psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:K17	A:A:V12	4.55	No	No	0	4	1
2	A:A:D16	A:A:S13	10.31	No	No	0	4	7
3	A:A:E21	A:A:M25	4.06	No	No	0	3	4
4	A:A:R22	B:B:H91	3.39	No	Yes	0	4	5
5	A:A:D27	A:A:S23	4.42	Yes	No	2	6	7
6	A:A:S23	B:B:N88	4.47	No	Yes	0	7	7
7	A:A:S23	B:B:K89	4.59	No	Yes	2	7	9
8	A:A:I26	B:B:K89	5.82	No	Yes	0	9	9
9	A:A:I26	B:B:A92	3.25	No	No	0	9	6
10	A:A:D27	B:B:K89	11.06	Yes	Yes	2	6	9
11	A:A:L30	B:B:K89	4.23	No	Yes	0	5	9
12	A:A:D33	B:B:K78	8.3	No	No	0	5	8
13	A:A:E35	A:A:R38	8.14	No	No	13	4	4
14	A:A:E35	R:R:T136	7.06	No	No	13	4	4
15	A:A:K36	A:A:R39	3.71	No	No	0	2	5
16	A:A:R38	R:R:T136	5.17	No	No	13	4	4
17	A:A:N218	A:A:T40	5.85	No	No	0	4	7
18	A:A:F219	A:A:L41	8.53	Yes	No	0	8	6
19	A:A:L41	A:A:T242	7.37	No	No	0	6	8
20	A:A:F222	A:A:R42	3.21	Yes	No	1	7	9
21	A:A:D240	A:A:R42	10.72	No	No	0	6	9
22	A:A:R42	B:B:W99	4	No	Yes	1	9	9
23	A:A:I245	A:A:L43	7.14	No	No	0	7	7
24	A:A:F238	A:A:L44	12.18	Yes	No	0	9	9
25	A:A:K53	A:A:L45	5.64	No	Yes	0	9	8
26	A:A:L45	A:A:M221	8.48	Yes	No	0	8	8
27	A:A:I245	A:A:L45	4.28	No	Yes	0	7	8
28	A:A:F246	A:A:L46	3.65	Yes	No	0	9	8
29	A:A:I276	A:A:L46	4.28	No	No	0	8	8
30	A:A:D49	A:A:N50	8.08	No	No	14	8	9
31	A:A:D49	A:A:R265	9.53	No	Yes	14	8	9
32	A:A:N50	A:A:R265	6.03	No	Yes	14	9	9
33	A:A:K53	A:A:S51	4.59	No	No	0	9	9
34	A:A:D223	A:A:K53	4.15	No	No	0	9	9
35	A:A:S54	A:A:T55	3.2	No	No	0	9	9
36	A:A:I56	A:A:V247	4.61	No	No	0	7	7
37	A:A:I56	A:A:N371	5.66	No	Yes	0	7	9
38	A:A:E209	A:A:I207	4.1	No	No	1	9	9
39	A:A:I207	B:B:W99	3.52	No	Yes	1	9	9
40	A:A:I207	B:B:L117	4.28	No	Yes	1	9	9
41	A:A:D223	A:A:F208	7.17	No	No	0	9	5
42	A:A:E209	A:A:H220	13.54	No	No	1	9	7
43	A:A:E209	A:A:F222	13.99	No	Yes	1	9	7
44	A:A:M221	A:A:T210	4.52	No	No	0	8	7
45	A:A:H220	A:A:K211	18.34	No	No	0	7	4
46	A:A:F212	A:A:F219	11.79	No	Yes	0	9	8
47	A:A:A372	A:A:F212	4.16	No	No	0	8	9
48	A:A:K216	A:A:Q213	9.49	No	No	0	4	3
49	A:A:N218	A:A:Q213	7.92	No	No	0	4	3
50	A:A:R373	A:A:V214	3.92	No	No	0	5	6
51	A:A:F376	A:A:V214	3.93	Yes	No	0	8	6
52	A:A:D215	A:A:F376	11.94	No	Yes	0	5	8
53	A:A:F376	A:A:V217	6.55	Yes	No	0	8	5
54	A:A:F219	A:A:F376	8.57	Yes	Yes	0	8	8
55	A:A:C379	A:A:F219	4.19	No	Yes	0	8	8
56	A:A:F222	A:A:H220	14.71	Yes	No	1	7	7
57	A:A:F222	B:B:W99	15.03	Yes	Yes	1	7	9
58	A:A:V224	A:A:W234	14.71	No	Yes	0	9	9
59	A:A:D272	A:A:R231	11.91	No	No	0	8	9
60	A:A:R231	A:A:S275	9.22	No	No	0	9	8
61	A:A:I276	A:A:R231	8.77	No	No	0	8	9
62	A:A:R232	B:B:C204	6.96	No	No	15	8	7
63	A:A:R232	B:B:D228	10.72	No	No	15	8	9
64	A:A:K233	A:A:Q236	9.49	Yes	No	0	9	8
65	A:A:K233	B:B:M188	4.32	Yes	No	0	9	8
66	A:A:K233	B:B:N230	4.2	Yes	No	0	9	9
67	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
68	A:A:F238	A:A:W234	5.01	Yes	Yes	0	9	9
69	A:A:W234	B:B:L117	3.42	Yes	Yes	1	9	9
70	A:A:W234	B:B:Y145	3.86	Yes	Yes	1	9	8
71	A:A:I235	A:A:N279	4.25	No	No	0	9	8
72	A:A:Q236	A:A:W281	12.05	No	Yes	0	8	5
73	A:A:C237	B:B:Y59	6.72	No	Yes	1	8	8
74	A:A:C237	B:B:Q75	3.05	No	Yes	1	8	9
75	A:A:C237	B:B:M101	3.24	No	No	0	8	9
76	A:A:F238	A:A:V241	3.93	Yes	No	0	9	9
77	A:A:F238	B:B:W99	18.04	Yes	Yes	0	9	9
78	A:A:N239	B:B:K57	6.99	No	Yes	1	8	9
79	A:A:N239	B:B:W332	5.65	No	Yes	1	8	9
80	A:A:D240	B:B:K57	6.91	No	Yes	0	6	9
81	A:A:I285	A:A:V241	3.07	No	No	0	7	9
82	A:A:C379	A:A:T242	5.07	No	No	0	8	8
83	A:A:A243	A:A:I288	3.25	No	No	0	8	9
84	A:A:I244	A:A:L282	4.28	No	No	0	8	9
85	A:A:I244	A:A:I285	4.42	No	No	0	8	7
86	A:A:I244	A:A:V287	3.07	No	No	0	8	6
87	A:A:D272	A:A:F246	9.55	No	Yes	0	8	9
88	A:A:F246	A:A:F273	5.36	Yes	No	0	9	9
89	A:A:F246	A:A:L289	3.65	Yes	No	0	9	9
90	A:A:N292	A:A:V247	4.43	Yes	No	0	9	7
91	A:A:L291	A:A:V248	4.47	No	No	0	8	7
92	A:A:D249	A:A:S251	8.83	No	No	0	8	9
93	A:A:D249	A:A:K293	8.3	No	No	0	8	9
94	A:A:L297	A:A:S250	6.01	No	No	0	8	6
95	A:A:L296	A:A:S251	7.51	No	No	0	6	9
96	A:A:K300	A:A:S251	6.12	No	No	0	9	9
97	A:A:D252	A:A:N264	5.39	No	No	0	8	9
98	A:A:D252	A:A:R265	4.76	No	Yes	0	8	9
99	A:A:L297	A:A:Y253	4.69	No	Yes	0	8	8
100	A:A:K300	A:A:Y253	8.36	No	Yes	0	9	8
101	A:A:I308	A:A:Y253	8.46	No	Yes	0	7	8
102	A:A:Y253	A:A:Y311	5.96	Yes	No	0	8	6
103	A:A:N264	A:A:Y311	10.47	No	No	0	9	6
104	A:A:E268	A:A:R265	4.65	No	Yes	0	9	9
105	A:A:F312	A:A:L266	6.09	No	No	0	8	8
106	A:A:N271	A:A:Q267	6.6	No	No	0	5	4
107	A:A:E344	A:A:L270	5.3	Yes	No	0	5	6
108	A:A:F345	A:A:L270	8.53	No	No	0	8	6
109	A:A:F273	A:A:V287	6.55	No	No	0	9	6
110	A:A:F273	A:A:F345	10.72	No	No	0	9	8
111	A:A:I348	A:A:K274	11.63	No	No	0	4	5
112	A:A:I276	A:A:L282	4.28	No	No	0	8	9
113	A:A:N278	A:A:W277	3.39	No	Yes	0	8	6
114	A:A:V287	A:A:W277	3.68	No	Yes	0	6	6
115	A:A:S349	A:A:W277	7.41	Yes	Yes	0	7	6
116	A:A:G353	A:A:W277	4.22	No	Yes	0	4	6
117	A:A:H357	A:A:W277	29.62	No	Yes	0	7	6
118	A:A:N278	A:A:S352	5.96	No	No	0	8	5
119	A:A:L282	A:A:N279	6.87	No	No	0	9	8
120	A:A:R280	A:A:W281	7	No	Yes	0	5	5
121	A:A:W281	B:B:D290	6.7	Yes	Yes	1	5	6
122	A:A:W281	B:B:R314	12	Yes	Yes	1	5	8
123	A:A:W281	B:B:W332	4.69	Yes	Yes	1	5	9
124	A:A:G353	A:A:R283	4.5	No	Yes	0	4	3
125	A:A:D354	A:A:R283	10.72	No	Yes	0	3	3
126	A:A:R283	A:A:R356	4.26	Yes	No	0	3	2
127	A:A:H357	A:A:R283	4.51	No	Yes	0	7	3
128	A:A:I382	A:A:S286	6.19	No	No	0	6	8
129	A:A:F290	A:A:I288	3.77	Yes	No	0	9	9
130	A:A:D378	A:A:I288	8.4	No	No	0	7	9
131	A:A:F345	A:A:L289	3.65	No	No	0	8	9
132	A:A:C359	A:A:L289	3.17	No	No	0	5	9
133	A:A:F290	A:A:H362	4.53	Yes	No	0	9	9
134	A:A:F290	A:A:T364	5.19	Yes	Yes	0	9	9
135	A:A:F290	A:A:I375	5.02	Yes	No	0	9	9
136	A:A:F363	A:A:L291	8.53	No	No	0	5	8
137	A:A:K293	A:A:N292	6.99	No	Yes	0	9	9
138	A:A:N292	A:A:T364	4.39	Yes	Yes	0	9	9
139	A:A:K293	A:A:L296	4.23	No	No	0	9	6
140	A:A:K338	A:A:Q294	6.78	Yes	No	4	5	6
141	A:A:F363	A:A:Q294	11.71	No	No	4	5	6
142	A:A:D295	A:A:L296	6.79	No	No	0	9	6
143	A:A:C365	A:A:D295	3.11	No	No	0	8	9
144	A:A:V301	A:A:V334	3.21	No	Yes	0	7	4
145	A:A:D331	A:A:L302	5.43	No	No	0	4	2
146	A:A:L302	A:A:R333	8.5	No	No	0	2	5
147	A:A:E309	A:A:K307	9.45	No	No	0	4	6
148	A:A:D310	A:A:K307	6.91	No	No	0	3	6
149	A:A:F315	A:A:I308	15.07	Yes	No	0	6	7
150	A:A:E314	A:A:F312	7	Yes	No	4	6	8
151	A:A:F312	A:A:F340	5.36	No	Yes	4	8	7
152	A:A:E314	A:A:P313	4.72	Yes	No	0	6	6
153	A:A:E314	A:A:F340	8.16	Yes	Yes	4	6	7
154	A:A:E314	A:A:E344	5.07	Yes	Yes	4	6	5
155	A:A:F315	A:A:R336	16.03	Yes	No	0	6	5
156	A:A:F315	A:A:F340	15	Yes	Yes	0	6	7
157	A:A:P321	A:A:Y318	4.17	Yes	Yes	4	5	6
158	A:A:Y318	A:A:Y339	3.97	Yes	Yes	4	6	3
159	A:A:F340	A:A:Y318	8.25	Yes	Yes	4	7	6
160	A:A:K343	A:A:Y318	5.97	No	Yes	4	3	6
161	A:A:P321	A:A:T320	3.5	Yes	No	0	5	1
162	A:A:R336	A:A:T320	3.88	No	No	0	5	1
163	A:A:D323	A:A:P321	6.44	No	Yes	0	4	5
164	A:A:P321	A:A:Y339	6.95	Yes	Yes	4	5	3
165	A:A:A324	A:A:D323	3.09	No	No	0	3	4
166	A:A:A324	A:A:Y339	4	No	Yes	0	3	3
167	A:A:E327	A:A:P326	9.43	Yes	No	4	4	1
168	A:A:P326	A:A:Y339	4.17	No	Yes	4	1	3
169	A:A:E327	A:A:E330	8.88	Yes	Yes	4	4	3
170	A:A:E327	A:A:Y339	10.1	Yes	Yes	4	4	3
171	A:A:E330	A:A:V334	5.7	Yes	Yes	4	3	4
172	A:A:E330	A:A:T335	11.29	Yes	No	0	3	4
173	A:A:E330	A:A:K338	6.75	Yes	Yes	4	3	5
174	A:A:D331	A:A:P332	4.83	No	No	0	4	1
175	A:A:K338	A:A:V334	3.04	Yes	Yes	4	5	4
176	A:A:F363	A:A:K338	14.89	No	Yes	4	5	5
177	A:A:R342	A:A:Y339	15.43	No	Yes	0	4	3
178	A:A:F340	A:A:K343	4.96	Yes	No	4	7	3
179	A:A:E344	A:A:F340	9.33	Yes	Yes	4	5	7
180	A:A:P361	A:A:R342	5.76	No	No	0	5	4
181	A:A:D347	A:A:E344	5.2	No	Yes	0	4	5
182	A:A:S349	A:A:V346	3.23	Yes	No	0	7	4
183	A:A:D347	A:A:I348	5.6	No	No	0	4	4
184	A:A:S349	A:A:T350	3.2	Yes	No	0	7	4
185	A:A:C359	A:A:S349	3.44	No	Yes	0	5	7
186	A:A:G355	A:A:R356	4.5	No	No	0	2	2
187	A:A:I358	A:A:Y360	8.46	No	Yes	0	4	8
188	A:A:D378	A:A:Y360	12.64	No	Yes	0	7	8
189	A:A:D381	A:A:Y360	10.34	No	Yes	0	8	8
190	A:A:I382	A:A:Y360	4.84	No	Yes	0	6	8
191	A:A:H362	A:A:R374	7.9	No	Yes	0	9	4
192	A:A:D378	A:A:H362	8.82	No	No	0	7	9
193	A:A:N371	A:A:T364	10.24	Yes	Yes	9	9	9
194	A:A:R374	A:A:T364	3.88	Yes	Yes	9	4	9
195	A:A:C365	A:A:V367	3.42	No	No	0	8	9
196	A:A:D368	A:A:E370	3.9	Yes	No	9	9	4
197	A:A:D368	A:A:N371	5.39	Yes	Yes	9	9	9
198	A:A:D368	A:A:R374	4.76	Yes	Yes	9	9	4
199	A:A:E370	A:A:R373	9.3	No	No	0	4	5
200	A:A:E370	A:A:R374	16.28	No	Yes	9	4	4
201	A:A:N371	A:A:R374	4.82	Yes	Yes	9	9	4
202	A:A:N377	A:A:R373	4.82	No	No	0	4	5
203	A:A:F376	A:A:K380	4.96	Yes	No	0	8	7
204	A:A:I383	A:A:N387	4.25	No	Yes	6	8	8
205	A:A:I383	R:R:R131	6.26	No	No	6	8	6
206	A:A:L384	R:R:P127	4.93	No	No	0	6	9
207	A:A:M386	R:R:R131	11.17	No	No	0	4	6
208	A:A:N387	R:R:S123	7.45	Yes	No	6	8	8
209	A:A:N387	R:R:Y130	3.49	Yes	Yes	6	8	7
210	A:A:N387	R:R:R131	3.62	Yes	No	6	8	6
211	A:A:L388	A:A:L393	5.54	No	No	0	8	8
212	A:A:L388	A:A:V394	5.96	No	No	0	8	8
213	A:A:E390	A:A:Y391	12.35	No	Yes	6	4	4
214	A:A:E390	R:R:N59	7.89	No	No	0	4	8
215	A:A:E390	R:R:F61	3.5	No	Yes	6	4	7
216	A:A:Y391	R:R:F61	12.38	Yes	Yes	6	4	7
217	A:A:Y391	R:R:R120	6.17	Yes	No	0	4	9
218	A:A:Y391	R:R:S123	7.63	Yes	No	6	4	8
219	A:A:Y391	R:R:Y130	11.91	Yes	Yes	6	4	7
220	A:A:L393	R:R:L214	5.54	No	Yes	0	8	7
221	A:A:L393	R:R:T217	4.42	No	No	0	8	7
222	B:B:E3	B:B:Q6	28.03	No	No	0	5	1
223	B:B:D5	B:B:R8	16.68	No	No	0	1	3
224	B:B:I18	B:B:K15	7.27	Yes	No	0	7	6
225	B:B:K15	B:B:R19	4.95	No	No	0	6	4
226	B:B:N16	B:B:R19	9.64	No	No	0	1	4
227	B:B:A21	B:B:Q17	3.03	No	No	0	4	4
228	B:B:I18	B:B:R22	3.76	Yes	Yes	3	7	6
229	B:B:I18	G:G:A23	3.25	Yes	No	0	7	8
230	B:B:I18	G:G:R27	5.01	Yes	Yes	3	7	8
231	B:B:D258	B:B:R22	9.53	Yes	Yes	3	7	6
232	B:B:Q259	B:B:R22	8.18	No	Yes	0	6	6
233	B:B:R22	G:G:R27	4.26	Yes	Yes	3	6	8
234	B:B:A26	B:B:Q259	3.03	No	No	0	3	6
235	B:B:D27	G:G:K29	17.97	No	No	16	8	4
236	B:B:D27	G:G:S31	8.83	No	No	16	8	9
237	B:B:A28	B:B:I33	3.25	No	No	0	4	3
238	B:B:Q32	B:B:T29	9.92	No	No	0	1	3
239	B:B:L30	B:B:M262	11.31	No	No	0	5	4
240	B:B:I33	B:B:T34	3.04	No	No	0	3	5
241	B:B:I33	G:G:A34	4.87	No	No	0	3	6
242	B:B:I37	B:B:T34	4.56	No	No	0	2	5
243	B:B:T34	G:G:M38	13.55	No	No	0	5	4
244	B:B:I37	B:B:R283	5.01	No	Yes	0	2	9
245	B:B:I37	B:B:K301	11.63	No	Yes	0	2	5
246	B:B:G41	B:B:V40	3.68	No	Yes	0	1	3
247	B:B:I43	B:B:V40	3.07	No	Yes	0	3	3
248	B:B:R283	B:B:V40	5.23	Yes	Yes	17	9	3
249	B:B:D298	B:B:V40	4.38	No	Yes	17	9	3
250	B:B:V40	G:G:L51	4.47	Yes	No	0	3	6
251	B:B:I43	B:B:M45	4.37	No	No	0	3	4
252	B:B:Q44	B:B:R46	18.69	No	No	0	4	5
253	B:B:L308	B:B:M45	5.65	No	No	0	7	4
254	B:B:K337	B:B:T47	9.01	No	No	8	6	3
255	B:B:T47	B:B:W339	9.7	No	Yes	8	3	9
256	B:B:N340	B:B:R48	3.62	No	No	10	9	7
257	B:B:R48	G:G:F61	5.34	No	Yes	10	7	8
258	B:B:R49	B:B:T87	5.17	No	No	0	7	5
259	B:B:R49	G:G:F61	7.48	No	Yes	0	7	8
260	B:B:R52	B:B:T50	3.88	No	No	8	7	3
261	B:B:F335	B:B:T50	3.89	Yes	No	8	4	3
262	B:B:L51	B:B:W82	17.08	No	Yes	2	9	9
263	B:B:L51	B:B:T87	4.42	No	No	0	9	5
264	B:B:L336	B:B:L51	6.92	No	No	2	7	9
265	B:B:F335	B:B:R52	8.55	Yes	No	8	4	7
266	B:B:R52	R:R:M56	4.96	No	No	8	7	6
267	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
268	B:B:H54	B:B:I58	10.61	Yes	No	2	9	9
269	B:B:H54	B:B:S72	6.97	Yes	Yes	2	9	9
270	B:B:H54	B:B:S74	12.55	Yes	Yes	2	9	9
271	B:B:D76	B:B:H54	10.08	No	Yes	2	9	9
272	B:B:H54	B:B:I80	11.93	Yes	No	2	9	8
273	B:B:H54	B:B:W82	6.35	Yes	Yes	2	9	9
274	B:B:K57	B:B:Y59	11.94	Yes	Yes	1	9	8
275	B:B:K57	B:B:Q75	5.42	Yes	Yes	1	9	9
276	B:B:K57	B:B:W332	16.24	Yes	Yes	1	9	9
277	B:B:I58	B:B:S72	4.64	No	Yes	2	9	9
278	B:B:I58	B:B:S74	3.1	No	Yes	2	9	9
279	B:B:Q75	B:B:Y59	12.4	Yes	Yes	1	9	8
280	B:B:W332	B:B:Y59	10.61	Yes	Yes	1	9	8
281	B:B:A60	B:B:C103	3.61	No	No	0	7	8
282	B:B:M61	B:B:W63	5.82	Yes	Yes	2	6	7
283	B:B:L70	B:B:M61	4.24	No	Yes	2	5	6
284	B:B:C317	B:B:M61	4.86	No	Yes	0	7	6
285	B:B:A328	B:B:M61	3.22	No	Yes	2	5	6
286	B:B:H62	B:B:Y105	4.36	No	Yes	0	6	6
287	B:B:H62	B:B:R150	16.93	No	No	0	6	6
288	B:B:L70	B:B:W63	11.39	No	Yes	2	5	7
289	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
290	B:B:T321	B:B:W63	10.92	No	Yes	2	7	7
291	B:B:A328	B:B:W63	5.19	No	Yes	2	5	7
292	B:B:I338	B:B:W63	3.52	No	Yes	0	5	7
293	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
294	B:B:D66	B:B:R68	3.57	No	No	0	8	5
295	B:B:D66	B:B:L69	5.43	No	No	0	8	5
296	B:B:S67	B:B:T321	7.99	No	No	2	5	7
297	B:B:D323	B:B:S67	10.31	No	No	2	7	5
298	B:B:D83	B:B:R68	16.68	No	No	0	8	5
299	B:B:R68	B:B:Y85	16.46	No	No	0	5	4
300	B:B:D83	B:B:L69	4.07	No	No	0	8	5
301	B:B:L69	B:B:Y105	3.52	No	Yes	0	5	6
302	B:B:L70	B:B:W82	6.83	No	Yes	2	5	9
303	B:B:I81	B:B:V71	4.61	No	Yes	0	7	8
304	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
305	B:B:V71	B:B:Y105	3.79	Yes	Yes	0	8	6
306	B:B:V112	B:B:V71	3.21	No	Yes	0	8	8
307	B:B:S72	B:B:W82	4.94	Yes	Yes	2	9	9
308	B:B:L336	B:B:S72	7.51	No	Yes	2	7	9
309	B:B:A73	B:B:C103	3.61	No	No	0	9	8
310	B:B:D76	B:B:S74	10.31	No	Yes	2	9	9
311	B:B:Q75	B:B:W99	5.48	Yes	Yes	1	9	9
312	B:B:I93	B:B:L79	4.28	Yes	No	0	7	7
313	B:B:L79	B:B:L95	6.92	No	No	0	7	8
314	B:B:C114	B:B:L79	4.76	No	No	0	8	7
315	B:B:I80	B:B:W82	21.14	No	Yes	2	8	9
316	B:B:I80	B:B:K89	7.27	No	Yes	2	8	9
317	B:B:H91	B:B:I81	3.98	Yes	No	0	5	7
318	B:B:K89	B:B:W82	8.12	Yes	Yes	2	9	9
319	B:B:L336	B:B:W82	4.56	No	Yes	2	7	9
320	B:B:D83	B:B:T86	7.23	No	No	0	8	6
321	B:B:S84	G:G:F61	5.28	No	Yes	0	5	8
322	B:B:Y85	G:G:P60	11.13	No	Yes	10	4	9
323	B:B:Y85	G:G:F61	4.13	No	Yes	10	4	8
324	B:B:N88	B:B:T86	7.31	Yes	No	0	7	6
325	B:B:H91	B:B:V90	5.54	Yes	No	0	5	5
326	B:B:H91	B:B:V133	4.15	Yes	No	0	5	4
327	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
328	B:B:I93	B:B:Y124	10.88	Yes	Yes	0	7	6
329	B:B:I93	B:B:V133	4.61	Yes	No	0	7	4
330	B:B:L95	B:B:Y124	4.69	No	Yes	0	8	6
331	B:B:E138	B:B:R96	9.3	No	No	0	6	6
332	B:B:D118	B:B:S97	8.83	No	No	0	9	8
333	B:B:S98	B:B:W99	7.41	No	Yes	0	8	9
334	B:B:L117	B:B:W99	3.42	Yes	Yes	1	9	9
335	B:B:C114	B:B:V100	5.12	No	No	0	8	9
336	B:B:G116	B:B:M101	3.49	No	No	0	9	9
337	B:B:M101	B:B:Y145	5.99	No	Yes	0	9	8
338	B:B:C149	B:B:T102	5.07	No	No	0	8	8
339	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
340	B:B:L126	B:B:Y105	3.52	No	Yes	0	5	6
341	B:B:A106	B:B:F151	9.71	No	Yes	0	6	9
342	B:B:N110	B:B:S108	5.96	No	No	0	4	6
343	B:B:D154	B:B:S108	10.31	No	No	0	6	6
344	B:B:N110	B:B:Y111	3.49	No	Yes	0	4	4
345	B:B:K127	B:B:N110	15.39	No	No	0	4	4
346	B:B:I123	B:B:Y111	3.63	Yes	Yes	0	6	4
347	B:B:N125	B:B:Y111	13.96	No	Yes	0	4	4
348	B:B:D154	B:B:Y111	10.34	No	Yes	0	6	4
349	B:B:L126	B:B:V112	5.96	No	No	0	5	8
350	B:B:C114	B:B:G115	3.92	No	No	0	8	9
351	B:B:G115	B:B:L146	3.42	No	Yes	0	9	7
352	B:B:L117	B:B:Y145	4.69	Yes	Yes	1	9	8
353	B:B:D118	B:B:I120	4.2	No	No	0	9	6
354	B:B:G144	B:B:N119	3.39	No	No	0	8	9
355	B:B:E138	B:B:I120	9.56	No	No	0	6	6
356	B:B:C121	B:B:L146	3.17	No	Yes	0	8	7
357	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
358	B:B:E138	B:B:S122	4.31	No	No	0	6	8
359	B:B:I123	B:B:L139	7.14	Yes	No	0	6	9
360	B:B:I123	B:B:I157	4.42	Yes	Yes	0	6	7
361	B:B:I123	B:B:I171	5.89	Yes	No	0	6	6
362	B:B:V135	B:B:Y124	7.57	No	Yes	0	4	6
363	B:B:N125	B:B:R134	7.23	No	No	0	4	3
364	B:B:E130	B:B:R129	3.49	No	No	0	3	3
365	B:B:E130	B:B:N132	5.26	No	No	0	3	3
366	B:B:L139	B:B:W169	10.25	No	Yes	0	9	8
367	B:B:H142	B:B:T159	4.11	Yes	Yes	1	9	9
368	B:B:H142	B:B:S161	16.74	Yes	No	1	9	9
369	B:B:D163	B:B:H142	8.82	Yes	Yes	1	9	9
370	B:B:H142	B:B:W169	3.17	Yes	Yes	1	9	8
371	B:B:D163	B:B:T143	5.78	Yes	No	0	9	5
372	B:B:S147	B:B:Y145	5.09	No	Yes	1	9	8
373	B:B:G162	B:B:Y145	4.35	Yes	Yes	1	9	8
374	B:B:D186	B:B:Y145	10.34	No	Yes	1	9	8
375	B:B:M188	B:B:Y145	7.18	No	Yes	1	8	8
376	B:B:C149	B:B:L146	3.17	No	Yes	1	8	7
377	B:B:L146	B:B:T159	5.9	Yes	Yes	1	7	9
378	B:B:M188	B:B:S147	6.13	No	No	1	8	9
379	B:B:C148	B:B:R150	4.18	No	No	0	6	6
380	B:B:C148	B:B:L190	3.17	No	No	0	6	5
381	B:B:C149	B:B:T159	3.38	No	Yes	1	8	9
382	B:B:F151	B:B:I157	7.54	Yes	Yes	0	9	7
383	B:B:L152	B:B:Q156	3.99	Yes	No	0	3	5
384	B:B:L152	B:B:V158	4.47	Yes	No	0	3	5
385	B:B:L152	B:B:L192	6.92	Yes	No	0	3	5
386	B:B:L152	B:B:T196	5.9	Yes	No	0	3	1
387	B:B:D170	B:B:N155	12.12	No	No	18	9	3
388	B:B:E172	B:B:N155	14.46	No	No	18	6	3
389	B:B:L168	B:B:Q156	5.32	No	No	0	6	5
390	B:B:I157	B:B:T159	3.04	Yes	Yes	1	7	9
391	B:B:I157	B:B:W169	3.52	Yes	Yes	1	7	8
392	B:B:L168	B:B:V158	4.47	No	No	0	6	5
393	B:B:F199	B:B:V158	3.93	Yes	No	0	9	5
394	B:B:T159	B:B:W169	8.49	Yes	Yes	1	9	8
395	B:B:C166	B:B:S160	3.44	No	No	5	8	6
396	B:B:S160	B:B:V187	6.46	No	Yes	5	6	9
397	B:B:L190	B:B:S160	6.01	No	No	0	5	6
398	B:B:G162	B:B:S161	3.71	Yes	No	1	9	9
399	B:B:D163	B:B:S161	8.83	Yes	No	1	9	9
400	B:B:D186	B:B:G162	5.03	No	Yes	1	9	9
401	B:B:D163	B:B:T165	11.56	Yes	No	0	9	7
402	B:B:T165	B:B:T179	4.71	No	No	0	7	4
403	B:B:C166	B:B:V187	5.12	No	Yes	5	8	9
404	B:B:A167	B:B:W169	5.19	No	Yes	1	4	8
405	B:B:A167	B:B:Q176	4.55	No	Yes	1	4	4
406	B:B:L168	B:B:T177	4.42	No	No	0	6	4
407	B:B:Q176	B:B:W169	15.33	Yes	Yes	1	4	8
408	B:B:D170	B:B:E172	5.2	No	No	18	9	6
409	B:B:D170	B:B:T173	14.45	No	No	0	9	5
410	B:B:G174	B:B:T173	3.64	No	No	0	4	5
411	B:B:Q175	B:B:T173	4.25	No	No	0	4	5
412	B:B:Q176	B:B:T179	5.67	Yes	No	0	4	4
413	B:B:T177	B:B:T178	3.14	No	No	0	4	4
414	B:B:F180	B:B:T178	7.78	Yes	No	0	7	4
415	B:B:F180	B:B:F199	11.79	Yes	Yes	5	7	9
416	B:B:F180	B:B:W211	13.03	Yes	Yes	5	7	8
417	B:B:T181	G:G:K14	4.5	No	No	0	2	4
418	B:B:H183	B:B:V187	4.15	Yes	Yes	5	9	9
419	B:B:H183	B:B:S201	5.58	Yes	No	5	9	9
420	B:B:A203	B:B:H183	5.85	No	Yes	5	8	9
421	B:B:D205	B:B:H183	7.56	Yes	Yes	5	9	9
422	B:B:H183	B:B:S207	6.97	Yes	No	5	9	5
423	B:B:H183	B:B:K209	13.1	Yes	Yes	5	9	6
424	B:B:H183	B:B:W211	4.23	Yes	Yes	5	9	8
425	B:B:D205	B:B:T184	7.23	Yes	No	0	9	3
426	B:B:S201	B:B:V187	3.23	No	Yes	5	9	9
427	B:B:I232	B:B:S189	6.19	Yes	No	0	8	7
428	B:B:F234	B:B:S191	7.93	No	No	0	5	8
429	B:B:A193	B:B:D195	4.63	No	No	0	4	5
430	B:B:A193	B:B:F234	4.16	No	No	0	4	5
431	B:B:L198	B:B:R197	4.86	Yes	Yes	11	3	5
432	B:B:D212	B:B:R197	14.29	Yes	Yes	11	9	5
433	B:B:E215	B:B:R197	3.49	No	Yes	11	3	5
434	B:B:R197	B:B:R219	4.26	Yes	Yes	11	5	5
435	B:B:D212	B:B:L198	4.07	Yes	Yes	11	9	3
436	B:B:L198	B:B:R219	3.64	Yes	Yes	11	3	5
437	B:B:F199	B:B:W211	15.03	Yes	Yes	5	9	8
438	B:B:L210	B:B:V200	4.47	No	No	0	5	6
439	B:B:I232	B:B:V200	6.14	Yes	No	0	8	6
440	B:B:F234	B:B:V200	10.49	No	No	0	5	6
441	B:B:S201	B:B:W211	7.41	No	Yes	5	9	8
442	B:B:G202	B:B:I229	5.29	No	No	0	6	7
443	B:B:A203	B:B:D205	3.09	No	Yes	5	8	9
444	B:B:C204	B:B:D228	12.45	No	No	15	7	9
445	B:B:D205	B:B:S207	10.31	Yes	No	5	9	5
446	B:B:K209	B:B:W211	6.96	Yes	Yes	5	6	8
447	B:B:C218	B:B:K209	9.7	No	Yes	5	5	6
448	B:B:K209	B:B:T221	15.02	Yes	No	0	6	7
449	B:B:L210	B:B:L255	4.15	No	No	0	5	6
450	B:B:C218	B:B:W211	7.84	No	Yes	5	5	8
451	B:B:D212	B:B:E215	19.49	Yes	No	11	9	3
452	B:B:D212	B:B:R219	4.76	Yes	Yes	11	9	5
453	B:B:E215	B:B:R219	3.49	No	Yes	11	3	5
454	B:B:C218	G:G:Q18	3.05	No	No	0	5	9
455	B:B:F222	B:B:Q220	7.03	Yes	No	3	8	7
456	B:B:D258	B:B:Q220	14.36	Yes	No	3	7	7
457	B:B:Q220	G:G:I25	4.12	No	Yes	3	7	2
458	B:B:T221	G:G:E22	8.47	No	No	0	7	9
459	B:B:F222	B:B:F241	8.57	Yes	Yes	3	8	6
460	B:B:F222	B:B:F253	8.57	Yes	Yes	3	8	6
461	B:B:D258	B:B:F222	5.97	Yes	Yes	3	7	8
462	B:B:H225	B:B:I229	3.98	Yes	No	0	9	7
463	B:B:H225	B:B:T243	8.21	Yes	No	0	9	8
464	B:B:H225	B:B:S245	8.37	Yes	No	3	9	9
465	B:B:D247	B:B:H225	8.82	Yes	Yes	3	9	9
466	B:B:H225	B:B:T249	5.48	Yes	Yes	3	9	6
467	B:B:H225	B:B:R251	13.54	Yes	Yes	3	9	8
468	B:B:D247	B:B:E226	12.99	Yes	No	0	9	3
469	B:B:D246	B:B:N230	12.12	No	No	0	9	9
470	B:B:F241	B:B:I232	6.28	Yes	Yes	0	6	8
471	B:B:I232	B:B:T243	3.04	Yes	No	0	8	8
472	B:B:F235	B:B:P236	10.11	Yes	Yes	1	6	7
473	B:B:F235	B:B:F278	7.5	Yes	Yes	1	6	7
474	B:B:F235	B:B:G282	4.52	Yes	No	1	6	9
475	B:B:F235	G:G:Y40	6.19	Yes	No	1	6	6
476	B:B:F278	B:B:P236	5.78	Yes	Yes	1	7	7
477	B:B:G282	B:B:P236	4.06	No	Yes	1	9	7
478	B:B:P236	G:G:Y40	6.95	Yes	No	1	7	6
479	B:B:N237	B:B:N239	8.17	No	No	0	5	2
480	B:B:N239	B:B:R256	6.03	No	No	0	2	9
481	B:B:F241	B:B:F253	10.72	Yes	Yes	3	6	6
482	B:B:A242	B:B:L285	3.15	No	Yes	0	4	6
483	B:B:F253	B:B:T243	7.78	Yes	No	0	6	8
484	B:B:G244	B:B:I273	5.29	No	No	0	5	6
485	B:B:D247	B:B:S245	7.36	Yes	No	3	9	9
486	B:B:D247	B:B:T249	14.45	Yes	Yes	3	9	6
487	B:B:R251	B:B:T249	5.17	Yes	Yes	3	8	6
488	B:B:T249	B:B:T263	3.14	Yes	No	3	6	1
489	B:B:S265	B:B:T249	4.8	No	Yes	0	2	6
490	B:B:C250	B:B:Y264	4.03	No	Yes	1	8	5
491	B:B:C250	B:B:I273	6.55	No	No	0	8	6
492	B:B:C250	B:B:L285	3.17	No	Yes	1	8	6
493	B:B:F253	B:B:R251	4.28	Yes	Yes	3	6	8
494	B:B:E260	B:B:R251	17.45	Yes	Yes	3	6	8
495	B:B:R251	B:B:T263	11.64	Yes	No	3	8	1
496	B:B:L252	B:B:L261	4.15	No	No	0	7	5
497	B:B:L252	B:B:Y264	5.86	No	Yes	0	7	5
498	B:B:E260	B:B:F253	5.83	Yes	Yes	3	6	6
499	B:B:A257	B:B:D254	4.63	No	No	0	7	9
500	B:B:D254	B:B:L261	4.07	No	No	0	9	5
501	B:B:D254	G:G:A33	3.09	No	No	0	9	7
502	B:B:R256	G:G:I28	8.77	No	No	0	9	4
503	B:B:R256	G:G:D36	7.15	No	No	0	9	5
504	B:B:A257	B:B:Q259	3.03	No	No	0	7	6
505	B:B:D258	G:G:I25	4.2	Yes	Yes	3	7	2
506	B:B:D258	G:G:R27	10.72	Yes	Yes	3	7	8
507	B:B:E260	B:B:T263	8.47	Yes	No	3	6	1
508	B:B:L261	G:G:V30	4.47	No	No	0	5	8
509	B:B:M262	B:B:Y264	9.58	No	Yes	0	4	5
510	B:B:A302	B:B:M262	4.83	No	No	0	2	4
511	B:B:L285	B:B:Y264	3.52	Yes	Yes	1	6	5
512	B:B:W297	B:B:Y264	7.72	Yes	Yes	1	8	5
513	B:B:H266	B:B:N268	11.48	No	No	0	4	4
514	B:B:H266	B:B:I269	3.98	No	No	0	4	4
515	B:B:I269	B:B:Y289	4.84	No	Yes	0	4	7
516	B:B:C271	B:B:Y289	4.03	No	Yes	1	5	7
517	B:B:C271	B:B:D290	4.67	No	Yes	1	5	6
518	B:B:C271	B:B:D291	6.22	No	No	1	5	8
519	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
520	B:B:I273	B:B:Y289	8.46	No	Yes	0	6	7
521	B:B:S275	B:B:T274	3.2	No	No	0	8	8
522	B:B:R314	B:B:T274	5.17	Yes	No	0	8	8
523	B:B:L318	B:B:S275	6.01	Yes	No	0	6	8
524	B:B:L285	B:B:V276	4.47	Yes	No	0	6	6
525	B:B:L318	B:B:S277	4.5	Yes	Yes	0	6	5
526	B:B:S277	B:B:V320	3.23	Yes	No	0	5	7
527	B:B:F278	B:B:L285	9.74	Yes	Yes	1	7	6
528	B:B:S279	G:G:L50	4.5	No	No	0	9	9
529	B:B:K280	G:G:E47	5.4	No	No	0	1	3
530	B:B:S281	G:G:D48	11.78	No	No	0	9	9
531	B:B:D298	B:B:R283	9.53	No	Yes	17	9	9
532	B:B:R283	G:G:C41	4.18	Yes	No	0	9	7
533	B:B:L284	B:B:V296	5.96	No	No	0	5	5
534	B:B:L285	B:B:W297	3.42	Yes	Yes	1	6	8
535	B:B:C294	B:B:L286	3.17	No	No	19	5	7
536	B:B:L286	B:B:L318	6.92	No	Yes	19	7	6
537	B:B:L286	B:B:V327	4.47	No	No	0	7	6
538	B:B:A287	B:B:Y289	5.34	No	Yes	0	6	7
539	B:B:D291	B:B:Y289	4.6	No	Yes	1	8	7
540	B:B:N295	B:B:Y289	15.12	No	Yes	1	6	7
541	B:B:W297	B:B:Y289	5.79	Yes	Yes	1	8	7
542	B:B:D290	B:B:R314	7.15	Yes	Yes	1	6	8
543	B:B:D291	B:B:N293	13.46	No	No	0	8	5
544	B:B:N293	B:B:V307	5.91	No	No	0	5	3
545	B:B:C294	B:B:L308	6.35	No	No	0	5	7
546	B:B:C294	B:B:L318	3.17	No	Yes	19	5	6
547	B:B:N295	B:B:W297	7.91	No	Yes	1	6	8
548	B:B:N295	B:B:R304	4.82	No	No	1	6	5
549	B:B:G306	B:B:V296	3.68	No	No	0	4	5
550	B:B:R304	B:B:W297	4	No	Yes	1	5	8
551	B:B:D298	B:B:K301	8.3	No	Yes	0	9	5
552	B:B:L300	G:G:C41	3.17	No	No	0	6	7
553	B:B:R304	B:B:V307	3.92	No	No	0	5	3
554	B:B:L308	B:B:W339	17.08	No	Yes	0	7	9
555	B:B:H311	B:B:T329	6.85	Yes	No	0	9	8
556	B:B:H311	B:B:S331	16.74	Yes	No	8	9	9
557	B:B:D333	B:B:H311	10.08	No	Yes	8	9	9
558	B:B:H311	B:B:K337	6.55	Yes	No	8	9	6
559	B:B:D312	R:R:R57	7.15	No	No	0	5	6
560	B:B:N313	B:B:W332	6.78	No	Yes	0	7	9
561	B:B:N313	R:R:R57	3.62	No	No	0	7	6
562	B:B:R314	B:B:W332	29.99	Yes	Yes	1	8	9
563	B:B:T329	B:B:V315	3.17	No	No	0	8	7
564	B:B:S331	B:B:V315	3.23	No	No	0	9	7
565	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
566	B:B:D323	B:B:T321	7.23	No	No	2	7	7
567	B:B:D323	B:B:M325	9.7	No	No	0	7	5
568	B:B:M325	G:G:P49	6.71	No	No	0	5	7
569	B:B:M325	G:G:P60	5.03	No	Yes	0	5	9
570	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
571	B:B:V327	G:G:L50	4.47	No	No	0	6	9
572	B:B:T329	B:B:W339	6.06	No	Yes	0	8	9
573	B:B:D333	B:B:S331	5.89	No	No	8	9	9
574	B:B:D333	B:B:F335	4.78	No	Yes	8	9	4
575	B:B:F335	R:R:M56	6.22	Yes	No	8	4	6
576	B:B:K337	B:B:W339	5.8	No	Yes	8	6	9
577	B:B:I338	G:G:F61	6.28	No	Yes	0	5	8
578	B:B:N340	G:G:F61	3.62	No	Yes	10	9	8
579	G:G:R13	G:G:V16	6.54	No	No	20	6	7
580	G:G:E17	G:G:R13	24.42	No	No	0	6	6
581	G:G:K20	G:G:R13	7.43	Yes	No	20	6	6
582	G:G:K20	G:G:V16	3.04	Yes	No	20	6	7
583	G:G:E22	G:G:Q18	3.82	No	No	0	9	9
584	G:G:I25	G:G:R27	8.77	Yes	Yes	3	2	8
585	G:G:K29	G:G:S31	4.59	No	No	16	4	9
586	G:G:H44	G:G:Y40	14.16	No	No	0	6	6
587	G:G:E47	G:G:H44	3.69	No	No	0	3	6
588	G:G:E47	G:G:K46	12.15	No	No	0	3	1
589	G:G:D48	G:G:L51	13.57	No	No	0	9	6
590	G:G:P49	G:G:V54	3.53	No	Yes	0	7	6
591	G:G:L51	G:G:T52	4.42	No	No	0	6	4
592	G:G:P55	G:G:V54	5.3	No	Yes	21	5	6
593	G:G:E58	G:G:V54	4.28	No	Yes	21	5	6
594	G:G:N59	G:G:V54	8.87	No	Yes	0	9	6
595	G:G:P55	G:G:S57	3.56	No	No	0	5	6
596	G:G:E58	G:G:P55	6.29	No	No	21	5	5
597	G:G:N59	G:G:P60	4.89	No	Yes	0	9	9
598	G:G:F61	G:G:P60	7.22	Yes	Yes	10	8	9
599	R:R:C251	R:R:Q26	9.16	No	No	0	1	1
600	R:R:L30	R:R:S29	6.01	No	No	0	5	4
601	R:R:L255	R:R:L30	4.15	No	No	0	2	5
602	R:R:F259	R:R:L30	4.87	Yes	No	0	5	5
603	R:R:F259	R:R:L33	8.53	Yes	No	0	5	6
604	R:R:S83	R:R:T34	3.2	No	No	0	6	5
605	R:R:F259	R:R:T34	3.89	Yes	No	0	5	5
606	R:R:C35	R:R:L80	3.17	No	No	0	5	7
607	R:R:L39	R:R:L80	4.15	No	No	0	5	7
608	R:R:G41	R:R:S266	3.71	No	No	0	9	7
609	R:R:F73	R:R:L42	8.53	No	No	0	7	7
610	R:R:L42	R:R:L76	4.15	No	Yes	0	7	7
611	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
612	R:R:N45	R:R:P269	13.03	No	No	0	9	9
613	R:R:F274	R:R:V47	5.24	Yes	No	0	7	6
614	R:R:A69	R:R:V48	3.39	No	No	0	9	9
615	R:R:F273	R:R:V48	11.8	Yes	No	22	7	9
616	R:R:F274	R:R:V48	3.93	Yes	No	22	7	9
617	R:R:F273	R:R:L51	4.87	Yes	No	0	7	7
618	R:R:L52	R:R:L66	4.15	No	No	0	7	7
619	R:R:I63	R:R:R58	3.76	No	No	0	7	7
620	R:R:L66	R:R:R58	3.64	No	No	0	7	7
621	R:R:N59	R:R:S62	7.45	No	No	0	8	7
622	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
623	R:R:F61	R:R:I65	7.54	Yes	No	0	7	8
624	R:R:F61	R:R:V116	3.93	Yes	No	0	7	8
625	R:R:I63	R:R:S139	7.74	No	No	0	7	9
626	R:R:E119	R:R:Y64	16.83	No	Yes	0	9	7
627	R:R:S139	R:R:Y64	13.99	No	Yes	0	9	7
628	R:R:V142	R:R:Y64	5.05	No	Yes	0	6	7
629	R:R:C143	R:R:Y64	4.03	No	Yes	0	7	7
630	R:R:I65	R:R:Y272	4.84	No	Yes	0	8	9
631	R:R:F112	R:R:N67	4.83	Yes	No	12	7	9
632	R:R:C143	R:R:N67	7.87	No	No	12	7	9
633	R:R:N67	R:R:W147	4.52	No	Yes	12	9	9
634	R:R:D72	R:R:L68	8.14	Yes	No	0	9	9
635	R:R:F112	R:R:L68	6.09	Yes	No	0	7	9
636	R:R:L113	R:R:L68	4.15	Yes	No	0	8	9
637	R:R:D72	R:R:S265	11.78	Yes	No	0	9	9
638	R:R:D72	R:R:N268	6.73	Yes	Yes	0	9	9
639	R:R:F75	R:R:R79	9.62	Yes	Yes	0	6	6
640	R:R:F75	R:R:S105	3.96	Yes	No	0	6	8
641	R:R:F75	R:R:Y106	6.19	Yes	Yes	0	6	7
642	R:R:F75	R:R:S261	7.93	Yes	No	0	6	7
643	R:R:F75	R:R:S265	3.96	Yes	No	0	6	9
644	R:R:L76	R:R:S265	4.5	Yes	No	0	7	9
645	R:R:G78	R:R:S77	3.71	No	No	0	5	5
646	R:R:M102	R:R:R79	9.93	No	Yes	0	4	6
647	R:R:F232	R:R:R79	3.21	Yes	Yes	0	5	6
648	R:R:I258	R:R:R79	13.78	No	Yes	0	4	6
649	R:R:I81	R:R:L98	5.71	No	No	0	5	4
650	R:R:S95	R:R:Y82	3.82	No	No	0	7	3
651	R:R:L98	R:R:Y82	3.52	No	No	0	4	3
652	L:L:?1	R:R:Y82	3.07	Yes	No	0	0	3
653	R:R:I90	R:R:L85	17.13	No	No	0	5	4
654	R:R:F87	R:R:I88	3.77	No	No	0	4	3
655	R:R:I90	R:R:P91	8.47	No	No	0	5	7
656	R:R:H92	R:R:T93	5.48	No	No	0	1	2
657	R:R:I94	R:R:L98	4.28	No	No	0	5	4
658	L:L:?1	R:R:K96	9.84	Yes	No	0	0	5
659	R:R:P100	R:R:Y99	6.95	No	Yes	0	4	3
660	R:R:M103	R:R:Y99	13.17	No	Yes	0	2	3
661	R:R:E157	R:R:Y99	8.98	Yes	Yes	7	4	3
662	R:R:F236	R:R:Y99	7.22	No	Yes	0	4	3
663	L:L:?1	R:R:Y99	32.71	Yes	Yes	7	0	3
664	R:R:F104	R:R:W147	6.01	No	Yes	0	5	9
665	R:R:F104	R:R:S150	7.93	No	No	0	5	8
666	R:R:F107	R:R:Y106	6.19	Yes	Yes	0	6	7
667	R:R:L110	R:R:Y106	9.38	No	Yes	0	7	7
668	R:R:F232	R:R:Y106	7.22	Yes	Yes	0	5	7
669	R:R:F107	R:R:R153	10.69	Yes	Yes	7	6	4
670	R:R:F107	R:R:T180	3.89	Yes	No	7	6	5
671	R:R:F107	R:R:L184	7.31	Yes	No	0	6	8
672	R:R:F107	R:R:F237	4.29	Yes	Yes	7	6	5
673	R:R:A108	R:R:W147	5.19	No	Yes	0	7	9
674	R:R:A108	R:R:S150	3.42	No	No	0	7	8
675	R:R:F225	R:R:L110	6.09	Yes	No	0	8	7
676	R:R:L146	R:R:S111	7.51	No	No	0	7	6
677	R:R:C143	R:R:F112	5.59	No	Yes	12	7	7
678	R:R:F112	R:R:L146	4.87	Yes	No	0	7	7
679	R:R:F112	R:R:W147	7.02	Yes	Yes	12	7	9
680	R:R:F225	R:R:L113	6.09	Yes	Yes	0	8	8
681	R:R:L113	R:R:N268	5.49	Yes	Yes	23	8	9
682	R:R:L113	R:R:Y272	5.86	Yes	Yes	23	8	9
683	R:R:L187	R:R:S114	6.01	No	No	0	9	8
684	R:R:S114	R:R:V190	3.23	No	No	0	8	6
685	R:R:L191	R:R:S117	6.01	No	No	0	8	9
686	R:R:S117	R:R:S194	4.89	No	No	0	9	8
687	R:R:S194	R:R:T118	4.8	No	No	0	8	7
688	R:R:E119	R:R:Y130	12.35	No	Yes	6	9	7
689	R:R:E119	R:R:R134	9.3	No	Yes	6	9	9
690	R:R:R120	R:R:T221	9.06	No	No	0	9	8
691	R:R:C121	R:R:L125	3.17	No	No	0	8	7
692	R:R:C121	R:R:V197	3.42	No	No	0	8	4
693	R:R:S123	R:R:Y130	12.72	No	Yes	6	8	7
694	R:R:L198	R:R:V124	5.96	No	No	0	8	8
695	R:R:L125	R:R:W126	4.56	No	No	0	7	6
696	R:R:L125	R:R:R201	4.86	No	No	0	7	6
697	R:R:C132	R:R:I128	3.27	No	No	0	6	6
698	R:R:W129	R:R:Y130	5.79	No	Yes	0	5	7
699	R:R:R134	R:R:Y130	14.4	Yes	Yes	6	9	7
700	R:R:C132	R:R:H133	4.42	No	No	0	6	5
701	R:R:P135	R:R:R134	4.32	No	Yes	6	7	9
702	R:R:L138	R:R:R134	12.15	No	Yes	6	4	9
703	R:R:L138	R:R:P135	9.85	No	No	6	4	7
704	R:R:H137	R:R:T136	8.21	No	No	0	6	4
705	R:R:E157	R:R:R153	9.3	Yes	Yes	7	4	4
706	R:R:R153	R:R:T180	6.47	Yes	No	7	4	5
707	R:R:L156	R:R:L160	4.15	No	No	0	7	3
708	R:R:E157	R:R:F237	4.66	Yes	Yes	7	4	5
709	L:L:?1	R:R:E157	8.09	Yes	Yes	7	0	4
710	R:R:M159	R:R:W158	3.49	No	No	0	4	4
711	R:R:F163	R:R:W158	7.02	No	No	0	4	4
712	R:R:L164	R:R:W158	3.42	No	No	0	1	4
713	R:R:F165	R:R:L160	3.65	Yes	No	0	1	3
714	R:R:C161	R:R:C173	7.28	No	No	7	4	9
715	L:L:?1	R:R:C161	6.92	Yes	No	7	0	4
716	R:R:A168	R:R:F165	5.55	No	Yes	0	2	1
717	R:R:A171	R:R:D169	4.63	No	No	0	4	3
718	R:R:C173	R:R:D177	4.67	No	Yes	7	9	4
719	L:L:?1	R:R:C173	5.54	Yes	No	7	0	9
720	R:R:Q174	R:R:W241	3.29	No	Yes	0	3	3
721	R:R:D177	R:R:F237	3.58	Yes	Yes	7	4	5
722	R:R:D177	R:R:L240	8.14	Yes	No	7	4	4
723	L:L:?1	R:R:D177	8.28	Yes	Yes	7	0	4
724	R:R:F178	R:R:W241	6.01	No	Yes	0	3	3
725	R:R:F237	R:R:T180	11.67	Yes	No	7	5	5
726	R:R:L238	R:R:V181	5.96	No	No	0	5	5
727	R:R:L187	R:R:W183	4.56	No	No	0	9	6
728	R:R:F186	R:R:V190	3.93	No	No	0	5	6
729	R:R:F225	R:R:L191	8.53	Yes	No	0	8	8
730	R:R:C192	R:R:L226	4.76	No	No	0	5	6
731	R:R:I218	R:R:S195	3.1	No	No	0	8	8
732	R:R:S195	R:R:V222	3.23	No	No	0	8	8
733	R:R:I200	R:R:L196	4.28	No	No	0	5	4
734	R:R:L198	R:R:L214	4.15	No	Yes	0	8	7
735	R:R:I218	R:R:L199	5.71	No	No	0	8	5
736	R:R:I202	R:R:L214	5.71	No	Yes	0	6	7
737	R:R:L203	R:R:Y215	5.86	No	No	0	5	6
738	R:R:L211	R:R:Y215	7.03	No	No	0	6	6
739	R:R:R213	R:R:V275	3.92	No	No	0	7	8
740	R:R:I218	R:R:L214	5.71	No	Yes	0	8	7
741	R:R:I271	R:R:L220	4.28	Yes	No	0	8	6
742	R:R:T221	R:R:Y272	8.74	No	Yes	0	8	9
743	R:R:I271	R:R:V224	4.61	Yes	No	0	8	7
744	R:R:F225	R:R:L226	3.65	Yes	No	0	8	6
745	R:R:C228	R:R:L263	3.17	No	No	0	8	5
746	R:R:C228	R:R:N264	3.15	No	No	0	8	9
747	R:R:G229	R:R:N264	5.09	No	No	0	8	9
748	R:R:F232	R:R:F236	3.22	Yes	No	0	5	4
749	R:R:F232	R:R:S261	7.93	Yes	No	0	5	7
750	R:R:I234	R:R:L238	4.28	No	No	0	6	5
751	R:R:H254	R:R:Q235	7.42	No	No	0	1	3
752	R:R:Q235	R:R:S257	10.11	No	No	0	3	6
753	R:R:F236	R:R:F237	6.43	No	Yes	0	4	5
754	R:R:F239	R:R:I242	3.77	No	No	24	4	1
755	R:R:F239	R:R:V244	14.42	No	No	24	4	1
756	R:R:F239	R:R:L249	7.31	No	No	0	4	3
757	L:L:?1	R:R:L240	7.24	Yes	No	7	0	4
758	R:R:I242	R:R:W241	4.7	No	Yes	0	1	3
759	R:R:I242	R:R:V244	3.07	No	No	24	1	1
760	R:R:D245	R:R:E247	22.09	No	No	0	3	2
761	R:R:E247	R:R:R246	3.49	No	No	0	2	2
762	R:R:H252	R:R:V248	9.69	No	No	0	1	1
763	R:R:F250	R:R:H254	10.18	No	No	0	3	1
764	R:R:F250	R:R:L255	7.31	No	No	0	3	2
765	R:R:F259	R:R:L260	3.65	Yes	No	0	5	7
766	R:R:N264	R:R:N268	8.17	No	Yes	0	9	9
767	R:R:A267	R:R:I271	3.25	No	Yes	0	7	8
768	R:R:N268	R:R:Y272	3.49	Yes	Yes	23	9	9
769	R:R:I271	R:R:Y272	7.25	Yes	Yes	0	8	9
770	R:R:F273	R:R:F274	7.5	Yes	Yes	22	7	7
771	R:R:F274	R:R:S277	5.28	Yes	No	0	7	6
772	R:R:F278	R:R:S277	9.25	No	No	0	5	6
773	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
774	R:R:F107	R:R:W183	3.01	Yes	No	0	6	6
775	R:R:F112	R:R:G109	3.01	Yes	No	0	7	9
776	R:R:F165	R:R:W172	3.01	Yes	No	0	1	1
777	R:R:F237	R:R:G233	3.01	Yes	No	0	5	7
778	A:A:K58	A:A:T55	3	No	No	0	9	9
779	B:B:G174	B:B:R137	3	No	No	0	4	5
780	R:R:L76	R:R:S38	3	Yes	No	0	7	5
781	R:R:L74	R:R:S77	3	No	No	0	7	5
782	R:R:L74	R:R:S105	3	No	No	0	7	8
783	R:R:L76	R:R:S266	3	Yes	No	0	7	7
784	A:A:L45	A:A:V247	2.98	Yes	No	0	8	7
785	B:B:L284	B:B:V40	2.98	No	Yes	0	5	3
786	B:B:N125	B:B:S136	2.98	No	No	0	4	4
787	R:R:L28	R:R:V32	2.98	No	No	0	4	6
788	R:R:L33	R:R:V37	2.98	No	No	0	6	7
789	R:R:L263	R:R:V37	2.98	No	No	0	5	7
790	R:R:L226	R:R:V222	2.98	No	No	0	6	8
791	R:R:L260	R:R:V256	2.98	No	No	0	7	4
792	R:R:D169	R:R:S170	2.94	No	No	0	3	3
793	R:R:I155	R:R:M159	2.92	No	No	0	4	4
794	A:A:K380	R:R:I128	2.91	No	No	0	7	6
795	G:G:I28	G:G:K32	2.91	No	No	0	4	5
796	B:B:G288	B:B:Y289	2.9	No	Yes	0	7	7
797	B:B:D322	B:B:T65	2.89	No	No	0	1	1
798	R:R:E157	R:R:S176	2.87	Yes	No	0	4	3
799	R:R:Q235	R:R:V253	2.87	No	No	0	3	4
800	A:A:I383	A:A:L41	2.85	No	No	0	8	6
801	A:A:I341	A:A:L266	2.85	No	No	0	8	8
802	A:A:I341	A:A:L297	2.85	No	No	0	8	8
803	R:R:I81	R:R:L85	2.85	No	No	0	5	4
804	R:R:I155	R:R:L151	2.85	No	No	0	4	4
805	R:R:I234	R:R:L184	2.85	No	No	0	6	8
806	A:A:L30	B:B:K78	2.82	No	No	0	5	8
807	B:B:L14	G:G:K20	2.82	No	Yes	0	8	6
808	B:B:K15	G:G:L19	2.82	No	No	0	6	9
809	B:B:G310	B:B:W339	2.81	No	Yes	0	5	9
810	B:B:C25	G:G:R27	2.79	No	Yes	0	3	8
811	A:A:L384	A:A:L388	2.77	No	No	0	6	8
812	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
813	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
814	B:B:L198	B:B:L210	2.77	Yes	No	0	3	5
815	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
816	B:B:A240	B:B:F235	2.77	No	Yes	0	6	6
817	B:B:L252	G:G:L37	2.77	No	No	0	7	7
818	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
819	R:R:A71	R:R:F112	2.77	No	Yes	0	9	7
820	R:R:L219	R:R:L223	2.77	No	No	0	5	6
821	A:A:I358	A:A:Q385	2.74	No	No	0	4	5
822	R:R:A115	R:R:Y64	2.67	No	Yes	0	7	7
823	A:A:L270	A:A:Q267	2.66	No	No	0	6	4
824	B:B:D153	B:B:D154	2.66	No	No	0	5	6
825	B:B:E10	B:B:L7	2.65	No	No	0	8	8
826	B:B:F335	B:B:S334	2.64	Yes	No	0	4	4
827	R:R:F163	R:R:S166	2.64	No	No	0	4	1
828	A:A:F212	A:A:V57	2.62	No	No	0	9	7
829	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
830	A:A:R283	A:A:T284	2.59	Yes	No	0	3	4
831	A:A:K233	A:A:R232	2.48	Yes	No	0	9	8
832	R:R:F273	R:R:L52	2.44	Yes	No	0	7	7
833	R:R:F165	R:R:L164	2.44	Yes	No	0	1	1
834	R:R:F225	R:R:L230	2.44	Yes	No	0	8	5
835	B:B:L139	B:B:R137	2.43	No	No	0	9	5
836	R:R:L52	R:R:R55	2.43	No	No	0	7	6
837	B:B:F235	B:B:N237	2.42	Yes	No	0	6	5
838	B:B:F292	B:B:N313	2.42	No	No	0	4	7
839	B:B:N132	B:B:R134	2.41	No	No	0	3	3
840	A:A:Q385	A:A:R389	2.34	No	No	0	5	5
841	R:R:L199	R:R:Y215	2.34	No	No	0	5	6
842	R:R:L122	R:R:W126	2.28	No	No	0	6	6
843	R:R:L238	R:R:W241	2.28	No	Yes	0	5	3
844	A:A:R39	R:R:H133	2.26	No	No	0	5	5
845	R:R:D169	R:R:W172	2.23	No	No	0	3	1
846	B:B:R46	B:B:R48	2.13	No	No	0	5	7
847	B:B:G144	B:B:G162	2.11	No	Yes	0	8	9
848	B:B:G238	B:B:P194	2.03	No	No	0	7	4
849	B:B:G324	G:G:P49	2.03	No	No	0	9	7
850	R:R:G229	R:R:P231	2.03	No	No	0	8	9
851	B:B:C317	B:B:G330	1.96	No	No	0	7	5
852	R:R:C192	R:R:G193	1.96	No	No	0	5	4
853	A:A:A37	A:A:G34	1.95	No	No	0	3	5
854	B:B:A140	B:B:G141	1.95	No	No	0	5	5
855	B:B:A106	B:B:P107	1.87	No	No	0	6	6
856	B:B:A193	B:B:P194	1.87	No	No	0	4	4
857	A:A:G47	A:A:S51	1.86	No	No	0	9	9
858	B:B:G77	B:B:S98	1.86	No	No	0	8	8
859	B:B:G319	B:B:S277	1.86	No	Yes	0	5	5
860	R:R:G162	R:R:S166	1.86	No	No	0	2	1
861	R:R:G167	R:R:S166	1.86	No	No	0	1	1
862	A:A:G225	A:A:V224	1.84	No	No	0	9	9
863	R:R:G41	R:R:V40	1.84	No	No	0	9	6
864	R:R:G44	R:R:V47	1.84	No	No	0	8	6
865	A:A:G52	A:A:T55	1.82	No	No	0	9	9
866	B:B:G185	B:B:T164	1.82	No	No	0	5	6
867	B:B:G182	B:B:T181	1.82	No	No	0	6	2
868	R:R:G44	R:R:T43	1.82	No	No	0	8	5
869	R:R:C188	R:R:C192	1.82	No	No	0	6	5
870	B:B:P107	B:B:T65	1.75	No	No	0	6	1
871	G:G:P53	G:G:T52	1.75	No	No	0	8	4
872	B:B:G182	B:B:K209	1.74	No	Yes	0	6	6
873	B:B:C233	B:B:S277	1.72	No	Yes	0	3	5
874	R:R:C35	R:R:S83	1.72	No	No	0	5	6
875	R:R:C121	R:R:S194	1.72	No	No	0	8	8
876	A:A:G34	B:B:L55	1.71	No	No	0	5	6
877	B:B:A56	B:B:S74	1.71	No	Yes	0	7	9
878	R:R:A262	R:R:S38	1.71	No	No	0	6	5
879	R:R:G193	R:R:L196	1.71	No	No	0	4	4
880	A:A:G52	A:A:N292	1.7	No	Yes	0	9	9
881	A:A:G206	B:B:N119	1.7	No	No	0	8	9
882	A:A:A269	A:A:V248	1.7	No	No	0	9	7
883	A:A:A298	A:A:V334	1.7	No	Yes	0	4	4
884	A:A:N392	R:R:G276	1.7	No	No	0	7	8
885	B:B:A11	G:G:V16	1.7	No	No	0	5	7
886	B:B:A231	B:B:V276	1.7	No	No	0	5	6
887	B:B:A309	B:B:V307	1.7	No	No	0	3	3
888	B:B:D186	B:B:G185	1.68	No	No	0	9	5
889	A:A:E330	A:A:G329	1.64	Yes	No	0	3	7
890	B:B:G141	B:B:Q176	1.64	No	Yes	0	5	4
891	B:B:E260	B:B:G224	1.64	Yes	No	0	6	6
892	R:R:C204	R:R:I200	1.64	No	No	0	5	5
893	B:B:S227	B:B:S245	1.63	No	No	0	6	9
894	B:B:A248	B:B:I269	1.62	No	No	0	5	4
895	B:B:D38	B:B:P39	1.61	No	No	0	1	1
896	B:B:S207	B:B:T223	1.6	No	No	0	5	2
897	R:R:S86	R:R:T27	1.6	No	No	0	2	4
898	R:R:S83	R:R:T31	1.6	No	No	0	6	4
899	R:R:C228	R:R:L227	1.59	No	No	0	8	5
900	B:B:A11	G:G:L19	1.58	No	No	0	5	9
901	R:R:A69	R:R:L49	1.58	No	No	0	9	7
902	R:R:A70	R:R:L49	1.58	No	No	0	6	7
903	A:A:E327	A:A:P328	1.57	Yes	No	0	4	1
904	R:R:T27	R:R:T31	1.57	No	No	0	4	4
905	A:A:A19	B:B:N88	1.56	No	Yes	0	5	7
906	A:A:A20	B:B:N88	1.56	No	Yes	0	3	7
907	A:A:A48	A:A:D49	1.54	No	No	0	8	8
908	B:B:A28	B:B:D27	1.54	No	No	0	4	8
909	R:R:I185	R:R:V181	1.54	No	No	0	5	5
910	R:R:I185	R:R:V189	1.54	No	No	0	5	4
911	B:B:Q17	G:G:A23	1.52	No	No	0	4	8
912	B:B:A28	B:B:Q32	1.52	No	No	0	4	1
913	A:A:A19	A:A:E15	1.51	No	No	0	5	5
914	A:A:A316	A:A:E309	1.51	No	No	0	2	4
915	B:B:G306	B:B:R42	1.5	No	No	0	4	2
916	R:R:G53	R:R:R58	1.5	No	No	0	5	7
917	A:A:L302	A:A:V301	1.49	No	No	0	2	7
918	R:R:L74	R:R:V101	1.49	No	No	0	7	6
919	L:L:?1	R:R:G162	1.49	Yes	No	0	0	2
920	R:R:I94	R:R:I97	1.47	No	No	0	5	4
921	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
922	A:A:D368	A:A:T369	1.45	Yes	No	0	9	9
923	R:R:Q26	R:R:S29	1.44	No	No	0	1	4
924	R:R:I179	R:R:L156	1.43	No	No	0	5	7
925	A:A:E327	A:A:T325	1.41	Yes	No	0	4	2
926	A:A:K28	A:A:N29	1.4	No	No	0	4	4
927	B:B:K301	B:B:N35	1.4	Yes	No	0	5	1
928	G:G:K20	G:G:N24	1.4	Yes	No	0	6	1
929	G:G:D26	G:G:I25	1.4	No	Yes	0	1	2
930	A:A:A337	A:A:F315	1.39	No	Yes	0	8	6
931	R:R:A46	R:R:F73	1.39	No	No	0	6	7
932	A:A:D27	A:A:K24	1.38	Yes	No	0	6	4
933	B:B:D303	B:B:K301	1.38	No	Yes	0	2	5
934	R:R:L146	R:R:L149	1.38	No	No	0	7	6
935	R:R:L199	R:R:L219	1.38	No	No	0	5	5
936	R:R:H252	R:R:V253	1.38	No	No	0	1	4
937	B:B:M217	G:G:Q18	1.36	No	No	0	3	9
938	B:B:D20	B:B:N16	1.35	No	No	0	2	1
939	B:B:D267	B:B:N268	1.35	No	No	0	3	4
940	R:R:F104	R:R:S154	1.32	No	No	0	5	6
941	R:R:R153	R:R:S154	1.32	Yes	No	0	4	6
942	B:B:D5	B:B:Q9	1.31	No	No	0	1	3
943	B:B:E12	B:B:N16	1.31	No	No	0	4	1
944	R:R:H92	R:R:K96	1.31	No	No	0	1	5
945	A:A:D16	A:A:E15	1.3	No	No	0	4	5
946	B:B:R129	B:B:T128	1.29	No	No	0	3	3
947	B:B:Q13	B:B:Q9	1.28	No	No	0	1	3
948	A:A:S306	A:A:Y253	1.27	No	Yes	0	7	8
949	A:A:N392	R:R:F61	1.21	No	Yes	0	7	7
950	A:A:N392	R:R:R213	1.21	No	No	0	7	7
951	B:B:L4	B:B:R8	1.21	No	No	0	4	3
952	A:A:D27	A:A:R31	1.19	Yes	No	0	6	4
953	B:B:D212	B:B:R214	1.19	Yes	No	0	9	9
954	A:A:E35	A:A:R39	1.16	No	No	0	4	5
955	B:B:E12	B:B:R8	1.16	No	No	0	4	3
956	A:A:D310	A:A:Y311	1.15	No	No	0	3	6
957	R:R:F250	R:R:R246	1.07	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:D27	4.5125	4	2	6
2	A:A:L45	5.345	4	0	8
3	A:A:F219	8.27	4	0	8
4	A:A:F222	11.735	4	1	7
5	A:A:K233	5.1225	4	0	9
6	A:A:W234	6.104	5	1	9
7	A:A:F238	9.79	4	0	9
8	A:A:F246	5.5525	4	0	9
9	A:A:Y253	5.748	5	0	8
10	A:A:R265	6.2425	4	14	9
11	A:A:W277	9.664	5	0	6
12	A:A:W281	8.488	5	1	5
13	A:A:R283	5.316	5	0	3
14	A:A:F290	4.6275	4	0	9
15	A:A:N292	4.3775	4	0	9
16	A:A:E314	6.2375	4	4	6
17	A:A:F315	11.8725	4	0	6
18	A:A:Y318	5.59	4	4	6
19	A:A:P321	5.265	4	4	5
20	A:A:E327	6.278	5	4	4
21	A:A:E330	6.852	5	4	3
22	A:A:V334	3.4125	4	4	4
23	A:A:K338	7.865	4	4	5
24	A:A:Y339	7.43667	6	4	3
25	A:A:F340	8.51	6	4	7
26	A:A:E344	6.225	4	4	5
27	A:A:S349	4.32	4	0	7
28	A:A:Y360	9.07	4	0	8
29	A:A:T364	5.925	4	9	9
30	A:A:D368	3.875	4	9	9
31	A:A:N371	6.5275	4	9	9
32	A:A:R374	7.528	5	9	4
33	A:A:F376	7.19	5	0	8
34	A:A:N387	4.7025	4	6	8
35	A:A:Y391	10.088	5	6	4
36	B:B:I18	4.8225	4	3	7
37	B:B:R22	6.4325	4	3	6
38	B:B:V40	3.96833	6	17	3
39	B:B:H54	9.74833	6	2	9
40	B:B:K57	9.5	5	1	9
41	B:B:Y59	10.4175	4	1	8
42	B:B:M61	4.535	4	2	6
43	B:B:W63	6.96333	6	2	7
44	B:B:V71	3.7575	4	0	8
45	B:B:S72	6.015	4	2	9
46	B:B:S74	6.9175	4	2	9
47	B:B:Q75	6.5875	4	1	9
48	B:B:W82	9.86	7	2	9
49	B:B:N88	3.725	4	0	7
50	B:B:K89	6.36857	7	2	9
51	B:B:H91	4.265	4	0	5
52	B:B:I93	5.79	4	0	7
53	B:B:W99	8.12857	7	1	9
54	B:B:Y105	4.22167	6	0	6
55	B:B:Y111	7.855	4	0	4
56	B:B:L117	3.9525	4	1	9
57	B:B:I123	5.27	4	0	6
58	B:B:Y124	7.0575	4	0	6
59	B:B:H142	8.21	4	1	9
60	B:B:Y145	5.92857	7	1	8
61	B:B:L146	3.915	4	1	7
62	B:B:F151	5.6975	4	0	9
63	B:B:L152	5.32	4	0	3
64	B:B:I157	4.63	4	1	7
65	B:B:T159	4.984	5	1	9
66	B:B:G162	3.8	4	1	9
67	B:B:D163	8.7475	4	1	9
68	B:B:W169	7.65833	6	1	8
69	B:B:Q176	6.7975	4	1	4
70	B:B:F180	8.9025	4	5	7
71	B:B:H183	6.77714	7	5	9
72	B:B:V187	4.74	4	5	9
73	B:B:R197	6.725	4	11	5
74	B:B:L198	3.835	4	11	3
75	B:B:F199	8.3425	4	5	9
76	B:B:D205	7.0475	4	5	9
77	B:B:K209	9.304	5	5	6
78	B:B:W211	9.08333	6	5	8
79	B:B:D212	8.76	5	11	9
80	B:B:R219	4.0375	4	11	5
81	B:B:F222	7.535	4	3	8
82	B:B:H225	7.12286	7	3	9
83	B:B:I232	5.4125	4	0	8
84	B:B:F235	5.585	6	1	6
85	B:B:P236	6.725	4	1	7
86	B:B:F241	7.085	4	3	6
87	B:B:D247	10.905	4	3	9
88	B:B:T249	6.608	5	3	6
89	B:B:R251	10.416	5	3	8
90	B:B:F253	7.436	5	3	6
91	B:B:D258	8.956	5	3	7
92	B:B:E260	8.3475	4	3	6
93	B:B:Y264	6.142	5	1	5
94	B:B:S277	2.8275	4	0	5
95	B:B:F278	6.4475	4	1	7
96	B:B:R283	5.9875	4	17	9
97	B:B:L285	4.57833	6	1	6
98	B:B:Y289	6.385	8	1	7
99	B:B:D290	5.4675	4	1	6
100	B:B:W297	5.768	5	1	8
101	B:B:K301	5.6775	4	0	5
102	B:B:H311	10.055	4	8	9
103	B:B:R314	13.5775	4	1	8
104	B:B:L318	5.15	4	19	6
105	B:B:W332	11.2714	7	1	9
106	B:B:F335	5.216	5	8	4
107	B:B:W339	8.29	5	8	9
108	G:G:K20	3.6725	4	20	6
109	G:G:I25	4.6225	4	3	2
110	G:G:R27	6.31	5	3	8
111	G:G:V54	5.495	4	21	6
112	G:G:P60	7.0675	4	10	9
113	G:G:F61	5.43875	8	10	8
114	R:R:F61	5.712	5	6	7
115	R:R:Y64	8.514	5	0	7
116	R:R:D72	8.345	4	0	9
117	R:R:F75	6.332	5	0	6
118	R:R:L76	3.6625	4	0	7
119	R:R:R79	9.135	4	0	6
120	R:R:Y99	13.806	5	7	3
121	R:R:Y106	7.245	4	0	7
122	R:R:F107	5.89667	6	7	6
123	R:R:F112	4.88286	7	12	7
124	R:R:L113	5.3975	4	23	8
125	R:R:Y130	10.11	6	6	7
126	R:R:R134	8.864	5	6	9
127	R:R:W147	5.685	4	12	9
128	R:R:R153	6.945	4	7	4
129	R:R:E157	6.78	5	7	4
130	R:R:F165	3.6625	4	0	1
131	R:R:D177	6.1675	4	7	4
132	R:R:L214	5.2775	4	0	7
133	R:R:F225	5.36	5	0	8
134	R:R:F232	5.395	4	0	5
135	R:R:F237	5.60667	6	7	5
136	R:R:W241	4.07	4	0	3
137	R:R:F259	5.235	4	0	5
138	R:R:N268	5.97	4	23	9
139	R:R:I271	4.8475	4	0	8
140	R:R:Y272	6.036	5	23	9
141	R:R:F273	6.6525	4	22	7
142	R:R:F274	5.4875	4	22	7
143	L:L:?1	9.24222	9	7	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:D83	B:B:L69	12.0843	4.07	No	No	0	8	5
2	B:B:L69	B:B:Y105	18.6838	3.52	No	Yes	0	5	6
3	B:B:V71	B:B:Y105	28.0699	3.79	Yes	Yes	0	8	6
4	B:B:I81	B:B:V71	28.9849	4.61	No	Yes	0	7	8
5	B:B:H91	B:B:I81	29.1359	3.98	Yes	No	0	5	7
6	B:B:H91	B:B:V133	29.5885	4.15	Yes	No	0	5	4
7	B:B:I93	B:B:V133	29.7392	4.61	Yes	No	0	7	4
8	B:B:I93	B:B:L79	31.2336	4.28	Yes	No	0	7	7
9	B:B:C114	B:B:L79	32.7948	4.76	No	No	0	8	7
10	B:B:C114	B:B:G115	33.0933	3.92	No	No	0	8	9
11	B:B:G115	B:B:L146	33.2425	3.42	No	Yes	0	9	7
12	B:B:L146	B:B:T159	33.5235	5.9	Yes	Yes	1	7	9
13	B:B:H142	B:B:T159	37.3986	4.11	Yes	Yes	1	9	9
14	B:B:H142	B:B:S161	45.7662	16.74	Yes	No	1	9	9
15	B:B:G162	B:B:S161	46.5326	3.71	Yes	No	1	9	9
16	B:B:G162	B:B:Y145	47.0703	4.35	Yes	Yes	1	9	8
17	A:A:W234	B:B:Y145	45.4433	3.86	Yes	Yes	1	9	8
18	A:A:I235	A:A:W234	23.1715	3.52	No	Yes	0	9	9
19	A:A:I235	A:A:N279	23.2053	4.25	No	No	0	9	8
20	A:A:L282	A:A:N279	23.2391	6.87	No	No	0	9	8
21	A:A:I244	A:A:L282	23.0758	4.28	No	No	0	8	9
22	A:A:I244	A:A:V287	98.4864	3.07	No	No	0	8	6
23	A:A:F273	A:A:V287	98.4972	6.55	No	No	0	9	6
24	A:A:F273	A:A:F345	98.8615	10.72	No	No	0	9	8
25	A:A:F345	A:A:L270	99.6143	8.53	No	No	0	8	6
26	A:A:E344	A:A:L270	99.6529	5.3	Yes	No	0	5	6
27	A:A:E344	A:A:F340	99.3027	9.33	Yes	Yes	4	5	7
28	A:A:F315	A:A:F340	99.4732	15	Yes	Yes	0	6	7
29	A:A:F315	A:A:I308	99.6481	15.07	Yes	No	0	6	7
30	A:A:I308	A:A:Y253	99.6572	8.46	No	Yes	0	7	8
31	A:A:K300	A:A:Y253	99.9924	8.36	No	Yes	0	9	8
32	A:A:K300	A:A:S251	100	6.12	No	No	0	9	9
33	A:A:D249	A:A:S251	49.9144	8.83	No	No	0	8	9
34	A:A:D249	A:A:K293	49.8882	8.3	No	No	0	8	9
35	A:A:K293	A:A:N292	99.7904	6.99	No	Yes	0	9	9
36	A:A:N292	A:A:T364	98.28	4.39	Yes	Yes	0	9	9
37	A:A:R374	A:A:T364	95.435	3.88	Yes	Yes	9	4	9
38	A:A:E370	A:A:R374	94.8992	16.28	No	Yes	9	4	4
39	A:A:E370	A:A:R373	95.2769	9.3	No	No	0	4	5
40	A:A:R373	A:A:V214	95.0948	3.92	No	No	0	5	6
41	A:A:F376	A:A:V214	95.0036	3.93	Yes	No	0	8	6
42	A:A:F238	A:A:W234	22.9442	5.01	Yes	Yes	0	9	9
43	A:A:F238	A:A:V241	75.4166	3.93	Yes	No	0	9	9
44	A:A:I285	A:A:V241	75.4454	3.07	No	No	0	7	9
45	A:A:I244	A:A:I285	75.4742	4.42	No	No	0	8	7
46	A:A:L296	A:A:S251	50.0933	7.51	No	No	0	6	9
47	A:A:K293	A:A:L296	49.9885	4.23	No	No	0	9	6
48	A:A:F219	A:A:F376	93.8114	8.57	Yes	Yes	0	8	8
49	A:A:F219	A:A:L41	93.2262	8.53	Yes	No	0	8	6
50	B:B:Q75	B:B:W99	52.0916	5.48	Yes	Yes	1	9	9
51	B:B:K57	B:B:Q75	26.0555	5.42	Yes	Yes	1	9	9
52	B:B:W332	B:B:Y59	26.8721	10.61	Yes	Yes	1	9	8
53	A:A:W281	B:B:D290	22.3204	6.7	Yes	Yes	1	5	6
54	B:B:R314	B:B:W332	31.2434	29.99	Yes	Yes	1	8	9
55	A:A:I383	A:A:L41	93.071	2.85	No	No	0	8	6
56	A:A:I383	A:A:N387	92.7317	4.25	No	Yes	6	8	8
57	A:A:N387	R:R:S123	33.2829	7.45	Yes	No	6	8	8
58	A:A:Y391	R:R:S123	33.171	7.63	Yes	No	6	4	8
59	A:A:Y391	R:R:F61	33.3339	12.38	Yes	Yes	6	4	7
60	R:R:F61	R:R:I65	31.9482	7.54	Yes	No	0	7	8
61	R:R:I65	R:R:Y272	31.7114	4.84	No	Yes	0	8	9
62	R:R:L113	R:R:Y272	32.2501	5.86	Yes	Yes	23	8	9
63	R:R:F225	R:R:L113	32.1447	6.09	Yes	Yes	0	8	8
64	R:R:F225	R:R:L226	13.1726	3.65	Yes	No	0	8	6
65	A:A:N387	R:R:Y130	59.4159	3.49	Yes	Yes	6	8	7
66	A:A:Y391	R:R:Y130	33.2315	11.91	Yes	Yes	6	4	7
67	A:A:Y391	R:R:R120	32.0948	6.17	Yes	No	0	4	9
68	R:R:R120	R:R:T221	31.8579	9.06	No	No	0	9	8
69	R:R:T221	R:R:Y272	31.6213	8.74	No	Yes	0	8	9
70	B:B:C271	B:B:D290	42.5454	4.67	No	Yes	1	5	6
71	B:B:C271	B:B:Y289	41.0313	4.03	No	Yes	1	5	7
72	B:B:W297	B:B:Y289	37.1298	5.79	Yes	Yes	1	8	7
73	B:B:W297	B:B:Y264	28.3257	7.72	Yes	Yes	1	8	5
74	B:B:L252	B:B:Y264	27.2282	5.86	No	Yes	0	7	5
75	B:B:L252	B:B:L261	26.6233	4.15	No	No	0	7	5
76	B:B:D254	B:B:L261	26.0181	4.07	No	No	0	9	5
77	B:B:A257	B:B:D254	25.4125	4.63	No	No	0	7	9
78	B:B:A257	B:B:Q259	25.1096	3.03	No	No	0	7	6
79	B:B:Q259	B:B:R22	24.5036	8.18	No	Yes	0	6	6
80	B:B:D258	B:B:R22	16.2806	9.53	Yes	Yes	3	7	6
81	B:B:R314	B:B:T274	11.9143	5.17	Yes	No	0	8	8
82	B:B:S275	B:B:T274	11.7391	3.2	No	No	0	8	8
83	B:B:L318	B:B:S275	11.5638	6.01	Yes	No	0	6	8
84	B:B:R68	B:B:Y85	12.2585	16.46	No	No	0	5	4
85	B:B:D258	B:B:F222	15.1064	5.97	Yes	Yes	3	7	8
86	R:R:N268	R:R:Y272	28.6706	3.49	Yes	Yes	23	9	9
87	R:R:N264	R:R:N268	17.5521	8.17	No	Yes	0	9	9
88	R:R:C228	R:R:N264	16.0071	3.15	No	No	0	8	9
89	R:R:C228	R:R:L263	14.9767	3.17	No	No	0	8	5
90	R:R:L263	R:R:V37	14.4614	2.98	No	No	0	5	7
91	R:R:L33	R:R:V37	13.946	2.98	No	No	0	6	7
92	R:R:F259	R:R:L33	13.4305	8.53	Yes	No	0	5	6
93	R:R:D72	R:R:N268	11.8046	6.73	Yes	Yes	0	9	9
94	R:R:D72	R:R:S265	12.8173	11.78	Yes	No	0	9	9
95	R:R:E119	R:R:Y130	25.5599	12.35	No	Yes	6	9	7
96	R:R:E119	R:R:Y64	25.4884	16.83	No	Yes	0	9	7
97	R:R:C143	R:R:Y64	23.0369	4.03	No	Yes	0	7	7
98	R:R:C143	R:R:F112	13.3315	5.59	No	Yes	12	7	7
99	R:R:F225	R:R:L110	13.4912	6.09	Yes	No	0	8	7
100	R:R:L110	R:R:Y106	12.9999	9.38	No	Yes	0	7	7
101	R:R:F104	R:R:W147	18.2329	6.01	No	Yes	0	5	9
102	R:R:F104	R:R:S154	17.7328	1.32	No	No	0	5	6
103	R:R:R153	R:R:S154	17.4849	1.32	Yes	No	0	4	6
104	R:R:E157	R:R:R153	10.9734	9.3	Yes	Yes	7	4	4
105	R:R:F107	R:R:Y106	11.624	6.19	Yes	Yes	0	6	7
106	A:A:F238	B:B:W99	52.5558	18.04	Yes	Yes	0	9	9
107	B:B:K57	B:B:W332	25.9618	16.24	Yes	Yes	1	9	9
108	A:A:W281	B:B:W332	20.7274	4.69	Yes	Yes	1	5	9
109	B:B:Q75	B:B:Y59	25.9331	12.4	Yes	Yes	1	9	8
110	B:B:D290	B:B:R314	20.8212	7.15	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S95	R:R:Y82	3.82	0	No	No	7	3	2	1
R:R:L98	R:R:Y82	3.52	0	No	No	4	3	2	1
L:L:?1	R:R:Y82	3.07	7	Yes	No	0	3	0	1
L:L:?1	R:R:K96	9.84	7	Yes	No	0	5	0	1
R:R:P100	R:R:Y99	6.95	0	No	Yes	4	3	2	1
R:R:M103	R:R:Y99	13.17	0	No	Yes	2	3	2	1
R:R:E157	R:R:Y99	8.98	7	Yes	Yes	4	3	1	1
R:R:F236	R:R:Y99	7.22	0	No	Yes	4	3	2	1
L:L:?1	R:R:Y99	32.71	7	Yes	Yes	0	3	0	1
R:R:E157	R:R:R153	9.3	7	Yes	Yes	4	4	1	2
R:R:E157	R:R:F237	4.66	7	Yes	Yes	4	5	1	2
L:L:?1	R:R:E157	8.09	7	Yes	Yes	0	4	0	1
R:R:C161	R:R:C173	7.28	7	No	No	4	9	1	1
L:L:?1	R:R:C161	6.92	7	Yes	No	0	4	0	1
R:R:C173	R:R:D177	4.67	7	No	Yes	9	4	1	1
L:L:?1	R:R:C173	5.54	7	Yes	No	0	9	0	1
R:R:D177	R:R:F237	3.58	7	Yes	Yes	4	5	1	2
R:R:D177	R:R:L240	8.14	7	Yes	No	4	4	1	1
L:L:?1	R:R:D177	8.28	7	Yes	Yes	0	4	0	1
R:R:F236	R:R:F237	6.43	0	No	Yes	4	5	2	2
L:L:?1	R:R:L240	7.24	7	Yes	No	0	4	0	1
R:R:E157	R:R:S176	2.87	7	Yes	No	4	3	1	2
R:R:G162	R:R:S166	1.86	0	No	No	2	1	1	2
L:L:?1	R:R:G162	1.49	7	Yes	No	0	2	0	1
R:R:H92	R:R:K96	1.31	0	No	No	1	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
58.33	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
37.50	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
36.36	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
35.29	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
31.58	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
30.77	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
26.09	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.00	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
23.81	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
23.08	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
23.08	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
23.08	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
23.08	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
22.73	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.22	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
22.22	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.74	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
21.43	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
21.43	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
21.05	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
21.05	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
21.05	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
20.83	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.83	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
20.00	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
20.00	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
20.00	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
20.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
20.00	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
20.00	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
20.00	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
20.00	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
19.23	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.05	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.05	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
19.05	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
19.05	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
19.05	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
18.75	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
18.75	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
18.75	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
18.75	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
18.75	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.75	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
18.75	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
18.75	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
18.75	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
18.75	Consensus	hcar_on	Orthosteric Ligand	hca_on
18.75	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
18.18	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
18.18	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
18.18	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.18	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
18.18	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
18.18	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.18	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
18.18	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
17.65	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
17.65	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
17.65	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
17.65	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
17.65	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
17.65	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.65	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
17.65	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
17.65	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
17.65	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
17.65	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
17.65	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
17.65	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.65	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.39	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
17.39	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
17.39	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
17.39	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
17.39	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
16.67	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
16.67	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
16.67	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
16.67	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
16.67	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
16.67	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.67	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.67	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
16.67	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
16.67	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
16.67	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
16.67	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
16.67	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
16.67	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
16.67	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.67	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
16.67	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.67	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
16.67	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
16.67	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.67	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
16.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
16.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
16.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
16.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.00	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.79	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
15.79	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
15.79	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
15.79	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
15.79	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
15.79	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
15.79	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
15.79	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
15.79	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
15.79	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.79	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
15.79	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
15.79	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
15.79	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
15.79	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
15.79	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
15.79	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
15.79	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.79	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
15.79	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.38	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.38	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
15.38	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
15.38	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
15.38	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
15.38	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
15.38	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
15.38	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
15.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
15.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
15.00	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
15.00	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
15.00	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
15.00	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
15.00	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
15.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
15.00	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.00	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
15.00	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.00	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
15.00	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
15.00	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
15.00	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
15.00	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
15.00	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
15.00	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
15.00	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
15.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
15.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
15.00	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
15.00	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
15.00	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
15.00	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
15.00	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
15.00	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.81	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
14.81	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
14.81	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
14.81	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.81	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
14.81	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
14.81	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
14.29	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
14.29	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
14.29	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
14.29	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
14.29	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
14.29	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
14.29	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
14.29	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
14.29	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
14.29	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
14.29	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
14.29	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
14.29	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
14.29	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
14.29	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
14.29	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
14.29	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
14.29	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
14.29	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
14.29	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
13.79	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
13.79	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.64	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
13.64	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
13.64	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
13.64	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
13.64	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.64	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
13.64	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.64	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
13.64	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
13.64	Consensus	class-d_off	Orthosteric Ligand	ste2_off
13.64	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
13.64	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
13.64	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.64	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
13.64	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
13.64	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
13.64	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
13.64	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
13.64	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
13.33	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
13.33	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
13.33	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
13.33	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
13.33	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
13.33	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
13.33	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
13.33	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
13.33	Consensus	class-t_on	Orthosteric Ligand	taste2_on
13.33	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
13.33	Consensus	go_protein	Orthosteric Ligand	go_chemokine
13.33	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
13.33	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.04	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
13.04	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.04	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
13.04	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
13.04	Single	7QA8	Peptide	7QA8-STE2-Peptide
13.04	Single	7QA8	Peptide	7QA8-STE2-Peptide
13.04	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
13.04	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
13.04	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
13.04	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
13.04	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
13.04	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
13.04	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.04	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.04	Consensus	class-d_off	Orthosteric Ligand	ste2_off
13.04	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
13.04	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
13.04	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
13.04	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
12.50	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
12.50	Single	5WS3	EMPA	5WS3-OX₂-EMPA
12.50	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
12.50	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
12.50	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
12.50	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
12.50	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
12.50	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
12.50	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
12.50	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
12.50	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
12.50	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
12.50	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
12.50	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
12.50	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
12.50	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
12.50	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
12.50	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
12.50	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
12.50	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
12.50	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
12.50	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
12.50	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
12.50	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
12.50	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
12.50	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
12.50	Consensus	sst_off	Orthosteric Ligand	sst2_off
12.12	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
12.12	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
12.12	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
12.00	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
12.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
12.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
12.00	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
12.00	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
12.00	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
12.00	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
12.00	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
12.00	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
11.76	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
11.76	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
11.76	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
11.76	Single	6IQL	L745870	6IQL-D₄-L745870
11.76	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
11.76	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
11.76	Single	6TPG	EMPA	6TPG-OX₂-EMPA
11.76	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
11.76	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
11.76	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
11.76	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
11.76	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
11.76	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.76	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
11.76	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
11.76	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
11.76	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
11.76	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.76	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
11.76	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.76	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
11.76	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.76	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
11.76	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
11.76	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
11.76	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
11.76	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
11.76	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
11.76	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
11.54	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
11.54	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
11.54	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
11.54	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
11.11	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
11.11	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
11.11	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
11.11	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
11.11	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
11.11	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
11.11	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
11.11	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
11.11	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
11.11	Single	6GPS	MK0812	6GPS-CCR2-MK0812
11.11	Single	6IIV	Daltroban	6IIV-TP-Daltroban
11.11	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
11.11	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
11.11	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
11.11	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.11	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
11.11	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
11.11	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
11.11	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.11	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
11.11	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
11.11	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.11	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
11.11	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
11.11	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
11.11	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
11.11	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
11.11	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
11.11	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
11.11	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
11.11	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
11.11	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
11.11	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
11.11	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
11.11	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
11.11	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
11.11	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.11	Consensus	cck_off	Orthosteric Ligand	ccka_off
11.11	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
11.11	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
11.11	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.11	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	hcar_off	Orthosteric Ligand	succinate_off
11.11	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
11.11	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
11.11	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.11	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
10.71	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
10.71	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
10.71	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.71	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71	Consensus	class-d_on	Orthosteric Ligand	ste2_on
10.71	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.71	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.71	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.53	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
10.53	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
10.53	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
10.53	Single	5WQC	EMPA	5WQC-OX₂-EMPA
10.53	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
10.53	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
10.53	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
10.53	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
10.53	Single	6GPX	MK0812	6GPX-CCR2-MK0812
10.53	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
10.53	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
10.53	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.53	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
10.53	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
10.53	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
10.53	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
10.53	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
10.53	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
10.53	Single	7C4S	S1P	7C4S-S1P₃-S1P
10.53	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
10.53	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
10.53	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
10.53	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
10.53	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
10.53	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.53	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.53	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
10.53	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
10.53	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
10.53	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.53	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
10.53	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
10.53	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.53	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
10.53	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.53	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
10.53	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
10.53	Consensus	ep_off	Orthosteric Ligand	ep4_off
10.53	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
10.53	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.34	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
10.34	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
10.34	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.34	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
10.34	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.34	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
10.34	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
10.34	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.26	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.00	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
10.00	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
10.00	Single	4DJH	JDTic	4DJH-κ-JDTic
10.00	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
10.00	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
10.00	Single	5X93	K-8794	5X93-ET_B-K-8794
10.00	Single	5XR8	AM841	5XR8-CB₁-AM841
10.00	Single	5XRA	AM11542	5XRA-CB₁-AM11542
10.00	Single	6E59	L-760735	6E59-NK₁-L-760735
10.00	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
10.00	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
10.00	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
10.00	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
10.00	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00	Single	6OS1	TRV026	6OS1-AT₁-TRV026
10.00	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
10.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
10.00	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
10.00	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
10.00	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
10.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
10.00	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
10.00	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
10.00	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
10.00	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
10.00	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
10.00	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
10.00	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
10.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
10.00	Single	7W41	PD176252	7W41-BB₂-PD176252
10.00	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
10.00	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.00	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
10.00	Single	8E0G	BU72	8E0G-μ-BU72
10.00	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
10.00	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
10.00	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
10.00	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
10.00	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
10.00	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.00	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
10.00	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
10.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
10.00	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
10.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
10.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
10.00	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
10.00	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
10.00	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.00	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
10.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
10.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
10.00	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
10.00	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
10.00	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
10.00	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
10.00	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
10.00	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
10.00	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
10.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
10.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
10.00	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
10.00	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
9.68	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
9.68	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
9.68	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.68	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
9.68	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.68	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
9.52	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
9.52	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
9.52	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
9.52	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
9.52	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
9.52	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
9.52	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
9.52	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
9.52	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
9.52	Single	6OS2	TRV026	6OS2-AT₁-TRV026
9.52	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
9.52	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.52	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
9.52	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
9.52	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
9.52	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
9.52	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
9.52	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
9.52	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
9.52	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
9.52	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
9.52	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
9.52	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
9.52	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
9.52	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.52	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.52	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
9.52	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
9.52	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
9.52	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
9.52	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.52	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
9.52	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.52	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
9.52	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
9.52	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
9.52	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
9.52	Consensus	blt_off	Orthosteric Ligand	blt1_off
9.52	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
9.52	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
9.52	Consensus	dp_off	Orthosteric Ligand	dp2_off
9.52	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
9.52	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
9.52	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
9.52	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
9.52	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
9.52	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
9.52	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
9.52	Consensus	nts_off	Orthosteric Ligand	nts1_off
9.52	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
9.52	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.38	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
9.38	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
9.38	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
9.09	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
9.09	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
9.09	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
9.09	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
9.09	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
9.09	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
9.09	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
9.09	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
9.09	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
9.09	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
9.09	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
9.09	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
9.09	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
9.09	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
9.09	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
9.09	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
9.09	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
9.09	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
9.09	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
9.09	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
9.09	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.09	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
9.09	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
9.09	Consensus	endothelin_off	Orthosteric Ligand	etb_off
9.09	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
9.09	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
9.09	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
9.09	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
9.09	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
9.09	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
9.09	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
9.09	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	orexin_on	Orthosteric Ligand	ox2_on
9.09	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
8.82	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
8.82	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
8.70	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
8.70	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.70	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
8.70	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.70	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.70	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
8.70	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
8.70	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
8.70	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
8.70	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
8.70	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
8.70	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
8.57	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
8.33	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
8.33	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
8.33	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.33	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
8.33	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
8.33	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
8.33	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.33	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
8.33	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
8.33	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
8.33	Single	8WCB	Cyclohexylammonium ion	8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	8WCC	Cyclohexylammonium ion	8WCC-TA1-Cyclohexylammonium ion
8.33	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
8.33	Consensus	ccr8_off	Orthosteric Ligand	8TLM-CCR8-Anti-murine CCR8 antibody
8.33	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.33	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
8.33	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.11	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.00	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
8.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
8.00	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.00	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
8.00	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
8.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
8.00	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
8.00	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
8.00	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
8.00	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
7.69	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
7.69	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.69	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
7.69	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
7.69	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.69	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.69	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
7.69	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
7.41	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
7.41	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.41	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
7.41	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.41	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
7.41	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.41	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
7.41	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.41	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
7.41	Consensus	class-d_on	Orthosteric Ligand	ste2_on
7.41	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
7.41	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.41	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
7.41	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
7.41	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
7.14	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
7.14	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
7.14	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
7.14	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
7.14	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
7.14	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.14	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
7.14	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
7.14	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
7.14	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
7.14	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
7.14	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
7.14	Consensus	hca2_on_allo	Orthosteric Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
7.14	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
6.90	Single	6FJ3	PTH	6FJ3-PTH1-PTH
6.90	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.90	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
6.90	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.90	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
6.90	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
6.90	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.90	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
6.90	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
6.90	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
6.90	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.67	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.67	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
6.67	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
6.67	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.67	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
6.67	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.67	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
6.67	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
6.67	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
6.67	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
6.67	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
6.67	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.67	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
6.67	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
6.67	Single	7MT8	All-trans-retinal	7MT8-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	7MT9	All-trans-retinal	7MT9-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	7MTA	All-trans-retinal	7MTA-Rhodopsin-All-trans-retinal-GRK1
6.67	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
6.67	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.67	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.67	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
6.67	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
6.67	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
6.67	Consensus	go_class-b1	Orthosteric Ligand	go_crf
6.67	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
6.67	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
6.67	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
6.45	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.45	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.45	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.45	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
6.45	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.45	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.45	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
6.45	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
6.45	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.45	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.45	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.25	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
6.25	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
6.25	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
6.25	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
6.25	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
6.25	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
6.25	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.25	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
6.25	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
6.25	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
6.25	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.25	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
6.25	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
6.25	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
6.25	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
6.25	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
6.25	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.25	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
6.25	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
6.25	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.25	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.25	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
6.25	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.25	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.25	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25	Consensus	mt1_on	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
6.25	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
6.25	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
6.06	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
6.06	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.06	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
5.88	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.88	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
5.88	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
5.88	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
5.88	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
5.88	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
5.88	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
5.88	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
5.88	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
5.88	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
5.88	Single	5U09	Taranabant	5U09-CB₁-Taranabant
5.88	Single	6AKX	A4R	6AKX-CCR5-A4R
5.88	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
5.88	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.88	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
5.88	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.88	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.88	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
5.88	Single	6OYA	All-trans-retinal	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.88	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
5.88	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
5.88	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
5.88	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.88	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.88	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
5.88	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.88	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.88	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88	Single	7TUZ	7alpha,25-dihydroxycholesterol	7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
5.88	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.88	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
5.88	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.88	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
5.88	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
5.88	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.88	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.88	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.88	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.88	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.88	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.88	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
5.88	Consensus	class-f_off	Orthosteric Ligand	smo_off
5.88	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
5.88	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.88	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.88	Consensus	gt_class-a	Orthosteric Ligand	gt_opsin
5.88	Consensus	gt_opsin	Orthosteric Ligand	gt_sensory
5.88	Consensus	gt_sensory	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.88	Consensus	melatonin_on	Orthosteric Ligand	mt1_on mt2_on
5.88	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
5.88	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
5.88	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.88	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
5.71	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.71	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
5.71	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.56	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.56	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
5.56	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
5.56	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
5.56	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
5.56	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
5.56	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
5.56	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
5.56	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
5.56	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.56	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
5.56	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
5.56	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.56	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.56	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.56	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.56	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
5.56	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.56	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.56	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
5.56	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
5.56	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
5.56	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
5.56	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
5.56	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
5.56	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
5.56	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
5.56	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.56	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
5.56	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
5.56	Single	7T32	ZM241385	7T32-A_2A-ZM241385
5.56	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
5.56	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.56	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
5.56	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
5.56	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
5.56	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
5.56	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
5.56	Single	8IYX	YL-365	8IYX-GPR34-YL-365
5.56	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
5.56	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/&β;1/&γ;2
5.56	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2
5.56	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.56	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
5.56	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.56	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
5.56	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56	Consensus	gi_melatonin	Orthosteric Ligand	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
5.56	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
5.56	Consensus	gs_tar	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.56	Consensus	sensory_off	Orthosteric Ligand	opsin_off
5.56	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
5.41	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.26	Single	3EML	ZM241385	3EML-A_2A-ZM241385
5.26	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
5.26	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.26	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
5.26	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.26	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
5.26	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
5.26	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
5.26	Single	5UEN	DU172	5UEN-A₁-DU172
5.26	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
5.26	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
5.26	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.26	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.26	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.26	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.26	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
5.26	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
5.26	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.26	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
5.26	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.26	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
5.26	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
5.26	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.26	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.26	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.26	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
5.26	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
5.26	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
5.26	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
5.26	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
5.26	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.26	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.26	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
5.26	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
5.26	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
5.26	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
5.26	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.26	Single	8J18	(3R)-3-hydroxydodecanoic acid	8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
5.26	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.26	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.26	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
5.26	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
5.26	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
5.26	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.26	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.26	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
5.26	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
5.26	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.26	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.26	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.26	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.26	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
5.26	Consensus	leuko_on	Orthosteric Ligand	blt_on
5.26	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
5.26	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
5.26	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.26	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
5.26	Consensus	tar_on	Orthosteric Ligand	ta1_on
5.13	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
5.00	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
5.00	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
5.00	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
5.00	Single	5C1M	BU72	5C1M-μ-BU72
5.00	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
5.00	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
5.00	Single	5N2S	PSB36	5N2S-A₁-PSB36
5.00	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
5.00	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
5.00	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
5.00	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.00	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
5.00	Single	5ZK3	Quinuclidinyl benzilate hydrobromide	5ZK3-M₂-Quinuclidinyl benzilate hydrobromide
5.00	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
5.00	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
5.00	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
5.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.00	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
5.00	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
5.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
5.00	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.00	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.00	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
5.00	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
5.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.00	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.00	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.00	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
5.00	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
5.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.00	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
5.00	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
5.00	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
5.00	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
5.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.00	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
5.00	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
5.00	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
5.00	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
5.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.00	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
5.00	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
5.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.00	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
5.00	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.88	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
4.76	Single	2YDV	NECA	2YDV-A_2A-NECA
4.76	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
4.76	Single	3UON	Quinuclidinyl benzilate hydrobromide	3UON-M₂-Quinuclidinyl benzilate hydrobromide
4.76	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
4.76	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.76	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.76	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.76	Single	5V56	TC114	5V56-SMO-TC114
4.76	Single	5V57	TC114	5V57-SMO-TC114
4.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.76	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.76	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.76	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
4.76	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
4.76	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
4.76	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.76	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
4.76	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
4.76	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
4.76	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
4.76	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/&β;1/&γ;2
4.76	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
4.76	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
4.76	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
4.76	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
4.76	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
4.76	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
4.76	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
4.76	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
4.76	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
4.76	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
4.76	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
4.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
4.76	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
4.76	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.76	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
4.76	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
4.76	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
4.76	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
4.76	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
4.76	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
4.76	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
4.76	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
4.76	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.76	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.76	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
4.55	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.55	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.55	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
4.55	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.55	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.55	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
4.55	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
4.55	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.55	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.55	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
4.55	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.55	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
4.55	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.55	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
4.55	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
4.55	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
4.55	Consensus	gi_class-f	Other Ligand	gi_frizzled
4.55	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.55	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.55	Consensus	nts_on	Orthosteric Ligand	nts1_on
4.55	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
4.35	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.35	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.35	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.35	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
4.35	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
4.35	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.35	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
4.35	Single	7EZC	UKA	7EZC-A_2A-UKA
4.35	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
4.35	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
4.35	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.35	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
4.35	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
4.35	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
4.35	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.35	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.35	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
4.35	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
4.35	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.17	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
4.17	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.17	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
4.17	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.17	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
4.17	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
4.17	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.17	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
4.17	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.17	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.17	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.17	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
4.17	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
4.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
3.85	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.85	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.85	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
3.85	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
3.85	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
3.70	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.70	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.70	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.70	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
3.57	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
3.57	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.57	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
3.45	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.45	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.45	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.45	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.33	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.33	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.33	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.23	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.23	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.23	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.23	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.12	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.12	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.12	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
3.12	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.03	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.94	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.86	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.78	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.70	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.70	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.70	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.63	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.50	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.44	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.44	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	8DWH
Class	A
SubFamily	Orphan
Type	A orphans
SubType	MRGPRX1
Species	Homo sapiens
Ligand	Compound-16
Other Ligand(s)	-
Protein Partners	chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution	3.25
Date	2022-11-02
D.O.I.	10.1038/s41589-022-01173-6

Net Summary
I_min	3.03
Number of Linked Nodes	812
Number of Links	957
Number of Hubs	143
Number of Links mediated by Hubs	534
Number of Communities	24
Number of Nodes involved in Communities	197
Number of Links involved in Communities	280

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	2959140
Length Of Smallest Path	3
Average Path Length	48.6216
Length of Longest Path	76
Minimum Path Strength	1.185
Average Path Strength	6.90377
Maximum Path Strength	23.115
Minimum Path Correlation	0.7
Average Path Correlation	0.987909
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.17391
Average % Of Corr. Nodes	28.6782
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.0945
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U2U
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U2U
Name	N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide
Synonyms
Identifier	~{N}-[2-(1-azanylisoquinolin-6-yl)oxy-4-methyl-phenyl]-2-methoxy-benzenesulfonamide
Formula	C23 H21 N3 O4 S
Molecular Weight	435.496
SMILES	Cc1ccc(c(c1)Oc2ccc3c(c2)ccnc3N)NS(=O)(=O)c4ccccc4OC
PubChem	139030531
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8DWH_Chain_A V S A E D K A A A E R S K M I D K N L R E D G E K A R R T L R L L L L G A D N S G K S T I V K G I F E T K F Q V D K V N F H M F D V G R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R K E F V D I S T A S G D G R H I C Y P H F T C A V D T E N A R R I F N D C K D I I L Q M N L R E Y N L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8DWH_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8DWH_Chain_G Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8DWH_Chain_R K Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I S I P H T I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G F L F S G A D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8DWC	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Proenkephalin-A	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	2.87	2022-11-02	10.1038/s41589-022-01173-6
	8DWG	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWH	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Compound-16	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.25	2022-11-02	10.1038/s41589-022-01173-6
	8HJ5	A	Orphan	A orphans	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	3	2023-05-31	10.1371/journal.pbio.3001975
	8JGB	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/&β;1/&γ;2	2.84	2024-01-10	10.1038/s41467-023-40705-z
	8JGF	A	Orphan	A orphans	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGG	A	Orphan	A orphans	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/&β;1/&γ;2	3	2024-01-10	10.1038/s41467-023-40705-z

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