psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P11	L:L:W13	4.05	No	Yes	0	0	0
2	L:L:P11	R:R:S170	3.56	No	No	0	0	3
3	L:L:E12	L:L:W13	3.27	No	Yes	0	0	0
4	L:L:W13	L:L:W14	9.37	Yes	Yes	0	0	0
5	L:L:W13	R:R:H243	8.46	Yes	No	0	0	1
6	L:L:Q18	L:L:W14	14.24	No	Yes	1	0	0
7	L:L:W14	R:R:L240	11.39	Yes	Yes	1	0	4
8	L:L:W14	R:R:W241	8.43	Yes	Yes	1	0	3
9	L:L:M15	L:L:Y17	8.38	No	Yes	1	0	0
10	L:L:M15	R:R:R246	3.72	No	No	0	0	2
11	L:L:M15	R:R:F250	4.98	No	Yes	1	0	3
12	L:L:Q18	L:L:Y17	9.02	No	Yes	1	0	0
13	L:L:Y17	R:R:F250	6.19	Yes	Yes	1	0	3
14	L:L:Y17	R:R:H254	18.51	Yes	No	0	0	1
15	L:L:Q18	R:R:L240	5.32	No	Yes	1	0	4
16	L:L:R20	R:R:Y99	18.52	Yes	Yes	0	0	3
17	L:L:R20	R:R:E157	5.82	Yes	Yes	0	0	4
18	L:L:R20	R:R:C161	5.57	Yes	No	0	0	4
19	L:L:R20	R:R:D177	3.57	Yes	Yes	1	0	4
20	L:L:R20	R:R:L240	7.29	Yes	Yes	1	0	4
21	L:L:Y21	R:R:P100	8.34	No	No	0	0	4
22	L:L:Y21	R:R:W158	6.75	No	No	0	0	4
23	R:R:C23	R:R:C251	3.64	No	Yes	0	2	1
24	R:R:L28	R:R:Y24	4.69	No	No	0	4	3
25	R:R:H252	R:R:Q26	7.42	No	No	0	1	1
26	R:R:L30	R:R:S29	4.5	No	No	0	5	4
27	R:R:F259	R:R:L33	4.87	Yes	No	0	5	6
28	R:R:F259	R:R:T34	3.89	Yes	No	0	5	5
29	R:R:C35	R:R:S83	5.16	No	No	0	5	6
30	R:R:F259	R:R:V37	3.93	Yes	No	0	5	7
31	R:R:L80	R:R:S38	6.01	No	No	0	7	5
32	R:R:G41	R:R:S266	3.71	No	No	0	9	7
33	R:R:F73	R:R:L42	7.31	No	No	0	7	7
34	R:R:D72	R:R:N45	9.42	Yes	No	0	9	9
35	R:R:N45	R:R:P269	13.03	No	No	0	9	9
36	R:R:F274	R:R:V47	3.93	No	No	0	7	6
37	R:R:A69	R:R:V48	3.39	No	No	0	9	9
38	R:R:F73	R:R:L49	3.65	No	No	0	7	7
39	R:R:F273	R:R:L51	6.09	Yes	No	0	7	7
40	R:R:L52	R:R:L66	4.15	Yes	No	0	7	7
41	R:R:F273	R:R:L52	8.53	Yes	Yes	0	7	7
42	R:R:L66	R:R:R58	4.86	No	No	0	7	7
43	R:R:N59	R:R:S62	8.94	No	No	0	8	7
44	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
45	R:R:F61	R:R:I65	12.56	No	No	4	7	8
46	R:R:F61	R:R:V116	3.93	No	No	4	7	8
47	R:R:F61	R:R:Y272	5.16	No	Yes	4	7	9
48	R:R:I63	R:R:S139	6.19	No	Yes	0	7	9
49	R:R:A115	R:R:Y64	4	No	Yes	0	7	7
50	R:R:E119	R:R:Y64	13.47	Yes	Yes	3	9	7
51	R:R:S139	R:R:Y64	10.17	Yes	Yes	3	9	7
52	R:R:V142	R:R:Y64	5.05	No	Yes	0	6	7
53	R:R:C143	R:R:Y64	4.03	No	Yes	0	7	7
54	R:R:I65	R:R:Y272	4.84	No	Yes	4	8	9
55	R:R:F112	R:R:N67	4.83	Yes	No	2	7	9
56	R:R:C143	R:R:N67	11.02	No	No	0	7	9
57	R:R:N67	R:R:W147	5.65	No	Yes	2	9	9
58	R:R:D72	R:R:L68	5.43	Yes	No	2	9	9
59	R:R:F112	R:R:L68	4.87	Yes	No	2	7	9
60	R:R:L68	R:R:N268	5.49	No	No	2	9	9
61	R:R:D72	R:R:S265	11.78	Yes	No	0	9	9
62	R:R:D72	R:R:N268	6.73	Yes	No	2	9	9
63	R:R:L74	R:R:S105	7.51	No	No	0	7	8
64	R:R:F75	R:R:R79	8.55	Yes	No	0	6	6
65	R:R:F75	R:R:Y106	6.19	Yes	Yes	0	6	7
66	R:R:F75	R:R:S261	3.96	Yes	No	0	6	7
67	R:R:F75	R:R:S265	3.96	Yes	No	0	6	9
68	R:R:G78	R:R:L98	3.42	No	No	0	5	4
69	R:R:G78	R:R:M102	3.49	No	No	0	5	4
70	R:R:M102	R:R:R79	6.2	No	No	0	4	6
71	R:R:I258	R:R:R79	12.53	No	No	0	4	6
72	R:R:I81	R:R:L98	12.85	No	No	0	5	4
73	R:R:S95	R:R:Y82	7.63	No	No	0	7	3
74	R:R:L98	R:R:Y82	4.69	No	No	0	4	3
75	R:R:I90	R:R:L85	14.27	No	No	0	5	4
76	R:R:I90	R:R:P91	10.16	No	No	0	5	7
77	R:R:P100	R:R:Y99	8.34	No	Yes	0	4	3
78	R:R:M103	R:R:Y99	10.78	No	Yes	0	2	3
79	R:R:F236	R:R:Y99	7.22	No	Yes	0	4	3
80	R:R:F104	R:R:W147	7.02	Yes	Yes	0	5	9
81	R:R:F104	R:R:S150	7.93	Yes	No	0	5	8
82	R:R:F104	R:R:L151	7.31	Yes	No	0	5	4
83	R:R:F104	R:R:S154	3.96	Yes	No	0	5	6
84	R:R:F107	R:R:Y106	7.22	Yes	Yes	0	6	7
85	R:R:L110	R:R:Y106	10.55	No	Yes	0	7	7
86	R:R:F232	R:R:Y106	4.13	Yes	Yes	0	5	7
87	R:R:F107	R:R:R153	9.62	Yes	Yes	6	6	4
88	R:R:F107	R:R:T180	3.89	Yes	No	6	6	5
89	R:R:F107	R:R:L184	8.53	Yes	No	0	6	8
90	R:R:A108	R:R:W147	5.19	No	Yes	0	7	9
91	R:R:A108	R:R:S150	3.42	No	No	0	7	8
92	R:R:F225	R:R:L110	6.09	Yes	No	0	8	7
93	R:R:L146	R:R:S111	10.51	No	No	0	7	6
94	R:R:F112	R:R:L146	7.31	Yes	No	0	7	7
95	R:R:F112	R:R:W147	11.02	Yes	Yes	2	7	9
96	R:R:F225	R:R:L113	4.87	Yes	No	0	8	8
97	R:R:L113	R:R:Y272	5.86	No	Yes	0	8	9
98	R:R:L187	R:R:S114	6.01	No	No	0	9	8
99	R:R:V116	R:R:Y272	3.79	No	Yes	4	8	9
100	R:R:R120	R:R:S117	9.22	Yes	No	7	9	9
101	R:R:L191	R:R:S117	4.5	No	No	0	8	9
102	R:R:S117	R:R:S195	3.26	No	No	7	9	8
103	R:R:S194	R:R:T118	4.8	No	No	0	8	7
104	R:R:E119	R:R:Y130	4.49	Yes	No	3	9	7
105	R:R:E119	R:R:R134	11.63	Yes	Yes	3	9	9
106	R:R:E119	R:R:S139	4.31	Yes	Yes	3	9	9
107	R:R:R120	R:R:S195	3.95	Yes	No	7	9	8
108	R:R:L198	R:R:R120	4.86	Yes	Yes	0	8	9
109	R:R:R120	R:R:T221	6.47	Yes	No	0	9	8
110	R:R:C121	R:R:V197	3.42	No	No	0	8	4
111	R:R:L122	R:R:W129	3.42	No	No	0	6	5
112	R:R:S123	R:R:Y130	12.72	No	No	0	8	7
113	R:R:L198	R:R:V124	5.96	Yes	No	0	8	8
114	R:R:L125	R:R:W126	11.39	No	No	0	7	6
115	R:R:L125	R:R:V197	4.47	No	No	0	7	4
116	R:R:L125	R:R:R201	4.86	No	No	0	7	6
117	R:R:H133	R:R:W129	4.23	No	No	0	5	5
118	R:R:R134	R:R:W129	6	Yes	No	0	9	5
119	R:R:R134	R:R:Y130	9.26	Yes	No	3	9	7
120	R:R:C132	R:R:H133	4.42	No	No	0	6	5
121	R:R:L138	R:R:R134	10.93	No	Yes	0	4	9
122	R:R:R134	R:R:S139	5.27	Yes	Yes	3	9	9
123	R:R:L138	R:R:P135	3.28	No	No	0	4	7
124	R:R:H137	R:R:T136	10.95	No	No	0	6	4
125	R:R:I155	R:R:L151	4.28	No	No	0	4	4
126	R:R:R153	R:R:S154	3.95	Yes	No	0	4	6
127	R:R:E157	R:R:R153	8.14	Yes	Yes	0	4	4
128	R:R:R153	R:R:T180	7.76	Yes	No	6	4	5
129	R:R:L156	R:R:L160	6.92	No	Yes	0	7	3
130	R:R:E157	R:R:F237	4.66	Yes	Yes	0	4	5
131	R:R:F165	R:R:L160	6.09	No	Yes	8	1	3
132	R:R:L160	R:R:W172	6.83	Yes	No	8	3	1
133	R:R:C161	R:R:C173	7.28	No	No	0	4	9
134	R:R:A168	R:R:F165	4.16	No	No	0	2	1
135	R:R:F165	R:R:W172	15.03	No	No	8	1	1
136	R:R:C173	R:R:W241	6.53	No	Yes	0	9	3
137	R:R:Q174	R:R:W241	12.05	No	Yes	0	3	3
138	R:R:D177	R:R:F237	5.97	Yes	Yes	0	4	5
139	R:R:D177	R:R:L240	5.43	Yes	Yes	1	4	4
140	R:R:D177	R:R:W241	13.4	Yes	Yes	1	4	3
141	R:R:F237	R:R:T180	11.67	Yes	No	0	5	5
142	R:R:L187	R:R:W183	5.69	No	No	0	9	6
143	R:R:I234	R:R:L184	7.14	No	No	0	6	8
144	R:R:F186	R:R:V190	7.87	No	No	0	5	6
145	R:R:F225	R:R:L191	8.53	Yes	No	0	8	8
146	R:R:C192	R:R:L226	4.76	No	No	0	5	6
147	R:R:L198	R:R:L214	4.15	Yes	No	0	8	7
148	R:R:I218	R:R:L198	5.71	No	Yes	0	8	8
149	R:R:I218	R:R:L199	7.14	No	No	0	8	5
150	R:R:I202	R:R:L214	9.99	No	No	0	6	7
151	R:R:L203	R:R:Y215	5.86	No	No	0	5	6
152	R:R:I271	R:R:L220	5.71	Yes	No	0	8	6
153	R:R:T221	R:R:Y272	7.49	No	Yes	0	8	9
154	R:R:I271	R:R:V224	4.61	Yes	No	0	8	7
155	R:R:F225	R:R:L230	6.09	Yes	No	0	8	5
156	R:R:G229	R:R:N264	5.09	No	No	0	8	9
157	R:R:F232	R:R:Q235	5.86	Yes	Yes	5	5	3
158	R:R:F232	R:R:F236	5.36	Yes	No	5	5	4
159	R:R:F232	R:R:S257	5.28	Yes	No	5	5	6
160	R:R:F232	R:R:S261	7.93	Yes	No	0	5	7
161	R:R:F236	R:R:Q235	3.51	No	Yes	5	4	3
162	R:R:F239	R:R:Q235	3.51	No	Yes	0	4	3
163	R:R:Q235	R:R:V253	5.73	Yes	No	0	3	4
164	R:R:H254	R:R:Q235	3.71	No	Yes	0	1	3
165	R:R:Q235	R:R:S257	8.66	Yes	No	5	3	6
166	R:R:F239	R:R:L249	10.96	No	No	0	4	3
167	R:R:L240	R:R:W241	3.42	Yes	Yes	1	4	3
168	R:R:D245	R:R:E247	9.09	No	No	0	3	2
169	R:R:D245	R:R:V248	7.3	No	No	0	3	1
170	R:R:C251	R:R:F250	4.19	Yes	Yes	0	1	3
171	R:R:F250	R:R:L255	7.31	Yes	No	0	3	2
172	R:R:C251	R:R:H252	7.37	Yes	No	0	1	1
173	R:R:H254	R:R:I258	5.3	No	No	0	1	4
174	R:R:N264	R:R:N268	8.17	No	No	0	9	9
175	R:R:A267	R:R:I271	3.25	No	Yes	0	7	8
176	R:R:I271	R:R:Y272	3.63	Yes	Yes	0	8	9
177	R:R:F273	R:R:F274	5.36	Yes	No	0	7	7
178	R:R:F274	R:R:S277	6.61	No	No	0	7	6
179	R:R:S266	R:R:V37	3.23	No	No	0	7	7
180	R:R:S114	R:R:V190	3.23	No	No	0	8	6
181	R:R:S195	R:R:V222	3.23	No	No	0	8	8
182	R:R:F273	R:R:R55	3.21	Yes	No	0	7	6
183	R:R:C188	R:R:L230	3.17	No	No	0	6	5
184	R:R:A69	R:R:L49	3.15	No	No	0	9	7
185	R:R:A171	R:R:D169	3.09	No	No	0	4	3
186	R:R:I258	R:R:T34	3.04	No	No	0	4	5
187	R:R:F107	R:R:W183	3.01	Yes	No	0	6	6
188	R:R:F112	R:R:G109	3.01	Yes	No	0	7	9
189	R:R:F163	R:R:W158	3.01	No	No	0	4	4
190	R:R:F232	R:R:G233	3.01	Yes	No	0	5	7
191	R:R:F237	R:R:G233	3.01	Yes	No	0	5	7
192	R:R:L76	R:R:S38	3	No	No	0	7	5
193	R:R:L42	R:R:S77	3	No	No	0	7	5
194	R:R:L52	R:R:S62	3	Yes	No	0	7	7
195	R:R:L76	R:R:S265	3	No	No	0	7	9
196	R:R:L28	R:R:V32	2.98	No	No	0	4	6
197	R:R:L52	R:R:V48	2.98	Yes	No	0	7	9
198	R:R:L238	R:R:V181	2.98	No	No	0	5	5
199	R:R:L226	R:R:V222	2.98	No	No	0	6	8
200	R:R:L249	R:R:V244	2.98	No	No	0	3	1
201	R:R:L260	R:R:V256	2.98	No	No	0	7	4
202	R:R:I90	R:R:I94	2.94	No	No	0	5	5
203	R:R:D169	R:R:S170	2.94	No	No	0	3	3
204	R:R:I155	R:R:M159	2.92	No	No	0	4	4
205	R:R:E157	R:R:S176	2.87	Yes	No	0	4	3
206	R:R:I65	R:R:L52	2.85	No	Yes	0	8	7
207	R:R:I81	R:R:L85	2.85	No	No	0	5	4
208	R:R:I202	R:R:L211	2.85	No	No	0	6	6
209	R:R:I218	R:R:L219	2.85	No	No	0	8	5
210	R:R:L39	R:R:L80	2.77	No	No	0	5	7
211	R:R:A71	R:R:F112	2.77	No	Yes	0	9	7
212	R:R:L80	R:R:L84	2.77	No	No	0	7	5
213	R:R:H133	R:R:I128	2.65	No	No	0	5	6
214	R:R:R201	R:R:V124	2.62	No	No	0	6	8
215	R:R:F259	R:R:L260	2.44	Yes	No	0	5	7
216	R:R:L199	R:R:Y215	2.34	No	No	0	5	6
217	R:R:L214	R:R:Y215	2.34	No	No	0	7	6
218	R:R:L164	R:R:W158	2.28	No	No	0	1	4
219	R:R:G41	R:R:G44	2.11	No	No	0	9	8
220	R:R:G229	R:R:P231	2.03	No	No	0	8	9
221	R:R:G167	R:R:S166	1.86	No	No	0	1	1
222	R:R:G41	R:R:V40	1.84	No	No	0	9	6
223	R:R:G44	R:R:T43	1.82	No	No	0	8	5
224	R:R:P91	R:R:T93	1.75	No	No	0	7	2
225	R:R:C121	R:R:S194	1.72	No	No	0	8	8
226	R:R:A262	R:R:S38	1.71	No	No	0	6	5
227	R:R:C228	R:R:V224	1.71	No	No	0	8	7
228	R:R:C251	R:R:T27	1.69	Yes	No	0	1	4
229	R:R:S83	R:R:T31	1.6	No	No	0	6	4
230	R:R:V248	R:R:V253	1.6	No	No	0	1	4
231	R:R:C35	R:R:L84	1.59	No	No	0	5	5
232	R:R:T212	R:R:V216	1.59	No	No	0	5	7
233	R:R:C228	R:R:L227	1.59	No	No	0	8	5
234	R:R:C228	R:R:L263	1.59	No	No	0	8	5
235	R:R:A70	R:R:L49	1.58	No	No	0	6	7
236	R:R:T217	R:R:T221	1.57	No	No	0	7	8
237	R:R:I185	R:R:V181	1.54	No	No	0	5	5
238	R:R:I234	R:R:V181	1.54	No	No	0	6	5
239	R:R:I185	R:R:V189	1.54	No	No	0	5	4
240	R:R:I179	R:R:T175	1.52	No	No	0	5	4
241	R:R:G53	R:R:R58	1.5	No	No	0	5	7
242	R:R:L160	R:R:S176	1.5	Yes	No	0	3	3
243	R:R:L30	R:R:V256	1.49	No	No	0	5	4
244	R:R:L74	R:R:V101	1.49	No	No	0	7	6
245	R:R:L145	R:R:V141	1.49	No	No	0	4	5
246	R:R:I94	R:R:I97	1.47	No	No	0	5	4
247	L:L:Y21	R:R:G162	1.45	No	No	0	0	2
248	R:R:I97	R:R:K96	1.45	No	No	0	4	5
249	R:R:I36	R:R:L39	1.43	No	No	0	5	5
250	R:R:I88	R:R:L85	1.43	No	No	0	3	4
251	R:R:I179	R:R:L156	1.43	No	No	0	5	7
252	R:R:A46	R:R:F73	1.39	No	No	0	6	7
253	R:R:C132	R:R:R131	1.39	No	No	0	6	6
254	R:R:L145	R:R:L149	1.38	No	No	0	4	6
255	R:R:L223	R:R:L227	1.38	No	No	0	6	5
256	R:R:P127	R:R:W126	1.35	No	No	0	9	6
257	R:R:F75	R:R:S105	1.32	Yes	No	0	6	8
258	R:R:F104	R:R:S105	1.32	Yes	No	0	5	8
259	R:R:F278	R:R:S277	1.32	No	No	0	5	6
260	R:R:R213	R:R:V275	1.31	No	No	0	7	8
261	R:R:R213	R:R:T217	1.29	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W13	6.2875	4	0	0
2	L:L:W14	10.8575	4	1	0
3	L:L:Y17	10.525	4	1	0
4	L:L:R20	8.154	5	1	0
5	R:R:L52	4.302	5	0	7
6	R:R:Y64	7.344	5	3	7
7	R:R:D72	8.34	4	2	9
8	R:R:F75	4.796	5	0	6
9	R:R:Y99	11.215	4	0	3
10	R:R:F104	5.508	5	0	5
11	R:R:Y106	7.0225	4	0	7
12	R:R:F107	6.454	5	6	6
13	R:R:F112	5.635	6	2	7
14	R:R:E119	8.475	4	3	9
15	R:R:R120	6.125	4	7	9
16	R:R:R134	7.87333	6	3	9
17	R:R:S139	6.485	4	3	9
18	R:R:W147	7.22	4	2	9
19	R:R:R153	7.3675	4	6	4
20	R:R:E157	5.3725	4	0	4
21	R:R:L160	5.335	4	8	3
22	R:R:D177	7.0925	4	1	4
23	R:R:L198	5.17	4	0	8
24	R:R:F225	6.395	4	0	8
25	R:R:F232	5.26167	6	5	5
26	R:R:Q235	5.16333	6	5	3
27	R:R:F237	6.3275	4	0	5
28	R:R:L240	6.57	5	1	4
29	R:R:W241	8.766	5	1	3
30	R:R:F250	5.6675	4	1	3
31	R:R:C251	4.2225	4	0	1
32	R:R:F259	3.7825	4	0	5
33	R:R:I271	4.3	4	0	8
34	R:R:Y272	5.12833	6	4	9
35	R:R:F273	5.7975	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P11	L:L:W13	16.9452	4.05	No	Yes	0	0	0
2	L:L:W13	L:L:W14	30.0039	9.37	Yes	Yes	0	0	0
3	L:L:W14	R:R:L240	19.0051	11.39	Yes	Yes	1	0	4
4	L:L:Q18	L:L:Y17	12.8449	9.02	No	Yes	1	0	0
5	L:L:Y17	R:R:F250	10.1632	6.19	Yes	Yes	1	0	3
6	L:L:Y17	R:R:H254	23.0276	18.51	Yes	No	0	0	1
7	L:L:R20	R:R:L240	16.5889	7.29	Yes	Yes	1	0	4
8	L:L:R20	R:R:Y99	13.5704	18.52	Yes	Yes	0	0	3
9	L:L:R20	R:R:E157	19.7111	5.82	Yes	Yes	0	0	4
10	R:R:D177	R:R:W241	14.3348	13.4	Yes	Yes	1	4	3
11	R:R:P100	R:R:Y99	11.517	8.34	No	Yes	0	4	3
12	R:R:H254	R:R:I258	17.9622	5.3	No	No	0	1	4
13	R:R:I258	R:R:T34	21.8876	3.04	No	No	0	4	5
14	R:R:F259	R:R:T34	20.2811	3.89	Yes	No	0	5	5
15	R:R:I258	R:R:R79	27.0631	12.53	No	No	0	4	6
16	R:R:F75	R:R:R79	40.2772	8.55	Yes	No	0	6	6
17	R:R:F75	R:R:S265	31.4872	3.96	Yes	No	0	6	9
18	R:R:L76	R:R:S265	17.5476	3	No	No	0	7	9
19	R:R:L76	R:R:S38	15.8505	3	No	No	0	7	5
20	R:R:L80	R:R:S38	12.4174	6.01	No	No	0	7	5
21	R:R:F259	R:R:V37	10.3705	3.93	Yes	No	0	5	7
22	R:R:H254	R:R:Q235	17.3339	3.71	No	Yes	0	1	3
23	R:R:F232	R:R:Q235	23.3839	5.86	Yes	Yes	5	5	3
24	R:R:F232	R:R:Y106	44.2868	4.13	Yes	Yes	0	5	7
25	R:R:L110	R:R:Y106	100	10.55	No	Yes	0	7	7
26	R:R:F225	R:R:L110	98.9053	6.09	Yes	No	0	8	7
27	R:R:F225	R:R:L113	57.8767	4.87	Yes	No	0	8	8
28	R:R:L113	R:R:Y272	56.5941	5.86	No	Yes	0	8	9
29	R:R:I65	R:R:Y272	39.2149	4.84	No	Yes	4	8	9
30	R:R:I65	R:R:L52	38.036	2.85	No	Yes	0	8	7
31	R:R:L52	R:R:V48	15.2805	2.98	Yes	No	0	7	9
32	R:R:A69	R:R:V48	13.415	3.39	No	No	0	9	9
33	R:R:A69	R:R:L49	11.5365	3.15	No	No	0	9	7
34	R:R:F236	R:R:Y99	19.2188	7.22	No	Yes	0	4	3
35	R:R:F232	R:R:F236	16.2197	5.36	Yes	No	5	5	4
36	R:R:D177	R:R:F237	25.4048	5.97	Yes	Yes	0	4	5
37	R:R:F237	R:R:G233	14.6975	3.01	Yes	No	0	5	7
38	R:R:F232	R:R:G233	15.7209	3.01	Yes	No	0	5	7
39	R:R:E157	R:R:R153	27.4647	8.14	Yes	Yes	0	4	4
40	R:R:F107	R:R:R153	19.7111	9.62	Yes	Yes	6	6	4
41	R:R:F107	R:R:Y106	37.0968	7.22	Yes	Yes	0	6	7
42	R:R:F237	R:R:T180	14.4254	11.67	Yes	No	0	5	5
43	R:R:F107	R:R:T180	13.2401	3.89	Yes	No	6	6	5
44	R:R:D72	R:R:S265	18.6617	11.78	Yes	No	0	9	9
45	R:R:F273	R:R:L52	13.389	8.53	Yes	Yes	0	7	7
46	R:R:R153	R:R:S154	18.2407	3.95	Yes	No	0	4	6
47	R:R:F104	R:R:S154	17.9168	3.96	Yes	No	0	5	6
48	R:R:F104	R:R:W147	48.3353	7.02	Yes	Yes	0	5	9
49	R:R:N67	R:R:W147	38.6967	5.65	No	Yes	2	9	9
50	R:R:C143	R:R:N67	42.065	11.02	No	No	0	7	9
51	R:R:C143	R:R:Y64	40.7566	4.03	No	Yes	0	7	7
52	R:R:E119	R:R:Y64	18.8107	13.47	Yes	Yes	3	9	7
53	R:R:E119	R:R:R134	14.6586	11.63	Yes	Yes	3	9	9
54	R:R:S139	R:R:Y64	17.8002	10.17	Yes	Yes	3	9	7
55	R:R:R134	R:R:S139	14.9177	5.27	Yes	Yes	3	9	9
56	R:R:F75	R:R:S105	41.5468	1.32	Yes	No	0	6	8
57	R:R:F104	R:R:S105	39.1761	1.32	Yes	No	0	5	8
58	R:R:F232	R:R:S261	10.6296	7.93	Yes	No	0	5	7
59	R:R:M102	R:R:R79	23.481	6.2	No	No	0	4	6
60	R:R:G78	R:R:M102	21.8487	3.49	No	No	0	5	4
61	R:R:G78	R:R:L98	20.1904	3.42	No	No	0	5	4
62	R:R:I81	R:R:L98	15.4035	12.85	No	No	0	5	4
63	R:R:I81	R:R:L85	13.7194	2.85	No	No	0	5	4
64	R:R:I90	R:R:L85	10.2863	14.27	No	No	0	5	4
65	R:R:F107	R:R:L184	10.0596	8.53	Yes	No	0	6	8
66	R:R:F225	R:R:L191	38.1332	8.53	Yes	No	0	8	8
67	R:R:L191	R:R:S117	36.5462	4.5	No	No	0	8	9
68	R:R:R120	R:R:S117	29.0387	9.22	Yes	No	7	9	9
69	R:R:L198	R:R:R120	32.2645	4.86	Yes	Yes	0	8	9
70	R:R:L198	R:R:V124	17.0488	5.96	Yes	No	0	8	8
71	R:R:R201	R:R:V124	15.2157	2.62	No	No	0	6	8
72	R:R:L125	R:R:R201	13.3567	4.86	No	No	0	7	6
73	R:R:T221	R:R:Y272	11.8215	7.49	No	Yes	0	8	9
74	R:R:R134	R:R:W129	18.5322	6	Yes	No	0	9	5
75	R:R:H133	R:R:W129	12.4045	4.23	No	No	0	5	5
76	R:R:E157	R:R:S176	15.0214	2.87	Yes	No	0	4	3
77	R:R:L160	R:R:S176	13.1882	1.5	Yes	No	0	3	3
78	R:R:I271	R:R:Y272	14.9436	3.63	Yes	Yes	0	8	9
79	L:L:P11	R:R:S170	12.5664	3.56	No	No	0	0	3
80	R:R:F75	R:R:Y106	62.8255	6.19	Yes	Yes	0	6	7
81	R:R:F75	R:R:S261	10.7397	3.96	Yes	No	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P11	R:R:S170	3.56	0	No	No	0	3	0	1
L:L:W13	R:R:H243	8.46	0	Yes	No	0	1	0	1
L:L:W14	R:R:L240	11.39	1	Yes	Yes	0	4	0	1
L:L:W14	R:R:W241	8.43	1	Yes	Yes	0	3	0	1
L:L:M15	R:R:R246	3.72	1	No	No	0	2	0	1
L:L:M15	R:R:F250	4.98	1	No	Yes	0	3	0	1
L:L:Y17	R:R:F250	6.19	1	Yes	Yes	0	3	0	1
L:L:Y17	R:R:H254	18.51	1	Yes	No	0	1	0	1
L:L:Q18	R:R:L240	5.32	1	No	Yes	0	4	0	1
L:L:R20	R:R:Y99	18.52	1	Yes	Yes	0	3	0	1
L:L:R20	R:R:E157	5.82	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:C161	5.57	1	Yes	No	0	4	0	1
L:L:R20	R:R:D177	3.57	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:L240	7.29	1	Yes	Yes	0	4	0	1
L:L:Y21	R:R:P100	8.34	0	No	No	0	4	0	1
L:L:Y21	R:R:W158	6.75	0	No	No	0	4	0	1
R:R:P100	R:R:Y99	8.34	0	No	Yes	4	3	1	1
R:R:M103	R:R:Y99	10.78	0	No	Yes	2	3	2	1
R:R:F236	R:R:Y99	7.22	5	No	Yes	4	3	2	1
R:R:E157	R:R:R153	8.14	0	Yes	Yes	4	4	1	2
R:R:E157	R:R:F237	4.66	0	Yes	Yes	4	5	1	2
R:R:C161	R:R:C173	7.28	0	No	No	4	9	1	2
R:R:C173	R:R:W241	6.53	0	No	Yes	9	3	2	1
R:R:Q174	R:R:W241	12.05	0	No	Yes	3	3	2	1
R:R:D177	R:R:F237	5.97	1	Yes	Yes	4	5	1	2
R:R:D177	R:R:L240	5.43	1	Yes	Yes	4	4	1	1
R:R:D177	R:R:W241	13.4	1	Yes	Yes	4	3	1	1
R:R:F236	R:R:Q235	3.51	5	No	Yes	4	3	2	2
R:R:H254	R:R:Q235	3.71	0	No	Yes	1	3	1	2
R:R:L240	R:R:W241	3.42	1	Yes	Yes	4	3	1	1
R:R:C251	R:R:F250	4.19	0	Yes	Yes	1	3	2	1
R:R:F250	R:R:L255	7.31	1	Yes	No	3	2	1	2
R:R:H254	R:R:I258	5.3	0	No	No	1	4	1	2
R:R:F163	R:R:W158	3.01	0	No	No	4	4	2	1
R:R:D169	R:R:S170	2.94	0	No	No	3	3	2	1
R:R:E157	R:R:S176	2.87	0	Yes	No	4	3	1	2
R:R:L164	R:R:W158	2.28	0	No	No	1	4	2	1
L:L:Y21	R:R:G162	1.45	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DWC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.25
Number of Linked Nodes	237
Number of Links	261
Number of Hubs	35
Number of Links mediated by Hubs	128
Number of Communities	8
Number of Nodes involved in Communities	37
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	35308
Length Of Smallest Path	3
Average Path Length	12.4251
Length of Longest Path	27
Minimum Path Strength	1.3
Average Path Strength	6.13557
Maximum Path Strength	13.9233
Minimum Path Correlation	0.7
Average Path Correlation	0.917982
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	47.1313
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.659
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • startle response • multicellular organismal process • system process • nervous system process • neuromuscular process • response to external stimulus • behavior • locomotory behavior • transmission of nerve impulse • aggressive behavior • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • G protein-coupled opioid receptor signaling pathway • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • sensory perception • sensory perception of pain • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • cellular anatomical structure • extracellular region • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • chromaffin granule lumen • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • chromaffin granule • intracellular organelle lumen
Gene Ontology	Cellular Component	• cellular anatomical structure • extracellular region • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • chromaffin granule lumen • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • chromaffin granule • intracellular organelle lumen • intracellular organelle • cytoplasmic vesicle • organelle lumen • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • somatodendritic compartment • cell body • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse • distal axon • cell junction • neuron projection terminus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • response to chloroquine • cell surface receptor signaling pathway • acute-phase response • defense response • response to stress • inflammatory response • acute inflammatory response • cell surface
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8DWC_nogp_Chain_R C Y K Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I S I P H T I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G F L F S G A D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JGF	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGF (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/β1/γ2	3	2024-01-10	10.1038/s41467-023-40705-z
	8JGG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		3	2024-01-10	10.1038/s41467-023-40705-z
	8JGB	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/β1/γ2	2.84	2024-01-10	10.1038/s41467-023-40705-z
	8JGB (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-		2.84	2024-01-10	10.1038/s41467-023-40705-z
	8HJ5	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-05-31	10.1371/journal.pbio.3001975
	8HJ5 (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3	2023-05-31	10.1371/journal.pbio.3001975
	8DWH	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWH (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382		2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWC	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2022-11-02	10.1038/s41589-022-01173-6
	8DWC (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-		2.87	2022-11-02	10.1038/s41589-022-01173-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8DWC_nogp.zip

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