psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S31	L:L:T32	1.6	No	No	0	5	4
2	L:L:T32	R:R:S53	7.99	No	No	0	4	9
3	L:L:T33	R:R:P50	1.75	No	Yes	2	4	9
4	L:L:T33	R:R:H52	9.58	No	No	2	4	7
5	L:L:C34	L:L:C59	7.28	No	No	5	9	9
6	L:L:C34	L:L:P60	3.77	No	No	5	9	4
7	L:L:C34	R:R:Q279	7.63	No	No	0	9	8
8	L:L:A63	L:L:C35	1.81	No	No	2	9	9
9	L:L:C35	L:L:C75	7.28	No	No	2	9	9
10	L:L:C35	R:R:P50	1.88	No	Yes	2	9	9
11	L:L:R37	L:L:Y36	10.29	No	No	0	3	4
12	L:L:Y36	R:R:C276	2.69	No	No	0	4	9
13	L:L:I39	L:L:R37	3.76	No	No	0	4	3
14	L:L:F38	L:L:R61	23.52	No	No	6	5	3
15	L:L:D77	L:L:F38	16.72	Yes	No	6	8	5
16	L:L:I39	L:L:K41	5.82	No	No	0	4	5
17	L:L:I39	R:R:A48	1.62	No	No	0	4	7
18	L:L:D77	L:L:N40	2.69	Yes	No	0	8	3
19	L:L:N40	L:L:Q80	13.2	No	No	0	3	4
20	L:L:K41	R:R:E46	5.4	No	No	0	5	3
21	L:L:K42	L:L:W82	2.32	No	No	0	4	9
22	L:L:I43	L:L:P44	5.08	No	No	0	7	8
23	L:L:F86	L:L:I43	8.79	No	No	0	4	7
24	L:L:P44	L:L:R47	4.32	No	No	0	8	3
25	L:L:K69	L:L:R47	6.19	No	No	0	5	3
26	L:L:L70	L:L:R47	8.5	No	No	0	5	3
27	L:L:F66	L:L:L48	3.65	Yes	No	0	8	7
28	L:L:L48	L:L:T68	4.42	No	No	0	7	9
29	L:L:E49	L:L:S50	8.62	No	No	9	1	8
30	L:L:E49	L:L:K67	9.45	No	Yes	9	1	4
31	L:L:E49	L:L:K69	4.05	No	No	0	1	5
32	L:L:K67	L:L:S50	7.65	Yes	No	9	4	8
33	L:L:V64	L:L:Y51	6.31	No	Yes	8	8	8
34	L:L:F66	L:L:Y51	12.38	Yes	Yes	8	8	8
35	L:L:M87	L:L:Y51	4.79	No	Yes	0	5	8
36	L:L:L90	L:L:Y51	5.86	No	Yes	0	7	8
37	L:L:I65	L:L:R52	10.02	No	No	0	8	4
38	L:L:E73	L:L:R52	15.12	No	No	0	3	4
39	L:L:S56	L:L:T54	1.6	No	No	0	7	7
40	L:L:A63	L:L:T54	1.68	No	No	0	9	7
41	L:L:S57	L:L:T55	4.8	No	No	0	7	8
42	L:L:C59	L:L:S56	1.72	No	No	0	9	7
43	L:L:H58	L:L:S57	6.97	Yes	No	1	4	7
44	L:L:S57	R:R:R267	3.95	No	Yes	1	7	6
45	L:L:H58	R:R:D263	3.78	Yes	No	1	4	9
46	L:L:H58	R:R:R267	9.03	Yes	Yes	1	4	6
47	L:L:C59	L:L:P60	5.65	No	No	5	9	4
48	L:L:P60	R:R:L273	4.93	No	No	0	4	5
49	L:L:D77	L:L:R61	8.34	Yes	No	6	8	3
50	L:L:E62	L:L:P78	6.29	No	No	0	4	9
51	L:L:A63	L:L:C75	1.81	No	No	2	9	9
52	L:L:F66	L:L:V64	9.18	Yes	No	8	8	8
53	L:L:P78	L:L:V64	1.77	No	No	0	9	8
54	L:L:C75	L:L:I65	1.64	No	No	0	9	8
55	L:L:I65	R:R:P50	1.69	No	Yes	0	8	9
56	L:L:F66	L:L:F86	2.14	Yes	No	0	8	4
57	L:L:E73	L:L:K67	12.15	No	Yes	0	3	4
58	L:L:L70	L:L:T68	4.42	No	No	7	5	9
59	L:L:K72	L:L:T68	3	No	No	7	5	9
60	L:L:K72	L:L:L70	7.05	No	No	7	5	5
61	L:L:I74	R:R:A48	1.62	No	No	0	6	7
62	L:L:A76	L:L:V83	1.7	No	No	0	8	9
63	L:L:D77	L:L:P78	6.44	Yes	No	0	8	9
64	L:L:D77	L:L:T79	8.67	Yes	No	0	8	1
65	L:L:K81	L:L:W82	3.48	No	No	0	2	9
66	L:L:D85	L:L:H89	7.56	No	No	0	3	1
67	L:L:K92	L:L:L90	4.23	No	No	0	3	7
68	L:L:D91	L:L:K93	11.06	No	No	0	6	6
69	R:R:A49	R:R:P50	1.87	No	Yes	0	8	9
70	R:R:H52	R:R:P50	3.05	No	Yes	2	7	9
71	R:R:C276	R:R:C51	7.28	No	No	0	9	9
72	R:R:N55	R:R:S53	7.45	No	No	0	3	9
73	R:R:D283	R:R:S53	4.42	No	No	0	9	9
74	R:R:C54	R:R:D283	7.78	No	No	0	9	9
75	R:R:C54	R:R:L284	1.59	No	No	0	9	4
76	R:R:D58	R:R:N55	8.08	No	No	0	7	3
77	R:R:L56	R:R:N287	4.12	No	No	0	6	5
78	R:R:F65	R:R:L57	2.44	No	No	0	9	8
79	R:R:L57	R:R:N287	9.61	No	No	0	8	5
80	R:R:E290	R:R:L57	2.65	No	No	0	7	8
81	R:R:D59	R:R:P118	1.61	No	Yes	4	3	7
82	R:R:D59	R:R:G119	6.71	No	No	4	3	9
83	R:R:A61	R:R:F64	2.77	No	No	0	9	9
84	R:R:L62	R:R:P63	1.64	No	No	0	8	6
85	R:R:I66	R:R:L62	2.85	No	No	0	7	8
86	R:R:G119	R:R:L62	1.71	No	No	0	9	8
87	R:R:A117	R:R:F65	6.93	No	No	4	8	9
88	R:R:F65	R:R:P118	10.11	No	Yes	4	9	7
89	R:R:I66	R:R:P114	1.69	No	No	0	7	9
90	R:R:T68	R:R:V113	1.59	No	Yes	0	5	8
91	R:R:S69	R:R:V113	8.08	No	Yes	1	8	8
92	R:R:P114	R:R:S69	10.69	No	No	1	9	8
93	R:R:G72	R:R:L71	1.71	No	No	10	9	5
94	R:R:L71	R:R:V298	5.96	No	No	10	5	6
95	R:R:G72	R:R:S110	3.71	No	No	0	9	8
96	R:R:G72	R:R:V298	1.84	No	No	10	9	6
97	R:R:I111	R:R:I73	5.89	No	No	0	4	4
98	R:R:L74	R:R:T78	2.95	No	No	0	9	6
99	R:R:S106	R:R:S76	1.63	Yes	Yes	1	7	7
100	R:R:A107	R:R:S76	3.42	No	Yes	0	5	7
101	R:R:S110	R:R:S76	3.26	No	Yes	0	8	7
102	R:R:P301	R:R:S76	1.78	Yes	Yes	1	9	7
103	R:R:F81	R:R:S77	2.64	No	No	0	6	5
104	R:R:A103	R:R:V79	1.7	No	No	0	8	7
105	R:R:P301	R:R:V79	7.07	Yes	No	0	9	7
106	R:R:F84	R:R:L80	9.74	No	No	0	5	8
107	R:R:A103	R:R:L80	1.58	No	No	0	8	8
108	R:R:F81	R:R:F84	4.29	No	No	0	6	5
109	R:R:F88	R:R:M82	11.2	No	No	0	5	7
110	R:R:L83	R:R:W90	5.69	No	Yes	3	8	6
111	R:R:L83	R:R:W96	4.56	No	Yes	3	8	8
112	R:R:A100	R:R:L83	1.58	No	No	3	6	8
113	R:R:L87	R:R:R85	2.43	No	No	0	7	7
114	R:R:F88	R:R:R85	3.21	No	No	0	5	7
115	R:R:F88	R:R:W90	2	No	Yes	0	5	6
116	R:R:C308	R:R:W90	6.53	No	Yes	3	6	6
117	R:R:H309	R:R:W90	9.52	No	Yes	3	6	6
118	R:R:C93	R:R:P94	1.88	No	No	0	7	6
119	R:R:G95	R:R:P97	2.03	No	Yes	0	5	5
120	R:R:P97	R:R:W96	9.46	Yes	Yes	0	5	8
121	R:R:A100	R:R:W96	2.59	No	Yes	3	6	8
122	R:R:Q161	R:R:W96	3.29	No	Yes	0	5	8
123	R:R:P97	R:R:Q101	1.58	Yes	Yes	0	5	9
124	R:R:P97	R:R:T166	1.75	Yes	No	0	5	8
125	R:R:Q101	R:R:V98	2.87	Yes	No	0	9	5
126	R:R:H150	R:R:V98	5.54	No	No	0	4	5
127	R:R:L304	R:R:L99	4.15	No	No	0	8	9
128	R:R:L146	R:R:Q101	3.99	No	Yes	0	8	9
129	R:R:Q101	R:R:T170	11.34	Yes	No	11	9	6
130	R:R:Q101	R:R:W174	2.19	Yes	Yes	11	9	9
131	R:R:L102	R:R:Q143	6.65	Yes	Yes	1	7	9
132	R:R:L102	R:R:L147	4.15	Yes	No	0	7	8
133	R:R:L102	R:R:W249	2.28	Yes	Yes	1	7	9
134	R:R:L102	R:R:T300	4.42	Yes	Yes	1	7	5
135	R:R:L102	R:R:L304	8.3	Yes	No	0	7	8
136	R:R:A103	R:R:L304	1.58	No	No	0	8	8
137	R:R:G105	R:R:V104	1.84	No	No	0	7	7
138	R:R:G105	R:R:Q143	3.29	No	Yes	0	7	9
139	R:R:Q143	R:R:S106	5.78	Yes	Yes	1	9	7
140	R:R:H296	R:R:S106	2.79	Yes	Yes	1	9	7
141	R:R:S106	R:R:T300	6.4	Yes	Yes	1	7	5
142	R:R:P301	R:R:S106	7.13	Yes	Yes	1	9	7
143	R:R:A107	R:R:I111	1.62	No	No	0	5	4
144	R:R:L108	R:R:W174	2.28	No	Yes	0	8	9
145	R:R:F109	R:R:V112	2.62	Yes	Yes	1	8	5
146	R:R:F109	R:R:V113	2.62	Yes	Yes	1	8	8
147	R:R:F109	R:R:W136	21.05	Yes	Yes	1	8	8
148	R:R:F109	R:R:S139	2.64	Yes	No	0	8	8
149	R:R:F109	R:R:W253	4.01	Yes	Yes	1	8	9
150	R:R:F109	R:R:H296	10.18	Yes	Yes	1	8	9
151	R:R:C297	R:R:F109	9.78	No	Yes	1	9	8
152	R:R:C297	R:R:S110	5.16	No	No	0	9	8
153	R:R:V112	R:R:V115	1.6	Yes	No	1	5	4
154	R:R:G132	R:R:V112	1.84	Yes	Yes	1	8	5
155	R:R:V112	R:R:V135	4.81	Yes	No	1	5	6
156	R:R:V112	R:R:W136	2.45	Yes	Yes	1	5	8
157	R:R:P114	R:R:V113	3.53	No	Yes	1	9	8
158	R:R:I294	R:R:V113	6.14	No	Yes	0	7	8
159	R:R:C297	R:R:V113	1.71	No	Yes	1	9	8
160	R:R:L128	R:R:V115	4.47	No	No	0	7	4
161	R:R:G132	R:R:V115	1.84	Yes	No	1	8	4
162	R:R:G132	R:R:L116	1.71	Yes	Yes	1	8	7
163	R:R:L116	R:R:Y133	5.86	Yes	Yes	1	7	6
164	R:R:L116	R:R:W136	9.11	Yes	Yes	1	7	8
165	R:R:C195	R:R:L116	3.17	Yes	Yes	1	9	7
166	R:R:A117	R:R:P118	1.87	No	Yes	4	8	7
167	R:R:G119	R:R:P118	2.03	No	Yes	4	9	7
168	R:R:L194	R:R:P118	4.93	No	Yes	0	3	7
169	R:R:L120	R:R:R124	4.86	No	Yes	0	5	4
170	R:R:L128	R:R:R124	2.43	No	Yes	0	7	4
171	R:R:C129	R:R:R124	2.79	Yes	Yes	1	9	4
172	R:R:G193	R:R:R124	3	No	Yes	0	5	4
173	R:R:C195	R:R:R124	2.79	Yes	Yes	1	9	4
174	R:R:A127	R:R:S125	1.71	No	No	0	3	6
175	R:R:G189	R:R:S126	3.71	No	No	0	5	4
176	R:R:A190	R:R:S126	1.71	No	No	0	6	4
177	R:R:A127	R:R:L128	1.58	No	No	0	3	7
178	R:R:A127	R:R:S130	1.71	No	No	0	3	3
179	R:R:C129	R:R:S188	1.72	Yes	No	0	9	7
180	R:R:A190	R:R:C129	1.81	No	Yes	0	6	9
181	R:R:C129	R:R:C195	7.28	Yes	Yes	1	9	9
182	R:R:S130	R:R:T185	1.6	No	No	0	3	8
183	R:R:G132	R:R:L131	1.71	Yes	No	0	8	5
184	R:R:G132	R:R:V135	1.84	Yes	No	1	8	6
185	R:R:V184	R:R:Y133	2.52	Yes	Yes	1	6	6
186	R:R:S188	R:R:Y133	7.63	No	Yes	0	7	6
187	R:R:C195	R:R:Y133	4.03	Yes	Yes	1	9	6
188	R:R:L197	R:R:Y133	3.52	No	Yes	1	4	6
189	R:R:C134	R:R:T181	6.76	No	No	0	4	8
190	R:R:C134	R:R:T185	8.45	No	No	0	4	8
191	R:R:S139	R:R:V135	1.62	No	No	0	8	6
192	R:R:W136	R:R:Y137	7.72	Yes	Yes	1	8	7
193	R:R:W136	R:R:W253	2.81	Yes	Yes	1	8	9
194	R:R:E290	R:R:W136	3.27	No	Yes	0	7	8
195	R:R:I294	R:R:W136	3.52	No	Yes	0	7	8
196	R:R:F141	R:R:Y137	4.13	Yes	Yes	1	9	7
197	R:R:V184	R:R:Y137	10.09	Yes	Yes	1	6	7
198	R:R:H210	R:R:Y137	9.8	Yes	Yes	1	9	7
199	R:R:C214	R:R:Y137	2.69	Yes	Yes	1	6	7
200	R:R:H256	R:R:Y137	7.62	Yes	Yes	1	8	7
201	R:R:G138	R:R:T181	1.82	No	No	0	5	8
202	R:R:A140	R:R:F218	2.77	No	Yes	1	8	9
203	R:R:A140	R:R:W253	5.19	No	Yes	1	8	9
204	R:R:F141	R:R:L180	3.65	Yes	No	0	9	8
205	R:R:C214	R:R:F141	2.79	Yes	Yes	1	6	9
206	R:R:F141	R:R:I217	7.54	Yes	No	1	9	5
207	R:R:F141	R:R:F218	6.43	Yes	Yes	1	9	9
208	R:R:A142	R:R:W174	7.78	No	Yes	0	8	9
209	R:R:A142	R:R:A177	1.79	No	No	0	8	9
210	R:R:Q143	R:R:W249	15.33	Yes	Yes	1	9	9
211	R:R:H296	R:R:Q143	9.89	Yes	Yes	1	9	9
212	R:R:Q143	R:R:T300	2.83	Yes	Yes	1	9	5
213	R:R:A144	R:R:I217	1.62	No	No	1	9	5
214	R:R:A144	R:R:W249	3.89	No	Yes	1	9	9
215	R:R:A144	R:R:F250	2.77	No	Yes	1	9	8
216	R:R:I173	R:R:L145	2.85	No	No	0	4	9
217	R:R:A177	R:R:L145	1.58	No	No	0	9	9
218	R:R:I173	R:R:L146	5.71	No	No	0	4	8
219	R:R:L147	R:R:L246	4.15	No	No	0	8	7
220	R:R:F250	R:R:L147	2.44	Yes	No	0	8	8
221	R:R:A151	R:R:G148	1.95	No	No	1	7	5
222	R:R:G148	R:R:L221	1.71	No	Yes	1	5	8
223	R:R:G148	R:R:L225	1.71	No	Yes	1	5	8
224	R:R:C149	R:R:L153	4.76	No	Yes	12	5	8
225	R:R:C149	R:R:L169	6.35	No	No	12	5	5
226	R:R:C149	R:R:I173	3.27	No	No	0	5	4
227	R:R:H150	R:R:L157	2.57	No	No	0	4	6
228	R:R:A151	R:R:L225	1.58	No	Yes	1	7	8
229	R:R:A151	R:R:W247	2.59	No	Yes	1	7	6
230	R:R:L153	R:R:S152	3	Yes	No	0	8	4
231	R:R:L153	R:R:R156	3.64	Yes	No	0	8	4
232	R:R:L153	R:R:L169	2.77	Yes	No	12	8	5
233	R:R:G154	R:R:L157	1.71	No	No	0	6	6
234	R:R:L165	R:R:R156	3.64	No	No	0	4	4
235	R:R:A159	R:R:V162	1.7	No	No	0	4	5
236	R:R:P163	R:R:V162	3.53	No	No	0	5	5
237	R:R:L165	R:R:V162	2.98	No	No	0	4	5
238	R:R:G164	R:R:P163	2.03	No	No	0	3	5
239	R:R:L165	R:R:L169	6.92	No	No	0	4	5
240	R:R:G168	R:R:L167	1.71	No	No	0	4	5
241	R:R:G168	R:R:V171	1.84	No	No	0	4	7
242	R:R:T170	R:R:W174	2.43	No	Yes	11	6	9
243	R:R:G172	R:R:V171	1.84	No	No	0	7	7
244	R:R:L179	R:R:V176	2.98	No	No	0	7	4
245	R:R:T181	R:R:V184	3.17	No	Yes	0	8	6
246	R:R:L182	R:R:P183	1.64	No	No	0	6	9
247	R:R:P183	R:R:T209	5.25	No	No	0	9	5
248	R:R:H210	R:R:P183	4.58	Yes	No	0	9	9
249	R:R:H210	R:R:V184	15.22	Yes	Yes	1	9	6
250	R:R:L186	R:R:L206	2.77	No	No	0	6	5
251	R:R:A187	R:R:L203	1.58	No	Yes	0	5	3
252	R:R:G189	R:R:S188	3.71	No	No	0	5	7
253	R:R:G189	R:R:I198	1.76	No	No	0	5	4
254	R:R:A190	R:R:G193	1.95	No	No	0	6	5
255	R:R:G192	R:R:G193	2.11	No	No	0	2	5
256	R:R:L194	R:R:T196	2.95	No	No	0	3	5
257	R:R:L197	R:R:Q207	5.32	No	No	1	4	4
258	R:R:H210	R:R:L197	2.57	Yes	No	1	9	4
259	R:R:Q207	R:R:Y199	14.65	No	No	1	4	5
260	R:R:D263	R:R:Y199	8.05	No	No	1	9	5
261	R:R:R267	R:R:Y199	23.66	Yes	No	1	6	5
262	R:R:E202	R:R:S200	11.5	No	No	13	3	7
263	R:R:L203	R:R:S200	9.01	Yes	No	13	3	7
264	R:R:E202	R:R:T201	4.23	No	No	0	3	3
265	R:R:K204	R:R:T201	3	No	No	0	6	3
266	R:R:E202	R:R:L203	5.3	No	Yes	13	3	3
267	R:R:L203	R:R:L206	2.77	Yes	No	0	3	5
268	R:R:H210	R:R:Q207	9.89	Yes	No	1	9	4
269	R:R:A208	R:R:F264	4.16	No	No	0	4	5
270	R:R:C214	R:R:H210	7.37	Yes	Yes	1	6	9
271	R:R:L260	R:R:T211	4.42	No	No	0	6	5
272	R:R:G261	R:R:T211	1.82	No	No	0	5	5
273	R:R:F264	R:R:T211	14.27	No	No	0	5	5
274	R:R:C214	R:R:F218	4.19	Yes	Yes	1	6	9
275	R:R:C214	R:R:L260	3.17	Yes	No	0	6	6
276	R:R:G261	R:R:L215	3.42	No	No	0	5	6
277	R:R:A216	R:R:L220	1.58	No	No	0	4	7
278	R:R:F218	R:R:I217	3.77	Yes	No	1	9	5
279	R:R:F218	R:R:W253	13.03	Yes	Yes	1	9	9
280	R:R:F218	R:R:H256	2.26	Yes	Yes	1	9	8
281	R:R:V219	R:R:W254	9.81	No	No	0	5	4
282	R:R:L221	R:R:P222	3.28	Yes	No	1	8	9
283	R:R:L221	R:R:L225	2.77	Yes	Yes	1	8	8
284	R:R:F250	R:R:L221	2.44	Yes	Yes	1	8	8
285	R:R:F250	R:R:P222	14.45	Yes	No	1	8	9
286	R:R:L225	R:R:W247	2.28	Yes	Yes	1	8	6
287	R:R:G240	R:R:P241	4.06	No	No	0	3	7
288	R:R:P241	R:R:W242	4.05	No	No	0	7	3
289	R:R:M243	R:R:W247	17.45	No	Yes	0	5	6
290	R:R:I245	R:R:N244	7.08	No	No	1	5	4
291	R:R:N244	R:R:W247	2.26	No	Yes	1	4	6
292	R:R:F307	R:R:N244	3.62	No	No	1	4	4
293	R:R:F307	R:R:I245	2.51	No	No	1	4	5
294	R:R:A248	R:R:I251	1.62	No	No	0	4	5
295	R:R:A248	R:R:L303	3.15	No	No	0	4	5
296	R:R:F250	R:R:W249	11.02	Yes	Yes	1	8	9
297	R:R:W249	R:R:W253	15.93	Yes	Yes	1	9	9
298	R:R:H296	R:R:W249	12.7	Yes	Yes	1	9	9
299	R:R:T300	R:R:W249	7.28	Yes	Yes	1	5	9
300	R:R:F252	R:R:L292	4.87	Yes	No	0	9	8
301	R:R:F252	R:R:L295	2.44	Yes	No	0	9	7
302	R:R:F252	R:R:H296	3.39	Yes	Yes	0	9	9
303	R:R:A299	R:R:F252	5.55	No	Yes	0	8	9
304	R:R:H256	R:R:W253	8.46	Yes	Yes	1	8	9
305	R:R:A293	R:R:W253	3.89	No	Yes	0	8	9
306	R:R:H296	R:R:W253	11.64	Yes	Yes	1	9	9
307	R:R:P255	R:R:W254	2.7	No	No	0	8	4
308	R:R:V258	R:R:W254	2.45	No	No	0	6	4
309	R:R:A289	R:R:P255	1.87	No	No	0	8	8
310	R:R:L292	R:R:P255	4.93	No	No	0	8	8
311	R:R:E290	R:R:H256	2.46	No	Yes	0	7	8
312	R:R:G257	R:R:L260	1.71	No	No	0	7	6
313	R:R:L285	R:R:V259	7.45	No	No	0	5	4
314	R:R:L286	R:R:V259	4.47	No	No	0	7	4
315	R:R:A289	R:R:V259	3.39	No	No	0	8	4
316	R:R:D263	R:R:R267	7.15	No	Yes	1	9	6
317	R:R:L265	R:R:L270	2.77	No	No	14	9	3
318	R:R:L265	R:R:L271	5.54	No	No	14	9	5
319	R:R:L282	R:R:V266	2.98	No	No	0	8	8
320	R:R:L270	R:R:S268	9.01	No	No	0	3	7
321	R:R:L270	R:R:L271	4.15	No	No	14	3	5
322	R:R:L273	R:R:Q279	5.32	No	No	0	5	8
323	R:R:S274	R:R:T275	6.4	No	No	0	4	7
324	R:R:A278	R:R:T275	1.68	No	No	0	7	7
325	R:R:D283	R:R:N287	4.04	No	No	0	9	5
326	R:R:H296	R:R:T300	10.95	Yes	Yes	1	9	5
327	R:R:A299	R:R:L303	1.58	No	No	0	8	5
328	R:R:P301	R:R:T300	3.5	Yes	Yes	1	9	5
329	R:R:A311	R:R:F307	2.77	No	No	0	6	4
330	R:R:C308	R:R:H309	10.32	No	No	3	6	6
331	R:R:I198	R:R:S200	1.55	No	No	0	4	7
332	R:R:C51	R:R:Q279	1.53	No	No	0	9	8
333	L:L:M87	L:L:V83	1.52	No	No	0	5	9
334	R:R:M82	R:R:T78	1.51	No	No	0	7	6
335	R:R:L108	R:R:S139	1.5	No	No	0	8	8
336	R:R:L225	R:R:S152	1.5	Yes	No	0	8	4
337	R:R:L145	R:R:V176	1.49	No	No	0	9	4
338	R:R:L180	R:R:V176	1.49	No	No	0	8	4
339	R:R:L220	R:R:V219	1.49	No	No	0	7	5
340	R:R:L273	R:R:V266	1.49	No	No	0	5	8
341	R:R:L167	R:R:T170	1.47	No	No	0	5	6
342	R:R:L277	R:R:T275	1.47	No	No	0	3	7
343	R:R:A305	R:R:H309	1.46	No	No	0	9	6
344	L:L:K41	L:L:K42	1.44	No	No	0	5	4
345	R:R:F64	R:R:P63	1.44	No	No	0	9	6
346	R:R:P86	R:R:R85	1.44	No	No	0	5	7
347	L:L:H58	R:R:V266	1.38	Yes	No	0	4	8
348	L:L:D71	L:L:K67	1.38	No	Yes	0	5	4
349	L:L:D71	L:L:K69	1.38	No	No	0	5	5
350	R:R:L262	R:R:L265	1.38	No	No	0	4	9
351	L:L:K45	L:L:Q46	1.36	No	No	0	2	3
352	L:L:K81	L:L:Q84	1.36	No	No	0	2	6
353	R:R:F264	R:R:S268	1.32	No	No	0	5	7
354	R:R:C93	R:R:W96	1.31	No	Yes	0	7	8
355	R:R:Q161	R:R:Q91	1.28	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y51	7.335	4	8	8
2	L:L:H58	5.29	4	1	4
3	L:L:F66	6.8375	4	8	8
4	L:L:K67	7.6575	4	9	4
5	L:L:D77	8.572	5	6	8
6	R:R:P50	2.048	5	2	9
7	R:R:S76	2.5225	4	1	7
8	R:R:W90	5.935	4	3	6
9	R:R:W96	4.242	5	3	8
10	R:R:P97	3.705	4	0	5
11	R:R:Q101	4.394	5	11	9
12	R:R:L102	5.16	5	1	7
13	R:R:S106	4.746	5	1	7
14	R:R:F109	7.55714	7	1	8
15	R:R:V112	2.664	5	1	5
16	R:R:V113	3.945	6	1	8
17	R:R:L116	4.9625	4	1	7
18	R:R:P118	4.11	5	4	7
19	R:R:R124	3.174	5	1	4
20	R:R:C129	3.4	4	1	9
21	R:R:G132	1.788	5	1	8
22	R:R:Y133	4.712	5	1	6
23	R:R:W136	7.13286	7	1	8
24	R:R:Y137	7.00833	6	1	7
25	R:R:F141	4.908	5	1	9
26	R:R:Q143	7.295	6	1	9
27	R:R:L153	3.5425	4	12	8
28	R:R:W174	3.67	4	11	9
29	R:R:V184	7.75	4	1	6
30	R:R:C195	4.3175	4	1	9
31	R:R:L203	4.665	4	13	3
32	R:R:H210	8.23833	6	1	9
33	R:R:C214	4.042	5	1	6
34	R:R:F218	5.40833	6	1	9
35	R:R:L221	2.55	4	1	8
36	R:R:L225	1.968	5	1	8
37	R:R:W247	6.145	4	1	6
38	R:R:W249	9.77571	7	1	9
39	R:R:F250	6.624	5	1	8
40	R:R:F252	4.0625	4	0	9
41	R:R:W253	8.12	8	1	9
42	R:R:H256	5.2	4	1	8
43	R:R:R267	10.9475	4	1	6
44	R:R:H296	8.79143	7	1	9
45	R:R:T300	5.89667	6	1	5
46	R:R:P301	4.87	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E290	R:R:L57	13.253	2.65	No	No	0	7	8
2	R:R:W136	R:R:Y137	41.5429	7.72	Yes	Yes	1	8	7
3	R:R:H210	R:R:Y137	65.0086	9.8	Yes	Yes	1	9	7
4	R:R:H210	R:R:Q207	93.769	9.89	Yes	No	1	9	4
5	R:R:Q207	R:R:Y199	100	14.65	No	No	1	4	5
6	R:R:D263	R:R:Y199	49.4893	8.05	No	No	1	9	5
7	L:L:H58	R:R:D263	49.1832	3.78	Yes	No	1	4	9
8	L:L:H58	R:R:V266	97.8451	1.38	Yes	No	0	4	8
9	R:R:L273	R:R:V266	96.3979	1.49	No	No	0	5	8
10	L:L:P60	R:R:L273	83.311	4.93	No	No	0	4	5
11	L:L:C59	L:L:P60	81.733	5.65	No	No	5	9	4
12	L:L:C59	L:L:S56	82.2298	1.72	No	No	0	9	7
13	L:L:S56	L:L:T54	81.4724	1.6	No	No	0	7	7
14	L:L:A63	L:L:T54	80.7133	1.68	No	No	0	9	7
15	R:R:H256	R:R:Y137	19.1585	7.62	Yes	Yes	1	8	7
16	R:R:R267	R:R:Y199	50.3074	23.66	Yes	No	1	6	5
17	L:L:H58	R:R:R267	49.1815	9.03	Yes	Yes	1	4	6
18	R:R:L273	R:R:Q279	12.3835	5.32	No	No	0	5	8
19	L:L:A63	L:L:C75	75.7424	1.81	No	No	2	9	9
20	L:L:Y36	R:R:C276	10.0465	2.69	No	No	0	4	9
21	R:R:C276	R:R:C51	10.9497	7.28	No	No	0	9	9
22	R:R:C51	R:R:Q279	11.8513	1.53	No	No	0	9	8
23	L:L:D77	L:L:P78	20.5501	6.44	Yes	No	0	8	9
24	L:L:P78	L:L:V64	27.39	1.77	No	No	0	9	8
25	L:L:F66	L:L:V64	30.7601	9.18	Yes	No	8	8	8
26	L:L:F66	L:L:L48	27.3545	3.65	Yes	No	0	8	7
27	L:L:L48	L:L:T68	29.0481	4.42	No	No	0	7	9
28	L:L:L70	L:L:T68	30.7256	4.42	No	No	7	5	9
29	L:L:L70	L:L:R47	34.1261	8.5	No	No	0	5	3
30	L:L:K69	L:L:R47	68.2008	6.19	No	No	0	5	3
31	L:L:E49	L:L:K69	34.9535	4.05	No	No	0	1	5
32	L:L:E49	L:L:K67	35.7353	9.45	No	Yes	9	1	4
33	L:L:E73	L:L:K67	73.0992	12.15	No	Yes	0	3	4
34	L:L:E73	L:L:R52	73.876	15.12	No	No	0	3	4
35	L:L:I65	L:L:R52	74.651	10.02	No	No	0	8	4
36	L:L:C75	L:L:I65	75.0576	1.64	No	No	0	9	8
37	L:L:F66	L:L:F86	27.3368	2.14	Yes	No	0	8	4
38	L:L:F86	L:L:I43	29.0253	8.79	No	No	0	4	7
39	L:L:I43	L:L:P44	30.7214	5.08	No	No	0	7	8
40	L:L:P44	L:L:R47	32.4149	4.32	No	No	0	8	3
41	L:L:D71	L:L:K69	34.9189	1.38	No	No	0	5	5
42	L:L:D71	L:L:K67	35.7362	1.38	No	Yes	0	5	4
43	L:L:F66	L:L:Y51	20.5138	12.38	Yes	Yes	8	8	8
44	L:L:M87	L:L:Y51	10.2868	4.79	No	Yes	0	5	8
45	R:R:F109	R:R:W136	22.0513	21.05	Yes	Yes	1	8	8
46	R:R:F109	R:R:H296	12.3692	10.18	Yes	Yes	1	8	9
47	R:R:W136	R:R:W253	17.5425	2.81	Yes	Yes	1	8	9
48	R:R:H296	R:R:W253	22.2318	11.64	Yes	Yes	1	9	9
49	R:R:H256	R:R:W253	15.709	8.46	Yes	Yes	1	8	9
50	R:R:F109	R:R:S139	14.0838	2.64	Yes	No	0	8	8
51	R:R:L108	R:R:S139	15.0899	1.5	No	No	0	8	8
52	R:R:L108	R:R:W174	14.6817	2.28	No	Yes	0	8	9
53	R:R:Q101	R:R:W174	11.6261	2.19	Yes	Yes	11	9	9
54	R:R:W249	R:R:W253	25.8913	15.93	Yes	Yes	1	9	9
55	R:R:F250	R:R:W249	15.2915	11.02	Yes	Yes	1	8	9
56	R:R:C214	R:R:F218	19.9555	4.19	Yes	Yes	1	6	9
57	R:R:A144	R:R:I217	11.4979	1.62	No	No	1	9	5
58	R:R:F250	R:R:L221	20.1284	2.44	Yes	Yes	1	8	8
59	R:R:L221	R:R:L225	15.7048	2.77	Yes	Yes	1	8	8
60	R:R:F252	R:R:H296	18.8245	3.39	Yes	Yes	0	9	9
61	R:R:F252	R:R:L292	12.2359	4.87	Yes	No	0	9	8
62	R:R:L292	R:R:P255	11.1319	4.93	No	No	0	8	8
63	R:R:C214	R:R:H210	29.1535	7.37	Yes	Yes	1	6	9
64	R:R:F218	R:R:W253	15.7832	13.03	Yes	Yes	1	9	9
65	R:R:A144	R:R:F250	10.695	2.77	No	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:T32	R:R:S53	7.99	0	No	No	4	9	0	1
L:L:T33	R:R:P50	1.75	2	No	Yes	4	9	0	1
L:L:T33	R:R:H52	9.58	2	No	No	4	7	0	1
L:L:C34	R:R:Q279	7.63	5	No	No	9	8	0	1
L:L:C35	R:R:P50	1.88	2	No	Yes	9	9	0	1
L:L:Y36	R:R:C276	2.69	0	No	No	4	9	0	1
L:L:I39	R:R:A48	1.62	0	No	No	4	7	0	1
L:L:K41	R:R:E46	5.4	0	No	No	5	3	0	1
L:L:S57	R:R:R267	3.95	1	No	Yes	7	6	0	1
L:L:H58	R:R:D263	3.78	1	Yes	No	4	9	0	1
L:L:H58	R:R:R267	9.03	1	Yes	Yes	4	6	0	1
L:L:P60	R:R:L273	4.93	5	No	No	4	5	0	1
L:L:I65	R:R:P50	1.69	0	No	Yes	8	9	0	1
L:L:I74	R:R:A48	1.62	0	No	No	6	7	0	1
R:R:A49	R:R:P50	1.87	0	No	Yes	8	9	2	1
R:R:H52	R:R:P50	3.05	2	No	Yes	7	9	1	1
R:R:C276	R:R:C51	7.28	0	No	No	9	9	1	2
R:R:N55	R:R:S53	7.45	0	No	No	3	9	2	1
R:R:D283	R:R:S53	4.42	0	No	No	9	9	2	1
R:R:D263	R:R:Y199	8.05	1	No	No	9	5	1	2
R:R:R267	R:R:Y199	23.66	1	Yes	No	6	5	1	2
R:R:D263	R:R:R267	7.15	1	No	Yes	9	6	1	1
R:R:L282	R:R:V266	2.98	0	No	No	8	8	2	1
R:R:L273	R:R:Q279	5.32	0	No	No	5	8	1	1
R:R:C51	R:R:Q279	1.53	0	No	No	9	8	2	1
R:R:L273	R:R:V266	1.49	0	No	No	5	8	1	1
L:L:H58	R:R:V266	1.38	1	Yes	No	4	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
42.86	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
40.00	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
40.00	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
40.00	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
40.00	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
40.00	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
36.36	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
35.71	Single	6LFM	CXCL8	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
35.71	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
35.71	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
35.29	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
33.33	Single	4BV0	Neurotensin-(7-13)	4BV0-NTS₁-Neurotensin-(7-13)
33.33	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
33.33	Single	6LFO	CXCL8	6LFO-CXCR2-CXCL8-Gi1/β1/γ2
33.33	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
33.33	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
33.33	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
33.33	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
33.33	Single	8YNF	CXCL8	8YNF-ACKR1-CXCL8
33.33	Single	9JCL	ADP	9JCL-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
33.33	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
31.58	Single	7F1Q	CCL3	7F1Q-CCR5-CCL3-Gi1/β1/γ2
31.58	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
31.25	Single	4XEE	Neurotensin-(8-13)	4XEE-NTS₁-Neurotensin-(8-13)
31.25	Single	4XES	Neurotensin-(8-13)	4XES-NTS₁-Neurotensin-(8-13)
31.25	Single	6YVR	Neurotensin-(6-13)	6YVR-NTS₁-Neurotensin-(6-13)
31.25	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
30.77	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
30.77	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
30.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
29.41	Single	6UP7	Neurotensin-(8-13)	6UP7-NTS₁-Neurotensin-(8-13)-Arrestin2
29.41	Single	8JPF	Neurotensin-(8-13)	8JPF-NTS₁-Neurotensin-(8-13)-SBI-553
29.41	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
29.41	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
29.41	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
29.41	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
29.41	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
28.57	Single	5T04	Neurotensin-(8-13)	5T04-NTS₁-Neurotensin-(8-13)
28.57	Single	6Z4V	Neurotensin-(9-13)	6Z4V-NTS₁-Neurotensin-(9-13)
28.57	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
28.57	Single	8IC0	CXCL8	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
28.57	Single	9MET	Gp120; CD4	9MET-CXCR4-Gp120; CD4
28.57	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
27.78	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
27.78	Single	8XQJ	JN241	8XQJ-Apelin; Apelin-JN241
27.27	Single	6PWC	Neurotensin-(9-13)	6PWC-NTS₁-Neurotensin-(9-13)-Arrestin2
26.67	Single	8ZYT	Neurotensin-(8-13)	8ZYT-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
26.67	Single	9KO4	CCL21	9KO4-CCR7-CCL21-Gi1/β1/γ2
26.32	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
25.00	Single	3ZEV	Neurotensin-(7-13)	3ZEV-NTS₁-Neurotensin-(7-13)
25.00	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
25.00	Single	6OS1	TRV026	6OS1-AT₁-TRV026
25.00	Single	7L0P	Neurotensin-(8-13)	7L0P-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
25.00	Single	7L0Q	Neurotensin-(8-13)	7L0Q-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
25.00	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
25.00	Single	8FMZ	Neurotensin-(8-13)	8FMZ-NTS₁-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00	Single	8FN1	Neurotensin-(8-13)	8FN1-NTS₁-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
25.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
25.00	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
25.00	Single	8ZYU	Neurotensin-(8-13)	8ZYU-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
25.00	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00	Single	9L16	CCL21	9L16-CCR7-CCL21
25.00	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
25.00	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
25.00	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
25.00	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
24.00	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
23.81	Single	9MEU	CXCL12	9MEU-CXCR4-CXCL12
23.53	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
23.53	Single	7L0S	Neurotensin-(8-13)	7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
23.53	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
23.53	Single	8XQJ	JN241	8XQJ-Apelin; Apelin-JN241
23.53	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
23.53	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
23.53	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
23.53	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
23.53	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
23.08	Single	4BWB	Neurotensin-(8-12)	4BWB-NTS₁-Neurotensin-(8-12)
23.08	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
23.08	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
23.08	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Gi1/β1/γ2
23.08	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
23.08	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
22.73	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
22.73	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
22.73	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
22.22	Single	4BUO	Neurotensin-(8-13)	4BUO-NTS₁-Neurotensin-(8-13)
22.22	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
22.22	Single	8FN0	Neurotensin-(8-13)	8FN0-NTS₁-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
21.74	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
21.74	Single	7F9Y	Ghrelin	7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
21.74	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
21.43	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
21.43	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.43	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
21.43	Single	7UTZ	DPPC	7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
21.43	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100
21.43	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
21.43	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
21.43	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
21.05	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
21.05	Single	9KX6	C5a-des-Arg	9KX6-C5a₁-C5a-des-Arg-Go/β1/γ2
21.05	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
21.05	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.83	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
20.83	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
20.83	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
20.83	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
20.00	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
20.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7L0R	Neurotensin-(8-13)	7L0R-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
20.00	Single	7NA7	Ghrelin	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
20.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
20.00	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00	Single	8ZYY	Neurotensin-(8-13)	8ZYY-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
20.00	Single	9MEJ	Gp120	9MEJ-CXCR4-Gp120
20.00	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
20.00	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
20.00	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
19.23	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
19.23	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
19.23	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.23	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
19.23	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
19.23	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
19.23	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
19.05	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
19.05	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
19.05	Single	8JZZ	C5a-des-Arg	8JZZ-C5a₁-C5a-des-Arg-Go/β1/γ2
19.05	Single	8Z7J	JN241-9	8Z7J-Apelin-JN241-9-Gi1/β1/γ2
19.05	Single	9ME1	CXCL12	9ME1-CXCR4-CXCL12
19.05	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
18.75	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
18.75	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
18.75	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
18.75	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
18.52	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
18.52	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
18.52	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
18.18	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
18.18	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
18.18	Single	8K6N	Neuropeptide-Y	8K6N-Y₂-Neuropeptide-Y-Gi2/β1/γ1
18.18	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
18.18	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
18.18	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.18	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
17.86	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
17.65	Single	5V56	TC114	5V56-SMO-TC114
17.65	Single	5V57	TC114	5V57-SMO-TC114
17.65	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
17.65	Single	7F1T	CCL3	7F1T-CCR5-CCL3
17.65	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
17.65	Single	9MEN	Gp120 (V3 loop)	9MEN-CXCR4-Gp120 (V3 loop)
17.39	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
16.67	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
16.67	Single	6OS2	TRV026	6OS2-AT₁-TRV026
16.67	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
16.67	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
16.67	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67	Single	8T3Q	Doconexent	8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67	Single	9ECJ	S-geranylgeranyl-L-glutathione	9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
16.67	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
16.67	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
16.67	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
16.00	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
16.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
16.00	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
16.00	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
15.79	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116
15.79	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.79	Single	9UYH	Chemerin-9	9UYH-CML2-Chemerin-9-Arrestin2
15.79	Single	9UYM	Chemerin-9	9UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
15.38	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.38	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
15.38	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
15.38	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
15.38	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
15.00	Single	5VBL	AMG3054	5VBL-Apelin-AMG3054
15.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs/β1/γ2
15.00	Single	8Z74	JN241-9	8Z74-Apelin; Apelin-JN241-9
15.00	Single	8Z74	JN241-9	8Z74-Apelin; Apelin-JN241-9
14.81	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
14.29	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
14.29	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
14.29	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
14.29	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
14.29	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
14.29	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
14.29	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
14.29	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
14.29	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
14.29	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
14.29	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
14.29	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
14.29	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
14.29	Single	7DD5	Ca	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
14.29	Single	7DTT	Ca	7DTT-CaS; CaS-Ca-Ca
14.29	Single	7DTT	Ca	7DTT-CaS; CaS-Ca-Ca
14.29	Single	7DTU	Tryptophan	7DTU-CaS; CaS-Tryptophan
14.29	Single	7DTU	Tryptophan	7DTU-CaS; CaS-Tryptophan
14.29	Single	7DTV	Ca	7DTV-CaS; CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca; Tryptophan	7DTV-CaS; CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca	7DTV-CaS; CaS-Ca-Ca; Tryptophan
14.29	Single	7DTV	Ca; Tryptophan	7DTV-CaS; CaS-Ca-Ca; Tryptophan
14.29	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E6T	Ca	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
14.29	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
14.29	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
14.29	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
14.29	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
14.29	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
14.29	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
14.29	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
14.29	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
14.29	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
14.29	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
14.29	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
14.29	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet	7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
14.29	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet	7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
14.29	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
14.29	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
14.29	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
14.29	Single	7SIL	Ca	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
14.29	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
14.29	Single	7SIL	Ca	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
14.29	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
14.29	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7SIM	Ca	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
14.29	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
14.29	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
14.29	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
14.29	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
14.29	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
14.29	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
14.29	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
14.29	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
14.29	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
14.29	Single	7XW7	K1-70	7XW7-TSH-K1-70
14.29	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
14.29	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
14.29	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
14.29	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
14.29	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
14.29	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
14.29	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
14.29	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
14.29	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
14.29	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
14.29	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
14.29	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
14.29	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
14.29	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
14.29	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
14.29	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
14.29	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
14.29	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
14.29	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
14.29	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
14.29	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
14.29	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
14.29	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
14.29	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
14.29	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
14.29	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
14.29	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
14.29	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
14.29	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
14.29	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
14.29	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
14.29	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
14.29	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29	Single	8TQB	Ca; LY379268	8TQB-mGlu3; mGlu3-Ca; LY379268-Ca
14.29	Single	8TQB	Ca; LY379268	8TQB-mGlu3; mGlu3-Ca; LY379268-Ca
14.29	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
14.29	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
14.29	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
14.29	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
14.29	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
14.29	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
14.29	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
14.29	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
14.29	Single	8WG9	PubChem 179394	8WG9-mGlu4; mGlu2-PubChem 179394
14.29	Single	8WGB	Glutamate	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
14.29	Single	8WGB	Glutamate	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
14.29	Single	8WGC	LY379268	8WGC-mGlu2; mGlu4-LY379268
14.29	Single	8WGD	LY341495; CPPG	8WGD-mGlu4; mGlu2-LY341495; CPPG
14.29	Single	8WGD	LY341495; CPPG	8WGD-mGlu4; mGlu2-LY341495; CPPG
14.29	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8WVX	Norrin	8WVX-LGR4-Norrin
14.29	Single	8WVY	Norrin	8WVY-LGR4-Norrin
14.29	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU29
14.29	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU29
14.29	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
14.29	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
14.29	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
14.29	Single	9ASB	Ca	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AVG	Ca	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
14.29	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
14.29	Single	9AVL	Ca	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
14.29	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
14.29	Single	9AVL	Ca	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
14.29	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
14.29	Single	9AXF	Ca	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AXF	Ca	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Single	9AYF	Ca	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
14.29	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
14.29	Single	9C1P	Ca	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C1P	Ca	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29	Single	9C2F	Ca	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9C2F	Ca	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
14.29	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
14.29	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
14.29	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
14.29	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
14.29	Single	9KB7	R-spondin-2	9KB7-LGR4-R-spondin-2
14.29	Single	9KGK	NB18	9KGK-LGR4-NB18
14.29	Single	9KHH	Norrin	9KHH-LGR4-Norrin
14.29	Single	9KO2	CCL19	9KO2-CCR7-CCL19-Gi1/β1
14.29	Single	9KO6	CCL19	9KO6-CCR7-CCL19
14.29	Single	9L3Y	Chemerin	9L3Y-CML2-Chemerin-Gi1/β1/γ2
14.29	Single	9MBA	Glutamate	9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
14.29	Single	9MBA	Glutamate	9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
14.29	Single	9MBB	LY341495	9MBB-mGlu8; mGlu8-LY341495
14.29	Single	9MBB	LY341495	9MBB-mGlu8; mGlu8-LY341495
14.29	Single	9MBC	DCPG	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
14.29	Single	9MBC	DCPG	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
14.29	Single	9S37	NB21	9S37-LGR4-NB21
14.29	Single	9S38	NB21	9S38-LGR4-NB21
14.29	Single	9UMR	C5a-pep	9UMR-C5a₁-C5a-pep-Go/β1/γ2
14.29	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
14.29	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
14.29	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
14.29	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
14.29	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
14.29	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
14.29	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
13.79	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
13.79	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
13.64	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
13.64	Single	6DO1	(Sar1,Ile8)-Angiotensin II	6DO1-AT₁-(Sar1,Ile8)-Angiotensin II
13.64	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
13.64	Single	9KV6	TLQP21	9KV6-C3a_B-TLQP21-Go/β1/γ2
13.64	Single	9UMX	EP54	9UMX-C5a₁-EP54-Go/β1/γ2
13.33	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
13.33	Single	7T94	LY2119620	7T94-M₂-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
13.33	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
13.33	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33	Single	9M2F	Neuropeptide-FF	9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
13.33	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.04	Single	8XZG	Apelin-13	8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
13.04	Single	8XZH	MM07	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
13.04	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
13.04	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Single	9UYI	Chemerin-9	9UYI-CML2-Chemerin-9-Arrestin2
13.04	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
13.04	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
13.04	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
12.90	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
12.50	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
12.50	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
12.50	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
12.50	Single	7DD6	Ca	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
12.50	Single	7DD7	Ca	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7F6G	(Sar1)-Angiotensin II	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
12.50	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
12.50	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
12.50	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
12.50	Single	9ASB	Ca	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	9AVG	Ca	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
12.50	Single	9AYF	Ca	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
12.50	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
12.50	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
12.50	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
12.50	Consensus	cck_off	Orthosteric Ligand	ccka_off
12.50	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
12.50	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.50	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
12.50	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
12.50	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
12.50	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
12.50	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
12.50	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
12.00	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
12.00	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
12.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
12.00	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.00	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00	Single	9JFY	Neuropeptide-SF	9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
12.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
11.76	Single	5N2R	PSB36	5N2R-A_2A-PSB36-Na
11.76	Single	5N2S	PSB36	5N2S-A₁-PSB36
11.76	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
11.76	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.76	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
11.76	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.76	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
11.54	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
11.54	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
11.54	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
11.54	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.54	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
11.54	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
11.54	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
11.54	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
11.11	Single	7EIB	Kallidin-des-Arg10	7EIB-BK₁-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
11.11	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
11.11	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
11.11	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
11.11	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
11.11	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	7XOW	Sulfated Gastrin-(10-17)	7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
11.11	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
11.11	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
11.11	Single	8HQC	C5a	8HQC-C5a₁-C5a-Go/β1/γ2
11.11	Single	8I2G	PubChem 67530240	8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
11.11	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
11.11	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
11.11	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
11.11	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
11.11	Single	9KDF	RES-701-3	9KDF-ET_B-RES-701-3
11.11	Single	9YDV	MRS2905	9YDV-P2Y₁₄-MRS2905-Gi1/β1/γ2
11.11	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
11.11	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
11.11	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
11.11	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
11.11	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
10.71	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
10.53	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
10.53	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
10.53	Single	6OS0	Angiotensin II	6OS0-AT₁-Angiotensin II
10.53	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
10.53	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.53	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
10.53	Single	8DWC	BAM8-22	8DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
10.53	Single	8JJP	Chemerin-9	8JJP-CML2-Chemerin-9-Gi1/β1/γ2
10.53	Single	8U26	Substance-P	8U26-NK₁-Substance-P-Gs/β1/γ2
10.53	Single	9L3W	Chemerin	9L3W-CML1-Chemerin-Gi1/β1/γ2
10.53	Single	9VIF	Neuropeptide-VF	9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
10.53	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
10.53	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
10.53	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
10.53	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.53	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Consensus	orexin_on	Orthosteric Ligand	ox2_on
10.53	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	7EZC	UK-432097	7EZC-A_2A-UK-432097
10.00	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
10.00	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
10.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
10.00	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	7UTZ	TSH	7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
10.00	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
10.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
10.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
10.00	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00	Single	7Y65	C5a (C-terminal peptide)	7Y65-C5a₁-C5a (C-terminal peptide)-Gi1/β1/γ2
10.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
10.00	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
10.00	Single	9J0B	UDP-Glucose	9J0B-P2Y₁₄-UDP-Glucose-Gi1/β1/γ2
10.00	Single	9JH5	C16:0 Ceramide	9JH5-CysLT₂-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
10.00	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
10.00	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
10.00	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
10.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
10.00	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
10.00	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
10.00	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
10.00	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
9.52	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
9.52	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.52	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
9.52	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
9.52	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
9.52	Single	7XN9	L-054522	7XN9-SST2-L-054522
9.52	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
9.52	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
9.52	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8SAI	Lysophosphatidylserine (S12)	8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
9.52	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
9.52	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	9UMJ	EP54	9UMJ-C3a_B-EP54-Go/β1/γ2
9.52	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
9.52	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
9.52	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
9.52	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.52	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.09	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
9.09	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
9.09	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
9.09	Single	7V68	LY2119620	7V68-M₄-Iperoxo-LY2119620-Gi1/β1/γ2
9.09	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
9.09	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
9.09	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
9.09	Single	8DWG	BAM8-22	8DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09	Single	8I2G	FSH	8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
9.09	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
9.09	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8ZBJ	Somatostatin-14	8ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
9.09	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
9.09	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9HB3	Mambaquaretin-1	9HB3-V₂-Mambaquaretin-1
9.09	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
9.09	Single	9UYJ	Chemerin-9	9UYJ-CML2-Chemerin-9-Arrestin2
9.09	Single	9UYL	Chemerin-9	9UYL-CML2-Chemerin-9-Arrestin2
9.09	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
9.09	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
9.09	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.09	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.09	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
9.09	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
9.09	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
9.09	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
8.82	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.82	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
8.70	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
8.70	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
8.70	Single	7PIV	Afamelanotide	7PIV-MC₄-Afamelanotide-Gs/β1/γ2
8.70	Single	7VBI	Tirzepatide (non-acylated)	7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
8.70	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
8.70	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
8.70	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
8.70	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
8.70	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
8.70	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8K6O	Neuropeptide-Y	8K6O-Y₁-Neuropeptide-Y-Gi2/β1/γ1
8.70	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.70	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
8.70	Single	8WSS	MCH	8WSS-MCH1-MCH-Gi1/β1/γ1
8.70	Single	9E82	CXCL12 (fragment)	9E82-ACKR3-CXCL12 (fragment)-Arrestin2
8.70	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
8.70	Single	9J0F	NADH	9J0F-P2Y₁₄-NADH-Gi1/β1/γ2
8.70	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
8.70	Single	9L60	Dynorphin	9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
8.70	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
8.70	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.70	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
8.70	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
8.70	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
8.70	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
8.70	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
8.70	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
8.70	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
8.70	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
8.70	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
8.33	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
8.33	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
8.33	Single	6MEO	Gp160; CD4	6MEO-CCR5-Gp160; CD4
8.33	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
8.33	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
8.33	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
8.33	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
8.33	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
8.33	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
8.33	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
8.33	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8YFO	Ac-LA-PTH Analog	8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
8.33	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
8.33	Single	9LXR	LA-PTH Analog	9LXR-PTH1-LA-PTH Analog-Arrestin2
8.33	Single	9M1O	Neuropeptide-FF	9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
8.33	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
8.33	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
8.33	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
8.33	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
8.33	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
8.00	Single	6MET	Gp160; CD4	6MET-CCR5-Gp160; CD4
8.00	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
8.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
8.00	Single	8XZJ	WN353	8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
8.00	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
8.00	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
8.00	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
8.00	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
8.00	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
8.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
8.00	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
8.00	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
7.69	Single	5YQZ	NNC1702	5YQZ-Glucagon-NNC1702
7.69	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
7.69	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.69	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
7.69	Single	7P02	Substance-P	7P02-NK₁-Substance-P-chim(NtGi1-Gs)/β1/γ2
7.69	Single	7TYH	Calcitonin	7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
7.69	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.69	Single	7Y64	C5a	7Y64-C5a₁-C5a-Gi1/β1/γ2
7.69	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
7.69	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
7.69	Single	8HK5	C5a	8HK5-C5a₁-C5a-Gi1/β1/γ2
7.69	Single	8J6Q	PubChem 25101223	8J6Q-HCA₂-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
7.69	Single	8JEF	PubChem 11367166	8JEF-HCA₃-PubChem 11367166-Gi1/β1/γ2
7.69	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
7.69	Single	8XQE	Apelin-13	8XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
7.69	Single	8YG4	LA-PTH Analog	8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8ZRT	Endothelin-1	8ZRT-ET_B-Endothelin-1
7.69	Single	9E2A	GLP-1	9E2A-GLP-1-GLP-1-Gs/β1/γ2
7.69	Single	9IJR	C17	9IJR-GPR52-C17-Arrestin2
7.69	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
7.69	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
7.69	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.69	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
7.69	Consensus	pac_on	Orthosteric Ligand	pac1_on
7.50	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.41	Single	6FJ3	PTH	6FJ3-PTH1-PTH
7.41	Single	6NBF	LA-PTH Analog	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
7.41	Single	6NBI	LA-PTH Analog	6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
7.41	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
7.41	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
7.41	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
7.41	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
7.41	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.41	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
7.41	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
7.41	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
7.41	Single	9BLB	Cagrilintide (non-acylated)	9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
7.41	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
7.41	Single	9P92	VIP	9P92-PAC₁-VIP-Gs/β1/γ2
7.41	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
7.41	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
7.41	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
7.41	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
7.41	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
7.14	Single	6LI0	C17	6LI0-GPR52-C17
7.14	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.14	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
7.14	Single	7S1M	Exendin-4-D-Ala	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
7.14	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
7.14	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
7.14	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
7.14	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
7.14	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
7.14	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
7.14	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
7.14	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.14	Single	8J6P	PubChem 25101223	8J6P-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
7.14	Single	8JHY	PubChem 25101223	8JHY-HCA₂-PubChem 25101223-Gi1/β1/γ2
7.14	Single	8JII	PubChem 25101223	8JII-HCA₂-Niacin-PubChem 25101223-Gi1/β1/γ2
7.14	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
7.14	Single	8W8X	Beta-MSH	8W8X-MC₃-β-MSH-Ca-Gs/β1/γ2
7.14	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
7.14	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
7.14	Single	9B9Y	Taranabant	9B9Y-CB₁-Taranabant
7.14	Single	9JLC	AVE 0991	9JLC-MAS1-AVE 0991-Gi1/β1/γ2
7.14	Single	9KUW	CMPD644	9KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
7.14	Single	9MBC	AZ12216052	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
7.14	Single	9MNI	dC2_05	9MNI-CTLike-dC2_05-RAMP1
7.14	Single	9P94	PACAP27	9P94-PAC₁-PACAP27-Gs/β1/γ2
7.14	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
7.14	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.90	Single	6NBH	LA-PTH Analog	6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
6.90	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
6.90	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
6.90	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
6.90	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.90	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
6.90	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.90	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.90	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.90	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
6.90	Single	9P93	VIP	9P93-PAC₁-VIP-Gs/β1/γ2
6.90	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.90	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
6.90	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
6.67	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
6.67	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
6.67	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
6.67	Single	5U09	Taranabant	5U09-CB₁-Taranabant
6.67	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
6.67	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
6.67	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
6.67	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
6.67	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
6.67	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
6.67	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
6.67	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
6.67	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.67	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
6.67	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
6.67	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
6.67	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
6.67	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
6.67	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
6.67	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
6.67	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
6.67	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
6.67	Single	8ZJE	TAK448	8ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
6.67	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
6.67	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
6.45	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
6.45	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
6.45	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.45	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
6.45	Single	8FLU	LA-PTH Analog	8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
6.45	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
6.25	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
6.25	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
6.25	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
6.25	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
6.25	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
6.25	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
6.25	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
6.25	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
6.25	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
6.25	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
6.25	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
6.25	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
6.25	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
6.25	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
6.25	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
6.25	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
6.25	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
6.25	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
6.25	Single	8K4N	PubChem 168719765	8K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
6.25	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
6.25	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
6.25	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
6.25	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
6.25	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	9BA0	MRI-1891	9BA0-CB₁-MRI-1891
6.25	Single	9JH3	CMF-019	9JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
6.25	Single	9JMD	Azithromycin	9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.25	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25	Single	9KPD	Salicin	9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
6.25	Single	9KUW	CMPD644	9KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
6.25	Single	9P1T	ZM-241385	9P1T-A_2A-ZM-241385
6.25	Consensus	a2_off	Orthosteric Ligand	a2a_off
6.25	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA47070-Na 5N2R-A_2A-PSB36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-Etrumadenant-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-PubChem 984073-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
6.25	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
6.25	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
6.25	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
6.25	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.06	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
6.06	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.06	Single	7Y36	PTH	7Y36-PTH1-PTH-Gs/β1/γ2
6.06	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
6.06	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
5.88	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
5.88	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
5.88	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.88	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
5.88	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
5.88	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
5.88	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
5.88	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
5.88	Single	6D27	CAY10471	6D27-DP₂-CAY10471
5.88	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.88	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
5.88	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
5.88	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
5.88	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
5.88	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
5.88	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
5.88	Single	7NA8	Ibutamoren	7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
5.88	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
5.88	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
5.88	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
5.88	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
5.88	Single	7VIF	FTY720-P	7VIF-S1P₁-FTY720-P-Gi1/β1/γ2
5.88	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
5.88	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
5.88	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
5.88	Single	8XBG	S3E-Lysophosphatidylserine	8XBG-GPR34-S3E-Lysophosphatidylserine
5.88	Single	8Y71	A1D6F	8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
5.88	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
5.88	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
5.88	Single	9IMA	Talquetamab	9IMA-GPRC5D; GPRC5D-Talquetamab
5.88	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9KFT	fMLFC	9KFT-FPR1-ALX-fMLFC-Gi1/β1/γ2
5.88	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
5.88	Single	9P1S	ZM-241385	9P1S-A_2A-ZM-241385
5.88	Consensus	a3_on	Orthosteric Ligand	a3a_on
5.88	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.88	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.88	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.88	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.71	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.56	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.56	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
5.56	Single	5C1M	BU72	5C1M-μ-BU72
5.56	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
5.56	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
5.56	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
5.56	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
5.56	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
5.56	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
5.56	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
5.56	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.56	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
5.56	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
5.56	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
5.56	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
5.56	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
5.56	Single	7VFX	fMIFL	7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
5.56	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
5.56	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
5.56	Single	7WIG	L-054264	7WIG-SST2-L-054264-Gi1/β1/γ2
5.56	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
5.56	Single	8IZ4	Lysophosphatidylserine (TJR)	8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
5.56	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
5.56	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
5.56	Single	9B9Z	MRI-1867	9B9Z-CB₁-MRI-1867
5.56	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
5.56	Single	9KPF	Salicin	9KPF-TAS2R16-Salicin-Gi1/β1/γ2
5.56	Single	9KUV	CMPD644	9KUV-Apelin-CMPD644-Arrestin2
5.56	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
5.56	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
5.56	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.56	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.56	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
5.56	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
5.56	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
5.56	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
5.56	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.56	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
5.56	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
5.56	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
5.41	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
5.26	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
5.26	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
5.26	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
5.26	Single	6DDE	DAMGO	6DDE-μ-DAMGO-Gi1/β1/γ2
5.26	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
5.26	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.26	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
5.26	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
5.26	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
5.26	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
5.26	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
5.26	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.26	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
5.26	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
5.26	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
5.26	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
5.26	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
5.26	Single	8I9L	C3a	8I9L-C3a_B-C3a-Go/β1/γ2
5.26	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8JZP	C5a	8JZP-C5a₁-C5a-Go/β1/γ2
5.26	Single	8UGW	CGS21680	8UGW-A_2A-CGS21680
5.26	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
5.26	Single	8XBI	PubChem 162656636	8XBI-GPR34-PubChem 162656636
5.26	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26	Single	8XZI	CMF-019	8XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
5.26	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
5.26	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
5.26	Single	9IK9	Lanreotide	9IK9-SST1-Lanreotide-Gi1/β1/γ2
5.26	Single	9IZG	LPA	9IZG-LPA₁-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9JMC	DS-3801b	9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
5.26	Single	9KUX	CMPD644	9KUX-Apelin; Apelin-CMPD644-Arrestin2
5.26	Single	9UY3	Anamorelin	9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
5.26	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.26	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.26	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
5.26	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
5.26	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
5.26	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
5.26	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
5.26	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
5.26	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.26	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
5.00	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
5.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
5.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
5.00	Single	7EW2	FTY720-P	7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
5.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
5.00	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
5.00	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
5.00	Single	7W0L	PubChem 122701908	7W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
5.00	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
5.00	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Single	8HK2	C3a	8HK2-C3a_B-C3a-Gi1/β1/γ2
5.00	Single	8ID9	Icosapent	8ID9-FFA4-Icosapent-Gi1/β1/γ2
5.00	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
5.00	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
5.00	Single	9WXM	GPR15L(CT)	9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
5.00	Single	9YDQ	DADLE	9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
5.00	Single	9YDU	UDP-Glucose	9YDU-P2Y₁₄-UDP-Glucose-Gi1/β1/γ2
5.00	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.00	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
5.00	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
5.00	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.00	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
5.00	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
5.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
5.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
5.00	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
5.00	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.00	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
5.00	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
5.00	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
5.00	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.00	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
5.00	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
4.76	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.76	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.76	Single	6DDF	DAMGO	6DDF-μ-DAMGO-Gi1/β1/γ2
4.76	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
4.76	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.76	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
4.76	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
4.76	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
4.76	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
4.76	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.76	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
4.76	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
4.76	Single	8E0G	BU72	8E0G-μ-BU72
4.76	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.76	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
4.76	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	8XBE	S3E-Lysophosphatidylserine	8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
4.76	Single	8XGS	Kisspeptin-1	8XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
4.76	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
4.76	Single	9CGJ	C6-Quino	9CGJ-δ-C6-Quino-Gi1/β1/γ2
4.76	Single	9IZF	LPA	9IZF-LPA₁-LPA-Gi1/β1/γ2
4.76	Single	9KUG	EP67	9KUG-C5a₁-EP67-Go/β1/γ2
4.76	Single	9KWX	C5a-des-Arg	9KWX-C5a₁-C5a-des-Arg-Go/β1/γ2
4.76	Single	9VI9	RFRP-3	9VI9-NPFF1-RFRP-3-Gi1/β1/γ2
4.76	Single	9WP9	S1P	9WP9-S1P₃-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	9YDP	DADLE	9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.76	Single	9YDR	DADLE	9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.76	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.76	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
4.76	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.76	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.76	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
4.55	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.55	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
4.55	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.55	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.55	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	7RKF	CX3CL1	7RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
4.55	Single	7RKN	CX3CL1	7RKN-US28-CX3CL1-Gi1/β1/γ2
4.55	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.55	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
4.55	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
4.55	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
4.55	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
4.55	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8XZF	WN561	8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
4.55	Single	9CGK	C5-Quino	9CGK-δ-C5-Quino-Gi1/β1/γ2
4.55	Single	9KZ2	EP67	9KZ2-C3a_B-EP67-Go/β1/γ2
4.55	Single	9KZ8	EP67	9KZ8-C3a_B-EP67-Go/β1/γ2
4.55	Single	9V2N	Macimorelin	9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.55	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
4.55	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
4.55	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
4.55	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
4.35	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
4.35	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
4.35	Single	4XT1	CX3CL1	4XT1-US28-CX3CL1
4.35	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.35	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
4.35	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
4.35	Single	7QA8	Antagonist Peptide	7QA8-STE2; STE2-Antagonist Peptide
4.35	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
4.35	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
4.35	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
4.35	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
4.35	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
4.35	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
4.35	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8IZB	Lysophosphatidylserine (UBL)	8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
4.35	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
4.35	Single	8WKY	PG-934	8WKY-MC₄-PG-934
4.35	Single	8XBH	PubChem 162656636	8XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
4.35	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
4.35	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
4.35	Single	8Y69	R-spondin-2	8Y69-LGR4; LGR4-R-spondin-2-ZNRF3
4.35	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8ZJD	Kisspeptin-1	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
4.35	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
4.35	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
4.35	Single	9KWG	C5a	9KWG-C5a₁-C5a-Go/β1/γ2
4.35	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
4.35	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
4.35	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
4.35	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
4.35	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.35	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
4.35	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
4.35	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
4.17	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
4.17	Single	7RKM	CX3CL1	7RKM-US28-CX3CL1-Gi1/β1/γ2
4.17	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.17	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
4.17	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.17	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
4.17	Single	8IEB	PubChem 134746894	8IEB-GPR156; GPR156-PubChem 134746894
4.17	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
4.17	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
4.17	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
4.17	Single	9IK8	Pasireotide	9IK8-SST1-Pasireotide-Gi1/β1/γ2
4.17	Single	9IQV	Muscarinic toxin 3	9IQV-Alpha1A-Muscarinic toxin 3
4.17	Single	9KB8	R-spondin-2	9KB8-LGR4-R-spondin-2-ZNRF3; ZNRF3
4.17	Single	9KB9	R-spondin-2	9KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
4.17	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
4.17	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
4.17	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.17	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.00	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
4.00	Single	6VN7	PACAP27	6VN7-VPAC₁-PACAP27-Gs/β1/γ2
4.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
4.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
4.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
4.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
4.00	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
4.00	Single	8W8Y	Gamma-MSH	8W8Y-MC₃-γ-MSH-Ca-Gs/β1/γ2
4.00	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
4.00	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
4.00	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00	Single	8Y69	R-spondin-2	8Y69-LGR4; LGR4-R-spondin-2-ZNRF3
4.00	Single	9B5Y	LA-PTH Analog	9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
4.00	Single	9KB9	R-spondin-2	9KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
4.00	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
4.00	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
4.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.00	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.00	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
4.00	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
4.00	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
4.00	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
4.00	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
3.85	Single	6M1I	PACAP27	6M1I-PAC₁-PACAP27-Gs/β1/γ2
3.85	Single	6NIY	Calcitonin-1	6NIY-CT-Calcitonin-1-Gs/β1/γ2
3.85	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
3.85	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.85	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.85	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
3.85	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.85	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
3.85	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.85	Single	8IED	PubChem 134746894	8IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
3.85	Single	8WST	MCH	8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85	Single	8X8L	Cortistatin-14	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.85	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
3.85	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.85	Single	8ZBI	Somatostatin-14	8ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
3.85	Single	9BLC	Cagrilintide (non-acylated)	9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
3.85	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
3.85	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.85	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
3.85	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.85	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.85	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
3.70	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
3.70	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
3.70	Single	7XV3	Lysophosphatidylserine (WJS)	7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8IA2	C5a	8IA2-C5a₁-C5a-Go/β1/γ2
3.70	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
3.70	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
3.70	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.70	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.70	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
3.70	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
3.57	Single	4XT3	CX3CL1	4XT3-US28-CX3CL1
3.57	Single	6P9Y	PACAP27	6P9Y-PAC₁-PACAP27-Gs/β1/γ2
3.57	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.57	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2; STE2-α-factor mating pheromone
3.57	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7VAB	Tirzepatide (non-acylated)	7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
3.57	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	9BLW	Cagrilintide (non-acylated)	9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
3.57	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
3.57	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
3.57	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
3.57	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.57	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
3.45	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.45	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
3.45	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
3.45	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.45	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
3.45	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.45	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.45	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
3.45	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
3.45	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
3.45	Single	8FU6	ZP3780	8FU6-Glucagon-ZP3780-Gs/β1/γ2
3.45	Single	8W8W	Alpha-MSH	8W8W-MC₃-α-MSH-Ca-Gs/β1/γ2
3.45	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
3.45	Single	8ZH8	QRFP26	8ZH8-QRFP-QRFP26-Gq/β1/γ1
3.45	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
3.45	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
3.45	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
3.45	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
3.45	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.45	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
3.45	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.33	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
3.33	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.33	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.33	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
3.33	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
3.33	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
3.33	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2; STE2-α-factor mating pheromone
3.33	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
3.33	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
3.33	Single	8KGG	Lysophosphatidylserine (WJS)	8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
3.33	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
3.33	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
3.33	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
3.33	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
3.23	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.23	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.23	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.23	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.23	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
3.23	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.23	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
3.23	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.12	Single	6LPB	PACAP27	6LPB-PAC₁-PACAP27-Gs/β1/γ1
3.12	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.03	Single	6WPW	ZP3780	6WPW-Glucagon-ZP3780-Gs/β1/γ2
3.03	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.03	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.03	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-1-Gs/β1/γ2
3.03	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
2.94	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.94	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
2.94	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
2.94	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.86	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.70	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
2.70	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2

PDB Summary
PDB	8JPS
Class	A
SubFamily	Protein
Type	Chemokine
SubType	ACKR1
Species	Homo Sapiens
Ligand	CCL7
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.65
Date	2024-07-31
D.O.I.	doi.org/10.1016/j.cell.2024.07.005

Net Summary
I_min	1.58
Number of Linked Nodes	283
Number of Links	355
Number of Hubs	46
Number of Links mediated by Hubs	168
Number of Communities	14
Number of Nodes involved in Communities	98
Number of Links involved in Communities	142

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	164444
Length Of Smallest Path	3
Average Path Length	23.3682
Length of Longest Path	44
Minimum Path Strength	1.38
Average Path Strength	6.00998
Maximum Path Strength	19.155
Minimum Path Correlation	0.7
Average Path Correlation	0.942653
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	45.7396
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.943
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • molecular function activator activity • signaling receptor binding • G protein-coupled receptor binding • signaling receptor activator activity • protein binding • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CCR chemokine receptor binding • CCR1 chemokine receptor binding • CCR2 chemokine receptor binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • regulation of defense response • regulation of biological process • response to stimulus • regulation of response to external stimulus • defense response • biological regulation • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress
Gene Ontology	Biological Process	• regulation of defense response • regulation of biological process • response to stimulus • regulation of response to external stimulus • defense response • biological regulation • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • cellular response to stimulus • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • positive regulation of chemotaxis • positive regulation of cell migration • regulation of lymphocyte chemotaxis • natural killer cell chemotaxis • taxis • positive regulation of natural killer cell chemotaxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • positive regulation of lymphocyte migration • regulation of leukocyte migration • lymphocyte migration • positive regulation of leukocyte chemotaxis • leukocyte migration • response to chemical • regulation of locomotion • regulation of natural killer cell chemotaxis • lymphocyte chemotaxis • regulation of lymphocyte migration • positive regulation of lymphocyte chemotaxis • positive regulation of cell motility • regulation of cell migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • cellular response to chemical stimulus • immune system process • mononuclear cell migration • cellular process • leukocyte chemotaxis • cell surface receptor signaling pathway • signaling • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • cell-cell signaling • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • developmental process • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • anatomical structure development • regulation of biological quality • regulation of anatomical structure morphogenesis • cellular component organization • organelle organization • cellular component organization or biogenesis • cytoskeleton organization • monocyte chemotaxis • myeloid leukocyte migration • response to alcohol • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to alcohol • cellular response to ethanol • response to ethanol • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • immune response • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to external biotic stimulus • response to ionizing radiation • response to radiation • response to abiotic stimulus • response to gamma radiation • eosinophil chemotaxis • granulocyte migration • eosinophil migration • granulocyte chemotaxis • cellular anatomical structure • extracellular region • extracellular space • C-C chemokine binding • protein binding • binding • chemokine binding • cytokine binding • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • membrane-bounded organelle • intracellular anatomical structure • early endosome • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • cytoplasm • vesicle • cell periphery • plasma membrane • membrane • recycling endosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Interleukin 8-like chemokines
SCOP2	Family Identifier	• Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	CCL7
UniProt	P80098
Sequence	>8JPS_Chain_L S T T C C Y R F I N K K I P K Q R L E S Y R R T T S S H C P R E A V I F K T K L D K E I C A D P T Q K W V Q D F M K H L D K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q16570
Sequence	>8JPS_Chain_R E A A A P C H S C N L L D D S A L P F F I L T S V L G I L A S S T V L F M L F R P L F R W Q L C P G W P V L A Q L A V G S A L F S I V V P V L A P G L G S T R S S A L C S L G Y C V W Y G S A F A Q A L L L G C H A S L G H R L G A G Q V P G L T L G L T V G I W G V A A L L T L P V T L A S G A S G G L C T L I Y S T E L K A L Q A T H T V A C L A I F V L L P L G L F G A K G P W M N I L W A W F I F W W P H G V V L G L D F L V R S K L L L L S T C L A Q Q A L D L L L N L A E A L A I L H C V A T P L L L A L F C H Q A T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPS	A	Protein	Chemokine	ACKR1	Homo sapiens	CCL7	-	-	3.65	2024-07-31	doi.org/10.1016/j.cell.2024.07.005
	8YNF	A	Protein	Chemokine	ACKR1	Homo sapiens	CXCL8	-	-	3.65	2025-09-17	To be published

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