psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F15	L:L:R17	3.21	No	Yes	4	0	0
2	L:L:F15	R:R:F236	3.22	No	Yes	4	0	4
3	L:L:R17	R:R:L160	7.29	Yes	No	0	0	3
4	L:L:R17	R:R:F236	4.28	Yes	Yes	4	0	4
5	L:L:R17	R:R:L240	12.15	Yes	No	4	0	4
6	R:R:L28	R:R:S29	3	No	No	0	4	4
7	R:R:L28	R:R:T31	4.42	No	No	0	4	4
8	R:R:L255	R:R:L28	12.46	No	No	0	2	4
9	R:R:L30	R:R:S29	6.01	No	No	0	5	4
10	R:R:L30	R:R:L33	4.15	No	No	0	5	6
11	R:R:F259	R:R:L33	4.87	No	No	0	5	6
12	R:R:R79	R:R:T34	7.76	Yes	No	1	6	5
13	R:R:A262	R:R:T34	3.36	No	No	1	6	5
14	R:R:F259	R:R:V37	5.24	No	No	0	5	7
15	R:R:L76	R:R:S38	3	Yes	No	0	7	5
16	R:R:F73	R:R:L42	10.96	No	No	0	7	7
17	R:R:L42	R:R:L80	4.15	No	No	0	7	7
18	R:R:A69	R:R:N45	4.69	No	No	0	9	9
19	R:R:D72	R:R:N45	14.81	Yes	No	0	9	9
20	R:R:N45	R:R:P269	6.52	No	No	0	9	9
21	R:R:A46	R:R:W50	5.19	No	No	0	6	5
22	R:R:L51	R:R:V47	2.98	No	No	0	7	6
23	R:R:P269	R:R:V48	7.07	No	No	0	9	9
24	R:R:F273	R:R:V48	14.42	No	No	2	7	9
25	R:R:F274	R:R:V48	3.93	No	No	2	7	9
26	R:R:L52	R:R:M56	4.24	Yes	No	0	7	6
27	R:R:L52	R:R:S62	7.51	Yes	No	0	7	7
28	R:R:L52	R:R:L66	9.69	Yes	No	2	7	7
29	R:R:F273	R:R:L52	8.53	No	Yes	2	7	7
30	R:R:I63	R:R:R57	6.26	No	No	0	7	6
31	R:R:L66	R:R:R57	9.72	No	No	0	7	6
32	R:R:F61	R:R:N59	12.08	No	No	0	7	8
33	R:R:N59	R:R:S62	7.45	No	No	0	8	7
34	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
35	R:R:F61	R:R:I65	8.79	No	No	0	7	8
36	R:R:I63	R:R:S139	9.29	No	No	0	7	9
37	R:R:A115	R:R:Y64	2.67	No	Yes	0	7	7
38	R:R:V116	R:R:Y64	6.31	No	Yes	0	8	7
39	R:R:E119	R:R:Y64	8.98	No	Yes	0	9	7
40	R:R:S139	R:R:Y64	5.09	No	Yes	0	9	7
41	R:R:V142	R:R:Y64	3.79	No	Yes	0	6	7
42	R:R:C143	R:R:Y64	4.03	No	Yes	0	7	7
43	R:R:I65	R:R:V116	3.07	No	No	0	8	8
44	R:R:I65	R:R:Y272	4.84	No	Yes	0	8	9
45	R:R:F112	R:R:N67	9.67	Yes	No	5	7	9
46	R:R:C143	R:R:N67	7.87	No	No	5	7	9
47	R:R:N67	R:R:W147	4.52	No	Yes	5	9	9
48	R:R:L113	R:R:L68	6.92	No	No	1	8	9
49	R:R:L68	R:R:N268	5.49	No	No	1	9	9
50	R:R:A71	R:R:W147	3.89	No	Yes	0	9	9
51	R:R:D72	R:R:L76	5.43	Yes	Yes	1	9	7
52	R:R:D72	R:R:S265	10.31	Yes	No	1	9	9
53	R:R:D72	R:R:N268	5.39	Yes	No	1	9	9
54	R:R:F73	R:R:S77	3.96	No	No	0	7	5
55	R:R:L74	R:R:S105	3	No	No	0	7	8
56	R:R:F75	R:R:R79	6.41	Yes	Yes	1	6	6
57	R:R:F75	R:R:M102	4.98	Yes	No	0	6	4
58	R:R:F75	R:R:S105	3.96	Yes	No	0	6	8
59	R:R:F75	R:R:Y106	3.09	Yes	Yes	1	6	7
60	R:R:F75	R:R:S261	3.96	Yes	No	1	6	7
61	R:R:F75	R:R:S265	2.64	Yes	No	1	6	9
62	R:R:L76	R:R:S265	6.01	Yes	No	1	7	9
63	R:R:G78	R:R:I81	3.53	No	No	0	5	5
64	R:R:I258	R:R:R79	11.27	No	Yes	0	4	6
65	R:R:A262	R:R:R79	4.15	No	Yes	1	6	6
66	R:R:I81	R:R:L84	4.28	No	No	0	5	5
67	R:R:L85	R:R:Y82	8.21	No	No	0	4	3
68	R:R:L84	R:R:S83	4.5	No	No	0	5	6
69	R:R:I97	R:R:V101	4.61	No	No	0	4	6
70	R:R:P100	R:R:Y99	5.56	No	Yes	0	4	3
71	R:R:M103	R:R:Y99	4.79	No	Yes	0	2	3
72	R:R:E157	R:R:Y99	12.35	No	Yes	0	4	3
73	R:R:F236	R:R:Y99	3.09	Yes	Yes	0	4	3
74	R:R:M102	R:R:M103	5.78	No	No	0	4	2
75	R:R:F104	R:R:W147	6.01	No	Yes	0	5	9
76	R:R:F104	R:R:S150	6.61	No	No	0	5	8
77	R:R:F107	R:R:Y106	10.32	Yes	Yes	0	6	7
78	R:R:L110	R:R:Y106	9.38	No	Yes	0	7	7
79	R:R:F232	R:R:Y106	8.25	No	Yes	1	5	7
80	R:R:G233	R:R:Y106	4.35	No	Yes	0	7	7
81	R:R:S261	R:R:Y106	5.09	No	Yes	1	7	7
82	R:R:F107	R:R:R153	7.48	Yes	No	0	6	4
83	R:R:F107	R:R:L184	6.09	Yes	No	0	6	8
84	R:R:F107	R:R:F237	4.29	Yes	Yes	0	6	5
85	R:R:A108	R:R:W147	3.89	No	Yes	0	7	9
86	R:R:A108	R:R:S150	3.42	No	No	0	7	8
87	R:R:L146	R:R:S111	3	No	No	0	7	6
88	R:R:C143	R:R:F112	4.19	No	Yes	5	7	7
89	R:R:F112	R:R:L146	10.96	Yes	No	0	7	7
90	R:R:F112	R:R:W147	11.02	Yes	Yes	5	7	9
91	R:R:L113	R:R:N268	2.75	No	No	1	8	9
92	R:R:L113	R:R:Y272	5.86	No	Yes	1	8	9
93	R:R:L187	R:R:S114	4.5	No	No	0	9	8
94	R:R:L191	R:R:S114	4.5	No	No	0	8	8
95	R:R:L191	R:R:S117	4.5	No	No	0	8	9
96	R:R:S117	R:R:S195	3.26	No	No	0	9	8
97	R:R:E119	R:R:L122	3.98	No	No	0	9	6
98	R:R:E119	R:R:Y130	6.73	No	Yes	0	9	7
99	R:R:L198	R:R:R120	3.64	No	No	0	8	9
100	R:R:C121	R:R:L125	3.17	No	No	0	8	7
101	R:R:C121	R:R:V197	3.42	No	No	0	8	4
102	R:R:S123	R:R:Y130	7.63	No	Yes	0	8	7
103	R:R:L198	R:R:V124	4.47	No	No	0	8	8
104	R:R:L125	R:R:W126	6.83	No	No	0	7	6
105	R:R:W129	R:R:Y130	5.79	No	Yes	3	5	7
106	R:R:H133	R:R:W129	4.23	No	No	0	5	5
107	R:R:R134	R:R:W129	6	Yes	No	3	9	5
108	R:R:R134	R:R:Y130	7.2	Yes	Yes	3	9	7
109	R:R:P135	R:R:R134	2.88	No	Yes	3	7	9
110	R:R:L138	R:R:R134	13.36	No	Yes	3	4	9
111	R:R:L138	R:R:P135	6.57	No	No	3	4	7
112	R:R:H137	R:R:T136	2.74	No	No	0	6	4
113	R:R:A140	R:R:H137	2.93	No	No	0	5	6
114	R:R:L138	R:R:V142	2.98	No	No	0	4	6
115	R:R:I155	R:R:L151	5.71	No	No	0	4	4
116	R:R:E157	R:R:R153	6.98	No	No	0	4	4
117	R:R:R153	R:R:T180	5.17	No	No	0	4	5
118	R:R:L156	R:R:M159	5.65	No	No	0	7	4
119	R:R:C161	R:R:L160	3.17	No	No	0	4	3
120	R:R:Q174	R:R:T175	2.83	No	No	0	3	4
121	R:R:F178	R:R:T175	5.19	No	No	0	3	4
122	R:R:D177	R:R:S176	2.94	No	No	0	4	3
123	R:R:D177	R:R:F237	13.14	No	Yes	0	4	5
124	R:R:D177	R:R:L240	2.71	No	No	0	4	4
125	R:R:F237	R:R:T180	7.78	Yes	No	0	5	5
126	R:R:F186	R:R:W183	4.01	No	No	0	5	6
127	R:R:L187	R:R:W183	6.83	No	No	0	9	6
128	R:R:L184	R:R:L230	2.77	No	Yes	0	8	5
129	R:R:F186	R:R:V190	7.87	No	No	0	5	6
130	R:R:C188	R:R:L226	3.17	No	No	0	6	6
131	R:R:C188	R:R:L230	3.17	No	Yes	0	6	5
132	R:R:F225	R:R:L191	18.27	No	No	0	8	8
133	R:R:I218	R:R:S195	4.64	Yes	No	0	8	8
134	R:R:S195	R:R:V222	3.23	No	No	0	8	8
135	R:R:I200	R:R:V197	3.07	No	No	0	5	4
136	R:R:I218	R:R:L198	4.28	Yes	No	0	8	8
137	R:R:L199	R:R:L203	6.92	No	No	0	5	5
138	R:R:L199	R:R:Y215	4.69	No	No	0	5	6
139	R:R:I218	R:R:L199	8.56	Yes	No	0	8	5
140	R:R:C204	R:R:I200	3.27	No	No	0	5	5
141	R:R:I202	R:R:L203	2.85	No	No	6	6	5
142	R:R:I202	R:R:L211	2.85	No	No	6	6	6
143	R:R:L203	R:R:L211	4.15	No	No	6	5	6
144	R:R:I218	R:R:L214	2.85	Yes	No	0	8	7
145	R:R:L219	R:R:Y215	8.21	No	No	0	5	6
146	R:R:I271	R:R:T221	3.04	Yes	No	1	8	8
147	R:R:T221	R:R:Y272	6.24	No	Yes	1	8	9
148	R:R:L223	R:R:L227	4.15	No	No	0	6	5
149	R:R:N264	R:R:V224	2.96	No	No	0	9	7
150	R:R:F225	R:R:L226	6.09	No	No	0	8	6
151	R:R:F225	R:R:L230	4.87	No	Yes	0	8	5
152	R:R:C228	R:R:L260	6.35	No	No	0	8	7
153	R:R:C228	R:R:N264	4.72	No	No	0	8	9
154	R:R:G229	R:R:N264	3.39	No	No	0	8	9
155	R:R:F232	R:R:I258	3.77	No	No	0	5	4
156	R:R:F232	R:R:S261	10.57	No	No	1	5	7
157	R:R:L238	R:R:Q235	2.66	No	No	7	5	3
158	R:R:F239	R:R:Q235	11.71	No	No	7	4	3
159	R:R:F236	R:R:F237	16.08	Yes	Yes	0	4	5
160	R:R:F236	R:R:L240	9.74	Yes	No	4	4	4
161	R:R:F239	R:R:L238	12.18	No	No	7	4	5
162	R:R:C251	R:R:F250	9.78	No	No	0	1	3
163	R:R:H254	R:R:I258	3.98	No	No	0	1	4
164	R:R:A267	R:R:I270	3.25	No	No	0	7	6
165	R:R:I270	R:R:I271	4.42	No	Yes	0	6	8
166	R:R:I271	R:R:Y272	13.3	Yes	Yes	1	8	9
167	R:R:F273	R:R:F274	5.36	No	No	2	7	7
168	R:R:F274	R:R:S277	5.28	No	No	0	7	6
169	R:R:F259	R:R:T34	2.59	No	No	0	5	5
170	R:R:V47	R:R:W50	2.45	No	No	0	6	5
171	R:R:L125	R:R:R201	2.43	No	No	0	7	6
172	R:R:I155	R:R:W158	2.35	No	No	0	4	4
173	R:R:L49	R:R:W50	2.28	No	No	0	7	5
174	R:R:L122	R:R:W126	2.28	No	No	0	6	6
175	R:R:G41	R:R:G44	2.11	Yes	No	0	9	8
176	R:R:G229	R:R:P231	2.03	No	No	0	8	9
177	L:L:R14	R:R:W241	2	No	No	0	0	3
178	R:R:C161	R:R:G162	1.96	No	No	0	4	2
179	R:R:C192	R:R:G193	1.96	No	No	0	5	4
180	R:R:A108	R:R:G109	1.95	No	No	0	7	9
181	R:R:G41	R:R:S266	1.86	Yes	No	0	9	7
182	R:R:G78	R:R:S77	1.86	No	No	0	5	5
183	R:R:G41	R:R:V40	1.84	Yes	No	0	9	6
184	R:R:G276	R:R:V275	1.84	No	No	0	8	8
185	R:R:G44	R:R:T43	1.82	No	No	0	8	5
186	R:R:P100	R:R:S154	1.78	No	No	0	4	6
187	R:R:C35	R:R:V32	1.71	No	No	0	5	6
188	R:R:G41	R:R:L76	1.71	Yes	Yes	0	9	7
189	R:R:G53	R:R:L52	1.71	No	Yes	2	5	7
190	R:R:G53	R:R:L66	1.71	No	No	2	5	7
191	R:R:C188	R:R:V189	1.71	No	No	0	6	4
192	R:R:C192	R:R:V222	1.71	No	No	0	5	8
193	R:R:G193	R:R:L196	1.71	No	No	0	4	4
194	R:R:A267	R:R:S266	1.71	No	No	0	7	7
195	R:R:I128	R:R:P127	1.69	No	No	0	6	9
196	R:R:A46	R:R:T43	1.68	No	No	0	6	5
197	R:R:C132	R:R:I128	1.64	No	No	0	6	6
198	R:R:L230	R:R:P231	1.64	Yes	No	0	5	9
199	R:R:S117	R:R:S194	1.63	No	No	0	9	8
200	R:R:S257	R:R:V253	1.62	No	No	0	6	4
201	R:R:S194	R:R:T118	1.6	No	No	0	8	7
202	R:R:V141	R:R:V142	1.6	No	No	0	5	6
203	R:R:C35	R:R:L80	1.59	No	No	0	5	7
204	R:R:A70	R:R:L49	1.58	No	No	0	6	7
205	R:R:T217	R:R:T221	1.57	No	No	0	7	8
206	R:R:I179	R:R:S176	1.55	No	No	0	5	3
207	R:R:I36	R:R:V37	1.54	No	No	0	5	7
208	R:R:L42	R:R:S38	1.5	No	No	0	7	5
209	R:R:L263	R:R:S266	1.5	No	No	0	5	7
210	R:R:L74	R:R:V101	1.49	No	No	0	7	6
211	R:R:L211	R:R:T212	1.47	No	No	0	6	5
212	R:R:C251	R:R:H254	1.47	No	No	0	1	1
213	R:R:I155	R:R:L156	1.43	No	No	0	4	7
214	R:R:I185	R:R:L230	1.43	No	Yes	0	5	5
215	R:R:I271	R:R:L220	1.43	Yes	No	0	8	6
216	R:R:F237	R:R:V181	1.31	Yes	No	0	5	5
217	R:R:R213	R:R:T212	1.29	No	No	0	7	5
218	R:R:V216	R:R:Y215	1.26	No	No	0	7	6
219	R:R:L149	R:R:W183	1.14	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R17	6.7325	4	4	0
2	R:R:G41	1.88	4	0	9
3	R:R:L52	6.336	5	2	7
4	R:R:Y64	5.145	6	0	7
5	R:R:D72	8.985	4	1	9
6	R:R:F75	4.17333	6	1	6
7	R:R:L76	4.0375	4	1	7
8	R:R:R79	7.3975	4	1	6
9	R:R:Y99	6.4475	4	0	3
10	R:R:Y106	6.74667	6	1	7
11	R:R:F107	7.045	4	0	6
12	R:R:F112	8.96	4	5	7
13	R:R:Y130	6.8375	4	3	7
14	R:R:R134	6.718	5	3	9
15	R:R:W147	5.866	5	5	9
16	R:R:I218	5.0825	4	0	8
17	R:R:L230	2.776	5	0	5
18	R:R:F236	7.282	5	4	4
19	R:R:F237	8.52	5	0	5
20	R:R:I271	5.5475	4	1	8
21	R:R:Y272	7.56	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F236	R:R:Y99	10.3384	3.09	Yes	Yes	0	4	3
2	R:R:M103	R:R:Y99	13.5242	4.79	No	Yes	0	2	3
3	R:R:M102	R:R:M103	14.3467	5.78	No	No	0	4	2
4	R:R:F75	R:R:M102	15.95	4.98	Yes	No	0	6	4
5	R:R:F75	R:R:R79	26.0906	6.41	Yes	Yes	1	6	6
6	R:R:R79	R:R:T34	18.7298	7.76	Yes	No	1	6	5
7	R:R:F259	R:R:T34	17.3451	2.59	No	No	0	5	5
8	R:R:F259	R:R:L33	11.6085	4.87	No	No	0	5	6
9	R:R:F236	R:R:F237	13.899	16.08	Yes	Yes	0	4	5
10	R:R:F107	R:R:F237	25.0807	4.29	Yes	Yes	0	6	5
11	R:R:F107	R:R:Y106	77.8553	10.32	Yes	Yes	0	6	7
12	R:R:F75	R:R:Y106	76.8974	3.09	Yes	Yes	1	6	7
13	R:R:F75	R:R:S265	100	2.64	Yes	No	1	6	9
14	R:R:L76	R:R:S265	27.6002	6.01	Yes	No	1	7	9
15	R:R:L76	R:R:S38	21.7491	3	Yes	No	0	7	5
16	R:R:L42	R:R:S38	19.8751	1.5	No	No	0	7	5
17	R:R:F73	R:R:L42	12.1707	10.96	No	No	0	7	7
18	R:R:D72	R:R:S265	72.3477	10.31	Yes	No	1	9	9
19	R:R:D72	R:R:N45	20.4269	14.81	Yes	No	0	9	9
20	R:R:N45	R:R:P269	16.887	6.52	No	No	0	9	9
21	R:R:G41	R:R:L76	24.3311	1.71	Yes	Yes	0	9	7
22	R:R:G41	R:R:G44	19.9792	2.11	Yes	No	0	9	8
23	R:R:G44	R:R:T43	17.5534	1.82	No	No	0	8	5
24	R:R:A46	R:R:T43	15.1067	1.68	No	No	0	6	5
25	R:R:A46	R:R:W50	12.6392	5.19	No	No	0	6	5
26	R:R:P269	R:R:V48	15.5544	7.07	No	No	0	9	9
27	R:R:F273	R:R:V48	11.7231	14.42	No	No	2	7	9
28	R:R:F273	R:R:L52	12.1916	8.53	No	Yes	2	7	7
29	R:R:D72	R:R:N268	71.8688	5.39	Yes	No	1	9	9
30	R:R:L113	R:R:N268	69.5783	2.75	No	No	1	8	9
31	R:R:L113	R:R:Y272	69.4326	5.86	No	Yes	1	8	9
32	R:R:I65	R:R:Y272	73.3368	4.84	No	Yes	0	8	9
33	R:R:I65	R:R:V116	69.9531	3.07	No	No	0	8	8
34	R:R:V116	R:R:Y64	68.8079	6.31	No	Yes	0	8	7
35	R:R:E119	R:R:Y64	28.1104	8.98	No	Yes	0	9	7
36	R:R:E119	R:R:Y130	12.1083	6.73	No	Yes	0	9	7
37	R:R:V142	R:R:Y64	11.3899	3.79	No	Yes	0	6	7
38	R:R:C143	R:R:Y64	37.5742	4.03	No	Yes	0	7	7
39	R:R:C143	R:R:F112	19.8751	4.19	No	Yes	5	7	7
40	R:R:C143	R:R:N67	15.898	7.87	No	No	5	7	9
41	R:R:N67	R:R:W147	13.9719	4.52	No	Yes	5	9	9
42	R:R:F112	R:R:W147	14.1281	11.02	Yes	Yes	5	7	9
43	R:R:F73	R:R:S77	10.1926	3.96	No	No	0	7	5
44	R:R:A108	R:R:W147	12.1291	3.89	No	Yes	0	7	9
45	R:R:F107	R:R:L184	67.4024	6.09	Yes	No	0	6	8
46	R:R:L184	R:R:L230	66.2572	2.77	No	Yes	0	8	5
47	R:R:F225	R:R:L230	51.9417	4.87	No	Yes	0	8	5
48	R:R:F225	R:R:L191	49.7762	18.27	No	No	0	8	8
49	R:R:L191	R:R:S114	11.8272	4.5	No	No	0	8	8
50	R:R:L191	R:R:S117	39.1775	4.5	No	No	0	8	9
51	R:R:S117	R:R:S195	34.3363	3.26	No	No	0	9	8
52	R:R:I218	R:R:S195	25.7991	4.64	Yes	No	0	8	8
53	R:R:E119	R:R:L122	15.6377	3.98	No	No	0	9	6
54	R:R:L122	R:R:W126	13.9719	2.28	No	No	0	6	6
55	R:R:L125	R:R:W126	11.9417	6.83	No	No	0	7	6
56	R:R:I218	R:R:L199	17.4701	8.56	Yes	No	0	8	5
57	R:R:I271	R:R:Y272	10.911	13.3	Yes	Yes	1	8	9
58	R:R:L230	R:R:P231	11.7959	1.64	Yes	No	0	5	9
59	R:R:G41	R:R:S266	11.4211	1.86	Yes	No	0	9	7
60	L:L:R17	R:R:F236	11.3587	4.28	Yes	Yes	4	0	4
61	R:R:D72	R:R:L76	16.3352	5.43	Yes	Yes	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F15	R:R:F236	3.22	4	No	Yes	0	4	0	1
L:L:R17	R:R:L160	7.29	4	Yes	No	0	3	0	1
L:L:R17	R:R:F236	4.28	4	Yes	Yes	0	4	0	1
L:L:R17	R:R:L240	12.15	4	Yes	No	0	4	0	1
R:R:F236	R:R:Y99	3.09	4	Yes	Yes	4	3	1	2
R:R:C161	R:R:L160	3.17	0	No	No	4	3	2	1
R:R:D177	R:R:F237	13.14	0	No	Yes	4	5	2	2
R:R:D177	R:R:L240	2.71	0	No	No	4	4	2	1
R:R:F236	R:R:F237	16.08	4	Yes	Yes	4	5	1	2
R:R:F236	R:R:L240	9.74	4	Yes	No	4	4	1	1
L:L:R14	R:R:W241	2	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JGB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	203
Number of Links	219
Number of Hubs	21
Number of Links mediated by Hubs	84
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	18878
Length Of Smallest Path	3
Average Path Length	12.8719
Length of Longest Path	31
Minimum Path Strength	1.38
Average Path Strength	5.52758
Maximum Path Strength	14.61
Minimum Path Correlation	0.7
Average Path Correlation	0.908617
Maximum Path Correlation	0.98
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.4331
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.7521
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Conorfamide-Tx2
UniProt	P0DM27
Sequence	>8JGB_nogp_Chain_L R F V R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8JGB_nogp_Chain_R L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8DWC	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWC (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.87	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	ML382	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.71	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	ML382		2.71	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWH	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWH (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3.25	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8HJ5	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-05-31	doi.org/10.1371/journal.pbio.3001975
	8HJ5 (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3	2023-05-31	doi.org/10.1371/journal.pbio.3001975
	8JGB	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/β1/γ2	2.84	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGB (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-		2.84	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGF	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGF (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.7	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/β1/γ2	3	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		3	2024-01-10	doi.org/10.1038/s41467-023-40705-z

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.