Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.8475402
2A:A:L45 5.2925468
3A:A:N50 8.34754179
4A:A:K53 5.944569
5A:A:I56 6.3467
6A:A:V214 6.66254106
7A:A:F219 7.612867108
8A:A:F222 9.1925417
9A:A:Q227 6.582519
10A:A:R231 10.33409
11A:A:K233 7.57619
12A:A:W234 9.382519
13A:A:F238 11.925419
14A:A:I244 4.66518
15A:A:V247 5.0125467
16A:A:Y253 7.4245188
17A:A:R265 10.10754179
18A:A:F273 5.91619
19A:A:W277 10.862516
20A:A:W281 12.125615
21A:A:F290 6.83667669
22A:A:N292 6.0975469
23A:A:Q294 7.0354126
24A:A:Y311 4.96754186
25A:A:F312 4.6625198
26A:A:Y339 4.3675403
27A:A:F340 9.4885197
28A:A:F345 8.775408
29A:A:Y360 12.6075408
30A:A:F363 11.355125
31A:A:T364 7.26569
32A:A:D368 5.125469
33A:A:N371 8.248569
34A:A:R374 7.53167664
35A:A:F376 7.675108
36A:A:Q385 3.9575405
37A:A:N387 7.89448
38A:A:E390 7.82444
39A:A:Y391 9.60167644
40A:A:L393 5.76408
41B:B:L14 5.0025218
42B:B:R22 8.3325406
43B:B:T34 6.3525485
44B:B:I37 5.614582
45B:B:H54 7.74143729
46B:B:Y59 5.7525418
47B:B:W63 7.74667627
48B:B:D76 7.25429
49B:B:K78 5.09408
50B:B:W82 11.375629
51B:B:Y85 14.105424
52B:B:N88 7.02407
53B:B:K89 7.95529
54B:B:I93 6.1725407
55B:B:L95 5.4285228
56B:B:W99 9.50571719
57B:B:M101 5.982519
58B:B:N110 8.24114
59B:B:Y111 8.514114
60B:B:L117 6.0675419
61B:B:N119 6.0825419
62B:B:I123 5.6925406
63B:B:Y124 6.16406
64B:B:L126 4.835405
65B:B:T128 3.6225403
66B:B:Y145 8.49618
67B:B:F151 5.975609
68B:B:L152 5.735473
69B:B:V158 4.99475
70B:B:W169 12.0745138
71B:B:Q176 8.1854134
72B:B:F180 9.176577
73B:B:H183 9.68579
74B:B:D186 9.0625419
75B:B:F199 9.5075479
76B:B:V200 9.5925456
77B:B:C204 7.2725417
78B:B:D205 7.6925479
79B:B:K209 10.696576
80B:B:W211 10.642578
81B:B:D212 6.18754239
82B:B:H225 11.426559
83B:B:D228 10.15519
84B:B:I232 5.8625458
85B:B:F234 5.88167655
86B:B:F235 8.7965156
87B:B:P236 7.464157
88B:B:F241 9.02656
89B:B:T243 6.2775458
90B:B:D246 7.215419
91B:B:R251 13.372558
92B:B:F253 9.27667656
93B:B:D254 5.5425409
94B:B:R256 6.935409
95B:B:D258 11.865457
96B:B:M262 6.82404
97B:B:Y264 6.616505
98B:B:I269 4.85754144
99B:B:F278 6.766157
100B:B:R283 8.51833689
101B:B:Y289 7.8456147
102B:B:N295 9.874146
103B:B:W297 7.794148
104B:B:L300 6.5625486
105B:B:K301 6.49685
106B:B:R304 11.0354145
107B:B:H311 9.386599
108B:B:R314 13.34518
109B:B:M325 5.766525
110B:B:W332 11.1267619
111B:B:D333 8.8175499
112B:B:K337 8.128596
113B:B:W339 10.11599
114G:G:V16 4.1025407
115G:G:D48 7.32409
116G:G:L51 4.365686
117G:G:P60 7.75429
118G:G:F61 6.5728
119L:L:W13 17.4425430
120L:L:W14 13.5275430
121L:L:Y17 13.748500
122L:L:R20 9.06833630
123L:L:Y21 5.2525430
124R:R:L51 5.885407
125R:R:L52 5.82254257
126R:R:F61 8.502547
127R:R:Y64 7.3025407
128R:R:D72 7.9175449
129R:R:F75 6.1406
130R:R:L80 5.815407
131R:R:Y99 10.145633
132R:R:M103 8.5575432
133R:R:F104 6.275405
134R:R:Y106 8.99537
135R:R:F107 10.6025436
136R:R:F112 6.9145167
137R:R:S117 6.4225409
138R:R:E119 9.08449
139R:R:R120 6.98409
140R:R:Y130 9.52667647
141R:R:R131 7.27446
142R:R:R134 8.095649
143R:R:W147 7.3825169
144R:R:R153 10.856534
145R:R:E157 9.7975434
146R:R:D177 7.618534
147R:R:I202 5.794206
148R:R:I218 5.3525408
149R:R:V224 3.86407
150R:R:F232 6.76833635
151R:R:F236 8.2434
152R:R:F237 6.845835
153R:R:L240 9.336534
154R:R:W241 8.572533
155R:R:L249 5.984243
156R:R:N268 8.532549
157R:R:Y272 7.07143749
158R:R:F273 9.71254257
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I244 A:A:V287 43.39944.61YesNo186
2A:A:F273 A:A:V287 43.15275.24YesNo196
3A:A:F273 A:A:F345 98.66636.43YesYes098
4A:A:F345 A:A:L270 97.449410.96YesNo086
5A:A:E344 A:A:L270 97.44535.3NoNo056
6A:A:E344 A:A:F340 97.04098.16NoYes1957
7A:A:F315 A:A:F340 98.575517.15NoYes067
8A:A:F315 A:A:I308 10012.56NoNo067
9A:A:I308 A:A:Y253 99.993112.09NoYes078
10A:A:Y253 A:A:Y311 99.85017.94YesYes1886
11A:A:N264 A:A:Y311 99.8885.81NoYes096
12A:A:D252 A:A:N264 99.87984.04NoNo089
13A:A:D252 A:A:N50 99.66175.39NoYes1789
14A:A:D249 A:A:N50 99.82910.77NoYes099
15A:A:D249 A:A:K293 99.600516.59NoNo099
16A:A:K293 A:A:N292 99.50364.2NoYes099
17A:A:I56 A:A:N292 32.81219.91YesYes679
18A:A:F290 A:A:I56 32.7355.02YesYes697
19A:A:F290 A:A:I375 15.28386.28YesNo099
20A:A:I245 A:A:I375 15.16785.89NoNo079
21A:A:I245 A:A:L43 15.06367.14NoNo077
22A:A:F219 A:A:L43 22.83596.09YesNo087
23A:A:F219 A:A:F376 21.17535.36YesYes1088
24A:A:F376 A:A:K380 21.04534.96YesNo087
25A:A:K380 R:R:I128 19.19065.82NoNo076
26A:A:I383 R:R:I128 19.01394.42NoNo086
27A:A:I383 A:A:N387 13.19824.25NoYes488
28A:A:N387 R:R:Y130 12.50029.3YesYes487
29B:B:C317 B:B:M61 29.17176.48NoNo076
30B:B:C317 B:B:S316 29.25375.16NoNo079
31B:B:S316 B:B:W332 29.3364.94NoYes099
32A:A:W281 B:B:W332 24.22414.69YesYes159
33A:A:N279 A:A:W281 37.02264.52NoYes185
34A:A:L282 A:A:N279 36.922713.73NoNo198
35A:A:I244 A:A:L282 37.07614.28YesNo189
36A:A:N292 A:A:T364 58.02375.85YesYes699
37A:A:F290 A:A:T364 32.70087.78YesYes699
38A:A:W234 B:B:Y145 54.76687.72YesYes198
39B:B:D186 B:B:Y145 17.014610.34YesYes198
40A:A:K233 A:A:Q236 22.9524.07YesNo198
41A:A:Q236 A:A:W281 19.496218.62NoYes185
42A:A:K233 B:B:D228 27.341311.06YesYes199
43A:A:R231 A:A:W234 56.296613YesYes099
44A:A:D272 A:A:R231 28.226513.1NoYes089
45A:A:K233 B:B:M188 32.313711.52YesNo098
46B:B:M188 B:B:Y145 32.42764.79NoYes088
47A:A:K233 B:B:D246 27.28855.53YesYes199
48A:A:F246 A:A:I276 28.32726.28NoNo098
49A:A:D378 A:A:Y360 74.487319.54NoYes078
50A:A:D378 A:A:H362 75.071612.61NoNo079
51A:A:F290 A:A:H362 50.11786.79YesNo699
52A:A:H362 A:A:R374 25.149119.18NoYes694
53A:A:R374 A:A:T364 25.15455.17YesYes649
54A:A:I358 A:A:Y360 73.510913.3NoYes048
55A:A:I358 A:A:Q385 73.31574.12NoYes045
56A:A:Q385 A:A:V394 72.53424.3YesNo058
57A:A:L388 A:A:V394 72.33947.45NoNo088
58A:A:L388 A:A:L393 72.1455.54NoYes088
59A:A:L393 R:R:R120 70.2594.86YesYes089
60B:B:D228 B:B:S227 43.19894.42YesNo196
61B:B:D247 B:B:S227 69.67414.42NoNo096
62B:B:D247 B:B:T249 68.4935.78NoNo096
63B:B:R251 B:B:T249 67.31156.47YesNo086
64B:B:F253 B:B:R251 60.77935.34YesYes568
65B:B:F222 B:B:F253 46.512516.08NoYes586
66B:B:F222 B:B:Q220 45.98267.03NoNo587
67B:B:D258 B:B:Q220 44.791415.66YesNo577
68B:B:D258 B:B:R22 42.414415.48YesYes076
69B:B:I18 B:B:R22 10.17315.01NoYes076
70B:B:D246 B:B:S227 27.06565.89YesNo196
71B:B:M325 G:G:P49 23.58486.71YesNo057
72G:G:D48 G:G:P49 23.31654.83YesNo097
73G:G:D48 G:G:L51 19.25456.79YesYes096
74B:B:R283 G:G:L51 14.63464.86YesYes896
75B:B:L30 B:B:T34 12.84884.42NoYes055
76B:B:L30 B:B:M262 11.43817.07NoYes054
77B:B:R22 G:G:E22 29.89273.49YesNo069
78B:B:T221 G:G:E22 29.29658.47NoNo079
79B:B:K209 B:B:T221 28.700315.02YesNo067
80B:B:K209 B:B:W211 17.34688.12YesYes768
81B:B:T321 B:B:W63 24.069312.13NoYes277
82B:B:D323 B:B:T321 23.88197.23NoNo277
83B:B:D323 B:B:M325 23.80618.32NoYes275
84B:B:F241 B:B:F253 11.327111.79YesYes566
85B:B:M262 B:B:Y264 10.427810.78YesYes045
86R:R:R120 R:R:S117 14.82645.27YesYes099
87R:R:L191 R:R:S117 11.51659.01NoYes089
88R:R:F225 R:R:L191 11.080218.27NoNo088
89R:R:C188 R:R:F225 10.86334.19NoNo068
90R:R:F107 R:R:F237 14.26865.36YesYes365
91R:R:D177 R:R:F237 11.63018.36YesYes345
92R:R:R120 R:R:T221 46.37756.47YesNo098
93R:R:T221 R:R:Y272 46.164211.24NoYes089
94R:R:N268 R:R:Y272 44.77025.81YesYes499
95R:R:D72 R:R:N268 43.7448.08YesYes499
96R:R:D72 R:R:S265 43.11987.36YesNo099
97R:R:F75 R:R:S265 40.12487.93YesNo069
98R:R:F75 R:R:Y106 23.76717.22YesYes067
99R:R:F232 R:R:Y106 14.925712.38YesYes357
100R:R:F232 R:R:R79 15.23894.28YesNo056
101R:R:I258 R:R:R79 12.076718.79NoNo046
102L:L:Y17 R:R:H254 13.313330.49YesNo001
103R:R:F75 R:R:S261 15.07366.61YesNo067
104R:R:F232 R:R:S261 14.85567.93YesNo057
105R:R:F232 R:R:S257 10.6895.28YesNo056
106R:R:Q235 R:R:S257 10.236610.11NoNo036
107L:L:Y17 R:R:F250 10.81337.22YesNo003
108R:R:E119 R:R:Y64 15.203412.35YesYes097
109R:R:C143 R:R:Y64 13.99964.03NoYes077
110B:B:C204 B:B:D186 16.54347.78YesYes179
111A:A:I276 A:A:R231 28.250211.27NoYes089
112A:A:D272 A:A:F246 28.24518.36NoNo089
113B:B:C204 B:B:D228 16.251610.89YesYes179
114A:A:F246 A:A:F273 56.54038.57NoYes099
115B:B:M61 B:B:W63 26.87965.82NoYes267
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:W13 R:R:H243 45.49 3 Yes No 0 1 0 1
L:L:W14 R:R:L240 17.08 3 Yes Yes 0 4 0 1
L:L:W14 R:R:W241 6.56 3 Yes Yes 0 3 0 1
L:L:M15 R:R:R246 17.37 0 No No 0 2 0 1
L:L:Y17 R:R:L249 4.69 0 Yes Yes 0 3 0 1
L:L:Y17 R:R:F250 7.22 0 Yes No 0 3 0 1
L:L:Y17 R:R:H254 30.49 0 Yes No 0 1 0 1
L:L:Q18 R:R:L240 7.99 0 No Yes 0 4 0 1
L:L:R20 R:R:Y99 14.4 3 Yes Yes 0 3 0 1
L:L:R20 R:R:E157 9.3 3 Yes Yes 0 4 0 1
L:L:R20 R:R:D177 11.91 3 Yes Yes 0 4 0 1
L:L:R20 R:R:F236 5.34 3 Yes Yes 0 4 0 1
L:L:R20 R:R:L240 7.29 3 Yes Yes 0 4 0 1
L:L:Y21 R:R:Y99 5.96 3 Yes Yes 0 3 0 1
L:L:Y21 R:R:P100 6.95 3 Yes No 0 4 0 1
R:R:P100 R:R:Y99 5.56 3 No Yes 4 3 1 1
R:R:M103 R:R:Y99 15.57 3 Yes Yes 2 3 2 1
R:R:E157 R:R:Y99 10.1 3 Yes Yes 4 3 1 1
R:R:F236 R:R:Y99 9.28 3 Yes Yes 4 3 1 1
R:R:F236 R:R:M103 7.46 3 Yes Yes 4 2 1 2
R:R:F237 R:R:M103 4.98 3 Yes Yes 5 2 2 2
R:R:E157 R:R:R153 12.79 3 Yes Yes 4 4 1 2
R:R:F237 R:R:R153 5.34 3 Yes Yes 5 4 2 2
R:R:E157 R:R:F237 7 3 Yes Yes 4 5 1 2
R:R:Q174 R:R:W241 8.76 0 No Yes 3 3 2 1
R:R:D177 R:R:F237 8.36 3 Yes Yes 4 5 1 2
R:R:D177 R:R:L240 4.07 3 Yes Yes 4 4 1 1
R:R:D177 R:R:W241 12.28 3 Yes Yes 4 3 1 1
R:R:F178 R:R:W241 5.01 0 No Yes 3 3 2 1
R:R:Q235 R:R:V253 5.73 0 No No 3 4 2 2
R:R:H254 R:R:Q235 8.65 0 No No 1 3 1 2
R:R:F236 R:R:F237 10.72 3 Yes Yes 4 5 1 2
R:R:F239 R:R:V244 6.55 24 No No 4 1 2 2
R:R:F239 R:R:L249 7.31 24 No Yes 4 3 2 1
R:R:L240 R:R:W241 10.25 3 Yes Yes 4 3 1 1
R:R:L249 R:R:V244 5.96 24 Yes No 3 1 1 2
R:R:L249 R:R:V253 5.96 24 Yes No 3 4 1 2
R:R:F250 R:R:L255 10.96 0 No No 3 2 1 2
R:R:H254 R:R:I258 7.95 0 No No 1 4 1 2
L:L:Y21 R:R:W158 1.93 3 Yes No 0 4 0 1
R:R:D177 R:R:S176 1.47 3 Yes No 4 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
76.47Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
68.75Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
47.06Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
40.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
38.89Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
37.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
36.84Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
36.84Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
36.84Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
35.29Single7VV6C48/807VV6-MRGPRX2-C48/80
35.29Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
35.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
35.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
35.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
31.82Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
31.25Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
30.43Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
30.43Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
30.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
29.41Single7F8YDevazepide7F8Y-CCKA-Devazepide
29.41Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
29.41Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
28.57Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
28.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
28.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
28.57Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
27.27Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
27.27Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
27.27Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
26.32Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
25.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
25.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
25.00Single6Z4SSR486926Z4S-NTS1-SR48692
25.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
25.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
25.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
25.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
24.14Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
24.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.81Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.81Single4BV0Neurotensin4BV0-NTS1-Neurotensin
23.81Single5TZRMK86665TZR-FFA1-MK8666
23.81Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
23.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.81Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.81Consensusneurotensin_onOrthosteric Ligandnts1_on
23.81Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
23.81Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
23.53Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7UL2SR486927UL2-NTS1-SR48692-Na
23.53Consensusneurotensin_offOrthosteric Ligandnts1_off
23.53Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
23.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.08Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
23.08Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
23.08Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
23.08Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
22.73Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.73Single4XEENeurotensin4XEE-NTS1-Neurotensin
22.73Single4XESNeurotensin4XES-NTS1-Neurotensin
22.73Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
22.73Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.73Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.73Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
22.73Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.73Single8XWSCXCL58XWS-CXCR2-CXCL5
22.73Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.73Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
22.73Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.58Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.58Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
22.58Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
22.22Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
22.22Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
22.22Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
22.22Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.22Single7F8ULintitript7F8U-CCKA-Lintitript
22.22Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
22.22Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
22.22Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
22.22Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
22.22Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.88Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.74Single4BUONeurotensin4BUO-NTS1-Neurotensin
21.74Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.74Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.74Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
21.74Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.74Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.74Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.43Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.43Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
21.43Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.43Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.05Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
21.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
21.05Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.05Single5JTBZM-2413855JTB-A2A-ZM-241385
21.05Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
21.05Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
21.05Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
21.05Single5UVIZM-2413855UVI-A2A-ZM-241385
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
21.05Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
21.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
21.05Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
21.05Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
21.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
21.05Consensusa2_offOrthosteric Liganda2a_off
21.05Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensusvasop-oxy_offOrthosteric Ligandot_off
20.83Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.83Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.83Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.83Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.83Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Single8QJ2pN1628QJ2-MC4-pN162-Gs
20.69Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.69Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.59Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single3EMLZM-2413853EML-A2A-ZM-241385
20.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
20.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
20.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
20.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
20.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
20.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
20.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6S0LZM-2413856S0L-A2A-ZM-241385
20.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7PYRPSB-21157PYR-A2A-PSB-2115
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8WKYPG-9348WKY-MC4-PG-934
20.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
19.35Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
19.23Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
19.23Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
19.23Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
19.23Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.23Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.23Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
19.23Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
19.05Single5IUAQ274563485IUA-A2A-Q27456348-Na
19.05Single5N2SPSB365N2S-A1-PSB36
19.05Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
19.05Single6HLPNetupitant6HLP-NK1-Netupitant
19.05Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
19.05Single6S0QZM-2413856S0Q-A2A-ZM-241385
19.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.05Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
19.05Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
19.05Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.05Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
19.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
19.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
19.05Single8GNEKW-63568GNE-A2A-KW-6356-Na
19.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8QOTNanobody-E8QOT-μ-Nanobody-E
19.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.05Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.05Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.75Single3RFMCaffeine3RFM-A2A-Caffeine
18.75Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.75Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
18.75Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
18.52Single3OE0CVX153OE0-CXCR4-CVX15
18.52Single6W25SHU91196W25-MC4-SHU9119-Ca
18.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
18.52Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
18.52Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
18.52Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
18.52Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
18.18Single5V56TC1145V56-SMO-TC114
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
18.18Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
18.18Single7PX4PSB-21137PX4-A2A-PSB-2113
18.18Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
18.18Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
18.18Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
18.18Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
18.18Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.18Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
18.18Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.18Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.18Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Consensuslpa_onOrthosteric Ligandlpa1_on
18.18Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
18.18Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
18.18Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
18.18Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
17.86Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
17.86Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
17.86Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
17.65Single4XNWMRS25004XNW-P2Y1-MRS2500
17.65Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.65Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
17.65Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
17.65Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
17.65Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.39Single4RWADIPP-NH24RWA-δ-DIPP-NH2
17.39Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.39Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.39Single7YITNalfurafine7YIT-κ-Nalfurafine
17.39Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XWACXCL18XWA-CXCR2-CXCL1
17.39Single8XWMCXCL68XWM-CXCR2-CXCL6
17.39Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
17.39Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
17.39Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.39Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
17.39Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
17.39Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
17.39Consensusorexin_onOrthosteric Ligandox2_on
17.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.24Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.24Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.24Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
17.24Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
16.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7SK3CXCL127SK3-ACKR3-CXCL12
16.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
16.67Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
16.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
16.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
16.67Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
16.67Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
16.67Single8XVUCXCL28XVU-CXCR2-CXCL2
16.67Single8XWFCXCL38XWF-CXCR2-CXCL3
16.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
16.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
16.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
16.67Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
16.67Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensuscck_onOrthosteric Ligandccka_on cckb_on
16.67Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
16.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
16.67Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
16.67Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
16.13Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
16.13Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
16.13Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
16.13Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
16.13Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
16.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
16.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single3PWHZM-2413853PWH-A2A-ZM-241385
15.79Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
15.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.79Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.79Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.79Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.79Single5WS3EMPA5WS3-OX2-EMPA
15.79Single6TODEMPA6TOD-OX1-EMPA-Na
15.79Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7XRRLemborexant7XRR-OX2-Lemborexant
15.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.79Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.79Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.79Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.79Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.79Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.79Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.79Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
15.79Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.62Single6IGLIRL16206IGL-ETB-IRL1620
15.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
15.62Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.62Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single7F8XNN90567F8X-CCKA-NN9056
15.38Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
15.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8IEBA1LYA8IEB-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.38Single8XWNCXCL88XWN-CXCR2-CXCL8
15.38Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.38Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
15.38Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensussomatostatin_offOrthosteric Ligandsst2_off
15.38Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.15Single5GLHEndothelin-15GLH-ETB-Endothelin-1
15.15Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.15Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.15Consensusbombesin_onOrthosteric Ligandbb2_on
15.15Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
15.15Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.15Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.00Single3REYXAC3REY-A2A-XAC
15.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
15.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.00Single6AQFZM-2413856AQF-A2A-ZM-241385
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.00Single6TPNHTL66416TPN-OX2-HTL6641
15.00Single6V9SGTPL114036V9S-OX1-GTPL11403
15.00Single6ZINSR486926ZIN-NTS1-SR48692
15.00Single7AROLUF58337ARO-A2A-LUF5833-Na
15.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
15.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
15.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
15.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
15.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
15.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
14.81Single3QAKUK-4320973QAK-A2A-UK-432097
14.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single7XNACYN1548067XNA-SST2-CYN154806
14.81Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
14.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
14.81Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
14.81Single8IEBA1LYA8IEB-GPR156-A1LYA
14.81Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.81Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
14.81Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.81Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.81Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.81Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.81Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
14.81Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
14.81Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.71Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Single4QIMANTA XV4QIM-SMO-ANTA XV
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single5UENDU1725UEN-A1-DU172
14.29Single5UIGCmpd-15UIG-A2A-Cmpd-1
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
14.29Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
14.29Single6PT2KGCHM076PT2-δ-KGCHM07
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.29Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
14.29Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
14.29Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
14.29Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
14.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
14.29Single8CU6LJ-45178CU6-A2A-LJ-4517
14.29Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
14.29Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
14.29Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
14.29Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
14.29Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
14.29Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
14.29Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
14.29Consensusa3_onOrthosteric Liganda3a_on
14.29Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
14.29Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.29Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
14.29Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
14.29Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
14.29Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.29Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
14.29Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
13.79Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.79Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.79Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.79Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
13.79Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.64Single4JKVTaladegib4JKV-SMO-Taladegib
13.64Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
13.64Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
13.64Single5N2RPSB-365N2R-A2A-PSB-36-Na
13.64Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
13.64Single5WQCEMPA5WQC-OX2-EMPA
13.64Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.64Single6TP6Filorexant6TP6-OX1-Filorexant
13.64Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
13.64Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
13.64Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7W41PD1762527W41-BB2-PD176252
13.64Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
13.64Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
13.64Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
13.64Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.64Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.64Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
13.64Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
13.64Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
13.64Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.64Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.64Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
13.64Consensusa3_on_gpOrthosteric Liganda3a_on_gp
13.64Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.64Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.64Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.64Consensusbombesin_offOrthosteric Ligandbb2_off
13.64Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
13.64Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
13.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
13.33Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
13.33Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
13.33Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
13.33Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.33Single8ZRTET-18ZRT-ETB-ET-1
13.33Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
13.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
13.33Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
13.16Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.16Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.04Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
13.04Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
13.04Single5V57TC1145V57-SMO-TC114
13.04Single5XRAAM115425XRA-CB1-AM11542
13.04Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
13.04Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
13.04Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
13.04Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.04Single7FEECP559407FEE-CB1-CP55940-ZCZ011
13.04Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
13.04Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
13.04Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
13.04Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
13.04Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
13.04Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
13.04Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
13.04Single8E0GBU728E0G-μ-BU72
13.04Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.04Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.04Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
13.04Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
13.04Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
13.04Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.04Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
13.04Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.04Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
13.04Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
13.04Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.04Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusa2_onOrthosteric Liganda2b_on
13.04Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.04Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.04Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.04Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
13.04Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.04Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.04Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.04Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusrelaxin_onOrthosteric Ligandrxfp4_on
13.04Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
13.04Consensustachykinin_offOrthosteric Ligandnk1_off
12.90Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
12.90Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
12.90Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
12.90Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.90Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
12.90Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
12.50Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
12.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
12.50Single6KQICP559406KQI-CB1-CP55940-Org27569
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
12.50Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
12.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.50Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
12.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
12.50Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
12.50Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
12.50Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
12.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.50Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.50Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
12.50Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
12.50Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
12.50Consensuslpa_offOrthosteric Ligandlpa1_off
12.50Consensuslpl_offOrthosteric Ligands1p_off lpa_off
12.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
12.50Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
12.50Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.50Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.12Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
12.12Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
12.12Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.12Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.12Consensusbradykinin_onOrthosteric Ligandbk2_on
12.12Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
12.12Consensusendothelin_onOrthosteric Ligandetb_on eta_on
12.12Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
12.12Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
12.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7EZCUKA7EZC-A2A-UKA
12.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
12.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
12.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
12.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
12.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
12.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
12.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.76Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.76Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
11.76Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.76Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Consensusp2y_offOrthosteric Ligandp2y1_off
11.54Single3NY9ICI118-5513NY9-β2-ICI118-551
11.54Single4UG2CGS216804UG2-A2A-CGS21680
11.54Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
11.54Single5WF6UK-4320975WF6-A2A-UK-432097
11.54Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.54Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
11.54Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.54Single6PT3DPI-2876PT3-δ-DPI-287
11.54Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.54Single7XN9L-054,5227XN9-SST2-L-054,522
11.54Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
11.54Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
11.54Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
11.54Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
11.54Single8XQJJN2418XQJ-Apelin-JN241
11.54Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.54Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
11.54Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
11.54Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.54Consensuskisspeptin_onOrthosteric Ligandkiss1_on
11.54Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.54Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.43Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
11.43Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
11.43Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.36Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.11Single3UZAGTPL92363UZA-A2A-GTPL9236
11.11Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7QA8Peptide7QA8-STE2-Peptide
11.11Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
11.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
11.11Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
11.11Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.11Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
11.11Single8IEIA1LYA8IEI-GPR156-A1LYA
11.11Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.11Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
11.11Single8JPSCCL78JPS-ACKR1-CCL7
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
11.11Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
11.11Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
11.11Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
11.11Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
11.11Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.11Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
11.11Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.11Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.11Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
11.11Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.11Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.11Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.11Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.81Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
10.81Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
10.81Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single6HLOAprepitant6HLO-NK1-Aprepitant
10.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.71Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.71Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
10.71Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
10.71Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
10.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.53Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.53Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
10.53Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.53Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
10.53Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
10.53Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.53Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34Single5WF5UK-4320975WF5-A2A-UK-432097
10.34Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.34Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.34Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
10.34Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
10.34Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
10.34Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
10.34Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single4QINSAG1.54QIN-SMO-SAG1.5
10.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.00Single6B73MP11046B73-κ-MP1104
10.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.00Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
10.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
10.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
10.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
10.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
10.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
10.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
10.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
10.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
10.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
10.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
10.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
10.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
9.68Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
9.68Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
9.68Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.68Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.68Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
9.68Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
9.68Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
9.68Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
9.68Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
9.68Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
9.68Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.68Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
9.68Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.52Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
9.52Single6IQLL7458706IQL-D4-L745870
9.52Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.52Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
9.52Single6TPGEMPA6TPG-OX2-EMPA
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.52Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single7T32ZM-2413857T32-A2A-ZM-241385
9.52Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
9.52Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
9.52Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.52Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.52Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.52Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
9.52Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8K2WAMG4878K2W-CXCR3-AMG487
9.52Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
9.52Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.52Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.52Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.52Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.52Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.52Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
9.52Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
9.52Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.38Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.38Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
9.38Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.38Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
9.38Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.38Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.09Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.09Single4EJ4Naltrindole4EJ4-δ-Naltrindole
9.09Single4YAYZD-71554YAY-AT1-ZD-7155
9.09Single5DHGC-355DHG-NOP-C-35
9.09Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
9.09Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
9.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
9.09Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
9.09Single6PS1Timolol6PS1-β2-Timolol
9.09Single6TOTLemborexant6TOT-OX1-Lemborexant
9.09Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.09Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
9.09Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
9.09Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
9.09Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
9.09Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.09Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
9.09Single7UL4Alvimopan7UL4-μ-Alvimopan
9.09Single7V3ZCP559407V3Z-CB1-CP55940
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
9.09Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
9.09Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
9.09Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.09Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
9.09Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.09Single8RLNLUF58348RLN-A2A-LUF5834
9.09Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.09Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
9.09Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.09Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
9.09Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
9.09Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.09Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.09Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.09Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
8.82Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
8.82Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
8.82Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
8.82Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
8.70Single5C1MBU725C1M-μ-BU72
8.70Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
8.70Single5XPRBosentan5XPR-ETB-Bosentan
8.70Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.70Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.70Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.70Single7C61Ergotamine7C61-5-HT1B-Ergotamine
8.70Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
8.70Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
8.70Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.70Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
8.70Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
8.70Single7WC6LSD7WC6-5-HT2A-LSD
8.70Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
8.70Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
8.70Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
8.70Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
8.70Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
8.70Single8JXSPF-61428JXS-D1-PF-6142
8.70Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
8.70Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
8.70Single8S4DCMF-0198S4D-Apelin-CMF-019
8.70Single8TF5Oleic acid8TF5-GPR6-Oleic acid
8.70Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.70Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
8.70Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
8.70Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
8.70Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
8.70Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.70Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
8.70Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
8.70Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
8.70Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
8.57Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
8.57Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
8.33Single3P0GBI1671073P0G-β2-BI167107
8.33Single4DJHJDTic4DJH-κ-JDTic
8.33Single5XR8AM8415XR8-CB1-AM841
8.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
8.33Single6J21Aprepitant6J21-NK1-Aprepitant
8.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
8.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
8.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
8.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
8.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
8.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
8.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
8.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
8.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
8.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
8.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
8.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
8.33Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
8.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.33Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
8.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.33Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
8.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
8.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
8.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.33Single8XVLZibotentan8XVL-ETA-Zibotentan
8.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
8.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.33Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
8.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
8.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
8.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.33Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
8.11Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
8.11Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.11Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
8.00Single4LDEBI1671074LDE-β2-BI167107
8.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
8.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
8.00Single6MXTSalmeterol6MXT-β2-Salmeterol
8.00Single6OS2TRV0266OS2-AT1-TRV026
8.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
8.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
8.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
8.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
8.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
8.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
8.00Single8JJ8Formoterol8JJ8-β2-Formoterol
8.00Single8JJLOlodaterol8JJL-β2-Olodaterol
8.00Single8JWY2-1188JWY-A2A-2-118
8.00Single8JWZAB9288JWZ-A2A-AB928-Na
8.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
8.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
8.00Single8XQJJN2418XQJ-Apelin-JN241
8.00Single8XYIVUF106618XYI-CXCR3-VUF10661
8.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
8.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
8.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
8.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
8.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
8.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
8.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
8.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
8.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.69Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
7.69Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
7.69Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
7.69Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
7.69Single5X93K-87945X93-ETB-K-8794
7.69Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
7.69Single6K1QIRL25006K1Q-ETB-IRL2500
7.69Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
7.69Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
7.69Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
7.69Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.69Single7UM4AS26747237UM4-5-HT5A-AS2674723
7.69Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
7.69Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
7.69Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
7.69Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.69Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
7.69Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
7.69Consensuschemerin_onOrthosteric Ligandcml1_on
7.69Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
7.69Consensusendothelin_offOrthosteric Ligandetb_off
7.69Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
7.69Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.41Single5ZTYAM102575ZTY-CB2-AM10257
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.41Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
7.41Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
7.41Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.41Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
7.41Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.41Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
7.41Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
7.41Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
7.41Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
7.41Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
7.41Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
7.41Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
7.14Single4IARErgotamine4IAR-5-HT1B-Ergotamine
7.14Single4XT1Fractalkine4XT1-US28-Fractalkine
7.14Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
7.14Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.14Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
7.14Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
7.14Single8WDTphotoNECA8WDT-A2A-photoNECA
7.14Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.14Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
6.90Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
6.90Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
6.90Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
6.90Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
6.90Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.90Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
6.90Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
6.90Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
6.90Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
6.90Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
6.90Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
6.90Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
6.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
6.45Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
6.45Single6JODAngiotensin II6JOD-AT2-Angiotensin II
6.45Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.45Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.45Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
6.45Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
6.45Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
6.25Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.25Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
6.25Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
6.25Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
6.06Single4XT3Fractalkine4XT3-US28-Fractalkine
6.06Single6FJ3PTH6FJ3-PTH1-PTH
6.06Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
6.06Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.06Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
6.06Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.06Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
5.88Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
5.88Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
5.88Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
5.88Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
5.88Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
5.88Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
5.88Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
5.88Single8PWNTheophylline8PWN-A2A-Theophylline
5.88Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
5.88Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.71Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
5.71Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
5.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.71Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
5.56Single3OE8IT1t3OE8-CXCR4-IT1t
5.56Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.56Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
5.56Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
5.41Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
5.26Single3OE6IT1t3OE6-CXCR4-IT1t
5.26Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.26Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.26Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
5.26Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.26Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
5.26Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
5.26Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.26Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.26Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.26Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.26Consensus5ht2_onOrthosteric Ligand5ht2b_on
5.26Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.26Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.13Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.13Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.13Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.00Single3OE9IT1t3OE9-CXCR4-IT1t
5.00Single3PBLEticlopride3PBL-D3-Eticlopride
5.00Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
5.00Single7SRQLSD7SRQ-5-HT2B-LSD
5.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
5.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
5.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
5.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
5.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.00Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
5.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
5.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
5.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
4.76Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
4.76Single3ODUIT1t3ODU-CXCR4-IT1t
4.76Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.76Single6AKXA4R6AKX-CCR5-A4R
4.76Single6DS0Ly2660976DS0-5-HT2B-Ly266097
4.76Single6ME2Ramelteon6ME2-MT1-Ramelteon
4.76Single6ME9Ramelteon6ME9-MT2-Ramelteon
4.76Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
4.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.76Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
4.76Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
4.76Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
4.76Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
4.76Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
4.76Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
4.76Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
4.76Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
4.76Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
4.76Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
4.76Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.76Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
4.76Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
4.76Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
4.76Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
4.76Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
4.76Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
4.76Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
4.76Single8IWESpermidine8IWE-TA9-Spermidine
4.76Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
4.76Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
4.76Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
4.76Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
4.76Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
4.76Single8Y0HVUF114188Y0H-CXCR3-VUF11418
4.76Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
4.76Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
4.76Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
4.76Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.76Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
4.76Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
4.76Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
4.76Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
4.76Consensusalpha2_offOrthosteric Ligandalpha2c_off
4.76Consensusangiotensin_offOrthosteric Ligandat1_off
4.76Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
4.76Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
4.76Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.55Single2YDOAdenosine2YDO-A2A-Adenosine
4.55Single3RZECidoxepin3RZE-H1-Cidoxepin
4.55Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.55Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
4.55Single4MBSMaraviroc4MBS-CCR5-Maraviroc
4.55Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.55Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
4.55Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
4.55Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
4.55Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
4.55Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
4.55Single6PS0S-Carazolol6PS0-β2-S-Carazolol
4.55Single6PS4ICI118-5516PS4-β2-ICI118-551
4.55Single6PS5S-Propranolol6PS5-β2-S-Propranolol
4.55Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.55Single6VI4JDTic6VI4-κ-JDTic
4.55Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
4.55Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.55Single6ZG9GSK10347026ZG9-M1-GSK1034702
4.55Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
4.55Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
4.55Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
4.55Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
4.55Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
4.55Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
4.55Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
4.55Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
4.55Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
4.55Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
4.55Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.55Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
4.55Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
4.55Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
4.55Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
4.55Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
4.55Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
4.55Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
4.55Single8IHKAcifran8IHK-HCA3-Acifran
4.55Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
4.55Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
4.55Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
4.55Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
4.55Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
4.55Single8K5CAcipimox8K5C-HCA2-Acipimox
4.55Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
4.55Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
4.55Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
4.55Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.55Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
4.55Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
4.55Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
4.55Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
4.55Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
4.55Consensusalpha1_onOrthosteric Ligandalpha1a_on
4.55Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
4.55Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.55Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
4.55Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.55Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
4.55Consensushca_onOrthosteric Ligandhca2_on
4.35Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
4.35Single2Y02Carmoterol2Y02-β1-Carmoterol
4.35Single2Y04Salbutamol2Y04-β1-Salbutamol
4.35Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
4.35Single3NY8ICI118-5513NY8-β2-ICI118-551
4.35Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
4.35Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.35Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.35Single4GBRS-Carazolol4GBR-β2-S-Carazolol
4.35Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
4.35Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
4.35Single5DHHSB-6121115DHH-NOP-SB-612111
4.35Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
4.35Single5TGZAM65385TGZ-CB1-AM6538
4.35Single6D27CAY104716D27-DP2-CAY10471
4.35Single6DRXLisuride6DRX-5-HT2B-Lisuride
4.35Single6GPSMK08126GPS-CCR2-MK0812
4.35Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.35Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.35Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
4.35Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
4.35Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.35Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
4.35Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
4.35Single7BU7BI1671077BU7-β1-BI167107
4.35Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
4.35Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.35Single7F83PF-051904577F83-Ghrelin-PF-05190457
4.35Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
4.35Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
4.35Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
4.35Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
4.35Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.35Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
4.35Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.35Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
4.35Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
4.35Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
4.35Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.35Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.35Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
4.35Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.35Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.35Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
4.35Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
4.35Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
4.35Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
4.35Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
4.35Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
4.35Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
4.35Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
4.35Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
4.35Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.35Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.35Single8JJOAlprenolol8JJO-β2-Alprenolol
4.35Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
4.35Single8JXRLSD8JXR-D1-LSD
4.35Single8K5DGSK2560738K5D-HCA2-GSK256073
4.35Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.35Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35Single8X63Mepyramine8X63-H1-Mepyramine
4.35Single8X64Desloratadine8X64-H1-Desloratadine
4.35Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.35Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
4.35Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
4.35Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
4.35Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
4.35Single9CHXS-Carazolol9CHX-β2-S-Carazolol
4.35Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.35Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
4.35Consensus5ht5_onOrthosteric Ligand5ht5a_on
4.35Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.35Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.35Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.35Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
4.35Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
4.35Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
4.35Consensusalpha2_onOrthosteric Ligandalpha2b_on
4.35Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
4.35Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.35Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.35Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.35Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Consensusblt_onOrthosteric Ligandblt1_on
4.35Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
4.35Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.35Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.35Consensusdopamine_offOrthosteric Ligandd2_off d3_off
4.35Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
4.35Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
4.35Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
4.35Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.35Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.35Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
4.35Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.35Consensushca_on_gpOrthosteric Ligandhca2_on_gp
4.35Consensushistamine_offOrthosteric Ligandh1_off
4.35Consensusleukotriene_onOrthosteric Ligandblt_on
4.35Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
4.35Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.17Single2RH1S-Carazolol2RH1-β2-S-Carazolol
4.17Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.17Single2YCWS-Carazolol2YCW-β1-S-Carazolol
4.17Single5D6LS-Carazolol5D6L-β2-S-Carazolol
4.17Single5JQHS-Carazolol5JQH-β2-S-Carazolol
4.17Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.17Single5TVNLSD5TVN-5-HT2B-LSD
4.17Single6E67BI1671076E67-β2-BI167107-Gs (fused)
4.17Single6GPXMK08126GPX-CCR2-MK0812
4.17Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
4.17Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
4.17Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.17Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.17Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
4.17Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.17Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
4.17Single6PS6Timolol6PS6-β2-Timolol
4.17Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
4.17Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
4.17Single7C4SS1P7C4S-S1P3-S1P
4.17Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
4.17Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.17Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
4.17Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
4.17Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
4.17Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.17Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
4.17Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.17Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
4.17Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
4.17Single8ZMFA1L108ZMF-5-HT2C-A1L10
4.17Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.17Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
4.17Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
4.17Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
4.17Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.17Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.17Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.17Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
4.17Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.17Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
4.17Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
4.17Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
4.17Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
4.17Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.17Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.17Consensusamine_offonOrthosteric Ligandamine_off amine_on
4.17Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
4.17Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.17Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
4.17Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.17Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
4.17Consensusblt_offOrthosteric Ligandblt1_off
4.17Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
4.17Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.17Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
4.17Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
4.17Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.17Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
4.00Single2YDVNECA2YDV-A2A-NECA
4.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
4.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
4.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.00Single4UHRCGS216804UHR-A2A-CGS21680
4.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
4.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
4.00Single5G53NECA5G53-A2A-NECA-Gs
4.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
4.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.00Single6OS1TRV0266OS1-AT1-TRV026
4.00Single6WGTLSD6WGT-5-HT2A-LSD
4.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
4.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
4.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.00Single7P2L4YI7P2L-mGlu5-4YI
4.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
4.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
4.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
4.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
4.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
4.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
4.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
4.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
4.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
4.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.00Single9BJKNAM9BJK-μ-Naloxone-NAM
4.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
4.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
4.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.85Single3D4STimolol3D4S-β2-Timolol
3.85Single4AMIBucindolol4AMI-β1-Bucindolol
3.85Single4N4WSANT-14N4W-SMO-SANT-1
3.85Single5X33BIIL2605X33-BLT1-BIIL260
3.85Single6A93Risperidone6A93-5-HT2A-Risperidone
3.85Single6CM4Risperidone6CM4-D2-Risperidone
3.85Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
3.85Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
3.85Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.85Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.85Single6ZG4HTL00099366ZG4-M1-HTL0009936
3.85Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
3.85Single7DFPSpiperone7DFP-D2-Spiperone
3.85Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
3.85Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
3.85Single7K15MKD0467K15-BLT1-MKD046-Na
3.85Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
3.85Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
3.85Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
3.85Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
3.85Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
3.85Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
3.85Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
3.85Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
3.85Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
3.85Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
3.85Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
3.85Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.85Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
3.85Consensusalpha1_offOrthosteric Ligandalpha1a_off
3.85Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
3.85Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
3.85Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
3.85Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
3.85Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
3.85Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.70Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
3.70Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
3.70Single6H7LDobutamine6H7L-β1-Dobutamine
3.70Single6IBLArformoterol6IBL-β1-Arformoterol
3.70Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.70Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
3.70Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.70Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
3.70Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
3.70Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
3.70Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.70Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
3.70Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
3.70Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
3.70Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.70Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
3.70Single8XVJMacitentan8XVJ-ETA-Macitentan
3.70Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.70Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
3.70Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
3.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
3.57Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
3.57Single8X5YAstemizole8X5Y-H1-Astemizole
3.57Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.45Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
3.45Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.45Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
3.45Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
3.45Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
3.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
3.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.23Consensusangiotensin_onOrthosteric Ligandat1_on
3.23Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.12Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
3.12Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.12Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
3.12Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.12Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.12Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.12Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.12Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
3.12Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.12Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
3.03Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.03Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
3.03Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
2.94Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.86Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.86Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
2.86Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.78Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.78Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.78Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.78Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.78Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.63Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.63Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.27Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.22Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3

PDB Summary
PDB 8JGF
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRX1
Species Homo Sapiens
Ligand BAM8-22
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.7
Date 2024-01-10
D.O.I. 10.1038/s41467-023-40705-z
Net Summary
Imin 4.03
Number of Linked Nodes 829
Number of Links 998
Number of Hubs 158
Number of Links mediated by Hubs 579
Number of Communities 25
Number of Nodes involved in Communities 220
Number of Links involved in Communities 325
Path Summary
Number Of Nodes in MetaPath 116
Number Of Links MetaPath 115
Number of Shortest Paths 2894393
Length Of Smallest Path 3
Average Path Length 45.5776
Length of Longest Path 78
Minimum Path Strength 1.35
Average Path Strength 8.1878
Maximum Path Strength 29.5
Minimum Path Correlation 0.7
Average Path Correlation 0.985583
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.66667
Average % Of Corr. Nodes 29.6594
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.41
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8JGF_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RRTLRLLLL GADNSGKST 
IVKQMRTSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVDSS DYNRLQEAL NDFKSIWNN RWLRTISVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
KEFVDISTA SGDGRHICY PHFTCSVDT ENARRIFND CKDIILQMN 
LREYNLV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JGF_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JGF_Chain_G
AQARKLVEQ LKMEANIDR IKVSKAAAD LMAYCEAHA KEDPLLTPV 
PASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96LB2
Sequence
>8JGF_Chain_R
YKQTLSLTV LTCIVSLVG LTGNAVVLW LLGCRMRRN AFSIYILNL 
AAADFLFLS GRLIYSLLS SKILYPVMM FSYFAGLSF LSAVSTERC 
LSVLWPIWY RCHRPTHLS AVVCVLLWA LSLLRSILE WMLCQTSDF 
ITVAWLIFL CVVLCGSSL VLLIRILCG SRKIPLTRL YVTILLTVL 
VFLLCGLPF GIQFFLFLW IHVDREVLF CHVHLVSIF LSALNSSAN 
PIIYFFVGS FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JGFAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ22.72024-01-1010.1038/s41467-023-40705-z
8JGF (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-2.72024-01-1010.1038/s41467-023-40705-z
8JGGAOrphanOrphanMRGPRX1Homo sapiensBAM8-22-Gi1/β1/γ232024-01-1010.1038/s41467-023-40705-z
8JGG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensBAM8-22-32024-01-1010.1038/s41467-023-40705-z
8JGBAOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-Gi1/β1/γ22.842024-01-1010.1038/s41467-023-40705-z
8JGB (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensConorfamide-Tx2-2.842024-01-1010.1038/s41467-023-40705-z
8HJ5AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ232023-05-3110.1371/journal.pbio.3001975
8HJ5 (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-32023-05-3110.1371/journal.pbio.3001975
8DWHAOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ23.252022-11-0210.1038/s41589-022-01173-6
8DWH (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensPubChem 139030531-3.252022-11-0210.1038/s41589-022-01173-6
8DWGAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML382chim(NtGi2L-Gs-CtGq)/β1/γ22.712022-11-0210.1038/s41589-022-01173-6
8DWG (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-AML3822.712022-11-0210.1038/s41589-022-01173-6
8DWCAOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ22.872022-11-0210.1038/s41589-022-01173-6
8DWC (No Gprot) AOrphanOrphanMRGPRX1Homo sapiensProenkephalin-A-2.872022-11-0210.1038/s41589-022-01173-6




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