psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y82	3.07	Yes	No	0	0	3
2	L:L:?1	R:R:Y99	32.71	Yes	Yes	1	0	3
3	L:L:?1	R:R:E157	8.09	Yes	Yes	1	0	4
4	L:L:?1	R:R:C161	6.92	Yes	No	1	0	4
5	L:L:?1	R:R:C173	5.54	Yes	No	1	0	9
6	L:L:?1	R:R:D177	8.28	Yes	Yes	1	0	4
7	L:L:?1	R:R:L240	7.24	Yes	No	1	0	4
8	R:R:K25	R:R:Q26	4.07	No	No	0	2	1
9	R:R:Q26	R:R:T27	4.25	No	No	0	1	4
10	R:R:L28	R:R:V32	2.98	No	No	5	4	6
11	R:R:F87	R:R:L28	7.31	No	No	5	4	4
12	R:R:L30	R:R:S29	6.01	No	No	0	5	4
13	R:R:L255	R:R:L30	4.15	No	No	0	2	5
14	R:R:F259	R:R:L30	4.87	Yes	No	0	5	5
15	R:R:F87	R:R:V32	3.93	No	No	5	4	6
16	R:R:L33	R:R:V37	2.98	No	No	0	6	7
17	R:R:F259	R:R:L33	8.53	Yes	No	0	5	6
18	R:R:S83	R:R:T34	3.2	No	No	0	6	5
19	R:R:F259	R:R:T34	3.89	Yes	No	0	5	5
20	R:R:C35	R:R:L80	3.17	No	No	0	5	7
21	R:R:L263	R:R:V37	2.98	No	No	0	5	7
22	R:R:L76	R:R:S38	3	Yes	No	0	7	5
23	R:R:L39	R:R:L80	4.15	No	No	0	5	7
24	R:R:G41	R:R:S266	3.71	No	No	0	9	7
25	R:R:F73	R:R:L42	8.53	No	No	0	7	7
26	R:R:L42	R:R:L76	4.15	No	Yes	0	7	7
27	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
28	R:R:N45	R:R:P269	13.03	No	No	0	9	9
29	R:R:L51	R:R:V47	2.98	No	No	0	7	6
30	R:R:F274	R:R:V47	5.24	Yes	No	0	7	6
31	R:R:A69	R:R:V48	3.39	No	No	0	9	9
32	R:R:F273	R:R:V48	11.8	Yes	No	6	7	9
33	R:R:F274	R:R:V48	3.93	Yes	No	6	7	9
34	R:R:F273	R:R:L51	4.87	Yes	No	0	7	7
35	R:R:L52	R:R:S62	3	Yes	No	0	7	7
36	R:R:L52	R:R:L66	4.15	Yes	No	0	7	7
37	R:R:I63	R:R:R58	3.76	No	No	0	7	7
38	R:R:L66	R:R:R58	3.64	No	No	0	7	7
39	R:R:N59	R:R:S62	7.45	No	No	0	8	7
40	R:R:A60	R:R:R134	4.15	No	Yes	0	7	9
41	R:R:F61	R:R:I65	7.54	No	No	0	7	8
42	R:R:F61	R:R:V116	3.93	No	No	0	7	8
43	R:R:I63	R:R:S139	7.74	No	No	0	7	9
44	R:R:E119	R:R:Y64	16.83	No	Yes	0	9	7
45	R:R:S139	R:R:Y64	13.99	No	Yes	0	9	7
46	R:R:V142	R:R:Y64	5.05	No	Yes	0	6	7
47	R:R:C143	R:R:Y64	4.03	No	Yes	0	7	7
48	R:R:I65	R:R:Y272	4.84	No	Yes	0	8	9
49	R:R:F112	R:R:N67	4.83	Yes	No	4	7	9
50	R:R:C143	R:R:N67	7.87	No	No	4	7	9
51	R:R:N67	R:R:W147	4.52	No	Yes	4	9	9
52	R:R:D72	R:R:L68	8.14	Yes	No	0	9	9
53	R:R:F112	R:R:L68	6.09	Yes	No	0	7	9
54	R:R:L113	R:R:L68	4.15	Yes	No	0	8	9
55	R:R:D72	R:R:S265	11.78	Yes	No	0	9	9
56	R:R:D72	R:R:N268	6.73	Yes	Yes	0	9	9
57	R:R:L74	R:R:S77	3	No	No	0	7	5
58	R:R:L74	R:R:S105	3	No	No	0	7	8
59	R:R:F75	R:R:R79	9.62	Yes	Yes	0	6	6
60	R:R:F75	R:R:S105	3.96	Yes	No	0	6	8
61	R:R:F75	R:R:Y106	6.19	Yes	Yes	0	6	7
62	R:R:F75	R:R:S261	7.93	Yes	No	0	6	7
63	R:R:F75	R:R:S265	3.96	Yes	No	0	6	9
64	R:R:L76	R:R:S265	4.5	Yes	No	0	7	9
65	R:R:L76	R:R:S266	3	Yes	No	0	7	7
66	R:R:M102	R:R:R79	9.93	No	Yes	0	4	6
67	R:R:F232	R:R:R79	3.21	Yes	Yes	0	5	6
68	R:R:I258	R:R:R79	13.78	No	Yes	0	4	6
69	R:R:I81	R:R:L85	4.28	No	No	0	5	4
70	R:R:I81	R:R:L98	5.71	No	No	0	5	4
71	R:R:S95	R:R:Y82	3.82	No	No	0	7	3
72	R:R:L98	R:R:Y82	3.52	No	No	0	4	3
73	R:R:I90	R:R:L85	15.7	No	No	0	5	4
74	R:R:I90	R:R:P91	6.77	No	No	0	5	7
75	R:R:I94	R:R:L98	8.56	No	No	0	5	4
76	R:R:F163	R:R:K96	8.69	No	No	0	4	5
77	R:R:P100	R:R:Y99	6.95	No	Yes	0	4	3
78	R:R:M103	R:R:Y99	13.17	No	Yes	0	2	3
79	R:R:E157	R:R:Y99	8.98	Yes	Yes	1	4	3
80	R:R:F236	R:R:Y99	7.22	No	Yes	0	4	3
81	R:R:F104	R:R:W147	6.01	Yes	Yes	0	5	9
82	R:R:F104	R:R:S150	7.93	Yes	No	0	5	8
83	R:R:F107	R:R:Y106	6.19	Yes	Yes	0	6	7
84	R:R:L110	R:R:Y106	9.38	No	Yes	0	7	7
85	R:R:F232	R:R:Y106	7.22	Yes	Yes	0	5	7
86	R:R:F107	R:R:R153	10.69	Yes	Yes	1	6	4
87	R:R:F107	R:R:T180	3.89	Yes	No	1	6	5
88	R:R:F107	R:R:W183	3.01	Yes	No	0	6	6
89	R:R:F107	R:R:L184	7.31	Yes	No	0	6	8
90	R:R:F107	R:R:F237	4.29	Yes	Yes	1	6	5
91	R:R:A108	R:R:W147	5.19	No	Yes	0	7	9
92	R:R:A108	R:R:S150	3.42	No	No	0	7	8
93	R:R:F112	R:R:G109	3.01	Yes	No	0	7	9
94	R:R:F225	R:R:L110	6.09	Yes	No	0	8	7
95	R:R:L146	R:R:S111	7.51	No	No	0	7	6
96	R:R:L187	R:R:S111	3	No	No	0	9	6
97	R:R:C143	R:R:F112	5.59	No	Yes	4	7	7
98	R:R:F112	R:R:L146	4.87	Yes	No	0	7	7
99	R:R:F112	R:R:W147	7.02	Yes	Yes	4	7	9
100	R:R:F225	R:R:L113	6.09	Yes	Yes	0	8	8
101	R:R:L113	R:R:N268	5.49	Yes	Yes	3	8	9
102	R:R:L113	R:R:Y272	5.86	Yes	Yes	3	8	9
103	R:R:L187	R:R:S114	6.01	No	No	0	9	8
104	R:R:S114	R:R:V190	3.23	No	No	0	8	6
105	R:R:L191	R:R:S117	6.01	No	No	0	8	9
106	R:R:S117	R:R:S194	4.89	No	No	0	9	8
107	R:R:S194	R:R:T118	4.8	No	No	0	8	7
108	R:R:E119	R:R:Y130	12.35	No	Yes	2	9	7
109	R:R:E119	R:R:R134	9.3	No	Yes	2	9	9
110	R:R:R120	R:R:T221	9.06	No	No	0	9	8
111	R:R:C121	R:R:L125	3.17	No	Yes	7	8	7
112	R:R:C121	R:R:V197	3.42	No	No	7	8	4
113	R:R:S123	R:R:Y130	12.72	No	Yes	0	8	7
114	R:R:L198	R:R:V124	5.96	No	No	0	8	8
115	R:R:L125	R:R:W126	4.56	Yes	No	0	7	6
116	R:R:L125	R:R:V197	2.98	Yes	No	7	7	4
117	R:R:L125	R:R:R201	4.86	Yes	No	0	7	6
118	R:R:C132	R:R:I128	3.27	No	No	0	6	6
119	R:R:W129	R:R:Y130	5.79	No	Yes	2	5	7
120	R:R:R134	R:R:W129	3	Yes	No	2	9	5
121	R:R:R134	R:R:Y130	14.4	Yes	Yes	2	9	7
122	R:R:C132	R:R:H133	4.42	No	No	0	6	5
123	R:R:P135	R:R:R134	4.32	No	Yes	2	7	9
124	R:R:L138	R:R:R134	12.15	No	Yes	2	4	9
125	R:R:L138	R:R:P135	9.85	No	No	2	4	7
126	R:R:H137	R:R:T136	8.21	No	No	0	6	4
127	R:R:E157	R:R:R153	9.3	Yes	Yes	1	4	4
128	R:R:R153	R:R:T180	6.47	Yes	No	1	4	5
129	R:R:L156	R:R:L160	6.92	No	No	0	7	3
130	R:R:E157	R:R:F237	4.66	Yes	Yes	1	4	5
131	R:R:F163	R:R:W158	7.02	No	No	0	4	4
132	R:R:L164	R:R:W158	3.42	No	No	0	1	4
133	R:R:L160	R:R:M159	4.24	No	No	0	3	4
134	R:R:L164	R:R:M159	8.48	No	No	0	1	4
135	R:R:C161	R:R:C173	7.28	No	No	1	4	9
136	R:R:A168	R:R:F165	5.55	No	No	0	2	1
137	R:R:F165	R:R:W172	3.01	No	No	0	1	1
138	R:R:A171	R:R:D169	4.63	No	No	0	4	3
139	R:R:D169	R:R:W172	11.17	No	No	0	3	1
140	R:R:C173	R:R:D177	4.67	No	Yes	1	9	4
141	R:R:Q174	R:R:W241	3.29	No	No	0	3	3
142	R:R:D177	R:R:F237	3.58	Yes	Yes	1	4	5
143	R:R:D177	R:R:L240	8.14	Yes	No	1	4	4
144	R:R:F178	R:R:W241	6.01	No	No	0	3	3
145	R:R:F237	R:R:T180	11.67	Yes	No	1	5	5
146	R:R:L238	R:R:V181	5.96	No	No	0	5	5
147	R:R:L187	R:R:W183	4.56	No	No	0	9	6
148	R:R:F186	R:R:V190	3.93	No	No	0	5	6
149	R:R:F225	R:R:L191	8.53	Yes	No	0	8	8
150	R:R:C192	R:R:L226	4.76	No	No	0	5	6
151	R:R:I218	R:R:S195	3.1	No	No	0	8	8
152	R:R:S195	R:R:V222	3.23	No	No	0	8	8
153	R:R:I200	R:R:L196	4.28	No	No	0	5	4
154	R:R:L198	R:R:L214	4.15	No	No	0	8	7
155	R:R:I218	R:R:L199	5.71	No	No	0	8	5
156	R:R:I202	R:R:L214	5.71	No	No	0	6	7
157	R:R:L203	R:R:Y215	5.86	No	No	0	5	6
158	R:R:L211	R:R:Y215	7.03	No	No	0	6	6
159	R:R:R213	R:R:V275	3.92	No	No	0	7	8
160	R:R:I218	R:R:L214	5.71	No	No	0	8	7
161	R:R:L220	R:R:V224	2.98	No	No	3	6	7
162	R:R:I271	R:R:L220	4.28	Yes	No	3	8	6
163	R:R:T221	R:R:Y272	8.74	No	Yes	0	8	9
164	R:R:L226	R:R:V222	2.98	No	No	0	6	8
165	R:R:I271	R:R:V224	4.61	Yes	No	3	8	7
166	R:R:F225	R:R:L226	3.65	Yes	No	0	8	6
167	R:R:C228	R:R:L263	3.17	No	No	0	8	5
168	R:R:C228	R:R:N264	3.15	No	No	0	8	9
169	R:R:G229	R:R:N264	5.09	No	No	0	8	9
170	R:R:F232	R:R:F236	3.22	Yes	No	0	5	4
171	R:R:F232	R:R:S261	7.93	Yes	No	0	5	7
172	R:R:F237	R:R:G233	3.01	Yes	No	0	5	7
173	R:R:I234	R:R:L238	4.28	No	No	0	6	5
174	R:R:H254	R:R:Q235	7.42	No	No	0	1	3
175	R:R:Q235	R:R:S257	10.11	No	No	0	3	6
176	R:R:F236	R:R:F237	6.43	No	Yes	0	4	5
177	R:R:F239	R:R:V244	11.8	No	No	0	4	1
178	R:R:F239	R:R:L249	7.31	No	No	0	4	3
179	R:R:H243	R:R:I242	9.28	No	No	0	1	1
180	R:R:E247	R:R:R246	10.47	No	No	0	2	2
181	R:R:H252	R:R:V248	13.84	No	No	0	1	1
182	R:R:F250	R:R:H254	10.18	No	No	0	3	1
183	R:R:F250	R:R:L255	7.31	No	No	0	3	2
184	R:R:L260	R:R:V256	2.98	No	No	0	7	4
185	R:R:F259	R:R:L260	3.65	Yes	No	0	5	7
186	R:R:N264	R:R:N268	8.17	No	Yes	0	9	9
187	R:R:A267	R:R:I271	3.25	No	Yes	0	7	8
188	R:R:N268	R:R:Y272	3.49	Yes	Yes	3	9	9
189	R:R:I271	R:R:Y272	7.25	Yes	Yes	3	8	9
190	R:R:F273	R:R:F274	7.5	Yes	Yes	6	7	7
191	R:R:F274	R:R:S277	5.28	Yes	No	0	7	6
192	R:R:F278	R:R:S277	6.61	No	No	0	5	6
193	R:R:D169	R:R:S170	2.94	No	No	0	3	3
194	R:R:E157	R:R:S176	2.87	Yes	No	0	4	3
195	R:R:Q235	R:R:V253	2.87	No	No	0	3	4
196	R:R:I88	R:R:L84	2.85	No	No	0	3	5
197	R:R:I155	R:R:L151	2.85	No	No	0	4	4
198	R:R:I234	R:R:L184	2.85	No	No	0	6	8
199	R:R:A71	R:R:F112	2.77	No	Yes	0	9	7
200	R:R:L219	R:R:L223	2.77	No	No	0	5	6
201	R:R:A115	R:R:Y64	2.67	No	Yes	0	7	7
202	R:R:F163	R:R:S166	2.64	No	No	0	4	1
203	L:L:?1	R:R:K96	2.46	Yes	No	0	0	5
204	R:R:F273	R:R:L52	2.44	Yes	Yes	0	7	7
205	R:R:F165	R:R:L164	2.44	No	No	0	1	1
206	R:R:F225	R:R:L230	2.44	Yes	No	0	8	5
207	R:R:L52	R:R:R55	2.43	Yes	No	0	7	6
208	R:R:L199	R:R:Y215	2.34	No	No	0	5	6
209	R:R:L122	R:R:W126	2.28	No	No	0	6	6
210	R:R:L238	R:R:W241	2.28	No	No	0	5	3
211	R:R:G229	R:R:P231	2.03	No	No	0	8	9
212	R:R:C192	R:R:G193	1.96	No	No	0	5	4
213	R:R:G78	R:R:S77	1.86	No	No	0	5	5
214	R:R:G167	R:R:S166	1.86	No	No	0	1	1
215	R:R:G41	R:R:V40	1.84	No	No	0	9	6
216	R:R:G44	R:R:V47	1.84	No	No	0	8	6
217	R:R:G44	R:R:T43	1.82	No	No	0	8	5
218	R:R:C188	R:R:C192	1.82	No	No	0	6	5
219	R:R:C35	R:R:S83	1.72	No	No	0	5	6
220	R:R:C121	R:R:S194	1.72	No	No	0	8	8
221	R:R:A262	R:R:S38	1.71	No	No	0	6	5
222	R:R:G193	R:R:L196	1.71	No	No	0	4	4
223	R:R:C204	R:R:I200	1.64	No	No	0	5	5
224	R:R:S86	R:R:T27	1.6	No	No	0	2	4
225	R:R:S83	R:R:T31	1.6	No	No	0	6	4
226	R:R:C228	R:R:L227	1.59	No	No	0	8	5
227	R:R:A69	R:R:L49	1.58	No	No	0	9	7
228	R:R:A70	R:R:L49	1.58	No	No	0	6	7
229	R:R:T27	R:R:T31	1.57	No	No	0	4	4
230	R:R:T217	R:R:T221	1.57	No	No	0	7	8
231	R:R:I185	R:R:V181	1.54	No	No	0	5	5
232	R:R:I185	R:R:V189	1.54	No	No	0	5	4
233	R:R:I242	R:R:V244	1.54	No	No	0	1	1
234	R:R:C251	R:R:Q26	1.53	No	No	0	1	1
235	R:R:I94	R:R:T93	1.52	No	No	0	5	2
236	R:R:G53	R:R:R58	1.5	No	No	0	5	7
237	L:L:?1	R:R:G162	1.49	Yes	No	0	0	2
238	R:R:L74	R:R:V101	1.49	No	No	0	7	6
239	R:R:I94	R:R:I97	1.47	No	No	0	5	4
240	R:R:L160	R:R:T175	1.47	No	No	0	3	4
241	R:R:I179	R:R:L156	1.43	No	No	0	5	7
242	R:R:E247	R:R:V248	1.43	No	No	0	2	1
243	R:R:A46	R:R:F73	1.39	No	No	0	6	7
244	R:R:L146	R:R:L149	1.38	No	No	0	7	6
245	R:R:L199	R:R:L219	1.38	No	No	0	5	5
246	R:R:H252	R:R:V253	1.38	No	No	0	1	4
247	R:R:P127	R:R:W126	1.35	No	No	0	9	6
248	R:R:F104	R:R:S154	1.32	Yes	No	0	5	6
249	R:R:R153	R:R:S154	1.32	Yes	No	0	4	6
250	R:R:F239	R:R:V253	1.31	No	No	0	4	4
251	R:R:D245	R:R:E247	1.3	No	No	0	3	2
252	R:R:F87	R:R:I88	1.26	No	No	0	4	3
253	R:R:F104	R:R:L151	1.22	Yes	No	0	5	4
254	R:R:H133	R:R:W129	1.06	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.42222	9	1	0
2	R:R:L52	3.005	4	0	7
3	R:R:Y64	8.514	5	0	7
4	R:R:D72	8.345	4	0	9
5	R:R:F75	6.332	5	0	6
6	R:R:L76	3.6625	4	0	7
7	R:R:R79	9.135	4	0	6
8	R:R:Y99	13.806	5	1	3
9	R:R:F104	4.12	4	0	5
10	R:R:Y106	7.245	4	0	7
11	R:R:F107	5.89667	6	1	6
12	R:R:F112	4.88286	7	4	7
13	R:R:L113	5.3975	4	3	8
14	R:R:L125	3.8925	4	7	7
15	R:R:Y130	11.315	4	2	7
16	R:R:R134	7.88667	6	2	9
17	R:R:W147	5.685	4	4	9
18	R:R:R153	6.945	4	1	4
19	R:R:E157	6.78	5	1	4
20	R:R:D177	6.1675	4	1	4
21	R:R:F225	5.36	5	0	8
22	R:R:F232	5.395	4	0	5
23	R:R:F237	5.60667	6	1	5
24	R:R:F259	5.235	4	0	5
25	R:R:N268	5.97	4	3	9
26	R:R:I271	4.8475	4	3	8
27	R:R:Y272	6.036	5	3	9
28	R:R:F273	6.6525	4	6	7
29	R:R:F274	5.4875	4	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y99	36.7349	32.71	Yes	Yes	1	0	3
2	R:R:F236	R:R:Y99	40.7233	7.22	No	Yes	0	4	3
3	R:R:F232	R:R:F236	42.0074	3.22	Yes	No	0	5	4
4	R:R:F232	R:R:R79	11.1893	3.21	Yes	Yes	0	5	6
5	R:R:F75	R:R:R79	12.2646	9.62	Yes	Yes	0	6	6
6	R:R:F75	R:R:S265	61.2278	3.96	Yes	No	0	6	9
7	R:R:D72	R:R:S265	57.2803	11.78	Yes	No	0	9	9
8	R:R:D72	R:R:N268	58.6869	6.73	Yes	Yes	0	9	9
9	R:R:N264	R:R:N268	100	8.17	No	Yes	0	9	9
10	R:R:C228	R:R:N264	92.8264	3.15	No	No	0	8	9
11	R:R:C228	R:R:L263	87.9985	3.17	No	No	0	8	5
12	R:R:L263	R:R:V37	85.571	2.98	No	No	0	5	7
13	R:R:L33	R:R:V37	83.1344	2.98	No	No	0	6	7
14	R:R:F259	R:R:L33	80.6842	8.53	Yes	No	0	5	6
15	R:R:F259	R:R:T34	28.5585	3.89	Yes	No	0	5	5
16	R:R:S83	R:R:T34	25.9086	3.2	No	No	0	6	5
17	R:R:S83	R:R:T31	15.7357	1.6	No	No	0	6	4
18	R:R:T27	R:R:T31	13.0451	1.57	No	No	0	4	4
19	R:R:F232	R:R:Y106	24.7652	7.22	Yes	Yes	0	5	7
20	R:R:F75	R:R:Y106	44.5165	6.19	Yes	Yes	0	6	7
21	L:L:?1	R:R:E157	58.6914	8.09	Yes	Yes	1	0	4
22	R:R:E157	R:R:R153	42.2342	9.3	Yes	Yes	1	4	4
23	R:R:F107	R:R:R153	31.0677	10.69	Yes	Yes	1	6	4
24	R:R:F107	R:R:Y106	75.6931	6.19	Yes	Yes	0	6	7
25	R:R:E157	R:R:F237	25.6727	4.66	Yes	Yes	1	4	5
26	R:R:F107	R:R:F237	52.7066	4.29	Yes	Yes	1	6	5
27	L:L:?1	R:R:D177	22.7778	8.28	Yes	Yes	1	0	4
28	R:R:D177	R:R:F237	27.0339	3.58	Yes	Yes	1	4	5
29	R:R:F232	R:R:S261	10.2636	7.93	Yes	No	0	5	7
30	R:R:F75	R:R:S261	10.6175	7.93	Yes	No	0	6	7
31	R:R:L110	R:R:Y106	61.4547	9.38	No	Yes	0	7	7
32	R:R:F225	R:R:L110	61.2641	6.09	Yes	No	0	8	7
33	R:R:F225	R:R:L113	55.665	6.09	Yes	Yes	0	8	8
34	R:R:L113	R:R:N268	47.0212	5.49	Yes	Yes	3	8	9
35	R:R:F259	R:R:L30	46.4767	4.87	Yes	No	0	5	5
36	R:R:L76	R:R:S265	18.372	4.5	Yes	No	0	7	9
37	R:R:R153	R:R:S154	28.2272	1.32	Yes	No	0	4	6
38	R:R:F104	R:R:S154	28.5403	1.32	Yes	No	0	5	6
39	R:R:F104	R:R:W147	31.0268	6.01	Yes	Yes	0	5	9
40	R:R:N67	R:R:W147	13.6621	4.52	No	Yes	4	9	9
41	R:R:C143	R:R:N67	13.526	7.87	No	No	4	7	9
42	R:R:C143	R:R:Y64	61.4229	4.03	No	Yes	0	7	7
43	R:R:S139	R:R:Y64	37.6877	13.99	No	Yes	0	9	7
44	R:R:I63	R:R:S139	36.2358	7.74	No	No	0	7	9
45	R:R:I63	R:R:R58	34.752	3.76	No	No	0	7	7
46	R:R:L66	R:R:R58	31.7437	3.64	No	No	0	7	7
47	R:R:L52	R:R:L66	30.2237	4.15	Yes	No	0	7	7
48	R:R:F273	R:R:L52	24.0755	2.44	Yes	Yes	0	7	7
49	R:R:F112	R:R:W147	20.069	7.02	Yes	Yes	4	7	9
50	R:R:C143	R:R:F112	49.1991	5.59	No	Yes	4	7	7
51	R:R:L113	R:R:Y272	11.1348	5.86	Yes	Yes	3	8	9
52	R:R:F112	R:R:L68	42.9375	6.09	Yes	No	0	7	9
53	L:L:?1	R:R:Y82	40.1198	3.07	Yes	No	0	0	3
54	R:R:L98	R:R:Y82	32.7193	3.52	No	No	0	4	3
55	R:R:I81	R:R:L98	16.5978	5.71	No	No	0	5	4
56	R:R:I81	R:R:L85	12.4643	4.28	No	No	0	5	4
57	R:R:I94	R:R:L98	12.4643	8.56	No	No	0	5	4
58	R:R:F107	R:R:L184	17.3102	7.31	Yes	No	0	6	8
59	R:R:F225	R:R:L191	16.8474	8.53	Yes	No	0	8	8
60	R:R:L191	R:R:S117	15.3773	6.01	No	No	0	8	9
61	R:R:S117	R:R:S194	13.8799	4.89	No	No	0	9	8
62	R:R:C121	R:R:S194	10.858	1.72	No	No	0	8	8
63	R:R:E119	R:R:Y64	22.8686	16.83	No	Yes	0	9	7
64	R:R:F225	R:R:L226	28.8534	3.65	Yes	No	0	8	6
65	R:R:L226	R:R:V222	19.0254	2.98	No	No	0	6	8
66	R:R:S195	R:R:V222	17.5462	3.23	No	No	0	8	8
67	R:R:I218	R:R:S195	16.3392	3.1	No	No	0	8	8
68	R:R:E119	R:R:R134	12.1285	9.3	No	Yes	2	9	9
69	L:L:?1	R:R:K96	67.4713	2.46	Yes	No	0	0	5
70	R:R:F163	R:R:K96	63.8051	8.69	No	No	0	4	5
71	R:R:F163	R:R:W158	52.1757	7.02	No	No	0	4	4
72	R:R:L164	R:R:W158	48.1192	3.42	No	No	0	1	4
73	R:R:L164	R:R:M159	19.9374	8.48	No	No	0	1	4
74	R:R:L160	R:R:M159	15.8083	4.24	No	No	0	3	4
75	R:R:F165	R:R:L164	24.3659	2.44	No	No	0	1	1
76	R:R:F165	R:R:W172	16.1169	3.01	No	No	0	1	1
77	R:R:D169	R:R:W172	12.4643	11.17	No	No	0	3	1
78	R:R:I234	R:R:L184	15.4227	2.85	No	No	0	6	8
79	R:R:I234	R:R:L238	13.526	4.28	No	No	0	6	5
80	R:R:L255	R:R:L30	41.2995	4.15	No	No	0	2	5
81	R:R:F250	R:R:L255	39.2894	7.31	No	No	0	3	2
82	R:R:F250	R:R:H254	36.6804	10.18	No	No	0	3	1
83	R:R:H254	R:R:Q235	34.0533	7.42	No	No	0	1	3
84	R:R:Q235	R:R:V253	29.0122	2.87	No	No	0	3	4
85	R:R:F239	R:R:V253	13.0042	1.31	No	No	0	4	4
86	R:R:H252	R:R:V253	13.585	1.38	No	No	0	1	4
87	R:R:H252	R:R:V248	10.8852	13.84	No	No	0	1	1
88	R:R:D72	R:R:L68	21.0082	8.14	Yes	No	0	9	9
89	R:R:L113	R:R:L68	26.5212	4.15	Yes	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y82	3.07	1	Yes	No	0	3	0	1
L:L:?1	R:R:Y99	32.71	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:E157	8.09	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:C161	6.92	1	Yes	No	0	4	0	1
L:L:?1	R:R:C173	5.54	1	Yes	No	0	9	0	1
L:L:?1	R:R:D177	8.28	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L240	7.24	1	Yes	No	0	4	0	1
R:R:S95	R:R:Y82	3.82	0	No	No	7	3	2	1
R:R:L98	R:R:Y82	3.52	0	No	No	4	3	2	1
R:R:F163	R:R:K96	8.69	0	No	No	4	5	2	1
R:R:P100	R:R:Y99	6.95	0	No	Yes	4	3	2	1
R:R:M103	R:R:Y99	13.17	0	No	Yes	2	3	2	1
R:R:E157	R:R:Y99	8.98	1	Yes	Yes	4	3	1	1
R:R:F236	R:R:Y99	7.22	0	No	Yes	4	3	2	1
R:R:E157	R:R:R153	9.3	1	Yes	Yes	4	4	1	2
R:R:E157	R:R:F237	4.66	1	Yes	Yes	4	5	1	2
R:R:C161	R:R:C173	7.28	1	No	No	4	9	1	1
R:R:C173	R:R:D177	4.67	1	No	Yes	9	4	1	1
R:R:D177	R:R:F237	3.58	1	Yes	Yes	4	5	1	2
R:R:D177	R:R:L240	8.14	1	Yes	No	4	4	1	1
R:R:F236	R:R:F237	6.43	0	No	Yes	4	5	2	2
R:R:E157	R:R:S176	2.87	1	Yes	No	4	3	1	2
L:L:?1	R:R:K96	2.46	1	Yes	No	0	5	0	1
L:L:?1	R:R:G162	1.49	1	Yes	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DWH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	230
Number of Links	254
Number of Hubs	29
Number of Links mediated by Hubs	111
Number of Communities	7
Number of Nodes involved in Communities	36
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	54260
Length Of Smallest Path	3
Average Path Length	15.7243
Length of Longest Path	33
Minimum Path Strength	1.27
Average Path Strength	5.84175
Maximum Path Strength	19.83
Minimum Path Correlation	0.7
Average Path Correlation	0.921729
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	40.6411
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.8172
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • cellular process • signal transduction • cell communication • sneeze reflex • reflex • response to external stimulus • acute-phase response • defense response • response to stress • inflammatory response • acute inflammatory response • multicellular organismal process • system process • negative regulation of nervous system process • nervous system process • regulation of system process • negative regulation of biological process • sensory perception of pain • regulation of nervous system process • sensory perception • regulation of sensory perception • regulation of multicellular organismal process • regulation of sensory perception of pain • negative regulation of multicellular organismal process • negative regulation of sensory perception of pain • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to chemical • response to chloroquine • response to nitrogen compound • sensory perception of itch • cell surface • cellular anatomical structure • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U2U
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U2U
Name	N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide
Synonyms
Identifier
Formula	C23 H21 N3 O4 S
Molecular Weight	435.496
SMILES
PubChem	139030531
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8DWH_nogp_Chain_R K Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I S I P H T I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G F L F S G A D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8DWC	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.87	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWC (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.87	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	ML382	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.71	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	ML382		2.71	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWH	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8DWH (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3.25	2022-11-02	doi.org/10.1038/s41589-022-01173-6
	8HJ5	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2023-05-31	doi.org/10.1371/journal.pbio.3001975
	8HJ5 (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	PubChem 139030531	-		3	2023-05-31	doi.org/10.1371/journal.pbio.3001975
	8JGB	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/β1/γ2	2.84	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGB (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-		2.84	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGF	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGF (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		2.7	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGG	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/β1/γ2	3	2024-01-10	doi.org/10.1038/s41467-023-40705-z
	8JGG (No Gprot)	A	Orphan	Orphan	MRGPRX1	Homo sapiens	BAM8-22	-		3	2024-01-10	doi.org/10.1038/s41467-023-40705-z

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.