psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G9	R:R:S170	3.71	No	No	0	0	3
2	L:L:R10	L:L:W14	5	No	Yes	0	0	0
3	L:L:P11	L:L:W13	14.86	No	No	1	0	0
4	L:L:P11	L:L:W14	13.51	No	Yes	1	0	0
5	L:L:P11	R:R:W241	5.4	No	Yes	1	0	3
6	L:L:W13	L:L:W14	7.5	No	Yes	1	0	0
7	L:L:W13	R:R:H243	23.27	No	No	0	0	1
8	L:L:Q18	L:L:W14	13.14	No	Yes	0	0	0
9	L:L:K19	L:L:W14	5.8	No	Yes	0	0	0
10	L:L:W14	R:R:W241	4.69	Yes	Yes	1	0	3
11	L:L:M15	L:L:Y17	11.97	No	Yes	1	0	0
12	L:L:M15	R:R:R246	8.69	No	No	0	0	2
13	L:L:M15	R:R:F250	7.46	No	Yes	1	0	3
14	L:L:Q18	L:L:Y17	13.53	No	Yes	0	0	0
15	L:L:Y17	R:R:F250	10.32	Yes	Yes	1	0	3
16	L:L:Y17	R:R:H254	14.16	Yes	Yes	1	0	1
17	L:L:Y17	W:W:?1	3.91	Yes	Yes	1	0	0
18	L:L:Q18	R:R:L240	6.65	No	No	0	0	4
19	L:L:R20	R:R:Y99	18.52	Yes	Yes	1	0	3
20	L:L:R20	R:R:E157	8.14	Yes	Yes	1	0	4
21	L:L:R20	R:R:C161	5.57	Yes	No	0	0	4
22	L:L:R20	R:R:D177	4.76	Yes	Yes	1	0	4
23	L:L:R20	R:R:F236	4.28	Yes	Yes	1	0	4
24	L:L:R20	R:R:L240	6.07	Yes	No	1	0	4
25	L:L:Y21	R:R:Y99	6.95	Yes	Yes	1	0	3
26	L:L:Y21	R:R:P100	5.56	Yes	No	1	0	4
27	L:L:Y21	R:R:W158	4.82	Yes	No	0	0	4
28	L:L:Y21	R:R:G162	4.35	Yes	No	0	0	2
29	R:R:C23	R:R:T27	5.07	No	No	0	2	4
30	R:R:C23	R:R:C251	7.28	No	No	0	2	1
31	R:R:L28	R:R:Y24	10.55	No	No	0	4	3
32	R:R:C251	R:R:Q26	6.1	No	No	0	1	1
33	R:R:H252	R:R:Q26	8.65	No	No	0	1	1
34	R:R:L255	R:R:L30	4.15	No	No	0	2	5
35	R:R:F259	R:R:L30	3.65	No	No	0	5	5
36	R:R:S86	R:R:T31	6.4	No	Yes	0	2	4
37	R:R:F259	R:R:L33	10.96	No	No	0	5	6
38	R:R:F259	R:R:V37	5.24	No	No	0	5	7
39	R:R:S266	R:R:V37	4.85	No	No	0	7	7
40	R:R:L80	R:R:S38	4.5	No	No	0	7	5
41	R:R:L39	R:R:L80	4.15	No	No	0	5	7
42	R:R:G41	R:R:S266	3.71	No	No	0	9	7
43	R:R:F73	R:R:L42	4.87	No	No	0	7	7
44	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
45	R:R:N45	R:R:P269	8.15	No	No	0	9	9
46	R:R:F274	R:R:V47	3.93	Yes	No	0	7	6
47	R:R:F273	R:R:V48	9.18	Yes	No	3	7	9
48	R:R:F274	R:R:V48	3.93	Yes	No	3	7	9
49	R:R:F73	R:R:L49	3.65	No	No	0	7	7
50	R:R:F273	R:R:L51	4.87	Yes	No	0	7	7
51	R:R:L52	R:R:S62	4.5	Yes	No	0	7	7
52	R:R:L52	R:R:L66	5.54	Yes	No	0	7	7
53	R:R:F273	R:R:L52	8.53	Yes	Yes	0	7	7
54	R:R:N59	R:R:S62	7.45	No	No	0	8	7
55	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
56	R:R:F61	R:R:I65	8.79	No	No	0	7	8
57	R:R:F61	R:R:V116	7.87	No	No	0	7	8
58	R:R:I63	R:R:S139	10.84	No	No	0	7	9
59	R:R:A115	R:R:Y64	4	No	Yes	0	7	7
60	R:R:E119	R:R:Y64	16.83	No	Yes	0	9	7
61	R:R:S139	R:R:Y64	5.09	No	Yes	0	9	7
62	R:R:V142	R:R:Y64	6.31	No	Yes	0	6	7
63	R:R:C143	R:R:Y64	4.03	No	Yes	0	7	7
64	R:R:I65	R:R:Y272	4.84	No	Yes	0	8	9
65	R:R:F112	R:R:N67	10.87	Yes	No	2	7	9
66	R:R:C143	R:R:N67	12.6	No	No	2	7	9
67	R:R:N67	R:R:W147	6.78	No	Yes	2	9	9
68	R:R:D72	R:R:L68	5.43	Yes	No	2	9	9
69	R:R:F112	R:R:L68	3.65	Yes	No	2	7	9
70	R:R:L68	R:R:N268	6.87	No	Yes	2	9	9
71	R:R:A71	R:R:W147	3.89	No	Yes	0	9	9
72	R:R:D72	R:R:S265	10.31	Yes	No	0	9	9
73	R:R:D72	R:R:N268	6.73	Yes	Yes	2	9	9
74	R:R:L74	R:R:S105	4.5	No	No	0	7	8
75	R:R:F75	R:R:R79	16.03	Yes	Yes	1	6	6
76	R:R:F75	R:R:M102	4.98	Yes	No	1	6	4
77	R:R:F75	R:R:S105	5.28	Yes	No	0	6	8
78	R:R:F75	R:R:Y106	7.22	Yes	Yes	0	6	7
79	R:R:F75	R:R:S261	3.96	Yes	No	0	6	7
80	R:R:F75	R:R:S265	6.61	Yes	No	0	6	9
81	R:R:L76	R:R:S265	4.5	No	No	0	7	9
82	R:R:L76	R:R:S266	4.5	No	No	0	7	7
83	R:R:G78	R:R:S77	3.71	No	No	0	5	5
84	R:R:M102	R:R:R79	7.44	No	Yes	1	4	6
85	R:R:F232	R:R:R79	10.69	Yes	Yes	1	5	6
86	R:R:I258	R:R:R79	13.78	No	Yes	1	4	6
87	R:R:R79	W:W:?1	12.17	Yes	Yes	1	6	0
88	R:R:I81	R:R:L98	4.28	No	Yes	0	5	4
89	R:R:S95	R:R:Y82	7.63	No	No	0	7	3
90	R:R:Y82	W:W:?1	43.84	No	Yes	0	3	0
91	R:R:I90	R:R:L85	17.13	No	No	0	5	4
92	R:R:I94	R:R:L85	7.14	No	No	0	5	4
93	R:R:I90	R:R:P91	10.16	No	No	0	5	7
94	R:R:I94	R:R:S95	4.64	No	No	0	5	7
95	R:R:P100	R:R:Y99	8.34	No	Yes	1	4	3
96	R:R:M103	R:R:Y99	5.99	Yes	Yes	1	2	3
97	R:R:E157	R:R:Y99	6.73	Yes	Yes	1	4	3
98	R:R:F236	R:R:Y99	6.19	Yes	Yes	1	4	3
99	R:R:M102	W:W:?1	15.11	No	Yes	1	4	0
100	R:R:F232	R:R:M103	3.73	Yes	Yes	1	5	2
101	R:R:F236	R:R:M103	3.73	Yes	Yes	1	4	2
102	R:R:F237	R:R:M103	4.98	Yes	Yes	1	5	2
103	R:R:F104	R:R:W147	6.01	Yes	Yes	0	5	9
104	R:R:F104	R:R:S150	7.93	Yes	No	0	5	8
105	R:R:F104	R:R:L151	3.65	Yes	No	0	5	4
106	R:R:F107	R:R:Y106	5.16	Yes	Yes	0	6	7
107	R:R:L110	R:R:Y106	9.38	No	Yes	0	7	7
108	R:R:F232	R:R:Y106	6.19	Yes	Yes	0	5	7
109	R:R:G233	R:R:Y106	4.35	No	Yes	0	7	7
110	R:R:F107	R:R:R153	14.97	Yes	Yes	1	6	4
111	R:R:F107	R:R:T180	3.89	Yes	No	1	6	5
112	R:R:F107	R:R:L184	7.31	Yes	No	0	6	8
113	R:R:A108	R:R:W147	5.19	No	Yes	0	7	9
114	R:R:F225	R:R:L110	4.87	Yes	No	0	8	7
115	R:R:L146	R:R:S111	12.01	No	No	0	7	6
116	R:R:C143	R:R:F112	6.98	No	Yes	2	7	7
117	R:R:F112	R:R:L146	7.31	Yes	No	0	7	7
118	R:R:F112	R:R:W147	9.02	Yes	Yes	2	7	9
119	R:R:F225	R:R:L113	6.09	Yes	No	0	8	8
120	R:R:L113	R:R:N268	6.87	No	Yes	2	8	9
121	R:R:L113	R:R:Y272	4.69	No	Yes	2	8	9
122	R:R:L187	R:R:S114	6.01	No	No	0	9	8
123	R:R:R120	R:R:S117	5.27	Yes	No	0	9	9
124	R:R:L191	R:R:S117	6.01	No	No	0	8	9
125	R:R:S194	R:R:T118	6.4	No	No	0	8	7
126	R:R:E119	R:R:R134	11.63	No	Yes	0	9	9
127	R:R:L198	R:R:R120	4.86	No	Yes	4	8	9
128	R:R:I218	R:R:R120	6.26	No	Yes	4	8	9
129	R:R:R120	R:R:T221	7.76	Yes	No	0	9	8
130	R:R:C121	R:R:L125	4.76	No	No	0	8	7
131	R:R:S123	R:R:Y130	17.8	No	No	0	8	7
132	R:R:L125	R:R:W126	12.53	No	No	0	7	6
133	R:R:L125	R:R:V197	4.47	No	No	0	7	4
134	R:R:H133	R:R:W129	4.23	No	No	0	5	5
135	R:R:R134	R:R:W129	8	Yes	No	0	9	5
136	R:R:R134	R:R:Y130	8.23	Yes	No	0	9	7
137	R:R:C132	R:R:H133	4.42	No	No	0	6	5
138	R:R:L138	R:R:R134	10.93	No	Yes	0	4	9
139	R:R:H137	R:R:T136	8.21	No	No	0	6	4
140	R:R:E157	R:R:R153	5.82	Yes	Yes	1	4	4
141	R:R:R153	R:R:T180	9.06	Yes	No	1	4	5
142	R:R:L156	R:R:L160	4.15	No	No	1	7	3
143	R:R:E157	R:R:F237	5.83	Yes	Yes	1	4	5
144	R:R:F163	R:R:W158	5.01	No	No	0	4	4
145	R:R:L160	R:R:W172	6.83	No	No	0	3	1
146	R:R:C161	R:R:C173	7.28	No	No	0	4	9
147	R:R:F165	R:R:W172	5.01	No	No	0	1	1
148	R:R:G167	R:R:S166	3.71	No	No	0	1	1
149	R:R:S170	R:R:W241	4.94	No	Yes	0	3	3
150	R:R:C173	R:R:D177	4.67	No	Yes	1	9	4
151	R:R:C173	R:R:W241	6.53	No	Yes	1	9	3
152	R:R:Q174	R:R:W241	25.19	No	Yes	0	3	3
153	R:R:D177	R:R:L240	6.79	Yes	No	1	4	4
154	R:R:D177	R:R:W241	13.4	Yes	Yes	1	4	3
155	R:R:F237	R:R:T180	15.56	Yes	No	1	5	5
156	R:R:L238	R:R:V181	5.96	No	No	0	5	5
157	R:R:F186	R:R:W183	5.01	No	Yes	0	5	6
158	R:R:L187	R:R:W183	7.97	No	Yes	0	9	6
159	R:R:I234	R:R:L184	7.14	No	No	0	6	8
160	R:R:F186	R:R:V190	6.55	No	No	0	5	6
161	R:R:F225	R:R:L191	7.31	Yes	No	0	8	8
162	R:R:L198	R:R:L214	4.15	No	No	0	8	7
163	R:R:I218	R:R:L198	4.28	No	No	4	8	8
164	R:R:L199	R:R:Y215	5.86	No	No	0	5	6
165	R:R:I218	R:R:L199	4.28	No	No	0	8	5
166	R:R:I202	R:R:L214	7.14	No	No	0	6	7
167	R:R:L203	R:R:Y215	7.03	No	No	0	5	6
168	R:R:R213	R:R:V275	3.92	No	No	0	7	8
169	R:R:I271	R:R:L220	5.71	Yes	No	0	8	6
170	R:R:T221	R:R:Y272	7.49	No	Yes	0	8	9
171	R:R:N264	R:R:V224	4.43	Yes	No	0	9	7
172	R:R:I271	R:R:V224	4.61	Yes	No	0	8	7
173	R:R:F225	R:R:L230	9.74	Yes	No	0	8	5
174	R:R:G229	R:R:N264	5.09	No	Yes	0	8	9
175	R:R:F232	R:R:Q235	4.68	Yes	Yes	1	5	3
176	R:R:F232	R:R:S257	3.96	Yes	No	1	5	6
177	R:R:F232	R:R:S261	6.61	Yes	No	0	5	7
178	R:R:Q235	R:R:V253	5.73	Yes	No	0	3	4
179	R:R:H254	R:R:Q235	9.89	Yes	Yes	1	1	3
180	R:R:Q235	R:R:S257	10.11	Yes	No	1	3	6
181	R:R:F236	R:R:F237	9.65	Yes	Yes	1	4	5
182	R:R:F236	W:W:?1	5.69	Yes	Yes	1	4	0
183	R:R:F239	R:R:V244	3.93	No	No	1	4	1
184	R:R:F239	R:R:L249	7.31	No	No	1	4	3
185	R:R:L249	R:R:V244	4.47	No	No	1	3	1
186	R:R:D245	R:R:E247	3.9	No	No	0	3	2
187	R:R:D245	R:R:V248	8.76	No	No	0	3	1
188	R:R:C251	R:R:E247	4.56	No	No	0	1	2
189	R:R:F250	R:R:H254	4.53	Yes	Yes	1	3	1
190	R:R:F250	R:R:L255	6.09	Yes	No	0	3	2
191	R:R:H254	R:R:I258	7.95	Yes	No	1	1	4
192	R:R:H254	W:W:?1	10.3	Yes	Yes	1	1	0
193	R:R:I258	W:W:?1	16.2	No	Yes	1	4	0
194	R:R:N264	R:R:N268	8.17	Yes	Yes	0	9	9
195	R:R:N268	R:R:Y272	6.98	Yes	Yes	2	9	9
196	R:R:I271	R:R:Y272	7.25	Yes	Yes	0	8	9
197	R:R:F273	R:R:F274	6.43	Yes	Yes	3	7	7
198	R:R:C35	R:R:S83	3.44	No	No	0	5	6
199	R:R:L122	R:R:W126	3.42	No	No	0	6	6
200	R:R:L122	R:R:W129	3.42	No	No	0	6	5
201	R:R:L164	R:R:W158	3.42	No	No	0	1	4
202	R:R:A69	R:R:V48	3.39	No	No	0	9	9
203	R:R:L138	R:R:P135	3.28	No	No	0	4	7
204	R:R:C132	R:R:I128	3.27	No	No	0	6	6
205	R:R:S117	R:R:S195	3.26	No	No	0	9	8
206	R:R:S195	R:R:V222	3.23	No	No	0	8	8
207	R:R:S83	R:R:T31	3.2	No	Yes	0	6	4
208	R:R:S83	R:R:T34	3.2	No	No	0	6	5
209	R:R:C188	R:R:L230	3.17	No	No	0	6	5
210	R:R:C228	R:R:L260	3.17	No	No	0	8	7
211	R:R:A69	R:R:L49	3.15	No	No	0	9	7
212	R:R:C228	R:R:N264	3.15	No	Yes	0	8	9
213	R:R:I202	R:R:V124	3.07	No	No	0	6	8
214	R:R:F107	R:R:W183	3.01	Yes	Yes	0	6	6
215	R:R:L30	R:R:S29	3	No	No	0	5	4
216	R:R:L76	R:R:S38	3	No	No	0	7	5
217	R:R:L226	R:R:V222	2.98	No	No	0	6	8
218	R:R:L260	R:R:V256	2.98	No	No	0	7	4
219	R:R:T31	W:W:?1	2.95	Yes	Yes	0	4	0
220	R:R:I155	R:R:M159	2.92	No	No	0	4	4
221	R:R:F274	R:R:P269	2.89	Yes	No	0	7	9
222	R:R:E157	R:R:S176	2.87	Yes	No	1	4	3
223	R:R:I94	R:R:L98	2.85	No	Yes	0	5	4
224	R:R:I200	R:R:L196	2.85	No	No	0	5	4
225	R:R:I202	R:R:L211	2.85	No	No	0	6	6
226	R:R:I234	R:R:L238	2.85	No	No	0	6	5
227	R:R:C23	R:R:F250	2.79	No	Yes	0	2	3
228	R:R:L80	R:R:L84	2.77	No	No	0	7	5
229	R:R:A168	R:R:F165	2.77	No	No	0	2	1
230	R:R:L226	R:R:L227	2.77	No	No	0	6	5
231	R:R:F104	R:R:S154	2.64	Yes	No	0	5	6
232	R:R:R153	R:R:S154	2.64	Yes	No	0	4	6
233	R:R:R201	R:R:V124	2.62	No	No	0	6	8
234	R:R:L52	R:R:R55	2.43	Yes	No	0	7	6
235	R:R:L66	R:R:R58	2.43	No	No	0	7	7
236	L:L:Y17	R:R:L249	2.34	Yes	No	1	0	3
237	R:R:F239	R:R:Q235	2.34	No	Yes	1	4	3
238	R:R:L149	R:R:W183	2.28	No	Yes	0	6	6
239	R:R:G229	R:R:P231	2.03	No	No	0	8	9
240	R:R:A71	R:R:G109	1.95	No	No	0	9	9
241	R:R:G41	R:R:V40	1.84	No	No	0	9	6
242	R:R:G44	R:R:V47	1.84	No	No	0	8	6
243	R:R:G44	R:R:T43	1.82	No	No	0	8	5
244	R:R:C188	R:R:C192	1.82	No	No	0	6	5
245	R:R:C121	R:R:S194	1.72	No	No	0	8	8
246	R:R:A262	R:R:S38	1.71	No	No	0	6	5
247	R:R:G78	R:R:L98	1.71	No	Yes	0	5	4
248	R:R:G193	R:R:L196	1.71	No	No	0	4	4
249	R:R:A267	R:R:I271	1.62	No	Yes	0	7	8
250	R:R:T31	R:R:V32	1.59	Yes	No	0	4	6
251	R:R:T212	R:R:V216	1.59	No	No	0	5	7
252	R:R:C228	R:R:L263	1.59	No	No	0	8	5
253	R:R:A70	R:R:L49	1.58	No	No	0	6	7
254	R:R:T217	R:R:T221	1.57	No	No	0	7	8
255	R:R:I36	R:R:V32	1.54	No	No	0	5	6
256	R:R:A171	R:R:D169	1.54	No	No	0	4	3
257	R:R:I185	R:R:V181	1.54	No	No	0	5	5
258	R:R:I185	R:R:V189	1.54	No	No	0	5	4
259	R:R:I242	R:R:V244	1.54	No	No	0	1	1
260	R:R:G53	R:R:R58	1.5	No	No	0	5	7
261	R:R:L156	R:R:S176	1.5	No	No	1	7	3
262	R:R:L160	R:R:S176	1.5	No	No	1	3	3
263	R:R:L223	R:R:V222	1.49	No	No	0	6	8
264	R:R:I88	R:R:I90	1.47	No	No	0	3	5
265	R:R:D169	R:R:S170	1.47	No	No	0	3	3
266	R:R:I97	R:R:L98	1.43	No	Yes	0	4	4
267	R:R:I155	R:R:L151	1.43	No	No	0	4	4
268	R:R:I179	R:R:L156	1.43	No	No	0	5	7
269	R:R:L149	R:R:L152	1.38	No	No	0	6	4
270	R:R:P127	R:R:W126	1.35	No	No	0	9	6
271	R:R:F274	R:R:I270	1.26	Yes	No	0	7	6
272	R:R:F163	R:R:K96	1.24	No	No	0	4	5
273	R:R:F87	R:R:L28	1.22	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W14	8.27333	6	1	0
2	L:L:Y17	9.37167	6	1	0
3	L:L:R20	7.89	6	1	0
4	L:L:Y21	5.42	4	1	0
5	R:R:T31	3.535	4	0	4
6	R:R:L52	5.25	4	0	7
7	R:R:Y64	7.252	5	0	7
8	R:R:D72	7.3	4	2	9
9	R:R:F75	7.34667	6	1	6
10	R:R:R79	12.022	5	1	6
11	R:R:L98	2.5675	4	0	4
12	R:R:Y99	8.78667	6	1	3
13	R:R:M103	4.6075	4	1	2
14	R:R:F104	5.0575	4	0	5
15	R:R:Y106	6.46	5	0	7
16	R:R:F107	6.868	5	1	6
17	R:R:F112	7.566	5	2	7
18	R:R:R120	6.0375	4	4	9
19	R:R:R134	8.588	5	0	9
20	R:R:W147	6.178	5	2	9
21	R:R:R153	8.1225	4	1	4
22	R:R:E157	5.878	5	1	4
23	R:R:D177	7.405	4	1	4
24	R:R:W183	4.5675	4	0	6
25	R:R:F225	7.0025	4	0	8
26	R:R:F232	5.97667	6	1	5
27	R:R:Q235	6.55	5	1	3
28	R:R:F236	5.908	5	1	4
29	R:R:F237	9.005	4	1	5
30	R:R:W241	10.025	6	1	3
31	R:R:F250	6.238	5	1	3
32	R:R:H254	9.366	5	1	1
33	R:R:N264	5.21	4	0	9
34	R:R:N268	7.124	5	2	9
35	R:R:I271	4.7975	4	0	8
36	R:R:Y272	6.25	5	2	9
37	R:R:F273	7.2525	4	3	7
38	R:R:F274	3.688	5	3	7
39	W:W:?1	13.7712	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S170	R:R:W241	11.1772	4.94	No	Yes	0	3	3
2	L:L:Q18	L:L:W14	19.6532	13.14	No	Yes	0	0	0
3	L:L:Q18	L:L:Y17	21.7875	13.53	No	Yes	0	0	0
4	L:L:Y17	R:R:F250	19.7254	10.32	Yes	Yes	1	0	3
5	L:L:Y17	W:W:?1	42.819	3.91	Yes	Yes	1	0	0
6	R:R:D177	R:R:W241	15.9738	13.4	Yes	Yes	1	4	3
7	L:L:R20	R:R:D177	19.4642	4.76	Yes	Yes	1	0	4
8	L:L:R20	R:R:F236	17.4189	4.28	Yes	Yes	1	0	4
9	R:R:F236	W:W:?1	38.6394	5.69	Yes	Yes	1	4	0
10	L:L:R20	R:R:E157	22.4211	8.14	Yes	Yes	1	0	4
11	L:L:Y21	R:R:Y99	14.8066	6.95	Yes	Yes	1	0	3
12	L:L:Y21	R:R:W158	10.2712	4.82	Yes	No	0	0	4
13	R:R:C23	R:R:F250	33.3204	2.79	No	Yes	0	2	3
14	R:R:C23	R:R:C251	25.528	7.28	No	No	0	2	1
15	R:R:T31	W:W:?1	19.1752	2.95	Yes	Yes	0	4	0
16	R:R:R79	W:W:?1	48.2937	12.17	Yes	Yes	1	6	0
17	R:R:F75	R:R:R79	53.5794	16.03	Yes	Yes	1	6	6
18	R:R:F75	R:R:S265	100	6.61	Yes	No	0	6	9
19	R:R:L76	R:R:S265	22.6434	4.5	No	No	0	7	9
20	R:R:L76	R:R:S266	10.5714	4.5	No	No	0	7	7
21	R:R:M102	W:W:?1	41.6296	15.11	No	Yes	1	4	0
22	R:R:F75	R:R:M102	41.952	4.98	Yes	No	1	6	4
23	R:R:L76	R:R:S38	11.0827	3	No	No	0	7	5
24	R:R:D72	R:R:S265	93.7417	10.31	Yes	No	0	9	9
25	R:R:D72	R:R:N45	43.6805	6.73	Yes	No	0	9	9
26	R:R:N45	R:R:P269	41.7519	8.15	No	No	0	9	9
27	R:R:F274	R:R:P269	39.8121	2.89	Yes	No	0	7	9
28	R:R:F274	R:R:V48	12.5	3.93	Yes	No	3	7	9
29	R:R:A69	R:R:V48	10.6936	3.39	No	No	0	9	9
30	R:R:F273	R:R:F274	17.4411	6.43	Yes	Yes	3	7	7
31	R:R:F273	R:R:L52	13.5671	8.53	Yes	Yes	0	7	7
32	R:R:E157	R:R:R153	36.6385	5.82	Yes	Yes	1	4	4
33	R:R:R153	R:R:S154	37.2832	2.64	Yes	No	0	4	6
34	R:R:F104	R:R:S154	35.9715	2.64	Yes	No	0	5	6
35	R:R:F104	R:R:W147	30.8304	6.01	Yes	Yes	0	5	9
36	R:R:N67	R:R:W147	10.6659	6.78	No	Yes	2	9	9
37	R:R:C143	R:R:N67	10.3991	12.6	No	No	2	7	9
38	R:R:C143	R:R:Y64	51.4562	4.03	No	Yes	0	7	7
39	R:R:E119	R:R:Y64	40.857	16.83	No	Yes	0	9	7
40	R:R:E119	R:R:R134	39.0396	11.63	No	Yes	0	9	9
41	R:R:F112	R:R:W147	19.2919	9.02	Yes	Yes	2	7	9
42	R:R:C143	R:R:F112	43.1303	6.98	No	Yes	2	7	7
43	R:R:D72	R:R:N268	34.2263	6.73	Yes	Yes	2	9	9
44	R:R:N268	R:R:Y272	22.8546	6.98	Yes	Yes	2	9	9
45	R:R:M103	R:R:Y99	11.6885	5.99	Yes	Yes	1	2	3
46	R:R:F232	R:R:M103	16.9297	3.73	Yes	Yes	1	5	2
47	R:R:F232	R:R:Y106	28.5516	6.19	Yes	Yes	0	5	7
48	R:R:L110	R:R:Y106	34.96	9.38	No	Yes	0	7	7
49	R:R:F225	R:R:L110	34.0874	4.87	Yes	No	0	8	7
50	R:R:F225	R:R:L113	13.7283	6.09	Yes	No	0	8	8
51	R:R:F107	R:R:R153	17.4744	14.97	Yes	Yes	1	6	4
52	R:R:F107	R:R:Y106	25.578	5.16	Yes	Yes	0	6	7
53	R:R:D72	R:R:L68	35.9827	5.43	Yes	No	2	9	9
54	R:R:F112	R:R:L68	45.2924	3.65	Yes	No	2	7	9
55	R:R:Y82	W:W:?1	32.7368	43.84	No	Yes	0	3	0
56	R:R:S95	R:R:Y82	30.0022	7.63	No	No	0	7	3
57	R:R:I94	R:R:S95	27.7068	4.64	No	No	0	5	7
58	R:R:I94	R:R:L98	13.8895	2.85	No	Yes	0	5	4
59	R:R:I94	R:R:L85	11.2717	7.14	No	No	0	5	4
60	R:R:F236	R:R:F237	12.5611	9.65	Yes	Yes	1	4	5
61	R:R:F107	R:R:L184	11.2995	7.31	Yes	No	0	6	8
62	R:R:F107	R:R:W183	13.1447	3.01	Yes	Yes	0	6	6
63	R:R:F225	R:R:L191	24.3553	7.31	Yes	No	0	8	8
64	R:R:L191	R:R:S117	22.6434	6.01	No	No	0	8	9
65	R:R:R120	R:R:S117	15.3735	5.27	Yes	No	0	9	9
66	R:R:R134	R:R:W129	26.6618	8	Yes	No	0	9	5
67	R:R:L122	R:R:W129	17.7023	3.42	No	No	0	6	5
68	R:R:L122	R:R:W126	15.4346	3.42	No	No	0	6	6
69	R:R:L125	R:R:W126	10.8659	12.53	No	No	0	7	6
70	R:R:L198	R:R:R120	12.1498	4.86	No	Yes	4	8	9
71	R:R:T221	R:R:Y272	15.568	7.49	No	Yes	0	8	9
72	R:R:E157	R:R:S176	16.9186	2.87	Yes	No	1	4	3
73	R:R:L198	R:R:L214	10.4824	4.15	No	No	0	8	7
74	R:R:N264	R:R:N268	18.9973	8.17	Yes	Yes	0	9	9
75	R:R:C251	R:R:E247	12.8168	4.56	No	No	0	1	2
76	R:R:S117	R:R:S195	11.7497	3.26	No	No	0	9	8
77	R:R:F232	R:R:Q235	16.0127	4.68	Yes	Yes	1	5	3
78	R:R:F232	R:R:R79	12.7446	10.69	Yes	Yes	1	5	6
79	R:R:F75	R:R:Y106	27.7623	7.22	Yes	Yes	0	6	7
80	R:R:R120	R:R:T221	12.4944	7.76	Yes	No	0	9	8
81	R:R:F250	R:R:H254	26.3395	4.53	Yes	Yes	1	3	1
82	R:R:F236	R:R:Y99	12.3055	6.19	Yes	Yes	1	4	3
83	R:R:E157	R:R:Y99	10.3602	6.73	Yes	Yes	1	4	3
84	R:R:H254	W:W:?1	18.6138	10.3	Yes	Yes	1	1	0
85	R:R:L68	R:R:N268	10.7992	6.87	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:G9	R:R:S170	3.71	0	No	No	0	3	0	1
L:L:P11	R:R:W241	5.4	1	No	Yes	0	3	0	1
L:L:W13	R:R:H243	23.27	1	No	No	0	1	0	1
L:L:W14	R:R:W241	4.69	1	Yes	Yes	0	3	0	1
L:L:M15	R:R:R246	8.69	1	No	No	0	2	0	1
L:L:M15	R:R:F250	7.46	1	No	Yes	0	3	0	1
L:L:Y17	R:R:F250	10.32	1	Yes	Yes	0	3	0	1
L:L:Y17	R:R:H254	14.16	1	Yes	Yes	0	1	0	1
L:L:Y17	W:W:?1	3.91	1	Yes	Yes	0	0	0	1
L:L:Q18	R:R:L240	6.65	0	No	No	0	4	0	1
L:L:R20	R:R:Y99	18.52	1	Yes	Yes	0	3	0	1
L:L:R20	R:R:E157	8.14	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:C161	5.57	1	Yes	No	0	4	0	1
L:L:R20	R:R:D177	4.76	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:F236	4.28	1	Yes	Yes	0	4	0	1
L:L:R20	R:R:L240	6.07	1	Yes	No	0	4	0	1
L:L:Y21	R:R:Y99	6.95	1	Yes	Yes	0	3	0	1
L:L:Y21	R:R:P100	5.56	1	Yes	No	0	4	0	1
L:L:Y21	R:R:W158	4.82	1	Yes	No	0	4	0	1
L:L:Y21	R:R:G162	4.35	1	Yes	No	0	2	0	1
R:R:M102	R:R:R79	7.44	1	No	Yes	4	6	2	2
R:R:I258	R:R:R79	13.78	1	No	Yes	4	6	2	2
R:R:R79	W:W:?1	12.17	1	Yes	Yes	6	0	2	1
R:R:Y82	W:W:?1	43.84	0	No	Yes	3	0	2	1
R:R:P100	R:R:Y99	8.34	1	No	Yes	4	3	1	1
R:R:M103	R:R:Y99	5.99	1	Yes	Yes	2	3	2	1
R:R:E157	R:R:Y99	6.73	1	Yes	Yes	4	3	1	1
R:R:F236	R:R:Y99	6.19	1	Yes	Yes	4	3	1	1
R:R:M102	W:W:?1	15.11	1	No	Yes	4	0	2	1
R:R:F236	R:R:M103	3.73	1	Yes	Yes	4	2	1	2
R:R:F237	R:R:M103	4.98	1	Yes	Yes	5	2	2	2
R:R:E157	R:R:R153	5.82	1	Yes	Yes	4	4	1	2
R:R:E157	R:R:F237	5.83	1	Yes	Yes	4	5	1	2
R:R:F163	R:R:W158	5.01	0	No	No	4	4	2	1
R:R:C161	R:R:C173	7.28	0	No	No	4	9	1	2
R:R:S170	R:R:W241	4.94	0	No	Yes	3	3	1	1
R:R:C173	R:R:D177	4.67	1	No	Yes	9	4	2	1
R:R:C173	R:R:W241	6.53	1	No	Yes	9	3	2	1
R:R:Q174	R:R:W241	25.19	0	No	Yes	3	3	2	1
R:R:D177	R:R:L240	6.79	1	Yes	No	4	4	1	1
R:R:D177	R:R:W241	13.4	1	Yes	Yes	4	3	1	1
R:R:H254	R:R:Q235	9.89	1	Yes	Yes	1	3	1	2
R:R:F236	R:R:F237	9.65	1	Yes	Yes	4	5	1	2
R:R:F236	W:W:?1	5.69	1	Yes	Yes	4	0	1	1
R:R:F239	R:R:V244	3.93	1	No	No	4	1	2	2
R:R:F239	R:R:L249	7.31	1	No	No	4	3	2	1
R:R:L249	R:R:V244	4.47	1	No	No	3	1	1	2
R:R:F250	R:R:H254	4.53	1	Yes	Yes	3	1	1	1
R:R:F250	R:R:L255	6.09	1	Yes	No	3	2	1	2
R:R:H254	R:R:I258	7.95	1	Yes	No	1	4	1	2
R:R:H254	W:W:?1	10.3	1	Yes	Yes	1	0	1	1
R:R:I258	W:W:?1	16.2	1	No	Yes	4	0	2	1
R:R:L164	R:R:W158	3.42	0	No	No	1	4	2	1
R:R:T31	W:W:?1	2.95	0	Yes	Yes	4	0	2	1
R:R:E157	R:R:S176	2.87	1	Yes	No	4	3	1	2
R:R:C23	R:R:F250	2.79	0	No	Yes	2	3	2	1
L:L:Y17	R:R:L249	2.34	1	Yes	No	0	3	0	1
R:R:F239	R:R:Q235	2.34	1	No	Yes	4	3	2	2
R:R:D169	R:R:S170	1.47	0	No	No	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:M15	L:L:Y17	11.97	1	No	Yes	0	0	2	1
L:L:M15	R:R:F250	7.46	1	No	Yes	0	3	2	2
L:L:Q18	L:L:Y17	13.53	0	No	Yes	0	0	2	1
L:L:Y17	R:R:F250	10.32	1	Yes	Yes	0	3	1	2
L:L:Y17	R:R:H254	14.16	1	Yes	Yes	0	1	1	1
L:L:Y17	W:W:?1	3.91	1	Yes	Yes	0	0	1	0
L:L:R20	R:R:Y99	18.52	1	Yes	Yes	0	3	2	2
L:L:R20	R:R:F236	4.28	1	Yes	Yes	0	4	2	1
R:R:S86	R:R:T31	6.4	0	No	Yes	2	4	2	1
R:R:F75	R:R:R79	16.03	1	Yes	Yes	6	6	2	1
R:R:F75	R:R:M102	4.98	1	Yes	No	6	4	2	1
R:R:M102	R:R:R79	7.44	1	No	Yes	4	6	1	1
R:R:F232	R:R:R79	10.69	1	Yes	Yes	5	6	2	1
R:R:I258	R:R:R79	13.78	1	No	Yes	4	6	1	1
R:R:R79	W:W:?1	12.17	1	Yes	Yes	6	0	1	0
R:R:S95	R:R:Y82	7.63	0	No	No	7	3	2	1
R:R:Y82	W:W:?1	43.84	0	No	Yes	3	0	1	0
R:R:M103	R:R:Y99	5.99	1	Yes	Yes	2	3	2	2
R:R:F236	R:R:Y99	6.19	1	Yes	Yes	4	3	1	2
R:R:M102	W:W:?1	15.11	1	No	Yes	4	0	1	0
R:R:F232	R:R:M103	3.73	1	Yes	Yes	5	2	2	2
R:R:F236	R:R:M103	3.73	1	Yes	Yes	4	2	1	2
R:R:F237	R:R:M103	4.98	1	Yes	Yes	5	2	2	2
R:R:F232	R:R:Q235	4.68	1	Yes	Yes	5	3	2	2
R:R:H254	R:R:Q235	9.89	1	Yes	Yes	1	3	1	2
R:R:F236	R:R:F237	9.65	1	Yes	Yes	4	5	1	2
R:R:F236	W:W:?1	5.69	1	Yes	Yes	4	0	1	0
R:R:F250	R:R:H254	4.53	1	Yes	Yes	3	1	2	1
R:R:H254	R:R:I258	7.95	1	Yes	No	1	4	1	1
R:R:H254	W:W:?1	10.3	1	Yes	Yes	1	0	1	0
R:R:I258	W:W:?1	16.2	1	No	Yes	4	0	1	0
R:R:S83	R:R:T31	3.2	0	No	Yes	6	4	2	1
R:R:T31	W:W:?1	2.95	0	Yes	Yes	4	0	1	0
L:L:Y17	R:R:L249	2.34	1	Yes	No	0	3	1	2
R:R:T31	R:R:V32	1.59	0	Yes	No	4	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DWG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	238
Number of Links	273
Number of Hubs	39
Number of Links mediated by Hubs	148
Number of Communities	4
Number of Nodes involved in Communities	51
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	48570
Length Of Smallest Path	3
Average Path Length	11.5169
Length of Longest Path	25
Minimum Path Strength	1.465
Average Path Strength	7.15407
Maximum Path Strength	30.02
Minimum Path Correlation	0.7
Average Path Correlation	0.914437
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	44.8727
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.0928
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • startle response • multicellular organismal process • system process • nervous system process • neuromuscular process • response to external stimulus • behavior • locomotory behavior • transmission of nerve impulse • aggressive behavior • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • G protein-coupled opioid receptor signaling pathway • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • sensory perception • sensory perception of pain • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • cellular anatomical structure • extracellular region • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • chromaffin granule lumen • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • chromaffin granule • intracellular organelle lumen
Gene Ontology	Cellular Component	• cellular anatomical structure • extracellular region • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • chromaffin granule lumen • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • chromaffin granule • intracellular organelle lumen • intracellular organelle • cytoplasmic vesicle • organelle lumen • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • somatodendritic compartment • cell body • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • synapse • axon terminus • presynapse • distal axon • cell junction • neuron projection terminus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • response to chloroquine • cell surface receptor signaling pathway • acute-phase response • defense response • response to stress • inflammatory response • acute inflammatory response • cell surface
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U39
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	U39
Name	2-[(cyclopropanesulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Synonyms
Identifier
Formula	C18 H20 N2 O4 S
Molecular Weight	360.427
SMILES
PubChem	71598556
Formal Charge	0
Total Atoms	45
Total Chiral Atoms	0
Total Bonds	47
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8DWG_nogp_Chain_R C Y K Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I S I P H T I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G F L F S G A D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JGF	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGF (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/β1/γ2	3	2024-01-10	10.1038/s41467-023-40705-z
	8JGG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		3	2024-01-10	10.1038/s41467-023-40705-z
	8JGB	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/β1/γ2	2.84	2024-01-10	10.1038/s41467-023-40705-z
	8JGB (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-		2.84	2024-01-10	10.1038/s41467-023-40705-z
	8HJ5	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-05-31	10.1371/journal.pbio.3001975
	8HJ5 (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3	2023-05-31	10.1371/journal.pbio.3001975
	8DWH	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWH (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3.25	2022-11-02	10.1038/s41589-022-01173-6
	8DWG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382		2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWC	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2022-11-02	10.1038/s41589-022-01173-6
	8DWC (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Proenkephalin-A	-		2.87	2022-11-02	10.1038/s41589-022-01173-6

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