Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E33 4.2775406
2A:A:L39 5.1175419
3A:A:S44 2.1775409
4A:A:I49 4.2675457
5A:A:M53 3.82458
6A:A:F189 7.705459
7A:A:F191 7.762555
8A:A:L194 4.555454
9A:A:F196 6.952557
10A:A:K197 4.6625416
11A:A:M198 2.794557
12A:A:F199 5.65415
13A:A:Q204 6.9325419
14A:A:K210 5.915619
15A:A:W211 5.93125819
16A:A:I212 4.02518
17A:A:H213 5.5425418
18A:A:C214 4.26417
19A:A:F215 5.08519
20A:A:F223 4.904519
21A:A:V225 4.25417
22A:A:L227 4.6675417
23A:A:Y230 4.22143718
24A:A:F250 4.96286719
25A:A:I253 3.8518
26A:A:C254 3.712515
27A:A:W258 4.726515
28A:A:F259 4.982519
29A:A:I265 2.4725408
30A:A:L266 3.868519
31A:A:F267 3.56625859
32A:A:L268 4.374518
33A:A:N269 3.732559
34A:A:F274 4.562519
35A:A:I278 6.5075416
36A:A:Y287 5.31254137
37A:A:Y290 7.1575407
38A:A:Y296 8.5775414
39A:A:Y302 9.63254136
40A:A:F307 5.07518
41A:A:L310 6.3925404
42A:A:K317 5417
43A:A:H322 7.2075459
44A:A:F323 3.985414
45A:A:N331 6.236558
46A:A:F336 5.62458
47B:B:T34 4.49254195
48B:B:I37 6.414192
49B:B:M45 6.1165104
50B:B:L51 7.076569
51B:B:H54 6.58286769
52B:B:Y59 7.44518
53B:B:M61 3.3825406
54B:B:W63 7.8025407
55B:B:L70 5.385465
56B:B:D76 4.635469
57B:B:K78 3.795468
58B:B:I81 3.608577
59B:B:W82 8.90333669
60B:B:N88 5.9225407
61B:B:K89 5.00167669
62B:B:H91 5.2725475
63B:B:I93 5.405477
64B:B:L95 4.088578
65B:B:W99 5.97625819
66B:B:Y105 4.9325476
67B:B:N110 6.8554144
68B:B:Y111 6.44144
69B:B:L117 3.576519
70B:B:C121 3.34418
71B:B:I123 3.47406
72B:B:Y124 4.135676
73B:B:L126 3.375475
74B:B:V133 4.65474
75B:B:L139 5.506509
76B:B:H142 7.084519
77B:B:Y145 4.9675818
78B:B:C149 3.4475408
79B:B:L152 3.9403
80B:B:I157 5407
81B:B:T159 6.155419
82B:B:S160 5.575436
83B:B:D163 7.712519
84B:B:L168 4.655436
85B:B:W169 8.13167618
86B:B:F180 6.166537
87B:B:H183 7.01639
88B:B:D186 7.81419
89B:B:V187 4.315439
90B:B:M188 4.2325418
91B:B:L190 4.4225435
92B:B:F199 6.548539
93B:B:V200 3.152546
94B:B:S201 4.058539
95B:B:D205 4.596539
96B:B:S207 4.105435
97B:B:K209 7.612536
98B:B:W211 8.838538
99B:B:C218 5.5075435
100B:B:F222 5.61548
101B:B:H225 9.222549
102B:B:D228 6.5419
103B:B:I232 4.715448
104B:B:F234 6.28445
105B:B:F235 5.151676156
106B:B:P236 5.674157
107B:B:F241 5.68125846
108B:B:T243 4.21648
109B:B:R251 6.96667648
110B:B:F253 7.8925446
111B:B:D254 3.5409
112B:B:R256 6.685409
113B:B:D258 7.176547
114B:B:Q259 3.976506
115B:B:M262 5.8175484
116B:B:T263 4.9475441
117B:B:Y264 4.53714785
118B:B:H266 8.0075484
119B:B:I269 3.2275484
120B:B:C271 4.6075405
121B:B:F278 3.6425157
122B:B:R283 9.6825409
123B:B:Y289 5.22833687
124B:B:N295 5.6825486
125B:B:W297 5.7325488
126B:B:R304 7.582585
127B:B:H311 8.3045109
128B:B:L318 4.0825406
129B:B:W332 10.1529719
130B:B:D333 6.0485109
131B:B:L336 4.648567
132B:B:K337 6.364106
133B:B:W339 6.76109
134G:G:R27 5.748548
135G:G:I28 4.445404
136G:G:D48 6.675609
137G:G:L51 5.975406
138G:G:F61 5.824568
139L:L:R17 6.7325420
140R:R:G41 1.88409
141R:R:L52 5.6856117
142R:R:F61 7.27427
143R:R:Y64 5.145607
144R:R:D72 8.985429
145R:R:F75 4.17333626
146R:R:L76 4.0375427
147R:R:R79 6.414526
148R:R:Y99 6.4475403
149R:R:M103 3.8875402
150R:R:Y106 6.74667627
151R:R:F107 6.154526
152R:R:F112 7.656527
153R:R:L113 4.4925428
154R:R:P127 2.945409
155R:R:Y130 5.33667697
156R:R:R134 6.718599
157R:R:W147 5.866529
158R:R:L203 4.0654125
159R:R:Y215 4.1254126
160R:R:I218 5.0825408
161R:R:F225 6.822508
162R:R:L230 2.776505
163R:R:F232 6.27425
164R:R:F236 7.282524
165R:R:F237 7.515625
166R:R:N268 3.99429
167R:R:I271 5.5475428
168R:R:Y272 6.514529
169R:R:F274 4.274117
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:M61 13.57342.83YesYes056
2B:B:C317 B:B:M61 36.18113.24NoYes076
3B:B:C317 B:B:S316 36.57253.44NoNo079
4B:B:S316 B:B:W332 36.77584.94NoYes099
5B:B:L336 B:B:M61 16.59664.24YesYes076
6A:A:W258 B:B:W332 87.53552.81YesYes159
7A:A:I212 A:A:W258 46.34282.35YesYes185
8A:A:I212 A:A:I253 54.63422.94YesYes188
9A:A:F223 A:A:I253 96.61242.51YesYes198
10A:A:F223 A:A:V225 98.09512.62YesYes197
11A:A:L268 A:A:V225 96.93582.98YesYes187
12A:A:L227 A:A:L268 97.05948.3YesYes178
13A:A:F274 A:A:L227 98.72683.65YesYes197
14A:A:F274 A:A:Y230 98.09565.16YesYes198
15A:A:K277 A:A:Y230 1005.97NoYes098
16A:A:K277 A:A:S228 99.91193.06NoNo099
17A:A:K270 A:A:S228 99.86763.06NoNo099
18A:A:K270 A:A:N269 99.82312.8NoYes099
19A:A:I49 A:A:N269 49.15335.66YesYes579
20A:A:I49 A:A:M53 48.51974.37YesYes578
21A:A:F189 A:A:M53 46.9644.98YesYes598
22A:A:F189 A:A:F196 47.138917.15YesYes597
23A:A:F196 A:A:L194 93.26747.31YesYes574
24A:A:L194 R:R:I128 93.51644.28YesNo046
25A:A:N256 A:A:W258 42.18535.65NoYes185
26A:A:I253 A:A:N256 41.87064.25YesNo188
27A:A:F267 A:A:N269 49.74722.42YesYes599
28A:A:F267 A:A:I222 48.04863.77YesNo097
29A:A:I222 A:A:L36 47.51832.85NoNo077
30A:A:F196 A:A:L36 47.76922.44YesNo077
31A:A:I212 A:A:W211 17.00453.52YesYes189
32A:A:W211 B:B:Y145 16.47634.82YesYes198
33B:B:G162 B:B:Y145 16.85344.35NoYes198
34B:B:G162 B:B:S161 16.75643.71NoNo199
35R:R:I128 R:R:P127 92.8811.69NoYes069
36A:A:N347 R:R:P127 92.03121.63NoYes089
37A:A:N347 R:R:Y130 91.57212.33NoYes987
38R:R:E119 R:R:Y130 87.36096.73NoYes997
39R:R:E119 R:R:Y64 87.39678.98NoYes097
40R:R:V116 R:R:Y64 41.51046.31NoYes087
41R:R:I65 R:R:V116 40.02413.07NoNo288
42R:R:I65 R:R:Y272 39.88274.84NoYes289
43R:R:L113 R:R:Y272 23.56185.86YesYes289
44R:R:F225 R:R:L113 46.65552.44YesYes088
45R:R:F225 R:R:L191 15.841118.27YesNo088
46R:R:L191 R:R:S117 12.2794.5NoNo089
47R:R:S117 R:R:S195 10.74973.26NoNo098
48R:R:C143 R:R:Y64 42.02074.03NoYes077
49R:R:C143 R:R:F112 39.78834.19NoYes277
50R:R:F112 R:R:L68 37.4622.44YesNo279
51R:R:L113 R:R:L68 23.4836.92YesNo289
52B:B:R314 B:B:W332 45.588920.99NoYes189
53B:B:D290 B:B:R314 42.79120.25NoNo168
54B:B:C271 B:B:D290 43.07146.22YesNo056
55B:B:C271 B:B:Y289 42.11554.03YesYes057
56B:B:I273 B:B:Y289 27.7929.67NoYes067
57B:B:G244 B:B:I273 28.54673.53NoNo056
58B:B:G244 B:B:T243 28.01543.64NoYes058
59B:B:M45 B:B:W339 13.17362.33YesYes1049
60B:B:N313 B:B:W332 17.09676.78NoYes079
61B:B:D333 B:B:N313 16.67112.69YesNo097
62B:B:D333 B:B:H311 15.38697.56YesYes1099
63B:B:I232 B:B:T243 18.44843.04YesYes488
64B:B:I232 B:B:S189 15.86256.19YesNo087
65B:B:G202 B:B:S189 15.62021.86NoNo067
66B:B:G202 B:B:S201 15.37781.86NoYes069
67B:B:H142 B:B:S161 15.524115.34YesNo199
68B:B:W297 B:B:Y289 11.88222.89YesYes887
69B:B:W297 B:B:Y264 11.33849.65YesYes885
70R:R:F225 R:R:L110 15.16332.44YesNo087
71R:R:L110 R:R:Y106 14.66489.38NoYes077
72R:R:F107 R:R:F237 13.14844.29YesYes265
73R:R:F225 R:R:L230 14.13994.87YesYes085
74R:R:N268 R:R:Y272 13.73772.33YesYes299
75R:R:D72 R:R:N268 27.09155.39YesYes299
76R:R:D72 R:R:S265 14.07810.31YesNo299
77R:R:F75 R:R:S265 13.74462.64YesNo269
78R:R:L68 R:R:N268 13.74675.49NoYes299
79R:R:D72 R:R:L76 11.10145.43YesYes297
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F15 R:R:F236 3.22 2 No Yes 0 4 0 1
L:L:R17 R:R:L160 7.29 2 Yes No 0 3 0 1
L:L:R17 R:R:F236 4.28 2 Yes Yes 0 4 0 1
L:L:R17 R:R:L240 12.15 2 Yes No 0 4 0 1
R:R:F236 R:R:Y99 3.09 2 Yes Yes 4 3 1 2
R:R:C161 R:R:L160 3.17 0 No No 4 3 2 1
R:R:D177 R:R:F237 13.14 0 No Yes 4 5 2 2
R:R:D177 R:R:L240 2.71 0 No No 4 4 2 1
R:R:F236 R:R:F237 16.08 2 Yes Yes 4 5 1 2
R:R:F236 R:R:L240 9.74 2 Yes No 4 4 1 1
L:L:R14 R:R:W241 2 0 No No 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
42.86Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
37.50Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
33.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
33.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
30.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
30.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
27.27Single7VV6C48/807VV6-MRGPRX2-C48/80
25.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
23.08Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.08Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
21.43Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
14.29Single6HLPNetupitant6HLP-NK1-Netupitant
14.29Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
14.29Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
13.64Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.33Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
13.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
13.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.33Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
13.33Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
13.33Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.33Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.76Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
11.76Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.76Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
11.11Single3RFMCaffeine3RFM-A2A-Caffeine
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.11Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
11.11Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.53Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.53Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
10.53Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
10.53Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.53Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
10.00Single3UZAGTPL92363UZA-A2A-GTPL9236
10.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
10.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
10.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
10.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
10.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
10.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
10.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
9.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.52Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
9.52Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
9.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
9.09Single3PBLEticlopride3PBL-D3-Eticlopride
9.09Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
9.09Single5NDZAZ3451; Na5NDZ-PAR2-AZ3451; Na
9.09Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.09Single6HLLCP999946HLL-NK1-CP99994
9.09Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.09Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
9.09Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.09Single6TP4ACT-4622066TP4-OX1-ACT-462206
9.09Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
9.09Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
9.09Single7SRQLSD7SRQ-5-HT2B-LSD
9.09Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
9.09Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
9.09Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.09Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
9.09Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
9.09Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
9.09Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
9.09Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.09Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
9.09Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.09Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
9.09Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
9.09Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
9.09Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
9.09Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.09Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.09Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
8.70Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
8.70Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
8.70Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33Single3PWHZM-2413853PWH-A2A-ZM-241385
8.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
8.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
8.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
8.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
8.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
8.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
8.33Single5WS3EMPA5WS3-OX2-EMPA
8.33Single6AKXA4R6AKX-CCR5-A4R
8.33Single6B73MP11046B73-κ-MP1104
8.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
8.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
8.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
8.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
8.33Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
8.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
8.33Single6TODEMPA6TOD-OX1-EMPA-Na
8.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
8.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
8.33Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
8.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
8.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
8.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
8.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
8.33Single7F8ULintitript7F8U-CCKA-Lintitript
8.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
8.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
8.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
8.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
8.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
8.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
8.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
8.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
8.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
8.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
8.33Single7XRRLemborexant7XRR-OX2-Lemborexant
8.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
8.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
8.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
8.33Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
8.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
8.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
8.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
8.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
8.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.33Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
8.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
8.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
8.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
8.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
8.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
8.33Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
8.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
8.33Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
8.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8.33Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
8.33Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
8.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
8.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
8.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
8.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
8.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
8.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
8.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
8.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
8.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
8.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
8.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
8.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
8.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
8.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.69Single2YDOAdenosine2YDO-A2A-Adenosine
7.69Single3REYXAC3REY-A2A-XAC
7.69Single3RZECidoxepin3RZE-H1-Cidoxepin
7.69Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
7.69Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
7.69Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
7.69Single4MBSMaraviroc4MBS-CCR5-Maraviroc
7.69Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
7.69Single4ZJCSB-6740424ZJC-OX1-SB-674042
7.69Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
7.69Single5IU7Q274563465IU7-A2A-Q27456346-Na
7.69Single5IUBQ274563445IUB-A2A-Q27456344-Na
7.69Single5JTBZM-2413855JTB-A2A-ZM-241385
7.69Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
7.69Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
7.69Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
7.69Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
7.69Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
7.69Single5UVIZM-2413855UVI-A2A-ZM-241385
7.69Single6AQFZM-2413856AQF-A2A-ZM-241385
7.69Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
7.69Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
7.69Single6IQLL7458706IQL-D4-L745870
7.69Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
7.69Single6MH8ZM-2413856MH8-A2A-ZM-241385
7.69Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
7.69Single6PS0S-Carazolol6PS0-β2-S-Carazolol
7.69Single6PS4ICI118-5516PS4-β2-ICI118-551
7.69Single6PS5S-Propranolol6PS5-β2-S-Propranolol
7.69Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
7.69Single6TP3Nemorexant6TP3-OX1-Nemorexant
7.69Single6TPGEMPA6TPG-OX2-EMPA
7.69Single6TPKRetosiban6TPK-OT-Retosiban
7.69Single6TPNHTL66416TPN-OX2-HTL6641
7.69Single6V9SGTPL114036V9S-OX1-GTPL11403
7.69Single6VI4JDTic6VI4-κ-JDTic
7.69Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
7.69Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
7.69Single6ZINSR486926ZIN-NTS1-SR48692
7.69Single7AROLUF58337ARO-A2A-LUF5833-Na
7.69Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
7.69Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
7.69Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
7.69Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
7.69Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
7.69Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
7.69Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
7.69Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
7.69Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
7.69Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
7.69Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
7.69Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
7.69Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
7.69Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
7.69Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
7.69Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
7.69Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
7.69Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
7.69Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
7.69Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
7.69Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
7.69Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
7.69Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.69Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
7.69Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
7.69Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
7.69Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
7.69Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
7.69Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.69Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.69Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
7.69Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
7.69Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
7.69Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
7.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9BJKNaloxone9BJK-μ-Naloxone-NAM
7.69Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
7.69Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
7.69Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
7.69Consensusa2_offOrthosteric Liganda2a_off
7.69Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
7.69Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
7.69Consensusalpha1_onOrthosteric Ligandalpha1a_on
7.69Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
7.69Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
7.69Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
7.69Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
7.69Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
7.69Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
7.69Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
7.69Consensusgrh_offOrthosteric Ligandgnrh1_off
7.69Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
7.69Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
7.69Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
7.69Consensusvasop-oxy_offOrthosteric Ligandot_off
7.41Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
7.41Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
7.41Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
7.14Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
7.14Single2Y02Carmoterol2Y02-β1-Carmoterol
7.14Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
7.14Single3EMLZM-2413853EML-A2A-ZM-241385
7.14Single3NY8ICI118-5513NY8-β2-ICI118-551
7.14Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
7.14Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
7.14Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
7.14Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
7.14Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
7.14Single4EJ4Naltrindole4EJ4-δ-Naltrindole
7.14Single4GBRS-Carazolol4GBR-β2-S-Carazolol
7.14Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
7.14Single4QIMANTA XV4QIM-SMO-ANTA XV
7.14Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
7.14Single5DHGC-355DHG-NOP-C-35
7.14Single5DHHSB-6121115DHH-NOP-SB-612111
7.14Single5IU8Q274563475IU8-A2A-Q27456347-Na
7.14Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
7.14Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
7.14Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
7.14Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
7.14Single5UENDU1725UEN-A1-DU172
7.14Single5UIGCmpd-15UIG-A2A-Cmpd-1
7.14Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
7.14Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
7.14Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
7.14Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
7.14Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
7.14Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
7.14Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
7.14Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
7.14Single6PS1Timolol6PS1-β2-Timolol
7.14Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
7.14Single6S0LZM-2413856S0L-A2A-ZM-241385
7.14Single6TOTLemborexant6TOT-OX1-Lemborexant
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.14Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
7.14Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
7.14Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
7.14Single7BU7BI1671077BU7-β1-BI167107
7.14Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
7.14Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
7.14Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7.14Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.14Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
7.14Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
7.14Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
7.14Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
7.14Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
7.14Single7PYRPSB-21157PYR-A2A-PSB-2115
7.14Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
7.14Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
7.14Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
7.14Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
7.14Single7UL4Alvimopan7UL4-μ-Alvimopan
7.14Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
7.14Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
7.14Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
7.14Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
7.14Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
7.14Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
7.14Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
7.14Single8CU6LJ-45178CU6-A2A-LJ-4517
7.14Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
7.14Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
7.14Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
7.14Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
7.14Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
7.14Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
7.14Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
7.14Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
7.14Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
7.14Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
7.14Single8JJOAlprenolol8JJO-β2-Alprenolol
7.14Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
7.14Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
7.14Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
7.14Single8RLNLUF58348RLN-A2A-LUF5834
7.14Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
7.14Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
7.14Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
7.14Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
7.14Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
7.14Single8X63Mepyramine8X63-H1-Mepyramine
7.14Single8X64Desloratadine8X64-H1-Desloratadine
7.14Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
7.14Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
7.14Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
7.14Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
7.14Single9CHXS-Carazolol9CHX-β2-S-Carazolol
7.14Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
7.14Single9IYAONO-97105319IYA-GPR55-ONO-9710531
7.14Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7.14Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
7.14Consensus5ht5_onOrthosteric Ligand5ht5a_on
7.14Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
7.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
7.14Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
7.14Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
7.14Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
7.14Consensusa3_onOrthosteric Liganda3a_on
7.14Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
7.14Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
7.14Consensusalpha2_onOrthosteric Ligandalpha2b_on
7.14Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
7.14Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
7.14Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
7.14Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
7.14Consensuscck_offOrthosteric Ligandccka_off
7.14Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
7.14Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
7.14Consensusdopamine_offOrthosteric Ligandd2_off d3_off
7.14Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
7.14Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
7.14Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
7.14Consensushistamine_offOrthosteric Ligandh1_off
7.14Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
7.14Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
7.14Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
6.67Single2RH1S-Carazolol2RH1-β2-S-Carazolol
6.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
6.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
6.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
6.67Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
6.67Single5C1MBU725C1M-μ-BU72
6.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
6.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
6.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
6.67Single5N2RPSB-365N2R-A2A-PSB-36-Na
6.67Single5N2SPSB365N2S-A1-PSB36
6.67Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
6.67Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
6.67Single5TVNLSD5TVN-5-HT2B-LSD
6.67Single5WQCEMPA5WQC-OX2-EMPA
6.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
6.67Single5XPRBosentan5XPR-ETB-Bosentan
6.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
6.67Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
6.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
6.67Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
6.67Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
6.67Single6PS6Timolol6PS6-β2-Timolol
6.67Single6S0QZM-2413856S0Q-A2A-ZM-241385
6.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
6.67Single6TP6Filorexant6TP6-OX1-Filorexant
6.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.67Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
6.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
6.67Single6Z4SSR486926Z4S-NTS1-SR48692
6.67Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
6.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
6.67Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
6.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
6.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
6.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
6.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
6.67Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
6.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
6.67Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
6.67Single7SINNPS-21437SIN-CaS-NPS-2143
6.67Single7SINNPS-21437SIN-CaS-NPS-2143
6.67Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
6.67Single7W41PD1762527W41-BB2-PD176252
6.67Single7WC6LSD7WC6-5-HT2A-LSD
6.67Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
6.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
6.67Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
6.67Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
6.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
6.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
6.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
6.67Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
6.67Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
6.67Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
6.67Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
6.67Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
6.67Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
6.67Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
6.67Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
6.67Single8QOTNanobody-E8QOT-μ-Nanobody-E
6.67Single8S4DCMF-0198S4D-Apelin-CMF-019
6.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
6.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.67Single8TF5Oleic acid8TF5-GPR6-Oleic acid
6.67Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
6.67Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
6.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.67Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
6.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
6.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
6.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
6.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
6.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
6.67Consensusa3_on_gpOrthosteric Liganda3a_on_gp
6.67Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
6.67Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
6.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
6.67Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
6.67Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
6.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
6.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
6.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
6.67Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
6.67Consensusamine_offonOrthosteric Ligandamine_off amine_on
6.67Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
6.67Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
6.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
6.67Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
6.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
6.67Consensusbombesin_offOrthosteric Ligandbb2_off
6.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
6.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.67Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
6.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
6.67Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
6.67Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
6.25Single2YDVNECA2YDV-A2A-NECA
6.25Single3P0GBI1671073P0G-β2-BI167107
6.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
6.25Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
6.25Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
6.25Single4BV0Neurotensin4BV0-NTS1-Neurotensin
6.25Single4DJHJDTic4DJH-κ-JDTic
6.25Single4UHRCGS216804UHR-A2A-CGS21680
6.25Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
6.25Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
6.25Single5D5AS-Carazolol5D5A-β2-S-Carazolol
6.25Single5D5BS-Carazolol5D5B-β2-S-Carazolol
6.25Single5G53NECA5G53-A2A-NECA-Gs
6.25Single5V56TC1145V56-SMO-TC114
6.25Single5XRAAM115425XRA-CB1-AM11542
6.25Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
6.25Single6E59L-7607356E59-NK1-L-760735
6.25Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
6.25Single6H7JIsoprenaline6H7J-β1-Isoprenaline
6.25Single6J20Aprepitant6J20-NK1-Aprepitant
6.25Single6J21Aprepitant6J21-NK1-Aprepitant
6.25Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
6.25Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
6.25Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
6.25Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.25Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
6.25Single6TQ7SB-3348676TQ7-OX1-SB-334867
6.25Single6WGTLSD6WGT-5-HT2A-LSD
6.25Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
6.25Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
6.25Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
6.25Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
6.25Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
6.25Single7FEECP559407FEE-CB1-CP55940-ZCZ011
6.25Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
6.25Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
6.25Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
6.25Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
6.25Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
6.25Single7P2L4YI7P2L-mGlu5-4YI
6.25Single7PX4PSB-21137PX4-A2A-PSB-2113
6.25Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
6.25Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
6.25Single7TUYGSK682753A7TUY-GPR183-GSK682753A
6.25Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
6.25Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
6.25Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
6.25Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
6.25Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
6.25Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
6.25Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
6.25Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
6.25Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
6.25Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
6.25Single8E0GBU728E0G-μ-BU72
6.25Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
6.25Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
6.25Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
6.25Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
6.25Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
6.25Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
6.25Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
6.25Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
6.25Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
6.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.25Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
6.25Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
6.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.25Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
6.25Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
6.25Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
6.25Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
6.25Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
6.25Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25Single8XVLZibotentan8XVL-ETA-Zibotentan
6.25Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
6.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
6.25Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
6.25Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
6.25Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusa2_onOrthosteric Liganda2b_on
6.25Consensusa2_on_gpOrthosteric Liganda2b_on_gp
6.25Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
6.25Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
6.25Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
6.25Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
6.25Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
6.25Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
6.25Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
6.25Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
6.25Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
6.25Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
6.25Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
6.25Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
6.25Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
6.25Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
6.25Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
6.25Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
6.25Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
6.25Consensuslpa_onOrthosteric Ligandlpa1_on
6.25Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
6.25Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusneurotensin_onOrthosteric Ligandnts1_on
6.25Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
6.25Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.25Consensustachykinin_offOrthosteric Ligandnk1_off
5.88Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
5.88Single3D4STimolol3D4S-β2-Timolol
5.88Single4AMIBucindolol4AMI-β1-Bucindolol
5.88Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
5.88Single4LDEBI1671074LDE-β2-BI167107
5.88Single4N4WSANT-14N4W-SMO-SANT-1
5.88Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.88Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.88Single4RWADIPP-NH24RWA-δ-DIPP-NH2
5.88Single4XEENeurotensin4XEE-NTS1-Neurotensin
5.88Single4XESNeurotensin4XES-NTS1-Neurotensin
5.88Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
5.88Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
5.88Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
5.88Single6KQICP559406KQI-CB1-CP55940-Org27569
5.88Single6MXTSalmeterol6MXT-β2-Salmeterol
5.88Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
5.88Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
5.88Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.88Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
5.88Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
5.88Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.88Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
5.88Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
5.88Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
5.88Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
5.88Single7YITNalfurafine7YIT-κ-Nalfurafine
5.88Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.88Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
5.88Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
5.88Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
5.88Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
5.88Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.88Single8JJ8Formoterol8JJ8-β2-Formoterol
5.88Single8JJLOlodaterol8JJL-β2-Olodaterol
5.88Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
5.88Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
5.88Single8JWY2-1188JWY-A2A-2-118
5.88Single8JWZAB9288JWZ-A2A-AB928-Na
5.88Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.88Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.88Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
5.88Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.88Single8XQJJN2418XQJ-Apelin-JN241
5.88Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
5.88Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
5.88Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
5.88Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.88Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.88Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
5.88Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
5.88Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
5.88Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.88Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.88Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
5.88Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
5.88Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.88Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.88Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.88Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
5.88Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
5.88Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
5.88Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
5.88Consensuslpa_offOrthosteric Ligandlpa1_off
5.88Consensuslpl_offOrthosteric Ligands1p_off lpa_off
5.88Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.88Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.88Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
5.88Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
5.88Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
5.88Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
5.88Consensusorexin_onOrthosteric Ligandox2_on
5.88Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.88Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.88Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.88Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
5.56Single4BUONeurotensin4BUO-NTS1-Neurotensin
5.56Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
5.56Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.56Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
5.56Single5X93K-87945X93-ETB-K-8794
5.56Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
5.56Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
5.56Single6H7LDobutamine6H7L-β1-Dobutamine
5.56Single6IBLArformoterol6IBL-β1-Arformoterol
5.56Single6K1QIRL25006K1Q-ETB-IRL2500
5.56Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
5.56Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
5.56Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
5.56Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
5.56Single7EZCUKA7EZC-A2A-UKA
5.56Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.56Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
5.56Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
5.56Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
5.56Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
5.56Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
5.56Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
5.56Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
5.56Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.56Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
5.56Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
5.56Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
5.56Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
5.56Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.56Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
5.56Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
5.56Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
5.56Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
5.56Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56Single8XVJMacitentan8XVJ-ETA-Macitentan
5.56Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.56Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
5.56Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
5.56Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.56Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.56Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
5.56Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56Consensuscck_onOrthosteric Ligandccka_on cckb_on
5.56Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
5.56Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.56Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.56Consensusendothelin_offOrthosteric Ligandetb_off
5.56Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
5.56Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
5.56Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.56Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
5.56Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
5.56Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
5.26Single3NY9ICI118-5513NY9-β2-ICI118-551
5.26Single4UG2CGS216804UG2-A2A-CGS21680
5.26Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
5.26Single5WF6UK-4320975WF6-A2A-UK-432097
5.26Single5ZTYAM102575ZTY-CB2-AM10257
5.26Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
5.26Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
5.26Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
5.26Single6PT3DPI-2876PT3-δ-DPI-287
5.26Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.26Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
5.26Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
5.26Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
5.26Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.26Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
5.26Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
5.26Single7XN9L-054,5227XN9-SST2-L-054,522
5.26Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
5.26Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
5.26Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
5.26Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
5.26Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
5.26Single8IEIA1LYA8IEI-GPR156-A1LYA
5.26Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8QJ2pN1628QJ2-MC4-pN162-Gs
5.26Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
5.26Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
5.26Single8X5YAstemizole8X5Y-H1-Astemizole
5.26Single8XQJJN2418XQJ-Apelin-JN241
5.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
5.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
5.26Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
5.26Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
5.26Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
5.26Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.26Consensuskisspeptin_onOrthosteric Ligandkiss1_on
5.26Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
5.26Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.26Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.26Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
5.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
5.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
5.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
5.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
5.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.00Single7F8XNN90567F8X-CCKA-NN9056
5.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
5.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
5.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
5.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
5.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
5.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
5.00Single8IEBA1LYA8IEB-GPR156-A1LYA
5.00Single8IEIA1LYA8IEI-GPR156-A1LYA
5.00Single8IEPA1LYA8IEP-GPR156-A1LYA
5.00Single8IEPA1LYA8IEP-GPR156-A1LYA
5.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.00Single8WDTphotoNECA8WDT-A2A-photoNECA
5.00Single8WKYPG-9348WKY-MC4-PG-934
5.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
5.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
5.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
5.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
5.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
5.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
5.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
5.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
4.76Single3QAKUK-4320973QAK-A2A-UK-432097
4.76Single6HLOAprepitant6HLO-NK1-Aprepitant
4.76Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.76Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.76Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
4.76Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
4.76Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
4.76Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.76Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
4.76Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
4.76Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
4.76Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8IEBA1LYA8IEB-GPR156-A1LYA
4.76Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
4.76Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
4.76Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.76Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.76Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
4.76Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
4.76Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.76Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.76Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.76Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.76Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
4.76Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
4.76Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.76Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.76Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.76Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.55Single5WF5UK-4320975WF5-A2A-UK-432097
4.55Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.55Single6PT2KGCHM076PT2-δ-KGCHM07
4.55Single6W25SHU91196W25-MC4-SHU9119-Ca
4.55Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
4.55Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
4.55Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.55Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
4.55Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
4.55Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
4.55Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
4.55Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
4.55Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
4.55Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.55Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
4.55Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.55Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.55Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
4.55Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
4.55Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
4.55Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
4.55Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
4.35Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
4.35Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
4.35Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.35Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
4.35Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
4.35Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
4.35Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
4.35Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
4.35Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
4.35Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
4.35Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
4.35Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.35Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
4.35Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.35Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
4.35Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
4.35Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
4.35Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
4.35Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.35Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
4.35Consensusvasop-oxy_onOrthosteric Ligandv2_on
4.35Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.17Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.17Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.17Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.17Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.17Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.17Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.17Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.17Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
4.17Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
4.17Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.17Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.17Single8ZRTET-18ZRT-ETB-ET-1
4.17Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.17Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
4.17Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
4.17Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.17Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
4.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
4.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
4.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.85Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
3.85Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
3.85Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
3.85Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.85Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
3.85Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
3.85Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
3.85Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
3.85Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
3.85Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
3.85Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
3.70Single6IGLIRL16206IGL-ETB-IRL1620
3.70Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
3.70Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.70Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
3.70Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.70Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.70Consensusbradykinin_onOrthosteric Ligandbk2_on
3.70Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
3.70Consensusendothelin_onOrthosteric Ligandetb_on eta_on
3.70Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.70Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
3.70Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
3.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.57Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.57Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.57Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.57Consensusbombesin_onOrthosteric Ligandbb2_on
3.57Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
3.57Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.57Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.57Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.45Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
3.45Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.45Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.45Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.45Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
3.03Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.03Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.56Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 8JGB
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRX1
Species Homo Sapiens
Ligand Conorfamide-Tx2
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.84
Date 2024-01-10
D.O.I. 10.1038/s41467-023-40705-z
Net Summary
Imin 2.33
Number of Linked Nodes 781
Number of Links 988
Number of Hubs 169
Number of Links mediated by Hubs 612
Number of Communities 23
Number of Nodes involved in Communities 258
Number of Links involved in Communities 385
Path Summary
Number Of Nodes in MetaPath 80
Number Of Links MetaPath 79
Number of Shortest Paths 1612902
Length Of Smallest Path 3
Average Path Length 32.9251
Length of Longest Path 58
Minimum Path Strength 1.25
Average Path Strength 5.13864
Maximum Path Strength 23.26
Minimum Path Correlation 0.7
Average Path Correlation 0.983955
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 38.0319
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.7359
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8JGB_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKITGI VETHFTFKD LHFKMFDVG GQRSERKKW IHCFEGVTA 
IIFCVALSD YDLVNRMHE SMKLFDSIC NNKWFTDTS IILFLNKKD 
LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE DLNKRKDTK 
EIYTHFTCA TDTKNVQFV FDAVTDVII KNNLKDCGL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JGB_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JGB_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF REK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB2
Sequence
>8JGB_Chain_R
LSLTVLTCI VSLVGLTGN AVVLWLLGC RMRRNAFSI YILNLAAAD 
FLFLSGRLI YSLLSKILY PVMMFSYFA GLSFLSAVS TERCLSVLW 
PIWYRCHRP THLSAVVCV LLWALSLLR SILEWMLCG QTSDFITVA 
WLIFLCVVL CGSSLVLLI RILCLTRLY VTILLTVLV FLLCGLPFG 
IQFFLFLWF CHVHLVSIF LSALNSSAN PIIYFFVGS F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JGFAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-1010.1038/s41467-023-40705-z
8JGF (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-2.72024-01-1010.1038/s41467-023-40705-z
8JGGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-Gi1/β1/γ232024-01-1010.1038/s41467-023-40705-z
8JGG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-32024-01-1010.1038/s41467-023-40705-z
8JGBAOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-Gi1/β1/γ22.842024-01-1010.1038/s41467-023-40705-z
8JGB (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-2.842024-01-1010.1038/s41467-023-40705-z
8HJ5AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ232023-05-3110.1371/journal.pbio.3001975
8HJ5 (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-32023-05-3110.1371/journal.pbio.3001975
8DWHAOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ23.252022-11-0210.1038/s41589-022-01173-6
8DWH (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-3.252022-11-0210.1038/s41589-022-01173-6
8DWGAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML382chim(NtGi2L-Gs-CtGq)/β1/γ22.712022-11-0210.1038/s41589-022-01173-6
8DWG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML3822.712022-11-0210.1038/s41589-022-01173-6
8DWCAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ22.872022-11-0210.1038/s41589-022-01173-6
8DWC (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-2.872022-11-0210.1038/s41589-022-01173-6




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