Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.4625402
2A:A:Y37 7.6075404
3A:A:H41 5.0075406
4A:A:L44 5.95419
5A:A:L46 5.1075418
6A:A:K53 4.5075409
7A:A:F219 5.802508
8A:A:M221 4.8408
9A:A:F222 7.175417
10A:A:R231 6.118519
11A:A:K233 4.8556109
12A:A:W234 8.8975419
13A:A:I235 5.37419
14A:A:F238 7.28167619
15A:A:I245 4.7825407
16A:A:V247 3.4425407
17A:A:D272 5.4325418
18A:A:F273 6.944169
19A:A:W277 9.058506
20A:A:W281 8.6625415
21A:A:L289 4.8754169
22A:A:F290 8.2454149
23A:A:N292 4.3775409
24A:A:F339 6.034183
25A:A:S349 3.7375407
26A:A:Y360 6.0725408
27A:A:F363 6.76254175
28A:A:T364 6.7254149
29A:A:N371 9.03754149
30A:A:F376 7.405408
31B:B:D27 6.495408
32B:B:V40 4.3525153
33B:B:H54 8.414559
34B:B:L55 7.0225406
35B:B:K57 7.06419
36B:B:I58 4.514559
37B:B:Y59 6.454518
38B:B:W63 7.5407
39B:B:Q75 6.9175419
40B:B:D76 7.365409
41B:B:I80 7.948558
42B:B:W82 13.246559
43B:B:K89 7.544559
44B:B:L95 3.958508
45B:B:W99 7.53167619
46B:B:Y105 3.416506
47B:B:Y111 5.8945204
48B:B:I123 2.93754206
49B:B:Y124 4.754506
50B:B:E130 4.0075403
51B:B:H142 6.9025489
52B:B:Y145 5.34108
53B:B:F151 3.298509
54B:B:L152 3.8025403
55B:B:T159 4.53489
56B:B:T165 3.335487
57B:B:L168 2.96446
58B:B:W169 8.725688
59B:B:Q176 6.12484
60B:B:F180 7.72547
61B:B:H183 6.742549
62B:B:D186 5.34254109
63B:B:V187 4.125449
64B:B:M188 4.2454108
65B:B:F199 5.566549
66B:B:V200 6.36526
67B:B:S201 3.376549
68B:B:C204 5.91254107
69B:B:K209 7.952546
70B:B:W211 8.066548
71B:B:F222 5.93428
72B:B:H225 7.80286729
73B:B:D228 7.08754109
74B:B:I232 4.7825428
75B:B:F235 6.076676126
76B:B:P236 5.674127
77B:B:F241 6.34333626
78B:B:T243 5.204528
79B:B:S245 5.83429
80B:B:D247 6.5975429
81B:B:T249 5.6875426
82B:B:R251 9.36528
83B:B:F253 5.864526
84B:B:R256 5.28409
85B:B:D258 5.775427
86B:B:M262 6.545404
87B:B:Y264 4.9975405
88B:B:I269 2.585404
89B:B:C271 3.83415
90B:B:F278 5.11754127
91B:B:R283 7.5965159
92B:B:Y289 5.05817
93B:B:H311 7.48569
94B:B:R314 12.396518
95B:B:T321 5.87437
96B:B:M325 3.415435
97B:B:V327 3.585466
98B:B:W332 12.41519
99B:B:D333 6.6425469
100B:B:L336 3.814557
101B:B:K337 7.572566
102B:B:W339 8.636569
103G:G:D48 8.62409
104G:G:N59 3.43539
105G:G:P60 7.27439
106G:G:F61 5.93375838
107R:R:Y36 5.5405
108R:R:N50 4.0275479
109R:R:I57 3.492507
110R:R:T67 4.624118
111R:R:N68 4.69254119
112R:R:L70 2.25754228
113R:R:L74 4.642579
114R:R:D78 6.675679
115R:R:F79 4.14407
116R:R:V85 5.9454247
117R:R:M86 2.6365237
118R:R:W98 8.73254138
119R:R:C105 7.52754139
120R:R:S114 3.505405
121R:R:F115 6.87407
122R:R:F117 4.7875495
123R:R:H122 5.83478
124R:R:D129 8.084119
125R:R:P137 5.048508
126R:R:L138 3.8575406
127R:R:Y140 4.996676117
128R:R:W157 3.385479
129R:R:Y163 7.125405
130R:R:I167 7.045405
131R:R:F168 4.7725405
132R:R:C190 7.154139
133R:R:Q191 5.9154131
134R:R:F206 6.76498
135R:R:L216 4.34406
136R:R:Y217 5.2425409
137R:R:E232 4.4425404
138R:R:M264 3.4775408
139R:R:F267 5.62167699
140R:R:W271 7.59333698
141R:R:W298 6.29405
142R:R:Y301 5.70254248
143R:R:Y302 4.2325406
144R:R:N307 5.772579
145R:R:Y311 4.72509
146R:R:W317 10.4175406
147R:R:I322 2.7575407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:N88 B:B:T86 67.086610.24NoNo076
2B:B:D83 B:B:T86 66.82025.78NoNo086
3B:B:D83 B:B:L69 74.94664.07NoNo085
4B:B:L69 B:B:Y105 74.27942.34NoYes056
5B:B:L126 B:B:Y105 27.89733.52NoYes056
6A:A:S23 B:B:N88 69.268.94NoNo077
7A:A:E27 A:A:S23 69.53792.87NoNo067
8A:A:E27 B:B:K89 70.16510.8NoYes069
9B:B:I80 B:B:K89 70.79454.36YesYes589
10B:B:I80 B:B:K78 46.16734.36YesNo588
11B:B:D76 B:B:K78 46.33316.91YesNo098
12B:B:D76 B:B:L55 23.75613.57YesYes096
13A:A:Y37 B:B:L55 23.88044.69YesYes046
14B:B:A56 B:B:D76 23.21713.09NoYes079
15A:A:Y37 B:B:A56 23.23494YesNo047
16A:A:R42 A:A:Y37 47.306813.38NoYes094
17B:B:H54 B:B:I80 26.666610.61YesYes598
18B:B:H54 B:B:I58 26.97385.3YesYes599
19B:B:C317 B:B:I58 33.32723.27NoYes079
20B:B:C317 B:B:S316 39.4183.44NoNo079
21B:B:S316 B:B:W332 39.48484.94NoYes099
22B:B:R314 B:B:W332 40.162428.99YesYes189
23A:A:W281 B:B:R314 51.61273YesYes158
24A:A:I235 A:A:W281 51.72013.52YesYes195
25A:A:I235 A:A:R231 51.1045.01YesYes199
26A:A:D272 A:A:R231 99.52945.96YesYes189
27A:A:D272 A:A:Y246 1005.75YesNo089
28A:A:F273 A:A:Y246 99.79797.22YesNo099
29A:A:F273 A:A:L289 98.99497.31YesYes1699
30A:A:C359 A:A:L289 92.64433.17NoYes059
31A:A:C359 A:A:S349 92.53073.44NoYes057
32A:A:S349 A:A:W277 94.85563.71YesYes076
33A:A:H357 A:A:W277 94.259726.45NoYes076
34A:A:H357 A:A:S286 93.65442.79NoNo078
35A:A:I382 A:A:S286 93.53227.74NoNo068
36A:A:I382 A:A:Y360 93.40974.84NoYes068
37A:A:D378 A:A:Y360 21.530210.34NoYes078
38A:A:F222 A:A:R42 47.72214.28YesNo079
39A:A:F222 A:A:F238 47.06468.57YesYes179
40A:A:F238 A:A:W234 48.71564.01YesYes199
41A:A:R231 A:A:W234 48.372911YesYes199
42A:A:D378 A:A:H362 13.93375.04NoNo079
43A:A:F290 A:A:H362 12.85925.66YesNo099
44A:A:F290 A:A:T364 12.26216.49YesYes1499
45A:A:N292 A:A:T364 11.74014.39YesYes099
46A:A:Y358 A:A:Y360 77.80823.97NoYes048
47A:A:Y358 R:R:I231 77.48044.84NoNo047
48R:R:E232 R:R:I231 77.31598.2YesNo047
49R:R:E232 R:R:R252 74.67313.49YesNo046
50A:A:L394 R:R:R252 74.33413.64NoNo086
51A:A:L388 A:A:L394 73.82384.15NoNo088
52A:A:L388 R:R:V134 72.79554.47NoNo088
53R:R:I220 R:R:V134 72.7349.22NoNo098
54R:R:I220 R:R:L260 72.5594.28NoNo097
55R:R:L260 R:R:Y217 72.38379.38NoYes079
56R:R:Y217 R:R:Y311 55.18152.98YesYes099
57R:R:L123 R:R:Y311 54.06235.86NoYes089
58R:R:L123 R:R:L74 31.05522.77NoYes789
59R:R:D78 R:R:L74 22.11315.43YesYes799
60R:R:D78 R:R:N50 43.46674.04YesYes799
61R:R:A75 R:R:N50 15.14953.13NoYes099
62R:R:A75 R:R:V53 13.13553.39NoNo099
63R:R:I57 R:R:V53 12.13833.07YesNo079
64R:R:F318 R:R:I57 10.65985.02NoYes097
65R:R:L123 R:R:N307 22.8254.12NoYes789
66R:R:D78 R:R:N307 22.78648.08YesYes799
67B:B:D290 B:B:R314 25.817521.44NoYes168
68B:B:C271 B:B:D290 25.74343.11YesNo156
69B:B:C271 B:B:Y289 24.09654.03YesYes157
70B:B:I273 B:B:Y289 16.17488.46NoYes067
71B:B:G244 B:B:I273 15.95663.53NoNo056
72B:B:G244 B:B:T243 15.73811.82NoYes058
73B:B:L336 B:B:L51 11.18955.54YesNo579
74B:B:H62 B:B:Y105 21.91883.27NoYes066
75B:B:H62 B:B:R150 21.530413.54NoNo066
76B:B:L70 B:B:W63 11.386510.25NoYes057
77B:B:V71 B:B:Y105 26.75115.05NoYes086
78B:B:V112 B:B:V71 25.26854.81NoNo088
79B:B:V112 B:B:Y124 24.89853.79NoYes086
80B:B:L95 B:B:Y124 43.77893.52YesYes086
81B:B:L126 B:B:V133 26.04692.98NoNo054
82B:B:V133 B:B:Y124 24.93493.79NoYes046
83B:B:C114 B:B:L95 40.74643.17NoYes088
84B:B:C114 B:B:G115 39.98731.96NoNo089
85B:B:G115 B:B:T102 38.4681.82NoNo098
86B:B:C149 B:B:T102 37.70783.38NoNo088
87B:B:C121 B:B:C149 16.93583.64NoNo088
88B:B:C121 B:B:L139 15.40663.17NoNo089
89B:B:L139 B:B:R137 14.72443.64NoNo095
90B:B:I123 B:B:R137 13.95282.51YesNo065
91B:B:C149 B:B:T159 20.01473.38NoYes089
92B:B:T159 B:B:W169 12.32547.28YesYes898
93B:B:L192 B:B:R150 21.14163.64NoNo056
94B:B:F199 B:B:L192 17.58823.65YesNo095
95B:B:F199 B:B:W211 10.443510.02YesYes498
96B:B:W297 B:B:Y289 10.26415.79NoYes087
97B:B:W297 B:B:Y264 10.46932.89NoYes085
98R:R:F79 R:R:N50 28.58162.42YesYes079
99R:R:F79 R:R:V83 17.69417.87YesNo074
100R:R:T84 R:R:V83 17.19493.17NoNo054
101R:R:T84 R:R:V85 16.69531.59NoYes057
102R:R:V85 R:R:Y301 10.63995.05YesYes2478
103R:R:F79 R:R:V47 10.1672.62YesNo076
104R:R:M264 R:R:Y217 15.13284.79YesYes089
105R:R:M213 R:R:M264 14.34364.33NoYes088
106R:R:F267 R:R:M213 14.13897.46YesNo098
107R:R:F267 R:R:W271 10.86353.01YesYes998
108B:B:L51 B:B:L70 10.56252.77NoNo595
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IW1
Class A
SubFamily Orphan
Type A orphans
SubType TAAR9
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.4
Date 2023-05-31
D.O.I. 10.1038/s41586-023-06106-4
Net Summary
Imin 2.77
Number of Linked Nodes 821
Number of Links 956
Number of Hubs 147
Number of Links mediated by Hubs 530
Number of Communities 25
Number of Nodes involved in Communities 184
Number of Links involved in Communities 257
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 817939
Length Of Smallest Path 3
Average Path Length 37.1656
Length of Longest Path 73
Minimum Path Strength 1.295
Average Path Strength 6.03224
Maximum Path Strength 27.33
Minimum Path Correlation 0.7
Average Path Correlation 0.979493
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 42.9817
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.1413
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8IW1_Chain_A
TLSAEDKAA VERSKMIEK QLQKERLAY KATHRLLLL GADNSGKST 
IVKQMRGIF ETRFQVDKV NFHMFDVGR RKWIQCFND VTAIIYVAD 
CSDYLRESL DDFESIWNN RWLRTISII LFLNKQDML AEKVLAGKS 
KIEDYFPEY ANYTVPEDA TPDAGEDPK VTRAKFFIR DLFLRISTA 
TGDGKHYCY PHFTCAVDT ENARRIFND CRDIIQRMH LKQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IW1_Chain_B
RQEAEQLKN QIRDARKAC ADATLSQIT NNIDPVGRI QMRTRRTLR 
GHLAKIYAM HWGTDSRLL VSASQDGKL IIWDSYTTN KVHAIPLRS 
SWVMTCAYA PSGNYVACG GLDNICSIY NLKTREGNV RVSRELAGH 
TGYLSCCRF LDDNQIVTS SGDTTCALW DIETGQQTT TFTGHTGDV 
MSLSLAPDT RLFVSGACD ASAKLWDVR EGMCRQTFT GHESDINAI 
CFFPNGNAF ATGSDDATC RLFDLRADQ ELMTYSHDN IICGITSVS 
FSKSGRLLL AGYDDFNCN VWDALKADR AGVLAGHDN RVSCLGVTD 
DGMAVATGS WDSFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IW1_Chain_G
VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL TPVPASENP 
FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5QD04
Sequence
>8IW1_Chain_R
PRAILYGVL GLGALLAVF GNLLVIIAI LHFKQLHTP TNFLVASLA 
CADFLVGVT VMPFSTVRS VESCWYFGE SYCKFHTCF DTSFCFASL 
FHLCCISID RYIAVTDPL TYPTKFTVS VSGLCIALS WFFSVTYSF 
SIFYTGCQA PLNQNWVLL CFLLFFLPT VVMVFLYGR IFLVAKYQA 
RKIEGSYKE RVAKRERKA AKTLGIAMA AFLVSWLPY IIDAVIDAY 
MNFITPAYV YEILVWCVY YNSAMNPLI YAFFYPWFR KAIKLIVSG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ITFAOrphanA orphansTAAR9Mus musculusDMCHA-chim(NtGi1-Gs)/&β;1/&γ;23.462023-05-3110.1038/s41586-023-06106-4
8IW1AOrphanA orphansTAAR9Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;23.42023-05-3110.1038/s41586-023-06106-4
8IW4AOrphanA orphansTAAR9Mus musculusSpermidine-chim(NtGi1-Gs)/&β;1/&γ;23.492023-05-3110.1038/s41586-023-06106-4
8IW7AOrphanA orphansTAAR9Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;22.972023-05-3110.1038/s41586-023-06106-4
8IW9AOrphanA orphansTAAR9Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;23.082023-05-3110.1038/s41586-023-06106-4
8IWEAOrphanA orphansTAAR9Mus musculusSpermidine--3.42023-05-3110.1038/s41586-023-06106-4
8IWMAOrphanA orphansTAAR9Mus musculus2-Phenylethylamine--3.172023-05-3110.1038/s41586-023-06106-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IW1.zip



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