psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A33	R:R:Y36	6.67	No	Yes	0	5	5
2	R:R:L35	R:R:L39	4.15	No	No	0	5	7
3	R:R:V91	R:R:Y36	5.05	No	Yes	0	4	5
4	R:R:V94	R:R:Y36	7.57	No	Yes	0	6	5
5	R:R:L39	R:R:W298	15.94	No	Yes	0	7	5
6	R:R:G42	R:R:Y302	4.35	No	Yes	0	6	6
7	R:R:F48	R:R:L44	8.53	No	No	0	4	5
8	R:R:A46	R:R:D78	4.63	No	Yes	0	7	9
9	R:R:A75	R:R:N50	3.13	No	No	0	9	9
10	R:R:D78	R:R:N50	14.81	Yes	No	3	9	9
11	R:R:N50	R:R:P308	6.52	No	No	3	9	9
12	R:R:F79	R:R:L51	3.65	No	No	0	7	4
13	R:R:I57	R:R:V53	3.07	Yes	No	0	7	9
14	R:R:A75	R:R:V53	3.39	No	No	0	9	9
15	R:R:A75	R:R:I54	3.25	No	No	0	9	8
16	R:R:C76	R:R:I54	3.27	No	No	0	7	8
17	R:R:I325	R:R:I55	4.42	No	No	0	6	4
18	R:R:I57	R:R:V71	3.07	Yes	No	0	7	8
19	R:R:A72	R:R:I57	4.87	No	Yes	0	6	7
20	R:R:F318	R:R:I57	5.02	No	Yes	0	9	7
21	R:R:F60	R:R:H59	10.18	No	No	0	5	6
22	R:R:F60	R:R:I325	6.28	No	No	0	5	6
23	R:R:T65	R:R:T67	3.14	No	No	0	8	8
24	R:R:N68	R:R:T65	5.85	No	No	0	9	8
25	R:R:F144	R:R:P66	4.33	No	No	0	6	6
26	R:R:P66	R:R:V146	3.53	No	No	0	6	3
27	R:R:D129	R:R:T67	8.67	Yes	No	2	9	8
28	R:R:T67	R:R:Y140	3.75	No	Yes	2	8	7
29	R:R:F318	R:R:N68	7.25	No	No	0	9	9
30	R:R:F69	R:R:V146	5.24	No	No	0	5	3
31	R:R:F69	R:R:S149	5.28	No	No	0	5	7
32	R:R:C152	R:R:L70	6.35	No	No	0	6	8
33	R:R:H122	R:R:S73	5.58	Yes	No	0	8	9
34	R:R:I153	R:R:S73	12.39	No	No	0	8	9
35	R:R:H122	R:R:L74	5.14	Yes	No	0	8	9
36	R:R:L74	R:R:N307	6.87	No	No	0	9	9
37	R:R:D78	R:R:S304	10.31	Yes	No	0	9	9
38	R:R:D78	R:R:P308	6.44	Yes	No	3	9	9
39	R:R:F79	R:R:V83	7.87	No	No	0	7	4
40	R:R:F115	R:R:L80	12.18	Yes	No	0	7	7
41	R:R:G82	R:R:V81	3.68	No	No	5	7	7
42	R:R:M86	R:R:V81	3.04	Yes	No	5	7	7
43	R:R:C116	R:R:V81	3.42	No	No	0	7	7
44	R:R:G82	R:R:M86	5.24	No	Yes	5	7	7
45	R:R:T84	R:R:V83	3.17	No	No	0	5	4
46	R:R:T84	R:R:Y104	3.75	No	No	0	5	6
47	R:R:F111	R:R:T84	15.56	No	No	0	5	5
48	R:R:H108	R:R:V85	6.92	No	No	0	5	7
49	R:R:D112	R:R:V85	10.22	No	No	6	6	7
50	R:R:V85	R:R:Y301	5.05	No	Yes	6	7	8
51	R:R:F88	R:R:Y104	4.13	No	No	0	5	6
52	R:R:F88	R:R:H108	4.53	No	No	0	5	5
53	R:R:H108	R:R:S89	8.37	No	No	0	5	6
54	R:R:T90	R:R:W298	3.64	No	Yes	0	6	5
55	R:R:E95	R:R:V91	12.84	No	No	0	5	4
56	R:R:E294	R:R:S93	4.31	No	No	0	4	4
57	R:R:S93	R:R:W298	7.41	No	Yes	0	4	5
58	R:R:F100	R:R:W98	6.01	No	Yes	0	6	8
59	R:R:C105	R:R:W98	7.84	No	Yes	7	9	8
60	R:R:C190	R:R:W98	14.37	No	Yes	7	9	8
61	R:R:F107	R:R:Y104	7.22	No	No	0	5	6
62	R:R:C105	R:R:C190	7.28	No	No	7	9	9
63	R:R:F168	R:R:T109	3.89	Yes	No	0	5	5
64	R:R:Q191	R:R:T109	7.09	No	No	0	1	5
65	R:R:F111	R:R:F115	23.58	No	Yes	0	5	7
66	R:R:C116	R:R:D112	6.22	No	No	0	7	6
67	R:R:D112	R:R:Y301	12.64	No	Yes	6	6	8
68	R:R:F168	R:R:T113	7.78	Yes	No	0	5	4
69	R:R:S114	R:R:S160	3.26	Yes	No	0	5	8
70	R:R:S114	R:R:V161	3.23	Yes	No	0	5	3
71	R:R:S114	R:R:S164	4.89	Yes	No	0	5	7
72	R:R:F115	R:R:W157	3.01	Yes	Yes	0	7	9
73	R:R:F117	R:R:Y163	4.13	No	Yes	0	5	5
74	R:R:F117	R:R:L205	3.65	No	No	0	5	4
75	R:R:F117	R:R:W271	6.01	No	Yes	0	5	8
76	R:R:A118	R:R:S160	3.42	No	No	0	7	8
77	R:R:L120	R:R:P209	3.28	No	No	0	7	9
78	R:R:F267	R:R:L120	3.65	Yes	No	1	9	7
79	R:R:L120	R:R:W271	10.25	No	Yes	1	7	8
80	R:R:F121	R:R:F159	4.29	No	No	0	5	4
81	R:R:F121	R:R:L205	6.09	No	No	0	5	4
82	R:R:H122	R:R:S156	8.37	Yes	No	4	8	7
83	R:R:H122	R:R:W157	4.23	Yes	Yes	4	8	9
84	R:R:L123	R:R:N307	4.12	No	No	0	8	9
85	R:R:L123	R:R:Y311	5.86	No	Yes	0	8	9
86	R:R:C124	R:R:P209	3.77	No	No	0	7	9
87	R:R:C124	R:R:V212	3.42	No	No	0	7	6
88	R:R:C125	R:R:C152	7.28	No	No	0	6	6
89	R:R:L216	R:R:S127	4.5	No	No	0	6	8
90	R:R:S127	R:R:Y217	3.82	No	No	0	8	9
91	R:R:D129	R:R:R130	4.76	Yes	No	0	9	9
92	R:R:D129	R:R:Y140	5.75	Yes	Yes	2	9	7
93	R:R:D129	R:R:F144	13.14	Yes	No	2	9	6
94	R:R:R130	R:R:Y315	3.09	No	No	0	9	8
95	R:R:T135	R:R:Y131	17.48	No	No	0	6	8
96	R:R:L216	R:R:Y131	7.03	No	No	0	6	8
97	R:R:R219	R:R:Y131	6.17	No	No	0	4	8
98	R:R:A133	R:R:Y140	6.67	No	Yes	0	8	7
99	R:R:I220	R:R:V134	9.22	No	No	0	9	8
100	R:R:V134	R:R:V223	3.21	No	No	0	8	5
101	R:R:D136	R:R:P137	3.22	No	No	0	6	8
102	R:R:D136	R:R:T139	5.78	No	No	0	6	5
103	R:R:T139	R:R:T142	3.14	No	No	0	5	4
104	R:R:K143	R:R:T139	7.51	No	No	0	4	5
105	R:R:P141	R:R:Y140	4.17	No	Yes	0	4	7
106	R:R:F144	R:R:Y140	7.22	No	Yes	2	6	7
107	R:R:S147	R:R:T145	4.8	No	No	0	4	7
108	R:R:G150	R:R:S149	3.71	No	No	0	4	7
109	R:R:G150	R:R:I153	3.53	No	No	0	4	8
110	R:R:F159	R:R:L155	3.65	No	No	0	4	2
111	R:R:S156	R:R:W157	3.71	No	Yes	4	7	9
112	R:R:F158	R:R:T162	5.19	No	No	0	4	4
113	R:R:I167	R:R:Y163	18.13	No	Yes	0	5	5
114	R:R:F165	R:R:Y169	5.16	No	No	0	4	5
115	R:R:F168	R:R:I167	12.56	Yes	No	0	5	5
116	R:R:I167	R:R:W198	7.05	No	No	0	5	6
117	R:R:F168	R:R:L194	3.65	Yes	No	0	5	4
118	R:R:G171	R:R:T170	3.64	No	No	0	1	5
119	R:R:N195	R:R:W198	13.56	No	No	0	4	6
120	R:R:A282	R:R:Q196	3.03	No	No	0	4	2
121	R:R:N197	R:R:W198	10.17	No	No	0	4	6
122	R:R:F203	R:R:I275	7.54	No	No	0	6	7
123	R:R:F203	R:R:V279	3.93	No	No	0	6	6
124	R:R:F206	R:R:F207	4.29	Yes	No	0	8	4
125	R:R:F206	R:R:T210	7.78	Yes	No	1	8	6
126	R:R:F206	R:R:F267	3.22	Yes	Yes	1	8	9
127	R:R:F206	R:R:W271	11.02	Yes	Yes	1	8	8
128	R:R:F206	R:R:I275	5.02	Yes	No	0	8	7
129	R:R:L208	R:R:P209	3.28	No	No	0	5	9
130	R:R:F267	R:R:T210	9.08	Yes	No	1	9	6
131	R:R:M213	R:R:M264	4.33	No	Yes	0	8	8
132	R:R:F267	R:R:M213	7.46	Yes	No	0	9	8
133	R:R:M264	R:R:V214	3.04	Yes	No	0	8	5
134	R:R:L260	R:R:Y217	9.38	No	No	0	7	9
135	R:R:M264	R:R:Y217	4.79	Yes	No	0	8	9
136	R:R:I220	R:R:L260	4.28	No	No	0	9	7
137	R:R:V223	R:R:Y226	8.83	No	Yes	0	5	5
138	R:R:K225	R:R:R229	3.71	No	No	0	5	4
139	R:R:E253	R:R:K225	4.05	No	No	0	7	5
140	R:R:R229	R:R:Y226	3.09	No	Yes	0	4	5
141	R:R:A228	R:R:R252	4.15	No	No	0	4	6
142	R:R:E232	R:R:I231	8.2	Yes	No	0	4	7
143	R:R:E232	R:R:R248	5.82	Yes	No	0	4	3
144	R:R:E232	R:R:R252	3.49	Yes	No	0	4	6
145	R:R:E247	R:R:Y245	3.37	No	No	0	4	3
146	R:R:R248	R:R:Y245	10.29	No	No	0	3	3
147	R:R:K251	R:R:R248	7.43	No	No	0	5	3
148	R:R:K258	R:R:R254	3.71	No	No	0	7	4
149	R:R:K255	R:R:K258	5.75	No	No	0	8	7
150	R:R:F314	R:R:T259	7.78	No	No	0	7	8
151	R:R:F267	R:R:L268	7.31	Yes	No	0	9	6
152	R:R:F267	R:R:W271	3.01	Yes	Yes	1	9	8
153	R:R:L268	R:R:L272	6.92	No	No	0	6	6
154	R:R:V300	R:R:W271	7.36	No	Yes	0	7	8
155	R:R:N303	R:R:W271	7.91	No	Yes	0	9	8
156	R:R:I276	R:R:L272	4.28	No	No	0	6	6
157	R:R:L296	R:R:Y274	3.52	No	No	0	5	6
158	R:R:V300	R:R:Y274	3.79	No	No	0	7	6
159	R:R:D277	R:R:D281	7.98	No	Yes	0	5	3
160	R:R:D277	R:R:L296	5.43	No	No	0	5	5
161	R:R:D281	R:R:I280	5.6	Yes	No	0	3	4
162	R:R:D281	R:R:F286	14.33	Yes	No	8	3	2
163	R:R:D281	R:R:T288	4.34	Yes	No	8	3	6
164	R:R:F286	R:R:T288	22.05	No	No	8	2	6
165	R:R:I287	R:R:P289	10.16	No	No	0	3	4
166	R:R:P289	R:R:V292	7.07	No	No	0	4	5
167	R:R:W298	R:R:Y301	3.86	Yes	Yes	0	5	8
168	R:R:A305	R:R:Y302	6.67	No	Yes	0	7	6
169	R:R:N303	R:R:N307	6.81	No	No	0	9	9
170	R:R:F313	R:R:L309	3.65	No	No	0	5	6
171	R:R:I310	R:R:Y311	9.67	No	Yes	0	8	9
172	R:R:F313	R:R:I322	5.02	No	Yes	0	5	7
173	R:R:F314	R:R:Y315	3.09	No	No	0	7	8
174	R:R:W317	R:R:Y315	15.43	No	No	0	6	8
175	R:R:P316	R:R:W317	9.46	No	No	0	4	6
176	R:R:F318	R:R:W317	8.02	No	No	0	9	6
177	R:R:L70	R:R:S149	3	No	No	0	8	7
178	R:R:L74	R:R:S119	3	No	No	0	9	9
179	R:R:R92	R:R:W98	3	No	Yes	0	5	8
180	R:R:K258	R:R:T259	3	No	No	0	7	8
181	R:R:L194	R:R:V199	2.98	No	No	0	4	5
182	R:R:N303	R:R:S270	2.98	No	No	0	9	8
183	R:R:I262	R:R:I310	2.94	No	No	0	6	8
184	R:R:P316	R:R:R319	2.88	No	No	0	4	8
185	R:R:I322	R:R:L52	2.85	Yes	No	0	7	7
186	R:R:I128	R:R:L216	2.85	No	No	0	7	6
187	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
188	R:R:A256	R:R:F221	2.77	No	No	0	8	5
189	R:R:A257	R:R:F221	2.77	No	No	0	7	5
190	R:R:L63	R:R:N68	2.75	No	No	0	8	9
191	R:R:C202	R:R:Y163	2.69	No	Yes	0	5	5
192	R:R:A263	R:R:Y311	2.67	No	Yes	0	8	9
193	R:R:L63	R:R:Q62	2.66	No	No	0	8	6
194	R:R:F115	R:R:S114	2.64	Yes	Yes	0	7	5
195	R:R:F165	R:R:S164	2.64	No	No	0	4	7
196	R:R:F48	R:R:V47	2.62	No	No	0	4	6
197	R:R:F79	R:R:V47	2.62	No	No	0	7	6
198	R:R:A77	R:R:W157	2.59	No	Yes	0	8	9
199	R:R:V297	R:R:Y293	2.52	No	No	0	6	4
200	R:R:F60	R:R:L324	2.44	No	No	0	5	4
201	R:R:I126	R:R:Y311	2.42	No	Yes	0	9	9
202	R:R:I132	R:R:Y140	2.42	No	Yes	0	5	7
203	R:R:K106	R:R:Y169	2.39	No	No	0	6	5
204	R:R:M306	R:R:Y302	2.39	No	Yes	0	5	6
205	R:R:L201	R:R:Y163	2.34	No	Yes	0	5	5
206	R:R:F69	R:R:H64	2.26	No	No	0	5	7
207	R:R:A192	R:R:P193	1.87	No	No	0	4	3
208	R:R:G328	R:R:S327	1.86	No	No	0	4	6
209	R:R:A321	R:R:A56	1.79	No	No	0	7	7
210	R:R:G261	R:R:M264	1.75	No	Yes	0	5	8
211	R:R:P289	R:R:T288	1.75	No	No	0	4	6
212	R:R:C110	R:R:S164	1.72	No	No	0	6	7
213	R:R:G49	R:R:L52	1.71	No	No	0	8	7
214	R:R:A312	R:R:V53	1.7	No	No	0	7	9
215	R:R:M86	R:R:P87	1.68	Yes	No	0	7	8
216	R:R:L272	R:R:P273	1.64	No	No	0	6	9
217	R:R:A56	R:R:I322	1.62	No	Yes	0	7	7
218	R:R:A56	R:R:I325	1.62	No	No	0	7	6
219	R:R:S93	R:R:V94	1.62	No	No	0	4	6
220	R:R:S147	R:R:V148	1.62	No	No	0	4	6
221	R:R:S244	R:R:V249	1.62	No	No	0	3	4
222	R:R:A266	R:R:I310	1.62	No	No	0	7	8
223	R:R:S270	R:R:V269	1.62	No	No	0	8	5
224	R:R:A43	R:R:M86	1.61	No	Yes	0	6	7
225	R:R:I322	R:R:V326	1.54	Yes	No	0	7	5
226	R:R:K323	R:R:S327	1.53	No	No	0	6	6
227	R:R:F48	R:R:G49	1.51	No	No	0	4	8
228	R:R:F221	R:R:G218	1.51	No	No	0	5	3
229	R:R:L39	R:R:V38	1.49	No	No	0	7	5
230	R:R:I280	R:R:M284	1.46	No	No	0	4	3
231	R:R:G37	R:R:Y36	1.45	No	Yes	0	4	5
232	R:R:D136	R:R:T135	1.45	No	No	0	6	6
233	R:R:E294	R:R:S96	1.44	No	No	0	4	3
234	R:R:I34	R:R:L35	1.43	No	No	0	5	5
235	R:R:I54	R:R:L58	1.43	No	No	0	8	4
236	R:R:I57	R:R:L58	1.43	Yes	No	0	7	4
237	R:R:E232	R:R:V249	1.43	Yes	No	0	4	4
238	R:R:E253	R:R:V249	1.43	No	No	0	7	4
239	R:R:P193	R:R:Y293	1.39	No	No	0	3	4
240	R:R:A257	R:R:R254	1.38	No	No	0	7	4
241	R:R:V297	R:R:Y301	1.26	No	Yes	0	6	8
242	R:R:I34	R:R:R32	1.25	No	No	0	5	4
243	R:R:L222	R:R:R219	1.21	No	No	0	3	4
244	R:R:M284	R:R:Y283	1.2	No	No	0	3	4
245	R:R:K230	R:R:Y226	1.19	No	Yes	0	3	5
246	R:R:L41	R:R:Y302	1.17	No	Yes	0	4	6
247	R:R:Q196	R:R:Y283	1.13	No	No	0	2	4
248	R:R:Q227	R:R:Y226	1.13	No	Yes	0	6	5
249	R:R:E95	R:R:Y99	1.12	No	No	0	5	2
250	R:R:E294	R:R:Y291	1.12	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y36	5.185	4	0	5
2	R:R:I57	3.492	5	0	7
3	R:R:D78	9.0475	4	3	9
4	R:R:M86	2.8925	4	5	7
5	R:R:W98	6.806	5	7	8
6	R:R:S114	3.505	4	0	5
7	R:R:F115	10.3525	4	0	7
8	R:R:H122	5.83	4	4	8
9	R:R:D129	8.08	4	2	9
10	R:R:Y140	4.99667	6	2	7
11	R:R:W157	3.385	4	4	9
12	R:R:Y163	6.8225	4	0	5
13	R:R:F168	6.97	4	0	5
14	R:R:F206	6.266	5	1	8
15	R:R:Y226	3.56	4	0	5
16	R:R:E232	4.735	4	0	4
17	R:R:M264	3.4775	4	0	8
18	R:R:F267	5.62167	6	1	9
19	R:R:W271	7.59333	6	1	8
20	R:R:D281	8.0625	4	8	3
21	R:R:W298	7.7125	4	0	5
22	R:R:Y301	5.7025	4	6	8
23	R:R:Y302	3.645	4	0	6
24	R:R:Y311	5.155	4	0	9
25	R:R:I322	2.7575	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S93	R:R:V94	10.9563	1.62	No	No	0	4	6
2	R:R:S93	R:R:W298	16.9136	7.41	No	Yes	0	4	5
3	R:R:W298	R:R:Y301	27.0504	3.86	Yes	Yes	0	5	8
4	R:R:V85	R:R:Y301	32.6861	5.05	No	Yes	6	7	8
5	R:R:H108	R:R:V85	44.0711	6.92	No	No	0	5	7
6	R:R:F88	R:R:H108	46.5927	4.53	No	No	0	5	5
7	R:R:F88	R:R:Y104	47.7968	4.13	No	No	0	5	6
8	R:R:T84	R:R:Y104	50.1797	3.75	No	No	0	5	6
9	R:R:T84	R:R:V83	28.7398	3.17	No	No	0	5	4
10	R:R:F79	R:R:V83	27.3404	7.87	No	No	0	7	4
11	R:R:F79	R:R:V47	24.5036	2.62	No	No	0	7	6
12	R:R:F48	R:R:V47	23.0663	2.62	No	No	0	4	6
13	R:R:F111	R:R:T84	71.2413	15.56	No	No	0	5	5
14	R:R:F111	R:R:F115	72.0734	23.58	No	Yes	0	5	7
15	R:R:F115	R:R:W157	81.2961	3.01	Yes	Yes	0	7	9
16	R:R:H122	R:R:W157	82.3804	4.23	Yes	Yes	4	8	9
17	R:R:H122	R:R:S73	93.3241	5.58	Yes	No	0	8	9
18	R:R:I153	R:R:S73	92.7693	12.39	No	No	0	8	9
19	R:R:G150	R:R:I153	92.202	3.53	No	No	0	4	8
20	R:R:G150	R:R:S149	91.622	3.71	No	No	0	4	7
21	R:R:F69	R:R:S149	89.1761	5.28	No	No	0	5	7
22	R:R:F69	R:R:V146	87.8774	5.24	No	No	0	5	3
23	R:R:P66	R:R:V146	87.2092	3.53	No	No	0	6	3
24	R:R:F144	R:R:P66	86.5284	4.33	No	No	0	6	6
25	R:R:D129	R:R:F144	57.9399	13.14	Yes	No	2	9	6
26	R:R:D129	R:R:T67	23.5264	8.67	Yes	No	2	9	8
27	R:R:T65	R:R:T67	44.9411	3.14	No	No	0	8	8
28	R:R:N68	R:R:T65	42.6968	5.85	No	No	0	9	8
29	R:R:F318	R:R:N68	36.0777	7.25	No	No	0	9	9
30	R:R:F318	R:R:I57	51.2703	5.02	No	Yes	0	9	7
31	R:R:I57	R:R:V53	29.4585	3.07	Yes	No	0	7	9
32	R:R:A75	R:R:V53	22.1837	3.39	No	No	0	9	9
33	R:R:A75	R:R:N50	18.5904	3.13	No	No	0	9	9
34	R:R:D78	R:R:N50	11.1706	14.81	Yes	No	3	9	9
35	R:R:F144	R:R:Y140	27.8888	7.22	No	Yes	2	6	7
36	R:R:T67	R:R:Y140	23.7219	3.75	No	Yes	2	8	7
37	R:R:D129	R:R:R130	34.2558	4.76	Yes	No	0	9	9
38	R:R:R130	R:R:Y315	33.203	3.09	No	No	0	9	8
39	R:R:W317	R:R:Y315	22.6943	15.43	No	No	0	6	8
40	R:R:F318	R:R:W317	19.2523	8.02	No	No	0	9	6
41	R:R:I57	R:R:L58	11.0509	1.43	Yes	No	0	7	4
42	R:R:F48	R:R:G49	20.1538	1.51	No	No	0	4	8
43	R:R:G49	R:R:L52	18.6787	1.71	No	No	0	8	7
44	R:R:I322	R:R:L52	17.1909	2.85	Yes	No	0	7	7
45	R:R:A56	R:R:I322	11.1139	1.62	No	Yes	0	7	7
46	R:R:H122	R:R:L74	100	5.14	Yes	No	0	8	9
47	R:R:L74	R:R:N307	99.2561	6.87	No	No	0	9	9
48	R:R:N303	R:R:N307	95.7763	6.81	No	No	0	9	9
49	R:R:N303	R:R:W271	94.2634	7.91	No	Yes	0	9	8
50	R:R:F117	R:R:W271	26.7667	6.01	No	Yes	0	5	8
51	R:R:F117	R:R:Y163	19.5991	4.13	No	Yes	0	5	5
52	R:R:I167	R:R:Y163	15.388	18.13	No	Yes	0	5	5
53	R:R:F115	R:R:S114	14.102	2.64	Yes	Yes	0	7	5
54	R:R:F267	R:R:W271	55.3678	3.01	Yes	Yes	1	9	8
55	R:R:L123	R:R:N307	11.1139	4.12	No	No	0	8	9
56	R:R:F267	R:R:M213	51.3333	7.46	Yes	No	0	9	8
57	R:R:M213	R:R:M264	50.1671	4.33	No	Yes	0	8	8
58	R:R:M264	R:R:Y217	46.5927	4.79	Yes	No	0	8	9
59	R:R:S127	R:R:Y217	18.603	3.82	No	No	0	8	9
60	R:R:L216	R:R:S127	17.1216	4.5	No	No	0	6	8
61	R:R:L216	R:R:Y131	14.1209	7.03	No	No	0	6	8
62	R:R:L260	R:R:Y217	29.7926	9.38	No	No	0	7	9
63	R:R:I220	R:R:L260	28.3994	4.28	No	No	0	9	7
64	R:R:I220	R:R:V134	26.9999	9.22	No	No	0	9	8
65	R:R:V134	R:R:V223	25.6887	3.21	No	No	0	8	5
66	R:R:D277	R:R:D281	17.1909	7.98	No	Yes	0	5	3
67	R:R:D277	R:R:L296	18.6787	5.43	No	No	0	5	5
68	R:R:L296	R:R:Y274	20.1538	3.52	No	No	0	5	6
69	R:R:V300	R:R:Y274	21.6163	3.79	No	No	0	7	6
70	R:R:V300	R:R:W271	23.0663	7.36	No	Yes	0	7	8
71	R:R:V223	R:R:Y226	24.2766	8.83	No	Yes	0	5	5
72	R:R:R229	R:R:Y226	19.9458	3.09	No	Yes	0	4	5
73	R:R:K225	R:R:R229	18.477	3.71	No	No	0	5	4
74	R:R:E253	R:R:K225	16.9892	4.05	No	No	0	7	5
75	R:R:E232	R:R:V249	12.589	1.43	Yes	No	0	4	4
76	R:R:E253	R:R:V249	15.6213	1.43	No	No	0	7	4
77	R:R:F314	R:R:Y315	12.0469	3.09	No	No	0	7	8
78	R:R:F314	R:R:T259	10.7294	7.78	No	No	0	7	8
79	R:R:D112	R:R:V85	10.0927	10.22	No	No	6	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8IW1_nogp

PDB Summary
PDB	8IW1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	244
Number of Links	250
Number of Hubs	25
Number of Links mediated by Hubs	101
Number of Communities	8
Number of Nodes involved in Communities	27
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	31006
Length Of Smallest Path	3
Average Path Length	19.1666
Length of Longest Path	41
Minimum Path Strength	1.16
Average Path Strength	6.03233
Maximum Path Strength	19.57
Minimum Path Correlation	0.7
Average Path Correlation	0.930639
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	40.0992
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	24.3023
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD04
Sequence	>8IW1_nogp_Chain_R P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F K Q L H T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S C W Y F G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D P L T Y P T K F T V S V S G L C I A L S W F F S V T Y S F S I F Y T G C Q A P L N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G S Y K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M N F I T P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W F R K A I K L I V S G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ITF	A	Orphan	Orphan	TAA9	Mus musculus	DMCHA	-	chim(NtGi1-Gs)/β1/γ2	3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8ITF (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	DMCHA	-		3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1	A	Orphan	Orphan	TAA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	-	-		3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4	A	Orphan	Orphan	TAA9	Mus musculus	Spermidine	-	chim(NtGi1-Gs)/β1/γ2	3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	Spermidine	-		3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7	A	Orphan	Orphan	TAA9	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	2-Phenylethylamine	-		2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9	A	Orphan	Orphan	TAA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	-	-		3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWE	A	Orphan	Orphan	TAA9	Mus musculus	Spermidine	-	-	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWM	A	Orphan	Orphan	TAA9	Mus musculus	2-Phenylethylamine	-	-	3.17	2023-05-31	doi.org/10.1038/s41586-023-06106-4

there is no ligand in network 8IW1_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.