Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y36 4.95415
2R:R:L39 6.7875417
3R:R:N50 5.8675409
4R:R:F60 3.7125405
5R:R:S73 6.6275419
6R:R:F79 4.16407
7R:R:V81 4.2325417
8R:R:G82 3.1775417
9R:R:V85 5.422517
10R:R:M86 4.18857717
11R:R:S89 5.005416
12R:R:R92 4.53415
13R:R:W98 3.42429718
14R:R:H108 4.538515
15R:R:D112 8.2975416
16R:R:T113 6.382514
17R:R:S114 3.95515
18R:R:F115 4.922517
19R:R:F117 3.95515
20R:R:L120 4.2925417
21R:R:F121 3.218515
22R:R:H122 6.832518
23R:R:Y131 11.675408
24R:R:Y140 5.08167627
25R:R:F144 8.9125426
26R:R:I153 4.7325418
27R:R:W157 3.11111919
28R:R:Y163 5.5615
29R:R:I167 5.22415
30R:R:F168 5.3825815
31R:R:Y169 5.2975405
32R:R:N173 4.5825414
33R:R:E174 5.525414
34R:R:P193 4.815413
35R:R:L194 4.1825414
36R:R:F203 2.5475406
37R:R:F206 8.0525418
38R:R:P209 5.3075419
39R:R:L216 6.9775406
40R:R:Y217 4.852539
41R:R:I220 3.2925409
42R:R:F221 2.0275405
43R:R:E232 5.44504
44R:R:K246 2.85475
45R:R:F267 4.825409
46R:R:W271 5.93571718
47R:R:Y274 5.544516
48R:R:I275 5.85417
49R:R:D281 4.245483
50R:R:Y293 4.0125404
51R:R:W298 6.56833615
52R:R:Y301 7.71429718
53R:R:A305 1.9975447
54R:R:N307 6.048519
55R:R:Y311 5.004519
56R:R:Y315 6.67458
57R:R:F318 4.694509
58L:L:?1 7.64222910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:C186 R:R:C22 49.36837.28NoNo038
2R:R:C22 R:R:V187 51.87725.12NoNo083
3R:R:A183 R:R:C186 46.85041.81NoNo023
4R:R:A183 R:R:K24 44.32353.21NoNo025
5R:R:K24 R:R:S96 41.78763.06NoNo053
6R:R:S96 R:R:Y27 31.55473.82NoNo031
7R:R:Y27 R:R:Y291 26.38449.93NoNo012
8R:R:G188 R:R:V187 54.37721.84NoNo043
9R:R:G188 R:R:W98 59.35041.41NoYes048
10R:R:H108 R:R:W98 66.97133.17YesYes158
11R:R:H108 R:R:S89 37.54.18YesYes156
12R:R:S89 R:R:W298 16.37543.71YesYes165
13R:R:H108 R:R:V85 45.19279.69YesYes157
14R:R:V85 R:R:Y301 23.78585.05YesYes178
15R:R:M86 R:R:Y301 40.71684.79YesYes178
16R:R:G82 R:R:M86 16.51435.24YesYes177
17R:R:A46 R:R:G82 13.79481.95NoYes077
18R:R:A305 R:R:A46 11.85041.79YesNo077
19R:R:S89 R:R:Y301 23.20798.9YesYes168
20R:R:M86 R:R:W298 23.74553.49YesYes175
21R:R:D78 R:R:S304 50.31818.83NoNo099
22R:R:M86 R:R:S304 46.50993.07YesNo179
23R:R:D78 R:R:N307 52.93912.69NoYes099
24R:R:N307 R:R:Y311 1006.98YesYes199
25R:R:I126 R:R:Y311 98.1724.84NoYes099
26R:R:I126 R:R:V71 96.89961.54NoNo098
27R:R:I57 R:R:V71 95.47941.54NoNo078
28R:R:F318 R:R:I57 92.79125.02YesNo097
29R:R:A312 R:R:F318 37.36564.16NoYes079
30R:R:A312 R:R:V53 35.47943.39NoNo079
31R:R:F313 R:R:V53 33.58423.93NoNo059
32R:R:F313 R:R:I322 31.680112.56NoNo057
33R:R:A56 R:R:I322 23.9741.62NoNo077
34R:R:A321 R:R:A56 22.02511.79NoNo077
35R:R:A321 R:R:F60 20.05824.16NoYes075
36R:R:F60 R:R:L324 12.13713.65YesNo054
37R:R:F115 R:R:W157 14.3284.01YesYes179
38R:R:I153 R:R:W157 16.11112.35YesYes189
39R:R:G150 R:R:I153 20.69891.76NoYes048
40R:R:G150 R:R:S149 19.90141.86NoNo047
41R:R:F69 R:R:S149 19.11742.64NoNo057
42R:R:F69 R:R:V146 16.75183.93NoNo053
43R:R:P66 R:R:V146 15.98573.53NoNo063
44R:R:P66 R:R:T65 15.39873.5NoNo068
45R:R:T65 R:R:T67 24.26974.71NoNo088
46R:R:F318 R:R:N68 16.18734.83YesNo099
47R:R:T67 R:R:Y140 13.67382.5NoYes287
48R:R:H122 R:R:W157 10.10754.23YesYes189
49R:R:H122 R:R:L74 17.64786.43YesNo189
50R:R:L74 R:R:N307 11.38449.61NoYes199
51R:R:D112 R:R:V85 18.46334.38YesYes167
52R:R:E294 R:R:R92 11.415810.47NoYes045
53R:R:D112 R:R:T113 11.97134.34YesYes164
54R:R:F168 R:R:T113 12.39710.38YesYes154
55R:R:C110 R:R:F168 13.16761.4NoYes065
56R:R:C110 R:R:Y169 10.99464.03NoYes065
57L:L:?1 R:R:F168 33.68737.43YesYes105
58L:L:?1 R:R:Y301 32.76885.11YesYes108
59R:R:T113 R:R:Y163 14.18014.99YesYes145
60R:R:S164 R:R:T113 13.61113.2NoYes074
61R:R:S114 R:R:S164 13.45884.89YesNo057
62L:L:?1 R:R:C116 23.57082.77YesNo007
63R:R:E294 R:R:Y293 11.84143.37NoYes044
64R:R:Y274 R:R:Y293 13.91131.99YesYes064
65R:R:I275 R:R:Y274 12.32533.63YesYes176
66R:R:V300 R:R:W271 29.33249.81NoYes178
67L:L:?1 R:R:V300 23.45436.49YesNo107
68R:R:C116 R:R:W271 23.22582.61NoYes078
69R:R:F117 R:R:Y163 20.45257.22YesYes155
70R:R:F117 R:R:F121 16.51883.22YesYes155
71R:R:F267 R:R:W271 10.47048.02YesYes098
72R:R:H122 R:R:S156 12.02069.76YesNo087
73R:R:F121 R:R:S156 11.8283.96YesNo057
74R:R:F121 R:R:F159 11.62192.14YesNo054
75R:R:F318 R:R:W317 49.82537.02YesNo096
76R:R:W317 R:R:Y315 46.061817.36NoYes568
77R:R:R130 R:R:Y315 40.74823.09NoYes098
78R:R:I220 R:R:R130 38.89792.51YesNo099
79R:R:I220 R:R:Y217 19.72222.42YesYes099
80R:R:I220 R:R:Y131 13.98753.63YesYes098
81R:R:F168 R:R:N173 16.73397.25YesYes154
82L:L:?1 R:R:A192 15.93192.75YesNo104
83R:R:A192 R:R:P193 16.79661.87NoYes143
84R:R:N195 R:R:W198 10.33156.78NoNo046
85R:R:I310 R:R:Y311 10.11654.84NoYes089
86R:R:N303 R:R:W271 61.88623.39NoYes098
87R:R:N303 R:R:S270 15.85574.47NoNo098
88R:R:C299 R:R:S270 10.60483.44NoNo078
89R:R:P289 R:R:Y291 23.78589.74NoNo042
90R:R:P289 R:R:T288 18.56183.5NoNo046
91R:R:D281 R:R:T288 10.622810.12YesNo836
92R:R:N68 R:R:T65 14.6647.31NoNo098
93R:R:F117 R:R:W271 19.78492YesYes158
94R:R:N303 R:R:N307 52.69712.72NoYes099
95R:R:S114 R:R:W157 11.65322.47YesYes159
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S89 R:R:V85 3.23 1 Yes Yes 6 7 2 2
R:R:D112 R:R:V85 4.38 1 Yes Yes 6 7 1 2
R:R:V85 R:R:Y301 5.05 1 Yes Yes 7 8 2 1
R:R:M86 R:R:W298 3.49 1 Yes Yes 7 5 2 2
R:R:M86 R:R:Y301 4.79 1 Yes Yes 7 8 2 1
R:R:S89 R:R:W298 3.71 1 Yes Yes 6 5 2 2
R:R:S89 R:R:Y301 8.9 1 Yes Yes 6 8 2 1
R:R:F168 R:R:T109 5.19 1 Yes No 5 5 1 2
R:R:D112 R:R:T113 4.34 1 Yes Yes 6 4 1 1
R:R:D112 R:R:Y301 12.64 1 Yes Yes 6 8 1 1
L:L:?1 R:R:D112 11.83 1 Yes Yes 0 6 0 1
R:R:T113 R:R:Y163 4.99 1 Yes Yes 4 5 1 2
R:R:S164 R:R:T113 3.2 0 No Yes 7 4 2 1
R:R:F168 R:R:T113 10.38 1 Yes Yes 5 4 1 1
L:L:?1 R:R:T113 9 1 Yes Yes 0 4 0 1
R:R:C116 R:R:W271 2.61 0 No Yes 7 8 1 2
L:L:?1 R:R:C116 2.77 1 Yes No 0 7 0 1
R:R:I167 R:R:Y163 6.04 1 Yes Yes 5 5 2 2
R:R:F168 R:R:I167 3.77 1 Yes Yes 5 5 1 2
R:R:F168 R:R:N173 7.25 1 Yes Yes 5 4 1 2
R:R:A192 R:R:F168 2.77 1 No Yes 4 5 1 1
R:R:F168 R:R:L194 4.87 1 Yes Yes 5 4 1 2
L:L:?1 R:R:F168 7.43 1 Yes Yes 0 5 0 1
R:R:L194 R:R:N173 4.12 1 Yes Yes 4 4 2 2
R:R:A192 R:R:P193 1.87 1 No Yes 4 3 1 2
L:L:?1 R:R:A192 2.75 1 Yes No 0 4 0 1
R:R:I275 R:R:W271 4.7 1 Yes Yes 7 8 2 2
R:R:V300 R:R:W271 9.81 1 No Yes 7 8 1 2
R:R:I275 R:R:Y274 3.63 1 Yes Yes 7 6 2 1
R:R:A278 R:R:Y274 4 0 No Yes 5 6 2 1
R:R:Y274 R:R:Y293 1.99 1 Yes Yes 6 4 1 2
R:R:V300 R:R:Y274 3.79 1 No Yes 7 6 1 1
L:L:?1 R:R:Y274 14.31 1 Yes Yes 0 6 0 1
R:R:V297 R:R:Y293 5.05 1 No Yes 6 4 1 2
R:R:V297 R:R:Y301 8.83 1 No Yes 6 8 1 1
L:L:?1 R:R:V297 9.09 1 Yes No 0 6 0 1
R:R:W298 R:R:Y301 8.68 1 Yes Yes 5 8 2 1
L:L:?1 R:R:V300 6.49 1 Yes No 0 7 0 1
L:L:?1 R:R:Y301 5.11 1 Yes Yes 0 8 0 1
R:R:C110 R:R:F168 1.4 0 No Yes 6 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
70.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
63.64Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
63.64Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
63.64Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGVEpinephrine8GGV-β2-Epinephrine
63.64Single8GGWEpinephrine8GGW-β2-Epinephrine
63.64Single8GGXEpinephrine8GGX-β2-Epinephrine
63.64Single8GH0Epinephrine8GH0-β2-Epinephrine
63.64Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
63.64Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
63.64Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
63.64Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
63.64Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
61.54Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
61.54Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
60.00Single8GGREpinephrine8GGR-β2-Epinephrine
60.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
60.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
60.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Single2YDOAdenosine2YDO-A2A-Adenosine
58.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
58.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
58.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
58.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
58.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
58.33Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGIEpinephrine8GGI-β2-Epinephrine
58.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
58.33Single8GGTEpinephrine8GGT-β2-Epinephrine
58.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
58.33Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
58.33Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single2YDVNECA2YDV-A2A-NECA
57.14Single4UHRCGS216804UHR-A2A-CGS21680
57.14Single5G53NECA5G53-A2A-NECA-Gs
57.14Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
57.14Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
55.56Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
54.55Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
54.55Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
54.55Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGSEpinephrine8GGS-β2-Epinephrine
54.55Single8GGYEpinephrine8GGY-β2-Epinephrine
54.55Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
54.55Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single2Y04Salbutamol2Y04-β1-Salbutamol
53.85Single3NY8ICI 118-5513NY8-β2-ICI 118-551
53.85Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
53.85Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
53.85Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
53.85Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
53.85Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
53.85Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
53.85Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
53.85Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
53.85Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.85Single6H7MSalbutamol6H7M-β1-Salbutamol
53.85Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
53.85Single6PS1Timolol6PS1-β2-Timolol
53.85Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
53.85Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
53.85Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
53.85Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
53.85Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGJEpinephrine8GGJ-β2-Epinephrine
53.85Single8GGNEpinephrine8GGN-β2-Epinephrine
53.85Single8GGOEpinephrine8GGO-β2-Epinephrine
53.85Single8GGUEpinephrine8GGU-β2-Epinephrine
53.85Single8JJOAlprenolol8JJO-β2-Alprenolol
53.85Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
53.85Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
53.85Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
53.85Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
53.85Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensushistamine_onOrthosteric Ligandh1_on h4_on
53.85Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
53.85Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
53.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
53.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
50.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
50.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
50.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
50.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
50.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
50.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
50.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
50.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
50.00Single6KUXRS-799486KUX-α2a-RS-79948
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
50.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
50.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
50.00Single6PS6Timolol6PS6-β2-Timolol
50.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single6TP6Filorexant6TP6-OX1-Filorexant
50.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
50.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
50.00Single7XKAEpinephrine7XKA-β2-Epinephrine
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
50.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
50.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
50.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
50.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
50.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
50.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
50.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
50.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
50.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
50.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
50.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
50.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
50.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
50.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
50.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
50.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
50.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
50.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
50.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
50.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
50.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
50.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single4UG2CGS216804UG2-A2A-CGS21680
46.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
46.67Single4U15Tiotropium4U15-M3-Tiotropium
46.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
46.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
46.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
46.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
46.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
46.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
46.67Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
46.67Single6OL9Tiotropium6OL9-M5-Tiotropium
46.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
46.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
46.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
46.67Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
46.67Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
46.67Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
46.67Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
46.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
46.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
46.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
46.67Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
46.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
46.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
46.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
46.67Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
46.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
46.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
46.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
46.15Single4ZJCSB-6740424ZJC-OX1-SB-674042
46.15Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.15Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
46.15Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
46.15Single6TP3Nemorexant6TP3-OX1-Nemorexant
46.15Single6V9SGTPL114036V9S-OX1-GTPL11403
46.15Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
46.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.15Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
46.15Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
46.15Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
46.15Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GGKEpinephrine8GGK-β2-Epinephrine
46.15Single8GGMEpinephrine8GGM-β2-Epinephrine
46.15Single8GGPEpinephrine8GGP-β2-Epinephrine
46.15Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
46.15Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
46.15Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
46.15Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.15Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
46.15Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
46.15Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
46.15Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
46.15Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
45.45Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
45.45Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
45.45Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.45Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
44.44Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
44.44Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
43.75Single4AMIBucindolol4AMI-β1-Bucindolol
43.75Single4LDEBI1671074LDE-β2-BI167107
43.75Single5CXVTiotropium5CXV-M1-Tiotropium
43.75Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
43.75Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
43.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
43.75Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
43.75Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
43.75Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
43.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8JJ8Formoterol8JJ8-β2-Formoterol
43.75Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
43.75Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.75Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
42.86Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
42.86Single2Y01Dobutamine2Y01-β1-Dobutamine
42.86Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
42.86Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
42.86Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Single4DAJTiotropium4DAJ-M3-Tiotropium
42.86Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.86Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single4MQSIperoxo4MQS-M2-Iperoxo
42.86Single4U14Tiotropium4U14-M3-Tiotropium
42.86Single4YAYZD-71554YAY-AT1-ZD-7155
42.86Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
42.86Single5DSGTiotropium5DSG-M4-Tiotropium
42.86Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
42.86Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
42.86Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
42.86Single6TOTLemborexant6TOT-OX1-Lemborexant
42.86Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single7BU7BI1671077BU7-β1-BI167107
42.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
42.86Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
42.86Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
42.86Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
42.86Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
42.86Single7UL4Alvimopan7UL4-μ-Alvimopan
42.86Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
42.86Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
42.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
42.86Single7WC7Lisuride7WC7-5-HT2A-Lisuride
42.86Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
42.86Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
42.86Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
42.86Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
42.86Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
42.86Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
42.86Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
42.86Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
42.86Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
42.86Consensusadenosine_onOrthosteric Liganda1_on a2_on
42.86Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
42.86Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
42.86Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
42.86Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.86Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
42.86Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
42.86Consensusgi_hcarOrthosteric Ligandgi_hca
42.86Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
42.86Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
42.86Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
42.86Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
42.86Consensusnucleotide_onOrthosteric Ligandadenosine_on
42.86Consensustar_onOrthosteric Ligandta1_on
42.11Single3QAKUK-4320973QAK-A2A-UK-432097
41.67Single3PBLEticlopride3PBL-D3-Eticlopride
41.67Single6HLLCP999946HLL-NK1-CP99994
41.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Single7SRQLSD7SRQ-5-HT2B-LSD
41.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
41.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single8GH1Epinephrine8GH1-β2-Epinephrine
41.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
41.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
41.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
41.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
41.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8K5BNiacin8K5B-HCA2-Niacin
41.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
41.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
41.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
41.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
41.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
41.18Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
41.18Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
41.18Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
41.18Single6H7LDobutamine6H7L-β1-Dobutamine
41.18Single6IBLArformoterol6IBL-β1-Arformoterol
41.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
41.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
41.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
41.18Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
41.18Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
41.18Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
41.18Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
40.00Single2Y00Dobutamine2Y00-β1-Dobutamine
40.00Single5C1MBU725C1M-μ-BU72
40.00Single5TVNLSD5TVN-5-HT2B-LSD
40.00Single5WF5UK-4320975WF5-A2A-UK-432097
40.00Single5WIUNemonapride5WIU-D4-Nemonapride
40.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
40.00Single5WQCEMPA5WQC-OX2-EMPA
40.00Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
40.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
40.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
40.00Single7WC6LSD7WC6-5-HT2A-LSD
40.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
40.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
40.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
40.00Single8EA0Iperoxo8EA0-M3-Iperoxo
40.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
40.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
40.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
40.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
40.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
40.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
40.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
40.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
40.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89Single3NY9PubChem 9131033NY9-β2-PubChem 913103
38.89Single7SK9CCX6627SK9-ACKR3-CCX662
38.89Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
38.89Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single5WS3EMPA5WS3-OX2-EMPA
38.46Single6AKXA4R6AKX-CCR5-A4R
38.46Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.46Single6ME2Ramelteon6ME2-MT1-Ramelteon
38.46Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
38.46Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
38.46Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
38.46Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
38.46Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
38.46Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
38.46Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
38.46Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
38.46Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
38.46Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.50Single3P0GBI1671073P0G-β2-BI167107
37.50Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
37.50Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
37.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
37.50Single5V54Methiothepin5V54-5-HT1B-Methiothepin
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single6J20Aprepitant6J20-NK1-Aprepitant
37.50Single6J21Aprepitant6J21-NK1-Aprepitant
37.50Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
37.50Single6WGTLSD6WGT-5-HT2A-LSD
37.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
37.50Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
37.50Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
37.50Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
37.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
37.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
37.50Single8E0GBU728E0G-μ-BU72
37.50Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
37.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
37.50Consensus5ht1_offOrthosteric Ligand5ht1b_off
37.50Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
37.50Consensus5ht5_offOrthosteric Ligand5ht5a_off
37.50Consensusa2_onOrthosteric Liganda2a_on a2b_on
37.50Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
37.50Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
37.50Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
37.50Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
37.50Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
37.50Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
37.50Consensushistamine_offOrthosteric Ligandh1_off
37.50Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
37.50Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
36.84Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
36.84Single4IARErgotamine4IAR-5-HT1B-Ergotamine
36.84Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.84Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
36.84Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.84Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
36.36Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
36.36Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
36.36Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensussensory_onOrthosteric Ligandopsin_on
35.71Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.71Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
35.71Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.71Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
35.71Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
35.71Single6A94Zotepine6A94-5-HT2A-Zotepine
35.71Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.71Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.71Single6TPGEMPA6TPG-OX2-EMPA
35.71Single6TPNHTL66416TPN-OX2-HTL6641
35.71Single6VI4JDTic6VI4-κ-JDTic
35.71Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.71Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.71Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
35.71Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
35.71Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.71Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.71Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.71Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8GGLEpinephrine8GGL-β2-Epinephrine
35.71Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.71Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
35.71Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
35.71Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.71Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
35.71Single8K5CAcipimox8K5C-HCA2-Acipimox
35.71Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
35.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.71Consensus5ht5_onOrthosteric Ligand5ht5a_on
35.71Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
35.71Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
35.71Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.71Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.71Consensushcar_onOrthosteric Ligandhca_on
35.29Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
35.29Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.29Single6A93Risperidone6A93-5-HT2A-Risperidone
35.29Single6CM4Risperidone6CM4-D2-Risperidone
35.29Single6MXTSalmeterol6MXT-β2-Salmeterol
35.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
35.29Single7DFPSpiperone7DFP-D2-Spiperone
35.29Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
35.29Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.29Single7K15MKD0467K15-BLT1-MKD046-Na
35.29Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.29Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
35.29Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single7YITNalfurafine7YIT-κ-Nalfurafine
35.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.29Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
35.29Single8JJLOlodaterol8JJL-β2-Olodaterol
35.29Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
35.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
35.29Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
35.29Consensusblt_offOrthosteric Ligandblt1_off
35.29Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
35.29Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.29Consensusgs_steroidOrthosteric Ligandgs_bileacid
35.29Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
35.29Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.29Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
35.29Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
35.29Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single6HLOAprepitant6HLO-NK1-Aprepitant
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single2Y02Carmoterol2Y02-β1-Carmoterol
33.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
33.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
33.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7EZCUKA7EZC-A2A-UKA
33.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
33.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
33.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
33.33Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
33.33Single8X63Mepyramine8X63-H1-Mepyramine
33.33Single8X64Desloratadine8X64-H1-Desloratadine
33.33Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
33.33Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
33.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
33.33Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
33.33Consensusleuko_onOrthosteric Ligandblt_on
33.33Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
32.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
31.82Single7C61Ergotamine7C61-5-HT1B-Ergotamine
31.58Single5WF6UK-4320975WF6-A2A-UK-432097
31.58Single5ZTYAM102575ZTY-CB2-AM10257
31.58Single6PT3DPI-2876PT3-δ-DPI-287
31.58Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
31.58Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7XN9L-054,5227XN9-SST2-L-054,522
31.58Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single8X5YAstemizole8X5Y-H1-Astemizole
31.58Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.58Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.25Single5CGCHTL142425CGC-mGlu5-HTL14242
31.25Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
31.25Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.25Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.25Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
31.25Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7SINNPS-21437SIN-CaS-NPS-2143
31.25Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.25Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
30.77Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
30.77Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
30.77Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
30.77Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
30.77Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
30.77Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.77Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
30.77Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.77Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
30.77Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
30.77Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
30.77Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
30.43Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
30.43Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
30.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.00Single7F8XNN90567F8X-CCKA-NN9056
30.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
30.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.41Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
29.41Single4DJHJDTic4DJH-κ-JDTic
29.41Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
29.41Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
29.41Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
29.41Single5X93K-87945X93-ETB-K-8794
29.41Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
29.41Single6E59L-7607356E59-NK1-L-760735
29.41Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.41Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
29.41Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
29.41Single7W41PD1762527W41-BB2-PD176252
29.41Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
29.41Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.41Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
29.41Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
29.41Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
29.41Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
29.41Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
29.41Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
29.41Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.41Consensusbombesin_offOrthosteric Ligandbb2_off
29.41Consensuscck_onOrthosteric Ligandccka_on cckb_on
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
29.41Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.17Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.57Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
28.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
28.57Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
28.57Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
28.57Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
28.57Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single6B73PubChem 1319551386B73-κ-PubChem 131955138
28.57Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.57Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
28.57Single7F8ULintitript7F8U-CCKA-Lintitript
28.57Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
28.57Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
28.57Single7XRRLemborexant7XRR-OX2-Lemborexant
28.57Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
28.57Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
28.57Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.57Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
28.57Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusgt_class-aOrthosteric Ligandgt_opsin
28.57Consensusgt_opsinOrthosteric Ligandgt_sensory
28.57Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
28.57Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single6HLPNetupitant6HLP-NK1-Netupitant
27.78Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
27.78Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.78Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.78Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
27.78Single8JWZAB9288JWZ-A2A-AB928-Na
27.78Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.78Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
27.78Consensusdp_offOrthosteric Liganddp2_off
27.78Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.78Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
27.27Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
27.27Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single6PT2KGCHM076PT2-δ-KGCHM07
27.27Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Single7WC4Serotonin7WC4-5-HT2A-Serotonin
27.27Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
27.27Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
27.27Consensusangiotensin_onOrthosteric Ligandat1_on
27.27Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
27.27Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
27.27Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
26.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.67Single3RZECidoxepin3RZE-H1-Cidoxepin
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single6FFIMMPEP6FFI-mGlu5-MMPEP
26.67Single6IQLL7458706IQL-D4-L745870
26.67Single6TPKRetosiban6TPK-OT-Retosiban
26.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
26.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.67Single7T32ZM2413857T32-A2A-ZM241385
26.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
26.67Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
26.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.67Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
26.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.67Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
26.67Consensuss1p_offOrthosteric Ligands1p1_off
26.67Consensussensory_offOrthosteric Ligandopsin_off
26.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single5CGDHTL142425CGD-mGlu5-HTL14242
26.32Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
26.32Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.32Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
26.32Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
26.32Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
26.32Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
26.32Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.32Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.32Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
26.32Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
26.32Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusorexin_onOrthosteric Ligandox2_on
26.32Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.09Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
25.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6FFHFenobam6FFH-mGlu5-Fenobam
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
24.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
23.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.81Consensusclass-d_offOrthosteric Ligandste2_off
23.81Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensussst_onOrthosteric Ligandsst2_on sst4_on
23.53Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.53Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.53Single5XPRBosentan5XPR-ETB-Bosentan
23.53Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
23.53Single6GPXMK08126GPX-CCR2-MK0812
23.53Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.53Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7C4SS1P7C4S-S1P3-S1P
23.53Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
23.53Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
23.53Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.53Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.08Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.08Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
23.08Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.08Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
23.08Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.73Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
22.73Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
22.73Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.73Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
22.73Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
22.22Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single7EPENAM5637EPE-mGlu-NAM563
22.22Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
22.22Single7P2L4YI7P2L-mGlu5-4YI
22.22Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.22Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.22Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
22.22Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
22.22Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
22.22Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.22Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
22.22Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
22.22Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
22.22Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.22Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
22.22Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.22Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
22.22Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
22.22Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
22.22Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.22Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
21.74Single3OE0CVX153OE0-CXCR4-CVX15
21.74Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.74Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.74Single6W25SHU91196W25-MC4-SHU9119-Ca
21.74Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.74Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
21.43Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.43Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
21.43Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
21.43Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.43Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.43Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.43Consensusgo_class-b2Orthosteric Ligandgo_adhesion
21.43Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
21.05Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.05Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
21.05Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
21.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Consensusclass-b2_onOrthosteric Ligandadgrg_on
21.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.05Consensusgi_class-fOther Ligandgi_frizzled
21.05Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
21.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
21.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
20.83Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.83Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.83Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.83Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.83Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.83Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.83Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.83Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
20.69Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.00Single5K2DZM2413855K2D-A2A-ZM241385
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5U09Taranabant5U09-CB1-Taranabant
20.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
20.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
20.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
20.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
20.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
20.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
20.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
20.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
20.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
20.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.35Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
19.35Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
19.35Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.35Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
19.23Single6FJ3PTH6FJ3-PTH1-PTH
19.23Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
19.23Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
19.23Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
19.23Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
19.23Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
19.05Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
19.05Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
19.05Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
19.05Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
19.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
19.05Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensuslpl_offOrthosteric Ligands1p_off lpa_off
19.05Consensuslpl_onOrthosteric Ligands1p_on lpa_on
19.05Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
19.05Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.75Single3REYPubChem 56973REY-A2A-PubChem 5697
18.75Single5IU4ZM2413855IU4-A2A-ZM241385-Na
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5JTBZM2413855JTB-A2A-ZM241385
18.75Single5K2BZM2413855K2B-A2A-ZM241385-Na
18.75Single5K2CZM2413855K2C-A2A-ZM241385-Na
18.75Single5NLXZM2413855NLX-A2A-ZM241385-Na
18.75Single5NM4ZM2413855NM4-A2A-ZM241385-Na
18.75Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
18.75Single6AQFZM2413856AQF-A2A-ZM241385
18.75Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
18.75Single6MH8ZM2413856MH8-A2A-ZM241385
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
18.75Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.75Single7VODCariprazine7VOD-5-HT2A-Cariprazine
18.75Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.75Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.75Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
18.75Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.75Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.52Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.52Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
18.52Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.52Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
18.52Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.52Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
18.52Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.52Consensusgo_class-b1Orthosteric Ligandgo_crf
18.52Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single4XT1Fractalkine4XT1-US28-Fractalkine
18.18Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.18Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
18.18Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
18.18Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
18.18Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.18Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
17.86Single6IGLIRL16206IGL-ETB-IRL1620
17.86Single6LMLGlucagon6LML-Glucagon-Glucagon
17.86Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
17.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.86Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.86Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
17.86Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.86Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.65Single3EMLZM2413853EML-A2A-ZM241385
17.65Single4EIYZM2413854EIY-A2A-ZM241385-Na
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5K2AZM2413855K2A-A2A-ZM241385-Na
17.65Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.65Single5OLGZM2413855OLG-A2A-ZM241385-Na
17.65Single5VRAZM2413855VRA-A2A-ZM241385-Na
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6IIVDaltroban6IIV-TP-Daltroban
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single6LPJZM2413856LPJ-A2A-ZM241385-Na
17.65Single6LPKZM2413856LPK-A2A-ZM241385-Na
17.65Single6S0LZM2413856S0L-A2A-ZM241385
17.65Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
17.65Single7F83PF-051904577F83-Ghrelin-PF-05190457
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
17.65Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
17.65Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
17.65Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
17.65Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
17.65Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.65Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensusa2_offOrthosteric Liganda2a_off
17.65Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
17.65Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.65Consensuscck_offOrthosteric Ligandccka_off
17.65Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
17.65Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.65Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.65Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.65Consensushcar_offOrthosteric Ligandsuccinate_off
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.65Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
17.65Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.65Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
17.39Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.39Single7SK5CXCL127SK5-ACKR3-CXCL12
17.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.39Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.39Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
17.39Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
17.39Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
17.39Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
17.24Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.24Single6IGKEndothelin-36IGK-ETB-Endothelin-3
17.24Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
17.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.24Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
16.67Single6LPLZM2413856LPL-A2A-ZM241385-Na
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single6S0QZM2413856S0Q-A2A-ZM241385
16.67Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.67Single6WQAZM2413856WQA-A2A-ZM241385-Na
16.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
16.67Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
16.67Single7RM5ZM2413857RM5-A2A-ZM241385-Na
16.67Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.67Single8FYNZM2413858FYN-A2A-ZM241385-Na
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
16.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single8QOTNanobody E8QOT-μ-Nanobody E
16.67Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
16.67Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.67Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.67Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.67Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.22Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
16.13Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.13Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
16.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.00Consensusclass-d_onOrthosteric Ligandste2_on
16.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.00Consensusgi_class-dOrthosteric Ligandgi_ste
16.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
15.79Single5TZR-5TZR-FFA1 (GPR40)-MK8666
15.79Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
15.79Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.79Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
15.79Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.79Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.79Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Consensuslpa_offOrthosteric Ligandlpa1_off
15.79Consensuslpa_onOrthosteric Ligandlpa1_on
15.79Consensusrelaxin_onOrthosteric Ligandrxfp4_on
15.62Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.62Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
15.38Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
15.38Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.38Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
15.38Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
15.38Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.38Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.38Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.15Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.00Single5X33BIIL2605X33-BLT1-BIIL260
15.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.00Single6IIURamatroban6IIU-TP-Ramatroban
15.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
15.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
15.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
15.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.81Single4XT3Fractalkine4XT3-US28-Fractalkine
14.81Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.81Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
14.81Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.81Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.81Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
14.29Single6K1QIRL25006K1Q-ETB-IRL2500
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
14.29Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
14.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
14.29Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
14.29Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
14.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
14.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
14.29Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
14.29Consensusendothelin_onOrthosteric Ligandetb_on eta_on
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.79Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
13.79Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.79Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.64Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.64Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.64Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.64Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.64Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
13.64Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.64Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.64Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.04Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
13.04Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.04Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
13.04Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
13.04Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.04Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
13.04Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.90Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.50Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
12.50Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.50Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.50Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensussst_offOrthosteric Ligandsst2_off
12.12Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
12.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
12.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
12.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
11.76Single5UVIZM2413855UVI-A2A-ZM241385
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.76Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
11.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Single8K2WAMG4878K2W-CXCR3-AMG487
11.76Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.76Consensusgnrh_offOrthosteric Ligandgnrh1_off
11.54Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.54Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.54Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.54Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.54Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.11Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.11Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.11Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusclass-c_offOther Ligandgabab_off mglu_off
11.11Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
11.11Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.11Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.81Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.71Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.71Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7SK3CXCL127SK3-ACKR3-CXCL12
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.71Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.53Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.34Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.34Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.34Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
10.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
10.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
10.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.52Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.52Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
9.52Single6OS2TRV0266OS2-AT1-TRV026
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.52Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.52Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
9.52Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.38Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.09Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.09Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.70Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
8.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.70Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
8.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
8.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.00Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.69Consensusclass-c_onOther Ligandgabab_on mglu_on
7.69Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.14Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
6.67Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.45Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.45Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.25Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
6.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.25Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.25Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Consensusclass-t_onOrthosteric Ligandtaste2_on
6.25Consensusgs_class-tOrthosteric Ligandgs_taste
6.25Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.25Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.25Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.88Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.88Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.88Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
5.88Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.56Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.56Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.56Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.56Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IYXYL-3658IYX-GPR34-YL-365
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.26Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
5.26Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.26Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.26Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.26Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single5V56TC1145V56-SMO-TC114
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.76Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
4.76Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
4.76Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.55Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.55Single4XESNeurotensin4XES-NTS1-Neurotensin
4.55Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.55Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.55Consensuschemokine_offOrthosteric Ligandcxcr_off
4.55Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.55Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.55Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.55Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.55Consensusnts_offOrthosteric Ligandnts1_off
4.35Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.35Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.35Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.17Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.17Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.63Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

PDB Summary
PDB 8IWE
Class A
SubFamily Orphan
Type A orphans
SubType TAAR9
Species Mus Musculus
Ligand Spermidine
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.4
Date 2023-05-31
D.O.I. 10.1038/s41586-023-06106-4
Net Summary
Imin 1.76
Number of Linked Nodes 285
Number of Links 342
Number of Hubs 58
Number of Links mediated by Hubs 214
Number of Communities 8
Number of Nodes involved in Communities 79
Number of Links involved in Communities 119
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 62690
Length Of Smallest Path 3
Average Path Length 13.6335
Length of Longest Path 38
Minimum Path Strength 1.185
Average Path Strength 4.76484
Maximum Path Strength 16.905
Minimum Path Correlation 0.7
Average Path Correlation 0.932723
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 53.1484
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.785
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSPD
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeSPD
NameSpermidine
SynonymsN-(3-Aminopropyl)-1,4-butane-diamine
IdentifierN-(3-aminopropyl)butane-1,4-diamine
FormulaC7 H19 N3
Molecular Weight145.246
SMILESC(CCNCCCN)CN
PubChem1102
Formal Charge0
Total Atoms29
Total Chiral Atoms0
Total Bonds28
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ5QD04
Sequence
>8IWE_Chain_R
CIKSSYAPW PRAILYGVL GLGALLAVF GNLLVIIAI LHFKQLHTP 
TNFLVASLA CADFLVGVT VMPFSTVRS VESCWYFGE SYCKFHTCF 
DTSFCFASL FHLCCISID RYIAVTDPL TYPTKFTVS VSGLCIALS 
WFFSVTYSF SIFYTGANE EGIEELVAL TCVGGCQAP LNQNWVLLC 
FLLFFLPTV VMVFLYGRI FLVAKYQAR KIEGYKERV AKRERKAAK 
TLGIAMAAF LVSWLPYII DAVIDAYMN FITPAYVYE ILVWCVYYN 
SAMNPLIYA FFYPWFRKA IKLIVSGK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ITFAOrphanA orphansTAAR9Mus musculusDMCHA-chim(NtGi1-Gs)/&β;1/&γ;23.462023-05-3110.1038/s41586-023-06106-4
8IW1AOrphanA orphansTAAR9Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;23.42023-05-3110.1038/s41586-023-06106-4
8IW4AOrphanA orphansTAAR9Mus musculusSpermidine-chim(NtGi1-Gs)/&β;1/&γ;23.492023-05-3110.1038/s41586-023-06106-4
8IW7AOrphanA orphansTAAR9Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;22.972023-05-3110.1038/s41586-023-06106-4
8IW9AOrphanA orphansTAAR9Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;23.082023-05-3110.1038/s41586-023-06106-4
8IWEAOrphanA orphansTAAR9Mus musculusSpermidine--3.42023-05-3110.1038/s41586-023-06106-4
8IWMAOrphanA orphansTAAR9Mus musculus2-Phenylethylamine--3.172023-05-3110.1038/s41586-023-06106-4




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