Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x31 2.89414
21x32 2.76583403
31x35 4.69933516
41x39 4.53667507
51x43 4.784174166
61x50 4.3345169
71x57 3.777146
81x60 2.45467505
92x40 2.82583407
102x42 4.375607
112x50 4.995834169
122x53 5.3575407
132x60 4.61517
142x63 3.45542815
152x64 5.09733515
16E1x50 5.1175418
173x22 1.62503
183x29 3.91067515
193x37 3.49267507
203x42 6.193896177
213x43 3.73083408
223x46 4.593334108
233x49 4.4865108
243x50 7.463334109
253x51 5.781674247
263x53 3.960834107
273x55 4.530834247
28I2x51 5.31917425
294x50 5.69254179
304x64 3.84405
31E2.R195 3.91417411
32E2x50 4.73333619
33E2x51 3.25375814
34E2x52 4.0575416
355x36 3.55208814
365x37 2.87583404
375x39 4.0325415
385x47 9.17754188
395x51 4.094675186
405x58 5.232675239
415x60 4.17254244
425x65 3.493334118
436x31 3.489057116
446x41 3.45407
456x45 4.11167409
466x48 6.675834228
476x49 3.6385185
486x51 4.29067507
496x52 9.355408
506x55 4.45056616
516x58 10.0375414
526x62 6.14867515
537x26 2.52401
547x28 4.12083402
557x31 4.646514
567x34 8.49667514
577x35 5.46067515
587x38 5.14333415
597x45 5.639174229
607x53 4.870834109
617x54 4.224146
628x48 2.81083405
638x50 4.3465148
648x52 1.9475405
658x54 2.731674145
66G.HN.37 1.65083403
67G.S1.02 4.50917425
68G.S1.03 3.15083409
69G.S1.04 3.67417427
70G.S1.06 5.25428
71G.S1.07 5.00833459
72G.H1.04 5.70917427
73G.S2.04 5.31917426
74G.S2.06 4.978528
75G.S2.08 4.40467525
76G.s2s3.01 5.5425
77G.S3.03 4.49714727
78G.S3.04 7.8565197
79G.S3.05 3.7925427
80G.S3.07 4.79333429
81G.s3h2.03 4.22533549
82G.H2.05 6.20667447
83G.H2.06 3.94549
84G.H2.07 4.457671049
85G.h2s4.01 6.465449
86G.S4.03 4.37833428
87G.S4.04 5.606559
88G.s4h3.02 3.666674129
89G.s4h3.04 5.045566128
90G.s4h3.05 4.1265129
91G.H3.01 6.50917409
92G.H3.09 7.02167459
93G.H3.17 4.99238755
94G.H3.18 5.26533559
95G.S5.02 3.75833456
96G.S5.03 4.23333428
97G.S5.05 3.77167829
98G.hgh4.01 3.133334125
99G.hgh4.02 3.4625408
100G.hgh4.05 6.04667506
101G.H4.10 6.32583406
102G.H4.15 4.79667408
103G.S6.02 6.311116118
104G.S6.03 5.68833405
105G.S6.05 4.786675255
106G.s6h5.01 4.45583429
107G.s6h5.05 4.32417429
108G.H5.03 4.916528
109G.H5.08 5.13933528
110G.H5.13 4.600566118
111G.H5.20 4.10917408
112G.H5.23 4.121116104
113G.H5.26 3.21333609
114b.1x15 3.6825437
115b.1x19 4.90667436
116b.h2x1 3.45933505
117b.lhb1x3 3.4375402
118b.lhb1x6 3.01933583
119b.b1x4 5.219174157
120b.l1x3 8.442579
121b.l1x7 4.26867579
122b.b2x1 7.19733558
123b.b2x5 6.43667607
124b.b3x3 3.34598
125b.b3x4 4.67833479
126b.l3x2 6.27583409
127b.b4x2 5.04417408
128b.b4x3 3.22533597
129b.b4x5 4.31583497
130b.b4x6 7.85714779
131b.b5x2 4.81167407
132b.b5x3 6.21667779
133b.b5x5 4.50833495
134b.b5x7 4.48417407
135b.l5x1 3.46133598
136b.l5x5 5.38458849
137b.b6x1 2.8625409
138b.b6x5 3.908506
139b.l6x5 5.860834204
140b.b7x1 5.159335204
141b.l7x2 3.864549
142b.b8x4 5.00067596
143b.b9x3 4.17333406
144b.l9x3 7.22889649
145b.l9x6 4.92296948
146b.b10x5 4.98083409
147b.l10x1 4.11333403
148b.b11x1 4.95167405
149b.b11x4 5.36449
150b.l11x2 6.504549
151b.b12x6 7.91238748
152b.b13x7 7.28333567
153b.l13x3 7.0181769
154b.l13x7 4.18533569
155b.b14x1 3.8175448
156b.b15x1 6.41417469
157b.b15x2 6.8475436
158b.b15x3 3.65083469
159b.l15x1 4.2875447
160b.l15x2 6.0775469
161b.b16x2 3.82583465
162b.b16x4 9.04733566
163b.b16x5 4.48917435
164b.b16x6 7.57768
165b.b17x5 6.52867537
166b.b17x7 7.078538
167b.l17x3 8.84667639
168b.l17x6 5.28333649
169b.b18x3 4.11917438
170b.l18x1 5.44958886
171b.l18x2 6.02487
172b.b19x2 6.54778636
173b.b19x4 5.13067538
174b.l19x2 6.92667439
175b.b20x2 4.896536
176b.b20x4 9.80133538
177b.b20x6 7.05778636
178b.b21x1 8.58667437
179b.b21x2 3.66667506
180b.b21x5 3.3404
181b.b21x7 6.36611605
182b.b22x1 3.31083458
183b.b22x5 5.234587
184b.l22x5 6.13889689
185b.b23x6 6.585566217
186b.l23x1 7.9456
187b.b24x3 3.05333405
188b.b24x6 8.230834218
189b.l24x3 4.4825405
190b.l25x3 10.7965139
191b.l25x6 10.2317458
192b.l27x1 8.95714759
193b.l27x2 8.254139
194b.b28x3 4.65333477
195b.b28x4 8.097335136
196b.b28x6 8.730675139
197g.h1x8 3.24333407
198g.l1x4 5.38667438
199g.h2x11 8.38917486
200g.ctx3 5.92778609
201g.ctx6 3.32917406
202g.ctx14 5.205834159
203g.ctx15 6.315834159
204g.ctx16 4.875428158
205Lig 4.809052110
206E2.D174 2.2425400
207E2.P167 1.78333500
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x43 6x45 43.88993.24667YesYes089
25x51 6x45 42.17632.63YesYes069
35x47 5x51 41.12674.94667YesYes1886
45x47 6x52 40.414922.6233YesYes088
53x37 6x52 29.02483.26667YesYes078
63x37 Lig 24.06685.44333YesYes070
72x37 2x40 10.54883.96333NoYes077
82x37 G.H5.22 11.54533.71667NoNo074
9G.H5.22 G.H5.23 12.56254.03NoYes044
103x50 7x53 54.4596.86YesYes1099
113x43 7x53 51.74813.91YesYes089
122x42 4x42 15.59954.6YesNo078
132x42 3x49 19.69494.52YesYes078
143x49 G.H5.23 10.5224.23YesYes1084
153x50 G.H5.25 58.484614.5767YesNo098
16G.H5.20 G.H5.25 58.65545.99667YesNo088
17G.H5.19 G.H5.23 24.58873.49NoYes1084
18G.H5.15 G.H5.19 35.99013.30333NoNo088
19G.H5.15 I2x51 36.22513.93667NoYes085
20G.H5.08 I2x51 21.03345.14667YesYes285
21G.S3.01 I2x51 15.48368.17NoYes045
22G.S3.01 G.S3.03 15.59935.84667NoYes047
23G.H5.08 G.S3.03 15.91183.21333YesYes287
245x65 G.H5.20 29.18562.76667YesYes088
255x65 6x31 29.28644.85667YesYes1186
26G.H5.20 G.H5.26 29.41763.85667YesYes089
276x31 G.H5.13 30.44853.17667YesYes1168
28G.H5.17 G.H5.26 31.09592.95667NoYes059
29G.H5.13 G.H5.17 31.13923.56333YesNo1185
30G.H5.13 G.S6.02 61.878311.11YesYes1188
31G.H5.10 G.S6.02 62.217312.31NoYes078
32G.H5.10 G.S5.03 31.12935.97333NoYes078
33G.S5.03 G.S5.05 41.62912.93YesYes289
34G.S5.05 G.s6h5.01 99.50845.18667YesYes299
35G.S5.07 G.s6h5.01 1003.41333NoYes099
36G.S5.07 G.s5hg.01 99.68032.33NoNo099
37G.s4h3.02 G.s5hg.01 98.98573.06YesNo1299
38G.HG.07 G.s4h3.02 98.94394.08NoYes1299
39G.HG.07 G.s4h3.04 97.590810.8267NoYes1298
40G.HG.04 G.s4h3.04 93.9314.11NoYes088
41G.HG.04 G.s4h3.01 93.58216.57333NoNo087
42G.S5.06 G.s4h3.01 93.51267.49667NoNo097
43G.S5.06 G.S6.05 93.44374.87NoYes095
44G.H4.12 G.S6.05 94.0552.87NoYes055
45G.H4.12 G.S6.03 93.98412.3633NoYes055
46G.S5.04 G.S6.03 92.79236.79NoYes095
47G.H4.15 G.S5.04 92.72044.87333YesNo089
48G.H3.09 G.H4.15 91.63425YesYes098
49G.H3.09 G.S4.04 91.835311.43YesYes599
50G.S1.07 G.S4.04 55.78496.90333YesYes599
51G.S1.07 G.S4.02 51.87863.33YesNo598
52G.H3.18 G.S4.02 50.53539.21YesNo598
53G.H3.17 G.H3.18 52.2662.62333YesYes559
54G.H3.17 b.l27x1 36.23833.74667YesYes559
55b.b26x1 b.l27x1 43.85344.53NoYes099
56b.b26x1 b.b26x2 43.69583.44NoNo097
57b.b26x2 b.l1x7 32.08822.73NoYes079
58G.H5.10 G.S6.04 31.14472.94NoNo079
59G.S5.05 G.S6.04 31.0853.39333YesNo299
60b.b4x6 b.b5x3 11.451611.6YesYes799
61b.b3x6 b.l1x7 15.52952.58NoYes799
62b.b3x6 b.l3x2 15.38588.83NoYes099
63b.b4x2 b.l3x2 14.51316.91667YesYes089
64G.S1.04 G.S3.03 20.7532.86667YesYes277
65G.S1.04 G.S3.05 10.69434.24YesYes277
66G.S2.06 G.S3.03 11.1289.29YesYes287
67G.S2.06 G.S3.05 16.78983.31667YesYes287
68G.S1.04 G.S4.01 10.5074.59333YesNo078
69G.S3.05 G.S4.03 26.91992.9YesYes278
70G.H3.08 G.S4.04 35.88934.84NoYes089
71G.H2.04 G.H3.08 35.68113.64333NoNo098
72G.H2.04 G.H2.07 35.67533.33333NoYes099
73G.H2.07 b.l17x6 34.8932.60667YesYes499
74b.l17x5 b.l17x6 36.73663.43667NoYes069
75b.l17x5 b.l19x2 36.52943.92667NoYes069
76b.b20x2 b.l19x2 27.30498.19YesYes369
77b.b20x2 b.b20x4 18.30233.88YesYes368
78b.b20x4 b.b20x6 17.69684.63333YesYes386
79b.b17x7 b.b20x6 12.933113.2167YesYes386
80b.b17x7 b.b21x1 11.22683.18667YesYes387
81G.H3.17 b.l25x6 15.38533.66667YesYes558
82b.b26x2 b.b2x3 11.5135.4NoNo076
83b.b2x3 b.b2x5 11.34993.49333NoYes067
84b.b2x5 b.l4x1 10.05144.94333YesNo075
85b.b4x2 b.b5x8 13.0424.46YesNo085
86b.b5x7 b.b5x8 12.86812.82333YesNo075
87b.b2x4 b.b6x5 13.95133.99667NoYes066
88b.b10x4 b.b2x4 13.68029.78333NoNo066
89b.b19x4 b.l17x3 15.94127.75667YesYes389
90b.b16x5 b.l14x6 10.13024.15333YesNo353
91G.S4.03 G.S5.05 27.27244.12667YesYes289
92G.S4.01 G.S5.03 10.56433.66333NoYes088
933x49 3x53 10.43694.32667YesYes1087
943x53 G.H5.19 11.09233.73667YesNo1078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x322x644.686670YesYes3521
1x327x314.470YesYes3421
1x352x644.153331YesYes6521
1x357x357.221YesYes6522
2x602x645.566671YesYes7511
2x603x293.241YesYes7511
2x603x325.336671YesNo7712
2x632x646.606671YesYes5511
2x63E1x504.503331YesYes5812
2x63E2x503.583331YesYes5912
2x63Lig2.913331YesYes5010
2x64Lig4.473331YesYes5010
E1x50E2x508.706671YesYes8922
3x293x333.136671YesNo5511
3x29E2x503.251YesYes5912
3x29E2x524.366671YesYes5611
3x29Lig5.561YesYes5010
3x304x573.196670NoNo6712
3x304x6112.280NoNo6512
3x363x372.776670NoYes7721
3x376x523.266670YesYes7812
4x595x395.753330NoYes8521
4x605x394.211NoYes4511
4x635x362.980NoYes4421
E2.K196E2.R1955.776670NoYes0021
E2.R195E2.T2013.021YesNo0012
E2.R195E2x513.086671YesYes0411
E2.R195Lig3.773331YesYes0010
E2.T201E2x516.656671NoYes0421
E2x51Lig4.333331YesYes4010
E2.T205E2x523.373331NoYes0611
E2x52Lig5.181YesYes6010
5x36E2.T2053.746671YesNo4011
E2.T205Lig3.356671NoYes0010
5x36E2.T2063.746671YesNo4012
5x365x406.81YesNo4512
5x395x433.483331YesNo5512
5x406x556.143331NoYes5621
5x406x597.393331NoNo5422
5x446x525.90NoYes5822
5x446x553.946670NoYes5621
6x516x525.630YesYes7822
6x517x382.710YesYes7521
6x556x595.766671YesNo6412
6x557x343.613331YesYes6411
6x586x6210.531YesYes4511
6x587x3422.431YesYes4411
6x62E3.Q2913.503331YesNo5012
6x62Lig8.481YesYes5010
7x317x356.776671YesYes4512
7x31Lig3.641YesYes4010
7x347x353.346671YesYes4512
7x347x387.841YesYes4511
7x34Lig5.253331YesYes4010
7x357x385.821YesYes5521
7x38Lig4.203331YesYes5010
2x60E2x513.921YesYes7411
2x60Lig4.986671YesYes7010
3x33Lig13.191NoYes5010
3x37Lig5.443330YesYes7010
4x60Lig8.096671NoYes4010
E2x50E2x512.793331YesYes9421
6x62E2.Y1874.381YesNo5012
6x63E2.Y1873.740NoNo3022
5x366x632.681YesNo4312
5x39Lig2.683331YesYes5010
6x516x553.843330YesYes7621
6x55Lig3.391YesYes6010
6x587x312.843331YesYes4411
6x58Lig4.346671YesYes4010
1x287x315.50NoYes0421
2x633x212.636671YesNo5612
2x633x243.233331YesNo5512
3x21E2x502.786671NoYes6922
3x30Lig2.776670NoYes6010
3x375x433.583330YesNo7512
E2.K174E2x523.310NoYes0621
6x62E2x513.851YesYes5411
5x36E2.K1793.056671YesNo4012
5x36Lig3.993331YesYes4010
2x63E1.L872.503331YesNo5012
3x375x4612.393330YesNo7512
2x63E1.T1151.663331YesNo5012
5x366x601.413331YesNo4412
E2.G193E2x510.9666670NoYes0421
LigNT.T450.9166671YesNo0001
E2.S207E2x510.4233330NoYes0421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
57.69Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
57.14Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
55.56Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
54.55Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
54.55Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
54.17Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
52.00Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
51.85Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
51.85Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
50.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
50.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
50.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
50.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
48.28Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.28Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
48.28Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.28Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.28Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
48.28Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
48.15Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
48.15Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
48.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
48.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
47.83Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
47.83Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
47.83Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
47.83Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
47.83Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
47.62Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
47.62Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
47.62Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
46.43Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
46.15Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
46.15Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
46.15Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
46.15Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
46.15Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
45.83Single8ZPLHF511168ZPL-CXCR4-HF51116
45.83Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
45.83Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
45.16Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
45.16Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
45.16Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
45.16Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
45.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
44.83Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
44.83Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
44.83Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
44.44Single3OE0CVX153OE0-CXCR4-CVX15
44.44Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
44.44Consensusangiotensin_onOrthosteric Ligandat1_on
44.44Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
44.44Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
44.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
44.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
44.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
43.48Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.48Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
43.48Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
43.48Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
43.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
43.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
42.86Single6JODAngiotensin II6JOD-AT2-Angiotensin II
42.86Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
42.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
42.86Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
42.86Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
42.86Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
42.86Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.86Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
42.86Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
42.86Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.31Single4XT1Fractalkine4XT1-US28-Fractalkine
42.31Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
42.31Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
42.31Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
41.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
41.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
41.67Single6OS2TRV0266OS2-AT1-TRV026
41.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
41.67Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
41.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
41.38Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
41.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
41.38Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
41.38Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
41.38Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
41.38Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
41.38Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
41.38Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
40.91Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
40.91Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.91Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.91Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.91Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.91Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
40.74Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
40.74Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.74Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
40.74Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
40.74Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.74Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
40.74Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.74Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
40.62Single5GLHEndothelin-15GLH-ETB-Endothelin-1
40.62Single6IGKEndothelin-36IGK-ETB-Endothelin-3
40.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
40.00Single4XT3Fractalkine4XT3-US28-Fractalkine
40.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
40.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
40.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
40.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
40.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
39.39Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
39.29Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
39.29Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
39.29Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
39.29Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
39.29Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.29Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
39.29Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.29Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
39.29Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
39.29Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
39.13Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
38.71Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
38.71Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
38.46Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
38.46Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
38.46Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
38.46Single8QJ2pN1628QJ2-MC4-pN162-Gs
38.46Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
38.46Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
38.46Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.46Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
38.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
38.10Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
38.10Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
37.93Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.93Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
37.93Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
37.93Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
37.93Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
37.50Single6IGLIRL16206IGL-ETB-IRL1620
37.50Single6OS1TRV0266OS1-AT1-TRV026
37.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
37.50Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
37.50Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
37.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
37.50Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
37.50Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
37.50Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
37.50Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.50Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.50Consensusbradykinin_onOrthosteric Ligandbk2_on
37.50Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
37.50Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
37.50Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
37.50Consensusendothelin_onOrthosteric Ligandetb_on eta_on
37.50Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.04Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
37.04Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
37.04Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
37.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
37.04Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
37.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
37.04Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
37.04Single8XWNCXCL88XWN-CXCR2-CXCL8
37.04Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
37.04Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
37.04Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
37.04Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
37.04Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.04Consensuslpl_onOrthosteric Ligands1p_on lpa_on
37.04Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
36.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
36.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
36.67Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
36.67Single8ZRTET-18ZRT-ETB-ET-1
36.67Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
36.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
36.67Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
36.36Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
36.36Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
36.36Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
36.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
36.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
36.00Single4XESNeurotensin4XES-NTS1-Neurotensin
36.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
36.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
36.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
36.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
36.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
36.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
36.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
36.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
36.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
36.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
36.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
36.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
36.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
36.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
35.71Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
35.71Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
35.71Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
35.71Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
35.71Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
35.71Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
35.71Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
35.71Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
35.71Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
35.71Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
35.48Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
35.48Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
35.48Single7SK3CXCL127SK3-ACKR3-CXCL12
35.48Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
35.48Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
35.48Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.48Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
35.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
34.78Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
34.78Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
34.62Single4BUONeurotensin4BUO-NTS1-Neurotensin
34.62Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
34.62Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
34.62Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
34.62Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
34.62Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
34.62Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
34.62Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
34.62Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
34.62Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Single8XVUCXCL28XVU-CXCR2-CXCL2
34.62Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
34.62Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
34.62Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
34.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.62Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
34.62Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.62Consensusprostanoid_offOrthosteric Ligandep_off dp_off
34.48Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
34.48Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.48Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
34.48Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
34.48Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.48Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
34.48Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
34.48Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
34.48Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.48Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.48Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single9KDFRES-701-39KDF-ETB-RES-701-3
34.38Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
34.29Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Single3OE9IT1t3OE9-CXCR4-IT1t
33.33Single4NTJAZD12834NTJ-P2Y12-AZD1283
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
33.33Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
33.33Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
33.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
33.33Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
33.33Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
33.33Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
33.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
33.33Single7XN9L-054,5227XN9-SST2-L-054,522
33.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
33.33Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
33.33Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
33.33Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
33.33Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9EHSLUF76029EHS-A3A-LUF7602
33.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
33.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
33.33Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
33.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
33.33Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
33.33Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
33.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
33.33Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.35Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
32.35Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.26Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
32.26Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.26Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
32.26Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
32.26Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
32.26Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
32.14Single4IARErgotamine4IAR-5-HT1B-Ergotamine
32.14Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
32.14Single7F8XNN90567F8X-CCKA-NN9056
32.14Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
32.14Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
32.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
32.14Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
32.14Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
32.14Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
32.14Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
32.14Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
32.14Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
32.14Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
32.14Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
32.14Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.14Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.14Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
32.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
32.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
32.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
32.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
32.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
32.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
32.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
32.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
32.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
32.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
32.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
32.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
32.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
32.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
32.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
32.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
32.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
32.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
32.00Consensusneurotensin_onOrthosteric Ligandnts1_on
32.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
32.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
32.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
31.82Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
31.82Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
31.82Single8GNGIstradefylline8GNG-A2A-Istradefylline
31.82Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
31.82Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
31.82Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
31.82Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
31.82Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
31.82Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
31.82Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
31.82Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.58Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.58Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
31.43Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
31.43Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.43Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
31.43Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
31.25Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
31.25Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.25Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
31.03Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
31.03Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
31.03Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.03Single7SK5CXCL127SK5-ACKR3-CXCL12
31.03Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.03Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
31.03Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
31.03Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
31.03Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.03Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.03Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.03Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.03Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
30.77Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
30.77Single6KQICP559406KQI-CB1-CP55940-Org27569
30.77Single6YVRNTS8-136YVR-NTS1-NTS8-13
30.77Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.77Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.77Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.77Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.77Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.77Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
30.77Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.77Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
30.77Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
30.77Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
30.77Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
30.77Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Single8XQJJN2418XQJ-Apelin-JN241
30.77Single8XWACXCL18XWA-CXCR2-CXCL1
30.77Single8XWMCXCL68XWM-CXCR2-CXCL6
30.77Single8XWSCXCL58XWS-CXCR2-CXCL5
30.77Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
30.77Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
30.77Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.77Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.77Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.77Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.77Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.77Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
30.77Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.77Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.77Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.43Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.43Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
30.43Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.43Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
30.43Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
30.43Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
30.43Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
30.43Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
30.43Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
30.43Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
30.43Consensushca_onOrthosteric Ligandhca2_on
30.30Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
30.30Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
30.30Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
30.00Single5WF5UK-4320975WF5-A2A-UK-432097
30.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
30.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
30.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
30.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
30.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
30.00Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
30.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.00Consensusp2y_offOrthosteric Ligandp2y1_off
29.63Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
29.63Single7EZCUKA7EZC-A2A-UKA
29.63Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.63Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
29.63Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
29.63Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
29.63Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
29.63Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
29.63Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
29.63Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
29.63Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
29.63Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
29.63Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
29.63Single8XWFCXCL38XWF-CXCR2-CXCL3
29.63Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
29.63Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
29.63Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
29.63Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.63Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.63Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.41Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
29.17Single4QIMANTA XV4QIM-SMO-ANTA XV
29.17Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
29.17Single5UIGCmpd-15UIG-A2A-Cmpd-1
29.17Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.17Single6D27CAY104716D27-DP2-CAY10471
29.17Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
29.17Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
29.17Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.17Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
29.17Single7V3ZCP559407V3Z-CB1-CP55940
29.17Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
29.17Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
29.17Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
29.17Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.17Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.17Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.17Single8K5DGSK2560738K5D-HCA2-GSK256073
29.17Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.17Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
29.17Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
29.17Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
29.17Single9H37A1IR09H37-A2A-A1IR0-Na
29.17Single9IYAONO-97105319IYA-GPR55-ONO-9710531
29.17Consensusa3_onOrthosteric Liganda3a_on
29.17Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
29.17Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
29.17Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.17Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
29.17Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.17Consensushca_on_gpOrthosteric Ligandhca2_on_gp
29.03Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.03Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
29.03Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
29.03Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
29.03Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.03Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.03Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
29.03Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
28.57Single3OE6IT1t3OE6-CXCR4-IT1t
28.57Single4XNWMRS25004XNW-P2Y1-MRS2500
28.57Single5ZTYAM102575ZTY-CB2-AM10257
28.57Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
28.57Single6KNMJN241-96KNM-Apelin-JN241-9
28.57Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
28.57Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
28.57Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
28.57Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
28.57Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
28.57Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.57Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
28.57Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
28.57Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
28.57Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
28.57Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
28.57Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
28.57Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Consensusbombesin_onOrthosteric Ligandbb2_on
28.57Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
28.57Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.57Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
28.12Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.12Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.12Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
28.12Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
28.12Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.12Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.12Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.12Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
28.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
28.00Single5N2SPSB365N2S-A1-PSB36
28.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
28.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
28.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
28.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
28.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
28.00Single7W41PD1762527W41-BB2-PD176252
28.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
28.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
28.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
28.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
28.00Single8S4DCMF-0198S4D-Apelin-CMF-019
28.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
28.00Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
28.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
28.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
28.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
28.00Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
28.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
28.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.00Consensusbombesin_offOrthosteric Ligandbb2_off
28.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
28.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
28.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
27.59Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
27.59Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
27.59Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.59Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.59Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
27.59Single8WDTphotoNECA8WDT-A2A-photoNECA
27.59Single8WKYPG-9348WKY-MC4-PG-934
27.59Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
27.59Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
27.59Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.59Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.59Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.59Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
27.50Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
27.27Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
27.27Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.27Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
27.27Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
27.27Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
27.27Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
27.27Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
27.27Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
26.92Single4BV0Neurotensin4BV0-NTS1-Neurotensin
26.92Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.92Single5TZRMK86665TZR-FFA1-MK8666
26.92Single5XR8AM8415XR8-CB1-AM841
26.92Single5XRAAM115425XRA-CB1-AM11542
26.92Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
26.92Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.92Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
26.92Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
26.92Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
26.92Single7B6WCyclazosin7B6W-α1b-Cyclazosin
26.92Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.92Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
26.92Single7F1TMIP-1a7F1T-CCR5-MIP-1a
26.92Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
26.92Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
26.92Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.92Single7R0CAVP7R0C-V2-AVP-Arrestin2
26.92Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
26.92Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.92Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.92Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
26.92Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.92Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.92Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8E0GBU728E0G-μ-BU72
26.92Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
26.92Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.92Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
26.92Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.92Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
26.92Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.92Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
26.92Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
26.92Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
26.92Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.92Single8ZWFJR14a8ZWF-C3aB-JR14a
26.92Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.92Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
26.92Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
26.92Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
26.92Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.92Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Consensuslpa_onOrthosteric Ligandlpa1_on
26.92Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
26.92Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.92Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.67Single3QAKUK-4320973QAK-A2A-UK-432097
26.67Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.67Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.67Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
26.67Single7XNACYN1548067XNA-SST2-CYN154806
26.67Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.67Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
26.67Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
26.67Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.67Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.67Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.67Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
26.47Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.47Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
26.47Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
26.09Single3ODUIT1t3ODU-CXCR4-IT1t
26.09Single3PWHZM-2413853PWH-A2A-ZM-241385
26.09Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
26.09Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
26.09Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.09Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.09Single6ME9Ramelteon6ME9-MT2-Ramelteon
26.09Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
26.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
26.09Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
26.09Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
26.09Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
26.09Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.09Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
26.09Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
26.09Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.09Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
26.09Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
26.09Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.09Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.93Single4RWADIPP-NH24RWA-δ-DIPP-NH2
25.93Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
25.93Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.93Single6MXTSalmeterol6MXT-β2-Salmeterol
25.93Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
25.93Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.93Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.93Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
25.93Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
25.93Single8JJLOlodaterol8JJL-β2-Olodaterol
25.93Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
25.93Single8JWY2-1188JWY-A2A-2-118
25.93Single8JWZAB9288JWZ-A2A-AB928-Na
25.93Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
25.93Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
25.93Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
25.93Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.93Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.93Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
25.93Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.93Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.93Consensuslpa_offOrthosteric Ligandlpa1_off
25.93Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.93Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.93Consensusorexin_onOrthosteric Ligandox2_on
25.93Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.81Single6W25SHU91196W25-MC4-SHU9119-Ca
25.81Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.81Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.81Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.00Single3REYXAC3REY-A2A-XAC
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
25.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
25.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7F61PF-036547467F61-H3-PF-03654746
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
25.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IHKAcifran8IHK-HCA3-Acifran
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
25.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
25.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.00Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.00Single8ZPMAMD0708ZPM-CXCR4-AMD070
25.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
25.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.00Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
25.00Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
25.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
25.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.39Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
24.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
24.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
24.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
24.24Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.14Single4UG2CGS216804UG2-A2A-CGS21680
24.14Single5WF6UK-4320975WF6-A2A-UK-432097
24.14Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
24.14Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
24.14Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
24.14Single9IPYJR14a9IPY-C3aB-JR14a
24.14Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
24.14Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Single3EMLZM-2413853EML-A2A-ZM-241385
24.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.00Single4YAYZD-71554YAY-AT1-ZD-7155
24.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
24.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
24.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
24.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
24.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
24.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
24.00Single6S0LZM-2413856S0L-A2A-ZM-241385
24.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
24.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
24.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
24.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
24.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
24.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
24.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.00Single8CU6LJ-45178CU6-A2A-LJ-4517
24.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
24.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
24.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
24.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
24.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
24.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
24.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
24.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
24.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
24.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
24.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
24.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
24.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
24.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
24.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
23.81Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.53Single6FJ3PTH6FJ3-PTH1-PTH
23.53Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.53Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
23.53Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
23.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
23.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
23.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
23.33Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
23.33Single8IEBA1LYA8IEB-GPR156-A1LYA
23.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Single9M4TSilodosin9M4T-Alpha1A-Silodosin
23.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
23.33Consensussomatostatin_offOrthosteric Ligandsst2_off
23.08Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
23.08Single5C1MBU725C1M-μ-BU72
23.08Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.08Single5N2RPSB-365N2R-A2A-PSB-36-Na
23.08Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
23.08Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.08Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
23.08Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
23.08Single6S0QZM-2413856S0Q-A2A-ZM-241385
23.08Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
23.08Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.08Single7C4SS1P7C4S-S1P3-S1P
23.08Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.08Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
23.08Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
23.08Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
23.08Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
23.08Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
23.08Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.08Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
23.08Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
23.08Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.08Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
23.08Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
23.08Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
23.08Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
23.08Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.08Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
23.08Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
23.08Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.86Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
22.86Consensusglp_onOrthosteric Ligandglp1_on glp2_on
22.86Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
22.73Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
22.73Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
22.58Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
22.58Single8IEBA1LYA8IEB-GPR156-A1LYA
22.50Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.22Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
22.22Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
22.22Single5V56TC1145V56-SMO-TC114
22.22Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
22.22Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
22.22Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
22.22Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
22.22Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
22.22Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
22.22Single7PX4PSB-21137PX4-A2A-PSB-2113
22.22Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
22.22Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.22Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
22.22Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.22Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.22Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
22.22Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
22.22Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.22Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
22.22Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
22.22Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
22.22Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
22.22Consensusa2_onOrthosteric Liganda2b_on
22.22Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.22Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.22Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
22.22Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
21.88Single6PT2KGCHM076PT2-δ-KGCHM07
21.88Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
21.88Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
21.74Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.74Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.74Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.74Single8K5BNiacin8K5B-HCA2-Niacin
21.74Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
21.74Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
21.74Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
21.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.62Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
21.62Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
21.62Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
21.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.43Single3D4STimolol3D4S-β2-Timolol
21.43Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.43Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.43Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
21.43Single6ZG4HTL00099366ZG4-M1-HTL0009936
21.43Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
21.43Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.43Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
21.43Single7K15MKD0467K15-BLT1-MKD046-Na
21.43Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
21.43Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
21.43Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
21.43Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.43Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
21.43Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.43Single7YITNalfurafine7YIT-κ-Nalfurafine
21.43Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.43Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.43Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
21.43Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.43Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single9DGIZ85267113509DGI-CB1-Z8526711350
21.43Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
21.43Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
21.43Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
21.43Consensusalpha1_offOrthosteric Ligandalpha1a_off
21.43Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
21.43Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.43Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.43Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.43Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.43Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.21Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
21.21Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.21Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.21Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
21.05Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.05Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.05Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.83Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
20.83Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.83Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.83Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.83Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.83Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.83Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.83Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.83Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.83Single7F8YDevazepide7F8Y-CCKA-Devazepide
20.83Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.83Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
20.83Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.83Single7XRRLemborexant7XRR-OX2-Lemborexant
20.83Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.83Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.83Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.83Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.83Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.83Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
20.83Single9H2XA1IR19H2X-A2A-A1IR1-Na
20.83Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
20.83Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.83Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.69Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.69Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.69Single6IBLArformoterol6IBL-β1-Arformoterol
20.69Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.69Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
20.69Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
20.69Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.69Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
20.69Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
20.69Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
20.69Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
20.69Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.69Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
20.69Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
20.69Consensuschemerin_onOrthosteric Ligandcml1_on
20.69Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.69Consensusendothelin_offOrthosteric Ligandetb_off
20.69Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
20.59Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.59Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.59Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
20.59Consensuspac_onOrthosteric Ligandpac1_on
20.59Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
20.59Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
20.51Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
20.51Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
20.51Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
20.45Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
20.00Single3NY9ICI118-5513NY9-β2-ICI118-551
20.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM-2413855JTB-A2A-ZM-241385
20.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
20.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6AQFZM-2413856AQF-A2A-ZM-241385
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZINSR486926ZIN-NTS1-SR48692
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7UL3Famotidine7UL3-H2-Famotidine
20.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
20.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8RLNLUF58348RLN-A2A-LUF5834
20.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
20.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
20.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.00Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.00Single9JF4PD1683689JF4-BB1-PD168368
20.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
20.00Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
20.00Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
20.00Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
20.00Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
20.00Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
20.00Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
19.51Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
19.44Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
19.44Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
19.44Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
19.44Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
19.44Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
19.44Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
19.44Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
19.44Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
19.44Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
19.35Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
19.35Single8IEIA1LYA8IEI-GPR156-A1LYA
19.35Single8IEIA1LYA8IEI-GPR156-A1LYA
19.35Single8IEPA1LYA8IEP-GPR156-A1LYA
19.35Single8IEPA1LYA8IEP-GPR156-A1LYA
19.35Single8KIGSHU91198KIG-MC3-SHU9119-Ca
19.35Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
19.35Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
19.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.23Single2Y02Carmoterol2Y02-β1-Carmoterol
19.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.23Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
19.23Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
19.23Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
19.23Single5DHGC-355DHG-NOP-C-35
19.23Single5DHHSB-6121115DHH-NOP-SB-612111
19.23Single5IU8Q274563475IU8-A2A-Q27456347-Na
19.23Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
19.23Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.23Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.23Single5T04Neurotensin5T04-NTS1-Neurotensin
19.23Single5UENDU1725UEN-A1-DU172
19.23Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.23Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
19.23Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
19.23Single6PS1Timolol6PS1-β2-Timolol
19.23Single6TOTLemborexant6TOT-OX1-Lemborexant
19.23Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.23Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
19.23Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
19.23Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
19.23Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.23Single7PYRPSB-21157PYR-A2A-PSB-2115
19.23Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
19.23Single7UL4Alvimopan7UL4-μ-Alvimopan
19.23Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.23Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.23Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.23Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.23Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
19.23Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
19.23Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.23Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
19.23Single9CHXS-Carazolol9CHX-β2-S-Carazolol
19.23Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
19.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
19.23Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.23Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusblt_onOrthosteric Ligandblt1_on
19.23Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
19.23Consensuscck_offOrthosteric Ligandccka_off
19.23Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.23Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.23Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
19.23Consensusleukotriene_onOrthosteric Ligandblt_on
19.23Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.05Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
19.05Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
19.05Single8PWNTheophylline8PWN-A2A-Theophylline
18.92Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
18.92Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
18.92Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.92Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.92Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
18.92Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
18.75Single6HLOAprepitant6HLO-NK1-Aprepitant
18.75Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.75Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.75Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single2YCWS-Carazolol2YCW-β1-S-Carazolol
18.52Single4JKVTaladegib4JKV-SMO-Taladegib
18.52Single5D6LS-Carazolol5D6L-β2-S-Carazolol
18.52Single5TVNLSD5TVN-5-HT2B-LSD
18.52Single5XPRBosentan5XPR-ETB-Bosentan
18.52Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.52Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.52Single6PS6Timolol6PS6-β2-Timolol
18.52Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
18.52Single6Z4SSR486926Z4S-NTS1-SR48692
18.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.52Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.52Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.52Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.52Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.52Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.52Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.52Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8JXSPF-61428JXS-D1-PF-6142
18.52Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
18.52Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.52Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.52Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
18.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.52Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
18.52Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
18.52Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
18.52Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
18.52Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
18.52Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
18.52Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.52Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.52Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.52Consensusblt_offOrthosteric Ligandblt1_off
18.52Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.52Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
18.52Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.42Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.18Single3OE8IT1t3OE8-CXCR4-IT1t
18.18Single3RFMCaffeine3RFM-A2A-Caffeine
18.18Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
18.18Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.18Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.18Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.18Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.95Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
17.95Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single2YDVNECA2YDV-A2A-NECA
17.86Single3P0GBI1671073P0G-β2-BI167107
17.86Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.86Single4DJHJDTic4DJH-κ-JDTic
17.86Single4UHRCGS216804UHR-A2A-CGS21680
17.86Single5D5AS-Carazolol5D5A-β2-S-Carazolol
17.86Single5D5BS-Carazolol5D5B-β2-S-Carazolol
17.86Single5G53NECA5G53-A2A-NECA-Gs
17.86Single5V57TC1145V57-SMO-TC114
17.86Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.86Single6J20Aprepitant6J20-NK1-Aprepitant
17.86Single6J21Aprepitant6J21-NK1-Aprepitant
17.86Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.86Single6TQ7SB-3348676TQ7-OX1-SB-334867
17.86Single6WGTLSD6WGT-5-HT2A-LSD
17.86Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
17.86Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
17.86Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.86Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
17.86Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
17.86Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
17.86Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
17.86Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
17.86Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
17.86Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.86Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.86Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.86Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
17.86Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
17.86Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
17.86Single8XVLZibotentan8XVL-ETA-Zibotentan
17.86Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
17.86Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
17.86Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
17.86Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.86Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.86Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.86Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.86Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.65Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
17.65Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.65Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
17.65Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.50Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.50Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.50Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.39Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.39Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.39Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.39Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
17.39Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.39Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
17.39Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.39Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.39Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.39Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.39Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.24Single4AMIBucindolol4AMI-β1-Bucindolol
17.24Single4LDEBI1671074LDE-β2-BI167107
17.24Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.24Single6A93Risperidone6A93-5-HT2A-Risperidone
17.24Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.24Single7DFPSpiperone7DFP-D2-Spiperone
17.24Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
17.24Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
17.24Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.24Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.24Single8JJ8Formoterol8JJ8-β2-Formoterol
17.24Single8XYIVUF106618XYI-CXCR3-VUF10661
17.24Single9BJKNAM9BJK-μ-Naloxone-NAM
17.24Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.24Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.24Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.24Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
17.24Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
17.07Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single5X93K-87945X93-ETB-K-8794
16.67Single6H7LDobutamine6H7L-β1-Dobutamine
16.67Single6K1QIRL25006K1Q-ETB-IRL2500
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
16.67Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
16.67Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
16.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
16.67Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
16.67Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
16.67Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
16.67Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
16.67Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
16.28Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
16.22Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.22Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.22Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
16.22Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.22Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
16.22Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
16.13Single6PT3DPI-2876PT3-δ-DPI-287
16.13Single7SK9CCX6627SK9-ACKR3-CCX662
16.13Single8X5YAstemizole8X5Y-H1-Astemizole
16.13Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
16.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
16.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
16.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
16.00Single4QINSAG1.54QIN-SMO-SAG1.5
16.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
16.00Single5WS3EMPA5WS3-OX2-EMPA
16.00Single6AKXA4R6AKX-CCR5-A4R
16.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.00Single6B73MP11046B73-κ-MP1104
16.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
16.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
16.00Single7F8ULintitript7F8U-CCKA-Lintitript
16.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
16.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
16.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
16.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
16.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
16.00Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
16.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
16.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.00Consensusangiotensin_offOrthosteric Ligandat1_off
16.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
16.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.91Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
15.79Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.79Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.79Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.79Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.62Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.62Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
15.62Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
15.38Single2YDOAdenosine2YDO-A2A-Adenosine
15.38Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.38Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
15.38Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.38Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.38Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.38Single6KUXRS-799486KUX-α2a-RS-79948
15.38Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.38Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.38Single6PS0S-Carazolol6PS0-β2-S-Carazolol
15.38Single6PS4ICI118-5516PS4-β2-ICI118-551
15.38Single6PS5S-Propranolol6PS5-β2-S-Propranolol
15.38Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
15.38Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.38Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.38Single6TPGEMPA6TPG-OX2-EMPA
15.38Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.38Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.38Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
15.38Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
15.38Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.38Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.38Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
15.38Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
15.38Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
15.38Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
15.38Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
15.38Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
15.38Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
15.38Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.38Single8IYXYL-3658IYX-GPR34-YL-365
15.38Single8K2WAMG4878K2W-CXCR3-AMG487
15.38Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.38Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
15.38Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.38Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9AS5Mescaline9AS5-5-HT2A-Mescaline
15.38Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.38Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
15.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.15Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.15Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.15Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Single2Y04Salbutamol2Y04-β1-Salbutamol
14.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.81Single3NY8ICI118-5513NY8-β2-ICI118-551
14.81Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
14.81Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
14.81Single4EJ4Naltrindole4EJ4-δ-Naltrindole
14.81Single4GBRS-Carazolol4GBR-β2-S-Carazolol
14.81Single4QKX35V4QKX-β2-35V
14.81Single5TGZAM65385TGZ-CB1-AM6538
14.81Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.81Single6GPSMK08126GPS-CCR2-MK0812
14.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
14.81Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
14.81Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
14.81Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
14.81Single7BU7BI1671077BU7-β1-BI167107
14.81Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
14.81Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
14.81Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
14.81Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
14.81Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
14.81Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
14.81Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
14.81Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.81Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.81Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.81Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
14.81Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
14.81Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
14.81Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
14.81Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
14.81Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
14.81Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
14.81Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
14.81Single8JJOAlprenolol8JJO-β2-Alprenolol
14.81Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
14.81Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.81Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.81Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
14.81Single9AS1DMT9AS1-5-HT2A-DMT
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
14.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
14.81Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
14.81Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
14.81Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
14.81Consensusalpha2_onOrthosteric Ligandalpha2b_on
14.81Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
14.81Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
14.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.81Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
14.81Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
14.81Consensusdopamine_offOrthosteric Ligandd2_off d3_off
14.81Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
14.81Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
14.81Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.71Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
14.71Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
14.71Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
14.58Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
14.29Single2RH1S-Carazolol2RH1-β2-S-Carazolol
14.29Single2Y00Dobutamine2Y00-β1-Dobutamine
14.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.29Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5WIUNemonapride5WIU-D4-Nemonapride
14.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.29Single5WQCEMPA5WQC-OX2-EMPA
14.29Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6E67BI1671076E67-β2-BI167107-Gs(CT)
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
14.29Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
14.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
14.29Single6TP6Filorexant6TP6-OX1-Filorexant
14.29Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
14.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.29Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
14.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
14.29Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
14.29Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
14.29Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
14.29Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.29Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
14.29Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9HAPTolvaptan9HAP-V2-Tolvaptan
14.29Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.29Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.29Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.29Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
14.29Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
14.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
14.29Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.29Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.29Consensusamine_offonOrthosteric Ligandamine_off amine_on
14.29Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
14.29Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.29Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
14.29Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.29Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensustrace-amine_onOrthosteric Ligandta1_on
13.95Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.89Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.79Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.79Single6E59L-7607356E59-NK1-L-760735
13.79Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
13.79Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
13.79Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.79Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
13.79Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.79Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.79Single9BJKNaloxone9BJK-μ-Naloxone-NAM
13.79Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.79Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
13.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.79Consensustachykinin_offOrthosteric Ligandnk1_off
13.64Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.64Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
13.64Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.64Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
13.51Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.51Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.51Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
13.51Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.51Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
13.33Single4N4WSANT-14N4W-SMO-SANT-1
13.33Single5X33BIIL2605X33-BLT1-BIIL260
13.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.33Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.33Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.16Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.16Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.16Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.04Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.04Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.04Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
13.04Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.04Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
12.90Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.90Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.90Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.90Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.90Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
12.90Single8XVJMacitentan8XVJ-ETA-Macitentan
12.90Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
12.90Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.82Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.82Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single3UZAGTPL92363UZA-A2A-GTPL9236
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.50Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.50Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
12.50Single8JPSCCL78JPS-ACKR1-CCL7
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.20Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.20Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.20Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.12Single7QA8Peptide7QA8-STE2-Peptide
12.12Single7QA8Peptide7QA8-STE2-Peptide
12.12Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.12Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.00Single3PBLEticlopride3PBL-D3-Eticlopride
12.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.00Single6HLLCP999946HLL-NK1-CP99994
12.00Single6LI0C176LI0-GPR52-C17
12.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
12.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
12.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
12.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
12.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
12.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
12.00Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.00Single9B9Y7DY9B9Y-CB1-7DY
12.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
12.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
12.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
12.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.63Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.54Single5U09Taranabant5U09-CB1-Taranabant
11.54Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
11.54Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.54Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.54Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
11.54Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Single6TODEMPA6TOD-OX1-EMPA-Na
11.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.54Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
11.54Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.54Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.54Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.54Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.54Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.54Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
11.54Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
11.54Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
11.54Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
11.54Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
11.54Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
11.54Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
11.54Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.54Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
11.54Single8IWESpermidine8IWE-TA9-Spermidine
11.54Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.54Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.54Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.54Single8Y0HVUF114188Y0H-CXCR3-VUF11418
11.54Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
11.54Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
11.54Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.54Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.54Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.54Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
11.54Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.54Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
11.54Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.54Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.54Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
11.54Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
11.11Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.11Single3RZECidoxepin3RZE-H1-Cidoxepin
11.11Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
11.11Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.11Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.11Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.11Single6TPNHTL66416TPN-OX2-HTL6641
11.11Single6VI4JDTic6VI4-κ-JDTic
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
11.11Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.11Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
11.11Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.11Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
11.11Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
11.11Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
11.11Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
11.11Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
11.11Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.11Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.11Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
11.11Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
11.11Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
11.11Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
11.11Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
11.11Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
11.11Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
11.11Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
11.11Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
11.11Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
11.11Single9AS3LSD9AS3-5-HT2A-LSD
11.11Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
11.11Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
11.11Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
11.11Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.11Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
11.11Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
11.11Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.11Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
11.11Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.11Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.11Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
11.11Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.11Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.11Consensusopsins_offOrthosteric Ligandrhodopsin_off
11.11Consensussensory_offOrthosteric Ligandopsins_off
10.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.81Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.81Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.81Consensuscalcitonin_onOrthosteric Ligandctlike_on
10.71Single2Y01Dobutamine2Y01-β1-Dobutamine
10.71Single4MQSIperoxo4MQS-M2-Iperoxo
10.71Single4U14Tiotropium4U14-M3-Tiotropium
10.71Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.71Single6H7MSalbutamol6H7M-β1-Salbutamol
10.71Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.71Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.71Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.71Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.71Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.71Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
10.71Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.71Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.71Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.71Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
10.71Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.71Single8JXRLSD8JXR-D1-LSD
10.71Single8T1WCVN4248T1W-GPR6-CVN424
10.71Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
10.71Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
10.71Single8X63Mepyramine8X63-H1-Mepyramine
10.71Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
10.71Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
10.71Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.71Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
10.71Single9JEAAtropine9JEA-M1-Atropine
10.71Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
10.71Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
10.71Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
10.71Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.71Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.71Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.71Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.71Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.71Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
10.71Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.71Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.71Consensushistamine_offOrthosteric Ligandh1_off
10.71Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.71Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.64Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.53Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.53Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
10.53Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
10.53Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.42Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.34Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
10.34Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.34Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
10.34Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.34Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.34Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.34Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
10.34Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.34Single7WC6LSD7WC6-5-HT2A-LSD
10.34Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
10.34Single9B9ZA1AKO9B9Z-CB1-A1AKO
10.34Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
10.34Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
10.34Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
10.34Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.34Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
10.34Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.34Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.26Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
10.00Single4U15Tiotropium4U15-M3-Tiotropium
10.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.00Single6OL9Tiotropium6OL9-M5-Tiotropium
10.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
10.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
10.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.00Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.00Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
10.00Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
10.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.68Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.68Single5CXVTiotropium5CXV-M1-Tiotropium
9.68Single6CM4Risperidone6CM4-D2-Risperidone
9.68Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
9.68Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
9.68Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.68Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
9.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.38Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
9.38Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
9.09Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.70Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
8.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
8.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
8.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
8.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
8.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
8.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
8.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
8.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
8.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
8.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
8.00Single9LRCHistamine9LRC-H4-Histamine
8.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
8.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
8.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
8.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
7.69Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
7.69Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
7.69Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
7.69Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
7.69Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.69Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
7.69Single6TP4ACT-4622066TP4-OX1-ACT-462206
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Single7UL2SR486927UL2-NTS1-SR48692-Na
7.69Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
7.69Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
7.69Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
7.69Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
7.69Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.69Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.69Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.69Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
7.69Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.69Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
7.69Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
7.69Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
7.69Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AS7Psilocin9AS7-5-HT2A-Psilocin
7.69Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
7.69Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.69Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.69Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
7.69Consensusneurotensin_offOrthosteric Ligandnts1_off
7.69Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
7.41Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
7.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
7.41Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
7.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
7.41Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
7.41Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.41Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
7.41Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.41Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.41Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
7.41Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
7.41Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
7.41Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
7.41Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
7.41Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
7.41Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
7.41Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
7.41Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
7.41Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
7.41Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
7.41Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
7.41Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
7.41Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.41Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
7.41Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.14Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
7.14Single6A94Zotepine6A94-5-HT2A-Zotepine
7.14Single6TPKRetosiban6TPK-OT-Retosiban
7.14Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
7.14Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
7.14Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
7.14Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
7.14Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
7.14Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
7.14Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
7.14Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
7.14Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
7.14Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
7.14Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
7.14Single9ARXSerotonin9ARX-5-HT2A-Serotonin
7.14Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.14Consensusvasop-oxy_offOrthosteric Ligandot_off
6.90Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
6.90Single4DAJTiotropium4DAJ-M3-Tiotropium
6.90Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
6.90Single5DSGTiotropium5DSG-M4-Tiotropium
6.90Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
6.90Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
6.90Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
6.90Single6IIVDaltroban6IIV-TXA2-Daltroban
6.90Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.90Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
6.90Single8X64Desloratadine8X64-H1-Desloratadine
6.90Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
6.90Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
6.90Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
6.90Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
6.90Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
6.67Single6HLPNetupitant6HLP-NK1-Netupitant
6.67Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.67Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
6.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
6.67Single8ZMFA1L108ZMF-5-HT2C-A1L10
6.67Single9HC04YI9HC0-mGlu5-4YI
6.67Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
6.45Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
6.45Single7P2L4YI7P2L-mGlu5-4YI
6.45Single8EA0Iperoxo8EA0-M3-Iperoxo
6.45Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
6.45Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
6.45Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
6.45Single9AS9RS130-1809AS9-5-HT2A-RS130-180
6.45Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
6.25Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
6.25Single6IIURamatroban6IIU-TXA2-Ramatroban
6.25Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
6.25Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
6.25Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
6.06Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
6.06Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
5.88Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6D35Cholesterol6D35-SMO-Cholesterol
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTTCa7DTT-CaS-Ca-Ca
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTUTryptophan7DTU-CaS-Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.00Single7XW7K1-707XW7-TSH-K1-70
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8WVXNorrin8WVX-LGR4-Norrin
5.00Single8WVYNorrin8WVY-LGR4-Norrin
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.00Single9KHHNorrin9KHH-LGR4-Norrin
5.00Single9S37NB219S37-LGR4-NB21
5.00Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.76Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.76Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.55Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.55Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.35Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.35Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.35Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.35Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5L7DCholesterol5L7D-SMO-Cholesterol
4.17Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.17Single8HS2Fab0468HS2-GPR20-Fab046
4.17Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.00Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
4.00Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
4.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
4.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
4.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
4.00Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
4.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
4.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
4.00Consensussensory_onOrthosteric Ligandopsins_on
3.85Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.85Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
3.85Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
3.85Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
3.85Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
3.85Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
3.85Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
3.85Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Consensusgi_sensoryOrthosteric Ligandgi_opsins
3.85Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.85Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.85Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.70Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
3.70Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.70Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.70Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
3.70Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.57Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
3.45Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.45Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
3.45Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8Y73MPAM-158Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
3.23Single5CGCHTL142425CGC-mGlu5-HTL14242
3.23Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
3.23Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.23Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
3.12Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
3.12Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
3.12Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
3.12Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
3.03Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
2.94Single5CGDHTL142425CGD-mGlu5-HTL14242
2.94Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
2.86Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
2.78Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
2.78Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.78Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.63Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.56Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.38Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
p2y1_on_gp 7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
p2y10_on_gp 8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
p2y12_on_gp 7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
Net Summary
Imin 2.57667
Number of Linked Nodes 983
Number of Links 1217
Number of Hubs 207
Number of Links mediated by Hubs 771
Number of Communities 26
Number of Nodes involved in Communities 253
Number of Links involved in Communities 388
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 2704957
Length Of Smallest Path 3
Average Path Length 38.2246
Length of Longest Path 68
Minimum Path Strength 0.515
Average Path Strength 5.49084
Maximum Path Strength 17.92
Minimum Path Correlation 0.7
Average Path Correlation 0.979753
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.53846
Average % Of Corr. Nodes 30.271
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.0359
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
p2y_off_on_gpp2y_on_gpp2y_off
This network is also present in following consensuses:
IdComponents
nucleotide_on_gpadenosine_on_gp
p2y_on_gp



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