Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.02665
2A:A:L37 5.9275419
3A:A:F196 7.9925467
4A:A:F199 6.58515
5A:A:Q204 4.365489
6A:A:R208 5.0425419
7A:A:K210 6.89489
8A:A:W211 5.046509
9A:A:H213 4.75418
10A:A:F215 6.57419
11A:A:I221 4.4025418
12A:A:F223 6.0025409
13A:A:Y230 13.54254148
14A:A:I253 4.48418
15A:A:F267 4.872867199
16A:A:K270 5.7985119
17A:A:L273 4.944116
18A:A:L283 9.605407
19A:A:C286 8.0654146
20A:A:Y287 10.255147
21A:A:Y290 10.5775407
22A:A:Y296 4.745234
23A:A:Y302 11.074146
24A:A:T316 7.5454223
25A:A:Y320 4.3054157
26A:A:T324 7.37754199
27A:A:F336 5.09568
28B:B:L14 4.4025408
29B:B:L30 5.475405
30B:B:T34 4.095405
31B:B:R48 10.11754247
32B:B:H54 7.22167659
33B:B:Y59 8.708518
34B:B:M61 4.3275406
35B:B:W63 5.144557
36B:B:D76 6.0625459
37B:B:K78 5.0775408
38B:B:W82 8.33714759
39B:B:N88 5.5525407
40B:B:K89 7.89409
41B:B:H91 5.9405
42B:B:I93 5.02407
43B:B:W99 6.705619
44B:B:Y124 6.424506
45B:B:E130 6.5425403
46B:B:L139 4.78409
47B:B:H142 7.364599
48B:B:Y145 4.87222988
49B:B:F151 4.7975409
50B:B:W169 7.945698
51B:B:F180 8.85427
52B:B:D186 4.9275489
53B:B:V187 4.55429
54B:B:M188 5.8025488
55B:B:L192 4.735425
56B:B:F199 6.808529
57B:B:D205 6.495429
58B:B:K209 10.715426
59B:B:W211 9.936528
60B:B:Q220 8.7437
61B:B:F222 7.88538
62B:B:H225 9.666539
63B:B:I232 5.1625408
64B:B:F234 4.232535
65B:B:F235 5.631676126
66B:B:P236 5.66754127
67B:B:F241 8.445436
68B:B:T243 5.6625438
69B:B:R251 12.64438
70B:B:F253 7.8825436
71B:B:D258 7.59537
72B:B:Y264 6.248505
73B:B:C271 5.87754135
74B:B:F278 5.6125127
75B:B:R283 7.94479
76B:B:L284 3.6175405
77B:B:Y289 6.917137
78B:B:N295 7.4354136
79B:B:W297 5.78254138
80B:B:D298 8.7825479
81B:B:K301 5.675475
82B:B:R304 7.0054135
83B:B:H311 8.0825109
84B:B:W332 11.81619
85B:B:D333 8.4654109
86B:B:L336 4.362557
87B:B:K337 6.3265106
88B:B:W339 8.696109
89G:G:Y40 7.7354126
90G:G:D48 6.33579
91G:G:L51 4.076576
92L:L:W14 8.535640
93L:L:Y17 14.8985160
94L:L:R20 7.24840
95L:L:Y21 9.745440
96R:R:V48 5.554179
97R:R:R58 4.26254177
98R:R:Y64 5.795407
99R:R:F75 5.74506
100R:R:R79 7.155406
101R:R:Y99 9.17167643
102R:R:Y106 7.932547
103R:R:F107 4.96646
104R:R:F112 7.7145217
105R:R:L113 4.84188
106R:R:E119 7.75754209
107R:R:R120 5.9075409
108R:R:L125 5.1554277
109R:R:Y130 8.784207
110R:R:R134 6.411676209
111R:R:W147 7.42754219
112R:R:E157 8.688544
113R:R:D177 7.19444
114R:R:I218 3.76508
115R:R:F232 6.7925445
116R:R:F236 5.9525444
117R:R:F237 6.73143745
118R:R:F239 8.81254164
119R:R:L240 6.5575444
120R:R:W241 7.41443
121R:R:V253 4.7054164
122R:R:N264 5.55254189
123R:R:Y272 4.9856189
124R:R:F273 9.14754177
125R:R:F274 4.24177
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I93 B:B:P94 14.70923.39YesNo075
2B:B:K78 B:B:P94 14.6055.02YesNo085
3R:R:S123 R:R:Y130 19.94287.63NoYes087
4A:A:N347 R:R:S123 88.06427.45NoNo088
5A:A:I343 A:A:N347 88.40744.25NoNo078
6A:A:I343 A:A:V339 44.72593.07NoNo078
7A:A:V339 A:A:V34 44.18094.81NoYes685
8A:A:L36 A:A:V34 90.32644.47NoYes075
9A:A:I222 A:A:L36 92.48022.85NoNo077
10A:A:F267 A:A:I222 92.60315.02YesNo097
11A:A:F267 A:A:T324 93.88476.49YesYes1999
12A:A:N269 A:A:T324 95.07422.92NoYes099
13A:A:K270 A:A:N269 95.19262.8YesNo099
14A:A:D272 A:A:K270 95.41245.53NoYes1199
15A:A:C325 A:A:D272 97.82383.11NoNo079
16A:A:C325 A:A:K271 98.279312.93NoNo075
17A:A:K271 A:A:Y296 98.39263.58NoYes054
18A:A:F274 A:A:Y296 98.94084.13NoYes094
19A:A:F274 A:A:L227 99.05237.31NoNo097
20A:A:I303 A:A:L227 99.68814.28NoNo077
21A:A:I303 A:A:M243 99.79884.37NoNo078
22A:A:M243 A:A:Y230 50.14757.18NoYes1488
23A:A:Y230 A:A:Y287 49.84979.93YesYes1487
24A:A:M247 A:A:Y287 1005.99NoYes067
25A:A:F307 A:A:M247 99.95524.98NoNo086
26A:A:F307 A:A:V225 68.24796.55NoNo087
27A:A:F223 A:A:V225 67.8215.24YesNo097
28A:A:F223 A:A:L249 67.28696.09YesNo099
29A:A:L249 A:A:R208 66.29243.64NoYes199
30A:A:R208 A:A:W211 66.06935YesYes099
31A:A:W211 B:B:Y145 67.87032.89YesYes098
32B:B:G162 B:B:Y145 29.71228.69NoYes098
33B:B:G162 B:B:S161 29.50823.71NoNo099
34B:B:H142 B:B:S161 29.085215.34YesNo999
35B:B:H142 B:B:L146 20.46123.86YesNo997
36B:B:C121 B:B:L146 20.28483.17NoNo087
37B:B:C121 B:B:C149 20.54581.82NoNo088
38B:B:C149 B:B:T102 20.17225.07NoNo088
39B:B:G115 B:B:T102 19.99081.82NoNo098
40B:B:C114 B:B:G115 19.64393.92NoNo089
41B:B:C114 B:B:L79 19.31417.94NoNo087
42B:B:I93 B:B:L79 16.58165.71YesNo077
43A:A:I343 R:R:R131 44.024512.53NoNo076
44A:A:V34 R:R:R131 44.18145.23YesNo056
45A:A:C286 A:A:M243 49.76173.24YesNo1468
46A:A:C286 A:A:Y287 49.85345.38YesYes1467
47A:A:F215 A:A:L37 30.715610.96YesYes199
48A:A:I221 A:A:L37 30.71542.85YesYes189
49A:A:F215 B:B:W99 31.00777.02YesYes199
50B:B:Q75 B:B:W99 32.07235.48NoYes199
51B:B:Q75 B:B:Y59 31.016115.78NoYes198
52B:B:W332 B:B:Y59 29.64418.68YesYes198
53B:B:R314 B:B:W332 25.608421.99NoYes089
54B:B:D290 B:B:R314 25.469520.25NoNo068
55B:B:D290 B:B:T274 15.13884.34NoNo068
56B:B:S275 B:B:T274 14.98523.2NoNo088
57B:B:L318 B:B:S275 14.84747.51NoNo068
58B:B:L286 B:B:L318 14.74354.15NoNo076
59B:B:L286 B:B:V296 14.36087.45NoNo075
60B:B:L284 B:B:V296 14.12954.47YesNo055
61G:G:D48 G:G:P49 12.9864.83YesNo097
62B:B:M325 G:G:P49 11.5355.03NoNo057
63A:A:K210 B:B:Y145 25.85313.58YesYes898
64B:B:M188 B:B:Y145 13.01934.79YesYes888
65A:A:K210 B:B:D228 12.86688.3YesNo099
66A:A:K210 B:B:N230 12.86065.6YesNo899
67B:B:M188 B:B:N230 12.91342.8YesNo889
68A:A:I221 A:A:I264 31.74292.94YesNo186
69A:A:F250 A:A:I264 30.78463.77NoNo196
70A:A:C351 R:R:R120 69.55532.79NoYes049
71A:A:C351 R:R:S123 69.91043.44NoNo048
72B:B:I18 B:B:R22 12.82622.51NoNo076
73B:B:I18 G:G:A23 11.8451.62NoNo078
74B:B:Q17 G:G:A23 11.3541.52NoNo048
75B:B:D258 B:B:R22 14.46963.57YesNo076
76B:B:D186 B:B:Y145 10.3166.9YesYes898
77B:B:C204 B:B:G185 10.79921.96NoNo075
78B:B:D205 B:B:G185 10.41845.03YesNo095
79B:B:D258 B:B:F222 15.76958.36YesYes378
80B:B:F222 B:B:F253 18.96786.43YesYes386
81B:B:H225 B:B:S245 37.035615.34YesNo099
82B:B:H225 B:B:R251 25.09118.05YesYes398
83B:B:D228 B:B:D246 13.94089.31NoNo099
84B:B:D246 B:B:S227 38.8872.94NoNo096
85B:B:D246 B:B:N230 25.44468.08NoNo099
86B:B:S227 B:B:S245 37.47453.26NoNo069
87B:B:C271 B:B:D290 10.93856.22YesNo056
88R:R:R120 R:R:Y272 60.96627.2YesYes099
89R:R:L113 R:R:Y272 54.62594.69YesYes1889
90R:R:F225 R:R:L113 54.07474.87NoYes088
91R:R:F225 R:R:L110 52.97916.09NoNo087
92R:R:L110 R:R:Y106 52.613510.55NoYes077
93R:R:F107 R:R:Y106 24.4455.16YesYes467
94R:R:F107 R:R:F237 12.54023.22YesYes465
95R:R:F75 R:R:Y106 21.85786.19YesYes067
96R:R:F75 R:R:S265 13.41746.61YesNo069
97R:R:L146 R:R:V142 10.20344.47NoNo076
98B:B:F253 B:B:R251 22.66516.41YesYes368
99B:B:C271 B:B:Y289 10.03284.03YesYes1357
100A:A:F250 A:A:F307 31.71479.65NoNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:P11 R:R:W241 6.76 4 No Yes 0 3 0 1
L:L:W14 R:R:L240 10.25 4 Yes Yes 0 4 0 1
L:L:W14 R:R:W241 9.37 4 Yes Yes 0 3 0 1
L:L:Y17 R:R:L249 7.03 16 Yes No 0 3 0 1
L:L:Y17 R:R:F250 27.85 16 Yes No 0 3 0 1
L:L:Y17 R:R:H254 17.42 16 Yes No 0 1 0 1
L:L:R20 R:R:Y99 19.55 4 Yes Yes 0 3 0 1
L:L:R20 R:R:E157 11.63 4 Yes Yes 0 4 0 1
L:L:R20 R:R:Q174 3.5 4 Yes No 0 3 0 1
L:L:R20 R:R:D177 3.57 4 Yes Yes 0 4 0 1
L:L:R20 R:R:F236 4.28 4 Yes Yes 0 4 0 1
L:L:R20 R:R:F237 6.41 4 Yes Yes 0 5 0 1
L:L:R20 R:R:L240 4.86 4 Yes Yes 0 4 0 1
L:L:Y21 R:R:Y99 5.96 4 Yes Yes 0 3 0 1
L:L:Y21 R:R:E157 13.47 4 Yes Yes 0 4 0 1
L:L:Y21 R:R:W158 15.43 4 Yes No 0 4 0 1
R:R:P100 R:R:Y99 5.56 0 No Yes 4 3 2 1
R:R:M103 R:R:Y99 11.97 4 No Yes 2 3 2 1
R:R:E157 R:R:Y99 7.86 4 Yes Yes 4 3 1 1
R:R:F236 R:R:Y99 4.13 4 Yes Yes 4 3 1 1
R:R:F107 R:R:M103 3.73 4 Yes No 6 2 2 2
R:R:F237 R:R:M103 4.98 4 Yes No 5 2 1 2
R:R:F107 R:R:R153 8.55 4 Yes No 6 4 2 2
R:R:F107 R:R:F237 3.22 4 Yes Yes 6 5 2 1
R:R:E157 R:R:R153 5.82 4 Yes No 4 4 1 2
R:R:R153 R:R:T180 6.47 0 No No 4 5 2 2
R:R:E157 R:R:F237 4.66 4 Yes Yes 4 5 1 1
R:R:Q174 R:R:S176 2.89 0 No No 3 3 1 2
R:R:D177 R:R:F237 11.94 4 Yes Yes 4 5 1 1
R:R:D177 R:R:L240 5.43 4 Yes Yes 4 4 1 1
R:R:D177 R:R:W241 7.82 4 Yes Yes 4 3 1 1
R:R:F237 R:R:T180 5.19 4 Yes No 5 5 1 2
R:R:F236 R:R:Q235 4.68 4 Yes No 4 3 1 2
R:R:Q235 R:R:V253 4.3 0 No Yes 3 4 2 2
R:R:F236 R:R:F237 10.72 4 Yes Yes 4 5 1 1
R:R:F239 R:R:L249 4.87 16 Yes No 4 3 2 1
R:R:F239 R:R:V253 5.24 16 Yes Yes 4 4 2 2
R:R:L240 R:R:W241 5.69 4 Yes Yes 4 3 1 1
R:R:L249 R:R:V253 4.47 16 No Yes 3 4 1 2
R:R:F250 R:R:H254 13.58 16 No No 3 1 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
52.63Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
46.67Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
41.18Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
40.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
38.89Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
33.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
33.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
31.58Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
30.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
29.41Single7VV6C48/807VV6-MRGPRX2-C48/80
27.27Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.32Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
26.32Single6Z4SSR486926Z4S-NTS1-SR48692
26.32Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
26.09Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
25.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
25.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
24.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.81Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
23.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
23.81Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
23.81Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
23.81Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
23.81Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.53Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
23.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
23.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
23.53Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
23.53Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
23.53Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
22.73Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
22.73Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
22.73Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
22.22Single6TPKRetosiban6TPK-OT-Retosiban
22.22Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
22.22Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
22.22Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.22Consensusvasop-oxy_offOrthosteric Ligandot_off
21.74Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
21.05Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
21.05Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
21.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.83Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.83Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.83Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
20.83Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
20.83Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.83Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single8WKYPG-9348WKY-MC4-PG-934
20.83Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
20.83Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.83Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
20.83Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.69Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
20.69Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
20.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
20.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
20.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
20.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
20.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
20.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
20.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
19.35Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
19.35Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
19.23Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
19.23Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
19.23Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
19.23Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
19.23Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
19.23Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.05Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
19.05Single4BV0Neurotensin4BV0-NTS1-Neurotensin
19.05Single5TZRMK86665TZR-FFA1-MK8666
19.05Single6E59L-7607356E59-NK1-L-760735
19.05Single6J20Aprepitant6J20-NK1-Aprepitant
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
19.05Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
19.05Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
19.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
19.05Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
19.05Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
19.05Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
19.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
19.05Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.05Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
19.05Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
19.05Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
19.05Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
19.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.05Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
19.05Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
19.05Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
19.05Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Consensuslpa_onOrthosteric Ligandlpa1_on
19.05Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
19.05Consensusneurotensin_onOrthosteric Ligandnts1_on
19.05Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.75Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
18.75Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.75Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
18.52Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.52Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
18.52Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
18.52Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
18.18Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
18.18Single4PY02MeSATP4PY0-P2Y12-2MeSATP
18.18Single4RWADIPP-NH24RWA-δ-DIPP-NH2
18.18Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.18Single4XESNeurotensin4XES-NTS1-Neurotensin
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.18Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.18Single7YITNalfurafine7YIT-κ-Nalfurafine
18.18Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
18.18Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
18.18Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.18Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
18.18Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.86Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.86Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.86Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.65Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.65Single6HLLCP999946HLL-NK1-CP99994
17.65Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.65Single7UL2SR486927UL2-NTS1-SR48692-Na
17.65Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.65Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.65Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
17.65Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
17.65Consensusneurotensin_offOrthosteric Ligandnts1_off
17.65Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
17.39Single4BUONeurotensin4BUO-NTS1-Neurotensin
17.39Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
17.39Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
17.39Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
17.39Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
17.39Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
17.39Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
17.39Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
17.39Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.39Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
17.39Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
17.39Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
17.39Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
17.24Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.24Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Single3PWHZM-2413853PWH-A2A-ZM-241385
16.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
16.67Single5WS3EMPA5WS3-OX2-EMPA
16.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
16.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6TODEMPA6TOD-OX1-EMPA-Na
16.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.67Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.67Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
16.67Single7F8ULintitript7F8U-CCKA-Lintitript
16.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.67Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
16.67Single7XRRLemborexant7XRR-OX2-Lemborexant
16.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
16.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
16.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.67Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.67Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
16.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.67Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
16.67Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
16.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
16.13Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.13Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
16.00Single8IEBA1LYA8IEB-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
16.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
15.79Single3REYXAC3REY-A2A-XAC
15.79Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.79Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
15.79Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.79Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.79Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.79Single5JTBZM-2413855JTB-A2A-ZM-241385
15.79Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.79Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.79Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.79Single5UVIZM-2413855UVI-A2A-ZM-241385
15.79Single6AQFZM-2413856AQF-A2A-ZM-241385
15.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.79Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.79Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.79Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.79Single6TPNHTL66416TPN-OX2-HTL6641
15.79Single6V9SGTPL114036V9S-OX1-GTPL11403
15.79Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.79Single6ZINSR486926ZIN-NTS1-SR48692
15.79Single7AROLUF58337ARO-A2A-LUF5833-Na
15.79Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.79Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.79Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
15.79Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.79Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.79Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
15.79Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
15.79Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.79Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
15.79Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
15.79Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusa2_offOrthosteric Liganda2a_off
15.79Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.79Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
15.79Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.38Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
15.38Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
15.38Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
15.38Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
15.38Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
15.38Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
15.38Single8IEBA1LYA8IEB-GPR156-A1LYA
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.38Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
15.38Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.38Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.38Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
15.38Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
15.38Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
15.15Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
15.15Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
15.15Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
15.00Single3EMLZM-2413853EML-A2A-ZM-241385
15.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.00Single5UENDU1725UEN-A1-DU172
15.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
15.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
15.00Single6S0LZM-2413856S0L-A2A-ZM-241385
15.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
15.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.00Single7PYRPSB-21157PYR-A2A-PSB-2115
15.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
15.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
15.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.00Single8CU6LJ-45178CU6-A2A-LJ-4517
15.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
15.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
15.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
15.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.00Consensusa3_onOrthosteric Liganda3a_on
15.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
15.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
14.81Single3OE0CVX153OE0-CXCR4-CVX15
14.81Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
14.81Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.81Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
14.81Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
14.81Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
14.81Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
14.71Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
14.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
14.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5N2RPSB-365N2R-A2A-PSB-36-Na
14.29Single5N2SPSB365N2S-A1-PSB36
14.29Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
14.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
14.29Single5WQCEMPA5WQC-OX2-EMPA
14.29Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
14.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
14.29Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
14.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
14.29Single6TP6Filorexant6TP6-OX1-Filorexant
14.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
14.29Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
14.29Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
14.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
14.29Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
14.29Single7W41PD1762527W41-BB2-PD176252
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
14.29Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
14.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
14.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.29Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
14.29Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.29Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8QOTNanobody-E8QOT-μ-Nanobody-E
14.29Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
14.29Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
14.29Consensusa3_on_gpOrthosteric Liganda3a_on_gp
14.29Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
14.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.29Consensusbombesin_offOrthosteric Ligandbb2_off
14.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
14.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
14.29Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
14.29Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
13.79Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.79Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
13.79Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
13.64Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
13.64Single5XRAAM115425XRA-CB1-AM11542
13.64Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
13.64Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
13.64Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
13.64Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.64Single7FEECP559407FEE-CB1-CP55940-ZCZ011
13.64Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
13.64Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
13.64Single7PX4PSB-21137PX4-A2A-PSB-2113
13.64Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
13.64Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
13.64Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.64Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
13.64Single8E0GBU728E0G-μ-BU72
13.64Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.64Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
13.64Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
13.64Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
13.64Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
13.64Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
13.64Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
13.64Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.64Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.64Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusa2_onOrthosteric Liganda2b_on
13.64Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.64Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.64Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.64Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
13.04Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
13.04Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
13.04Single6KQICP559406KQI-CB1-CP55940-Org27569
13.04Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.04Single6YVRNTS8-136YVR-NTS1-NTS8-13
13.04Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.04Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
13.04Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.04Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.04Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
13.04Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.04Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
13.04Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
13.04Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single8XWSCXCL58XWS-CXCR2-CXCL5
13.04Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
13.04Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
13.04Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.04Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
13.04Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
13.04Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
13.04Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.04Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
13.04Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
13.04Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.04Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
13.04Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
13.04Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
13.04Consensuslpa_offOrthosteric Ligandlpa1_off
13.04Consensuslpl_offOrthosteric Ligands1p_off lpa_off
13.04Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.04Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
13.04Consensusorexin_onOrthosteric Ligandox2_on
13.04Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
12.90Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
12.90Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
12.90Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.90Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
12.90Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
12.50Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
12.50Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
12.50Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
12.50Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
12.50Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.50Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.50Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
12.50Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.50Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
12.50Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
12.50Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
12.50Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
12.50Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
12.50Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50Consensuscck_onOrthosteric Ligandccka_on cckb_on
12.50Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
12.50Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.50Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.50Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
12.12Single6IGKEndothelin-36IGK-ETB-Endothelin-3
12.12Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.12Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.12Consensusbombesin_onOrthosteric Ligandbb2_on
12.12Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
12.12Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.12Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.00Single3NY9ICI118-5513NY9-β2-ICI118-551
12.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
12.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
12.00Single6PT3DPI-2876PT3-δ-DPI-287
12.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
12.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
12.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
12.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
12.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single3UZAGTPL92363UZA-A2A-GTPL9236
11.76Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.76Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.54Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.54Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.54Single7F8XNN90567F8X-CCKA-NN9056
11.54Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
11.54Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.54Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
11.54Single8IEIA1LYA8IEI-GPR156-A1LYA
11.54Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
11.54Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.54Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
11.54Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
11.54Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
11.54Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
11.54Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
11.54Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.54Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.54Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
11.54Consensussomatostatin_offOrthosteric Ligandsst2_off
11.54Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.11Single3QAKUK-4320973QAK-A2A-UK-432097
11.11Single6HLOAprepitant6HLO-NK1-Aprepitant
11.11Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.11Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
11.11Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
11.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.11Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.11Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.11Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.71Single5WF5UK-4320975WF5-A2A-UK-432097
10.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
10.71Single6PT2KGCHM076PT2-δ-KGCHM07
10.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.71Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
10.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
10.71Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.71Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.71Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
10.71Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
10.71Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.71Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.71Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
10.71Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.71Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.53Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.53Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6B73MP11046B73-κ-MP1104
10.53Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.53Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.53Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.53Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.53Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.53Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
10.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
10.53Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.53Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
10.53Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.53Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.53Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.53Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.34Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.34Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
10.34Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
10.34Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
10.34Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
10.34Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.34Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.34Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.34Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
10.34Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
10.26Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
10.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
10.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.00Single6IQLL7458706IQL-D4-L745870
10.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
10.00Single6TPGEMPA6TPG-OX2-EMPA
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
10.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
10.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
10.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
10.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
10.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
10.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
10.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
10.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8ZRTET-18ZRT-ETB-ET-1
10.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
10.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
10.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
10.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
9.68Single7SK3CXCL127SK3-ACKR3-CXCL12
9.68Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.68Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
9.68Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.68Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
9.68Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
9.68Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
9.68Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
9.52Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.52Single4EJ4Naltrindole4EJ4-δ-Naltrindole
9.52Single4QIMANTA XV4QIM-SMO-ANTA XV
9.52Single4YAYZD-71554YAY-AT1-ZD-7155
9.52Single5DHGC-355DHG-NOP-C-35
9.52Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
9.52Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
9.52Single5T04Neurotensin5T04-NTS1-Neurotensin
9.52Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
9.52Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
9.52Single6PS1Timolol6PS1-β2-Timolol
9.52Single6TOTLemborexant6TOT-OX1-Lemborexant
9.52Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.52Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
9.52Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
9.52Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
9.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.52Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.52Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
9.52Single7UL4Alvimopan7UL4-μ-Alvimopan
9.52Single7V3ZCP559407V3Z-CB1-CP55940
9.52Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.52Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
9.52Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
9.52Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.52Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.52Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
9.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.52Single8RLNLUF58348RLN-A2A-LUF5834
9.52Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.52Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
9.52Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.52Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
9.52Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.52Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.52Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.52Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
9.52Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.52Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.52Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
9.38Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
9.38Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.38Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
9.38Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
9.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
9.38Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
9.09Single5C1MBU725C1M-μ-BU72
9.09Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
9.09Single5XPRBosentan5XPR-ETB-Bosentan
9.09Single6IGLIRL16206IGL-ETB-IRL1620
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
9.09Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.09Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.09Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.09Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.09Single7C61Ergotamine7C61-5-HT1B-Ergotamine
9.09Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
9.09Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
9.09Single7WC6LSD7WC6-5-HT2A-LSD
9.09Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
9.09Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
9.09Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.09Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.09Single8IY6Endothelin-18IY6-ETB-Endothelin-1
9.09Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
9.09Single8JXSPF-61428JXS-D1-PF-6142
9.09Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
9.09Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
9.09Single8S4DCMF-0198S4D-Apelin-CMF-019
9.09Single8TF5Oleic acid8TF5-GPR6-Oleic acid
9.09Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
9.09Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
9.09Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
9.09Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
9.09Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
9.09Consensusbradykinin_onOrthosteric Ligandbk2_on
9.09Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
9.09Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.09Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.09Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
9.09Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.09Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
8.82Single5GLHEndothelin-15GLH-ETB-Endothelin-1
8.70Single3P0GBI1671073P0G-β2-BI167107
8.70Single4DJHJDTic4DJH-κ-JDTic
8.70Single5V56TC1145V56-SMO-TC114
8.70Single5XR8AM8415XR8-CB1-AM841
8.70Single6H7JIsoprenaline6H7J-β1-Isoprenaline
8.70Single6J21Aprepitant6J21-NK1-Aprepitant
8.70Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
8.70Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.70Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
8.70Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
8.70Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.70Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
8.70Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
8.70Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.70Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
8.70Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.70Single7TUYGSK682753A7TUY-GPR183-GSK682753A
8.70Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
8.70Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.70Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
8.70Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
8.70Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.70Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
8.70Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.70Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
8.70Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
8.70Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
8.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.70Single8XVLZibotentan8XVL-ETA-Zibotentan
8.70Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.70Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
8.70Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
8.70Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.70Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
8.70Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
8.70Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
8.70Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
8.70Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.70Consensusrelaxin_onOrthosteric Ligandrxfp4_on
8.70Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
8.70Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.70Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.57Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
8.57Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
8.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
8.33Single4LDEBI1671074LDE-β2-BI167107
8.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
8.33Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
8.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
8.33Single6MXTSalmeterol6MXT-β2-Salmeterol
8.33Single6OS2TRV0266OS2-AT1-TRV026
8.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
8.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.33Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
8.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
8.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
8.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
8.33Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
8.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.33Single8JJ8Formoterol8JJ8-β2-Formoterol
8.33Single8JJLOlodaterol8JJL-β2-Olodaterol
8.33Single8JWY2-1188JWY-A2A-2-118
8.33Single8JWZAB9288JWZ-A2A-AB928-Na
8.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
8.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
8.33Single8XQJJN2418XQJ-Apelin-JN241
8.33Single8XWACXCL18XWA-CXCR2-CXCL1
8.33Single8XWMCXCL68XWM-CXCR2-CXCL6
8.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.33Single8XYIVUF106618XYI-CXCR3-VUF10661
8.33Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
8.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
8.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
8.33Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.33Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.33Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.33Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
8.33Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
8.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.11Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
8.11Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.11Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
8.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.00Single5X93K-87945X93-ETB-K-8794
8.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
8.00Single6K1QIRL25006K1Q-ETB-IRL2500
8.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
8.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
8.00Single7EZCUKA7EZC-A2A-UKA
8.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
8.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
8.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
8.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00Single8XVUCXCL28XVU-CXCR2-CXCL2
8.00Single8XWFCXCL38XWF-CXCR2-CXCL3
8.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
8.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
8.00Consensuschemerin_onOrthosteric Ligandcml1_on
8.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
8.00Consensusendothelin_offOrthosteric Ligandetb_off
8.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
8.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.69Single4UG2CGS216804UG2-A2A-CGS21680
7.69Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
7.69Single5WF6UK-4320975WF6-A2A-UK-432097
7.69Single5ZTYAM102575ZTY-CB2-AM10257
7.69Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
7.69Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
7.69Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
7.69Single7XN9L-054,5227XN9-SST2-L-054,522
7.69Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
7.69Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
7.69Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
7.69Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.69Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
7.69Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
7.69Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
7.69Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
7.69Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
7.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
7.69Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
7.69Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
7.69Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.69Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
7.41Single4IARErgotamine4IAR-5-HT1B-Ergotamine
7.41Single4XT1Fractalkine4XT1-US28-Fractalkine
7.41Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
7.41Single7QA8Peptide7QA8-STE2-Peptide
7.41Single7QA8Peptide7QA8-STE2-Peptide
7.41Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
7.41Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
7.41Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7.41Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
7.41Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.41Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
7.41Single8WDTphotoNECA8WDT-A2A-photoNECA
7.41Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41Single8XWNCXCL88XWN-CXCR2-CXCL8
7.41Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.41Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
7.41Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.41Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.14Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.14Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
7.14Single7SK5CXCL127SK5-ACKR3-CXCL12
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
7.14Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
7.14Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
7.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
7.14Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
7.14Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.90Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.90Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
6.90Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
6.90Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.90Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
6.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.67Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
6.67Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
6.67Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
6.67Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.67Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.67Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
6.67Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
6.67Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
6.67Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Consensusvasop-oxy_onOrthosteric Ligandv2_on
6.67Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
6.45Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
6.45Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
6.45Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.45Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.45Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
6.45Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
6.45Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
6.45Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.45Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
6.45Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
6.25Single4XT3Fractalkine4XT3-US28-Fractalkine
6.25Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
6.25Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.25Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
6.25Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.25Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
6.25Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.25Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
6.25Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.25Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
6.25Single8PWNTheophylline8PWN-A2A-Theophylline
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.25Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
6.25Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
6.06Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
6.06Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.06Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.06Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
6.06Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
6.06Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.06Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
6.06Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
6.06Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.06Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
5.88Single3OE8IT1t3OE8-CXCR4-IT1t
5.88Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.88Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.88Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
5.88Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
5.88Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
5.88Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
5.88Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
5.88Consensusendothelin_onOrthosteric Ligandetb_on eta_on
5.88Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off
5.71Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
5.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
5.71Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
5.71Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
5.71Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
5.56Single3OE6IT1t3OE6-CXCR4-IT1t
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.56Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
5.56Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.56Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.56Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.56Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
5.56Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
5.56Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.56Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.56Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.56Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.56Consensus5ht2_onOrthosteric Ligand5ht2b_on
5.56Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
5.56Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
5.56Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.56Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.41Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
5.41Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
5.41Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
5.41Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single3OE9IT1t3OE9-CXCR4-IT1t
5.26Single3PBLEticlopride3PBL-D3-Eticlopride
5.26Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.26Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.26Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
5.26Single7SRQLSD7SRQ-5-HT2B-LSD
5.26Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.26Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.26Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
5.26Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
5.26Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.26Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
5.26Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
5.26Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.26Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.26Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.26Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.26Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.26Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
5.26Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.26Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
5.26Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.26Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.26Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
5.26Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.26Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
5.00Single3ODUIT1t3ODU-CXCR4-IT1t
5.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single6AKXA4R6AKX-CCR5-A4R
5.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
5.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
5.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
5.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
5.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
5.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
5.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
5.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
5.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
5.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
5.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.00Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
5.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
5.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
5.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.00Single8IWESpermidine8IWE-TA9-Spermidine
5.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
5.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
5.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
5.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
5.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
5.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
5.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
5.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
5.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
5.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
5.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
5.00Consensusangiotensin_offOrthosteric Ligandat1_off
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
5.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Single2YDOAdenosine2YDO-A2A-Adenosine
4.76Single3RZECidoxepin3RZE-H1-Cidoxepin
4.76Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.76Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
4.76Single4MBSMaraviroc4MBS-CCR5-Maraviroc
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
4.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
4.76Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
4.76Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
4.76Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
4.76Single6PS0S-Carazolol6PS0-β2-S-Carazolol
4.76Single6PS4ICI118-5516PS4-β2-ICI118-551
4.76Single6PS5S-Propranolol6PS5-β2-S-Propranolol
4.76Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.76Single6VI4JDTic6VI4-κ-JDTic
4.76Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
4.76Single6ZG9GSK10347026ZG9-M1-GSK1034702
4.76Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
4.76Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
4.76Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
4.76Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
4.76Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
4.76Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
4.76Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
4.76Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
4.76Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
4.76Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7T32ZM-2413857T32-A2A-ZM-241385
4.76Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
4.76Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
4.76Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.76Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
4.76Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
4.76Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
4.76Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
4.76Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
4.76Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
4.76Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
4.76Single8IHKAcifran8IHK-HCA3-Acifran
4.76Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
4.76Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
4.76Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
4.76Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
4.76Single8K5CAcipimox8K5C-HCA2-Acipimox
4.76Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
4.76Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
4.76Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
4.76Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.76Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
4.76Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
4.76Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
4.76Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
4.76Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
4.76Consensusalpha1_onOrthosteric Ligandalpha1a_on
4.76Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
4.76Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.76Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.76Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.76Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.76Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.76Consensushca_onOrthosteric Ligandhca2_on
4.76Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.55Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
4.55Single2Y02Carmoterol2Y02-β1-Carmoterol
4.55Single2Y04Salbutamol2Y04-β1-Salbutamol
4.55Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
4.55Single3NY8ICI118-5513NY8-β2-ICI118-551
4.55Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
4.55Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.55Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.55Single4GBRS-Carazolol4GBR-β2-S-Carazolol
4.55Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
4.55Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
4.55Single5DHHSB-6121115DHH-NOP-SB-612111
4.55Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
4.55Single5TGZAM65385TGZ-CB1-AM6538
4.55Single6D27CAY104716D27-DP2-CAY10471
4.55Single6DRXLisuride6DRX-5-HT2B-Lisuride
4.55Single6GPSMK08126GPS-CCR2-MK0812
4.55Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.55Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
4.55Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.55Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
4.55Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
4.55Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.55Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
4.55Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
4.55Single7BU7BI1671077BU7-β1-BI167107
4.55Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
4.55Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
4.55Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.55Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.55Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
4.55Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
4.55Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
4.55Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
4.55Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.55Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
4.55Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.55Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
4.55Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
4.55Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
4.55Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.55Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.55Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.55Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.55Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.55Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
4.55Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
4.55Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
4.55Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
4.55Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
4.55Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
4.55Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
4.55Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
4.55Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.55Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8JJOAlprenolol8JJO-β2-Alprenolol
4.55Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
4.55Single8JXRLSD8JXR-D1-LSD
4.55Single8K5DGSK2560738K5D-HCA2-GSK256073
4.55Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.55Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.55Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8X63Mepyramine8X63-H1-Mepyramine
4.55Single8X64Desloratadine8X64-H1-Desloratadine
4.55Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.55Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
4.55Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
4.55Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
4.55Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
4.55Single9CHXS-Carazolol9CHX-β2-S-Carazolol
4.55Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.55Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.55Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.55Consensus5ht5_onOrthosteric Ligand5ht5a_on
4.55Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.55Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.55Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.55Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
4.55Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
4.55Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
4.55Consensusalpha2_onOrthosteric Ligandalpha2b_on
4.55Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
4.55Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.55Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.55Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.55Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Consensusblt_onOrthosteric Ligandblt1_on
4.55Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
4.55Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.55Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.55Consensusdopamine_offOrthosteric Ligandd2_off d3_off
4.55Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
4.55Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
4.55Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
4.55Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.55Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
4.55Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.55Consensushca_on_gpOrthosteric Ligandhca2_on_gp
4.55Consensushistamine_offOrthosteric Ligandh1_off
4.55Consensusleukotriene_onOrthosteric Ligandblt_on
4.55Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
4.55Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.35Single2RH1S-Carazolol2RH1-β2-S-Carazolol
4.35Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.35Single2YCWS-Carazolol2YCW-β1-S-Carazolol
4.35Single4JKVTaladegib4JKV-SMO-Taladegib
4.35Single5D6LS-Carazolol5D6L-β2-S-Carazolol
4.35Single5JQHS-Carazolol5JQH-β2-S-Carazolol
4.35Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.35Single5TVNLSD5TVN-5-HT2B-LSD
4.35Single6E67BI1671076E67-β2-BI167107-Gs (fused)
4.35Single6GPXMK08126GPX-CCR2-MK0812
4.35Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.35Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
4.35Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.35Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.35Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
4.35Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.35Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
4.35Single6PS6Timolol6PS6-β2-Timolol
4.35Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
4.35Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
4.35Single7C4SS1P7C4S-S1P3-S1P
4.35Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
4.35Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.35Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
4.35Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
4.35Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
4.35Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
4.35Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
4.35Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
4.35Single8ZMFA1L108ZMF-5-HT2C-A1L10
4.35Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
4.35Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
4.35Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
4.35Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.35Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.35Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.35Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
4.35Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.35Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
4.35Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
4.35Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
4.35Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
4.35Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.35Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.35Consensusamine_offonOrthosteric Ligandamine_off amine_on
4.35Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
4.35Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.35Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
4.35Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.35Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.35Consensusblt_offOrthosteric Ligandblt1_off
4.35Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
4.35Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.35Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
4.35Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
4.35Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.35Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
4.17Single2YDVNECA2YDV-A2A-NECA
4.17Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
4.17Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
4.17Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.17Single4UHRCGS216804UHR-A2A-CGS21680
4.17Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.17Single5D5AS-Carazolol5D5A-β2-S-Carazolol
4.17Single5D5BS-Carazolol5D5B-β2-S-Carazolol
4.17Single5G53NECA5G53-A2A-NECA-Gs
4.17Single5V54Methiothepin5V54-5-HT1B-Methiothepin
4.17Single5V57TC1145V57-SMO-TC114
4.17Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.17Single6OS1TRV0266OS1-AT1-TRV026
4.17Single6WGTLSD6WGT-5-HT2A-LSD
4.17Single7B6WCyclazosin7B6W-α1b-Cyclazosin
4.17Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.17Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
4.17Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.17Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.17Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
4.17Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.17Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
4.17Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.17Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
4.17Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
4.17Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.17Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
4.17Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
4.17Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
4.17Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
4.17Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
4.17Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.17Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.17Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
4.17Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.17Single9BJKNAM9BJK-μ-Naloxone-NAM
4.17Consensus5ht1_offOrthosteric Ligand5ht1b_off
4.17Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
4.17Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.17Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.17Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.17Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.17Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.17Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
4.00Single3D4STimolol3D4S-β2-Timolol
4.00Single4AMIBucindolol4AMI-β1-Bucindolol
4.00Single4N4WSANT-14N4W-SMO-SANT-1
4.00Single5X33BIIL2605X33-BLT1-BIIL260
4.00Single6A93Risperidone6A93-5-HT2A-Risperidone
4.00Single6CM4Risperidone6CM4-D2-Risperidone
4.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
4.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
4.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
4.00Single7DFPSpiperone7DFP-D2-Spiperone
4.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
4.00Single7K15MKD0467K15-BLT1-MKD046-Na
4.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
4.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
4.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
4.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
4.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
4.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
4.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
4.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
4.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
4.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
4.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
4.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
4.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
4.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
4.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
3.85Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
3.85Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
3.85Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.85Single6H7LDobutamine6H7L-β1-Dobutamine
3.85Single6IBLArformoterol6IBL-β1-Arformoterol
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.85Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
3.85Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.85Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
3.85Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
3.85Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
3.85Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.85Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.85Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
3.85Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
3.85Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
3.85Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.85Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
3.85Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.85Single8XVJMacitentan8XVJ-ETA-Macitentan
3.85Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.85Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.85Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.85Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.70Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
3.70Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
3.70Single8X5YAstemizole8X5Y-H1-Astemizole
3.70Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.70Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.70Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.57Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
3.57Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
3.57Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
3.57Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
3.57Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
3.57Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
3.45Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
3.45Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
3.45Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.45Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
3.45Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.45Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.45Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.45Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
3.45Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
3.33Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
3.33Consensusangiotensin_onOrthosteric Ligandat1_on
3.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.23Single6JODAngiotensin II6JOD-AT2-Angiotensin II
3.23Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
3.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
3.23Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.23Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.23Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.23Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.23Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
3.23Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.23Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.12Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.12Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
3.12Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
3.12Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
3.03Single6FJ3PTH6FJ3-PTH1-PTH
3.03Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
3.03Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
3.03Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.03Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.94Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.94Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
2.94Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.86Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.86Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.86Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.56Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.50Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1

PDB Summary
PDB 8JGG
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRX1
Species Homo Sapiens
Ligand BAM8-22
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2024-01-10
D.O.I. 10.1038/s41467-023-40705-z
Net Summary
Imin 2.8
Number of Linked Nodes 790
Number of Links 935
Number of Hubs 125
Number of Links mediated by Hubs 465
Number of Communities 28
Number of Nodes involved in Communities 216
Number of Links involved in Communities 292
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 1208020
Length Of Smallest Path 3
Average Path Length 39.2882
Length of Longest Path 72
Minimum Path Strength 1.33
Average Path Strength 5.91495
Maximum Path Strength 22.02
Minimum Path Correlation 0.7
Average Path Correlation 0.978387
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 36.6325
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.5846
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • molecular transducer activity   • binding   • molecular function activator activity   • signaling receptor binding   • signaling receptor activity   • neuropeptide activity   • signaling receptor activator activity   • hormone activity   • protein binding   • molecular function regulator activity   • neuropeptide hormone activity   • signaling receptor regulator activity   • receptor ligand activity   • opioid peptide activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • developmental process   • multicellular organismal process   • cellular developmental process   • ossification   • cell differentiation   • osteoblast differentiation   • response to chemical   • response to epinephrine   • response to metal ion   • response to calcium ion   • cellular response to endogenous stimulus   • cellular response to growth factor stimulus   • response to transforming growth factor beta   • cellular response to transforming growth factor beta stimulus   • response to endogenous stimulus   • response to growth factor   • behavior   • general adaptation syndrome   • response to stress   • general adaptation syndrome, behavioral process   • multicellular organismal response to stress   • G protein-coupled opioid receptor signaling pathway   • regulation of defense response   • regulation of fear response   • positive regulation of biological process   • regulation of behavioral fear response   • positive regulation of response to stimulus   • regulation of behavior   • behavioral defense response   • regulation of response to stress   • regulation of multicellular organismal process   • behavioral fear response   • defense response   • positive regulation of behavioral fear response   • fear response   • positive regulation of fear response   • positive regulation of behavior   • regulation of response to stimulus   • positive regulation of defense response   • positive regulation of multicellular organismal process   • response to toxic substance   • cellular response to nitrogen compound   • response to organophosphorus   • response to oxygen-containing compound   • response to nitrogen compound   • response to purine-containing compound   • response to cAMP   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to cAMP   • system process   • sensory perception   • nervous system process   • response to oxidative stress   • cellular response to stress   • cellular response to oxidative stress   • cellular response to chemical stress   • locomotory behavior   • exploration behavior   • locomotory exploration behavior   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • response to alcohol   • response to ethanol   • startle response   • neuromuscular process   • response to external stimulus   • synaptic signaling   • cell-cell signaling   • synaptic signaling via neuropeptide   • transmission of nerve impulse   • aggressive behavior   • response to immobilization stress   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • sensory perception of pain   • response to nicotine   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to lipopolysaccharide   • response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • response to estradiol   • cellular response to virus   • response to virus   • cell population proliferation   • nervous system development   • neurogenesis   • multicellular organism development   • gliogenesis   • anatomical structure development   • glial cell proliferation   • system development   • symmetric synapse   • neuron to neuron synapse   • intracellular anatomical structure   • intracellular vesicle   • membrane-enclosed lumen   • cytoplasmic vesicle lumen   • endomembrane system   • intracellular organelle lumen   • intracellular organelle   • cytoplasmic vesicle   • neuronal dense core vesicle lumen   • neuronal dense core vesicle   • vesicle lumen   • dense core granule   • intracellular membrane-bounded organelle   • secretory granule lumen   • organelle lumen   • secretory granule   • dense core granule lumen   • secretory vesicle   • cytoplasm   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • chromaffin granule lumen   • chromaffin granule   • cell body fiber   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • dendrite   • dendritic tree   • endoplasmic reticulum lumen   • endoplasmic reticulum   • axon   • axon terminus   • presynapse   • distal axon   • neuron projection terminus   • synaptic vesicle   • transport vesicle   • synaptic vesicle lumen   • exocytic vesicle   • D2 dopamine receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to prostaglandin E   • cellular response to forskolin   • cellular response to alcohol   • response to forskolin   • cellular response to ketone   • midbody   • nucleus   • intracellular membraneless organelle   • nucleolus   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • response to chloroquine   • cell surface receptor signaling pathway   • acute-phase response   • inflammatory response   • acute inflammatory response   • cell surface
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8JGG_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKSTIV 
KQMKITGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JGG_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JGG_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF REK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB2
Sequence
>8JGG_Chain_R
LSLTVLTCI VSLVGLTGN AVVLWLLGC RMRRNAFSI YILNLAAAD 
FLFLSGRLI YSLLKILYP VMMFSYFAG LSFLSAVST ERCLSVLWP 
IWYRCHRPT HLSAVVCVL LWALSLLRS ILEWMWCQT SDFITVAWL 
IFLCVVLCG SSLVLLIRI LCGSRTRLY VTILLTVLV FLLCGLPFG 
IQFFLFLWI HVDREVLFC HVHLVSIFL SALNSSANP IIYFFVG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JGFAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-1010.1038/s41467-023-40705-z
8JGF (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-2.72024-01-1010.1038/s41467-023-40705-z
8JGGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-Gi1/β1/γ232024-01-1010.1038/s41467-023-40705-z
8JGG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-32024-01-1010.1038/s41467-023-40705-z
8JGBAOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-Gi1/β1/γ22.842024-01-1010.1038/s41467-023-40705-z
8JGB (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-2.842024-01-1010.1038/s41467-023-40705-z
8HJ5AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ232023-05-3110.1371/journal.pbio.3001975
8HJ5 (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-32023-05-3110.1371/journal.pbio.3001975
8DWHAOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ23.252022-11-0210.1038/s41589-022-01173-6
8DWH (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-3.252022-11-0210.1038/s41589-022-01173-6
8DWGAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML382chim(NtGi2L-Gs-CtGq)/β1/γ22.712022-11-0210.1038/s41589-022-01173-6
8DWG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML3822.712022-11-0210.1038/s41589-022-01173-6
8DWCAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ22.872022-11-0210.1038/s41589-022-01173-6
8DWC (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-2.872022-11-0210.1038/s41589-022-01173-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JGG.zip



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