Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1Lig 8.138442220
21x39 4.43143407
31x43 4.695406
41x55 3.361434164
52x39 3.71714407
62x43 5.04357458
72x50 5.96821409
82x53 7.62457527
92x56 3.39929407
10E1x50 8.24048629
11E1x52 6.75667607
123x28 6.39357405
133x29 4.51286426
143x33 7.22786425
153x37 7.47886527
163x43 6.68179458
173x46 4.93786459
183x50 7.31771559
193x53 4.622864178
20I2x57 9.464177
214x57 5.18964427
22E2 14.58141324
23E2x52 6.18643424
245x43 8.15114525
255x47 8.23571409
265x51 5.09107406
275x53 2.64107406
285x58 5.29469758
295x64 3.20964405
305x68 3.70536405
31I3 4.56551704
326x32 2.28893407
336x48 5.81095629
346x49 7.67536406
356x51 4.57643427
366x61 9.43929423
37E3 8.546881123
387x42 6.87643427
397x49 6.34071459
407x53 6.20743559
418x50 6.35629558
42G.HN.30 2.44714407
43G.S1.02 5.293934185
44G.H1.01 3.8965219
45G.S2.06 7.52143403
46G.S2.08 8.594644123
47G.S3.03 7.932295184
48G.S3.04 7.5425417
49G.S3.06 8.42543517
50G.S3.07 3.669644216
51G.s3h2.03 4.76786419
52G.H2.06 5.80469717
53G.H2.07 5.41829519
54G.h2s4.01 6.92314517
55G.S4.02 4.92214418
56G.S4.04 7.31893468
57G.s4h3.04 5.43943598
58G.s4h3.05 6.06107498
59G.H3.09 5.96898769
60G.H3.17 7.9369615
61G.H3.18 7.04821415
62G.S5.03 3.51964406
63G.S5.04 4.9125468
64G.S5.05 3.603435119
65G.S5.07 5.99143409
66G.HG.04 5.298506
67G.hgh4.02 7.685364225
68G.hgh4.05 9.09286405
69G.H4.10 10.10254223
70G.H4.15 5.15143566
71G.h4s6.02 5.06107465
72G.S6.02 6.60143406
73G.S6.04 8.210364115
74G.H5.03 6.044114
75G.H5.08 7.296434129
76G.H5.26 5.118507
77b.lh12x2 4.7675408
78b.h2x5 3.42786445
79b.lhb1x3 3.08314542
80b.lhb1x6 3.6025443
81b.lhb1x11 4.30964404
82b.b1x4 5.12357437
83b.b1x6 8.55536439
84b.l1x3 8.99619639
85b.b2x1 9.10857518
86b.b2x5 6.685637
87b.b3x2 5.72607435
88b.b3x3 3.72408
89b.l3x2 5.50086539
90b.b4x3 4.920714137
91b.b4x4 9.46679438
92b.b4x5 4.060714207
93b.b4x6 10.6076639
94b.b5x2 5.77179407
95b.b5x3 6.48048639
96b.b5x5 5.460714205
97b.b5x7 6.36107407
98b.l5x1 4.191435138
99b.l5x5 8.55061719
100b.b6x5 4.112506
101b.l6x5 6.164144
102b.b7x1 6.423715144
103b.l7x4 3.91143409
104b.b8x3 3.9975406
105b.b8x4 5.862575136
106b.l8x5 2.3125403
107b.b9x3 4.49679406
108b.l9x3 7.36619689
109b.l9x6 5.1275818
110b.b10x5 4.89143609
111b.l10x1 3.75643403
112b.b11x4 5.44607489
113b.l11x2 8.15786489
114b.b12x6 9.62405688
115b.b12x7 6.343574239
116b.b13x7 8.15029577
117b.l13x3 8.08905679
118b.l13x6 4.894519
119b.l13x7 4.34457579
120b.b15x1 7.93464479
121b.b15x2 7.4525416
122b.l15x1 4.6275417
123b.l15x2 5.66429409
124b.b16x4 10.9229476
125b.b16x5 5.31171515
126b.b16x6 7.95408778
127b.b17x5 6.14881617
128b.b17x7 8.59393418
129b.l17x3 9.13262619
130b.l17x6 5.85371519
131b.l17x7 5.13071417
132b.b18x3 5.03964418
133b.b18x5 5.91286405
134b.l18x1 5.83696846
135b.l18x2 5.86107447
136b.b19x2 6.84167616
137b.b19x4 6.06929418
138b.l19x1 6.43964419
139b.l19x2 6.13429519
140b.b20x4 11.1817518
141b.b20x6 6.96976616
142b.b21x1 7.31314517
143b.b21x2 3.87286406
144b.b21x7 6.10976605
145b.b22x5 5.62771547
146b.l22x5 6.9719649
147b.b23x6 6.31959717
148b.l23x1 7.645416
149b.b24x4 7.56393416
150b.b24x6 6.26821418
151b.l24x3 5.25429545
152b.b25x3 7.91679415
153b.l25x3 8.557435109
154b.l25x6 10.775418
155b.l27x1 10.7588717
156b.l27x2 8.336074101
157b.b28x4 8.291074106
158b.b28x6 9.048865109
159b.b28x7 6.41679439
160g.h1x5 1.25536406
161g.h1x11 2.75607409
162g.l1x4 5.4075408
163g.h2x11 10.0239446
164g.ctx3 6.98686509
165g.ctx6 4.08524646
166g.ctx14 6.41321439
167g.ctx15 7.18643439
168g.ctx16 4.99413938
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x43 7x53 69.69519.49714YesYes589
23x43 6x44 52.6496.28YesNo089
36x44 6x48 46.84278.30429NoYes099
46x48 Lig 39.89654.09714YesYes290
52x50 7x49 11.74855.19571YesYes099
67x54 8x50 94.97418.24286NoYes578
72x43 7x54 95.20977.03143YesNo587
82x43 3x46 36.15233.45714YesYes589
93x46 7x53 35.87075.35286YesYes599
102x43 3x50 57.51915.58286YesYes589
113x50 7x53 35.85827.34857YesYes599
121x61 8x53 97.61657.62NoNo055
131x61 8x50 97.4914.44286NoYes058
145x58 6x37 20.57987.03429YesNo088
156x37 G.H5.25 20.08684.94286NoNo088
16G.H5.20 G.H5.25 19.92235.53714NoNo078
17G.H5.20 G.H5.26 19.75768.17714NoYes077
18G.H5.26 I3 16.27734.79571YesYes074
195x68 I3 13.76434.68429YesYes054
205x68 G.H5.13 11.73784.53143YesNo056
21G.H5.13 G.S6.02 11.56836.57143NoYes066
22G.H5.10 G.S6.02 10.71916.09857NoYes046
23G.H5.10 G.S5.03 10.5493.71286NoYes046
248x53 b.l25x4 98.79289.52714NoNo055
25b.l25x4 b.l27x2 98.91915.70143NoYes051
26b.l25x3 b.l27x2 99.1988.10143YesYes1091
27b.b27x3 b.l25x3 49.96057.43429NoYes089
28b.b27x3 b.b28x6 49.81189.35714NoYes089
29b.b25x7 b.b28x6 99.974117.8957NoYes079
30b.b25x7 b.lhb1x11 1005.04857NoYes074
31b.b28x7 b.lhb1x11 19.80873.20286YesYes094
32b.b28x7 g.ctx16 18.59974.14143YesYes398
33b.l4x2 g.ctx16 15.71166.48429NoYes348
34b.l2x5 b.l4x2 23.161923.3729NoNo054
35b.b28x4 b.l25x3 49.76819.35714YesYes1069
36b.b28x4 b.b28x6 50.06087.29143YesYes1069
37b.l2x3 b.l2x5 22.06643.57143NoNo085
38b.b3x1 b.l2x3 21.97594.84714NoNo058
39b.b3x1 b.b6x5 21.88523.18NoYes056
40b.lhb1x11 g.ctx5 81.05415.65429YesNo049
41b.l22x1 g.ctx5 81.03754.71714NoNo099
42b.b23x1 b.l22x1 40.48014.50286NoNo059
43b.b23x1 g.ctx6 40.62013.75714NoYes056
44b.l22x5 g.ctx6 89.40126.07286YesYes496
45b.l22x5 g.h2x12 86.66623.18286YesNo497
46b.l18x1 g.h2x12 86.78212.99286YesNo467
47b.b22x5 b.l18x1 84.71648.72429YesYes476
48b.b22x5 b.b23x2 84.30949.91714YesNo076
49b.b21x7 b.b23x2 84.18795.02571YesNo056
50b.b21x7 b.b24x6 82.27097.99143YesYes058
51b.b23x6 b.b24x6 81.32647.71714YesYes178
52b.b23x6 b.l21x7 80.67324.22286YesNo175
53b.l21x7 b.l23x1 80.62855.33429NoYes156
54b.l23x1 b.l25x6 80.227117.6971YesYes168
55b.l25x6 b.l27x1 61.826417.2786YesYes187
56b.b2x1 b.l27x1 61.04378.81857YesYes187
57b.b2x1 b.l3x1 60.885215.1371YesNo189
58b.l3x1 b.l5x5 60.79327.04143NoYes199
59b.l22x1 g.ctx3 40.6798.62286NoYes099
60g.ctx3 g.ctx6 50.40029.11143YesYes096
61G.H3.17 b.l25x6 18.30144.42857YesYes158
62G.H3.15 G.H3.17 17.65896.45714NoYes185
63G.H3.15 G.H3.18 17.37865.86714NoYes185
64G.H3.18 G.S4.02 17.1248.97143YesYes158
65G.h2s4.01 b.l5x5 57.566812.8857YesYes179
66G.S4.02 G.S5.02 16.34553.57429YesNo088
67G.H3.09 G.S5.02 15.16783.76571YesNo098
68G.H2.07 G.h2s4.01 57.70223.15YesYes197
69G.H2.07 b.l9x6 57.91653.44571YesYes198
70G.H2.06 b.l9x6 56.52415.29YesYes178
71G.H2.06 b.l17x6 27.95778.29714YesYes179
72G.H2.06 b.l19x1 27.95793.95YesYes179
73b.b2x4 b.b6x5 15.41113.42571NoYes066
74b.b10x4 b.b2x4 15.313413.8643NoNo066
75b.l17x5 b.l17x6 27.86754.41714NoYes169
76b.l17x5 b.l19x2 55.37023.15429NoYes169
77b.l17x3 b.l19x2 39.68484.68YesYes199
78b.b19x4 b.l17x3 24.95798.21286YesYes189
79b.b19x4 b.b20x6 12.50297.59571YesYes186
80b.b17x7 b.b20x6 32.672812.2471YesYes186
81b.b17x7 b.b21x1 17.35765.12YesYes187
82b.1x18 b.b21x1 11.61094.25429NoYes047
83b.l17x5 b.l19x1 27.81543.99571NoYes169
84b.b20x4 b.l17x3 13.460217.8943YesYes189
85b.b20x4 b.b20x6 24.99325.19143YesYes186
86b.b20x2 b.l19x2 14.09676.81429NoYes069
87b.b20x2 b.b20x4 13.45927.76143NoYes068
88b.1x18 b.b21x2 10.64386.17429NoYes046
89b.b18x3 b.b19x4 12.15043.69143YesYes188
90b.b15x2 b.b18x3 10.54316.36143YesYes168
91b.b16x7 b.b17x4 15.31038.50857NoNo095
92b.b17x5 b.b17x7 14.36217.36429YesYes178
93b.b17x4 b.b17x5 12.44683.83714NoYes157
94b.b16x7 b.l16x3 17.52897.23857NoNo093
95g.ctx3 g.ctx4 10.19984.14YesNo097
96b.b17x2 b.l16x3 15.91712.70571NoNo033
97b.b17x2 g.h1x13 14.30522.06286NoNo031
98g.h1x13 g.h1x9 12.69321.16NoNo016
99g.h1x5 g.h1x9 11.08121.82857YesNo066
1003x43 7x49 12.63817.48571YesYes589
1013x50 5x58 21.39278.81857YesYes598
102b.l26x5 g.ctx4 10.1195.75NoNo007
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x37Lig16.59712YesYes7010
3x40Lig3.308572NoYes7010
5x43Lig20.54292YesYes5010
6x48Lig4.097142YesYes9010
3x33Lig14.75572YesYes5010
5x39Lig12.44712NoYes5010
2x60Lig3.614292NoYes6010
3x29Lig6.128572YesYes6010
6x51Lig4.934292YesYes7010
7x34Lig8.517140NoYes5010
E2x52Lig4.448572YesYes4010
5x36Lig3.512NoYes4010
E3Lig7.384292YesYes3010
E2Lig6.651432YesYes4010
E2x51Lig3.278570NoYes3010
5x28Lig3.337142NoYes5010
E1Lig7.082862NoYes4010
7x35Lig3.221432NoYes4010
2x533x324.868572YesNo7622
2x533x368.352862YesNo7821
2x537x4213.62432YesYes7722
2x603x323.302862NoNo6612
2x647x357.594290NoNo6421
E1x49E219.07712NoYes4421
3x25E1x5011.38142NoYes9922
3x29E1x503.478572YesYes6912
E1x50E2x508.207142YesNo9922
3x22E27.627142NoYes4421
3x253x293.114292NoYes9621
3x25E2x506.52NoNo9922
3x294x655.332YesNo6512
3x333x373.582862YesYes5711
3x334x576.401432YesYes5712
3x334x614.171432YesNo5412
3x367x424.525712NoYes8712
3x373x416.432YesNo7612
3x374x569.394292YesNo7512
3x405x503.784292NoNo7912
3x406x484.377142NoYes7911
4x574x613.172862YesNo7422
4x614x654.305712NoNo4522
4x64E219.27292NoYes5421
4x645x355.864292NoNo5122
4x65E2x526.691430NoYes5421
E2E250.18432YesYes4411
E2E2x504.828572YesNo4912
E2E2x525.052862YesYes4411
5x39E2x528.552862NoYes5411
5x28E26.477142NoYes5411
5x31E24.875710NoYes4421
5x32E24.754290NoYes3421
5x35E26.042862NoYes1421
5x27E24.532NoYes3421
5x255x285.765710NoNo5521
5x29E36.544290NoYes1321
5x33E39.251430NoYes1321
5x36E35.165712NoYes4311
5x395x436.552NoYes5511
5x405x433.428570NoYes4521
5x436x526.677142YesNo5812
5x436x553.557142YesNo5512
6x446x488.304290NoYes9921
6x486x523.442862YesNo9812
6x487x415.927142YesNo9812
6x487x458.717142YesNo9912
6x517x376.072862YesNo7712
6x517x383.362YesNo7612
6x517x413.938572YesNo7812
6x61E33.292YesYes3321
6x617x2724.16862YesNo3322
E3E322.67572YesYes3311
7x27E311.252NoYes3321
7x30E33.115710NoYes4321
7x387x424.527140NoYes6722
3x36Lig5.492862NoYes8010
7x31Lig2.901432NoYes4010
1x357x352.095710NoNo5421
6x58E31.974290NoYes4321
2x67E11.472860NoNo3421
3x374x531.392YesNo7812
7x287x311.382860NoNo1421
5x30E30.6885712NoYes5321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
95.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
90.48Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
80.95Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
72.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
71.43Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
71.43Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
62.50Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
60.87Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
60.87Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
57.14Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
56.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
52.17Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
52.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
52.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
50.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
50.00Consensusangiotensin_onOrthosteric Ligandat1_on
50.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.28Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
48.15Single6JODAngiotensin II6JOD-AT2-Angiotensin II
48.15Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.15Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.15Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
48.15Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.15Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
48.15Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
47.83Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
47.62Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
46.67Single6IGLIRL16206IGL-ETB-IRL1620
46.43Single8ZRTET-18ZRT-ETB-ET-1
46.15Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
46.15Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
46.15Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
45.83Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
45.45Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
45.45Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
45.45Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
45.16Single5GLHEndothelin-15GLH-ETB-Endothelin-1
45.16Single6IGKEndothelin-36IGK-ETB-Endothelin-3
44.83Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
44.83Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
44.44Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
44.44Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
44.44Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.44Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
44.44Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
44.44Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
44.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
43.48Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
43.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
43.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
43.33Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
43.33Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
42.86Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
42.42Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
42.31Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
42.31Single8WDTphotoNECA8WDT-A2A-photoNECA
42.31Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.31Consensuslpl_onOrthosteric Ligands1p_on lpa_on
42.31Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
42.31Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
41.94Single8IY6Endothelin-18IY6-ETB-Endothelin-1
41.94Consensusendothelin_onOrthosteric Ligandetb_on eta_on
41.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
41.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
41.38Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
41.38Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
41.38Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
41.38Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.74Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
40.74Single7XNACYN1548067XNA-SST2-CYN154806
40.74Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
40.74Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
40.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
40.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
40.00Single7EZCUKA7EZC-A2A-UKA
40.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
40.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
40.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
40.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
40.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
40.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
39.39Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
39.39Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
39.29Single5WF5UK-4320975WF5-A2A-UK-432097
39.29Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
39.29Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
39.13Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
39.13Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
39.13Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.71Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
38.71Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
38.46Single5WF6UK-4320975WF6-A2A-UK-432097
38.46Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
38.46Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
38.46Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
38.46Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
38.46Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
38.46Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
38.46Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.46Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.24Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
38.10Single6ME9Ramelteon6ME9-MT2-Ramelteon
38.10Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
37.93Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
37.93Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
37.93Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.93Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
37.93Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
37.93Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
37.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
37.50Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
37.50Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
37.50Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
37.50Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.50Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.50Consensusbradykinin_onOrthosteric Ligandbk2_on
37.50Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
37.50Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
37.50Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
37.50Consensusrelaxin_onOrthosteric Ligandrxfp4_on
37.50Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
37.50Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
37.50Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
37.04Single4IARErgotamine4IAR-5-HT1B-Ergotamine
37.04Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
37.04Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
37.04Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
37.04Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
37.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
37.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
37.04Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
37.04Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
37.04Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
37.04Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.04Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.04Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
37.04Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
37.04Consensussomatostatin_offOrthosteric Ligandsst2_off
37.04Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
36.67Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
36.67Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
36.67Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
36.67Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
36.36Single7T32ZM-2413857T32-A2A-ZM-241385
36.36Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
36.36Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
36.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.00Single6A93Risperidone6A93-5-HT2A-Risperidone
36.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
36.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
36.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
36.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
36.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
36.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
36.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
36.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
36.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
36.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
36.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
36.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
36.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
36.00Consensuslpa_offOrthosteric Ligandlpa1_off
36.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
36.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
36.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
35.71Single3QAKUK-4320973QAK-A2A-UK-432097
35.71Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
35.71Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
35.71Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.71Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
35.71Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
35.71Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
35.71Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
35.48Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
35.29Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
35.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
34.78Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
34.78Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
34.78Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
34.78Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
34.78Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
34.62Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
34.62Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
34.62Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
34.62Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
34.62Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
34.62Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
34.62Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
34.62Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
34.62Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
34.62Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
34.62Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
34.62Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
34.62Consensuschemerin_onOrthosteric Ligandcml1_on
34.62Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
34.48Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
34.48Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
34.48Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.48Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.48Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
34.48Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
34.48Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.48Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
34.48Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
34.38Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.38Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Single4UG2CGS216804UG2-A2A-CGS21680
33.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
33.33Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
33.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
33.33Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
33.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
33.33Single6S0QZM-2413856S0Q-A2A-ZM-241385
33.33Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
33.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
33.33Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
33.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
33.33Single7SK9CCX6627SK9-ACKR3-CCX662
33.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
33.33Single7XN9L-054,5227XN9-SST2-L-054,522
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
33.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JXSPF-61428JXS-D1-PF-6142
33.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
33.33Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
33.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
33.33Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
33.33Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
33.33Consensusdp_offOrthosteric Liganddp2_off
33.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
33.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
33.33Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
33.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
33.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
32.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusbombesin_onOrthosteric Ligandbb2_on
32.35Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.35Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.35Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
32.35Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
32.26Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
32.26Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.26Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
32.26Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
32.26Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
32.26Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.14Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
32.14Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
32.14Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
32.14Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
32.14Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
32.14Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
32.14Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
32.14Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
32.14Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
32.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
32.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
32.00Single6J21Aprepitant6J21-NK1-Aprepitant
32.00Single6OS1TRV0266OS1-AT1-TRV026
32.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
32.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
32.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
32.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
32.00Single7PX4PSB-21137PX4-A2A-PSB-2113
32.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
32.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
32.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
32.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
32.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
32.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
32.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
32.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
32.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
32.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
32.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
32.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
32.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
32.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
32.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
31.82Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
31.82Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
31.82Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
31.82Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
31.25Single4XT3Fractalkine4XT3-US28-Fractalkine
31.25Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
31.25Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.03Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.03Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
31.03Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.03Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
31.03Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
31.03Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
31.03Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
31.03Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.03Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
31.03Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.77Single3D4STimolol3D4S-β2-Timolol
30.77Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
30.77Single6MXTSalmeterol6MXT-β2-Salmeterol
30.77Single6OS2TRV0266OS2-AT1-TRV026
30.77Single7DFPSpiperone7DFP-D2-Spiperone
30.77Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.77Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
30.77Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
30.77Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
30.77Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
30.77Single7YITNalfurafine7YIT-κ-Nalfurafine
30.77Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
30.77Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.77Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
30.77Single8JJLOlodaterol8JJL-β2-Olodaterol
30.77Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
30.77Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
30.77Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
30.77Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
30.77Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
30.77Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
30.77Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
30.77Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
30.77Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.77Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.77Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.77Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.77Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.77Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.77Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
30.77Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
30.77Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
30.77Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
30.77Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.77Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
30.77Consensusorexin_onOrthosteric Ligandox2_on
30.77Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.77Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.43Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
30.43Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
30.43Single5UVIZM-2413855UVI-A2A-ZM-241385
30.43Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
30.43Single6MH8ZM-2413856MH8-A2A-ZM-241385
30.43Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
30.43Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
30.43Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
30.43Single7UL3Famotidine7UL3-H2-Famotidine
30.43Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
30.43Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
30.43Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
30.43Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
30.43Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
30.30Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.30Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
30.30Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
30.30Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.30Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.00Single3OE0CVX153OE0-CXCR4-CVX15
30.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
30.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
30.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.63Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.63Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.63Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
29.63Single6IBLArformoterol6IBL-β1-Arformoterol
29.63Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.63Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
29.63Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
29.63Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
29.63Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
29.63Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
29.63Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
29.63Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.63Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
29.63Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
29.63Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
29.63Consensusprostanoid_offOrthosteric Ligandep_off dp_off
29.17Single3EMLZM-2413853EML-A2A-ZM-241385
29.17Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
29.17Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.17Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
29.17Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
29.17Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
29.17Single6DRXLisuride6DRX-5-HT2B-Lisuride
29.17Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
29.17Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
29.17Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
29.17Single6S0LZM-2413856S0L-A2A-ZM-241385
29.17Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
29.17Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.17Single7PYRPSB-21157PYR-A2A-PSB-2115
29.17Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
29.17Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.17Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.17Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
29.17Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
29.17Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.17Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
29.17Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
29.17Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
29.17Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.17Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
29.17Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.17Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
29.17Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
29.17Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
29.17Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
29.17Single9CHXS-Carazolol9CHX-β2-S-Carazolol
29.17Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
29.17Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensusblt_onOrthosteric Ligandblt1_on
29.17Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
29.17Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.17Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.17Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.17Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
29.17Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
29.17Consensushca_on_gpOrthosteric Ligandhca2_on_gp
29.17Consensusleukotriene_onOrthosteric Ligandblt_on
29.17Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.03Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
29.03Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
29.03Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
29.03Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single3NY9ICI118-5513NY9-β2-ICI118-551
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
28.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
28.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.57Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
28.57Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
28.57Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
28.57Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
28.57Single8X5YAstemizole8X5Y-H1-Astemizole
28.57Single8XQJJN2418XQJ-Apelin-JN241
28.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.57Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
28.57Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
28.57Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.12Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.12Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.12Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.12Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
28.12Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
28.12Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
28.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
28.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
28.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
28.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
28.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
28.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
28.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
28.00Single7W41PD1762527W41-BB2-PD176252
28.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
28.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
28.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
28.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
28.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
28.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
28.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
28.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
28.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
28.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
28.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
28.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
28.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
28.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
28.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
28.00Consensusbombesin_offOrthosteric Ligandbb2_off
28.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
28.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
28.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
28.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
28.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
28.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Consensustrace-amine_onOrthosteric Ligandta1_on
27.59Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
27.59Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
27.59Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
27.59Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.59Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
27.59Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
27.59Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
27.59Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
27.59Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
27.59Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
27.59Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
27.27Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.27Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.27Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
27.27Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.27Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
27.27Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.27Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
27.27Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
27.27Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
27.27Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
27.27Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
27.27Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
26.92Single2YDVNECA2YDV-A2A-NECA
26.92Single3P0GBI1671073P0G-β2-BI167107
26.92Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.92Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.92Single4UHRCGS216804UHR-A2A-CGS21680
26.92Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.92Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.92Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.92Single5G53NECA5G53-A2A-NECA-Gs
26.92Single5TZRMK86665TZR-FFA1-MK8666
26.92Single5XR8AM8415XR8-CB1-AM841
26.92Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.92Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
26.92Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.92Single6J20Aprepitant6J20-NK1-Aprepitant
26.92Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.92Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
26.92Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
26.92Single7F1TMIP-1a7F1T-CCR5-MIP-1a
26.92Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.92Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.92Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
26.92Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.92Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
26.92Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
26.92Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.92Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.92Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
26.92Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
26.92Single8E0GBU728E0G-μ-BU72
26.92Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
26.92Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
26.92Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.92Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.92Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
26.92Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
26.92Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
26.92Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
26.92Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.92Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.92Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
26.92Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.92Consensusa2_onOrthosteric Liganda2b_on
26.92Consensusa2_on_gpOrthosteric Liganda2b_on_gp
26.92Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.92Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.92Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
26.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.92Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
26.92Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.92Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.92Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
26.92Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.92Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
26.92Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
26.92Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
26.92Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
26.92Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.92Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.92Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.92Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.92Consensuslpa_onOrthosteric Ligandlpa1_on
26.92Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
26.67Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.67Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
26.67Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
26.67Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.67Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.67Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.67Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.67Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
26.47Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
26.47Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
26.32Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.09Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
26.09Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.09Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
26.09Single6AKYMaraviroc6AKY-CCR5-Maraviroc
26.09Single6B73MP11046B73-κ-MP1104
26.09Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.09Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.09Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
26.09Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
26.09Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
26.09Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
26.09Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
26.09Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GNGIstradefylline8GNG-A2A-Istradefylline
26.09Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
26.09Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.09Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
26.09Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.09Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
26.09Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
26.09Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
26.09Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
26.09Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
26.09Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.09Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
26.09Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
26.09Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
25.93Single4AMIBucindolol4AMI-β1-Bucindolol
25.93Single4LDEBI1671074LDE-β2-BI167107
25.93Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.93Single4PY02MeSATP4PY0-P2Y12-2MeSATP
25.93Single4RWADIPP-NH24RWA-δ-DIPP-NH2
25.93Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.93Single4XESNeurotensin4XES-NTS1-Neurotensin
25.93Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.93Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
25.93Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.93Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.93Single6KQICP559406KQI-CB1-CP55940-Org27569
25.93Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
25.93Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
25.93Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.93Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.93Single6ZG4HTL00099366ZG4-M1-HTL0009936
25.93Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
25.93Single7K15MKD0467K15-BLT1-MKD046-Na
25.93Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
25.93Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.93Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.93Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.93Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.93Single8JJ8Formoterol8JJ8-β2-Formoterol
25.93Single8JWY2-1188JWY-A2A-2-118
25.93Single8JWZAB9288JWZ-A2A-AB928-Na
25.93Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
25.93Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.93Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.93Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.93Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.93Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.93Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.93Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.93Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.93Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.93Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.93Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.93Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.93Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
25.93Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
25.93Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.93Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.81Single6PT2KGCHM076PT2-δ-KGCHM07
25.81Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.81Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.81Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.71Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.71Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.71Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5JTBZM-2413855JTB-A2A-ZM-241385
25.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
25.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single5X93K-87945X93-ETB-K-8794
25.00Single6A94Zotepine6A94-5-HT2A-Zotepine
25.00Single6AQFZM-2413856AQF-A2A-ZM-241385
25.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
25.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
25.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
25.00Single6TPNHTL66416TPN-OX2-HTL6641
25.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
25.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
25.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
25.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
25.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
25.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
25.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
25.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
25.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
25.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
25.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
25.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
25.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
25.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
25.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
25.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single8XWFCXCL38XWF-CXCR2-CXCL3
25.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
25.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
25.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusendothelin_offOrthosteric Ligandetb_off
25.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensushca_onOrthosteric Ligandhca2_on
25.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
24.39Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
24.32Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
24.32Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
24.32Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
24.32Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
24.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
24.24Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
24.24Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
24.24Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
24.24Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
24.24Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
24.24Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.24Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
24.24Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
24.14Single6KNMJN241-96KNM-Apelin-JN241-9
24.14Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
24.14Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
24.14Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.14Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
24.14Single8QJ2pN1628QJ2-MC4-pN162-Gs
24.14Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
24.14Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
24.14Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single2Y04Salbutamol2Y04-β1-Salbutamol
24.00Single3NY8ICI118-5513NY8-β2-ICI118-551
24.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
24.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
24.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
24.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
24.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
24.00Single6D27CAY104716D27-DP2-CAY10471
24.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
24.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
24.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
24.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
24.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
24.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
24.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
24.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
24.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
24.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
24.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
24.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
24.00Single7UL4Alvimopan7UL4-μ-Alvimopan
24.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
24.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
24.00Single7V3ZCP559407V3Z-CB1-CP55940
24.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
24.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
24.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
24.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
24.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
24.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
24.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
24.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
24.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
24.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
24.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
24.00Single8JXRLSD8JXR-D1-LSD
24.00Single8K5DGSK2560738K5D-HCA2-GSK256073
24.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
24.00Single8T1WCVN4248T1W-GPR6-CVN424
24.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
24.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
24.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.00Single8X64Desloratadine8X64-H1-Desloratadine
24.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
24.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
24.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
24.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.00Consensusa3_onOrthosteric Liganda3a_on
24.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
24.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
24.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
24.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
24.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
24.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
23.53Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
23.53Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
23.53Single7SK3CXCL127SK3-ACKR3-CXCL12
23.53Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.53Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
23.53Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
23.33Single4XT1Fractalkine4XT1-US28-Fractalkine
23.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
23.33Single7QA8Peptide7QA8-STE2-Peptide
23.33Single7QA8Peptide7QA8-STE2-Peptide
23.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
23.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
23.33Single8IEBA1LYA8IEB-GPR156-A1LYA
23.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
23.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
23.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.33Single8XWNCXCL88XWN-CXCR2-CXCL8
23.08Single2RH1S-Carazolol2RH1-β2-S-Carazolol
23.08Single2Y03Isoprenaline2Y03-β1-Isoprenaline
23.08Single4NTJAZD12834NTJ-P2Y12-AZD1283
23.08Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
23.08Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
23.08Single5C1MBU725C1M-μ-BU72
23.08Single5N2SPSB365N2S-A1-PSB36
23.08Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.08Single5TVNLSD5TVN-5-HT2B-LSD
23.08Single5WIUNemonapride5WIU-D4-Nemonapride
23.08Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.08Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
23.08Single5XPRBosentan5XPR-ETB-Bosentan
23.08Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.08Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
23.08Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.08Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.08Single6PS6Timolol6PS6-β2-Timolol
23.08Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.08Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
23.08Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.08Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
23.08Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
23.08Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
23.08Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.08Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
23.08Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
23.08Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.08Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
23.08Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
23.08Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
23.08Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
23.08Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.08Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.08Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
23.08Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
23.08Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
23.08Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.08Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.08Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
23.08Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
23.08Consensusamine_offonOrthosteric Ligandamine_off amine_on
23.08Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
23.08Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
23.08Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
23.08Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
23.08Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.08Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
23.08Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
23.08Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.08Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
23.08Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.86Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
22.86Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.73Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
22.73Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
22.73Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
22.73Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
22.73Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
22.73Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.73Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
22.73Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.73Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
22.73Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
22.73Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
22.58Single6HLOAprepitant6HLO-NK1-Aprepitant
22.58Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.58Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.22Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.22Single4DJHJDTic4DJH-κ-JDTic
22.22Single4U15Tiotropium4U15-M3-Tiotropium
22.22Single6E59L-7607356E59-NK1-L-760735
22.22Single6H7JIsoprenaline6H7J-β1-Isoprenaline
22.22Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
22.22Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
22.22Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Single6OL9Tiotropium6OL9-M5-Tiotropium
22.22Single6TQ7SB-3348676TQ7-OX1-SB-334867
22.22Single6WGTLSD6WGT-5-HT2A-LSD
22.22Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.22Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
22.22Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
22.22Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
22.22Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.22Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
22.22Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.22Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
22.22Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
22.22Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.22Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.22Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.22Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.22Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
22.22Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.22Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
22.22Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.22Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
22.22Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.22Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
22.22Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
22.22Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
22.22Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.22Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.22Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
22.22Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
22.22Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.22Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
22.22Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.22Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusneurotensin_onOrthosteric Ligandnts1_on
22.22Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.22Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
22.22Consensustachykinin_offOrthosteric Ligandnk1_off
21.88Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
21.88Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
21.88Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.88Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
21.88Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.88Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.88Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
21.74Single3OE9IT1t3OE9-CXCR4-IT1t
21.74Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.74Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
21.74Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
21.74Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
21.74Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
21.74Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.74Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
21.74Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
21.74Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.74Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
21.74Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.74Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
21.74Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
21.74Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
21.74Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
21.74Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.74Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
21.74Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
21.74Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.74Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
21.74Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.74Consensusgq_nucleotideOrthosteric Ligandgq_p2y
21.74Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.43Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.43Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.43Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
21.43Single4N4WSANT-14N4W-SMO-SANT-1
21.43Single5CXVTiotropium5CXV-M1-Tiotropium
21.43Single6CM4Risperidone6CM4-D2-Risperidone
21.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.43Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.43Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.43Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.43Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.43Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.43Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
21.43Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.43Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.43Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
21.43Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
21.43Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.43Single8XQJJN2418XQJ-Apelin-JN241
21.43Single8XWACXCL18XWA-CXCR2-CXCL1
21.43Single8XWMCXCL68XWM-CXCR2-CXCL6
21.43Single8XWSCXCL58XWS-CXCR2-CXCL5
21.43Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
21.43Single8XYIVUF106618XYI-CXCR3-VUF10661
21.43Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.43Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
21.43Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.43Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.43Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.43Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
21.21Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.21Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
21.21Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.21Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.21Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.21Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
21.05Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
21.05Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.83Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
20.83Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.83Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.83Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.83Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
20.83Single3PWHZM-2413853PWH-A2A-ZM-241385
20.83Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.83Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.83Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.83Single6AKXA4R6AKX-CCR5-A4R
20.83Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.83Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
20.83Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.83Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
20.83Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.83Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
20.83Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.83Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.83Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
20.83Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.83Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
20.83Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
20.83Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.83Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.83Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
20.83Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
20.83Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
20.83Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
20.83Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
20.83Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.83Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.83Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
20.83Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.83Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.83Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.83Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
20.83Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.83Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.83Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.83Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.83Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.83Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.83Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.83Consensusorexin_offOrthosteric Ligandox2_off ox1_off
20.83Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
20.83Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.69Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.69Single6H7LDobutamine6H7L-β1-Dobutamine
20.69Single6K1QIRL25006K1Q-ETB-IRL2500
20.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
20.69Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.69Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
20.69Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.69Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.69Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
20.69Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
20.69Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
20.69Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
20.69Single8XVUCXCL28XVU-CXCR2-CXCL2
20.69Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.69Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.69Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.69Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.69Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.69Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.69Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.69Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.59Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.59Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.51Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.51Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.00Single2YDOAdenosine2YDO-A2A-Adenosine
20.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.00Single3REYXAC3REY-A2A-XAC
20.00Single3RZECidoxepin3RZE-H1-Cidoxepin
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.00Single6FJ3PTH6FJ3-PTH1-PTH
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.00Single6PS4ICI118-5516PS4-β2-ICI118-551
20.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
20.00Single6PT3DPI-2876PT3-δ-DPI-287
20.00Single6TPGEMPA6TPG-OX2-EMPA
20.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
20.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
20.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
20.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
20.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
20.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
20.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
20.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
20.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
20.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
20.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.00Consensussensory_offOrthosteric Ligandopsins_off
19.44Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.44Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
19.44Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
19.44Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.44Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
19.35Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.35Single7F8XNN90567F8X-CCKA-NN9056
19.35Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.35Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8IEIA1LYA8IEI-GPR156-A1LYA
19.35Single8IEPA1LYA8IEP-GPR156-A1LYA
19.35Single8IEPA1LYA8IEP-GPR156-A1LYA
19.35Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.35Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.35Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
19.35Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.35Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
19.23Single2Y01Dobutamine2Y01-β1-Dobutamine
19.23Single2Y02Carmoterol2Y02-β1-Carmoterol
19.23Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.23Single4EJ4Naltrindole4EJ4-δ-Naltrindole
19.23Single4MQSIperoxo4MQS-M2-Iperoxo
19.23Single4QKX35V4QKX-β2-35V
19.23Single4U14Tiotropium4U14-M3-Tiotropium
19.23Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
19.23Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.23Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.23Single5UENDU1725UEN-A1-DU172
19.23Single5UIGCmpd-15UIG-A2A-Cmpd-1
19.23Single6H7MSalbutamol6H7M-β1-Salbutamol
19.23Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.23Single6PS1Timolol6PS1-β2-Timolol
19.23Single6TOTLemborexant6TOT-OX1-Lemborexant
19.23Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.23Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.23Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
19.23Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
19.23Single7BU7BI1671077BU7-β1-BI167107
19.23Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
19.23Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
19.23Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
19.23Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
19.23Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
19.23Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
19.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
19.23Single8CU6LJ-45178CU6-A2A-LJ-4517
19.23Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.23Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
19.23Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
19.23Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
19.23Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
19.23Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
19.23Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
19.23Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
19.23Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
19.23Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
19.23Single8JJOAlprenolol8JJO-β2-Alprenolol
19.23Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
19.23Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
19.23Single8RLNLUF58348RLN-A2A-LUF5834
19.23Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.23Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
19.23Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
19.23Single8X63Mepyramine8X63-H1-Mepyramine
19.23Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
19.23Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
19.23Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
19.23Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
19.23Consensusalpha2_onOrthosteric Ligandalpha2b_on
19.23Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
19.23Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.23Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
19.23Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
19.23Consensuscck_offOrthosteric Ligandccka_off
19.23Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.23Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
19.23Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
19.23Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
19.23Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
19.23Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
19.23Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
19.23Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
19.23Consensushistamine_offOrthosteric Ligandh1_off
19.23Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
19.23Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
19.23Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
19.05Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
19.05Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
19.05Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
19.05Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.92Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
18.92Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.92Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
18.92Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.75Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.75Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.75Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.75Single7SK5CXCL127SK5-ACKR3-CXCL12
18.75Single8IEBA1LYA8IEB-GPR156-A1LYA
18.75Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.75Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.75Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.75Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single2Y00Dobutamine2Y00-β1-Dobutamine
18.52Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
18.52Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.52Single5WQCEMPA5WQC-OX2-EMPA
18.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.52Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
18.52Single6LUQHaloperidol6LUQ-D2-Haloperidol
18.52Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
18.52Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
18.52Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.52Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
18.52Single6TP6Filorexant6TP6-OX1-Filorexant
18.52Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.52Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
18.52Single7C4SS1P7C4S-S1P3-S1P
18.52Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.52Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.52Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.52Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.52Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
18.52Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.52Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8S4DCMF-0198S4D-Apelin-CMF-019
18.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.52Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
18.52Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
18.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.52Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
18.52Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
18.52Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
18.52Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
18.52Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.52Consensusblt_offOrthosteric Ligandblt1_off
18.52Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.42Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
18.18Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.18Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.18Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
18.18Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
18.18Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
18.18Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.18Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.18Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.18Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
18.18Consensussensory_onOrthosteric Ligandopsins_on
17.95Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
17.95Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.86Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
17.86Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
17.86Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.86Single5XRAAM115425XRA-CB1-AM11542
17.86Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.86Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.86Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.86Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.86Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
17.86Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.86Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.86Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.86Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
17.86Single8EA0Iperoxo8EA0-M3-Iperoxo
17.86Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.86Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
17.86Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.86Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
17.86Single8XVLZibotentan8XVL-ETA-Zibotentan
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
17.86Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.86Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
17.86Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.86Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.78Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
17.65Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.65Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.65Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.65Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.65Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.65Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.50Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.39Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.39Single3OE6IT1t3OE6-CXCR4-IT1t
17.39Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
17.39Single4XNWMRS25004XNW-P2Y1-MRS2500
17.39Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.39Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
17.39Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.39Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.39Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.39Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.39Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.39Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
17.39Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.39Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.39Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.39Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.39Consensus5ht2_onOrthosteric Ligand5ht2b_on
17.39Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.24Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
17.24Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
17.24Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.24Consensusalpha1_offOrthosteric Ligandalpha1a_off
17.24Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
17.24Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.14Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.07Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
16.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
16.67Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
16.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
16.67Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
16.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
16.67Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.67Single7SRQLSD7SRQ-5-HT2B-LSD
16.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
16.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
16.67Single8K5BNiacin8K5B-HCA2-Niacin
16.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
16.67Single8XVJMacitentan8XVJ-ETA-Macitentan
16.67Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
16.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
16.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.22Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.22Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.22Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.22Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.22Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.22Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.22Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.13Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.13Single8IEIA1LYA8IEI-GPR156-A1LYA
16.13Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.13Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single3ODUIT1t3ODU-CXCR4-IT1t
16.00Single4QINSAG1.54QIN-SMO-SAG1.5
16.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
16.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.00Single5WS3EMPA5WS3-OX2-EMPA
16.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
16.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.00Single6TODEMPA6TOD-OX1-EMPA-Na
16.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
16.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
16.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
16.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
16.00Single7XRRLemborexant7XRR-OX2-Lemborexant
16.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
16.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
16.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
16.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.00Single8IWESpermidine8IWE-TA9-Spermidine
16.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
16.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
16.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
16.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
16.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
16.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.79Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.79Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
15.79Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
15.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.62Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
15.62Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.62Single8WKYPG-9348WKY-MC4-PG-934
15.62Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.38Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.38Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.38Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.38Single6IQLL7458706IQL-D4-L745870
15.38Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.38Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.38Single6TPKRetosiban6TPK-OT-Retosiban
15.38Single6V9SGTPL114036V9S-OX1-GTPL11403
15.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.38Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
15.38Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.38Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
15.38Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
15.38Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.38Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.38Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.38Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.38Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.38Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
15.38Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.38Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.38Single8K2WAMG4878K2W-CXCR3-AMG487
15.38Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.38Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
15.38Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
15.38Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.38Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.38Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.38Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.38Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.38Consensusgrh_offOrthosteric Ligandgnrh1_off
15.38Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.38Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.38Consensusvasop-oxy_offOrthosteric Ligandot_off
15.15Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.15Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.00Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
14.81Single4DAJTiotropium4DAJ-M3-Tiotropium
14.81Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
14.81Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
14.81Single4YAYZD-71554YAY-AT1-ZD-7155
14.81Single5DHGC-355DHG-NOP-C-35
14.81Single5DSGTiotropium5DSG-M4-Tiotropium
14.81Single5T04Neurotensin5T04-NTS1-Neurotensin
14.81Single5TGZAM65385TGZ-CB1-AM6538
14.81Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.81Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.81Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.81Single6FFHFenobam6FFH-mGlu5-Fenobam
14.81Single6GPSMK08126GPS-CCR2-MK0812
14.81Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
14.81Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
14.81Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
14.81Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.81Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.81Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
14.81Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
14.81Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
14.81Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.81Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.81Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.81Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
14.81Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.81Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.71Single6W25SHU91196W25-MC4-SHU9119-Ca
14.63Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.63Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single4JKVTaladegib4JKV-SMO-Taladegib
14.29Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6HLPNetupitant6HLP-NK1-Netupitant
14.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
14.29Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7SINNPS-21437SIN-CaS-NPS-2143
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7WC6LSD7WC6-5-HT2A-LSD
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.29Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
14.29Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
14.29Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.29Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
14.29Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.29Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.89Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.89Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.89Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.89Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.79Single5V56TC1145V56-SMO-TC114
13.79Single5V57TC1145V57-SMO-TC114
13.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.79Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
13.79Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.79Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.79Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
13.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.64Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
13.64Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
13.64Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.64Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.64Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.33Single5X33BIIL2605X33-BLT1-BIIL260
13.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
13.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.33Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.33Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.04Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.04Single3RFMCaffeine3RFM-A2A-Caffeine
13.04Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.04Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.04Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
13.04Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.04Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
13.04Single9CHUNoradrenaline9CHU-β2-Noradrenaline
13.04Consensusp2y_offOrthosteric Ligandp2y1_off
12.90Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.90Single5CGDHTL142425CGD-mGlu5-HTL14242
12.90Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.90Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.50Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
12.50Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
12.50Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusgi_sensoryOrthosteric Ligandgi_opsins
12.50Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
12.50Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
12.50Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.50Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.12Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
12.12Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single5L7IVismodegib5L7I-SMO-Vismodegib
12.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
12.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
12.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
12.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
12.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
12.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
12.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
12.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
12.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
12.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.76Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.63Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.54Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.54Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.54Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.54Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.54Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
11.54Single7F8ULintitript7F8U-CCKA-Lintitript
11.54Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.54Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.54Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.54Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
11.54Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.54Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
11.54Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
11.54Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.54Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
11.54Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.54Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.54Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.54Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.54Consensusangiotensin_offOrthosteric Ligandat1_off
11.54Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.54Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
11.54Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
11.54Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
11.43Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.43Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.11Single6TP3Nemorexant6TP3-OX1-Nemorexant
11.11Single6VI4JDTic6VI4-κ-JDTic
11.11Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
11.11Single6ZINSR486926ZIN-NTS1-SR48692
11.11Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.11Single7VV6C48/807VV6-MRGPRX2-C48/80
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.11Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
11.11Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.11Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
11.11Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single4QIMANTA XV4QIM-SMO-ANTA XV
10.71Single5DHHSB-6121115DHH-NOP-SB-612111
10.71Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.71Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.71Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
10.34Single5CGCHTL142425CGC-mGlu5-HTL14242
10.34Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.34Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.34Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.34Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.34Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.34Single6Z4SSR486926Z4S-NTS1-SR48692
10.34Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.34Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
10.34Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
10.34Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.34Consensusep_offOrthosteric Ligandep4_off
10.26Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
10.00Single7P2L4YI7P2L-mGlu5-4YI
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single9BJKNAM9BJK-μ-Naloxone-NAM
10.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
9.68Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.68Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
9.68Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.68Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
9.38Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.38Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.38Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
9.09Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
9.09Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.82Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.70Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.70Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.57Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.33Single3OE8IT1t3OE8-CXCR4-IT1t
8.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.00Single3UZAGTPL92363UZA-A2A-GTPL9236
8.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
8.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
8.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
8.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single6LI0C176LI0-GPR52-C17
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.69Single7UL2SR486927UL2-NTS1-SR48692-Na
7.69Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.69Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.69Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single9B9Y7DY9B9Y-CB1-7DY
7.69Consensusneurotensin_offOrthosteric Ligandnts1_off
7.69Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
7.41Single4K5YCP-3763954K5Y-CRF1-CP-376395
7.41Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
7.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.41Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.41Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
7.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.41Single9BA0A1AKN9BA0-CB1-A1AKN
7.14Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8IYXYL-3658IYX-GPR34-YL-365
7.14Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
6.90Single4Z9GCP-3763954Z9G-CRF1-CP-376395
6.90Single6IIVDaltroban6IIV-TP-Daltroban
6.90Single8GTIBMK-C2058GTI-CRF1-BMK-C205
6.90Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
6.90Single9B9ZA1AKO9B9Z-CB1-A1AKO
6.90Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
6.90Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
6.90Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
6.67Single8GTGBMK-I1528GTG-CRF1-BMK-I152
6.67Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
6.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.67Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.67Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
6.25Single6IIURamatroban6IIU-TP-Ramatroban
6.25Single8GTMBMK-C2038GTM-CRF1-BMK-C203
6.06Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.06Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
5.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.35Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8HS2Fab0468HS2-GPR20-Fab046
4.17Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.85Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.85Single8JPSCCL78JPS-ACKR1-CCL7
3.70Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
3.70Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.70Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.70Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single5U09Taranabant5U09-CB1-Taranabant
3.57Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.45Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
3.33Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
3.12Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
3.12Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.03Single7SHEPI; PE7SHE-GPR158-PI; PE
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7WVY 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
7T6U 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7VFX 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7T6V 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
7WVX 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
7T6S 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6OMM 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
Net Summary
Imin 3.11143
Number of Linked Nodes 890
Number of Links 1070
Number of Hubs 168
Number of Links mediated by Hubs 655
Number of Communities 23
Number of Nodes involved in Communities 233
Number of Links involved in Communities 336
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 2517866
Length Of Smallest Path 3
Average Path Length 41.3562
Length of Longest Path 73
Minimum Path Strength 0.428571
Average Path Strength 6.85913
Maximum Path Strength 21.4043
Minimum Path Correlation 0.7
Average Path Correlation 0.979059
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.44928
Average % Of Corr. Nodes 31.579
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.0363
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_peptidegi_cck
gi_apelin
gi_compl-pept
gi_endothelin
gi_formylpeptide
gi_galanin
gi_ghrelin
gi_npy
gi_neurotensin
gi_opioid
gi_orexin
gi_relaxin
gi_somatostatin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_formylpeptide.zip



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