Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:W14 8.535610
2L:L:Y17 14.898510
3L:L:R20 7.24810
4L:L:Y21 9.745410
5R:R:V48 5.55429
6R:R:R58 4.2625427
7R:R:Y64 4.73167607
8R:R:F75 5.74506
9R:R:R79 7.155406
10R:R:Y99 9.17167613
11R:R:Y106 7.932517
12R:R:F107 4.62143716
13R:R:F112 6.89647
14R:R:L113 4.8438
15R:R:E119 7.7575459
16R:R:L125 5.155477
17R:R:Y130 8.78457
18R:R:R134 6.41167659
19R:R:W147 7.4275449
20R:R:E157 8.688514
21R:R:D177 7.19414
22R:R:I218 3.9875408
23R:R:F225 6.75408
24R:R:F232 6.7925415
25R:R:F236 5.9525414
26R:R:F237 6.73143715
27R:R:F239 8.8125414
28R:R:L240 5.778514
29R:R:W241 7.41413
30R:R:H243 8.8825411
31R:R:L249 4.735413
32R:R:V253 4.705414
33R:R:N264 5.5525439
34R:R:Y272 4.985639
35R:R:F273 9.1475427
36R:R:F274 4.2427
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:W14 R:R:L240 11.763310.25YesYes104
2L:L:Q18 L:L:Y17 11.64469.02NoYes100
3L:L:R20 R:R:L240 14.77734.86YesYes104
4R:R:D177 R:R:F237 22.917511.94YesYes145
5R:R:F107 R:R:F237 51.11943.22YesYes165
6R:R:F107 R:R:Y106 75.78515.16YesYes167
7R:R:F75 R:R:Y106 53.87236.19YesYes067
8R:R:F75 R:R:R79 44.80665.34YesYes066
9R:R:I258 R:R:R79 30.844112.53NoYes046
10R:R:I258 R:R:T34 28.69247.6NoNo045
11R:R:F75 R:R:S265 49.07056.61YesNo069
12R:R:D72 R:R:S265 48.055.89NoNo099
13R:R:D72 R:R:N45 41.91129.42NoNo099
14R:R:N45 R:R:P269 40.259.77NoNo099
15R:R:P269 R:R:V48 38.57291.77NoYes099
16R:R:F274 R:R:V48 18.66153.93YesYes279
17R:R:F274 R:R:V47 13.66193.93YesNo076
18R:R:G44 R:R:V47 12.1431.84NoNo086
19R:R:G44 R:R:T43 10.15743.64NoNo085
20R:R:F259 R:R:T34 18.48759.08NoNo055
21R:R:F259 R:R:V37 13.28229.18NoNo057
22R:R:L76 R:R:S265 15.44976.01NoNo079
23R:R:F273 R:R:V48 16.501913.11YesYes279
24R:R:F273 R:R:L52 11.85039.74YesNo277
25R:R:L110 R:R:Y106 76.188610.55NoYes077
26R:R:F225 R:R:L110 75.98296.09YesNo087
27R:R:F225 R:R:L113 79.6144.87YesYes088
28R:R:L113 R:R:Y272 99.87344.69YesYes389
29R:R:R120 R:R:Y272 1007.2NoYes099
30R:R:R120 R:R:V116 99.30393.92NoNo098
31R:R:V116 R:R:Y64 99.32762.52NoYes087
32R:R:E119 R:R:Y64 56.21397.86YesYes097
33R:R:E119 R:R:R134 13.28229.3YesYes599
34R:R:S139 R:R:Y64 14.8013.82NoYes097
35R:R:R134 R:R:S139 11.63673.95YesNo099
36R:R:V142 R:R:Y64 12.59398.83NoYes067
37R:R:C143 R:R:Y64 24.56292.69NoYes077
38R:R:C143 R:R:F112 15.13335.59NoYes477
39R:R:D72 R:R:L68 40.14712.71NoNo099
40R:R:L113 R:R:L68 40.32912.77YesNo089
41R:R:F232 R:R:Y106 22.245113.41YesYes157
42R:R:F107 R:R:L184 22.54576.09YesNo168
43R:R:L113 R:R:N268 15.04636.87YesNo389
44R:R:E119 R:R:L122 35.5512.65YesNo096
45R:R:L122 R:R:W126 33.85022.28NoNo066
46R:R:L125 R:R:W126 32.13355.69YesNo076
47R:R:E119 R:R:Y130 12.348711.22YesYes597
48R:R:L125 R:R:R201 23.97757.29YesNo076
49R:R:R201 R:R:V124 22.5222.62NoNo068
50R:R:L198 R:R:V124 20.68674.47NoNo088
51R:R:R134 R:R:W129 17.98913YesNo595
52R:R:H133 R:R:W129 21.69925.29NoNo055
53R:R:C132 R:R:H133 16.29624.42NoNo065
54R:R:I234 R:R:L184 10.35522.85NoNo168
55R:R:L184 R:R:L230 10.52922.77NoNo185
56R:R:I218 R:R:L198 18.82764.28YesNo088
57R:R:N264 R:R:N268 19.68999.54YesNo399
58R:R:G229 R:R:N264 12.00065.09NoYes089
59R:R:Q235 R:R:S257 25.96314.33NoNo036
60R:R:L249 R:R:V253 10.40274.47YesYes134
61R:R:G229 R:R:P231 10.03882.03NoNo089
62R:R:C132 R:R:I128 10.87731.64NoNo066
63R:R:D177 R:R:L240 13.36135.43YesYes144
64L:L:R20 R:R:F237 20.84496.41YesYes105
65R:R:F232 R:R:S257 27.53743.96YesNo056
66L:L:Q18 R:R:L240 13.79642.66NoYes104
67R:R:Q235 R:R:V253 27.42664.3NoYes034
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:P11 R:R:W241 6.76 1 No Yes 0 3 0 1
L:L:W14 R:R:L240 10.25 1 Yes Yes 0 4 0 1
L:L:W14 R:R:W241 9.37 1 Yes Yes 0 3 0 1
L:L:Y17 R:R:L249 7.03 1 Yes Yes 0 3 0 1
L:L:Y17 R:R:F250 27.85 1 Yes No 0 3 0 1
L:L:Y17 R:R:H254 17.42 1 Yes No 0 1 0 1
L:L:Q18 R:R:L240 2.66 1 No Yes 0 4 0 1
L:L:R20 R:R:Y99 19.55 1 Yes Yes 0 3 0 1
L:L:R20 R:R:E157 11.63 1 Yes Yes 0 4 0 1
L:L:R20 R:R:Q174 3.5 1 Yes No 0 3 0 1
L:L:R20 R:R:D177 3.57 1 Yes Yes 0 4 0 1
L:L:R20 R:R:F236 4.28 1 Yes Yes 0 4 0 1
L:L:R20 R:R:F237 6.41 1 Yes Yes 0 5 0 1
L:L:R20 R:R:L240 4.86 1 Yes Yes 0 4 0 1
L:L:Y21 R:R:Y99 5.96 1 Yes Yes 0 3 0 1
L:L:Y21 R:R:E157 13.47 1 Yes Yes 0 4 0 1
L:L:Y21 R:R:W158 15.43 1 Yes No 0 4 0 1
R:R:P100 R:R:Y99 5.56 0 No Yes 4 3 2 1
R:R:M103 R:R:Y99 11.97 1 No Yes 2 3 2 1
R:R:E157 R:R:Y99 7.86 1 Yes Yes 4 3 1 1
R:R:F236 R:R:Y99 4.13 1 Yes Yes 4 3 1 1
R:R:F107 R:R:M103 3.73 1 Yes No 6 2 2 2
R:R:F237 R:R:M103 4.98 1 Yes No 5 2 1 2
R:R:F107 R:R:R153 8.55 1 Yes No 6 4 2 2
R:R:F107 R:R:T180 2.59 1 Yes No 6 5 2 2
R:R:F107 R:R:F237 3.22 1 Yes Yes 6 5 2 1
R:R:E157 R:R:R153 5.82 1 Yes No 4 4 1 2
R:R:R153 R:R:T180 6.47 1 No No 4 5 2 2
R:R:E157 R:R:F237 4.66 1 Yes Yes 4 5 1 1
R:R:Q174 R:R:S176 2.89 0 No No 3 3 1 2
R:R:D177 R:R:F237 11.94 1 Yes Yes 4 5 1 1
R:R:D177 R:R:L240 5.43 1 Yes Yes 4 4 1 1
R:R:D177 R:R:W241 7.82 1 Yes Yes 4 3 1 1
R:R:F237 R:R:T180 5.19 1 Yes No 5 5 1 2
R:R:F236 R:R:Q235 4.68 1 Yes No 4 3 1 2
R:R:Q235 R:R:V253 4.3 0 No Yes 3 4 2 2
R:R:F236 R:R:F237 10.72 1 Yes Yes 4 5 1 1
R:R:F239 R:R:H243 22.63 1 Yes Yes 4 1 2 2
R:R:F239 R:R:L249 4.87 1 Yes Yes 4 3 2 1
R:R:F239 R:R:V253 5.24 1 Yes Yes 4 4 2 2
R:R:L240 R:R:W241 5.69 1 Yes Yes 4 3 1 1
R:R:H243 R:R:L249 2.57 1 Yes Yes 1 3 2 1
R:R:L249 R:R:V253 4.47 1 Yes Yes 3 4 1 2
R:R:F250 R:R:H254 13.58 1 No No 3 1 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JGG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.52
Number of Linked Nodes 208
Number of Links 248
Number of Hubs 36
Number of Links mediated by Hubs 131
Number of Communities 7
Number of Nodes involved in Communities 61
Number of Links involved in Communities 90
Path Summary
Number Of Nodes in MetaPath 68
Number Of Links MetaPath 67
Number of Shortest Paths 28386
Length Of Smallest Path 3
Average Path Length 13.0083
Length of Longest Path 30
Minimum Path Strength 1.38
Average Path Strength 5.72272
Maximum Path Strength 20.51
Minimum Path Correlation 0.7
Average Path Correlation 0.914308
Maximum Path Correlation 0.98
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 44.4094
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.2867
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • molecular transducer activity   • binding   • molecular function activator activity   • signaling receptor binding   • signaling receptor activity   • neuropeptide activity   • signaling receptor activator activity   • hormone activity   • protein binding   • molecular function regulator activity   • neuropeptide hormone activity   • signaling receptor regulator activity   • receptor ligand activity   • opioid peptide activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • developmental process   • multicellular organismal process   • cellular developmental process   • ossification   • cell differentiation   • osteoblast differentiation   • response to chemical   • response to epinephrine   • response to metal ion   • response to calcium ion   • cellular response to endogenous stimulus   • cellular response to growth factor stimulus   • response to transforming growth factor beta   • cellular response to transforming growth factor beta stimulus   • response to endogenous stimulus   • response to growth factor   • behavior   • general adaptation syndrome   • response to stress   • general adaptation syndrome, behavioral process   • multicellular organismal response to stress   • G protein-coupled opioid receptor signaling pathway   • regulation of defense response   • regulation of fear response   • positive regulation of biological process   • regulation of behavioral fear response   • positive regulation of response to stimulus   • regulation of behavior   • behavioral defense response   • regulation of response to stress   • regulation of multicellular organismal process   • behavioral fear response   • defense response   • positive regulation of behavioral fear response   • fear response   • positive regulation of fear response   • positive regulation of behavior   • regulation of response to stimulus   • positive regulation of defense response   • positive regulation of multicellular organismal process   • response to toxic substance   • cellular response to nitrogen compound   • response to organophosphorus   • response to oxygen-containing compound   • response to nitrogen compound   • response to purine-containing compound   • response to cAMP   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to cAMP   • system process   • sensory perception   • nervous system process   • response to oxidative stress   • cellular response to stress   • cellular response to oxidative stress   • cellular response to chemical stress   • locomotory behavior   • exploration behavior   • locomotory exploration behavior   • response to nutrient levels   • response to lipid   • response to nutrient   • response to vitamin   • cellular response to vitamin D   • cellular response to nutrient levels   • response to vitamin D   • cellular response to vitamin   • cellular response to lipid   • cellular response to nutrient   • response to alcohol   • response to ethanol   • startle response   • neuromuscular process   • response to external stimulus   • synaptic signaling   • cell-cell signaling   • synaptic signaling via neuropeptide   • transmission of nerve impulse   • aggressive behavior   • response to immobilization stress   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • sensory perception of pain   • response to nicotine   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to lipopolysaccharide   • response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • response to estradiol   • cellular response to virus   • response to virus   • cell population proliferation   • nervous system development   • neurogenesis   • multicellular organism development   • gliogenesis   • anatomical structure development   • glial cell proliferation   • system development   • symmetric synapse   • neuron to neuron synapse   • intracellular anatomical structure   • intracellular vesicle   • membrane-enclosed lumen   • cytoplasmic vesicle lumen   • endomembrane system   • intracellular organelle lumen   • intracellular organelle   • cytoplasmic vesicle   • neuronal dense core vesicle lumen   • neuronal dense core vesicle   • vesicle lumen   • dense core granule   • intracellular membrane-bounded organelle   • secretory granule lumen   • organelle lumen   • secretory granule   • dense core granule lumen   • secretory vesicle   • cytoplasm   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • chromaffin granule lumen   • chromaffin granule   • cell body fiber   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • dendrite   • dendritic tree   • endoplasmic reticulum lumen   • endoplasmic reticulum   • axon   • axon terminus   • presynapse   • distal axon   • neuron projection terminus   • synaptic vesicle   • transport vesicle   • synaptic vesicle lumen   • exocytic vesicle   • D2 dopamine receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to prostaglandin E   • cellular response to forskolin   • cellular response to alcohol   • response to forskolin   • cellular response to ketone   • midbody   • nucleus   • intracellular membraneless organelle   • nucleolus   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • response to chloroquine   • cell surface receptor signaling pathway   • acute-phase response   • inflammatory response   • acute inflammatory response   • cell surface
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ96LB2
Sequence
>8JGG_nogp_Chain_R
LSLTVLTCI VSLVGLTGN AVVLWLLGC RMRRNAFSI YILNLAAAD 
FLFLSGRLI YSLLKILYP VMMFSYFAG LSFLSAVST ERCLSVLWP 
IWYRCHRPT HLSAVVCVL LWALSLLRS ILEWMWCQT SDFITVAWL 
IFLCVVLCG SSLVLLIRI LCGSRTRLY VTILLTVLV FLLCGLPFG 
IQFFLFLWI HVDREVLFC HVHLVSIFL SALNSSANP IIYFFVG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JGFAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-1010.1038/s41467-023-40705-z
8JGF (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-2.72024-01-1010.1038/s41467-023-40705-z
8JGGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-Gi1/β1/γ232024-01-1010.1038/s41467-023-40705-z
8JGG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-32024-01-1010.1038/s41467-023-40705-z
8JGBAOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-Gi1/β1/γ22.842024-01-1010.1038/s41467-023-40705-z
8JGB (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-2.842024-01-1010.1038/s41467-023-40705-z
8HJ5AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ232023-05-3110.1371/journal.pbio.3001975
8HJ5 (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-32023-05-3110.1371/journal.pbio.3001975
8DWHAOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ23.252022-11-0210.1038/s41589-022-01173-6
8DWH (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-3.252022-11-0210.1038/s41589-022-01173-6
8DWGAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML382chim(NtGi2L-Gs-CtGq)/β1/γ22.712022-11-0210.1038/s41589-022-01173-6
8DWG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML3822.712022-11-0210.1038/s41589-022-01173-6
8DWCAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ22.872022-11-0210.1038/s41589-022-01173-6
8DWC (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-2.872022-11-0210.1038/s41589-022-01173-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JGG_nogp.zip



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