Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L26 R:R:V29 5.96 0 No No 0 3 0 1
L:L:I28 R:R:T31 7.6 0 Yes No 0 4 0 1
L:L:N30 R:R:M33 5.61 0 No No 0 2 0 1
R:R:K40 R:R:N36 5.6 0 Yes No 3 4 1 1
L:L:P32 R:R:N36 6.52 0 No No 0 4 0 1
R:R:K40 R:R:M37 7.2 0 Yes No 3 5 1 2
R:R:F294 R:R:K40 14.89 2 Yes Yes 4 3 1 1
L:L:N33 R:R:K40 4.2 0 No Yes 0 3 0 1
R:R:F294 R:R:L43 10.96 2 Yes No 4 4 1 2
R:R:H298 R:R:L43 10.29 2 Yes No 5 4 1 2
R:R:L104 R:R:L47 4.15 0 No Yes 5 6 2 2
R:R:H298 R:R:L47 6.43 2 Yes Yes 5 6 1 2
R:R:T120 R:R:W100 3.64 0 No Yes 5 7 2 1
R:R:F124 R:R:W100 11.02 0 No Yes 7 7 2 1
L:L:H2 R:R:W100 23.27 0 No Yes 0 7 0 1
L:L:L5 R:R:W100 6.83 1 No Yes 0 7 0 1
R:R:S103 R:R:W110 4.94 0 No Yes 6 8 1 2
L:L:S4 R:R:S103 6.52 0 No No 0 6 0 1
R:R:L104 R:R:N108 4.12 0 No No 5 4 2 1
L:L:S4 R:R:N108 5.96 0 No No 0 4 0 1
L:L:Y7 R:R:N108 9.3 0 No No 0 4 0 1
R:R:Q109 R:R:Y195 5.64 0 No No 4 3 2 1
R:R:C117 R:R:W110 13.06 1 No Yes 9 8 2 2
R:R:C117 R:R:L183 6.35 1 No Yes 9 4 2 1
R:R:H121 R:R:S125 5.58 1 Yes No 6 4 1 2
R:R:D179 R:R:H121 6.3 1 Yes Yes 4 6 1 1
R:R:H121 R:R:T180 8.21 1 Yes No 6 4 1 2
R:R:H121 R:R:L183 3.86 1 Yes Yes 6 4 1 1
L:L:L5 R:R:H121 5.14 1 No Yes 0 6 0 1
R:R:F129 R:R:S216 5.28 0 No No 7 5 2 1
R:R:D179 R:R:Y200 6.9 1 Yes Yes 4 5 1 1
R:R:D179 R:R:M212 11.09 1 Yes No 4 4 1 2
L:L:R1 R:R:D179 5.96 1 Yes Yes 0 4 0 1
R:R:Y182 R:R:Y200 7.94 1 Yes Yes 4 5 2 1
R:R:P201 R:R:Y182 13.91 1 No Yes 5 4 2 2
R:R:W208 R:R:Y182 11.58 1 Yes Yes 4 4 2 2
R:R:L183 R:R:S198 4.5 1 Yes No 4 4 1 2
L:L:L5 R:R:L183 4.15 1 No Yes 0 4 0 1
L:L:Y7 R:R:Y195 17.87 0 No No 0 3 0 1
L:L:R12 R:R:R197 4.26 2 Yes No 0 3 0 1
R:R:S198 R:R:Y200 13.99 0 No Yes 4 5 2 1
R:R:F199 R:R:I205 3.77 0 No No 4 2 2 1
R:R:P201 R:R:Y200 4.17 1 No Yes 5 5 2 1
R:R:W208 R:R:Y200 12.54 1 Yes Yes 4 5 2 1
R:R:L209 R:R:Y200 4.69 1 No Yes 2 5 1 1
L:L:R1 R:R:Y200 5.14 1 Yes Yes 0 5 0 1
R:R:P201 R:R:W208 8.11 1 No Yes 5 4 2 2
L:L:F13 R:R:K206 23.58 0 Yes No 0 4 0 1
R:R:M212 R:R:W208 4.65 0 No Yes 4 4 2 2
L:L:R1 R:R:L209 4.86 1 Yes No 0 2 0 1
L:L:L0 R:R:E213 3.98 0 No No 0 4 0 1
L:L:R1 R:R:E213 15.12 1 Yes No 0 4 0 1
L:L:L0 R:R:S216 6.01 0 No No 0 5 0 1
R:R:H269 R:R:Y268 4.36 10 Yes Yes 8 7 2 1
R:R:V272 R:R:Y268 6.31 0 No Yes 5 7 2 1
R:R:T300 R:R:Y268 8.74 0 No Yes 7 7 2 1
R:R:Q301 R:R:Y268 14.65 0 No Yes 6 7 1 1
R:R:S304 R:R:Y268 10.17 0 No Yes 8 7 2 1
L:L:L0 R:R:Y268 8.21 0 No Yes 0 7 0 1
R:R:D275 R:R:I279 4.2 2 Yes Yes 4 4 1 1
R:R:D275 R:R:L297 6.79 2 Yes No 4 5 1 1
L:L:R8 R:R:D275 3.57 2 Yes Yes 0 4 0 1
L:L:R12 R:R:D275 10.72 2 Yes Yes 0 4 0 1
R:R:L293 R:R:S278 6.01 0 No No 4 4 1 2
L:L:R12 R:R:I279 3.76 2 Yes Yes 0 4 0 1
R:R:L280 R:R:Y282 3.52 5 No No 1 1 1 1
L:L:R47 R:R:L280 3.64 5 Yes No 0 1 0 1
R:R:F285 R:R:H281 4.53 0 Yes Yes 2 2 1 1
L:L:K27 R:R:H281 9.17 7 Yes Yes 0 2 0 1
L:L:V39 R:R:H281 13.84 7 No Yes 0 2 0 1
L:L:Q48 R:R:H281 7.42 7 Yes Yes 0 2 0 1
L:L:N45 R:R:Y282 6.98 0 No No 0 1 0 1
L:L:R47 R:R:Y282 10.29 5 Yes No 0 1 0 1
R:R:E290 R:R:F285 10.49 0 No Yes 3 2 1 1
L:L:L29 R:R:F285 17.05 0 No Yes 0 2 0 1
R:R:L289 R:R:L293 5.54 0 No No 1 4 2 1
L:L:R8 R:R:E290 4.65 2 Yes No 0 3 0 1
L:L:R8 R:R:L293 3.64 2 Yes No 0 4 0 1
R:R:F294 R:R:H298 9.05 2 Yes Yes 4 5 1 1
L:L:R8 R:R:F294 7.48 2 Yes Yes 0 4 0 1
L:L:R8 R:R:L297 4.86 2 Yes No 0 5 0 1
L:L:Q3 R:R:H298 3.71 0 No Yes 0 5 0 1
L:L:Q3 R:R:Q301 3.84 0 No No 0 6 0 1
L:L:T31 R:R:C34 3.38 0 No No 0 8 0 1
R:R:M33 R:R:P35 3.35 0 No No 2 4 1 2
L:L:C11 R:R:I279 3.27 0 No Yes 0 4 0 1
L:L:I28 R:R:V29 3.07 0 Yes No 0 3 0 1
L:L:K24 R:R:I27 2.91 0 No No 0 6 0 1
R:R:I210 R:R:K206 2.91 0 No No 2 4 2 1
R:R:K206 R:R:L280 2.82 0 No No 4 1 1 1
L:L:C9 R:R:R197 2.79 2 No No 0 3 0 1
L:L:H25 R:R:V28 2.77 0 No No 0 3 0 1
R:R:F285 R:R:V32 2.62 0 Yes No 2 2 1 2
R:R:R197 R:R:V186 2.62 2 No No 3 1 1 2
L:L:F13 R:R:I205 2.51 0 Yes No 0 2 0 1
L:L:F13 R:R:I279 2.51 0 Yes Yes 0 4 0 1
L:L:A65 R:R:T31 1.68 0 No No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7SK6
Class A
SubFamily Protein
Type Chemokine
SubType ACKR3
Species Homo sapiens
Ligand CXCL12_LRHQ
Other Ligand(s) -
Protein Partners -
PDB Resolution 4
Date 2022-07-27
D.O.I. 10.1126/sciadv.abn8063
Net Summary
Imin 3.5
Number of Linked Nodes 338
Number of Links 384
Number of Hubs 53
Number of Links mediated by Hubs 192
Number of Communities 12
Number of Nodes involved in Communities 67
Number of Links involved in Communities 87
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 118739
Length Of Smallest Path 3
Average Path Length 16.6353
Length of Longest Path 36
Minimum Path Strength 1.425
Average Path Strength 7.09193
Maximum Path Strength 20.145
Minimum Path Correlation 0.7
Average Path Correlation 0.93796
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 47.8245
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.7439
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25106
Sequence
>7SK6_Chain_R
IVVDTVMCP NMPNKSVLL YTLSFIYIF IFVIGMIAN SVVVWVNIQ 
AKTTGYDTH CYILNLAIA DLWVVLTIP VWVVSLVQH NQWPMGELT 
CKVTHLIFS INLFGSIFF LTCMSVDRY LSITYFTNT PSSRKKMVR 
RVVCILVWL LAFCVSLPD TYYLKTVNE TYCRSFYPE HSIKEWLIG 
MELVSVVLG FAVPFSIIA VFYFLLARA ISASSDQEK HSSRKIIFS 
YVVVFLVCW LPYHVAVLL DIFSILHYI PFTCRLEHA LFTALHVTQ 
CLSLVHCCV NPVLYSFIN RNYRYELMK AFI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SK3AProteinChemokineACKR3Homo sapiensCXCL12--3.82022-07-2710.1126/sciadv.abn8063
7SK4AProteinChemokineACKR3Homo sapiensCXCL12_LRHQ--3.32022-07-2710.1126/sciadv.abn8063
7SK5AProteinChemokineACKR3Homo sapiensCXCL12--42022-07-2710.1126/sciadv.abn8063
7SK6AProteinChemokineACKR3Homo sapiensCXCL12_LRHQ--42022-07-2710.1126/sciadv.abn8063
7SK7AProteinChemokineACKR3Homo sapiensCXCL12CCX662-3.32022-07-2710.1126/sciadv.abn8063
7SK8AProteinChemokineACKR3Homo sapiensCXCL12CCX662-3.32022-07-2710.1126/sciadv.abn8063
7SK9AProteinChemokineACKR3Homo sapiens-CCX662-3.72022-07-2710.1126/sciadv.abn8063




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SK6.zip



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