Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.4625402
2A:A:Y37 7.6075404
3A:A:H41 5.0075406
4A:A:L44 5.95419
5A:A:L46 5.1075418
6A:A:K53 4.5075409
7A:A:F219 6.555408
8A:A:F222 7.175417
9A:A:R231 6.118519
10A:A:K233 4.354109
11A:A:W234 8.8975419
12A:A:I235 5.37419
13A:A:F238 7.28167619
14A:A:V247 3.4425407
15A:A:D272 5.4325418
16A:A:F273 6.944149
17A:A:W277 9.058506
18A:A:L289 4.8754149
19A:A:F290 8.2454119
20A:A:N292 4.3775409
21A:A:K307 14.13406
22A:A:F339 6.034163
23A:A:Y360 6.6475408
24A:A:F363 6.76254155
25A:A:T364 6.7254119
26A:A:N371 9.03754119
27A:A:F376 7.405408
28A:A:L394 3.71408
29B:B:D27 8.22254188
30B:B:V40 4.352583
31B:B:H54 8.414539
32B:B:L55 7.0225406
33B:B:K57 7.06419
34B:B:I58 4.514539
35B:B:Y59 6.454518
36B:B:W63 7.5407
37B:B:Q75 6.9175419
38B:B:D76 7.365409
39B:B:I80 7.948538
40B:B:W82 13.246539
41B:B:K89 7.544539
42B:B:L95 3.958508
43B:B:W99 7.53167619
44B:B:Y105 3.416506
45B:B:Y111 5.8945204
46B:B:I123 2.93754206
47B:B:Y124 4.754506
48B:B:E130 4.0075403
49B:B:H142 6.9025469
50B:B:Y145 5.34108
51B:B:F151 3.298509
52B:B:T159 4.53469
53B:B:T165 3.335467
54B:B:W169 9.908568
55B:B:F180 7.72577
56B:B:V187 4.125479
57B:B:F199 5.566579
58B:B:V200 7.205426
59B:B:S201 3.5225479
60B:B:C204 5.91254107
61B:B:K209 7.952576
62B:B:W211 8.066578
63B:B:F222 5.93428
64B:B:H225 7.80286729
65B:B:I232 4.7825428
66B:B:F235 6.076676126
67B:B:F241 6.34333626
68B:B:T243 5.204528
69B:B:S245 5.83429
70B:B:D247 6.5975429
71B:B:T249 5.6875426
72B:B:R251 9.36528
73B:B:F253 5.864526
74B:B:D258 4.285427
75B:B:M262 6.545404
76B:B:I269 2.585404
77B:B:C271 3.83415
78B:B:R283 7.49689
79B:B:Y289 5.35714717
80B:B:H311 8.6575449
81B:B:R314 14.745418
82B:B:T321 5.874197
83B:B:W332 12.41519
84B:B:D333 6.6425449
85B:B:F335 4.76444
86B:B:K337 8.715446
87B:B:W339 8.636549
88G:G:D48 7.982509
89G:G:N59 3.5875409
90G:G:P60 7.27459
91G:G:F61 5.93375858
92R:R:Y36 5.185405
93R:R:I57 3.492507
94R:R:D78 9.04754239
95R:R:M86 2.89254257
96R:R:W98 6.8065278
97R:R:S114 3.505405
98R:R:F115 10.3525407
99R:R:H122 5.834248
100R:R:D129 8.084139
101R:R:P137 5.048508
102R:R:L138 3.8575406
103R:R:Y140 4.996676137
104R:R:W157 3.3854249
105R:R:Y163 6.8225405
106R:R:F168 6.97405
107R:R:F206 6.266598
108R:R:E232 4.735404
109R:R:M264 3.4775408
110R:R:F267 5.62167699
111R:R:W271 7.59333698
112R:R:D281 8.06254283
113R:R:W298 7.7125405
114R:R:Y301 5.70254268
115R:R:Y302 3.645406
116R:R:Y311 5.155409
117R:R:W317 10.4175406
118R:R:I322 2.7575407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 49.324.07NoNo085
2B:B:L69 B:B:Y105 48.54282.34NoYes056
3B:B:D83 B:B:R68 53.554113.1NoNo085
4B:B:R68 B:B:Y85 53.935532.92NoNo054
5B:B:Y85 G:G:F61 49.70324.13NoYes548
6B:B:S84 G:G:F61 57.30567.93NoYes558
7B:B:S84 B:B:W63 58.75484.94NoYes057
8B:B:L70 B:B:W63 81.307110.25NoYes057
9B:B:L70 B:B:W82 81.61444.56NoYes059
10B:B:I80 B:B:W82 67.015318.79YesYes389
11B:B:I80 B:B:K78 62.04734.36YesNo388
12B:B:D76 B:B:K78 62.74756.91YesNo098
13B:B:D76 B:B:L55 32.366513.57YesYes096
14A:A:Y37 B:B:L55 32.45584.69YesYes046
15B:B:A56 B:B:D76 31.71983.09NoYes079
16A:A:Y37 B:B:A56 31.73464YesNo047
17A:A:R42 A:A:Y37 64.447713.38NoYes094
18A:A:F222 A:A:R42 64.98574.28YesNo079
19A:A:F222 A:A:F238 63.85738.57YesYes179
20A:A:F238 A:A:W234 68.25314.01YesYes199
21A:A:R231 A:A:W234 68.152911YesYes199
22A:A:D272 A:A:R231 99.39135.96YesYes189
23A:A:D272 A:A:Y246 1005.75YesNo089
24A:A:F273 A:A:Y246 99.76137.22YesNo099
25A:A:F273 A:A:L289 98.79637.31YesYes1499
26A:A:L289 A:A:L291 97.24874.15YesNo098
27A:A:F363 A:A:L291 97.1176.09YesNo058
28A:A:F363 A:A:Q294 87.08825.86YesNo1556
29A:A:C365 A:A:Q294 87.3467.63NoNo086
30A:A:C365 A:A:D295 87.19696.22NoNo089
31A:A:D295 A:A:M296 87.05048.32NoNo096
32A:A:K293 A:A:M296 89.77835.76NoNo096
33A:A:K293 A:A:N292 89.12356.99NoYes099
34A:A:N292 A:A:T364 85.88824.39YesYes099
35A:A:F290 A:A:T364 84.99946.49YesYes1199
36A:A:F290 A:A:I245 10.63187.54YesNo097
37B:B:C317 B:B:I58 23.49783.27NoYes079
38B:B:C317 B:B:S316 23.78553.44NoNo079
39B:B:S316 B:B:W332 23.88794.94NoYes099
40B:B:R314 B:B:W332 20.168428.99YesYes189
41A:A:Q236 B:B:R314 31.76074.67NoYes088
42A:A:Q236 A:A:W281 31.635913.14NoNo085
43A:A:I235 A:A:W281 31.39443.52YesNo095
44B:B:H54 B:B:I58 15.03555.3YesYes399
45A:A:F290 A:A:H362 76.265.66YesNo099
46A:A:D378 A:A:H362 76.29873.78NoNo079
47A:A:D378 A:A:Y360 75.909812.64NoYes078
48A:A:Y358 A:A:Y360 75.2633.97NoYes048
49A:A:Y358 R:R:I231 74.844.84NoNo047
50R:R:E232 R:R:I231 74.62778.2YesNo047
51R:R:E232 R:R:R252 71.68583.49YesNo046
52A:A:L394 R:R:R252 71.24793.64YesNo086
53A:A:L388 A:A:L394 70.14614.15NoYes088
54A:A:L388 R:R:V134 68.80854.47NoNo088
55R:R:I220 R:R:V134 68.6789.22NoNo098
56R:R:I220 R:R:L260 68.44974.28NoNo097
57R:R:L260 R:R:Y217 68.22079.38NoNo079
58R:R:M264 R:R:Y217 66.36864.79YesNo089
59R:R:M213 R:R:M264 65.66464.33NoYes088
60R:R:F267 R:R:M213 65.42877.46YesNo098
61R:R:F267 R:R:W271 60.99783.01YesYes998
62R:R:N303 R:R:W271 52.95827.91NoYes098
63R:R:N303 R:R:N307 52.16076.81NoNo099
64R:R:L74 R:R:N307 50.00896.87NoNo099
65R:R:H122 R:R:L74 49.46515.14YesNo089
66R:R:H122 R:R:S73 28.36575.58YesNo089
67R:R:I153 R:R:S73 28.051812.39NoNo089
68R:R:G150 R:R:I153 27.73733.53NoNo048
69R:R:G150 R:R:S149 27.42223.71NoNo047
70R:R:F69 R:R:S149 26.15625.28NoNo057
71R:R:F69 R:R:V146 25.51975.24NoNo053
72R:R:P66 R:R:V146 25.20063.53NoNo063
73R:R:F144 R:R:P66 24.8814.33NoNo066
74R:R:D129 R:R:F144 16.032613.14YesNo1396
75B:B:D290 B:B:R314 46.04921.44NoYes168
76B:B:C271 B:B:D290 45.9443.11YesNo156
77B:B:C271 B:B:Y289 34.54064.03YesYes157
78B:B:I273 B:B:Y289 23.00428.46NoYes067
79B:B:G244 B:B:I273 22.69033.53NoNo056
80B:B:G244 B:B:T243 22.37571.82NoYes058
81B:B:F253 B:B:T243 11.44515.19YesYes268
82B:B:M325 G:G:P49 24.34813.35NoNo057
83G:G:D48 G:G:P49 24.0534.83YesNo097
84G:G:D48 G:G:L51 15.004116.29YesNo096
85B:B:R283 G:G:L51 10.95694.86YesNo896
86B:B:I37 B:B:R283 17.19193.76NoYes029
87B:B:I37 B:B:T34 15.93273.04NoNo025
88B:B:L30 B:B:T34 15.30235.9NoNo055
89B:B:I43 B:B:V40 13.16143.07NoYes033
90B:B:I43 B:B:M45 13.62844.37NoNo034
91B:B:L308 B:B:M45 13.87284.24NoNo074
92B:B:L308 B:B:W339 14.384519.36NoYes079
93B:B:H62 B:B:Y105 16.87743.27NoYes066
94B:B:H62 B:B:R150 16.443813.54NoNo066
95B:B:D323 B:B:M325 20.25974.16NoNo075
96B:B:D323 B:B:T321 20.49334.34NoYes1977
97B:B:T321 B:B:W63 22.276210.92YesYes077
98B:B:V71 B:B:Y105 30.44915.05NoYes086
99B:B:V112 B:B:V71 28.78474.81NoNo088
100B:B:V112 B:B:Y124 28.36723.79NoYes086
101B:B:L95 B:B:Y124 23.73653.52YesYes086
102B:B:C114 B:B:L95 22.03553.17NoYes088
103B:B:C114 B:B:G115 21.60881.96NoNo089
104B:B:G115 B:B:T102 20.75371.82NoNo098
105B:B:C149 B:B:T102 20.32533.38NoNo088
106B:B:C149 B:B:T159 10.17163.38NoYes089
107B:B:L192 B:B:R150 16.00973.64NoNo056
108B:B:F199 B:B:L192 15.5753.65YesNo095
109B:B:S281 G:G:D48 10.77868.83NoYes099
110B:B:V327 B:B:W339 21.16583.68NoYes069
111B:B:L286 B:B:V327 21.94284.47NoNo076
112B:B:L286 B:B:V296 22.4754.47NoNo075
113B:B:G306 B:B:V296 23.00911.84NoNo045
114B:B:G306 B:B:V307 23.27891.84NoNo043
115B:B:N295 B:B:V307 13.07064.43NoNo063
116B:B:N295 B:B:Y289 13.36258.14NoYes067
117B:B:C271 B:B:D291 10.97386.22YesNo158
118B:B:N293 B:B:V307 10.48965.91NoNo053
119B:B:D291 B:B:N293 10.7284.04NoNo085
120R:R:H122 R:R:W157 23.89854.23YesYes2489
121R:R:F115 R:R:W157 23.27413.01YesYes079
122R:R:F111 R:R:F115 19.688523.58NoYes057
123R:R:F111 R:R:T84 19.359115.56NoNo055
124R:R:T84 R:R:Y104 12.65113.75NoNo056
125R:R:F88 R:R:Y104 11.96774.13NoNo056
126R:R:F88 R:R:H108 11.62524.53NoNo055
127R:R:H108 R:R:V85 10.93836.92NoNo057
128R:R:T65 R:R:T67 13.00083.14NoNo088
129R:R:N68 R:R:T65 12.32295.85NoNo098
130R:R:F318 R:R:N68 10.28987.25NoNo099
131R:R:F318 R:R:I57 14.42315.02NoYes097
132A:A:I235 A:A:R231 30.9725.01YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IW1
Class A
SubFamily Orphan
Type Orphan
SubType TA9
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.4
Date 2023-05-31
D.O.I. 10.1038/s41586-023-06106-4
Net Summary
Imin 3.01
Number of Linked Nodes 809
Number of Links 901
Number of Hubs 118
Number of Links mediated by Hubs 443
Number of Communities 28
Number of Nodes involved in Communities 156
Number of Links involved in Communities 201
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 607174
Length Of Smallest Path 3
Average Path Length 39.0643
Length of Longest Path 90
Minimum Path Strength 1.165
Average Path Strength 6.55312
Maximum Path Strength 25.215
Minimum Path Correlation 0.7
Average Path Correlation 0.977312
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 43.6698
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.9273
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8IW1_Chain_A
TLSAEDKAA VERSKMIEK QLQKERLAY KATHRLLLL GADNSGKST 
IVKQMRGIF ETRFQVDKV NFHMFDVGR RKWIQCFND VTAIIYVAD 
CSDYLRESL DDFESIWNN RWLRTISII LFLNKQDML AEKVLAGKS 
KIEDYFPEY ANYTVPEDA TPDAGEDPK VTRAKFFIR DLFLRISTA 
TGDGKHYCY PHFTCAVDT ENARRIFND CRDIIQRMH LKQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IW1_Chain_B
RQEAEQLKN QIRDARKAC ADATLSQIT NNIDPVGRI QMRTRRTLR 
GHLAKIYAM HWGTDSRLL VSASQDGKL IIWDSYTTN KVHAIPLRS 
SWVMTCAYA PSGNYVACG GLDNICSIY NLKTREGNV RVSRELAGH 
TGYLSCCRF LDDNQIVTS SGDTTCALW DIETGQQTT TFTGHTGDV 
MSLSLAPDT RLFVSGACD ASAKLWDVR EGMCRQTFT GHESDINAI 
CFFPNGNAF ATGSDDATC RLFDLRADQ ELMTYSHDN IICGITSVS 
FSKSGRLLL AGYDDFNCN VWDALKADR AGVLAGHDN RVSCLGVTD 
DGMAVATGS WDSFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IW1_Chain_G
VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL TPVPASENP 
FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5QD04
Sequence
>8IW1_Chain_R
PRAILYGVL GLGALLAVF GNLLVIIAI LHFKQLHTP TNFLVASLA 
CADFLVGVT VMPFSTVRS VESCWYFGE SYCKFHTCF DTSFCFASL 
FHLCCISID RYIAVTDPL TYPTKFTVS VSGLCIALS WFFSVTYSF 
SIFYTGCQA PLNQNWVLL CFLLFFLPT VVMVFLYGR IFLVAKYQA 
RKIEGSYKE RVAKRERKA AKTLGIAMA AFLVSWLPY IIDAVIDAY 
MNFITPAYV YEILVWCVY YNSAMNPLI YAFFYPWFR KAIKLIVSG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IWMAOrphanOrphanTA9Mus musculus2-Phenylethylamine--3.172023-05-3110.1038/s41586-023-06106-4
8IWEAOrphanOrphanTA9Mus musculusSpermidine--3.42023-05-3110.1038/s41586-023-06106-4
8IW9AOrphanOrphanTA9Mus musculus--chim(NtGi1-Gs)/β1/γ23.082023-05-3110.1038/s41586-023-06106-4
8IW9 (No Gprot) AOrphanOrphanTA9Mus musculus--3.082023-05-3110.1038/s41586-023-06106-4
8IW7AOrphanOrphanTA9Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ22.972023-05-3110.1038/s41586-023-06106-4
8IW7 (No Gprot) AOrphanOrphanTA9Mus musculus2-Phenylethylamine-2.972023-05-3110.1038/s41586-023-06106-4
8IW4AOrphanOrphanTA9Mus musculusSpermidine-chim(NtGi1-Gs)/β1/γ23.492023-05-3110.1038/s41586-023-06106-4
8IW4 (No Gprot) AOrphanOrphanTA9Mus musculusSpermidine-3.492023-05-3110.1038/s41586-023-06106-4
8IW1AOrphanOrphanTA9Mus musculus--chim(NtGi1-Gs)/β1/γ23.42023-05-3110.1038/s41586-023-06106-4
8IW1 (No Gprot) AOrphanOrphanTA9Mus musculus--3.42023-05-3110.1038/s41586-023-06106-4
8ITFAOrphanOrphanTA9Mus musculusDMCHA-chim(NtGi1-Gs)/β1/γ23.462023-05-3110.1038/s41586-023-06106-4
8ITF (No Gprot) AOrphanOrphanTA9Mus musculusDMCHA-3.462023-05-3110.1038/s41586-023-06106-4




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