Ligandnts1_off
20.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
20.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
20.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
19.44Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
19.44Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
19.44Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
19.35Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
19.23Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
19.23Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
19.23Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
19.23Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
19.23Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
19.23Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
19.23Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
19.23Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
19.23Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
19.23Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
19.23Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
19.23Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
19.23Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
19.23Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
19.23Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
19.23Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
19.23Single8XWFCXCL38XWF-CXCR2-CXCL3
19.23Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
19.23Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
19.23Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
19.23Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
19.23Consensusendothelin_offOrthosteric Ligandetb_off
19.23Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
19.05Single4BWBNeurotensin4BWB-NTS1-Neurotensin
19.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
19.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
19.05Single5WS3EMPA5WS3-OX2-EMPA
19.05Single6AKXA4R6AKX-CCR5-A4R
19.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
19.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
19.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
19.05Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
19.05Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
19.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
19.05Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
19.05Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
19.05Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
19.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
19.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
19.05Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
19.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
19.05Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
19.05Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
19.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
19.05Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
19.05Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
19.05Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
19.05Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
19.05Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
19.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
19.05Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
19.05Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
19.05Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
19.05Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
19.05Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
19.05Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.05Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
19.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.05Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
19.05Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
19.05Consensusangiotensin_offOrthosteric Ligandat1_off
19.05Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.05Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
19.05Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
19.05Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.05Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.92Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
18.92Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
18.92Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
18.75Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
18.75Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
18.52Single5EE7MK08935EE7-Glucagon-MK0893
18.52Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.52Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
18.52Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
18.52Single8IEIA1LYA8IEI-GPR156-A1LYA
18.52Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
18.52Single8X5YAstemizole8X5Y-H1-Astemizole
18.52Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
18.42Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.18Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.18Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
18.18Single4MBSMaraviroc4MBS-CCR5-Maraviroc
18.18Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
18.18Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.18Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
18.18Single6IQLL7458706IQL-D4-L745870
18.18Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
18.18Single6KUXRS-799486KUX-α2a-RS-79948
18.18Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
18.18Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
18.18Single6TP3Nemorexant6TP3-OX1-Nemorexant
18.18Single6TPGEMPA6TPG-OX2-EMPA
18.18Single6TPKRetosiban6TPK-OT-Retosiban
18.18Single6TPNHTL66416TPN-OX2-HTL6641
18.18Single6ZINSR486926ZIN-NTS1-SR48692
18.18Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
18.18Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
18.18Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
18.18Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
18.18Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
18.18Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
18.18Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
18.18Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
18.18Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
18.18Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
18.18Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
18.18Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
18.18Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.18Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
18.18Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
18.18Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
18.18Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
18.18Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
18.18Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
18.18Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
18.18Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
18.18Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
18.18Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
18.18Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
18.18Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
18.18Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
18.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
18.18Consensusalpha1_onOrthosteric Ligandalpha1a_on
18.18Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
18.18Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.18Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
18.18Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
18.18Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.18Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
18.18Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.18Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.18Consensusvasop-oxy_offOrthosteric Ligandot_off
17.86Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
17.86Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Single8KIGSHU91198KIG-MC3-SHU9119-Ca
17.86Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.86Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.86Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.86Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
17.65Single5MZPCaffeine5MZP-A2A-Caffeine-Na
17.65Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
17.65Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
17.65Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
17.65Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
17.65Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.65Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.65Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
17.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
17.39Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
17.39Single2Y04Salbutamol2Y04-β1-Salbutamol
17.39Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
17.39Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.39Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
17.39Single5T04Neurotensin5T04-NTS1-Neurotensin
17.39Single6DRXLisuride6DRX-5-HT2B-Lisuride
17.39Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.39Single6H7MSalbutamol6H7M-β1-Salbutamol
17.39Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
17.39Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
17.39Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
17.39Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
17.39Single7BU7BI1671077BU7-β1-BI167107
17.39Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
17.39Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
17.39Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.39Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
17.39Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
17.39Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
17.39Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
17.39Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
17.39Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
17.39Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Single7WC7Lisuride7WC7-5-HT2A-Lisuride
17.39Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.39Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
17.39Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
17.39Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
17.39Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
17.39Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.39Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
17.39Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
17.39Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
17.39Single8JXRLSD8JXR-D1-LSD
17.39Single8T1WCVN4248T1W-GPR6-CVN424
17.39Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
17.39Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
17.39Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
17.39Single8X63Mepyramine8X63-H1-Mepyramine
17.39Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
17.39Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
17.39Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
17.39Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
17.39Single9IYAONO-97105319IYA-GPR55-ONO-9710531
17.39Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.39Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
17.39Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
17.39Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
17.39Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
17.39Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
17.39Consensusalpha2_onOrthosteric Ligandalpha2b_on
17.39Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
17.39Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
17.39Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
17.39Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
17.39Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Consensusblt_onOrthosteric Ligandblt1_on
17.39Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
17.39Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
17.39Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.39Consensushistamine_offOrthosteric Ligandh1_off
17.39Consensusleukotriene_onOrthosteric Ligandblt_on
17.39Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
17.24Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
17.24Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
17.24Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.24Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single2Y00Dobutamine2Y00-β1-Dobutamine
16.67Single2Y03Isoprenaline2Y03-β1-Isoprenaline
16.67Single4JKVTaladegib4JKV-SMO-Taladegib
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single5WIUNemonapride5WIU-D4-Nemonapride
16.67Single5WIVNemonapride5WIV-D4-Nemonapride-Na
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
16.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
16.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
16.67Single6Z4SSR486926Z4S-NTS1-SR48692
16.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
16.67Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7SINNPS-21437SIN-CaS-NPS-2143
16.67Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
16.67Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
16.67Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
16.67Single7WC6LSD7WC6-5-HT2A-LSD
16.67Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
16.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
16.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
16.67Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
16.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
16.67Single8JXSPF-61428JXS-D1-PF-6142
16.67Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
16.67Single8ZMFA1L108ZMF-5-HT2C-A1L10
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
16.67Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
16.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
16.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
16.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
16.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
16.67Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
16.67Consensusblt_offOrthosteric Ligandblt1_off
16.67Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
16.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
16.67Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
16.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
16.13Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
16.13Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
16.13Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
16.00Single4DJHJDTic4DJH-κ-JDTic
16.00Single5TZRMK86665TZR-FFA1-MK8666
16.00Single5V57TC1145V57-SMO-TC114
16.00Single6E59L-7607356E59-NK1-L-760735
16.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
16.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
16.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
16.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
16.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
16.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
16.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
16.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
16.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
16.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
16.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
16.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
16.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
16.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
16.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.00Consensustachykinin_offOrthosteric Ligandnk1_off
15.79Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.79Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.79Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
15.79Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.79Single9CHUNoradrenaline9CHU-β2-Noradrenaline
15.79Consensusp2y_offOrthosteric Ligandp2y1_off
15.62Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
15.62Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.38Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.38Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
15.38Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
15.38Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
15.38Single7DFPSpiperone7DFP-D2-Spiperone
15.38Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
15.38Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
15.38Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
15.38Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
15.38Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.38Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
15.38Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.38Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
15.38Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
15.38Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.38Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
15.15Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
15.15Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
15.15Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
15.15Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
15.15Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.00Single3UZAGTPL92363UZA-A2A-GTPL9236
15.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
15.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
15.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
15.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
15.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
15.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
15.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
15.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
15.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.81Single5X93K-87945X93-ETB-K-8794
14.81Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
14.81Single6K1QIRL25006K1Q-ETB-IRL2500
14.81Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
14.81Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
14.81Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
14.81Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.81Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8XVJMacitentan8XVJ-ETA-Macitentan
14.81Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
14.81Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.81Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.81Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
14.71Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
14.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
14.71Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
14.29Single3PBLEticlopride3PBL-D3-Eticlopride
14.29Single4O9RCyclopamine4O9R-SMO-Cyclopamine
14.29Single6KNMJN241-96KNM-Apelin-JN241-9
14.29Single6TP4ACT-4622066TP4-OX1-ACT-462206
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
14.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
14.29Single7SK9CCX6627SK9-ACKR3-CCX662
14.29Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
14.29Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
14.29Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
14.29Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
14.29Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.29Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
14.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
14.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
14.29Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.29Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.29Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
14.29Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
14.29Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
14.29Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
14.29Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
14.29Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
14.29Single9B9Y7DY9B9Y-CB1-7DY
14.29Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
14.29Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
14.29Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
14.29Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.29Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.29Consensuskisspeptin_onOrthosteric Ligandkiss1_on
13.95Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.89Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.89Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
13.89Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
13.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
13.79Single7QA8Peptide7QA8-STE2-Peptide
13.79Single7QA8Peptide7QA8-STE2-Peptide
13.79Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.64Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
13.64Single4QINSAG1.54QIN-SMO-SAG1.5
13.64Single5U09Taranabant5U09-CB1-Taranabant
13.64Single6AKYMaraviroc6AKY-CCR5-Maraviroc
13.64Single6B73MP11046B73-κ-MP1104
13.64Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.64Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.64Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.64Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
13.64Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
13.64Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
13.64Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
13.64Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
13.64Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.64Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.64Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.64Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.64Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
13.64Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
13.64Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
13.64Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
13.64Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
13.64Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
13.64Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
13.64Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
13.64Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
13.64Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.64Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
13.64Single8Y0HVUF114188Y0H-CXCR3-VUF11418
13.64Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
13.64Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
13.64Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.64Single9BA0A1AKN9BA0-CB1-A1AKN
13.64Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
13.64Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.64Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.64Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.64Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.64Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
13.64Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
13.64Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.64Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.64Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
13.51Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
13.16Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
13.04Single3RZECidoxepin3RZE-H1-Cidoxepin
13.04Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.04Single6A94Zotepine6A94-5-HT2A-Zotepine
13.04Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.04Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.04Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.04Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.04Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
13.04Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.04Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
13.04Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
13.04Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
13.04Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
13.04Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.04Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.04Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.04Single7VV6C48/807VV6-MRGPRX2-C48/80
13.04Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.04Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.04Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.04Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
13.04Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
13.04Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
13.04Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.04Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.04Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
13.04Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
13.04Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
13.04Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
13.04Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.04Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9BJKNaloxone9BJK-μ-Naloxone-NAM
13.04Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
13.04Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
13.04Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.82Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.82Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
12.50Single2Y01Dobutamine2Y01-β1-Dobutamine
12.50Single4DAJTiotropium4DAJ-M3-Tiotropium
12.50Single4MQSIperoxo4MQS-M2-Iperoxo
12.50Single4U14Tiotropium4U14-M3-Tiotropium
12.50Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
12.50Single5TGZAM65385TGZ-CB1-AM6538
12.50Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.50Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.50Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.50Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
12.50Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.50Single6IIVDaltroban6IIV-TP-Daltroban
12.50Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.50Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.50Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.50Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
12.50Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.50Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
12.50Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
12.50Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
12.50Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
12.50Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
12.50Single8X64Desloratadine8X64-H1-Desloratadine
12.50Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single9B9ZA1AKO9B9Z-CB1-A1AKO
12.50Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
12.50Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.50Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.50Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.50Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.12Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.12Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.12Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
12.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
12.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
12.00Single5CGCHTL142425CGC-mGlu5-HTL14242
12.00Single5XPRBosentan5XPR-ETB-Bosentan
12.00Single6HLPNetupitant6HLP-NK1-Netupitant
12.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
12.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
12.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
12.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
12.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
11.76Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
11.76Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.54Single4U15Tiotropium4U15-M3-Tiotropium
11.54Single5V54Methiothepin5V54-5-HT1B-Methiothepin
11.54Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
11.54Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
11.54Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.54Single6OL9Tiotropium6OL9-M5-Tiotropium
11.54Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
11.54Single7P2L4YI7P2L-mGlu5-4YI
11.54Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
11.54Single8EA0Iperoxo8EA0-M3-Iperoxo
11.54Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
11.54Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.54Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.54Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.54Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
11.54Single9BJKNAM9BJK-μ-Naloxone-NAM
11.54Consensus5ht1_offOrthosteric Ligand5ht1b_off
11.54Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
11.54Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
11.54Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
11.54Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.54Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.54Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.54Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
11.54Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
11.54Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
11.54Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
11.43Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
11.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.43Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
11.11Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.11Single5CXVTiotropium5CXV-M1-Tiotropium
11.11Single5X33BIIL2605X33-BLT1-BIIL260
11.11Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.11Single6IIURamatroban6IIU-TP-Ramatroban
11.11Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.11Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.11Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.11Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
11.11Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.11Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.11Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.11Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
11.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
11.11Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.11Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.11Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
11.11Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.71Single5CGDHTL142425CGD-mGlu5-HTL14242
10.71Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
10.53Single7WC4Serotonin7WC4-5-HT2A-Serotonin
10.53Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.53Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.53Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
10.53Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.34Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.34Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.34Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
10.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
10.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
10.00Consensussensory_onOrthosteric Ligandopsins_on
9.52Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.52Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
9.52Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
9.52Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
9.52Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
9.52Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
9.52Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
9.52Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
9.52Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.52Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
9.52Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Single8JPSCCL78JPS-ACKR1-CCL7
9.52Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.52Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
9.52Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
9.52Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.52Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
9.52Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.52Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.52Consensusgi_sensoryOrthosteric Ligandgi_opsins
9.52Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
9.52Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.52Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.52Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
9.52Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.52Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
9.09Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.09Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.09Single6LI0C176LI0-GPR52-C17
9.09Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.09Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
9.09Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.09Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.09Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
9.09Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.09Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
8.70Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.70Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.70Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
8.70Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
8.70Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
8.70Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
8.70Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.70Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.70Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.70Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
8.70Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
8.70Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
8.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
8.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
8.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8K2WAMG4878K2W-CXCR3-AMG487
8.33Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.33Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
8.33Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
8.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
8.33Consensussensory_offOrthosteric Ligandopsins_off
8.00Single5DSGTiotropium5DSG-M4-Tiotropium
8.00Single6GPSMK08126GPS-CCR2-MK0812
8.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
8.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
8.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
7.69Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
7.69Single6GPXMK08126GPX-CCR2-MK0812
7.69Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.69Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
7.41Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
7.41Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
7.14Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
7.14Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
6.90Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.90Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
6.90Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.90Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
6.67Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.45Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.45Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
5.56Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.26Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.00Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
4.76Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
4.76Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.76Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.55Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.55Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.55Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.55Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.35Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.35Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.35Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
4.35Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.35Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.35Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.35Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.35Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
4.35Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.35Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
4.35Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
4.17Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
4.17Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
4.17Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.17Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
4.17Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
4.17Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
4.17Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
4.17Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
4.17Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
4.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.85Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.85Single6FFHFenobam6FFH-mGlu5-Fenobam
3.85Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.57Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.57Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.45Single7SHEPI; PE7SHE-GPR158-PI; PE
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
8IA7 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
7XOW 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
7EZM 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
7F8W 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
Net Summary
Imin 3.2
Number of Linked Nodes 885
Number of Links 1019
Number of Hubs 137
Number of Links mediated by Hubs 568
Number of Communities 23
Number of Nodes involved in Communities 182
Number of Links involved in Communities 253
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 1329055
Length Of Smallest Path 3
Average Path Length 44.0512
Length of Longest Path 80
Minimum Path Strength 0.37625
Average Path Strength 5.70442
Maximum Path Strength 23.425
Minimum Path Correlation 0.7
Average Path Correlation 0.968135
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.35135
Average % Of Corr. Nodes 34.3029
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.0197
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gq_peptidegq_cck
gq_kisspeptin
gq_bradykinin
gq_bombesin
gq_angiotensin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gq_cck.zip



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