Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x39 3.8575406
21x43 5.058527
31x53 3.595419
41x57 3.7125417
5I1 7.82667616
62x38 7.86446
72x39 2.975407
82x42 3.77667647
92x44 3.84416
102x45 7.04449
112x50 6.754529
122x53 3.99714727
132x54 4.455427
142x55 3.6675425
152x56 6.31427
162x57 9.62427
172x60 6.99426
18E1x50 8.486528
193x24 4.545425
203x29 9.8125425
213x30 5.1175405
223x33 5.0375405
233x38 6.3625447
243x41 3.7775405
253x46 5.705448
263x50 8.465449
273x51 4.348508
283x54 5.0275408
294x46 3.86447
304x50 7.475449
314x53 3.2975448
32E2 21.23311323
33E2x50 8.2575429
345x47 5.8625148
355x50 2.77549
365x58 5.454549
375x65 4.9625408
385x69 4.2725153
396x44 3.288549
406x48 8.258528
416x59 10.055425
42E3 10.0133622
437x27 3.37424
447x31 6.35424
457x34 6.61167624
467x38 8.1825425
477x42 8.08333627
487x53 5.764549
497x55 3.815416
508x50 6.02518
51G.HN.43 3.1475469
52G.S1.02 6.23435
53G.S1.05 4.754519
54G.S1.06 6.6475438
55G.S1.07 3.42419
56G.s1h1.04 7.244169
57G.H1.01 6.695439
58G.H1.04 4.482537
59G.S2.01 5.87419
60G.S2.06 5.3525439
61G.S2.08 8.3854135
62G.S3.05 4.9875437
63G.S3.06 7.844515
64G.s3h2.03 5.5025419
65G.H2.02 4.6875418
66G.H2.03 6.11419
67G.H2.06 6.38429719
68G.H2.07 5.5519
69G.H2.09 6.45418
70G.H2.10 4.6925417
71G.h2s4.01 4.63143719
72G.S4.02 5.055418
73G.S4.03 3.47437
74G.S4.04 4.48571719
75G.S4.06 3.41517
76G.s4h3.04 10.67518
77G.s4h3.05 11.305419
78G.H3.01 6.2085169
79G.H3.02 4.072518
80G.H3.09 5.8525409
81G.H3.13 4.40254105
82G.H3.17 7.46667615
83G.H3.18 6.544519
84G.S5.03 3.635638
85G.S5.04 3.998519
86G.S5.05 4.64333639
87G.S5.06 4.86518
88G.HG.04 5.788519
89G.HG.07 7.02419
90G.HG.15 4.625407
91G.hgh4.01 4.7425416
92G.hgh4.02 6.296517
93G.hgh4.05 6.286517
94G.H4.03 7.13167614
95G.H4.05 5.99414
96G.H4.10 9.3225416
97G.H4.11 3.31417
98G.H4.15 3.59714718
99G.h4s6.02 6.4765108
100G.S6.02 5.94667637
101G.S6.04 7.8375439
102G.S6.05 3.586514
103G.s6h5.01 5.148539
104G.s6h5.05 5.3575439
105G.H5.03 6.155438
106G.H5.08 6.666676138
107G.H5.11 4.7525438
108G.H5.13 7.0375408
109G.H5.14 4.145437
110G.H5.16 2.9275406
111G.H5.19 3.615438
112G.H5.20 5.38409
113G.H5.26 4.915605
114b.1x2 3.8675401
115b.h2x1 6.035415
116b.h2x5 4.85415
117b.lhb1x6 4.34667613
118b.lhb1x9 3.088513
119b.lhb1x11 4.342514
120b.l1x3 9.26667669
121b.b2x1 8.706518
122b.b2x3 5.0125406
123b.b2x5 7.734507
124b.b3x4 5.815469
125b.b4x4 9.4825468
126b.b4x6 11.89669
127b.l4x2 10.945484
128b.b5x3 6.73429769
129b.b5x7 5.925497
130b.l5x1 5.1875408
131b.l5x5 9.58857719
132b.b6x3 2.5775408
133b.b6x5 3.7045186
134b.b7x1 6.8325414
135b.l7x2 4.242519
136b.b8x3 4.6875416
137b.b8x4 5.444596
138b.b9x4 5.09409
139b.l9x3 6.516519
140b.l9x6 4.85429718
141b.l9x7 3.426517
142b.b10x5 4.525619
143b.l10x1 3.5575403
144b.b11x2 5.2575417
145b.b11x4 4.9519
146b.l11x2 6.205419
147b.b12x3 3.46478
148b.b12x6 8.56833618
149b.l12x3 4.02405
150b.b13x7 7.804577
151b.l13x3 7.92679
152b.l13x7 3.9125479
153b.b15x1 7.055479
154b.b15x2 5.084556
155b.b15x3 4.2975479
156b.l15x1 4.796517
157b.l15x2 4.3375479
158b.b16x4 12.555476
159b.b16x5 3.4575455
160b.b16x6 9.145678
161b.l16x3 6.21754113
162b.b17x7 7.805458
163b.l17x3 9.78571759
164b.l17x6 6.7625419
165b.b18x3 3.536558
166b.b18x5 5.00167655
167b.l18x1 5.89716
168b.l18x2 4.945417
169b.l18x3 11.6675415
170b.b19x2 6.805656
171b.b19x4 5.784558
172b.l19x1 4.986519
173b.l19x2 5.21167659
174b.b20x4 10.0833658
175b.b20x5 3.695417
176b.b20x6 7.30667656
177b.b20x7 3.67409
178b.b21x1 8.485457
179b.b21x2 3.3825406
180b.b21x5 5.154514
181b.b21x7 5.09571715
182b.b22x5 5.365617
183b.l22x5 7.852519
184b.b23x6 6.05167617
185b.l23x1 8.265416
186b.l23x2 7.08418
187b.b24x4 4.858516
188b.b24x6 6.0325418
189b.b25x3 6.3675415
190b.b25x6 3.4825413
191b.l25x3 8.06519
192b.l25x6 10.6025418
193b.l26x5 5.07485
194b.b27x3 4.776518
195b.l27x1 9.99429719
196b.b28x2 5.105414
197b.b28x3 4.82567
198b.b28x4 8.1125416
199b.b28x6 7.93167619
200g.h2x9 3.355414
201g.ctx3 6.644509
202g.ctx4 3.0325407
203g.ctx6 3.046516
204g.ctx15 6.3325489
205g.ctx16 5.45571788
206Lig 13.41691320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
12x60 Lig 37.31699.02YesYes260
22x56 2x60 19.0426.1YesYes276
32x53 2x56 19.31555.38YesYes277
42x53 7x46 48.53733.82YesNo279
52x50 7x46 51.118810.31YesNo299
62x46 2x50 56.6195.43NoYes099
72x46 3x43 29.64972.77NoNo098
83x43 7x53 33.41985.86NoYes089
92x60 7x42 19.02627.89YesYes267
102x53 7x42 24.92692.98YesYes277
112x46 3x42 27.55044.42NoNo097
122x42 3x42 28.30062.59YesNo077
132x42 3x46 34.31273.73YesYes478
142x43 3x46 85.66944.37NoYes088
151x57 2x43 90.54342.85YesNo078
163x46 7x53 31.44974.79YesYes489
171x57 2x44 96.03824.15YesYes176
182x44 I1 98.85912.43YesYes166
19I1 b.b28x2 99.5673.01YesYes164
20E2 Lig 16.543722.65YesYes230
213x50 G.H5.25 23.0688.5YesNo097
226x33 G.H5.25 18.89972.95NoNo077
235x65 6x33 16.83124.42YesNo087
245x65 5x69 16.89924.15YesYes083
255x69 G.H5.13 15.90072.71YesYes038
26G.H5.13 G.S6.02 14.907810.34YesYes087
27b.b28x2 b.l27x2 99.96718.36YesNo149
28b.l25x3 b.l27x2 1005.04YesNo199
29b.b27x3 b.l25x3 82.7366.85YesYes189
30b.b26x3 b.b27x3 91.36644.42NoYes068
31b.b22x2 b.b26x3 91.420210.51NoNo086
32b.b22x1 b.b22x2 91.48153.2NoNo088
33b.b22x1 b.l25x6 33.0692.59NoYes188
34G.H3.17 b.l25x6 36.07454YesYes158
35G.H3.15 G.H3.17 46.77197.91NoYes085
36G.H3.15 G.H3.18 46.60434.83NoYes089
37G.H3.18 G.S1.05 23.46252.44YesYes199
38G.S1.05 G.S1.07 23.39385.54YesYes199
39G.S1.07 G.S4.04 45.27912.44YesYes199
40G.H3.18 G.S4.02 22.888110.05YesYes198
41G.S1.07 G.S4.02 22.75162.85YesYes198
42b.b28x6 b.l25x3 17.66635.29YesYes199
43b.b28x6 b.lhb1x11 24.62214.65YesYes194
44b.b28x7 b.lhb1x11 11.91624.21NoYes094
45b.b28x7 g.ctx14 11.714713.62NoNo099
46b.l2x5 b.l4x2 15.195319.55NoYes054
47b.b4x7 b.l2x5 14.59115.48NoNo085
48b.b28x5 g.ctx16 16.41393.77NoYes058
49b.b1x4 b.b28x5 15.82235.01NoNo075
50b.b1x4 b.b5x1 15.24285.17NoNo075
51b.b1x6 b.b5x1 14.66942.95NoNo095
52b.l25x6 b.l27x1 16.911112YesYes189
53G.S5.03 G.S6.02 13.80914.84YesYes387
54b.b22x1 b.l23x1 58.48622.89NoYes186
55b.l21x8 b.l23x1 85.63451.68NoYes046
56b.l19x1 b.l21x8 85.57951.68YesNo094
57G.H2.06 b.l19x1 40.22285.53YesYes199
58G.H2.06 b.l9x6 35.30963.58YesYes198
59G.H2.02 b.l9x6 18.15315.09YesYes188
60G.H2.02 G.H2.07 23.34994.94YesYes189
61G.H2.06 b.l15x1 10.1914.85YesYes197
62G.H2.04 G.H2.07 22.38188NoYes099
63G.H3.08 G.S4.04 21.54196.09NoYes199
64G.S4.04 G.S4.06 30.05382.62YesYes197
65G.S4.04 G.S5.04 26.61183.65YesYes199
66G.H4.15 G.S4.06 16.57925.24YesYes187
67G.H4.15 G.S5.04 16.59244.87YesYes189
68G.H4.11 G.H4.15 20.15893.77YesYes178
69G.HG.04 G.s4h3.04 12.53226.19YesYes198
70G.H4.11 G.HG.15 11.81732.85YesYes077
71b.l17x5 b.l19x1 95.62792.94NoYes069
72b.l17x5 b.l19x2 95.51994.42NoYes069
73b.l17x3 b.l19x2 66.67172.52YesYes599
74b.b19x4 b.l17x3 38.685510.95YesYes589
75b.b18x3 b.b19x4 13.31483.04YesYes588
76b.b15x2 b.b18x3 12.65874.61YesYes568
77b.b15x2 b.b16x5 46.55954.47YesYes565
78b.b16x5 b.l14x6 80.3254.15YesNo053
79b.b16x7 b.l14x6 79.13335.43NoNo093
80b.b16x7 b.l16x3 40.769311.69NoYes1193
81b.b17x2 b.l16x3 35.98612.71NoYes1133
82b.b17x2 g.h1x13 69.56692.89NoNo031
83g.h1x13 g.h1x9 67.17111.35NoNo016
84g.h1x12 g.h1x9 64.77511.35NoNo066
85b.1x6 g.h1x12 33.58862.7NoNo1786
86b.1x2 b.1x6 31.2083.82YesNo018
87b.b19x2 b.b19x4 25.25522.59YesYes568
88b.b15x2 b.b19x2 37.99265.24YesYes566
89b.b20x6 b.l17x3 27.60784.53YesYes569
90b.b19x2 b.b20x6 50.507812.86YesYes566
91b.b20x4 b.l19x2 28.06255.96YesYes589
92b.b20x4 b.b20x6 27.62728.55YesYes586
93b.b19x2 b.l20x1 37.47962.44YesNo566
94b.b16x5 b.l20x1 34.91962.77YesNo556
95b.b16x7 b.b17x4 37.17213.1NoNo1195
96b.b17x2 b.b17x4 35.976212.41NoNo1135
97b.1x2 b.1x3 24.00943.99YesNo018
98b.1x3 g.h1x4 21.60954.73NoNo085
99b.ntx3 g.h1x4 16.80891.58NoNo045
100g.h1x12 g.h1x8 28.79024.55NoNo1767
101b.1x10 g.h1x8 26.40921.49NoNo087
102b.1x10 g.h1x11 19.20932.77NoNo089
103b.1x11 g.h1x11 14.40825.64NoNo069
104b.lhb1x6 b.lhb1x9 10.29893.07YesYes133
105b.l11x1 b.l9x6 20.08244.35NoYes198
106b.b11x6 b.l11x1 22.453.71NoNo199
107b.b11x6 b.l9x3 21.835712.55NoYes199
108b.b11x4 b.l9x3 15.11742.74YesYes199
109b.b26x1 b.l27x1 30.25714.94NoYes099
110b.b26x1 b.b26x2 30.04893.44NoNo097
111b.b26x2 b.b2x3 29.68354.86NoYes076
112b.l4x1 g.ctx16 14.00193.96NoYes858
113b.b2x5 b.l4x1 25.79874.94YesNo075
114b.l13x5 b.l15x1 19.91211.96NoYes057
115b.b15x5 b.l13x5 18.03151.95NoNo085
116b.b15x5 b.l13x3 15.11095.85NoYes789
117b.l21x7 b.l23x1 20.43654.67NoYes156
118b.b23x6 b.l21x7 15.1174.03YesNo175
119b.b23x6 b.b24x6 11.15715.79YesYes178
120b.b21x7 b.b24x6 11.24914.82YesYes158
1213x46 3x50 20.8539.93YesYes489
122G.H3.17 b.l27x1 11.58462.81YesYes159
123b.l4x1 b.l4x2 11.41483.82NoYes854
124G.H2.04 G.H3.08 21.6494.86NoNo099
125b.l23x1 b.l25x6 19.974423.82YesYes168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x311x326.572NoNo6512
1x311x333.52NoNo6512
1x321x338.462NoNo5522
1x357x312.592NoYes5421
1x357x359.122NoNo5422
2x562x606.12YesYes7621
2x567x425.382YesYes7722
2x607x384.952YesYes6512
2x607x427.892YesYes6712
2x60Lig9.022YesYes6010
2x63E1x502.452NoYes4812
2x63Lig9.72NoYes4010
2x647x343.092NoYes4411
2x647x388.712NoYes4512
2x64Lig3.822NoYes4010
3x25E1x505.222NoYes9822
E1x50E2x5018.282YesYes8922
3x22E23.150NoYes2321
3x25E25.132NoYes9321
3x25E2x507.282NoYes9922
3x283x296.632NoYes5521
3x294x6517.312YesNo5412
3x29E2x504.422YesYes5912
3x29Lig10.892YesYes5010
4x64E237.962NoYes5321
4x65E2x503.052NoYes4922
4x65E2x5215.292NoNo4422
E2E265.262YesYes3311
E2E2x5128.062YesNo3511
E2Lig22.652YesYes3010
E2x51Lig11.832NoYes5010
E2E2x524.362YesNo3412
5x36E227.852NoYes4321
5x39E26.752NoYes5321
5x32E26.442NoYes5321
6x516x5519.112NoNo6522
6x517x343.392NoYes6421
6x547x343.760NoYes5421
6x557x346.772NoYes5421
6x57E38.060NoYes4221
6x58Lig4.730NoYes3010
E3E34.332YesYes2211
7x30E311.952NoYes3221
E3Lig26.162YesYes2010
7x27E35.252YesYes4221
7x277x304.82YesNo4322
7x317x3510.052YesNo4412
7x31Lig11.542YesYes4010
7x347x3815.82YesYes4512
7x34Lig6.862YesYes4010
7x387x423.272YesYes5722
3x26E21.740NoYes6321
1x31Lig1.642NoYes6010
E1x49E21.422NoYes4321
7x317x321.222YesNo4112

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
100.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
100.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
71.43Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
66.67Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
66.67Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
66.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
66.67Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
63.64Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
61.54Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
61.54Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
60.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
58.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
57.14Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
56.25Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
56.25Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
56.25Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
52.94Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
47.06Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
47.06Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
47.06Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
47.06Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
47.06Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
47.06Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
47.06Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
46.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
46.15Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
46.15Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
46.15Consensusgq_nucleotideOrthosteric Ligandgq_p2y
46.15Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
45.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
44.44Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
43.48Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
42.86Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
42.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
42.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.11Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
41.67Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
41.67Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
41.67Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
41.18Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
41.18Single6OS1TRV0266OS1-AT1-TRV026
41.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
41.18Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
41.18Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
41.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
41.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
41.18Consensusneurotensin_onOrthosteric Ligandnts1_on
41.18Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
40.91Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
40.91Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
40.91Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
40.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
40.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
40.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
40.00Single8XWNCXCL88XWN-CXCR2-CXCL8
40.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
40.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
40.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
40.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
38.89Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
38.89Single4XEENeurotensin4XEE-NTS1-Neurotensin
38.89Single4XESNeurotensin4XES-NTS1-Neurotensin
38.89Single6OS2TRV0266OS2-AT1-TRV026
38.89Single6YVRNTS8-136YVR-NTS1-NTS8-13
38.89Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
38.89Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
38.89Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
38.89Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.46Single3OE6IT1t3OE6-CXCR4-IT1t
38.46Single4XNWMRS25004XNW-P2Y1-MRS2500
38.46Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
38.46Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
38.10Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
38.10Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
38.10Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
38.10Single7XNACYN1548067XNA-SST2-CYN154806
38.10Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
38.10Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
38.10Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.10Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
38.10Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.10Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
38.10Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
37.50Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
37.50Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
37.50Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.50Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
37.50Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
37.50Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.50Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
36.84Single4BUONeurotensin4BUO-NTS1-Neurotensin
36.84Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
36.84Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
36.84Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.84Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
36.84Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
36.84Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
36.84Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
36.84Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.84Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
36.84Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.84Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.36Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.36Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
36.36Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
36.36Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
36.36Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.36Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
36.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
36.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.71Single3OE9IT1t3OE9-CXCR4-IT1t
35.29Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
35.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
35.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
35.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
35.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
35.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
35.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
35.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
35.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
35.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
35.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
35.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.78Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.78Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
34.78Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
34.62Single6IGLIRL16206IGL-ETB-IRL1620
33.33Single3ODUIT1t3ODU-CXCR4-IT1t
33.33Single4BV0Neurotensin4BV0-NTS1-Neurotensin
33.33Single4BWBNeurotensin4BWB-NTS1-Neurotensin
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
33.33Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
33.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
33.33Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
33.33Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
33.33Single8ZRTET-18ZRT-ETB-ET-1
33.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
33.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
33.33Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
33.33Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
33.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
33.33Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
33.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Consensusrelaxin_onOrthosteric Ligandrxfp4_on
33.33Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
33.33Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.14Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
32.14Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
32.00Single4XT3Fractalkine4XT3-US28-Fractalkine
32.00Single7SK3CXCL127SK3-ACKR3-CXCL12
32.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
32.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
32.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
32.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
31.82Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
31.82Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
31.82Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
31.82Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.82Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.82Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.82Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.82Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.82Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.82Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
31.58Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.58Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.58Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
31.58Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
31.58Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
31.58Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
31.58Single8XWACXCL18XWA-CXCR2-CXCL1
31.58Single8XWMCXCL68XWM-CXCR2-CXCL6
31.58Single8XWSCXCL58XWS-CXCR2-CXCL5
31.25Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
31.25Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
31.25Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.25Single8IHKAcifran8IHK-HCA3-Acifran
31.25Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
31.25Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
31.25Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
31.25Consensushca_onOrthosteric Ligandhca2_on
31.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
30.77Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
30.77Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
30.77Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
30.77Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
30.77Consensusp2y_offOrthosteric Ligandp2y1_off
30.43Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.43Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
30.43Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
30.43Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.43Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.43Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.43Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.43Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.43Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
30.43Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
30.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
30.00Single8XVUCXCL28XVU-CXCR2-CXCL2
30.00Single8XWFCXCL38XWF-CXCR2-CXCL3
30.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
30.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
30.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
30.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.63Single8IY6Endothelin-18IY6-ETB-Endothelin-1
29.63Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
29.63Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.63Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
29.41Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
29.41Single5T04Neurotensin5T04-NTS1-Neurotensin
29.41Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
29.41Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
29.41Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.41Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
29.41Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
29.41Single7V3ZCP559407V3Z-CB1-CP55940
29.41Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
29.41Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.41Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.41Single8K5DGSK2560738K5D-HCA2-GSK256073
29.41Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
29.41Consensuscck_offOrthosteric Ligandccka_off
29.41Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
29.41Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.41Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
29.41Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.41Consensushca_on_gpOrthosteric Ligandhca2_on_gp
29.41Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
29.17Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
29.17Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
29.17Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
29.17Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
29.17Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
29.17Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.17Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
29.17Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
28.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.57Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
28.57Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
28.57Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.57Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.57Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.12Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
28.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
28.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
28.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.78Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
27.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
27.78Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
27.78Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
27.78Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
27.78Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.78Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.78Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
27.78Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
27.78Consensusdp_offOrthosteric Liganddp2_off
27.78Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
27.78Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
27.78Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.78Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.59Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
27.59Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.59Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
27.59Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
27.27Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
27.27Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
27.27Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.27Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
27.27Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
27.27Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
27.27Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
27.27Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.27Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.27Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.27Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.27Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
26.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
26.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
26.67Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
26.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.32Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.32Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.32Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
26.32Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.32Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
26.32Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
26.32Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
26.32Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
26.32Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single7SK5CXCL127SK5-ACKR3-CXCL12
26.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
26.09Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
26.09Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
26.09Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
26.09Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.93Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
25.81Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
25.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
25.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
25.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
25.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
25.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
25.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.00Single8XQJJN2418XQJ-Apelin-JN241
25.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
25.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
25.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
25.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
25.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
25.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
25.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
24.14Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
24.14Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
24.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.14Consensusbombesin_onOrthosteric Ligandbb2_on
24.14Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
24.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
24.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
24.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
24.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
23.81Single7EZCUKA7EZC-A2A-UKA
23.81Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
23.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
23.81Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
23.81Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
23.81Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
23.81Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
23.68Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.53Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
23.53Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
23.53Single5UVIZM-2413855UVI-A2A-ZM-241385
23.53Single6MH8ZM-2413856MH8-A2A-ZM-241385
23.53Single6ZINSR486926ZIN-NTS1-SR48692
23.53Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
23.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
23.53Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
23.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
23.53Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.53Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
23.53Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
23.53Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.53Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.53Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
23.53Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
23.53Consensusgrh_offOrthosteric Ligandgnrh1_off
23.53Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
23.08Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
23.08Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.08Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
23.08Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.73Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
22.73Single5WF6UK-4320975WF6-A2A-UK-432097
22.73Single6KNMJN241-96KNM-Apelin-JN241-9
22.73Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
22.73Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
22.73Single7XN9L-054,5227XN9-SST2-L-054,522
22.73Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.73Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
22.73Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
22.73Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
22.73Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
22.22Single3EMLZM-2413853EML-A2A-ZM-241385
22.22Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
22.22Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6D27CAY104716D27-DP2-CAY10471
22.22Single6FJ3PTH6FJ3-PTH1-PTH
22.22Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
22.22Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
22.22Single6S0LZM-2413856S0L-A2A-ZM-241385
22.22Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
22.22Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.22Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
22.22Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.22Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.22Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
22.22Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
22.22Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
22.22Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
22.22Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
22.22Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.22Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
22.22Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
22.22Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
22.22Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
22.22Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
22.22Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
22.22Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
22.22Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
22.22Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
21.74Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.74Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.74Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
21.74Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
21.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
21.74Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Single8WKYPG-9348WKY-MC4-PG-934
21.74Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
21.74Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
21.74Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
21.74Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
21.74Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.74Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
21.74Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
21.43Single3OE8IT1t3OE8-CXCR4-IT1t
21.43Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.43Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.43Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.05Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
21.05Single5IUAQ274563485IUA-A2A-Q27456348-Na
21.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
21.05Single6S0QZM-2413856S0Q-A2A-ZM-241385
21.05Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
21.05Single6Z4SSR486926Z4S-NTS1-SR48692
21.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
21.05Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
21.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
21.05Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
21.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
21.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
21.05Single8JXSPF-61428JXS-D1-PF-6142
21.05Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.05Single8QOTNanobody-E8QOT-μ-Nanobody-E
21.05Single8S4DCMF-0198S4D-Apelin-CMF-019
21.05Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
21.05Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
21.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.83Single3QAKUK-4320973QAK-A2A-UK-432097
20.83Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
20.83Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.83Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.83Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
20.83Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.83Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.69Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
20.69Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.69Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
20.69Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
20.69Consensusbradykinin_onOrthosteric Ligandbk2_on
20.69Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
20.69Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
20.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
20.00Single5TZRMK86665TZR-FFA1-MK8666
20.00Single5WF5UK-4320975WF5-A2A-UK-432097
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.00Single6PT2KGCHM076PT2-δ-KGCHM07
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7PX4PSB-21137PX4-A2A-PSB-2113
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
20.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
20.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
20.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
20.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
20.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
20.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
20.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
19.23Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
19.23Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.05Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
19.05Single4PY02MeSATP4PY0-P2Y12-2MeSATP
19.05Single4RWADIPP-NH24RWA-δ-DIPP-NH2
19.05Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
19.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
19.05Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
19.05Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.05Single7K15MKD0467K15-BLT1-MKD046-Na
19.05Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
19.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
19.05Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
19.05Single8XYIVUF106618XYI-CXCR3-VUF10661
19.05Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
19.05Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
19.05Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.05Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
19.05Consensuslpl_offOrthosteric Ligands1p_off lpa_off
19.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.05Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
18.75Single4O9RCyclopamine4O9R-SMO-Cyclopamine
18.75Single5L7IVismodegib5L7I-SMO-Vismodegib
18.75Single7UL2SR486927UL2-NTS1-SR48692-Na
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
18.75Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
18.75Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
18.75Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
18.75Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
18.75Consensusneurotensin_offOrthosteric Ligandnts1_off
18.75Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
18.52Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
18.52Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
18.52Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
18.52Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.52Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
18.18Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
18.18Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
18.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
18.18Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
18.18Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
18.18Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
18.18Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
18.18Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
18.18Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensuschemerin_onOrthosteric Ligandcml1_on
18.18Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
18.18Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
18.18Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
17.86Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.86Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
17.65Single3PWHZM-2413853PWH-A2A-ZM-241385
17.65Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
17.65Single4QINSAG1.54QIN-SMO-SAG1.5
17.65Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
17.65Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
17.65Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
17.65Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
17.65Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7F8ULintitript7F8U-CCKA-Lintitript
17.65Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.65Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
17.65Single7XRRLemborexant7XRR-OX2-Lemborexant
17.65Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
17.65Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
17.65Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
17.65Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.65Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.39Single4UG2CGS216804UG2-A2A-CGS21680
17.39Single5ZTYAM102575ZTY-CB2-AM10257
17.39Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
17.39Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.39Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
17.39Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
17.39Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
17.39Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.39Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
17.39Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
17.39Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
17.39Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39Consensuskisspeptin_onOrthosteric Ligandkiss1_on
17.39Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
17.39Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
17.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
17.24Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
17.24Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
16.67Single3REYXAC3REY-A2A-XAC
16.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
16.67Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
16.67Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.67Single5JTBZM-2413855JTB-A2A-ZM-241385
16.67Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
16.67Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
16.67Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
16.67Single6IQLL7458706IQL-D4-L745870
16.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
16.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.67Single7AROLUF58337ARO-A2A-LUF5833-Na
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7T32ZM-2413857T32-A2A-ZM-241385
16.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
16.67Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
16.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8KIGSHU91198KIG-MC3-SHU9119-Ca
16.67Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.67Single8WDTphotoNECA8WDT-A2A-photoNECA
16.67Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Consensusa2_offOrthosteric Liganda2a_off
16.67Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.67Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
16.67Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
16.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
16.13Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
16.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.00Single8IEBA1LYA8IEB-GPR156-A1LYA
16.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
15.79Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
15.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.79Single4QIMANTA XV4QIM-SMO-ANTA XV
15.79Single4YAYZD-71554YAY-AT1-ZD-7155
15.79Single5DHGC-355DHG-NOP-C-35
15.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.79Single6GPSMK08126GPS-CCR2-MK0812
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.79Single6TOTLemborexant6TOT-OX1-Lemborexant
15.79Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.79Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.79Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.79Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
15.79Single7PYRPSB-21157PYR-A2A-PSB-2115
15.79Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
15.79Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
15.79Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
15.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.79Single8CU6LJ-45178CU6-A2A-LJ-4517
15.79Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
15.79Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.79Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
15.79Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.79Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.79Consensusa3_onOrthosteric Liganda3a_on
15.79Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.62Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.62Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
15.38Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
15.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.15Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single4JKVTaladegib4JKV-SMO-Taladegib
15.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
15.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
15.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
15.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
15.00Single6GPXMK08126GPX-CCR2-MK0812
15.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
15.00Single7C4SS1P7C4S-S1P3-S1P
15.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
15.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
15.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
15.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
15.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
15.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
15.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
15.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
15.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
15.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.00Consensusblt_offOrthosteric Ligandblt1_off
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
15.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
14.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
14.81Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.81Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.81Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.81Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
14.81Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
14.81Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.81Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.81Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.81Consensusvasop-oxy_onOrthosteric Ligandv2_on
14.81Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.29Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.29Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
14.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.29Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
14.29Single7B6WCyclazosin7B6W-α1b-Cyclazosin
14.29Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
14.29Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
14.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.29Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
14.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
14.29Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
14.29Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
14.29Single7R0CAVP7R0C-V2-AVP-Arrestin2
14.29Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
14.29Single7TUYGSK682753A7TUY-GPR183-GSK682753A
14.29Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
14.29Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
14.29Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.29Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
14.29Single8E0GBU728E0G-μ-BU72
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
14.29Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
14.29Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
14.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.29Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.29Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
14.29Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
14.29Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
14.29Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
14.29Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
14.29Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
14.29Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
14.29Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.29Consensusa2_onOrthosteric Liganda2b_on
14.29Consensusa2_on_gpOrthosteric Liganda2b_on_gp
14.29Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.29Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.29Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
14.29Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
14.29Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
14.29Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
14.29Consensuslpa_onOrthosteric Ligandlpa1_on
14.29Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
14.29Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.29Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
14.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
13.79Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.79Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
13.64Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
13.64Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6A93Risperidone6A93-5-HT2A-Risperidone
13.64Single6MXTSalmeterol6MXT-β2-Salmeterol
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.64Single7DFPSpiperone7DFP-D2-Spiperone
13.64Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.64Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.64Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
13.64Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
13.64Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
13.64Single7YITNalfurafine7YIT-κ-Nalfurafine
13.64Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
13.64Single8JJLOlodaterol8JJL-β2-Olodaterol
13.64Single8JWY2-1188JWY-A2A-2-118
13.64Single8JWZAB9288JWZ-A2A-AB928-Na
13.64Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.64Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.64Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.64Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
13.64Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.64Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.64Consensusalpha1_offOrthosteric Ligandalpha1a_off
13.64Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
13.64Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
13.64Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
13.64Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.64Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
13.64Consensuslpa_offOrthosteric Ligandlpa1_off
13.64Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
13.64Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
13.64Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
13.64Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
13.64Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
13.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
13.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
13.04Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
13.04Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
13.04Single6K1QIRL25006K1Q-ETB-IRL2500
13.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
13.04Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
13.04Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
13.04Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
13.04Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
13.04Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
13.04Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
13.04Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.04Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
13.04Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.04Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
13.04Consensusendothelin_offOrthosteric Ligandetb_off
13.04Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
12.90Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
12.50Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
12.50Single8JPSCCL78JPS-ACKR1-CCL7
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
12.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
12.00Single8IEBA1LYA8IEB-GPR156-A1LYA
12.00Single8IEIA1LYA8IEI-GPR156-A1LYA
12.00Single8IEPA1LYA8IEP-GPR156-A1LYA
12.00Single8IEPA1LYA8IEP-GPR156-A1LYA
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
11.76Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
11.76Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
11.76Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
11.76Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.76Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
11.76Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.76Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.54Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.54Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
11.54Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.54Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
11.43Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.11Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.11Single5WS3EMPA5WS3-OX2-EMPA
11.11Single6B73MP11046B73-κ-MP1104
11.11Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.11Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.11Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.11Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.11Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
11.11Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
11.11Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
11.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8Y0HVUF114188Y0H-CXCR3-VUF11418
11.11Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
11.11Consensusorexin_offOrthosteric Ligandox2_off ox1_off
11.11Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
11.11Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.71Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.71Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.71Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
10.53Single4ZJCSB-6740424ZJC-OX1-SB-674042
10.53Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.53Single6AQFZM-2413856AQF-A2A-ZM-241385
10.53Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.53Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
10.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.53Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.53Single6TPGEMPA6TPG-OX2-EMPA
10.53Single6V9SGTPL114036V9S-OX1-GTPL11403
10.53Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
10.53Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single7VV6C48/807VV6-MRGPRX2-C48/80
10.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.53Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
10.53Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
10.53Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.53Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
10.53Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.53Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
10.53Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
10.53Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
10.53Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
10.34Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
10.34Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
10.00Single5DHHSB-6121115DHH-NOP-SB-612111
10.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
10.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
10.00Single5TGZAM65385TGZ-CB1-AM6538
10.00Single5UENDU1725UEN-A1-DU172
10.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
10.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
10.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
10.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
10.00Single7UL4Alvimopan7UL4-μ-Alvimopan
10.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
10.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
10.00Single8T1WCVN4248T1W-GPR6-CVN424
10.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
10.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
10.00Consensusleukotriene_onOrthosteric Ligandblt_on
10.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.68Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.68Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
9.68Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
9.68Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.68Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
9.68Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.52Single4NTJAZD12834NTJ-P2Y12-AZD1283
9.52Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.52Single5C1MBU725C1M-μ-BU72
9.52Single5WIUNemonapride5WIU-D4-Nemonapride
9.52Single5WIVNemonapride5WIV-D4-Nemonapride-Na
9.52Single5WQCEMPA5WQC-OX2-EMPA
9.52Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
9.52Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.52Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
9.52Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
9.52Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.52Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
9.52Single6TP6Filorexant6TP6-OX1-Filorexant
9.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.52Single7C61Ergotamine7C61-5-HT1B-Ergotamine
9.52Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.52Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
9.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
9.52Single7W41PD1762527W41-BB2-PD176252
9.52Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
9.52Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
9.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.52Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
9.52Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
9.52Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
9.52Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
9.52Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.52Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
9.52Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
9.52Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
9.52Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
9.52Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
9.52Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.52Consensusbombesin_offOrthosteric Ligandbb2_off
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
9.52Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.52Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.52Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.52Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
9.38Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
9.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
9.38Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
9.38Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
9.09Single4DJHJDTic4DJH-κ-JDTic
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
9.09Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
9.09Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.09Single6TQ7SB-3348676TQ7-OX1-SB-334867
9.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
9.09Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
9.09Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.09Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
9.09Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.09Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
9.09Single8XVLZibotentan8XVL-ETA-Zibotentan
9.09Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.09Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
9.09Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
9.09Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
9.09Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
9.09Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.82Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
8.82Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.82Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.70Single4N4WSANT-14N4W-SMO-SANT-1
8.70Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
8.70Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
8.70Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.70Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
8.70Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.70Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
8.70Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
8.70Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.70Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
8.70Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
8.70Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
8.70Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.70Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.57Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
8.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.33Single5X93K-87945X93-ETB-K-8794
8.33Single6IBLArformoterol6IBL-β1-Arformoterol
8.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
8.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
8.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
8.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
8.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.33Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
8.33Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
8.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
8.33Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
8.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.00Single3NY9ICI118-5513NY9-β2-ICI118-551
8.00Single5EE7MK08935EE7-Glucagon-MK0893
8.00Single6PT3DPI-2876PT3-δ-DPI-287
8.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
8.00Single7SK9CCX6627SK9-ACKR3-CCX662
8.00Single8IEIA1LYA8IEI-GPR156-A1LYA
8.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.00Single8X5YAstemizole8X5Y-H1-Astemizole
7.69Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
7.69Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.69Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
7.69Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.50Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.32Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.14Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.14Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
6.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.90Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
6.90Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
6.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
6.67Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.67Single8PWNTheophylline8PWN-A2A-Theophylline
6.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25Single3RFMCaffeine3RFM-A2A-Caffeine
6.25Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
6.25Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.25Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
6.25Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.25Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
6.06Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
6.06Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
6.06Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.06Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
5.88Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.88Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.88Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.88Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.88Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7WC5Psilocin7WC5-5-HT2A-Psilocin
5.88Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.88Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.88Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.88Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.71Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.56Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.56Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.56Single6LI0C176LI0-GPR52-C17
5.56Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.56Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.56Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
5.56Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.56Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.56Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
5.56Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.56Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
5.56Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.56Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.56Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
5.56Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
5.56Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.56Single9B9Y7DY9B9Y-CB1-7DY
5.56Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.56Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.41Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.41Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.26Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.26Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.26Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
5.26Single5U09Taranabant5U09-CB1-Taranabant
5.26Single6AKXA4R6AKX-CCR5-A4R
5.26Single6AKYMaraviroc6AKY-CCR5-Maraviroc
5.26Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
5.26Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.26Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.26Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.26Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Single6TODEMPA6TOD-OX1-EMPA-Na
5.26Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.26Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
5.26Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.26Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.26Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
5.26Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
5.26Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
5.26Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.26Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.26Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.26Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9BA0A1AKN9BA0-CB1-A1AKN
5.26Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.26Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
5.26Consensusangiotensin_offOrthosteric Ligandat1_off
5.26Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.00Single2YDOAdenosine2YDO-A2A-Adenosine
5.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
5.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
5.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
5.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
5.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.00Single6KUXRS-799486KUX-α2a-RS-79948
5.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.00Single6TPKRetosiban6TPK-OT-Retosiban
5.00Single6TPNHTL66416TPN-OX2-HTL6641
5.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
5.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
5.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
5.00Single7UL3Famotidine7UL3-H2-Famotidine
5.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
5.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
5.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
5.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
5.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
5.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
5.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
5.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
5.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
5.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.00Consensussensory_offOrthosteric Ligandopsins_off
5.00Consensusvasop-oxy_offOrthosteric Ligandot_off
4.76Single2Y02Carmoterol2Y02-β1-Carmoterol
4.76Single2Y04Salbutamol2Y04-β1-Salbutamol
4.76Single4EJ4Naltrindole4EJ4-δ-Naltrindole
4.76Single4QKX35V4QKX-β2-35V
4.76Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
4.76Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
4.76Single6IIVDaltroban6IIV-TP-Daltroban
4.76Single6PS1Timolol6PS1-β2-Timolol
4.76Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
4.76Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
4.76Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.76Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
4.76Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
4.76Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
4.76Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
4.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.76Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.76Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
4.76Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.76Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.76Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
4.76Single8JXRLSD8JXR-D1-LSD
4.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.76Single8RLNLUF58348RLN-A2A-LUF5834
4.76Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.76Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
4.76Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.76Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
4.76Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.76Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.76Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76Single9B9ZA1AKO9B9Z-CB1-A1AKO
4.76Single9CHXS-Carazolol9CHX-β2-S-Carazolol
4.76Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
4.76Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.76Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.76Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
4.76Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
4.76Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.55Single2Y00Dobutamine2Y00-β1-Dobutamine
4.55Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.55Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
4.55Single5XPRBosentan5XPR-ETB-Bosentan
4.55Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
4.55Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.55Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
4.55Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
4.55Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.55Single7SINNPS-21437SIN-CaS-NPS-2143
4.55Single7SINNPS-21437SIN-CaS-NPS-2143
4.55Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.55Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
4.55Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
4.55Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.55Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
4.55Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
4.55Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
4.55Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
4.55Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
4.55Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Consensustrace-amine_onOrthosteric Ligandta1_on
4.35Single2YDVNECA2YDV-A2A-NECA
4.35Single3P0GBI1671073P0G-β2-BI167107
4.35Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
4.35Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
4.35Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.35Single4UHRCGS216804UHR-A2A-CGS21680
4.35Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.35Single5G53NECA5G53-A2A-NECA-Gs
4.35Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
4.35Single6E59L-7607356E59-NK1-L-760735
4.35Single6H7JIsoprenaline6H7J-β1-Isoprenaline
4.35Single6J20Aprepitant6J20-NK1-Aprepitant
4.35Single6J21Aprepitant6J21-NK1-Aprepitant
4.35Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
4.35Single6WGTLSD6WGT-5-HT2A-LSD
4.35Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
4.35Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
4.35Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
4.35Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.35Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
4.35Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.35Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.35Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.35Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
4.35Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
4.35Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.35Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.35Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.35Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
4.35Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
4.17Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
4.17Single4AMIBucindolol4AMI-β1-Bucindolol
4.17Single4LDEBI1671074LDE-β2-BI167107
4.17Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
4.17Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.17Single6CM4Risperidone6CM4-D2-Risperidone
4.17Single6IIURamatroban6IIU-TP-Ramatroban
4.17Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
4.17Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
4.17Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.17Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JJ8Formoterol8JJ8-β2-Formoterol
4.17Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
4.17Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
4.17Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.17Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
4.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
4.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
4.00Single6H7LDobutamine6H7L-β1-Dobutamine
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
4.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
4.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
4.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
4.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
4.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
4.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.85Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
3.85Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.57Single6HLOAprepitant6HLO-NK1-Aprepitant
3.45Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
3.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
3.23Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1

Consensus Members
Id Members
7WQ3 7WQ3-GAL1-Galanin-Gi1/β1/γ2
Net Summary
Imin 2.43
Number of Linked Nodes 834
Number of Links 1094
Number of Hubs 206
Number of Links mediated by Hubs 736
Number of Communities 19
Number of Nodes involved in Communities 341
Number of Links involved in Communities 529
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 2031304
Length Of Smallest Path 3
Average Path Length 27.2336
Length of Longest Path 56
Minimum Path Strength 1.35
Average Path Strength 5.30083
Maximum Path Strength 33.01
Minimum Path Correlation 0.7
Average Path Correlation 0.986633
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 45.4462
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.9548
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_peptidegi_cck
gi_apelin
gi_compl-pept
gi_endothelin
gi_formylpeptide
gi_galanin
gi_ghrelin
gi_npy
gi_neurotensin
gi_opioid
gi_orexin
gi_relaxin
gi_somatostatin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_galanin.zip



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