psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	11.67	Yes	No	1	0	6
2	L:L:?1	R:R:T113	7.92	Yes	No	1	0	4
3	L:L:?1	R:R:F117	5.24	Yes	No	0	0	5
4	L:L:?1	R:R:Y274	12.6	Yes	No	0	0	6
5	L:L:?1	R:R:V297	4.81	Yes	No	1	0	6
6	L:L:?1	R:R:V300	3.2	Yes	No	0	0	7
7	L:L:?1	R:R:Y301	11.34	Yes	Yes	1	0	8
8	R:R:C186	R:R:C22	7.28	No	No	0	3	8
9	R:R:C22	R:R:V187	3.42	No	No	0	8	3
10	R:R:P29	R:R:Y27	11.13	No	No	0	3	1
11	R:R:S96	R:R:Y27	5.09	No	No	0	3	1
12	R:R:P31	R:R:W30	4.05	No	No	0	3	1
13	R:R:L35	R:R:Y36	3.52	No	Yes	0	5	5
14	R:R:L35	R:R:L39	4.15	No	Yes	0	5	7
15	R:R:V94	R:R:Y36	6.31	No	Yes	4	6	5
16	R:R:E95	R:R:Y36	4.49	No	Yes	4	5	5
17	R:R:L39	R:R:V38	2.98	Yes	No	0	7	5
18	R:R:L39	R:R:T90	2.95	Yes	No	0	7	6
19	R:R:L39	R:R:W298	4.56	Yes	Yes	0	7	5
20	R:R:G42	R:R:Y302	4.35	No	No	0	6	6
21	R:R:A43	R:R:M86	4.83	No	Yes	0	6	7
22	R:R:A46	R:R:M86	3.22	No	Yes	0	7	7
23	R:R:A75	R:R:N50	4.69	No	No	0	9	9
24	R:R:D78	R:R:N50	4.04	Yes	No	0	9	9
25	R:R:N50	R:R:P308	9.77	No	No	0	9	9
26	R:R:I54	R:R:L51	2.85	No	No	0	8	4
27	R:R:F79	R:R:L51	3.65	No	No	0	7	4
28	R:R:I322	R:R:L52	4.28	No	No	0	7	7
29	R:R:I325	R:R:L52	2.85	Yes	No	0	6	7
30	R:R:A312	R:R:V53	3.39	No	No	0	7	9
31	R:R:A72	R:R:I57	4.87	No	No	0	6	7
32	R:R:F318	R:R:I57	5.02	Yes	No	0	9	7
33	R:R:F60	R:R:H59	10.18	Yes	No	6	5	6
34	R:R:H59	R:R:V330	5.54	No	No	0	6	6
35	R:R:D334	R:R:H59	3.78	No	No	6	4	6
36	R:R:F60	R:R:L63	3.65	Yes	No	0	5	8
37	R:R:A321	R:R:F60	2.77	No	Yes	0	7	5
38	R:R:D334	R:R:F60	3.58	No	Yes	6	4	5
39	R:R:D334	R:R:K61	2.77	No	No	0	4	6
40	R:R:Q62	R:R:S336	7.22	No	No	0	6	5
41	R:R:Q62	R:R:T337	4.25	No	No	0	6	4
42	R:R:L63	R:R:N68	5.49	No	No	0	8	9
43	R:R:P66	R:R:T65	3.5	Yes	No	0	6	8
44	R:R:N68	R:R:T65	4.39	No	No	0	9	8
45	R:R:F144	R:R:P66	2.89	Yes	Yes	2	6	6
46	R:R:P66	R:R:V146	3.53	Yes	No	0	6	3
47	R:R:P66	R:R:S149	5.34	Yes	No	2	6	7
48	R:R:D129	R:R:T67	8.67	No	No	0	9	8
49	R:R:F318	R:R:N68	4.83	Yes	No	0	9	9
50	R:R:C125	R:R:L70	3.17	No	No	0	6	8
51	R:R:H122	R:R:S73	6.97	No	No	0	8	9
52	R:R:I153	R:R:S73	7.74	No	No	0	8	9
53	R:R:H122	R:R:L74	5.14	No	No	0	8	9
54	R:R:L74	R:R:N307	6.87	No	Yes	0	9	9
55	R:R:D78	R:R:S119	5.89	Yes	No	5	9	9
56	R:R:D78	R:R:S304	8.83	Yes	No	0	9	9
57	R:R:D78	R:R:N307	8.08	Yes	Yes	5	9	9
58	R:R:F115	R:R:L80	10.96	No	No	0	7	7
59	R:R:V81	R:R:V85	4.81	No	Yes	0	7	7
60	R:R:S304	R:R:V81	3.23	No	No	0	9	7
61	R:R:G82	R:R:M86	5.24	No	Yes	0	7	7
62	R:R:S89	R:R:V85	3.23	No	Yes	1	6	7
63	R:R:H108	R:R:V85	8.3	Yes	Yes	1	5	7
64	R:R:D112	R:R:V85	7.3	No	Yes	1	6	7
65	R:R:F100	R:R:F88	6.43	Yes	No	0	6	5
66	R:R:F88	R:R:Y104	5.16	No	Yes	0	5	6
67	R:R:R92	R:R:S89	3.95	No	No	0	5	6
68	R:R:H108	R:R:S89	8.37	Yes	No	1	5	6
69	R:R:F100	R:R:V91	5.24	Yes	No	0	6	4
70	R:R:Q191	R:R:R92	4.67	No	No	0	1	5
71	R:R:S93	R:R:W298	6.18	No	Yes	0	4	5
72	R:R:E95	R:R:V94	5.7	No	No	4	5	6
73	R:R:C97	R:R:Y99	8.06	No	No	0	4	2
74	R:R:F100	R:R:W98	6.01	Yes	Yes	0	6	8
75	R:R:W98	R:R:Y104	2.89	Yes	Yes	1	8	6
76	R:R:H108	R:R:W98	9.52	Yes	Yes	1	5	8
77	R:R:G189	R:R:W98	2.81	No	Yes	0	3	8
78	R:R:E102	R:R:V187	7.13	No	No	0	3	3
79	R:R:H108	R:R:Y104	7.62	Yes	Yes	1	5	6
80	R:R:C105	R:R:C190	3.64	No	No	0	9	9
81	R:R:F168	R:R:T109	5.19	Yes	No	0	5	5
82	R:R:C110	R:R:Y169	4.03	No	No	0	6	5
83	R:R:D112	R:R:Y301	13.79	No	Yes	1	6	8
84	R:R:T113	R:R:Y163	7.49	No	No	1	4	5
85	R:R:F168	R:R:T113	11.67	Yes	No	1	5	4
86	R:R:S114	R:R:S164	6.52	No	No	0	5	7
87	R:R:F115	R:R:W157	4.01	No	No	0	7	9
88	R:R:F117	R:R:L205	4.87	No	No	0	5	4
89	R:R:F117	R:R:W271	4.01	No	Yes	0	5	8
90	R:R:A118	R:R:W157	6.48	No	No	0	7	9
91	R:R:A118	R:R:S160	3.42	No	No	0	7	8
92	R:R:N307	R:R:S119	4.47	Yes	No	5	9	9
93	R:R:F121	R:R:S156	3.96	No	No	0	5	7
94	R:R:F121	R:R:P209	2.89	No	No	0	5	9
95	R:R:H122	R:R:S156	8.37	No	No	0	8	7
96	R:R:L123	R:R:Y311	7.03	No	No	0	8	9
97	R:R:C124	R:R:P209	3.77	No	No	0	7	9
98	R:R:C124	R:R:V212	3.42	No	No	0	7	6
99	R:R:C125	R:R:C152	5.46	No	No	0	6	6
100	R:R:I126	R:R:Y311	4.84	No	No	0	9	9
101	R:R:M213	R:R:S127	4.6	Yes	No	3	8	8
102	R:R:S127	R:R:Y217	5.09	No	Yes	3	8	9
103	R:R:I128	R:R:L216	2.85	No	No	0	7	6
104	R:R:D129	R:R:Y140	5.75	No	Yes	2	9	7
105	R:R:D129	R:R:F144	19.11	No	Yes	2	9	6
106	R:R:R130	R:R:Y217	5.14	No	Yes	0	9	9
107	R:R:R130	R:R:Y315	3.09	No	No	0	9	8
108	R:R:T135	R:R:Y131	14.98	No	No	0	6	8
109	R:R:L216	R:R:Y131	12.89	No	No	0	6	8
110	R:R:R219	R:R:Y131	5.14	No	No	0	4	8
111	R:R:A133	R:R:Y140	5.34	No	Yes	0	8	7
112	R:R:D136	R:R:P137	3.22	Yes	No	0	6	8
113	R:R:D136	R:R:T139	10.12	Yes	No	7	6	5
114	R:R:D136	R:R:K143	5.53	Yes	Yes	7	6	4
115	R:R:K143	R:R:T139	3	Yes	No	7	4	5
116	R:R:P141	R:R:Y140	2.78	No	Yes	0	4	7
117	R:R:F144	R:R:Y140	5.16	Yes	Yes	2	6	7
118	R:R:K143	R:R:T142	3	Yes	No	0	4	4
119	R:R:F144	R:R:S149	3.96	Yes	No	2	6	7
120	R:R:F159	R:R:L155	6.09	No	No	0	4	2
121	R:R:F158	R:R:T162	5.19	No	No	0	4	4
122	R:R:I167	R:R:Y163	3.63	Yes	No	1	5	5
123	R:R:F168	R:R:Y163	3.09	Yes	No	1	5	5
124	R:R:F165	R:R:Y169	3.09	No	No	0	4	5
125	R:R:I167	R:R:S166	3.1	Yes	No	0	5	6
126	R:R:F168	R:R:I167	7.54	Yes	Yes	1	5	5
127	R:R:F168	R:R:L194	3.65	Yes	No	0	5	4
128	R:R:E174	R:R:N173	11.83	No	No	0	4	4
129	R:R:E175	R:R:N195	5.26	No	No	0	2	4
130	R:R:Q191	R:R:Y293	9.02	No	No	0	1	4
131	R:R:L194	R:R:V199	5.96	No	Yes	0	4	5
132	R:R:C202	R:R:L194	3.17	No	No	0	5	4
133	R:R:N195	R:R:W198	10.17	No	No	0	4	6
134	R:R:Q196	R:R:Y283	15.78	No	No	0	2	4
135	R:R:L200	R:R:V199	2.98	No	Yes	8	5	5
136	R:R:A282	R:R:V199	5.09	No	Yes	0	4	5
137	R:R:V199	R:R:Y283	5.05	Yes	No	8	5	4
138	R:R:L200	R:R:Y283	5.86	No	No	8	5	4
139	R:R:L201	R:R:L205	2.77	No	No	0	5	4
140	R:R:F206	R:R:T210	5.19	Yes	No	0	8	6
141	R:R:F206	R:R:W271	8.02	Yes	Yes	0	8	8
142	R:R:F206	R:R:I275	7.54	Yes	No	0	8	7
143	R:R:F267	R:R:T210	7.78	Yes	No	0	9	6
144	R:R:L268	R:R:T210	2.95	No	No	0	6	6
145	R:R:L216	R:R:V212	2.98	No	No	0	6	6
146	R:R:M213	R:R:Y217	3.59	Yes	Yes	3	8	9
147	R:R:M213	R:R:M264	5.78	Yes	Yes	3	8	8
148	R:R:F267	R:R:M213	6.22	Yes	Yes	0	9	8
149	R:R:F215	R:R:R219	3.21	No	No	0	5	4
150	R:R:I220	R:R:Y217	3.63	No	Yes	0	9	9
151	R:R:L260	R:R:Y217	8.21	No	Yes	0	7	9
152	R:R:M264	R:R:Y217	3.59	Yes	Yes	3	8	9
153	R:R:A256	R:R:F221	2.77	No	No	0	8	5
154	R:R:K225	R:R:R229	3.71	No	No	0	5	4
155	R:R:E253	R:R:K225	13.5	No	No	0	7	5
156	R:R:K230	R:R:Y226	3.58	No	No	0	3	5
157	R:R:A228	R:R:R252	2.77	No	No	0	4	6
158	R:R:R229	R:R:S244	6.59	No	No	0	4	3
159	R:R:E232	R:R:R248	4.65	No	No	0	4	3
160	R:R:E232	R:R:V249	2.85	No	No	0	4	4
161	R:R:E247	R:R:Y245	26.93	No	No	0	4	3
162	R:R:K251	R:R:R248	3.71	No	No	0	5	3
163	R:R:R248	R:R:R252	5.33	No	No	0	3	6
164	R:R:L260	R:R:T259	2.95	No	No	0	7	8
165	R:R:F267	R:R:W271	4.01	Yes	Yes	0	9	8
166	R:R:S270	R:R:W271	4.94	No	Yes	0	8	8
167	R:R:N303	R:R:S270	7.45	No	No	0	9	8
168	R:R:V300	R:R:W271	3.68	No	Yes	0	7	8
169	R:R:Y274	R:R:Y293	4.96	No	No	0	6	4
170	R:R:D277	R:R:T288	8.67	No	No	0	5	6
171	R:R:D277	R:R:L296	4.07	No	No	0	5	5
172	R:R:D281	R:R:F286	22.69	No	No	0	3	2
173	R:R:D281	R:R:T288	4.34	No	No	0	3	6
174	R:R:P289	R:R:T288	3.5	No	No	0	4	6
175	R:R:P289	R:R:V292	3.53	No	No	0	4	5
176	R:R:V297	R:R:Y293	5.05	No	No	0	6	4
177	R:R:E294	R:R:I295	9.56	No	No	0	4	5
178	R:R:V297	R:R:Y301	6.31	No	Yes	1	6	8
179	R:R:W298	R:R:Y301	6.75	Yes	Yes	0	5	8
180	R:R:M306	R:R:N303	2.8	No	No	0	5	9
181	R:R:N303	R:R:N307	5.45	No	Yes	0	9	9
182	R:R:F313	R:R:L309	3.65	No	No	0	5	6
183	R:R:I310	R:R:Y311	7.25	No	No	0	8	9
184	R:R:A312	R:R:F318	2.77	No	Yes	0	7	9
185	R:R:F313	R:R:I322	5.02	No	No	0	5	7
186	R:R:W317	R:R:Y315	13.5	No	No	0	6	8
187	R:R:P316	R:R:W317	4.05	No	No	0	4	6
188	R:R:P316	R:R:R319	4.32	No	No	0	4	8
189	R:R:F318	R:R:W317	8.02	Yes	No	0	9	6
190	R:R:K320	R:R:T338	4.5	No	No	0	5	6
191	R:R:K329	R:R:L324	5.64	No	No	0	6	4
192	R:R:I325	R:R:V330	3.07	Yes	No	0	6	6
193	R:R:K329	R:R:S327	3.06	No	No	0	6	6
194	R:R:F331	R:R:G328	3.01	No	No	0	5	4
195	R:R:N339	R:R:T337	2.92	No	No	0	5	4
196	R:R:A33	R:R:Y36	2.67	No	Yes	0	5	5
197	R:R:F121	R:R:S160	2.64	No	No	0	5	8
198	R:R:F79	R:R:V47	2.62	No	No	0	7	6
199	R:R:F144	R:R:V148	2.62	Yes	No	0	6	6
200	R:R:F165	R:R:V161	2.62	No	No	0	4	3
201	R:R:R229	R:R:V249	2.62	No	No	0	4	4
202	R:R:F60	R:R:T337	2.59	Yes	No	0	5	4
203	R:R:A77	R:R:W157	2.59	No	No	0	8	9
204	R:R:F111	R:R:T84	2.59	No	No	0	5	5
205	R:R:F203	R:R:I275	2.51	No	No	0	6	7
206	R:R:K258	R:R:R254	2.48	No	No	0	7	4
207	R:R:F79	R:R:L80	2.44	No	No	0	7	7
208	R:R:F267	R:R:L120	2.44	Yes	No	0	9	7
209	R:R:F267	R:R:L123	2.44	Yes	No	0	9	8
210	R:R:F203	R:R:L204	2.44	No	No	0	6	4
211	R:R:F206	R:R:L272	2.44	Yes	No	0	8	6
212	R:R:F207	R:R:L208	2.44	No	No	0	4	5
213	R:R:I23	R:R:Y99	2.42	No	No	0	2	2
214	R:R:I132	R:R:Y140	2.42	No	Yes	0	5	7
215	R:R:F286	R:R:N285	2.42	No	No	0	2	1
216	R:R:K106	R:R:Y169	2.39	No	No	0	6	5
217	R:R:I167	R:R:W198	2.35	Yes	No	0	5	6
218	R:R:M86	R:R:W298	2.33	Yes	Yes	0	7	5
219	R:R:E253	R:R:F221	2.33	No	No	0	7	5
220	R:R:N197	R:R:W198	2.26	No	No	0	4	6
221	R:R:E95	R:R:Y27	2.24	No	No	0	5	1
222	R:R:G37	R:R:G40	2.11	No	No	0	4	4
223	R:R:G188	R:R:G189	2.11	No	No	0	4	3
224	R:R:F107	R:R:Y104	2.06	No	Yes	0	5	6
225	R:R:A43	R:R:G40	1.95	No	No	0	6	4
226	R:R:A28	R:R:P29	1.87	No	No	0	4	3
227	R:R:A192	R:R:P193	1.87	No	No	0	4	3
228	R:R:G328	R:R:S327	1.86	No	No	0	4	6
229	R:R:A192	R:R:C190	1.81	No	No	0	4	9
230	R:R:A305	R:R:A46	1.79	No	No	0	7	7
231	R:R:G261	R:R:M264	1.75	No	Yes	0	5	8
232	R:R:C299	R:R:S270	1.72	No	No	0	7	8
233	R:R:G42	R:R:L45	1.71	No	No	0	6	4
234	R:R:G49	R:R:L45	1.71	No	No	0	8	4
235	R:R:C152	R:R:V148	1.71	No	No	0	6	6
236	R:R:G171	R:R:N173	1.7	No	No	0	1	4
237	R:R:M86	R:R:P87	1.68	Yes	No	0	7	8
238	R:R:A172	R:R:T170	1.68	No	No	0	6	5
239	R:R:C76	R:R:I54	1.64	No	No	0	7	8
240	R:R:L208	R:R:P209	1.64	No	No	0	5	9
241	R:R:L272	R:R:P273	1.64	No	No	0	6	9
242	R:R:L296	R:R:P273	1.64	No	No	0	5	9
243	R:R:S114	R:R:S160	1.63	No	No	0	5	8
244	R:R:A56	R:R:I322	1.62	No	No	0	7	7
245	R:R:A56	R:R:I325	1.62	No	Yes	0	7	6
246	R:R:S164	R:R:V161	1.62	No	No	0	7	3
247	R:R:A263	R:R:I310	1.62	No	No	0	8	8
248	R:R:A266	R:R:I310	1.62	No	No	0	7	8
249	R:R:V134	R:R:V223	1.6	No	No	0	8	5
250	R:R:V211	R:R:V212	1.6	No	No	0	3	6
251	R:R:T84	R:R:V83	1.59	No	No	0	5	4
252	R:R:T84	R:R:V85	1.59	No	Yes	0	5	7
253	R:R:T145	R:R:V148	1.59	No	No	0	7	6
254	R:R:I57	R:R:V71	1.54	No	No	0	7	8
255	R:R:I126	R:R:V71	1.54	No	No	0	9	8
256	R:R:I276	R:R:V279	1.54	No	No	0	6	6
257	R:R:M264	R:R:V214	1.52	Yes	No	0	8	5
258	R:R:K246	R:R:V249	1.52	No	No	0	5	4
259	R:R:F48	R:R:G49	1.51	No	No	0	4	8
260	R:R:F100	R:R:G101	1.51	Yes	No	0	6	8
261	R:R:F221	R:R:G218	1.51	No	No	0	5	3
262	R:R:L324	R:R:S335	1.5	No	No	0	4	7
263	R:R:I54	R:R:I55	1.47	No	No	0	8	4
264	R:R:I325	R:R:I55	1.47	Yes	No	0	6	4
265	R:R:I276	R:R:I280	1.47	No	No	0	6	4
266	R:R:I132	R:R:K143	1.45	No	Yes	0	5	4
267	R:R:D136	R:R:T135	1.45	Yes	No	0	6	6
268	R:R:E294	R:R:S93	1.44	No	No	0	4	4
269	R:R:F286	R:R:P193	1.44	No	No	0	2	3
270	R:R:I167	R:R:N173	1.42	Yes	No	0	5	4
271	R:R:K225	R:R:L222	1.41	No	No	0	5	3
272	R:R:K320	R:R:L324	1.41	No	No	0	5	4
273	R:R:L151	R:R:L155	1.38	No	No	0	3	2
274	R:R:F60	R:R:S335	1.32	Yes	No	0	5	7
275	R:R:F48	R:R:V47	1.31	No	No	0	4	6
276	R:R:H64	R:R:K61	1.31	No	No	0	7	6
277	R:R:F69	R:R:V146	1.31	No	No	0	5	3
278	R:R:F165	R:R:T162	1.3	No	No	0	4	4
279	R:R:V292	R:R:Y291	1.26	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.11143	7	1	0
2	R:R:Y36	4.2475	4	4	5
3	R:R:L39	3.66	4	0	7
4	R:R:F60	4.015	6	6	5
5	R:R:P66	3.815	4	2	6
6	R:R:D78	6.71	4	5	9
7	R:R:V85	5.046	5	1	7
8	R:R:M86	3.46	5	0	7
9	R:R:W98	5.3075	4	1	8
10	R:R:F100	4.7975	4	0	6
11	R:R:Y104	4.4325	4	1	6
12	R:R:H108	8.4525	4	1	5
13	R:R:D136	5.08	4	7	6
14	R:R:Y140	4.29	5	2	7
15	R:R:K143	3.245	4	7	4
16	R:R:F144	6.748	5	2	6
17	R:R:I167	3.608	5	1	5
18	R:R:F168	6.228	5	1	5
19	R:R:V199	4.77	4	8	5
20	R:R:F206	5.7975	4	0	8
21	R:R:M213	5.0475	4	3	8
22	R:R:Y217	4.875	6	3	9
23	R:R:M264	3.16	4	3	8
24	R:R:F267	4.578	5	0	9
25	R:R:W271	4.932	5	0	8
26	R:R:W298	4.955	4	0	5
27	R:R:Y301	9.5475	4	1	8
28	R:R:N307	6.2175	4	5	9
29	R:R:F318	5.16	4	0	9
30	R:R:I325	2.2525	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y301	41.7207	11.34	Yes	Yes	1	0	8
2	R:R:W298	R:R:Y301	46.663	6.75	Yes	Yes	0	5	8
3	R:R:L39	R:R:W298	23.7928	4.56	Yes	Yes	0	7	5
4	R:R:L35	R:R:L39	17.8839	4.15	No	Yes	0	5	7
5	R:R:L35	R:R:Y36	15.8997	3.52	No	Yes	0	5	5
6	L:L:?1	R:R:F117	58.5612	5.24	Yes	No	0	0	5
7	R:R:F117	R:R:W271	60.0439	4.01	No	Yes	0	5	8
8	R:R:S270	R:R:W271	36.2585	4.94	No	Yes	0	8	8
9	R:R:N303	R:R:S270	34.384	7.45	No	No	0	9	8
10	R:R:N303	R:R:N307	32.9636	5.45	No	Yes	0	9	9
11	R:R:L74	R:R:N307	38.1732	6.87	No	Yes	0	9	9
12	R:R:H122	R:R:L74	37.4044	5.14	No	No	0	8	9
13	R:R:H122	R:R:S156	35.4494	8.37	No	No	0	8	7
14	R:R:F121	R:R:S156	34.9002	3.96	No	No	0	5	7
15	R:R:F121	R:R:S160	24.331	2.64	No	No	0	5	8
16	R:R:A118	R:R:S160	16.2402	3.42	No	No	0	7	8
17	R:R:A118	R:R:W157	15.4311	6.48	No	No	0	7	9
18	R:R:F115	R:R:W157	13.8935	4.01	No	No	0	7	9
19	R:R:F115	R:R:L80	13.1832	10.96	No	No	0	7	7
20	R:R:F79	R:R:L80	12.5316	2.44	No	No	0	7	7
21	L:L:?1	R:R:V300	57.9608	3.2	Yes	No	0	0	7
22	R:R:V300	R:R:W271	58.4551	3.68	No	Yes	0	7	8
23	R:R:M86	R:R:W298	16.134	2.33	Yes	Yes	0	7	5
24	L:L:?1	R:R:D112	22.8043	11.67	Yes	No	1	0	6
25	R:R:D112	R:R:V85	28.2555	7.3	No	Yes	1	6	7
26	R:R:V81	R:R:V85	10.767	4.81	No	Yes	0	7	7
27	R:R:D78	R:R:S304	10.1959	8.83	Yes	No	0	9	9
28	R:R:F267	R:R:W271	100	4.01	Yes	Yes	0	9	8
29	R:R:F267	R:R:M213	56.566	6.22	Yes	Yes	0	9	8
30	R:R:M213	R:R:Y217	52.0776	3.59	Yes	Yes	3	8	9
31	R:R:R130	R:R:Y217	50.5473	5.14	No	Yes	0	9	9
32	R:R:R130	R:R:Y315	49.9579	3.09	No	No	0	9	8
33	R:R:W317	R:R:Y315	49.4307	13.5	No	No	0	6	8
34	R:R:F318	R:R:W317	47.6405	8.02	Yes	No	0	9	6
35	R:R:F318	R:R:N68	89.2111	4.83	Yes	No	0	9	9
36	R:R:L63	R:R:N68	58.2976	5.49	No	No	0	8	9
37	R:R:F60	R:R:L63	56.6319	3.65	Yes	No	0	5	8
38	R:R:F60	R:R:H59	27.4538	10.18	Yes	No	6	5	6
39	R:R:H59	R:R:V330	26.2237	5.54	No	No	0	6	6
40	R:R:I325	R:R:V330	24.7227	3.07	Yes	No	0	6	6
41	R:R:I325	R:R:I55	10.2361	1.47	Yes	No	0	6	4
42	R:R:F267	R:R:L123	52.0776	2.44	Yes	No	0	9	8
43	R:R:L123	R:R:Y311	51.3637	7.03	No	No	0	8	9
44	R:R:I126	R:R:Y311	48.6912	4.84	No	No	0	9	9
45	R:R:I126	R:R:V71	48.0432	1.54	No	No	0	9	8
46	R:R:I57	R:R:V71	47.4135	1.54	No	No	0	7	8
47	R:R:F318	R:R:I57	46.3555	5.02	Yes	No	0	9	7
48	R:R:N68	R:R:T65	37.6167	4.39	No	No	0	9	8
49	R:R:P66	R:R:T65	35.8777	3.5	Yes	No	0	6	8
50	R:R:F144	R:R:P66	28.834	2.89	Yes	Yes	2	6	6
51	R:R:F144	R:R:V148	10.1922	2.62	Yes	No	0	6	6
52	R:R:H108	R:R:V85	15.5043	8.3	Yes	Yes	1	5	7
53	R:R:F206	R:R:W271	26.641	8.02	Yes	Yes	0	8	8
54	R:R:F206	R:R:L272	27.5636	2.44	Yes	No	0	8	6
55	R:R:L272	R:R:P273	25.7697	1.64	No	No	0	6	9
56	R:R:L296	R:R:P273	23.9685	1.64	No	No	0	5	9
57	R:R:D277	R:R:L296	22.16	4.07	No	No	0	5	5
58	R:R:D277	R:R:T288	20.3441	8.67	No	No	0	5	6
59	R:R:D281	R:R:T288	13.0075	4.34	No	No	0	3	6
60	R:R:D281	R:R:F286	11.155	22.69	No	No	0	3	2
61	L:L:?1	R:R:T113	51.8067	7.92	Yes	No	1	0	4
62	R:R:F168	R:R:T113	32.2204	11.67	Yes	No	1	5	4
63	R:R:S114	R:R:S160	10.5254	1.63	No	No	0	5	8
64	R:R:T113	R:R:Y163	17.8986	7.49	No	No	1	4	5
65	R:R:F121	R:R:P209	15.6983	2.89	No	No	0	5	9
66	R:R:C124	R:R:P209	12.9526	3.77	No	No	0	7	9
67	R:R:C124	R:R:V212	12.1728	3.42	No	No	0	7	6
68	R:R:L216	R:R:V212	10.6571	2.98	No	No	0	6	6
69	R:R:F144	R:R:Y140	15.0247	5.16	Yes	Yes	2	6	7
70	R:R:I132	R:R:Y140	10.3057	2.42	No	Yes	0	5	7
71	R:R:I167	R:R:Y163	16.1413	3.63	Yes	No	1	5	5
72	R:R:F168	R:R:I167	16.4049	7.54	Yes	Yes	1	5	5
73	R:R:F168	R:R:L194	12.8354	3.65	Yes	No	0	5	4
74	R:R:I167	R:R:N173	10.9134	1.42	Yes	No	0	5	4
75	R:R:I167	R:R:W198	14.5378	2.35	Yes	No	0	5	6
76	R:R:F206	R:R:T210	11.2283	5.19	Yes	No	0	8	6
77	R:R:F267	R:R:T210	12.1362	7.78	Yes	No	0	9	6
78	R:R:F60	R:R:S335	16.4269	1.32	Yes	No	0	5	7
79	R:R:L324	R:R:S335	14.3987	1.5	No	No	0	4	7
80	R:R:D78	R:R:N307	11.5797	8.08	Yes	Yes	5	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D112	11.67	1	Yes	No	0	6	0	1
L:L:?1	R:R:T113	7.92	1	Yes	No	0	4	0	1
L:L:?1	R:R:F117	5.24	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y274	12.6	1	Yes	No	0	6	0	1
L:L:?1	R:R:V297	4.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:V300	3.2	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y301	11.34	1	Yes	Yes	0	8	0	1
R:R:D112	R:R:V85	7.3	1	No	Yes	6	7	1	2
R:R:D112	R:R:Y301	13.79	1	No	Yes	6	8	1	1
R:R:T113	R:R:Y163	7.49	1	No	No	4	5	1	2
R:R:F168	R:R:T113	11.67	1	Yes	No	5	4	2	1
R:R:F117	R:R:L205	4.87	0	No	No	5	4	1	2
R:R:F117	R:R:W271	4.01	0	No	Yes	5	8	1	2
R:R:F168	R:R:Y163	3.09	1	Yes	No	5	5	2	2
R:R:V300	R:R:W271	3.68	0	No	Yes	7	8	1	2
R:R:Y274	R:R:Y293	4.96	0	No	No	6	4	1	2
R:R:V297	R:R:Y293	5.05	1	No	No	6	4	1	2
R:R:V297	R:R:Y301	6.31	1	No	Yes	6	8	1	1
R:R:W298	R:R:Y301	6.75	0	Yes	Yes	5	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ITF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	266
Number of Links	279
Number of Hubs	30
Number of Links mediated by Hubs	115
Number of Communities	8
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	55156
Length Of Smallest Path	3
Average Path Length	15.8613
Length of Longest Path	32
Minimum Path Strength	1.41
Average Path Strength	5.16471
Maximum Path Strength	13.935
Minimum Path Correlation	0.7
Average Path Correlation	0.933894
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.2907
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.8601
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8IA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8IA
Name	~{N},~{N}-dimethylcyclohexanamine
Synonyms
Identifier
Formula	C8 H17 N
Molecular Weight	127.227
SMILES
PubChem	7415
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD04
Sequence	>8ITF_nogp_Chain_R C I K S S Y A P W P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F K Q L H T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S C W Y F G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D P L T Y P T K F T V S V S G L C I A L S W F F S V T Y S F S I F Y T G A N E E T C V G G C Q A P L N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G S Y K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M N F I T P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W F R K A I K L I V S G K V F R A D S S T T N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IWM	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	-	3.17	2023-05-31	10.1038/s41586-023-06106-4
	8IWE	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	-	3.4	2023-05-31	10.1038/s41586-023-06106-4
	8IW9	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.08	2023-05-31	10.1038/s41586-023-06106-4
	8IW9 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.08	2023-05-31	10.1038/s41586-023-06106-4
	8IW7	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	2.97	2023-05-31	10.1038/s41586-023-06106-4
	8IW7 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-		2.97	2023-05-31	10.1038/s41586-023-06106-4
	8IW4	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	chim(NtGi1-Gs)/β1/γ2	3.49	2023-05-31	10.1038/s41586-023-06106-4
	8IW4 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-		3.49	2023-05-31	10.1038/s41586-023-06106-4
	8IW1	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-05-31	10.1038/s41586-023-06106-4
	8IW1 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.4	2023-05-31	10.1038/s41586-023-06106-4
	8ITF	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-	chim(NtGi1-Gs)/β1/γ2	3.46	2023-05-31	10.1038/s41586-023-06106-4
	8ITF (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-		3.46	2023-05-31	10.1038/s41586-023-06106-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ITF_nogp.zip

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