psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L28	R:R:Q26	3.99	No	No	0	4	1
2	R:R:L30	R:R:T27	10.32	No	No	0	5	4
3	R:R:L28	R:R:T31	5.9	No	No	0	4	4
4	R:R:L33	R:R:S29	3	No	No	0	6	4
5	R:R:F87	R:R:T31	3.89	Yes	No	0	4	4
6	R:R:C35	R:R:S83	5.16	No	No	0	5	6
7	R:R:C35	R:R:F87	2.79	No	Yes	0	5	4
8	R:R:S266	R:R:V37	3.23	No	No	0	7	7
9	R:R:L42	R:R:S38	3	Yes	No	4	7	5
10	R:R:L76	R:R:S38	4.5	Yes	No	4	7	5
11	R:R:L80	R:R:S38	7.51	Yes	No	4	7	5
12	R:R:L39	R:R:L80	4.15	No	Yes	0	5	7
13	R:R:G41	R:R:S266	3.71	No	No	0	9	7
14	R:R:F73	R:R:L42	4.87	No	Yes	0	7	7
15	R:R:L42	R:R:L76	4.15	Yes	Yes	4	7	7
16	R:R:L42	R:R:L80	2.77	Yes	Yes	4	7	7
17	R:R:D72	R:R:N45	4.04	Yes	No	0	9	9
18	R:R:N45	R:R:P269	11.4	No	No	0	9	9
19	R:R:L51	R:R:V47	2.98	No	No	0	7	6
20	R:R:F273	R:R:V48	6.55	Yes	No	0	7	9
21	R:R:L49	R:R:L66	4.15	No	No	0	7	7
22	R:R:L51	R:R:W50	5.69	No	No	0	7	5
23	R:R:F273	R:R:L51	4.87	Yes	No	0	7	7
24	R:R:L52	R:R:M56	5.65	No	No	0	7	6
25	R:R:F273	R:R:L52	12.18	Yes	No	0	7	7
26	R:R:M56	R:R:R57	9.93	No	No	0	6	6
27	R:R:R57	R:R:S62	9.22	No	No	0	6	7
28	R:R:R57	R:R:S277	6.59	No	No	0	6	6
29	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
30	R:R:A60	R:R:S139	3.42	No	No	0	7	9
31	R:R:F61	R:R:I65	8.79	No	No	2	7	8
32	R:R:F61	R:R:Y272	6.19	No	Yes	2	7	9
33	R:R:I63	R:R:S139	7.74	No	No	0	7	9
34	R:R:A115	R:R:Y64	4	No	Yes	0	7	7
35	R:R:V116	R:R:Y64	3.79	No	Yes	0	8	7
36	R:R:E119	R:R:Y64	12.35	No	Yes	0	9	7
37	R:R:S139	R:R:Y64	7.63	No	Yes	0	9	7
38	R:R:V142	R:R:Y64	3.79	No	Yes	0	6	7
39	R:R:C143	R:R:Y64	2.69	No	Yes	0	7	7
40	R:R:I65	R:R:Y272	6.04	No	Yes	2	8	9
41	R:R:F112	R:R:N67	6.04	Yes	No	2	7	9
42	R:R:C143	R:R:N67	6.3	No	No	0	7	9
43	R:R:N67	R:R:W147	3.39	No	Yes	2	9	9
44	R:R:D72	R:R:L68	5.43	Yes	Yes	2	9	9
45	R:R:F112	R:R:L68	3.65	Yes	Yes	2	7	9
46	R:R:L113	R:R:L68	5.54	Yes	Yes	2	8	9
47	R:R:L68	R:R:N268	9.61	Yes	Yes	2	9	9
48	R:R:A71	R:R:F112	2.77	No	Yes	2	9	7
49	R:R:A71	R:R:W147	3.89	No	Yes	2	9	9
50	R:R:D72	R:R:S265	5.89	Yes	No	0	9	9
51	R:R:D72	R:R:N268	9.42	Yes	Yes	2	9	9
52	R:R:L74	R:R:S105	3	No	No	0	7	8
53	R:R:F75	R:R:R79	6.41	Yes	Yes	3	6	6
54	R:R:F75	R:R:M102	3.73	Yes	No	3	6	4
55	R:R:F75	R:R:S105	5.28	Yes	No	0	6	8
56	R:R:F75	R:R:Y106	8.25	Yes	Yes	3	6	7
57	R:R:F75	R:R:S265	7.93	Yes	No	0	6	9
58	R:R:L76	R:R:S265	4.5	Yes	No	0	7	9
59	R:R:I81	R:R:S77	3.1	No	No	0	5	5
60	R:R:M102	R:R:R79	11.17	No	Yes	3	4	6
61	R:R:F232	R:R:R79	4.28	Yes	Yes	3	5	6
62	R:R:I258	R:R:R79	12.53	No	Yes	0	4	6
63	R:R:L80	R:R:L84	4.15	Yes	No	0	7	5
64	R:R:I81	R:R:L98	5.71	No	No	0	5	4
65	R:R:S86	R:R:Y82	3.82	No	No	0	2	3
66	R:R:L85	R:R:S89	3	No	No	0	4	4
67	R:R:I94	R:R:L85	2.85	No	No	0	5	4
68	R:R:I94	R:R:P91	6.77	No	No	0	5	7
69	R:R:K96	R:R:W158	8.12	No	Yes	1	5	4
70	L:L:?1	R:R:K96	17.22	Yes	No	1	0	5
71	R:R:P100	R:R:Y99	5.56	No	Yes	0	4	3
72	R:R:M103	R:R:Y99	7.18	No	Yes	0	2	3
73	R:R:E157	R:R:Y99	10.1	Yes	Yes	1	4	3
74	R:R:F236	R:R:Y99	5.16	Yes	Yes	1	4	3
75	L:L:?1	R:R:Y99	31.69	Yes	Yes	1	0	3
76	R:R:F104	R:R:W147	6.01	Yes	Yes	0	5	9
77	R:R:F104	R:R:S150	7.93	Yes	No	0	5	8
78	R:R:F107	R:R:Y106	5.16	No	Yes	0	6	7
79	R:R:L110	R:R:Y106	5.86	No	Yes	0	7	7
80	R:R:F232	R:R:Y106	8.25	Yes	Yes	3	5	7
81	R:R:G233	R:R:Y106	4.35	No	Yes	0	7	7
82	R:R:S261	R:R:Y106	6.36	No	Yes	3	7	7
83	R:R:F107	R:R:R153	12.83	No	Yes	0	6	4
84	R:R:F107	R:R:W183	4.01	No	Yes	0	6	6
85	R:R:A108	R:R:W147	3.89	No	Yes	0	7	9
86	R:R:A108	R:R:S150	3.42	No	No	0	7	8
87	R:R:F112	R:R:G109	3.01	Yes	No	0	7	9
88	R:R:L146	R:R:S111	6.01	No	No	0	7	6
89	R:R:S111	R:R:W183	3.71	No	Yes	6	6	6
90	R:R:L187	R:R:S111	3	No	No	6	9	6
91	R:R:F112	R:R:L146	6.09	Yes	No	0	7	7
92	R:R:F112	R:R:W147	11.02	Yes	Yes	2	7	9
93	R:R:F225	R:R:L113	3.65	Yes	Yes	2	8	8
94	R:R:L113	R:R:N268	12.36	Yes	Yes	2	8	9
95	R:R:L113	R:R:Y272	3.52	Yes	Yes	2	8	9
96	R:R:L187	R:R:S114	3	No	No	0	9	8
97	R:R:L191	R:R:S117	6.01	No	No	0	8	9
98	R:R:S194	R:R:T118	6.4	No	No	0	8	7
99	R:R:E119	R:R:R134	10.47	No	Yes	0	9	9
100	R:R:R120	R:R:T221	3.88	No	No	0	9	8
101	R:R:C121	R:R:L125	3.17	No	Yes	7	8	7
102	R:R:C121	R:R:S194	3.44	No	No	0	8	8
103	R:R:C121	R:R:V197	3.42	No	No	7	8	4
104	R:R:L122	R:R:W126	4.56	No	No	0	6	6
105	R:R:S123	R:R:Y130	12.72	No	No	0	8	7
106	R:R:L198	R:R:V124	5.96	No	No	0	8	8
107	R:R:I202	R:R:V124	3.07	No	No	0	6	8
108	R:R:L125	R:R:V197	2.98	Yes	No	7	7	4
109	R:R:L125	R:R:R201	6.07	Yes	No	0	7	6
110	R:R:C132	R:R:I128	3.27	No	No	0	6	6
111	R:R:R134	R:R:W129	3	Yes	No	0	9	5
112	R:R:R134	R:R:Y130	7.2	Yes	No	0	9	7
113	R:R:C132	R:R:H133	4.42	No	No	0	6	5
114	R:R:P135	R:R:R134	2.88	No	Yes	5	7	9
115	R:R:L138	R:R:R134	3.64	No	Yes	5	4	9
116	R:R:L138	R:R:P135	6.57	No	No	5	4	7
117	R:R:E157	R:R:R153	11.63	Yes	Yes	1	4	4
118	R:R:R153	R:R:T180	10.35	Yes	No	1	4	5
119	R:R:F237	R:R:R153	4.28	Yes	Yes	1	5	4
120	R:R:L156	R:R:L160	9.69	No	No	1	7	3
121	R:R:L156	R:R:S176	3	No	No	1	7	3
122	R:R:E157	R:R:F237	4.66	Yes	Yes	1	4	5
123	L:L:?1	R:R:E157	11.56	Yes	Yes	1	0	4
124	R:R:G162	R:R:W158	2.81	No	Yes	0	2	4
125	R:R:F163	R:R:W158	7.02	No	Yes	0	4	4
126	L:L:?1	R:R:W158	6.95	Yes	Yes	1	0	4
127	R:R:L164	R:R:M159	5.65	No	No	0	1	4
128	R:R:L160	R:R:W172	4.56	No	No	0	3	1
129	R:R:L160	R:R:S176	3	No	No	1	3	3
130	R:R:C161	R:R:C173	7.28	No	No	1	4	9
131	L:L:?1	R:R:C161	2.77	Yes	No	1	0	4
132	R:R:F165	R:R:L164	7.31	No	No	0	1	1
133	R:R:F165	R:R:W172	9.02	No	No	0	1	1
134	R:R:A171	R:R:W172	3.89	No	No	0	4	1
135	L:L:?1	R:R:C173	5.54	Yes	No	1	0	9
136	R:R:Q174	R:R:W241	15.33	No	No	0	3	3
137	R:R:D177	R:R:F237	8.36	Yes	Yes	1	4	5
138	R:R:D177	R:R:L240	2.71	Yes	Yes	1	4	4
139	R:R:D177	R:R:W241	7.82	Yes	No	1	4	3
140	L:L:?1	R:R:D177	11.84	Yes	Yes	1	0	4
141	R:R:F237	R:R:T180	7.78	Yes	No	1	5	5
142	R:R:F186	R:R:W183	3.01	No	Yes	0	5	6
143	R:R:L187	R:R:W183	12.53	No	Yes	6	9	6
144	R:R:L184	R:R:L230	2.77	No	Yes	2	8	5
145	R:R:I234	R:R:L184	4.28	No	No	2	6	8
146	R:R:F186	R:R:V190	7.87	No	No	0	5	6
147	R:R:C188	R:R:L230	7.94	No	Yes	0	6	5
148	R:R:L191	R:R:V222	2.98	No	No	0	8	8
149	R:R:F225	R:R:L191	17.05	Yes	No	0	8	8
150	R:R:I218	R:R:S195	3.1	Yes	No	0	8	8
151	R:R:S195	R:R:V222	3.23	No	No	0	8	8
152	R:R:I200	R:R:L196	2.85	No	No	0	5	4
153	R:R:I218	R:R:L198	4.28	Yes	No	0	8	8
154	R:R:I218	R:R:L199	5.71	Yes	No	0	8	5
155	R:R:I202	R:R:L211	2.85	No	Yes	8	6	6
156	R:R:I202	R:R:L214	8.56	No	No	8	6	7
157	R:R:L203	R:R:Y215	3.52	No	No	0	5	6
158	R:R:I209	R:R:P210	5.08	No	No	0	4	5
159	R:R:I209	R:R:L211	7.14	No	Yes	0	4	6
160	R:R:L211	R:R:L214	2.77	Yes	No	8	6	7
161	R:R:L211	R:R:Y215	8.21	Yes	No	0	6	6
162	R:R:I218	R:R:L214	2.85	Yes	No	0	8	7
163	R:R:I271	R:R:L220	2.85	No	No	0	8	6
164	R:R:T221	R:R:Y272	3.75	No	Yes	0	8	9
165	R:R:F225	R:R:L226	3.65	Yes	No	2	8	6
166	R:R:F225	R:R:L230	3.65	Yes	Yes	2	8	5
167	R:R:L226	R:R:L230	5.54	No	Yes	2	6	5
168	R:R:C228	R:R:N264	3.15	No	No	0	8	9
169	R:R:G229	R:R:N264	3.39	No	No	0	8	9
170	R:R:I234	R:R:L230	2.85	No	Yes	2	6	5
171	R:R:F232	R:R:S257	3.96	Yes	No	0	5	6
172	R:R:F232	R:R:S261	7.93	Yes	No	3	5	7
173	R:R:I234	R:R:L238	2.85	No	No	0	6	5
174	R:R:F239	R:R:Q235	4.68	No	No	0	4	3
175	R:R:H254	R:R:Q235	9.89	No	No	0	1	3
176	R:R:Q235	R:R:S257	10.11	No	No	0	3	6
177	R:R:F236	R:R:F237	5.36	Yes	Yes	1	4	5
178	R:R:F236	R:R:L240	7.31	Yes	Yes	1	4	4
179	L:L:?1	R:R:F236	3.19	Yes	Yes	1	0	4
180	L:L:?1	R:R:F237	4.25	Yes	Yes	1	0	5
181	R:R:F239	R:R:F250	21.43	No	No	0	4	3
182	R:R:L240	R:R:W241	4.56	Yes	No	1	4	3
183	L:L:?1	R:R:L240	15.69	Yes	Yes	1	0	4
184	R:R:I242	R:R:V244	4.61	No	No	0	1	1
185	R:R:D245	R:R:F250	13.14	No	No	0	3	3
186	R:R:H252	R:R:L249	5.14	No	No	0	1	3
187	R:R:H252	R:R:V253	4.15	No	No	0	1	4
188	R:R:H254	R:R:I258	7.95	No	No	0	1	4
189	R:R:N264	R:R:N268	10.9	No	Yes	0	9	9
190	R:R:F274	R:R:I270	8.79	No	No	0	7	6
191	R:R:F273	R:R:F274	4.29	Yes	No	0	7	7
192	R:R:E247	R:R:L249	2.65	No	No	0	2	3
193	R:R:F104	R:R:S154	2.64	Yes	No	0	5	6
194	R:R:F239	R:R:V253	2.62	No	No	0	4	4
195	R:R:R79	R:R:T34	2.59	Yes	No	0	6	5
196	R:R:F259	R:R:T34	2.59	No	No	0	5	5
197	R:R:R120	R:R:T217	2.59	No	No	0	9	7
198	R:R:S95	R:R:Y82	2.54	No	No	0	7	3
199	R:R:F87	R:R:I88	2.51	Yes	No	0	4	3
200	R:R:F87	R:R:L84	2.44	Yes	No	0	4	5
201	R:R:F104	R:R:L151	2.44	Yes	No	0	5	4
202	R:R:F259	R:R:L263	2.44	No	No	0	5	5
203	R:R:I271	R:R:Y272	2.42	No	Yes	0	8	9
204	R:R:L85	R:R:Y82	2.34	No	No	0	4	3
205	R:R:G229	R:R:P231	2.03	No	No	0	8	9
206	R:R:C192	R:R:G193	1.96	No	No	0	5	4
207	R:R:G78	R:R:S77	1.86	No	No	0	5	5
208	R:R:G167	R:R:S170	1.86	No	No	0	1	3
209	R:R:G41	R:R:V40	1.84	No	No	0	9	6
210	R:R:G44	R:R:V47	1.84	No	No	0	8	6
211	R:R:G276	R:R:V275	1.84	No	No	0	8	8
212	R:R:G44	R:R:T43	1.82	No	No	0	8	5
213	R:R:C188	R:R:C192	1.82	No	No	0	6	5
214	R:R:P269	R:R:V48	1.77	No	No	0	9	9
215	R:R:G78	R:R:M102	1.75	No	No	0	5	4
216	R:R:G41	R:R:L76	1.71	No	Yes	0	9	7
217	R:R:A171	R:R:S170	1.71	No	No	0	4	3
218	R:R:G193	R:R:L196	1.71	No	No	0	4	4
219	R:R:A262	R:R:V37	1.7	No	No	0	6	7
220	R:R:A69	R:R:V48	1.7	No	No	0	9	9
221	R:R:L260	R:R:P231	1.64	No	No	0	7	9
222	R:R:S194	R:R:V190	1.62	No	No	0	8	6
223	R:R:A267	R:R:I270	1.62	No	No	0	7	6
224	R:R:T31	R:R:V32	1.59	No	No	0	4	6
225	R:R:T217	R:R:V216	1.59	No	No	0	7	7
226	R:R:A69	R:R:L49	1.58	No	No	0	9	7
227	R:R:I36	R:R:V32	1.54	No	No	0	5	6
228	R:R:A168	R:R:D169	1.54	No	No	0	2	3
229	R:R:I185	R:R:V181	1.54	No	No	0	5	5
230	R:R:K208	R:R:S206	1.53	No	No	0	5	6
231	R:R:I179	R:R:T175	1.52	No	No	0	5	4
232	R:R:N59	R:R:S62	1.49	No	No	0	8	7
233	R:R:L74	R:R:V101	1.49	No	No	0	7	6
234	R:R:L238	R:R:V181	1.49	No	No	0	5	5
235	R:R:L220	R:R:V224	1.49	No	No	0	6	7
236	R:R:L249	R:R:V248	1.49	No	No	0	3	1
237	R:R:D169	R:R:S170	1.47	No	No	0	3	3
238	R:R:D177	R:R:S176	1.47	Yes	No	1	4	3
239	R:R:I94	R:R:L98	1.43	No	No	0	5	4
240	R:R:I155	R:R:L151	1.43	No	No	0	4	4
241	R:R:A46	R:R:F73	1.39	No	No	0	6	7
242	R:R:H92	R:R:S95	1.39	No	No	0	1	7
243	R:R:L255	R:R:L30	1.38	No	No	0	2	5
244	R:R:L226	R:R:L227	1.38	No	No	0	6	5
245	R:R:P127	R:R:W126	1.35	No	No	0	9	6
246	R:R:F186	R:R:V189	1.31	No	No	0	5	4
247	R:R:R246	R:R:V244	1.31	No	No	0	2	1
248	R:R:R213	R:R:T217	1.29	No	No	0	7	7
249	R:R:H254	R:R:L255	1.29	No	No	0	1	2
250	R:R:F178	R:R:I179	1.26	No	No	0	3	5
251	R:R:F259	R:R:L33	1.22	No	No	0	5	6
252	R:R:L211	R:R:R207	1.21	Yes	No	0	6	4
253	R:R:L125	R:R:W126	1.14	Yes	No	0	7	6
254	R:R:R55	R:R:R58	1.07	No	No	0	6	7
255	R:R:F278	R:R:R213	1.07	No	No	0	5	7
256	R:R:H133	R:R:W129	1.06	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L42	3.6975	4	4	7
2	R:R:Y64	5.70833	6	0	7
3	R:R:L68	6.0575	4	2	9
4	R:R:D72	6.195	4	2	9
5	R:R:F75	6.32	5	3	6
6	R:R:L76	3.715	4	4	7
7	R:R:R79	7.396	5	3	6
8	R:R:L80	4.645	4	4	7
9	R:R:F87	2.9075	4	0	4
10	R:R:Y99	11.938	5	1	3
11	R:R:F104	4.755	4	0	5
12	R:R:Y106	6.37167	6	3	7
13	R:R:F112	5.43	6	2	7
14	R:R:L113	6.2675	4	2	8
15	R:R:L125	3.34	4	7	7
16	R:R:R134	5.22333	6	5	9
17	R:R:W147	5.64	5	2	9
18	R:R:R153	9.7725	4	1	4
19	R:R:E157	9.4875	4	1	4
20	R:R:W158	6.225	4	1	4
21	R:R:D177	6.44	5	1	4
22	R:R:W183	5.815	4	6	6
23	R:R:L211	4.436	5	8	6
24	R:R:I218	3.985	4	0	8
25	R:R:F225	7	4	2	8
26	R:R:L230	4.55	5	2	5
27	R:R:F232	6.105	4	3	5
28	R:R:F236	5.255	4	1	4
29	R:R:F237	5.78167	6	1	5
30	R:R:L240	7.5675	4	1	4
31	R:R:N268	10.5725	4	2	9
32	R:R:Y272	4.384	5	2	9
33	R:R:F273	6.9725	4	0	7
34	L:L:?1	11.07	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F87	R:R:T31	14.3365	3.89	Yes	No	0	4	4
2	R:R:F87	R:R:L84	26.0485	2.44	Yes	No	0	4	5
3	R:R:L80	R:R:L84	28.9486	4.15	Yes	No	0	7	5
4	R:R:L80	R:R:S38	17.2949	7.51	Yes	No	4	7	5
5	R:R:L76	R:R:S38	18.6894	4.5	Yes	No	4	7	5
6	R:R:L76	R:R:S265	47.9667	4.5	Yes	No	0	7	9
7	R:R:F75	R:R:S265	95.101	7.93	Yes	No	0	6	9
8	R:R:F75	R:R:R79	32.5699	6.41	Yes	Yes	3	6	6
9	R:R:I258	R:R:R79	17.226	12.53	No	Yes	0	4	6
10	R:R:H254	R:R:I258	15.7415	7.95	No	No	0	1	4
11	R:R:L42	R:R:L80	17.4169	2.77	Yes	Yes	4	7	7
12	R:R:L42	R:R:L76	21.6054	4.15	Yes	Yes	4	7	7
13	R:R:D72	R:R:S265	100	5.89	Yes	No	0	9	9
14	R:R:D72	R:R:N45	32.7289	4.04	Yes	No	0	9	9
15	R:R:N45	R:R:P269	31.2762	11.4	No	No	0	9	9
16	R:R:P269	R:R:V48	29.8128	1.77	No	No	0	9	9
17	R:R:F273	R:R:V48	23.8535	6.55	Yes	No	0	7	9
18	R:R:C143	R:R:Y64	22.8408	2.69	No	Yes	0	7	7
19	R:R:C143	R:R:N67	24.1133	6.3	No	No	0	7	9
20	R:R:F112	R:R:N67	24.4685	6.04	Yes	No	2	7	9
21	R:R:F112	R:R:L68	42.9193	3.65	Yes	Yes	2	7	9
22	R:R:D72	R:R:L68	57.7329	5.43	Yes	Yes	2	9	9
23	R:R:E119	R:R:Y64	13.4457	12.35	No	Yes	0	9	7
24	R:R:E119	R:R:R134	12.3005	10.47	No	Yes	0	9	9
25	R:R:L113	R:R:Y272	27.2785	3.52	Yes	Yes	2	8	9
26	R:R:L113	R:R:L68	55.1986	5.54	Yes	Yes	2	8	9
27	R:R:L113	R:R:N268	36.9599	12.36	Yes	Yes	2	8	9
28	R:R:D72	R:R:N268	40.7455	9.42	Yes	Yes	2	9	9
29	R:R:F112	R:R:W147	10.4289	11.02	Yes	Yes	2	7	9
30	R:R:F75	R:R:M102	16.8867	3.73	Yes	No	3	6	4
31	R:R:F75	R:R:Y106	59.5674	8.25	Yes	Yes	3	6	7
32	R:R:I81	R:R:S77	14.7447	3.1	No	No	0	5	5
33	R:R:G78	R:R:S77	16.1868	1.86	No	No	0	5	5
34	R:R:G78	R:R:M102	17.6184	1.75	No	No	0	5	4
35	R:R:F232	R:R:R79	14.9462	4.28	Yes	Yes	3	5	6
36	R:R:F232	R:R:Y106	19.983	8.25	Yes	Yes	3	5	7
37	R:R:I81	R:R:L98	13.2867	5.71	No	No	0	5	4
38	R:R:I94	R:R:L98	12.0778	1.43	No	No	0	5	4
39	L:L:?1	R:R:E157	11.8233	11.56	Yes	Yes	1	0	4
40	R:R:E157	R:R:R153	17.8729	11.63	Yes	Yes	1	4	4
41	R:R:F107	R:R:R153	61.9744	12.83	No	Yes	0	6	4
42	R:R:F107	R:R:Y106	55.9567	5.16	No	Yes	0	6	7
43	L:L:?1	R:R:F237	11.5052	4.25	Yes	Yes	1	0	5
44	R:R:F237	R:R:R153	41.546	4.28	Yes	Yes	1	5	4
45	R:R:F107	R:R:W183	31.2762	4.01	No	Yes	0	6	6
46	R:R:F112	R:R:L146	27.7292	6.09	Yes	No	0	7	7
47	R:R:L146	R:R:S111	27.4694	6.01	No	No	0	7	6
48	R:R:S111	R:R:W183	26.4302	3.71	No	Yes	6	6	6
49	R:R:F225	R:R:L113	66.5659	3.65	Yes	Yes	2	8	8
50	R:R:F225	R:R:L191	35.6132	17.05	Yes	No	0	8	8
51	R:R:F186	R:R:W183	16.6057	3.01	No	Yes	0	5	6
52	R:R:F186	R:R:V190	13.9123	7.87	No	No	0	5	6
53	R:R:S194	R:R:V190	12.5497	1.62	No	No	0	8	6
54	R:R:T221	R:R:Y272	13.7426	3.75	No	Yes	0	8	9
55	R:R:R120	R:R:T221	11.3462	3.88	No	No	0	9	8
56	R:R:I218	R:R:S195	26.3242	3.1	Yes	No	0	8	8
57	R:R:S195	R:R:V222	28.6782	3.23	No	No	0	8	8
58	R:R:L191	R:R:V222	31.0217	2.98	No	No	0	8	8
59	R:R:I218	R:R:L214	17.629	2.85	Yes	No	0	8	7
60	R:R:D177	R:R:S176	20.4178	1.47	Yes	No	1	4	3
61	R:R:D177	R:R:F237	25.8364	8.36	Yes	Yes	1	4	5
62	R:R:L160	R:R:S176	17.12	3	No	No	1	3	3
63	R:R:L160	R:R:W172	15.5029	4.56	No	No	0	3	1
64	R:R:F225	R:R:L230	26.2393	3.65	Yes	Yes	2	8	5
65	R:R:C188	R:R:L230	12.1362	7.94	No	Yes	0	6	5
66	R:R:L211	R:R:L214	13.2549	2.77	Yes	No	8	6	7
67	R:R:F232	R:R:S257	25.6826	3.96	Yes	No	0	5	6
68	R:R:F239	R:R:Q235	27.9678	4.68	No	No	0	4	3
69	R:R:H254	R:R:Q235	10.6887	9.89	No	No	0	1	3
70	R:R:Q235	R:R:S257	23.1748	10.11	No	No	0	3	6
71	R:R:H252	R:R:V253	14.7341	4.15	No	No	0	1	4
72	R:R:F239	R:R:V253	18.0372	2.62	No	No	0	4	4
73	R:R:H252	R:R:L249	11.0652	5.14	No	No	0	1	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K96	R:R:W158	8.12	1	No	Yes	5	4	1	1
L:L:?1	R:R:K96	17.22	1	Yes	No	0	5	0	1
R:R:P100	R:R:Y99	5.56	0	No	Yes	4	3	2	1
R:R:M103	R:R:Y99	7.18	0	No	Yes	2	3	2	1
R:R:E157	R:R:Y99	10.1	1	Yes	Yes	4	3	1	1
R:R:F236	R:R:Y99	5.16	1	Yes	Yes	4	3	1	1
L:L:?1	R:R:Y99	31.69	1	Yes	Yes	0	3	0	1
R:R:E157	R:R:R153	11.63	1	Yes	Yes	4	4	1	2
R:R:R153	R:R:T180	10.35	1	Yes	No	4	5	2	2
R:R:F237	R:R:R153	4.28	1	Yes	Yes	5	4	1	2
R:R:E157	R:R:F237	4.66	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:E157	11.56	1	Yes	Yes	0	4	0	1
R:R:G162	R:R:W158	2.81	0	No	Yes	2	4	2	1
R:R:F163	R:R:W158	7.02	0	No	Yes	4	4	2	1
L:L:?1	R:R:W158	6.95	1	Yes	Yes	0	4	0	1
R:R:C161	R:R:C173	7.28	1	No	No	4	9	1	1
L:L:?1	R:R:C161	2.77	1	Yes	No	0	4	0	1
L:L:?1	R:R:C173	5.54	1	Yes	No	0	9	0	1
R:R:D177	R:R:F237	8.36	1	Yes	Yes	4	5	1	1
R:R:D177	R:R:L240	2.71	1	Yes	Yes	4	4	1	1
R:R:D177	R:R:W241	7.82	1	Yes	No	4	3	1	2
L:L:?1	R:R:D177	11.84	1	Yes	Yes	0	4	0	1
R:R:F237	R:R:T180	7.78	1	Yes	No	5	5	1	2
R:R:F236	R:R:F237	5.36	1	Yes	Yes	4	5	1	1
R:R:F236	R:R:L240	7.31	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:F236	3.19	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F237	4.25	1	Yes	Yes	0	5	0	1
R:R:L240	R:R:W241	4.56	1	Yes	No	4	3	1	2
L:L:?1	R:R:L240	15.69	1	Yes	Yes	0	4	0	1
R:R:D177	R:R:S176	1.47	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HJ5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.69
Number of Linked Nodes	228
Number of Links	256
Number of Hubs	34
Number of Links mediated by Hubs	127
Number of Communities	8
Number of Nodes involved in Communities	55
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	40039
Length Of Smallest Path	3
Average Path Length	12.8417
Length of Longest Path	26
Minimum Path Strength	1.18
Average Path Strength	5.72815
Maximum Path Strength	18.6967
Minimum Path Correlation	0.7
Average Path Correlation	0.918286
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	47.5432
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.5894
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U2U
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U2U
Name	N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide
Synonyms
Identifier
Formula	C23 H21 N3 O4 S
Molecular Weight	435.496
SMILES
PubChem	139030531
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8HJ5_nogp_Chain_R Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I S P H T I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G F L F S G A D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C G S R K I P L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JGF	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGF (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/β1/γ2	3	2024-01-10	10.1038/s41467-023-40705-z
	8JGG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		3	2024-01-10	10.1038/s41467-023-40705-z
	8JGB	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/β1/γ2	2.84	2024-01-10	10.1038/s41467-023-40705-z
	8JGB (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-		2.84	2024-01-10	10.1038/s41467-023-40705-z
	8HJ5	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-05-31	10.1371/journal.pbio.3001975
	8HJ5 (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3	2023-05-31	10.1371/journal.pbio.3001975
	8DWH	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWH (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382		2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWC	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2022-11-02	10.1038/s41589-022-01173-6
	8DWC (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-		2.87	2022-11-02	10.1038/s41589-022-01173-6

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Download 8HJ5_nogp.zip

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