psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P11	L:L:W13	13.51	No	Yes	1	0	0
2	L:L:P11	L:L:W14	22.97	No	Yes	1	0	0
3	L:L:W13	L:L:W14	7.5	Yes	Yes	1	0	0
4	L:L:W13	R:R:H243	45.49	Yes	No	0	0	1
5	L:L:W14	R:R:L240	17.08	Yes	Yes	1	0	4
6	L:L:W14	R:R:W241	6.56	Yes	Yes	1	0	3
7	L:L:M15	L:L:Y17	7.18	No	Yes	0	0	0
8	L:L:M15	R:R:R246	17.37	No	No	0	0	2
9	L:L:Q18	L:L:Y17	19.16	No	Yes	0	0	0
10	L:L:Y17	R:R:L249	4.69	Yes	Yes	0	0	3
11	L:L:Y17	R:R:F250	7.22	Yes	No	0	0	3
12	L:L:Y17	R:R:H254	30.49	Yes	No	0	0	1
13	L:L:Q18	R:R:L240	7.99	No	Yes	0	0	4
14	L:L:R20	L:L:Y21	6.17	Yes	Yes	1	0	0
15	L:L:R20	R:R:Y99	14.4	Yes	Yes	1	0	3
16	L:L:R20	R:R:E157	9.3	Yes	Yes	1	0	4
17	L:L:R20	R:R:D177	11.91	Yes	Yes	1	0	4
18	L:L:R20	R:R:F236	5.34	Yes	Yes	1	0	4
19	L:L:R20	R:R:L240	7.29	Yes	Yes	1	0	4
20	L:L:R20	R:R:W241	4	Yes	Yes	1	0	3
21	L:L:Y21	R:R:Y99	5.96	Yes	Yes	1	0	3
22	L:L:Y21	R:R:P100	6.95	Yes	No	1	0	4
23	R:R:C251	R:R:T27	8.45	No	No	0	1	4
24	R:R:L28	R:R:T31	10.32	No	No	0	4	4
25	R:R:L30	R:R:L33	4.15	No	No	0	5	6
26	R:R:F259	R:R:L33	20.7	No	No	0	5	6
27	R:R:I258	R:R:T34	4.56	No	No	0	4	5
28	R:R:F259	R:R:T34	6.49	No	No	0	5	5
29	R:R:F259	R:R:V37	5.24	No	No	0	5	7
30	R:R:L80	R:R:S38	9.01	Yes	No	0	7	5
31	R:R:L39	R:R:L80	5.54	No	Yes	0	5	7
32	R:R:F73	R:R:L42	4.87	No	No	0	7	7
33	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
34	R:R:N45	R:R:P269	14.66	No	No	0	9	9
35	R:R:L51	R:R:V47	4.47	Yes	No	0	7	6
36	R:R:F274	R:R:V47	6.55	Yes	No	0	7	6
37	R:R:L52	R:R:V48	4.47	Yes	No	5	7	9
38	R:R:F273	R:R:V48	7.87	Yes	No	5	7	9
39	R:R:L49	R:R:L66	5.54	No	No	0	7	7
40	R:R:L51	R:R:W50	5.69	Yes	No	0	7	5
41	R:R:L51	R:R:R55	7.29	Yes	No	0	7	6
42	R:R:F273	R:R:L51	6.09	Yes	Yes	0	7	7
43	R:R:L52	R:R:R55	4.86	Yes	No	0	7	6
44	R:R:F273	R:R:L52	10.96	Yes	Yes	5	7	7
45	R:R:M56	R:R:R58	8.69	No	No	0	6	7
46	R:R:I63	R:R:R57	5.01	No	No	0	7	6
47	R:R:L66	R:R:R57	7.29	No	No	0	7	6
48	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
49	R:R:F61	R:R:I65	12.56	No	No	2	7	8
50	R:R:F61	R:R:V116	6.55	No	No	2	7	8
51	R:R:F61	R:R:Y272	8.25	No	Yes	2	7	9
52	R:R:I63	R:R:S139	12.39	No	No	0	7	9
53	R:R:A115	R:R:Y64	4	No	Yes	0	7	7
54	R:R:E119	R:R:Y64	12.35	No	Yes	0	9	7
55	R:R:V142	R:R:Y64	8.83	No	Yes	0	6	7
56	R:R:C143	R:R:Y64	4.03	No	Yes	0	7	7
57	R:R:I65	R:R:Y272	6.04	No	Yes	2	8	9
58	R:R:F112	R:R:N67	7.25	Yes	No	3	7	9
59	R:R:C143	R:R:N67	12.6	No	No	3	7	9
60	R:R:N67	R:R:W147	6.78	No	Yes	3	9	9
61	R:R:D72	R:R:L68	9.5	Yes	No	2	9	9
62	R:R:L113	R:R:L68	6.92	No	No	2	8	9
63	R:R:L68	R:R:N268	6.87	No	Yes	2	9	9
64	R:R:D72	R:R:S265	7.36	Yes	No	0	9	9
65	R:R:D72	R:R:N268	8.08	Yes	Yes	2	9	9
66	R:R:L74	R:R:V101	4.47	No	No	0	7	6
67	R:R:L74	R:R:S105	10.51	No	No	0	7	8
68	R:R:F75	R:R:Y106	7.22	Yes	Yes	0	6	7
69	R:R:F75	R:R:S261	6.61	Yes	No	0	6	7
70	R:R:F75	R:R:S265	7.93	Yes	No	0	6	9
71	R:R:L76	R:R:S265	7.51	No	No	0	7	9
72	R:R:M102	R:R:R79	11.17	No	No	0	4	6
73	R:R:F232	R:R:R79	4.28	Yes	No	0	5	6
74	R:R:I258	R:R:R79	18.79	No	No	0	4	6
75	R:R:L80	R:R:L84	5.54	Yes	No	0	7	5
76	R:R:I81	R:R:L98	9.99	No	No	0	5	4
77	R:R:L98	R:R:Y82	7.03	No	No	0	4	3
78	R:R:M102	R:R:Y82	4.79	No	No	0	4	3
79	R:R:P100	R:R:Y99	5.56	No	Yes	1	4	3
80	R:R:M103	R:R:Y99	15.57	Yes	Yes	1	2	3
81	R:R:E157	R:R:Y99	10.1	Yes	Yes	1	4	3
82	R:R:F236	R:R:Y99	9.28	Yes	Yes	1	4	3
83	R:R:F232	R:R:M103	6.22	Yes	Yes	1	5	2
84	R:R:F236	R:R:M103	7.46	Yes	Yes	1	4	2
85	R:R:F237	R:R:M103	4.98	Yes	Yes	1	5	2
86	R:R:F104	R:R:W147	7.02	Yes	Yes	0	5	9
87	R:R:F104	R:R:S150	7.93	Yes	No	0	5	8
88	R:R:F104	R:R:L151	4.87	Yes	No	0	5	4
89	R:R:F104	R:R:S154	5.28	Yes	No	0	5	6
90	R:R:F107	R:R:Y106	9.28	Yes	Yes	1	6	7
91	R:R:L110	R:R:Y106	11.72	No	Yes	0	7	7
92	R:R:F232	R:R:Y106	12.38	Yes	Yes	1	5	7
93	R:R:G233	R:R:Y106	4.35	No	Yes	1	7	7
94	R:R:F107	R:R:R153	19.24	Yes	Yes	1	6	4
95	R:R:F107	R:R:L184	8.53	Yes	No	0	6	8
96	R:R:F107	R:R:F237	5.36	Yes	Yes	1	6	5
97	R:R:A108	R:R:W147	5.19	No	Yes	0	7	9
98	R:R:L146	R:R:S111	9.01	No	No	0	7	6
99	R:R:C143	R:R:F112	4.19	No	Yes	3	7	7
100	R:R:F112	R:R:L146	6.09	Yes	No	0	7	7
101	R:R:F112	R:R:W147	14.03	Yes	Yes	3	7	9
102	R:R:L113	R:R:N268	12.36	No	Yes	2	8	9
103	R:R:L113	R:R:Y272	5.86	No	Yes	2	8	9
104	R:R:L187	R:R:S114	9.01	No	No	0	9	8
105	R:R:V116	R:R:Y272	5.05	No	Yes	2	8	9
106	R:R:R120	R:R:S117	5.27	No	Yes	0	9	9
107	R:R:L191	R:R:S117	9.01	No	Yes	0	8	9
108	R:R:S117	R:R:S194	6.52	Yes	No	0	9	8
109	R:R:S117	R:R:S195	4.89	Yes	No	0	9	8
110	R:R:S194	R:R:T118	6.4	No	No	0	8	7
111	R:R:E119	R:R:Y130	6.73	No	No	6	9	7
112	R:R:E119	R:R:R134	11.63	No	Yes	6	9	9
113	R:R:R120	R:R:T221	6.47	No	No	0	9	8
114	R:R:C121	R:R:L125	4.76	No	No	0	8	7
115	R:R:L122	R:R:W126	4.56	No	No	0	6	6
116	R:R:S123	R:R:Y130	8.9	No	No	0	8	7
117	R:R:L198	R:R:V124	5.96	Yes	No	7	8	8
118	R:R:I202	R:R:V124	4.61	Yes	No	7	6	8
119	R:R:L125	R:R:V197	4.47	No	No	0	7	4
120	R:R:L125	R:R:R201	4.86	No	No	0	7	6
121	R:R:H133	R:R:W129	4.23	No	No	0	5	5
122	R:R:R134	R:R:W129	12	Yes	No	0	9	5
123	R:R:R134	R:R:Y130	8.23	Yes	No	6	9	7
124	R:R:C132	R:R:H133	4.42	No	No	0	6	5
125	R:R:L138	R:R:R134	7.29	No	Yes	0	4	9
126	R:R:R134	R:R:S139	5.27	Yes	No	0	9	9
127	R:R:H137	R:R:P135	10.68	No	No	0	6	7
128	R:R:L138	R:R:P135	4.93	No	No	0	4	7
129	R:R:H137	R:R:V141	5.54	No	No	0	6	5
130	R:R:L138	R:R:V142	4.47	No	No	0	4	6
131	R:R:I155	R:R:L151	5.71	No	No	0	4	4
132	R:R:L152	R:R:L156	5.54	No	No	0	4	7
133	R:R:R153	R:R:S154	5.27	Yes	No	0	4	6
134	R:R:E157	R:R:R153	12.79	Yes	Yes	1	4	4
135	R:R:R153	R:R:T180	11.64	Yes	No	1	4	5
136	R:R:F237	R:R:R153	5.34	Yes	Yes	1	5	4
137	R:R:E157	R:R:F237	7	Yes	Yes	1	4	5
138	R:R:L160	R:R:S176	6.01	No	No	0	3	3
139	R:R:C173	R:R:Q174	10.68	No	No	0	9	3
140	R:R:Q174	R:R:W241	8.76	No	Yes	0	3	3
141	R:R:D177	R:R:F237	8.36	Yes	Yes	1	4	5
142	R:R:D177	R:R:L240	4.07	Yes	Yes	1	4	4
143	R:R:D177	R:R:W241	12.28	Yes	Yes	1	4	3
144	R:R:F178	R:R:W241	5.01	No	Yes	0	3	3
145	R:R:F237	R:R:T180	10.38	Yes	No	1	5	5
146	R:R:F186	R:R:W183	9.02	No	No	0	5	6
147	R:R:L187	R:R:W183	15.94	No	No	0	9	6
148	R:R:I234	R:R:L184	4.28	No	No	0	6	8
149	R:R:I185	R:R:I234	4.42	No	No	0	5	6
150	R:R:F186	R:R:V190	7.87	No	No	0	5	6
151	R:R:C188	R:R:F225	4.19	No	No	0	6	8
152	R:R:C188	R:R:L230	4.76	No	No	0	6	5
153	R:R:L191	R:R:V222	4.47	No	No	0	8	8
154	R:R:F225	R:R:L191	18.27	No	No	0	8	8
155	R:R:I200	R:R:L196	5.71	No	No	0	5	4
156	R:R:I202	R:R:L198	4.28	Yes	Yes	7	6	8
157	R:R:I218	R:R:L198	7.14	Yes	Yes	0	8	8
158	R:R:I218	R:R:L199	8.56	Yes	No	0	8	5
159	R:R:I202	R:R:L211	4.28	Yes	No	0	6	6
160	R:R:I202	R:R:L214	9.99	Yes	No	0	6	7
161	R:R:L203	R:R:Y215	7.03	No	No	0	5	6
162	R:R:I209	R:R:P210	8.47	No	No	0	4	5
163	R:R:L211	R:R:Y215	7.03	No	No	0	6	6
164	R:R:I218	R:R:L214	4.28	Yes	No	0	8	7
165	R:R:T221	R:R:Y272	11.24	No	Yes	0	8	9
166	R:R:N264	R:R:V224	4.43	No	Yes	0	9	7
167	R:R:I271	R:R:V224	4.61	No	Yes	0	8	7
168	R:R:G229	R:R:N264	6.79	No	No	0	8	9
169	R:R:I234	R:R:L230	4.28	No	No	0	6	5
170	R:R:F232	R:R:G233	4.52	Yes	No	1	5	7
171	R:R:F232	R:R:S257	5.28	Yes	No	0	5	6
172	R:R:F232	R:R:S261	7.93	Yes	No	0	5	7
173	R:R:Q235	R:R:V253	5.73	No	No	0	3	4
174	R:R:H254	R:R:Q235	8.65	No	No	0	1	3
175	R:R:Q235	R:R:S257	10.11	No	No	0	3	6
176	R:R:F236	R:R:F237	10.72	Yes	Yes	1	4	5
177	R:R:F239	R:R:L238	6.09	No	No	0	4	5
178	R:R:F239	R:R:V244	6.55	No	No	4	4	1
179	R:R:F239	R:R:L249	7.31	No	Yes	4	4	3
180	R:R:L240	R:R:W241	10.25	Yes	Yes	1	4	3
181	R:R:L249	R:R:V244	5.96	Yes	No	4	3	1
182	R:R:D245	R:R:E247	16.89	No	No	0	3	2
183	R:R:D245	R:R:V248	5.84	No	No	0	3	1
184	R:R:H252	R:R:V248	4.15	No	No	0	1	1
185	R:R:L249	R:R:V253	5.96	Yes	No	0	3	4
186	R:R:F250	R:R:L255	10.96	No	No	0	3	2
187	R:R:C251	R:R:H252	7.37	No	No	0	1	1
188	R:R:H254	R:R:I258	7.95	No	No	0	1	4
189	R:R:N264	R:R:N268	9.54	No	Yes	0	9	9
190	R:R:N268	R:R:Y272	5.81	Yes	Yes	2	9	9
191	R:R:I271	R:R:Y272	7.25	No	Yes	0	8	9
192	R:R:F273	R:R:F274	13.93	Yes	Yes	0	7	7
193	R:R:R213	R:R:V275	3.92	No	No	0	7	8
194	R:R:A71	R:R:W147	3.89	No	Yes	0	9	9
195	R:R:W126	R:R:W129	3.75	No	No	0	6	5
196	R:R:M56	R:R:R55	3.72	No	No	0	6	6
197	R:R:G78	R:R:S77	3.71	No	No	0	5	5
198	R:R:G41	R:R:V40	3.68	No	No	0	9	6
199	R:R:G276	R:R:V275	3.68	No	No	0	8	8
200	R:R:G44	R:R:T43	3.64	No	No	0	8	5
201	R:R:L198	R:R:R120	3.64	Yes	No	0	8	9
202	R:R:N59	R:R:R58	3.62	No	No	0	8	7
203	R:R:C35	R:R:S83	3.44	No	No	0	5	6
204	R:R:C121	R:R:S194	3.44	No	No	0	8	8
205	R:R:L149	R:R:W183	3.42	No	No	0	6	6
206	R:R:C228	R:R:V224	3.42	No	Yes	0	8	7
207	R:R:A69	R:R:V48	3.39	No	No	0	9	9
208	L:L:E12	L:L:W13	3.27	No	Yes	0	0	0
209	R:R:C35	R:R:I36	3.27	No	No	0	5	5
210	R:R:A267	R:R:I271	3.25	No	No	0	7	8
211	R:R:S266	R:R:V37	3.23	No	No	0	7	7
212	R:R:S83	R:R:T31	3.2	No	No	0	6	4
213	R:R:C35	R:R:L80	3.17	No	Yes	0	5	7
214	R:R:T118	R:R:V190	3.17	No	No	0	7	6
215	R:R:C188	R:R:L226	3.17	No	No	0	6	6
216	R:R:C192	R:R:L226	3.17	No	No	0	5	6
217	R:R:A70	R:R:L49	3.15	No	No	0	6	7
218	R:R:I36	R:R:V32	3.07	No	No	0	5	6
219	R:R:F112	R:R:G109	3.01	Yes	No	0	7	9
220	R:R:L42	R:R:S38	3	No	No	0	7	5
221	R:R:L76	R:R:S38	3	No	No	0	7	5
222	R:R:L52	R:R:S62	3	Yes	No	0	7	7
223	R:R:L263	R:R:S266	3	No	No	0	5	7
224	R:R:L220	R:R:V224	2.98	No	Yes	0	6	7
225	R:R:L260	R:R:V256	2.98	No	No	0	7	4
226	R:R:I97	R:R:K96	2.91	No	No	0	4	5
227	R:R:F274	R:R:P269	2.89	Yes	No	0	7	9
228	L:L:P11	L:L:R10	2.88	No	No	0	0	0
229	R:R:L160	R:R:M159	2.83	No	No	0	3	4
230	R:R:C132	R:R:R131	2.79	No	No	0	6	6
231	R:R:L223	R:R:L227	2.77	No	No	0	6	5
232	R:R:H133	R:R:I128	2.65	No	No	0	5	6
233	R:R:F75	R:R:S105	2.64	Yes	No	0	6	8
234	R:R:F237	R:R:V181	2.62	Yes	No	0	5	5
235	R:R:C54	R:R:W50	2.61	No	No	0	5	5
236	R:R:R213	R:R:R279	2.13	No	No	0	7	7
237	R:R:G229	R:R:P231	2.03	No	No	0	8	9
238	R:R:C192	R:R:G193	1.96	No	No	0	5	4
239	R:R:C204	R:R:G205	1.96	No	No	0	5	5
240	L:L:Y21	R:R:W158	1.93	Yes	No	0	0	4
241	R:R:G41	R:R:S266	1.86	No	No	0	9	7
242	R:R:G44	R:R:V47	1.84	No	No	0	8	6
243	R:R:G78	R:R:I81	1.76	No	No	0	5	5
244	R:R:G193	R:R:L196	1.71	No	No	0	4	4
245	R:R:A262	R:R:V37	1.7	No	No	0	6	7
246	R:R:V189	R:R:V190	1.6	No	No	0	4	6
247	R:R:T212	R:R:V216	1.59	No	No	0	5	7
248	R:R:C228	R:R:L260	1.59	No	No	0	8	7
249	R:R:T217	R:R:T221	1.57	No	No	0	7	8
250	R:R:I97	R:R:V101	1.54	No	No	0	4	6
251	R:R:L85	R:R:S95	1.5	No	No	0	4	7
252	R:R:L255	R:R:T27	1.47	No	No	0	2	4
253	R:R:D177	R:R:S176	1.47	Yes	No	0	4	3
254	R:R:Q26	R:R:S29	1.44	No	No	0	1	4
255	R:R:I209	R:R:L211	1.43	No	No	0	4	6
256	R:R:I218	R:R:L219	1.43	Yes	No	0	8	5
257	R:R:I242	R:R:L238	1.43	No	No	0	1	5
258	R:R:Q26	R:R:T27	1.42	No	No	0	1	4
259	R:R:L145	R:R:L146	1.38	No	No	0	4	7
260	R:R:L156	R:R:L160	1.38	No	No	0	7	3
261	R:R:L226	R:R:L227	1.38	No	No	0	6	5
262	R:R:K25	R:R:Q26	1.36	No	No	0	2	1
263	R:R:P127	R:R:W126	1.35	No	No	0	9	6
264	R:R:C251	R:R:Y24	1.34	No	No	0	1	3
265	R:R:F178	R:R:T175	1.3	No	No	0	3	4
266	R:R:R213	R:R:T217	1.29	No	No	0	7	7
267	R:R:F274	R:R:I270	1.26	Yes	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W13	17.4425	4	1	0
2	L:L:W14	13.5275	4	1	0
3	L:L:Y17	13.748	5	0	0
4	L:L:R20	8.34429	7	1	0
5	L:L:Y21	5.2525	4	1	0
6	R:R:L51	5.885	4	0	7
7	R:R:L52	5.8225	4	5	7
8	R:R:Y64	7.3025	4	0	7
9	R:R:D72	7.9175	4	2	9
10	R:R:F75	6.1	4	0	6
11	R:R:L80	5.815	4	0	7
12	R:R:Y99	10.145	6	1	3
13	R:R:M103	8.5575	4	1	2
14	R:R:F104	6.275	4	0	5
15	R:R:Y106	8.99	5	1	7
16	R:R:F107	10.6025	4	1	6
17	R:R:F112	6.914	5	3	7
18	R:R:S117	6.4225	4	0	9
19	R:R:R134	8.095	6	6	9
20	R:R:W147	7.382	5	3	9
21	R:R:R153	10.856	5	1	4
22	R:R:E157	9.7975	4	1	4
23	R:R:D177	7.618	5	1	4
24	R:R:L198	5.255	4	7	8
25	R:R:I202	5.79	4	7	6
26	R:R:I218	5.3525	4	0	8
27	R:R:V224	3.86	4	0	7
28	R:R:F232	6.76833	6	1	5
29	R:R:F236	8.2	4	1	4
30	R:R:F237	6.845	8	1	5
31	R:R:L240	9.336	5	1	4
32	R:R:W241	7.81	6	1	3
33	R:R:L249	5.98	4	4	3
34	R:R:N268	8.532	5	2	9
35	R:R:Y272	7.07143	7	2	9
36	R:R:F273	9.7125	4	5	7
37	R:R:F274	6.1575	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:W14	R:R:L240	10.1354	17.08	Yes	Yes	1	0	4
2	L:L:Q18	L:L:Y17	19.9528	19.16	No	Yes	0	0	0
3	L:L:Q18	R:R:L240	21.1703	7.99	No	Yes	0	0	4
4	L:L:Y17	R:R:F250	32.237	7.22	Yes	No	0	0	3
5	L:L:Y17	R:R:H254	28.5572	30.49	Yes	No	0	0	1
6	L:L:R20	R:R:L240	10.8032	7.29	Yes	Yes	1	0	4
7	L:L:R20	R:R:E157	14.9737	9.3	Yes	Yes	1	0	4
8	R:R:D177	R:R:L240	18.6217	4.07	Yes	Yes	1	4	4
9	R:R:D177	R:R:W241	11.2302	12.28	Yes	Yes	1	4	3
10	R:R:F250	R:R:L255	29.6974	10.96	No	No	0	3	2
11	R:R:L255	R:R:T27	27.008	1.47	No	No	0	2	4
12	R:R:C251	R:R:T27	16.5046	8.45	No	No	0	1	4
13	R:R:D177	R:R:F237	35.5488	8.36	Yes	Yes	1	4	5
14	R:R:F107	R:R:F237	25.2499	5.36	Yes	Yes	1	6	5
15	R:R:F107	R:R:Y106	59.4767	9.28	Yes	Yes	1	6	7
16	R:R:F75	R:R:Y106	75.7541	7.22	Yes	Yes	0	6	7
17	R:R:F75	R:R:S265	100	7.93	Yes	No	0	6	9
18	R:R:L76	R:R:S265	20.7251	7.51	No	No	0	7	9
19	R:R:L76	R:R:S38	19.185	3	No	No	0	7	5
20	R:R:L80	R:R:S38	14.5103	9.01	Yes	No	0	7	5
21	R:R:H254	R:R:I258	17.0452	7.95	No	No	0	1	4
22	R:R:I258	R:R:T34	20.6206	4.56	No	No	0	4	5
23	R:R:F259	R:R:T34	18.5989	6.49	No	No	0	5	5
24	R:R:F259	R:R:V37	12.4796	5.24	No	No	0	5	7
25	R:R:D72	R:R:S265	88.8061	7.36	Yes	No	0	9	9
26	R:R:D72	R:R:N45	46.4701	6.73	Yes	No	0	9	9
27	R:R:N45	R:R:P269	45.0527	14.66	No	No	0	9	9
28	R:R:F274	R:R:P269	43.6262	2.89	Yes	No	0	7	9
29	R:R:F274	R:R:V47	15.7369	6.55	Yes	No	0	7	6
30	R:R:L51	R:R:V47	11.1576	4.47	Yes	No	0	7	6
31	R:R:F273	R:R:F274	25.1408	13.93	Yes	Yes	0	7	7
32	R:R:F273	R:R:L51	11.1212	6.09	Yes	Yes	0	7	7
33	R:R:E157	R:R:R153	16.65	12.79	Yes	Yes	1	4	4
34	R:R:R153	R:R:S154	87.5522	5.27	Yes	No	0	4	6
35	R:R:F104	R:R:S154	86.5482	5.28	Yes	No	0	5	6
36	R:R:F104	R:R:W147	82.4414	7.02	Yes	Yes	0	5	9
37	R:R:N67	R:R:W147	36.8254	6.78	No	Yes	3	9	9
38	R:R:C143	R:R:N67	35.835	12.6	No	No	3	7	9
39	R:R:C143	R:R:Y64	69.5666	4.03	No	Yes	0	7	7
40	R:R:E119	R:R:Y64	50.686	12.35	No	Yes	0	9	7
41	R:R:E119	R:R:R134	43.3173	11.63	No	Yes	6	9	9
42	R:R:R134	R:R:S139	16.8499	5.27	Yes	No	0	9	9
43	R:R:I63	R:R:S139	14.0787	12.39	No	No	0	7	9
44	R:R:I63	R:R:R57	11.2802	5.01	No	No	0	7	6
45	R:R:F237	R:R:R153	22.9965	5.34	Yes	Yes	1	5	4
46	R:R:F112	R:R:W147	42.4359	14.03	Yes	Yes	3	7	9
47	R:R:C143	R:R:F112	36.3256	4.19	No	Yes	3	7	7
48	R:R:L51	R:R:R55	12.7158	7.29	Yes	No	0	7	6
49	R:R:M56	R:R:R55	14.2786	3.72	No	No	0	6	6
50	R:R:D72	R:R:N268	56.2375	8.08	Yes	Yes	2	9	9
51	R:R:N268	R:R:Y272	43.8534	5.81	Yes	Yes	2	9	9
52	R:R:V142	R:R:Y64	13.6607	8.83	No	Yes	0	6	7
53	R:R:F232	R:R:M103	18.3673	6.22	Yes	Yes	1	5	2
54	R:R:F232	R:R:S261	29.8246	7.93	Yes	No	0	5	7
55	R:R:F237	R:R:M103	10.7214	4.98	Yes	Yes	1	5	2
56	R:R:I258	R:R:R79	35.3171	18.79	No	No	0	4	6
57	R:R:M102	R:R:R79	13.6516	11.17	No	No	0	4	6
58	R:R:F232	R:R:R79	48.3827	4.28	Yes	No	0	5	6
59	R:R:M102	R:R:Y82	11.3983	4.79	No	No	0	4	3
60	R:R:F107	R:R:L184	34.4948	8.53	Yes	No	0	6	8
61	R:R:I234	R:R:L184	33.5363	4.28	No	No	0	6	8
62	R:R:I234	R:R:L230	31.7009	4.28	No	No	0	6	5
63	R:R:C188	R:R:L230	30.8741	4.76	No	No	0	6	5
64	R:R:C188	R:R:F225	25.3135	4.19	No	No	0	6	8
65	R:R:F225	R:R:L191	24.7819	18.27	No	No	0	8	8
66	R:R:L191	R:R:S117	23.8824	9.01	No	Yes	0	8	9
67	R:R:S117	R:R:S194	20.4479	6.52	Yes	No	0	9	8
68	R:R:S194	R:R:T118	12.8475	6.4	No	No	0	8	7
69	R:R:T118	R:R:V190	11.262	3.17	No	No	0	7	6
70	R:R:T221	R:R:Y272	38.6426	11.24	No	Yes	0	8	9
71	R:R:R120	R:R:T221	31.3965	6.47	No	No	0	9	8
72	R:R:R120	R:R:S117	20.5842	5.27	No	Yes	0	9	9
73	R:R:R134	R:R:W129	22.4196	12	Yes	No	0	9	5
74	R:R:L198	R:R:R120	25.4089	3.64	Yes	No	0	8	9
75	R:R:I202	R:R:L198	13.7334	4.28	Yes	Yes	7	6	8
76	R:R:H133	R:R:W129	11.2802	4.23	No	No	0	5	5
77	R:R:L138	R:R:V142	11.0167	4.47	No	No	0	4	6
78	R:R:C188	R:R:L226	10.4261	3.17	No	No	0	6	6
79	R:R:N264	R:R:N268	11.6436	9.54	No	Yes	0	9	9
80	R:R:H254	R:R:Q235	14.3649	8.65	No	No	0	1	3
81	R:R:Q235	R:R:S257	23.0919	10.11	No	No	0	3	6
82	R:R:F232	R:R:S257	25.0681	5.28	Yes	No	0	5	6
83	R:R:C251	R:R:H252	11.044	7.37	No	No	0	1	1
84	R:R:F232	R:R:Y106	40.8868	12.38	Yes	Yes	1	5	7
85	R:R:F75	R:R:S261	29.3658	6.61	Yes	No	0	6	7
86	R:R:F107	R:R:R153	53.1437	19.24	Yes	Yes	1	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:W13	R:R:H243	45.49	1	Yes	No	0	1	0	1
L:L:W14	R:R:L240	17.08	1	Yes	Yes	0	4	0	1
L:L:W14	R:R:W241	6.56	1	Yes	Yes	0	3	0	1
L:L:M15	R:R:R246	17.37	0	No	No	0	2	0	1
L:L:Y17	R:R:L249	4.69	0	Yes	Yes	0	3	0	1
L:L:Y17	R:R:F250	7.22	0	Yes	No	0	3	0	1
L:L:Y17	R:R:H254	30.49	0	Yes	No	0	1	0	1
L:L:Q18	R:R:L240	7.99	0	No	Yes	0	4	0	1
L:L:R20	R:R:Y99	14.4	1	Yes	Yes	0	3	0	1
L:L:R20	R:R:E157	9.3	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:D177	11.91	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:F236	5.34	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:L240	7.29	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:W241	4	1	Yes	Yes	0	3	0	1
L:L:Y21	R:R:Y99	5.96	1	Yes	Yes	0	3	0	1
L:L:Y21	R:R:P100	6.95	1	Yes	No	0	4	0	1
R:R:P100	R:R:Y99	5.56	1	No	Yes	4	3	1	1
R:R:M103	R:R:Y99	15.57	1	Yes	Yes	2	3	2	1
R:R:E157	R:R:Y99	10.1	1	Yes	Yes	4	3	1	1
R:R:F236	R:R:Y99	9.28	1	Yes	Yes	4	3	1	1
R:R:F236	R:R:M103	7.46	1	Yes	Yes	4	2	1	2
R:R:F237	R:R:M103	4.98	1	Yes	Yes	5	2	2	2
R:R:E157	R:R:R153	12.79	1	Yes	Yes	4	4	1	2
R:R:F237	R:R:R153	5.34	1	Yes	Yes	5	4	2	2
R:R:E157	R:R:F237	7	1	Yes	Yes	4	5	1	2
R:R:Q174	R:R:W241	8.76	0	No	Yes	3	3	2	1
R:R:D177	R:R:F237	8.36	1	Yes	Yes	4	5	1	2
R:R:D177	R:R:L240	4.07	1	Yes	Yes	4	4	1	1
R:R:D177	R:R:W241	12.28	1	Yes	Yes	4	3	1	1
R:R:F178	R:R:W241	5.01	0	No	Yes	3	3	2	1
R:R:Q235	R:R:V253	5.73	0	No	No	3	4	2	2
R:R:H254	R:R:Q235	8.65	0	No	No	1	3	1	2
R:R:F236	R:R:F237	10.72	1	Yes	Yes	4	5	1	2
R:R:F239	R:R:V244	6.55	4	No	No	4	1	2	2
R:R:F239	R:R:L249	7.31	4	No	Yes	4	3	2	1
R:R:L240	R:R:W241	10.25	1	Yes	Yes	4	3	1	1
R:R:L249	R:R:V244	5.96	4	Yes	No	3	1	1	2
R:R:L249	R:R:V253	5.96	4	Yes	No	3	4	1	2
R:R:F250	R:R:L255	10.96	0	No	No	3	2	1	2
R:R:H254	R:R:I258	7.95	0	No	No	1	4	1	2
L:L:Y21	R:R:W158	1.93	1	Yes	No	0	4	0	1
R:R:D177	R:R:S176	1.47	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JGF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4
Number of Linked Nodes	232
Number of Links	267
Number of Hubs	37
Number of Links mediated by Hubs	134
Number of Communities	7
Number of Nodes involved in Communities	44
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	51288
Length Of Smallest Path	3
Average Path Length	14.508
Length of Longest Path	30
Minimum Path Strength	1.39
Average Path Strength	7.78641
Maximum Path Strength	29.5
Minimum Path Correlation	0.7
Average Path Correlation	0.921653
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	41.4911
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.8295
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8JGF_nogp_Chain_R Y K Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C G S R K I P L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JGF	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGF (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/β1/γ2	3	2024-01-10	10.1038/s41467-023-40705-z
	8JGG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		3	2024-01-10	10.1038/s41467-023-40705-z
	8JGB	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/β1/γ2	2.84	2024-01-10	10.1038/s41467-023-40705-z
	8JGB (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-		2.84	2024-01-10	10.1038/s41467-023-40705-z
	8HJ5	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-05-31	10.1371/journal.pbio.3001975
	8HJ5 (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3	2023-05-31	10.1371/journal.pbio.3001975
	8DWH	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWH (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382		2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWC	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2022-11-02	10.1038/s41589-022-01173-6
	8DWC (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-		2.87	2022-11-02	10.1038/s41589-022-01173-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JGF_nogp.zip

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