Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:W14 8.535610
2L:L:Y17 14.898510
3L:L:R20 7.24810
4L:L:Y21 9.745410
5R:R:V48 5.55429
6R:R:R58 4.2625427
7R:R:Y64 4.73167607
8R:R:F75 5.74506
9R:R:R79 7.155406
10R:R:Y99 9.17167613
11R:R:Y106 7.932517
12R:R:F107 4.62143716
13R:R:F112 6.89647
14R:R:L113 4.8438
15R:R:E119 7.7575459
16R:R:L125 5.155477
17R:R:Y130 8.78457
18R:R:R134 6.41167659
19R:R:W147 7.4275449
20R:R:E157 8.688514
21R:R:D177 7.19414
22R:R:I218 3.9875408
23R:R:F225 6.75408
24R:R:F232 6.7925415
25R:R:F236 5.9525414
26R:R:F237 6.73143715
27R:R:F239 8.8125414
28R:R:L240 5.778514
29R:R:W241 7.41413
30R:R:H243 8.8825411
31R:R:L249 4.735413
32R:R:V253 4.705414
33R:R:N264 5.5525439
34R:R:Y272 4.985639
35R:R:F273 9.1475427
36R:R:F274 4.2427
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:W14 R:R:L240 11.763310.25YesYes104
2L:L:Q18 L:L:Y17 11.64469.02NoYes100
3L:L:R20 R:R:L240 14.77734.86YesYes104
4R:R:D177 R:R:F237 22.917511.94YesYes145
5R:R:F107 R:R:F237 51.11943.22YesYes165
6R:R:F107 R:R:Y106 75.78515.16YesYes167
7R:R:F75 R:R:Y106 53.87236.19YesYes067
8R:R:F75 R:R:R79 44.80665.34YesYes066
9R:R:I258 R:R:R79 30.844112.53NoYes046
10R:R:I258 R:R:T34 28.69247.6NoNo045
11R:R:F75 R:R:S265 49.07056.61YesNo069
12R:R:D72 R:R:S265 48.055.89NoNo099
13R:R:D72 R:R:N45 41.91129.42NoNo099
14R:R:N45 R:R:P269 40.259.77NoNo099
15R:R:P269 R:R:V48 38.57291.77NoYes099
16R:R:F274 R:R:V48 18.66153.93YesYes279
17R:R:F274 R:R:V47 13.66193.93YesNo076
18R:R:G44 R:R:V47 12.1431.84NoNo086
19R:R:G44 R:R:T43 10.15743.64NoNo085
20R:R:F259 R:R:T34 18.48759.08NoNo055
21R:R:F259 R:R:V37 13.28229.18NoNo057
22R:R:L76 R:R:S265 15.44976.01NoNo079
23R:R:F273 R:R:V48 16.501913.11YesYes279
24R:R:F273 R:R:L52 11.85039.74YesNo277
25R:R:L110 R:R:Y106 76.188610.55NoYes077
26R:R:F225 R:R:L110 75.98296.09YesNo087
27R:R:F225 R:R:L113 79.6144.87YesYes088
28R:R:L113 R:R:Y272 99.87344.69YesYes389
29R:R:R120 R:R:Y272 1007.2NoYes099
30R:R:R120 R:R:V116 99.30393.92NoNo098
31R:R:V116 R:R:Y64 99.32762.52NoYes087
32R:R:E119 R:R:Y64 56.21397.86YesYes097
33R:R:E119 R:R:R134 13.28229.3YesYes599
34R:R:S139 R:R:Y64 14.8013.82NoYes097
35R:R:R134 R:R:S139 11.63673.95YesNo099
36R:R:V142 R:R:Y64 12.59398.83NoYes067
37R:R:C143 R:R:Y64 24.56292.69NoYes077
38R:R:C143 R:R:F112 15.13335.59NoYes477
39R:R:D72 R:R:L68 40.14712.71NoNo099
40R:R:L113 R:R:L68 40.32912.77YesNo089
41R:R:F232 R:R:Y106 22.245113.41YesYes157
42R:R:F107 R:R:L184 22.54576.09YesNo168
43R:R:L113 R:R:N268 15.04636.87YesNo389
44R:R:E119 R:R:L122 35.5512.65YesNo096
45R:R:L122 R:R:W126 33.85022.28NoNo066
46R:R:L125 R:R:W126 32.13355.69YesNo076
47R:R:E119 R:R:Y130 12.348711.22YesYes597
48R:R:L125 R:R:R201 23.97757.29YesNo076
49R:R:R201 R:R:V124 22.5222.62NoNo068
50R:R:L198 R:R:V124 20.68674.47NoNo088
51R:R:R134 R:R:W129 17.98913YesNo595
52R:R:H133 R:R:W129 21.69925.29NoNo055
53R:R:C132 R:R:H133 16.29624.42NoNo065
54R:R:I234 R:R:L184 10.35522.85NoNo168
55R:R:L184 R:R:L230 10.52922.77NoNo185
56R:R:I218 R:R:L198 18.82764.28YesNo088
57R:R:N264 R:R:N268 19.68999.54YesNo399
58R:R:G229 R:R:N264 12.00065.09NoYes089
59R:R:Q235 R:R:S257 25.96314.33NoNo036
60R:R:L249 R:R:V253 10.40274.47YesYes134
61R:R:G229 R:R:P231 10.03882.03NoNo089
62R:R:C132 R:R:I128 10.87731.64NoNo066
63R:R:D177 R:R:L240 13.36135.43YesYes144
64L:L:R20 R:R:F237 20.84496.41YesYes105
65R:R:F232 R:R:S257 27.53743.96YesNo056
66L:L:Q18 R:R:L240 13.79642.66NoYes104
67R:R:Q235 R:R:V253 27.42664.3NoYes034
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:P11 R:R:W241 6.76 1 No Yes 0 3 0 1
L:L:W14 R:R:L240 10.25 1 Yes Yes 0 4 0 1
L:L:W14 R:R:W241 9.37 1 Yes Yes 0 3 0 1
L:L:Y17 R:R:L249 7.03 1 Yes Yes 0 3 0 1
L:L:Y17 R:R:F250 27.85 1 Yes No 0 3 0 1
L:L:Y17 R:R:H254 17.42 1 Yes No 0 1 0 1
L:L:Q18 R:R:L240 2.66 1 No Yes 0 4 0 1
L:L:R20 R:R:Y99 19.55 1 Yes Yes 0 3 0 1
L:L:R20 R:R:E157 11.63 1 Yes Yes 0 4 0 1
L:L:R20 R:R:Q174 3.5 1 Yes No 0 3 0 1
L:L:R20 R:R:D177 3.57 1 Yes Yes 0 4 0 1
L:L:R20 R:R:F236 4.28 1 Yes Yes 0 4 0 1
L:L:R20 R:R:F237 6.41 1 Yes Yes 0 5 0 1
L:L:R20 R:R:L240 4.86 1 Yes Yes 0 4 0 1
L:L:Y21 R:R:Y99 5.96 1 Yes Yes 0 3 0 1
L:L:Y21 R:R:E157 13.47 1 Yes Yes 0 4 0 1
L:L:Y21 R:R:W158 15.43 1 Yes No 0 4 0 1
R:R:P100 R:R:Y99 5.56 0 No Yes 4 3 2 1
R:R:M103 R:R:Y99 11.97 1 No Yes 2 3 2 1
R:R:E157 R:R:Y99 7.86 1 Yes Yes 4 3 1 1
R:R:F236 R:R:Y99 4.13 1 Yes Yes 4 3 1 1
R:R:F107 R:R:M103 3.73 1 Yes No 6 2 2 2
R:R:F237 R:R:M103 4.98 1 Yes No 5 2 1 2
R:R:F107 R:R:R153 8.55 1 Yes No 6 4 2 2
R:R:F107 R:R:T180 2.59 1 Yes No 6 5 2 2
R:R:F107 R:R:F237 3.22 1 Yes Yes 6 5 2 1
R:R:E157 R:R:R153 5.82 1 Yes No 4 4 1 2
R:R:R153 R:R:T180 6.47 1 No No 4 5 2 2
R:R:E157 R:R:F237 4.66 1 Yes Yes 4 5 1 1
R:R:Q174 R:R:S176 2.89 0 No No 3 3 1 2
R:R:D177 R:R:F237 11.94 1 Yes Yes 4 5 1 1
R:R:D177 R:R:L240 5.43 1 Yes Yes 4 4 1 1
R:R:D177 R:R:W241 7.82 1 Yes Yes 4 3 1 1
R:R:F237 R:R:T180 5.19 1 Yes No 5 5 1 2
R:R:F236 R:R:Q235 4.68 1 Yes No 4 3 1 2
R:R:Q235 R:R:V253 4.3 0 No Yes 3 4 2 2
R:R:F236 R:R:F237 10.72 1 Yes Yes 4 5 1 1
R:R:F239 R:R:H243 22.63 1 Yes Yes 4 1 2 2
R:R:F239 R:R:L249 4.87 1 Yes Yes 4 3 2 1
R:R:F239 R:R:V253 5.24 1 Yes Yes 4 4 2 2
R:R:L240 R:R:W241 5.69 1 Yes Yes 4 3 1 1
R:R:H243 R:R:L249 2.57 1 Yes Yes 1 3 2 1
R:R:L249 R:R:V253 4.47 1 Yes Yes 3 4 1 2
R:R:F250 R:R:H254 13.58 1 No No 3 1 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JGG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.52
Number of Linked Nodes 208
Number of Links 248
Number of Hubs 36
Number of Links mediated by Hubs 131
Number of Communities 7
Number of Nodes involved in Communities 61
Number of Links involved in Communities 90
Path Summary
Number Of Nodes in MetaPath 68
Number Of Links MetaPath 67
Number of Shortest Paths 28386
Length Of Smallest Path 3
Average Path Length 13.0083
Length of Longest Path 30
Minimum Path Strength 1.38
Average Path Strength 5.72272
Maximum Path Strength 20.51
Minimum Path Correlation 0.7
Average Path Correlation 0.914308
Maximum Path Correlation 0.98
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 44.4094
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.2867
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • cell surface receptor signaling pathway   • response to stimulus   • signaling   • biological regulation   • cellular process   • signal transduction   • cell communication   • sneeze reflex   • reflex   • response to external stimulus   • acute-phase response   • defense response   • response to stress   • inflammatory response   • acute inflammatory response   • multicellular organismal process   • system process   • negative regulation of nervous system process   • nervous system process   • regulation of system process   • negative regulation of biological process   • sensory perception of pain   • regulation of nervous system process   • sensory perception   • regulation of sensory perception   • regulation of multicellular organismal process   • regulation of sensory perception of pain   • negative regulation of multicellular organismal process   • negative regulation of sensory perception of pain   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to chemical   • response to chloroquine   • response to nitrogen compound   • sensory perception of itch   • cell surface   • cellular anatomical structure   • cell periphery   • plasma membrane   • membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • opioid receptor binding   • molecular function activator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • hormone activity   • neuropeptide hormone activity   • neuropeptide activity   • opioid peptide activity   • response to metal ion   • response to calcium ion   • behavior   • general adaptation syndrome   • general adaptation syndrome, behavioral process   • multicellular organismal response to stress   • G protein-coupled opioid receptor signaling pathway   • response to toxic substance   • response to oxidative stress   • cellular response to stress   • cellular response to oxidative stress   • cellular response to chemical stress   • drinking behavior   • feeding behavior   • startle response   • neuromuscular process   • transmission of nerve impulse   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • cellular developmental process   • ossification   • cell differentiation   • osteoblast differentiation   • response to epinephrine   • cellular response to growth factor stimulus   • response to transforming growth factor beta   • cellular response to transforming growth factor beta stimulus   • response to growth factor   • regulation of defense response   • regulation of fear response   • regulation of behavioral fear response   • positive regulation of response to stimulus   • regulation of behavior   • behavioral defense response   • regulation of response to stress   • behavioral fear response   • positive regulation of behavioral fear response   • fear response   • positive regulation of fear response   • positive regulation of behavior   • regulation of response to stimulus   • positive regulation of defense response   • response to organophosphorus   • response to purine-containing compound   • response to cAMP   • cellular response to cAMP   • adult behavior   • behavioral response to ethanol   • response to ethanol   • locomotory behavior   • exploration behavior   • locomotory exploration behavior   • response to nutrient levels   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to nutrient   • synaptic signaling via neuropeptide   • aggressive behavior   • response to immobilization stress   • response to nicotine   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to lipopolysaccharide   • response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • response to estradiol   • cellular response to virus   • response to virus   • nervous system development   • neurogenesis   • gliogenesis   • glial cell proliferation   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • vesicle lumen   • chromaffin granule lumen   • intracellular vesicle   • cytoplasmic vesicle lumen   • secretory granule lumen   • chromaffin granule   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • dendrite   • dendritic tree   • endoplasmic reticulum lumen   • endoplasmic reticulum   • symmetric synapse   • neuron to neuron synapse   • neuronal dense core vesicle lumen   • neuronal dense core vesicle   • dense core granule   • dense core granule lumen   • cell body fiber   • axon   • axon terminus   • presynapse   • distal axon   • neuron projection terminus   • synaptic vesicle   • transport vesicle   • synaptic vesicle lumen   • exocytic vesicle   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinBAM8-22
UniProtP01210
Sequence
>8JGG_nogp_Chain_L
PEWWMDYQK RY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB2
Sequence
>8JGG_nogp_Chain_R
LSLTVLTCI VSLVGLTGN AVVLWLLGC RMRRNAFSI YILNLAAAD 
FLFLSGRLI YSLLKILYP VMMFSYFAG LSFLSAVST ERCLSVLWP 
IWYRCHRPT HLSAVVCVL LWALSLLRS ILEWMWCQT SDFITVAWL 
IFLCVVLCG SSLVLLIRI LCGSRTRLY VTILLTVLV FLLCGLPFG 
IQFFLFLWI HVDREVLFC HVHLVSIFL SALNSSANP IIYFFVG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8DWCAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ22.872022-11-02doi.org/10.1038/s41589-022-01173-6
8DWC (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-2.872022-11-02doi.org/10.1038/s41589-022-01173-6
8DWGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22ML382chim(NtGi2L-Gs-CtGq)/β1/γ22.712022-11-02doi.org/10.1038/s41589-022-01173-6
8DWG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22ML3822.712022-11-02doi.org/10.1038/s41589-022-01173-6
8DWHAOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ23.252022-11-02doi.org/10.1038/s41589-022-01173-6
8DWH (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-3.252022-11-02doi.org/10.1038/s41589-022-01173-6
8HJ5AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ232023-05-31doi.org/10.1371/journal.pbio.3001975
8HJ5 (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-32023-05-31doi.org/10.1371/journal.pbio.3001975
8JGBAOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-Gi1/β1/γ22.842024-01-10doi.org/10.1038/s41467-023-40705-z
8JGB (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-2.842024-01-10doi.org/10.1038/s41467-023-40705-z
8JGFAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-10doi.org/10.1038/s41467-023-40705-z
8JGF (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-2.72024-01-10doi.org/10.1038/s41467-023-40705-z
8JGGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-Gi1/β1/γ232024-01-10doi.org/10.1038/s41467-023-40705-z
8JGG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-32024-01-10doi.org/10.1038/s41467-023-40705-z




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