psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A33	R:R:Y36	6.67	No	Yes	0	5	5
2	R:R:L35	R:R:L39	4.15	No	No	0	5	7
3	R:R:V91	R:R:Y36	5.05	No	Yes	0	4	5
4	R:R:V94	R:R:Y36	7.57	No	Yes	0	6	5
5	R:R:L39	R:R:W298	15.94	No	Yes	0	7	5
6	R:R:G42	R:R:Y302	4.35	No	Yes	0	6	6
7	R:R:F48	R:R:L44	8.53	No	No	0	4	5
8	R:R:A46	R:R:D78	4.63	No	Yes	0	7	9
9	R:R:A75	R:R:N50	3.13	No	No	0	9	9
10	R:R:D78	R:R:N50	14.81	Yes	No	3	9	9
11	R:R:N50	R:R:P308	6.52	No	No	3	9	9
12	R:R:F79	R:R:L51	3.65	No	No	0	7	4
13	R:R:I57	R:R:V53	3.07	Yes	No	0	7	9
14	R:R:A75	R:R:V53	3.39	No	No	0	9	9
15	R:R:A75	R:R:I54	3.25	No	No	0	9	8
16	R:R:C76	R:R:I54	3.27	No	No	0	7	8
17	R:R:I325	R:R:I55	4.42	No	No	0	6	4
18	R:R:I57	R:R:V71	3.07	Yes	No	0	7	8
19	R:R:A72	R:R:I57	4.87	No	Yes	0	6	7
20	R:R:F318	R:R:I57	5.02	No	Yes	0	9	7
21	R:R:F60	R:R:H59	10.18	No	No	0	5	6
22	R:R:F60	R:R:I325	6.28	No	No	0	5	6
23	R:R:T65	R:R:T67	3.14	No	No	0	8	8
24	R:R:N68	R:R:T65	5.85	No	No	0	9	8
25	R:R:F144	R:R:P66	4.33	No	No	0	6	6
26	R:R:P66	R:R:V146	3.53	No	No	0	6	3
27	R:R:D129	R:R:T67	8.67	Yes	No	2	9	8
28	R:R:T67	R:R:Y140	3.75	No	Yes	2	8	7
29	R:R:F318	R:R:N68	7.25	No	No	0	9	9
30	R:R:F69	R:R:V146	5.24	No	No	0	5	3
31	R:R:F69	R:R:S149	5.28	No	No	0	5	7
32	R:R:C152	R:R:L70	6.35	No	No	0	6	8
33	R:R:H122	R:R:S73	5.58	Yes	No	0	8	9
34	R:R:I153	R:R:S73	12.39	No	No	0	8	9
35	R:R:H122	R:R:L74	5.14	Yes	No	0	8	9
36	R:R:L74	R:R:N307	6.87	No	No	0	9	9
37	R:R:D78	R:R:S304	10.31	Yes	No	0	9	9
38	R:R:D78	R:R:P308	6.44	Yes	No	3	9	9
39	R:R:F79	R:R:V83	7.87	No	No	0	7	4
40	R:R:F115	R:R:L80	12.18	Yes	No	0	7	7
41	R:R:G82	R:R:V81	3.68	No	No	5	7	7
42	R:R:M86	R:R:V81	3.04	Yes	No	5	7	7
43	R:R:C116	R:R:V81	3.42	No	No	0	7	7
44	R:R:G82	R:R:M86	5.24	No	Yes	5	7	7
45	R:R:T84	R:R:V83	3.17	No	No	0	5	4
46	R:R:T84	R:R:Y104	3.75	No	No	0	5	6
47	R:R:F111	R:R:T84	15.56	No	No	0	5	5
48	R:R:H108	R:R:V85	6.92	No	No	0	5	7
49	R:R:D112	R:R:V85	10.22	No	No	6	6	7
50	R:R:V85	R:R:Y301	5.05	No	Yes	6	7	8
51	R:R:F88	R:R:Y104	4.13	No	No	0	5	6
52	R:R:F88	R:R:H108	4.53	No	No	0	5	5
53	R:R:H108	R:R:S89	8.37	No	No	0	5	6
54	R:R:T90	R:R:W298	3.64	No	Yes	0	6	5
55	R:R:E95	R:R:V91	12.84	No	No	0	5	4
56	R:R:E294	R:R:S93	4.31	No	No	0	4	4
57	R:R:S93	R:R:W298	7.41	No	Yes	0	4	5
58	R:R:F100	R:R:W98	6.01	No	Yes	0	6	8
59	R:R:C105	R:R:W98	7.84	No	Yes	7	9	8
60	R:R:C190	R:R:W98	14.37	No	Yes	7	9	8
61	R:R:F107	R:R:Y104	7.22	No	No	0	5	6
62	R:R:C105	R:R:C190	7.28	No	No	7	9	9
63	R:R:F168	R:R:T109	3.89	Yes	No	0	5	5
64	R:R:Q191	R:R:T109	7.09	No	No	0	1	5
65	R:R:F111	R:R:F115	23.58	No	Yes	0	5	7
66	R:R:C116	R:R:D112	6.22	No	No	0	7	6
67	R:R:D112	R:R:Y301	12.64	No	Yes	6	6	8
68	R:R:F168	R:R:T113	7.78	Yes	No	0	5	4
69	R:R:S114	R:R:S160	3.26	Yes	No	0	5	8
70	R:R:S114	R:R:V161	3.23	Yes	No	0	5	3
71	R:R:S114	R:R:S164	4.89	Yes	No	0	5	7
72	R:R:F115	R:R:W157	3.01	Yes	Yes	0	7	9
73	R:R:F117	R:R:Y163	4.13	No	Yes	0	5	5
74	R:R:F117	R:R:L205	3.65	No	No	0	5	4
75	R:R:F117	R:R:W271	6.01	No	Yes	0	5	8
76	R:R:A118	R:R:S160	3.42	No	No	0	7	8
77	R:R:L120	R:R:P209	3.28	No	No	0	7	9
78	R:R:F267	R:R:L120	3.65	Yes	No	1	9	7
79	R:R:L120	R:R:W271	10.25	No	Yes	1	7	8
80	R:R:F121	R:R:F159	4.29	No	No	0	5	4
81	R:R:F121	R:R:L205	6.09	No	No	0	5	4
82	R:R:H122	R:R:S156	8.37	Yes	No	4	8	7
83	R:R:H122	R:R:W157	4.23	Yes	Yes	4	8	9
84	R:R:L123	R:R:N307	4.12	No	No	0	8	9
85	R:R:L123	R:R:Y311	5.86	No	Yes	0	8	9
86	R:R:C124	R:R:P209	3.77	No	No	0	7	9
87	R:R:C124	R:R:V212	3.42	No	No	0	7	6
88	R:R:C125	R:R:C152	7.28	No	No	0	6	6
89	R:R:L216	R:R:S127	4.5	No	No	0	6	8
90	R:R:S127	R:R:Y217	3.82	No	No	0	8	9
91	R:R:D129	R:R:R130	4.76	Yes	No	0	9	9
92	R:R:D129	R:R:Y140	5.75	Yes	Yes	2	9	7
93	R:R:D129	R:R:F144	13.14	Yes	No	2	9	6
94	R:R:R130	R:R:Y315	3.09	No	No	0	9	8
95	R:R:T135	R:R:Y131	17.48	No	No	0	6	8
96	R:R:L216	R:R:Y131	7.03	No	No	0	6	8
97	R:R:R219	R:R:Y131	6.17	No	No	0	4	8
98	R:R:A133	R:R:Y140	6.67	No	Yes	0	8	7
99	R:R:I220	R:R:V134	9.22	No	No	0	9	8
100	R:R:V134	R:R:V223	3.21	No	No	0	8	5
101	R:R:D136	R:R:P137	3.22	No	No	0	6	8
102	R:R:D136	R:R:T139	5.78	No	No	0	6	5
103	R:R:T139	R:R:T142	3.14	No	No	0	5	4
104	R:R:K143	R:R:T139	7.51	No	No	0	4	5
105	R:R:P141	R:R:Y140	4.17	No	Yes	0	4	7
106	R:R:F144	R:R:Y140	7.22	No	Yes	2	6	7
107	R:R:S147	R:R:T145	4.8	No	No	0	4	7
108	R:R:G150	R:R:S149	3.71	No	No	0	4	7
109	R:R:G150	R:R:I153	3.53	No	No	0	4	8
110	R:R:F159	R:R:L155	3.65	No	No	0	4	2
111	R:R:S156	R:R:W157	3.71	No	Yes	4	7	9
112	R:R:F158	R:R:T162	5.19	No	No	0	4	4
113	R:R:I167	R:R:Y163	18.13	No	Yes	0	5	5
114	R:R:F165	R:R:Y169	5.16	No	No	0	4	5
115	R:R:F168	R:R:I167	12.56	Yes	No	0	5	5
116	R:R:I167	R:R:W198	7.05	No	No	0	5	6
117	R:R:F168	R:R:L194	3.65	Yes	No	0	5	4
118	R:R:G171	R:R:T170	3.64	No	No	0	1	5
119	R:R:N195	R:R:W198	13.56	No	No	0	4	6
120	R:R:A282	R:R:Q196	3.03	No	No	0	4	2
121	R:R:N197	R:R:W198	10.17	No	No	0	4	6
122	R:R:F203	R:R:I275	7.54	No	No	0	6	7
123	R:R:F203	R:R:V279	3.93	No	No	0	6	6
124	R:R:F206	R:R:F207	4.29	Yes	No	0	8	4
125	R:R:F206	R:R:T210	7.78	Yes	No	1	8	6
126	R:R:F206	R:R:F267	3.22	Yes	Yes	1	8	9
127	R:R:F206	R:R:W271	11.02	Yes	Yes	1	8	8
128	R:R:F206	R:R:I275	5.02	Yes	No	0	8	7
129	R:R:L208	R:R:P209	3.28	No	No	0	5	9
130	R:R:F267	R:R:T210	9.08	Yes	No	1	9	6
131	R:R:M213	R:R:M264	4.33	No	Yes	0	8	8
132	R:R:F267	R:R:M213	7.46	Yes	No	0	9	8
133	R:R:M264	R:R:V214	3.04	Yes	No	0	8	5
134	R:R:L260	R:R:Y217	9.38	No	No	0	7	9
135	R:R:M264	R:R:Y217	4.79	Yes	No	0	8	9
136	R:R:I220	R:R:L260	4.28	No	No	0	9	7
137	R:R:V223	R:R:Y226	8.83	No	Yes	0	5	5
138	R:R:K225	R:R:R229	3.71	No	No	0	5	4
139	R:R:E253	R:R:K225	4.05	No	No	0	7	5
140	R:R:R229	R:R:Y226	3.09	No	Yes	0	4	5
141	R:R:A228	R:R:R252	4.15	No	No	0	4	6
142	R:R:E232	R:R:I231	8.2	Yes	No	0	4	7
143	R:R:E232	R:R:R248	5.82	Yes	No	0	4	3
144	R:R:E232	R:R:R252	3.49	Yes	No	0	4	6
145	R:R:E247	R:R:Y245	3.37	No	No	0	4	3
146	R:R:R248	R:R:Y245	10.29	No	No	0	3	3
147	R:R:K251	R:R:R248	7.43	No	No	0	5	3
148	R:R:K258	R:R:R254	3.71	No	No	0	7	4
149	R:R:K255	R:R:K258	5.75	No	No	0	8	7
150	R:R:F314	R:R:T259	7.78	No	No	0	7	8
151	R:R:F267	R:R:L268	7.31	Yes	No	0	9	6
152	R:R:F267	R:R:W271	3.01	Yes	Yes	1	9	8
153	R:R:L268	R:R:L272	6.92	No	No	0	6	6
154	R:R:V300	R:R:W271	7.36	No	Yes	0	7	8
155	R:R:N303	R:R:W271	7.91	No	Yes	0	9	8
156	R:R:I276	R:R:L272	4.28	No	No	0	6	6
157	R:R:L296	R:R:Y274	3.52	No	No	0	5	6
158	R:R:V300	R:R:Y274	3.79	No	No	0	7	6
159	R:R:D277	R:R:D281	7.98	No	Yes	0	5	3
160	R:R:D277	R:R:L296	5.43	No	No	0	5	5
161	R:R:D281	R:R:I280	5.6	Yes	No	0	3	4
162	R:R:D281	R:R:F286	14.33	Yes	No	8	3	2
163	R:R:D281	R:R:T288	4.34	Yes	No	8	3	6
164	R:R:F286	R:R:T288	22.05	No	No	8	2	6
165	R:R:I287	R:R:P289	10.16	No	No	0	3	4
166	R:R:P289	R:R:V292	7.07	No	No	0	4	5
167	R:R:W298	R:R:Y301	3.86	Yes	Yes	0	5	8
168	R:R:A305	R:R:Y302	6.67	No	Yes	0	7	6
169	R:R:N303	R:R:N307	6.81	No	No	0	9	9
170	R:R:F313	R:R:L309	3.65	No	No	0	5	6
171	R:R:I310	R:R:Y311	9.67	No	Yes	0	8	9
172	R:R:F313	R:R:I322	5.02	No	Yes	0	5	7
173	R:R:F314	R:R:Y315	3.09	No	No	0	7	8
174	R:R:W317	R:R:Y315	15.43	No	No	0	6	8
175	R:R:P316	R:R:W317	9.46	No	No	0	4	6
176	R:R:F318	R:R:W317	8.02	No	No	0	9	6
177	R:R:L70	R:R:S149	3	No	No	0	8	7
178	R:R:L74	R:R:S119	3	No	No	0	9	9
179	R:R:R92	R:R:W98	3	No	Yes	0	5	8
180	R:R:K258	R:R:T259	3	No	No	0	7	8
181	R:R:L194	R:R:V199	2.98	No	No	0	4	5
182	R:R:N303	R:R:S270	2.98	No	No	0	9	8
183	R:R:I262	R:R:I310	2.94	No	No	0	6	8
184	R:R:P316	R:R:R319	2.88	No	No	0	4	8
185	R:R:I322	R:R:L52	2.85	Yes	No	0	7	7
186	R:R:I128	R:R:L216	2.85	No	No	0	7	6
187	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
188	R:R:A256	R:R:F221	2.77	No	No	0	8	5
189	R:R:A257	R:R:F221	2.77	No	No	0	7	5
190	R:R:L63	R:R:N68	2.75	No	No	0	8	9
191	R:R:C202	R:R:Y163	2.69	No	Yes	0	5	5
192	R:R:A263	R:R:Y311	2.67	No	Yes	0	8	9
193	R:R:L63	R:R:Q62	2.66	No	No	0	8	6
194	R:R:F115	R:R:S114	2.64	Yes	Yes	0	7	5
195	R:R:F165	R:R:S164	2.64	No	No	0	4	7
196	R:R:F48	R:R:V47	2.62	No	No	0	4	6
197	R:R:F79	R:R:V47	2.62	No	No	0	7	6
198	R:R:A77	R:R:W157	2.59	No	Yes	0	8	9
199	R:R:V297	R:R:Y293	2.52	No	No	0	6	4
200	R:R:F60	R:R:L324	2.44	No	No	0	5	4
201	R:R:I126	R:R:Y311	2.42	No	Yes	0	9	9
202	R:R:I132	R:R:Y140	2.42	No	Yes	0	5	7
203	R:R:K106	R:R:Y169	2.39	No	No	0	6	5
204	R:R:M306	R:R:Y302	2.39	No	Yes	0	5	6
205	R:R:L201	R:R:Y163	2.34	No	Yes	0	5	5
206	R:R:F69	R:R:H64	2.26	No	No	0	5	7
207	R:R:A192	R:R:P193	1.87	No	No	0	4	3
208	R:R:G328	R:R:S327	1.86	No	No	0	4	6
209	R:R:A321	R:R:A56	1.79	No	No	0	7	7
210	R:R:G261	R:R:M264	1.75	No	Yes	0	5	8
211	R:R:P289	R:R:T288	1.75	No	No	0	4	6
212	R:R:C110	R:R:S164	1.72	No	No	0	6	7
213	R:R:G49	R:R:L52	1.71	No	No	0	8	7
214	R:R:A312	R:R:V53	1.7	No	No	0	7	9
215	R:R:M86	R:R:P87	1.68	Yes	No	0	7	8
216	R:R:L272	R:R:P273	1.64	No	No	0	6	9
217	R:R:A56	R:R:I322	1.62	No	Yes	0	7	7
218	R:R:A56	R:R:I325	1.62	No	No	0	7	6
219	R:R:S93	R:R:V94	1.62	No	No	0	4	6
220	R:R:S147	R:R:V148	1.62	No	No	0	4	6
221	R:R:S244	R:R:V249	1.62	No	No	0	3	4
222	R:R:A266	R:R:I310	1.62	No	No	0	7	8
223	R:R:S270	R:R:V269	1.62	No	No	0	8	5
224	R:R:A43	R:R:M86	1.61	No	Yes	0	6	7
225	R:R:I322	R:R:V326	1.54	Yes	No	0	7	5
226	R:R:K323	R:R:S327	1.53	No	No	0	6	6
227	R:R:F48	R:R:G49	1.51	No	No	0	4	8
228	R:R:F221	R:R:G218	1.51	No	No	0	5	3
229	R:R:L39	R:R:V38	1.49	No	No	0	7	5
230	R:R:I280	R:R:M284	1.46	No	No	0	4	3
231	R:R:G37	R:R:Y36	1.45	No	Yes	0	4	5
232	R:R:D136	R:R:T135	1.45	No	No	0	6	6
233	R:R:E294	R:R:S96	1.44	No	No	0	4	3
234	R:R:I34	R:R:L35	1.43	No	No	0	5	5
235	R:R:I54	R:R:L58	1.43	No	No	0	8	4
236	R:R:I57	R:R:L58	1.43	Yes	No	0	7	4
237	R:R:E232	R:R:V249	1.43	Yes	No	0	4	4
238	R:R:E253	R:R:V249	1.43	No	No	0	7	4
239	R:R:P193	R:R:Y293	1.39	No	No	0	3	4
240	R:R:A257	R:R:R254	1.38	No	No	0	7	4
241	R:R:V297	R:R:Y301	1.26	No	Yes	0	6	8
242	R:R:I34	R:R:R32	1.25	No	No	0	5	4
243	R:R:L222	R:R:R219	1.21	No	No	0	3	4
244	R:R:M284	R:R:Y283	1.2	No	No	0	3	4
245	R:R:K230	R:R:Y226	1.19	No	Yes	0	3	5
246	R:R:L41	R:R:Y302	1.17	No	Yes	0	4	6
247	R:R:Q196	R:R:Y283	1.13	No	No	0	2	4
248	R:R:Q227	R:R:Y226	1.13	No	Yes	0	6	5
249	R:R:E95	R:R:Y99	1.12	No	No	0	5	2
250	R:R:E294	R:R:Y291	1.12	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y36	5.185	4	0	5
2	R:R:I57	3.492	5	0	7
3	R:R:D78	9.0475	4	3	9
4	R:R:M86	2.8925	4	5	7
5	R:R:W98	6.806	5	7	8
6	R:R:S114	3.505	4	0	5
7	R:R:F115	10.3525	4	0	7
8	R:R:H122	5.83	4	4	8
9	R:R:D129	8.08	4	2	9
10	R:R:Y140	4.99667	6	2	7
11	R:R:W157	3.385	4	4	9
12	R:R:Y163	6.8225	4	0	5
13	R:R:F168	6.97	4	0	5
14	R:R:F206	6.266	5	1	8
15	R:R:Y226	3.56	4	0	5
16	R:R:E232	4.735	4	0	4
17	R:R:M264	3.4775	4	0	8
18	R:R:F267	5.62167	6	1	9
19	R:R:W271	7.59333	6	1	8
20	R:R:D281	8.0625	4	8	3
21	R:R:W298	7.7125	4	0	5
22	R:R:Y301	5.7025	4	6	8
23	R:R:Y302	3.645	4	0	6
24	R:R:Y311	5.155	4	0	9
25	R:R:I322	2.7575	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S93	R:R:V94	10.9563	1.62	No	No	0	4	6
2	R:R:S93	R:R:W298	16.9136	7.41	No	Yes	0	4	5
3	R:R:W298	R:R:Y301	27.0504	3.86	Yes	Yes	0	5	8
4	R:R:V85	R:R:Y301	32.6861	5.05	No	Yes	6	7	8
5	R:R:H108	R:R:V85	44.0711	6.92	No	No	0	5	7
6	R:R:F88	R:R:H108	46.5927	4.53	No	No	0	5	5
7	R:R:F88	R:R:Y104	47.7968	4.13	No	No	0	5	6
8	R:R:T84	R:R:Y104	50.1797	3.75	No	No	0	5	6
9	R:R:T84	R:R:V83	28.7398	3.17	No	No	0	5	4
10	R:R:F79	R:R:V83	27.3404	7.87	No	No	0	7	4
11	R:R:F79	R:R:V47	24.5036	2.62	No	No	0	7	6
12	R:R:F48	R:R:V47	23.0663	2.62	No	No	0	4	6
13	R:R:F111	R:R:T84	71.2413	15.56	No	No	0	5	5
14	R:R:F111	R:R:F115	72.0734	23.58	No	Yes	0	5	7
15	R:R:F115	R:R:W157	81.2961	3.01	Yes	Yes	0	7	9
16	R:R:H122	R:R:W157	82.3804	4.23	Yes	Yes	4	8	9
17	R:R:H122	R:R:S73	93.3241	5.58	Yes	No	0	8	9
18	R:R:I153	R:R:S73	92.7693	12.39	No	No	0	8	9
19	R:R:G150	R:R:I153	92.202	3.53	No	No	0	4	8
20	R:R:G150	R:R:S149	91.622	3.71	No	No	0	4	7
21	R:R:F69	R:R:S149	89.1761	5.28	No	No	0	5	7
22	R:R:F69	R:R:V146	87.8774	5.24	No	No	0	5	3
23	R:R:P66	R:R:V146	87.2092	3.53	No	No	0	6	3
24	R:R:F144	R:R:P66	86.5284	4.33	No	No	0	6	6
25	R:R:D129	R:R:F144	57.9399	13.14	Yes	No	2	9	6
26	R:R:D129	R:R:T67	23.5264	8.67	Yes	No	2	9	8
27	R:R:T65	R:R:T67	44.9411	3.14	No	No	0	8	8
28	R:R:N68	R:R:T65	42.6968	5.85	No	No	0	9	8
29	R:R:F318	R:R:N68	36.0777	7.25	No	No	0	9	9
30	R:R:F318	R:R:I57	51.2703	5.02	No	Yes	0	9	7
31	R:R:I57	R:R:V53	29.4585	3.07	Yes	No	0	7	9
32	R:R:A75	R:R:V53	22.1837	3.39	No	No	0	9	9
33	R:R:A75	R:R:N50	18.5904	3.13	No	No	0	9	9
34	R:R:D78	R:R:N50	11.1706	14.81	Yes	No	3	9	9
35	R:R:F144	R:R:Y140	27.8888	7.22	No	Yes	2	6	7
36	R:R:T67	R:R:Y140	23.7219	3.75	No	Yes	2	8	7
37	R:R:D129	R:R:R130	34.2558	4.76	Yes	No	0	9	9
38	R:R:R130	R:R:Y315	33.203	3.09	No	No	0	9	8
39	R:R:W317	R:R:Y315	22.6943	15.43	No	No	0	6	8
40	R:R:F318	R:R:W317	19.2523	8.02	No	No	0	9	6
41	R:R:I57	R:R:L58	11.0509	1.43	Yes	No	0	7	4
42	R:R:F48	R:R:G49	20.1538	1.51	No	No	0	4	8
43	R:R:G49	R:R:L52	18.6787	1.71	No	No	0	8	7
44	R:R:I322	R:R:L52	17.1909	2.85	Yes	No	0	7	7
45	R:R:A56	R:R:I322	11.1139	1.62	No	Yes	0	7	7
46	R:R:H122	R:R:L74	100	5.14	Yes	No	0	8	9
47	R:R:L74	R:R:N307	99.2561	6.87	No	No	0	9	9
48	R:R:N303	R:R:N307	95.7763	6.81	No	No	0	9	9
49	R:R:N303	R:R:W271	94.2634	7.91	No	Yes	0	9	8
50	R:R:F117	R:R:W271	26.7667	6.01	No	Yes	0	5	8
51	R:R:F117	R:R:Y163	19.5991	4.13	No	Yes	0	5	5
52	R:R:I167	R:R:Y163	15.388	18.13	No	Yes	0	5	5
53	R:R:F115	R:R:S114	14.102	2.64	Yes	Yes	0	7	5
54	R:R:F267	R:R:W271	55.3678	3.01	Yes	Yes	1	9	8
55	R:R:L123	R:R:N307	11.1139	4.12	No	No	0	8	9
56	R:R:F267	R:R:M213	51.3333	7.46	Yes	No	0	9	8
57	R:R:M213	R:R:M264	50.1671	4.33	No	Yes	0	8	8
58	R:R:M264	R:R:Y217	46.5927	4.79	Yes	No	0	8	9
59	R:R:S127	R:R:Y217	18.603	3.82	No	No	0	8	9
60	R:R:L216	R:R:S127	17.1216	4.5	No	No	0	6	8
61	R:R:L216	R:R:Y131	14.1209	7.03	No	No	0	6	8
62	R:R:L260	R:R:Y217	29.7926	9.38	No	No	0	7	9
63	R:R:I220	R:R:L260	28.3994	4.28	No	No	0	9	7
64	R:R:I220	R:R:V134	26.9999	9.22	No	No	0	9	8
65	R:R:V134	R:R:V223	25.6887	3.21	No	No	0	8	5
66	R:R:D277	R:R:D281	17.1909	7.98	No	Yes	0	5	3
67	R:R:D277	R:R:L296	18.6787	5.43	No	No	0	5	5
68	R:R:L296	R:R:Y274	20.1538	3.52	No	No	0	5	6
69	R:R:V300	R:R:Y274	21.6163	3.79	No	No	0	7	6
70	R:R:V300	R:R:W271	23.0663	7.36	No	Yes	0	7	8
71	R:R:V223	R:R:Y226	24.2766	8.83	No	Yes	0	5	5
72	R:R:R229	R:R:Y226	19.9458	3.09	No	Yes	0	4	5
73	R:R:K225	R:R:R229	18.477	3.71	No	No	0	5	4
74	R:R:E253	R:R:K225	16.9892	4.05	No	No	0	7	5
75	R:R:E232	R:R:V249	12.589	1.43	Yes	No	0	4	4
76	R:R:E253	R:R:V249	15.6213	1.43	No	No	0	7	4
77	R:R:F314	R:R:Y315	12.0469	3.09	No	No	0	7	8
78	R:R:F314	R:R:T259	10.7294	7.78	No	No	0	7	8
79	R:R:D112	R:R:V85	10.0927	10.22	No	No	6	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8IW1_nogp

PDB Summary
PDB	8IW1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	244
Number of Links	250
Number of Hubs	25
Number of Links mediated by Hubs	101
Number of Communities	8
Number of Nodes involved in Communities	27
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	31006
Length Of Smallest Path	3
Average Path Length	19.1666
Length of Longest Path	41
Minimum Path Strength	1.16
Average Path Strength	6.03233
Maximum Path Strength	19.57
Minimum Path Correlation	0.7
Average Path Correlation	0.930639
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	40.0992
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	24.3023
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to amine • response to chemical • response to nitrogen compound • response to amphetamine • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to purine-containing compound • response to caffeine • response to alkaloid • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD04
Sequence	>8IW1_nogp_Chain_R P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F K Q L H T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S C W Y F G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D P L T Y P T K F T V S V S G L C I A L S W F F S V T Y S F S I F Y T G C Q A P L N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G S Y K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M N F I T P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W F R K A I K L I V S G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ITF	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-	chim(NtGi1-Gs)/β1/γ2	3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8ITF (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-		3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	chim(NtGi1-Gs)/β1/γ2	3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-		3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-		2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWE	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	-	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWM	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	-	3.17	2023-05-31	doi.org/10.1038/s41586-023-06106-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IW1_nogp.zip

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