psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C186	R:R:C22	7.28	No	No	0	3	8
2	R:R:C22	R:R:V187	5.12	No	No	0	8	3
3	R:R:K24	R:R:S96	3.06	No	No	0	5	3
4	R:R:A183	R:R:K24	3.21	No	No	0	2	5
5	R:R:C97	R:R:S26	3.44	No	No	0	4	3
6	R:R:S96	R:R:Y27	3.82	No	No	0	3	1
7	R:R:Y27	R:R:Y291	9.93	No	No	0	1	2
8	R:R:A28	R:R:P29	1.87	No	No	0	4	3
9	R:R:P31	R:R:W30	4.05	No	No	0	3	1
10	R:R:I34	R:R:R32	3.76	No	No	0	5	4
11	R:R:L35	R:R:L39	5.54	No	Yes	0	5	7
12	R:R:T90	R:R:Y36	2.5	No	Yes	1	6	5
13	R:R:V94	R:R:Y36	11.36	No	Yes	1	6	5
14	R:R:E95	R:R:Y36	4.49	No	Yes	1	5	5
15	R:R:L39	R:R:T90	7.37	Yes	No	1	7	6
16	R:R:L39	R:R:W298	12.53	Yes	Yes	1	7	5
17	R:R:G42	R:R:Y302	2.9	No	No	4	6	6
18	R:R:A305	R:R:G42	1.95	Yes	No	4	7	6
19	R:R:F48	R:R:L44	2.44	No	No	0	4	5
20	R:R:A46	R:R:G82	1.95	No	Yes	0	7	7
21	R:R:A305	R:R:A46	1.79	Yes	No	0	7	7
22	R:R:F48	R:R:V47	3.93	No	No	0	4	6
23	R:R:F79	R:R:V47	3.93	Yes	No	0	7	6
24	R:R:G82	R:R:V47	1.84	Yes	No	0	7	6
25	R:R:A75	R:R:N50	4.69	No	Yes	0	9	9
26	R:R:D78	R:R:N50	5.39	No	Yes	0	9	9
27	R:R:F79	R:R:N50	3.62	Yes	Yes	0	7	9
28	R:R:N50	R:R:P308	9.77	Yes	No	0	9	9
29	R:R:I322	R:R:L52	2.85	No	No	0	7	7
30	R:R:A312	R:R:V53	3.39	No	No	0	7	9
31	R:R:F313	R:R:V53	3.93	No	No	0	5	9
32	R:R:A75	R:R:I54	3.25	No	No	0	9	8
33	R:R:I325	R:R:I55	2.94	No	No	0	6	4
34	R:R:A321	R:R:A56	1.79	No	No	0	7	7
35	R:R:A72	R:R:I57	4.87	No	No	0	6	7
36	R:R:F318	R:R:I57	5.02	Yes	No	0	9	7
37	R:R:F60	R:R:H59	4.53	Yes	No	0	5	6
38	R:R:A321	R:R:F60	4.16	No	Yes	0	7	5
39	R:R:F60	R:R:L324	3.65	Yes	No	0	5	4
40	R:R:F60	R:R:I325	2.51	Yes	No	0	5	6
41	R:R:H64	R:R:K61	3.93	No	No	0	7	6
42	R:R:F318	R:R:L63	2.44	Yes	No	0	9	8
43	R:R:F69	R:R:H64	2.26	No	No	0	5	7
44	R:R:P66	R:R:T65	3.5	No	No	0	6	8
45	R:R:T65	R:R:T67	4.71	No	No	0	8	8
46	R:R:N68	R:R:T65	7.31	No	No	0	9	8
47	R:R:P66	R:R:V146	3.53	No	No	0	6	3
48	R:R:D129	R:R:T67	5.78	No	No	2	9	8
49	R:R:T67	R:R:Y140	2.5	No	Yes	2	8	7
50	R:R:F318	R:R:N68	4.83	Yes	No	0	9	9
51	R:R:F69	R:R:V146	3.93	No	No	0	5	3
52	R:R:F69	R:R:S149	2.64	No	No	0	5	7
53	R:R:C125	R:R:L70	3.17	No	No	0	6	8
54	R:R:F144	R:R:L70	2.44	Yes	No	0	6	8
55	R:R:C76	R:R:S73	3.44	No	Yes	0	7	9
56	R:R:H122	R:R:S73	9.76	Yes	Yes	1	8	9
57	R:R:I153	R:R:S73	10.84	Yes	Yes	1	8	9
58	R:R:S73	R:R:W157	2.47	Yes	Yes	1	9	9
59	R:R:H122	R:R:L74	6.43	Yes	No	1	8	9
60	R:R:L123	R:R:L74	2.77	No	No	1	8	9
61	R:R:L74	R:R:N307	9.61	No	Yes	1	9	9
62	R:R:A77	R:R:W157	3.89	No	Yes	0	8	9
63	R:R:D78	R:R:S304	8.83	No	No	0	9	9
64	R:R:D78	R:R:N307	2.69	No	Yes	0	9	9
65	R:R:F79	R:R:V83	7.87	Yes	No	0	7	4
66	R:R:F115	R:R:L80	9.74	Yes	No	1	7	7
67	R:R:L80	R:R:W157	2.28	No	Yes	1	7	9
68	R:R:G82	R:R:V81	3.68	Yes	Yes	1	7	7
69	R:R:M86	R:R:V81	6.09	Yes	Yes	1	7	7
70	R:R:F115	R:R:V81	3.93	Yes	Yes	1	7	7
71	R:R:S304	R:R:V81	3.23	No	Yes	1	9	7
72	R:R:G82	R:R:M86	5.24	Yes	Yes	1	7	7
73	R:R:T84	R:R:V85	4.76	No	Yes	0	5	7
74	R:R:F111	R:R:T84	2.59	No	No	0	5	5
75	R:R:S89	R:R:V85	3.23	Yes	Yes	1	6	7
76	R:R:H108	R:R:V85	9.69	Yes	Yes	1	5	7
77	R:R:D112	R:R:V85	4.38	Yes	Yes	1	6	7
78	R:R:V85	R:R:Y301	5.05	Yes	Yes	1	7	8
79	R:R:M86	R:R:P87	5.03	Yes	No	0	7	8
80	R:R:M86	R:R:W298	3.49	Yes	Yes	1	7	5
81	R:R:M86	R:R:Y301	4.79	Yes	Yes	1	7	8
82	R:R:M86	R:R:S304	3.07	Yes	No	1	7	9
83	R:R:F88	R:R:W98	2	No	Yes	1	5	8
84	R:R:F100	R:R:F88	11.79	No	No	1	6	5
85	R:R:F88	R:R:H108	3.39	No	Yes	1	5	5
86	R:R:H108	R:R:S89	4.18	Yes	Yes	1	5	6
87	R:R:S89	R:R:W298	3.71	Yes	Yes	1	6	5
88	R:R:S89	R:R:Y301	8.9	Yes	Yes	1	6	8
89	R:R:T90	R:R:W298	6.06	No	Yes	1	6	5
90	R:R:F100	R:R:V91	3.93	No	No	0	6	4
91	R:R:R92	R:R:W98	4	Yes	Yes	1	5	8
92	R:R:H108	R:R:R92	2.26	Yes	Yes	1	5	5
93	R:R:E294	R:R:R92	10.47	No	Yes	0	4	5
94	R:R:E294	R:R:S93	4.31	No	No	0	4	4
95	R:R:S93	R:R:W298	4.94	No	Yes	0	4	5
96	R:R:E95	R:R:V94	7.13	No	No	1	5	6
97	R:R:C97	R:R:Y99	9.41	No	No	0	4	2
98	R:R:F100	R:R:W98	11.02	No	Yes	1	6	8
99	R:R:H108	R:R:W98	3.17	Yes	Yes	1	5	8
100	R:R:C105	R:R:C190	7.28	No	No	0	9	9
101	R:R:K106	R:R:Y169	4.78	No	Yes	0	6	5
102	R:R:F107	R:R:Y169	5.16	No	Yes	0	5	5
103	R:R:F168	R:R:T109	5.19	Yes	No	0	5	5
104	R:R:C110	R:R:Y169	4.03	No	Yes	0	6	5
105	R:R:F111	R:R:F115	4.29	No	Yes	0	5	7
106	R:R:D112	R:R:T113	4.34	Yes	Yes	1	6	4
107	R:R:D112	R:R:Y301	12.64	Yes	Yes	1	6	8
108	L:L:?1	R:R:D112	11.98	Yes	Yes	1	0	6
109	R:R:T113	R:R:Y163	4.99	Yes	Yes	1	4	5
110	R:R:S164	R:R:T113	3.2	No	Yes	0	7	4
111	R:R:F168	R:R:T113	10.38	Yes	Yes	1	5	4
112	L:L:?1	R:R:T113	9.11	Yes	Yes	1	0	4
113	R:R:F115	R:R:S114	2.64	Yes	Yes	1	7	5
114	R:R:S114	R:R:W157	2.47	Yes	Yes	1	5	9
115	R:R:S114	R:R:S160	6.52	Yes	No	1	5	8
116	R:R:S114	R:R:V161	3.23	Yes	No	0	5	3
117	R:R:S114	R:R:S164	4.89	Yes	No	0	5	7
118	R:R:F115	R:R:W157	4.01	Yes	Yes	1	7	9
119	R:R:C116	R:R:W271	2.61	No	Yes	0	7	8
120	L:L:?1	R:R:C116	2.8	Yes	No	0	0	7
121	R:R:F117	R:R:L120	2.44	Yes	Yes	1	5	7
122	R:R:F117	R:R:F121	3.22	Yes	Yes	1	5	5
123	R:R:F117	R:R:Y163	7.22	Yes	Yes	1	5	5
124	R:R:F117	R:R:L205	4.87	Yes	No	1	5	4
125	R:R:F117	R:R:W271	2	Yes	Yes	1	5	8
126	R:R:A118	R:R:W157	2.59	No	Yes	1	7	9
127	R:R:A118	R:R:S160	3.42	No	No	1	7	8
128	R:R:F121	R:R:L120	2.44	Yes	Yes	1	5	7
129	R:R:L120	R:R:P209	9.85	Yes	Yes	1	7	9
130	R:R:F267	R:R:L120	2.44	Yes	Yes	0	9	7
131	R:R:F121	R:R:S156	3.96	Yes	No	0	5	7
132	R:R:F121	R:R:F159	2.14	Yes	No	0	5	4
133	R:R:F121	R:R:P209	4.33	Yes	Yes	1	5	9
134	R:R:H122	R:R:I153	3.98	Yes	Yes	1	8	8
135	R:R:H122	R:R:S156	9.76	Yes	No	0	8	7
136	R:R:H122	R:R:W157	4.23	Yes	Yes	1	8	9
137	R:R:L123	R:R:N307	8.24	No	Yes	1	8	9
138	R:R:L123	R:R:Y311	7.03	No	Yes	1	8	9
139	R:R:C124	R:R:P209	3.77	No	Yes	0	7	9
140	R:R:C125	R:R:C152	7.28	No	No	0	6	6
141	R:R:I126	R:R:Y311	4.84	No	Yes	0	9	9
142	R:R:M213	R:R:S127	6.13	No	No	3	8	8
143	R:R:L216	R:R:S127	4.5	Yes	No	0	6	8
144	R:R:S127	R:R:Y217	7.63	No	Yes	3	8	9
145	R:R:I128	R:R:L216	2.85	No	Yes	0	7	6
146	R:R:D129	R:R:Y140	6.9	No	Yes	2	9	7
147	R:R:D129	R:R:F144	21.5	No	Yes	2	9	6
148	R:R:I220	R:R:R130	2.51	Yes	No	0	9	9
149	R:R:R130	R:R:Y315	3.09	No	Yes	0	9	8
150	R:R:T135	R:R:Y131	16.23	No	Yes	0	6	8
151	R:R:L216	R:R:Y131	17.58	Yes	Yes	0	6	8
152	R:R:R219	R:R:Y131	9.26	No	Yes	0	4	8
153	R:R:I220	R:R:Y131	3.63	Yes	Yes	0	9	8
154	R:R:I132	R:R:Y140	2.42	No	Yes	0	5	7
155	R:R:A133	R:R:Y140	9.34	No	Yes	0	8	7
156	R:R:I220	R:R:V134	4.61	Yes	No	0	9	8
157	R:R:V134	R:R:V223	3.21	No	No	0	8	5
158	R:R:D136	R:R:P137	3.22	No	No	0	6	8
159	R:R:D136	R:R:T139	4.34	No	No	6	6	5
160	R:R:D136	R:R:K143	4.15	No	No	6	6	4
161	R:R:T139	R:R:T142	4.71	No	No	0	5	4
162	R:R:K143	R:R:T139	4.5	No	No	6	4	5
163	R:R:P141	R:R:Y140	4.17	No	Yes	0	4	7
164	R:R:F144	R:R:Y140	5.16	Yes	Yes	2	6	7
165	R:R:F144	R:R:V148	6.55	Yes	No	0	6	6
166	R:R:S147	R:R:T145	3.2	No	No	0	4	7
167	R:R:G150	R:R:S149	1.86	No	No	0	4	7
168	R:R:G150	R:R:I153	1.76	No	Yes	0	4	8
169	R:R:L151	R:R:L155	2.77	No	No	0	3	2
170	R:R:I153	R:R:W157	2.35	Yes	Yes	1	8	9
171	R:R:S160	R:R:W157	3.71	No	Yes	1	8	9
172	R:R:F158	R:R:T162	2.59	No	No	0	4	4
173	R:R:I167	R:R:Y163	6.04	Yes	Yes	1	5	5
174	R:R:L201	R:R:Y163	2.34	No	Yes	1	5	5
175	R:R:C202	R:R:Y163	5.38	No	Yes	0	5	5
176	R:R:L205	R:R:Y163	7.03	No	Yes	1	4	5
177	R:R:F165	R:R:Y169	7.22	No	Yes	0	4	5
178	R:R:F168	R:R:I167	3.77	Yes	Yes	1	5	5
179	R:R:I167	R:R:W198	8.22	Yes	No	1	5	6
180	R:R:I167	R:R:L201	2.85	Yes	No	1	5	5
181	R:R:F168	R:R:N173	7.25	Yes	Yes	1	5	4
182	R:R:A192	R:R:F168	2.77	No	Yes	1	4	5
183	R:R:F168	R:R:L194	4.87	Yes	Yes	1	5	4
184	L:L:?1	R:R:F168	7.52	Yes	Yes	1	0	5
185	R:R:G171	R:R:T170	1.82	No	No	0	1	5
186	R:R:E174	R:R:N173	5.26	Yes	Yes	1	4	4
187	R:R:L194	R:R:N173	4.12	Yes	Yes	1	4	4
188	R:R:E174	R:R:L184	9.28	Yes	No	1	4	4
189	R:R:E174	R:R:P193	6.29	Yes	Yes	1	4	3
190	R:R:E178	R:R:G176	4.91	No	No	0	4	3
191	R:R:E179	R:R:I177	9.56	No	No	0	3	1
192	R:R:F286	R:R:I177	7.54	No	No	0	2	1
193	R:R:E179	R:R:N285	5.26	No	No	0	3	1
194	R:R:L180	R:R:Q191	3.99	No	No	0	2	1
195	R:R:F286	R:R:L180	7.31	No	No	0	2	2
196	R:R:A183	R:R:C186	1.81	No	No	0	2	3
197	R:R:L184	R:R:Q191	3.99	No	No	0	4	1
198	R:R:L184	R:R:P193	8.21	No	Yes	1	4	3
199	R:R:G188	R:R:V187	1.84	No	No	0	4	3
200	R:R:G188	R:R:G189	2.11	No	No	0	4	3
201	R:R:Q191	R:R:Y293	5.64	No	Yes	0	1	4
202	R:R:A192	R:R:P193	1.87	No	Yes	1	4	3
203	L:L:?1	R:R:A192	2.78	Yes	No	1	0	4
204	R:R:F286	R:R:P193	2.89	No	Yes	0	2	3
205	R:R:L194	R:R:V199	2.98	Yes	No	0	4	5
206	R:R:C202	R:R:L194	4.76	No	Yes	0	5	4
207	R:R:N195	R:R:N197	2.72	No	No	0	4	4
208	R:R:N195	R:R:W198	6.78	No	No	0	4	6
209	R:R:L201	R:R:W198	3.42	No	No	1	5	6
210	R:R:A282	R:R:V199	5.09	No	No	0	4	5
211	R:R:V199	R:R:Y283	2.52	No	No	0	5	4
212	R:R:F203	R:R:I275	2.51	Yes	Yes	0	6	7
213	R:R:F203	R:R:V279	5.24	Yes	No	0	6	6
214	R:R:F206	R:R:F207	2.14	Yes	No	0	8	4
215	R:R:F206	R:R:T210	6.49	Yes	No	0	8	6
216	R:R:F206	R:R:W271	11.02	Yes	Yes	1	8	8
217	R:R:F206	R:R:I275	12.56	Yes	Yes	1	8	7
218	R:R:F207	R:R:V211	3.93	No	No	0	4	3
219	R:R:L208	R:R:P209	3.28	No	Yes	0	5	9
220	R:R:F267	R:R:T210	5.19	Yes	No	0	9	6
221	R:R:L216	R:R:V212	2.98	Yes	No	0	6	6
222	R:R:M213	R:R:Y217	2.39	No	Yes	3	8	9
223	R:R:M213	R:R:M264	2.89	No	No	3	8	8
224	R:R:F215	R:R:R219	17.1	No	No	0	5	4
225	R:R:I220	R:R:Y217	2.42	Yes	Yes	0	9	9
226	R:R:L260	R:R:Y217	7.03	No	Yes	0	7	9
227	R:R:M264	R:R:Y217	4.79	No	Yes	3	8	9
228	R:R:A257	R:R:F221	4.16	No	Yes	0	7	5
229	R:R:A224	R:R:A256	1.79	No	No	0	8	8
230	R:R:K225	R:R:R229	4.95	No	No	0	5	4
231	R:R:E253	R:R:K225	16.2	No	No	0	7	5
232	R:R:K230	R:R:Y226	10.75	No	No	0	3	5
233	R:R:A228	R:R:R252	2.77	No	No	0	4	6
234	R:R:E232	R:R:I231	4.1	Yes	No	0	4	7
235	R:R:E232	R:R:R248	13.96	Yes	No	0	4	3
236	R:R:E232	R:R:V249	2.85	Yes	No	0	4	4
237	R:R:E232	R:R:R252	4.65	Yes	No	0	4	6
238	R:R:E247	R:R:Y245	26.93	No	No	0	4	3
239	R:R:R248	R:R:Y245	4.12	No	No	0	3	3
240	R:R:E247	R:R:K246	2.7	No	Yes	0	4	5
241	R:R:K246	R:R:V249	3.04	Yes	No	7	5	4
242	R:R:E253	R:R:K246	4.05	No	Yes	7	7	5
243	R:R:K251	R:R:R248	12.38	No	No	0	5	3
244	R:R:E253	R:R:V249	4.28	No	No	7	7	4
245	R:R:A250	R:R:R254	2.77	No	No	0	1	4
246	R:R:I262	R:R:K258	5.82	No	No	0	6	7
247	R:R:F314	R:R:T259	2.59	No	No	0	7	8
248	R:R:I262	R:R:I310	2.94	No	No	0	6	8
249	R:R:F267	R:R:L268	3.65	Yes	No	0	9	6
250	R:R:F267	R:R:W271	8.02	Yes	Yes	0	9	8
251	R:R:C299	R:R:S270	3.44	No	No	0	7	8
252	R:R:N303	R:R:S270	4.47	No	No	0	9	8
253	R:R:I275	R:R:W271	4.7	Yes	Yes	1	7	8
254	R:R:V300	R:R:W271	9.81	No	Yes	1	7	8
255	R:R:N303	R:R:W271	3.39	No	Yes	0	9	8
256	R:R:L272	R:R:P273	3.28	No	No	0	6	9
257	R:R:I276	R:R:L272	4.28	No	No	0	6	6
258	R:R:C299	R:R:P273	5.65	No	No	0	7	9
259	R:R:I275	R:R:Y274	3.63	Yes	Yes	1	7	6
260	R:R:A278	R:R:Y274	4	No	Yes	0	5	6
261	R:R:Y274	R:R:Y293	1.99	Yes	Yes	0	6	4
262	R:R:V300	R:R:Y274	3.79	No	Yes	1	7	6
263	L:L:?1	R:R:Y274	14.48	Yes	Yes	1	0	6
264	R:R:D277	R:R:D281	2.66	No	Yes	8	5	3
265	R:R:D277	R:R:T288	4.34	No	No	8	5	6
266	R:R:D277	R:R:L296	5.43	No	No	0	5	5
267	R:R:D281	R:R:I280	2.8	Yes	No	0	3	4
268	R:R:D281	R:R:T288	10.12	Yes	No	8	3	6
269	R:R:I287	R:R:M284	7.29	No	No	0	3	3
270	R:R:P289	R:R:T288	3.5	No	No	0	4	6
271	R:R:P289	R:R:Y291	9.74	No	No	0	4	2
272	R:R:P289	R:R:V292	5.3	No	No	0	4	5
273	R:R:E294	R:R:Y293	3.37	No	Yes	0	4	4
274	R:R:V297	R:R:Y293	5.05	No	Yes	0	6	4
275	R:R:V297	R:R:Y301	8.83	No	Yes	1	6	8
276	L:L:?1	R:R:V297	9.2	Yes	No	1	0	6
277	R:R:W298	R:R:Y301	8.68	Yes	Yes	1	5	8
278	L:L:?1	R:R:V300	6.57	Yes	No	1	0	7
279	L:L:?1	R:R:Y301	5.17	Yes	Yes	1	0	8
280	R:R:A305	R:R:Y302	2.67	Yes	No	4	7	6
281	R:R:N303	R:R:N307	2.72	No	Yes	0	9	9
282	R:R:N307	R:R:Y311	6.98	Yes	Yes	1	9	9
283	R:R:I310	R:R:Y311	4.84	No	Yes	0	8	9
284	R:R:A312	R:R:F318	4.16	No	Yes	0	7	9
285	R:R:F313	R:R:I322	12.56	No	No	0	5	7
286	R:R:F314	R:R:Y315	2.06	No	Yes	0	7	8
287	R:R:P316	R:R:Y315	4.17	No	Yes	5	4	8
288	R:R:W317	R:R:Y315	17.36	No	Yes	5	6	8
289	R:R:P316	R:R:W317	9.46	No	No	5	4	6
290	R:R:F318	R:R:W317	7.02	Yes	No	0	9	6
291	R:R:K320	R:R:K323	7.18	No	No	0	5	6
292	R:R:K320	R:R:L324	7.05	No	No	0	5	4
293	R:R:G328	R:R:S327	3.71	No	No	0	4	6
294	R:R:K329	R:R:S327	3.06	No	No	0	6	6
295	R:R:G261	R:R:M264	1.75	No	No	0	5	8
296	R:R:C97	R:R:S96	1.72	No	No	0	4	3
297	R:R:G40	R:R:L39	1.71	No	Yes	0	4	7
298	R:R:G49	R:R:L52	1.71	No	No	0	8	7
299	R:R:A77	R:R:S119	1.71	No	No	0	8	9
300	R:R:G171	R:R:N173	1.7	No	Yes	0	1	4
301	R:R:A172	R:R:T170	1.68	No	No	0	6	5
302	R:R:E102	R:R:G101	1.64	No	No	0	3	8
303	R:R:E232	R:R:G233	1.64	Yes	No	0	4	5
304	R:R:A56	R:R:I322	1.62	No	No	0	7	7
305	R:R:A266	R:R:I310	1.62	No	No	0	7	8
306	R:R:S270	R:R:V269	1.62	No	No	0	8	5
307	R:R:A43	R:R:M86	1.61	No	Yes	0	6	7
308	R:R:A250	R:R:K246	1.61	No	Yes	0	1	5
309	R:R:A266	R:R:M306	1.61	No	No	0	7	5
310	R:R:T210	R:R:V214	1.59	No	No	0	6	5
311	R:R:A305	R:R:L45	1.58	Yes	No	0	7	4
312	R:R:I34	R:R:V38	1.54	No	No	0	5	5
313	R:R:I57	R:R:V71	1.54	No	No	0	7	8
314	R:R:I126	R:R:V71	1.54	No	No	0	9	8
315	R:R:A172	R:R:E175	1.51	No	No	0	6	2
316	R:R:F221	R:R:G218	1.51	Yes	No	0	5	3
317	R:R:L52	R:R:V326	1.49	No	No	0	7	5
318	R:R:G37	R:R:Y36	1.45	No	Yes	0	4	5
319	R:R:I295	R:R:L35	1.43	No	No	0	5	5
320	R:R:G101	R:R:W98	1.41	No	Yes	0	8	8
321	R:R:G188	R:R:W98	1.41	No	Yes	0	4	8
322	R:R:E178	R:R:T185	1.41	No	No	0	4	2
323	R:R:K329	R:R:L324	1.41	No	No	0	6	4
324	R:R:C110	R:R:F168	1.4	No	Yes	0	6	5
325	R:R:D281	R:R:I287	1.4	Yes	No	0	3	3
326	R:R:C190	R:R:R92	1.39	No	Yes	0	9	5
327	R:R:L309	R:R:L45	1.38	No	No	0	6	4
328	R:R:L63	R:R:Q62	1.33	No	No	0	8	6
329	R:R:A263	R:R:Y311	1.33	No	Yes	0	8	9
330	R:R:F165	R:R:S166	1.32	No	No	0	4	6
331	R:R:N195	R:R:Q196	1.32	No	No	0	4	2
332	R:R:F159	R:R:T162	1.3	No	No	0	4	4
333	R:R:S25	R:R:Y27	1.27	No	No	0	5	1
334	R:R:E174	R:R:E178	1.27	Yes	No	0	4	4
335	R:R:F79	R:R:L51	1.22	Yes	No	0	7	4
336	R:R:F159	R:R:L155	1.22	No	No	0	4	2
337	R:R:F203	R:R:L200	1.22	Yes	No	0	6	5
338	R:R:F203	R:R:L204	1.22	Yes	No	0	6	4
339	R:R:F221	R:R:L222	1.22	Yes	No	0	5	3
340	R:R:F221	R:R:L260	1.22	Yes	No	0	5	7
341	R:R:L41	R:R:Y302	1.17	No	No	0	4	6
342	R:R:W98	R:R:Y104	0.96	Yes	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y36	4.95	4	1	5
2	R:R:L39	6.7875	4	1	7
3	R:R:N50	5.8675	4	0	9
4	R:R:F60	3.7125	4	0	5
5	R:R:S73	6.6275	4	1	9
6	R:R:F79	4.16	4	0	7
7	R:R:V81	4.2325	4	1	7
8	R:R:G82	3.1775	4	1	7
9	R:R:V85	5.422	5	1	7
10	R:R:M86	4.18857	7	1	7
11	R:R:S89	5.005	4	1	6
12	R:R:R92	4.53	4	1	5
13	R:R:W98	3.42429	7	1	8
14	R:R:H108	4.538	5	1	5
15	R:R:D112	8.335	4	1	6
16	R:R:T113	6.404	5	1	4
17	R:R:S114	3.95	5	1	5
18	R:R:F115	4.922	5	1	7
19	R:R:F117	3.95	5	1	5
20	R:R:L120	4.2925	4	1	7
21	R:R:F121	3.218	5	1	5
22	R:R:H122	6.832	5	1	8
23	R:R:Y131	11.675	4	0	8
24	R:R:Y140	5.08167	6	2	7
25	R:R:F144	8.9125	4	2	6
26	R:R:I153	4.7325	4	1	8
27	R:R:W157	3.11111	9	1	9
28	R:R:Y163	5.5	6	1	5
29	R:R:I167	5.22	4	1	5
30	R:R:F168	5.39375	8	1	5
31	R:R:Y169	5.2975	4	0	5
32	R:R:N173	4.5825	4	1	4
33	R:R:E174	5.525	4	1	4
34	R:R:P193	4.815	4	1	3
35	R:R:L194	4.1825	4	1	4
36	R:R:F203	2.5475	4	0	6
37	R:R:F206	8.0525	4	1	8
38	R:R:P209	5.3075	4	1	9
39	R:R:L216	6.9775	4	0	6
40	R:R:Y217	4.852	5	3	9
41	R:R:I220	3.2925	4	0	9
42	R:R:F221	2.0275	4	0	5
43	R:R:E232	5.44	5	0	4
44	R:R:K246	2.85	4	7	5
45	R:R:F267	4.825	4	0	9
46	R:R:W271	5.93571	7	1	8
47	R:R:Y274	5.578	5	1	6
48	R:R:I275	5.85	4	1	7
49	R:R:D281	4.245	4	8	3
50	R:R:Y293	4.0125	4	0	4
51	R:R:W298	6.56833	6	1	5
52	R:R:Y301	7.72286	7	1	8
53	R:R:A305	1.9975	4	4	7
54	R:R:N307	6.048	5	1	9
55	R:R:Y311	5.004	5	1	9
56	R:R:Y315	6.67	4	5	8
57	R:R:F318	4.694	5	0	9
58	L:L:?1	7.73444	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C186	R:R:C22	49.3683	7.28	No	No	0	3	8
2	R:R:C22	R:R:V187	51.8772	5.12	No	No	0	8	3
3	R:R:A183	R:R:C186	46.8504	1.81	No	No	0	2	3
4	R:R:A183	R:R:K24	44.3235	3.21	No	No	0	2	5
5	R:R:K24	R:R:S96	41.7876	3.06	No	No	0	5	3
6	R:R:S96	R:R:Y27	31.5547	3.82	No	No	0	3	1
7	R:R:Y27	R:R:Y291	26.3844	9.93	No	No	0	1	2
8	R:R:G188	R:R:V187	54.3772	1.84	No	No	0	4	3
9	R:R:G188	R:R:W98	59.3504	1.41	No	Yes	0	4	8
10	R:R:H108	R:R:W98	66.9713	3.17	Yes	Yes	1	5	8
11	R:R:H108	R:R:S89	37.5	4.18	Yes	Yes	1	5	6
12	R:R:S89	R:R:W298	16.3754	3.71	Yes	Yes	1	6	5
13	R:R:H108	R:R:V85	45.1927	9.69	Yes	Yes	1	5	7
14	R:R:V85	R:R:Y301	23.7858	5.05	Yes	Yes	1	7	8
15	R:R:M86	R:R:Y301	40.7168	4.79	Yes	Yes	1	7	8
16	R:R:G82	R:R:M86	16.5143	5.24	Yes	Yes	1	7	7
17	R:R:A46	R:R:G82	13.7948	1.95	No	Yes	0	7	7
18	R:R:A305	R:R:A46	11.8504	1.79	Yes	No	0	7	7
19	R:R:S89	R:R:Y301	23.2079	8.9	Yes	Yes	1	6	8
20	R:R:M86	R:R:W298	23.7455	3.49	Yes	Yes	1	7	5
21	R:R:D78	R:R:S304	50.3181	8.83	No	No	0	9	9
22	R:R:M86	R:R:S304	46.5099	3.07	Yes	No	1	7	9
23	R:R:D78	R:R:N307	52.9391	2.69	No	Yes	0	9	9
24	R:R:N307	R:R:Y311	100	6.98	Yes	Yes	1	9	9
25	R:R:I126	R:R:Y311	98.172	4.84	No	Yes	0	9	9
26	R:R:I126	R:R:V71	96.8996	1.54	No	No	0	9	8
27	R:R:I57	R:R:V71	95.4794	1.54	No	No	0	7	8
28	R:R:F318	R:R:I57	92.7912	5.02	Yes	No	0	9	7
29	R:R:A312	R:R:F318	37.3656	4.16	No	Yes	0	7	9
30	R:R:A312	R:R:V53	35.4794	3.39	No	No	0	7	9
31	R:R:F313	R:R:V53	33.5842	3.93	No	No	0	5	9
32	R:R:F313	R:R:I322	31.6801	12.56	No	No	0	5	7
33	R:R:A56	R:R:I322	23.974	1.62	No	No	0	7	7
34	R:R:A321	R:R:A56	22.0251	1.79	No	No	0	7	7
35	R:R:A321	R:R:F60	20.0582	4.16	No	Yes	0	7	5
36	R:R:F60	R:R:L324	12.1371	3.65	Yes	No	0	5	4
37	R:R:F115	R:R:W157	14.328	4.01	Yes	Yes	1	7	9
38	R:R:I153	R:R:W157	16.1111	2.35	Yes	Yes	1	8	9
39	R:R:G150	R:R:I153	20.6989	1.76	No	Yes	0	4	8
40	R:R:G150	R:R:S149	19.9014	1.86	No	No	0	4	7
41	R:R:F69	R:R:S149	19.1174	2.64	No	No	0	5	7
42	R:R:F69	R:R:V146	16.7518	3.93	No	No	0	5	3
43	R:R:P66	R:R:V146	15.9857	3.53	No	No	0	6	3
44	R:R:P66	R:R:T65	15.3987	3.5	No	No	0	6	8
45	R:R:T65	R:R:T67	24.2697	4.71	No	No	0	8	8
46	R:R:F318	R:R:N68	16.1873	4.83	Yes	No	0	9	9
47	R:R:T67	R:R:Y140	13.6738	2.5	No	Yes	2	8	7
48	R:R:H122	R:R:W157	10.1075	4.23	Yes	Yes	1	8	9
49	R:R:H122	R:R:L74	17.6478	6.43	Yes	No	1	8	9
50	R:R:L74	R:R:N307	11.3844	9.61	No	Yes	1	9	9
51	R:R:D112	R:R:V85	18.4633	4.38	Yes	Yes	1	6	7
52	R:R:E294	R:R:R92	11.4158	10.47	No	Yes	0	4	5
53	R:R:D112	R:R:T113	11.9713	4.34	Yes	Yes	1	6	4
54	R:R:F168	R:R:T113	12.397	10.38	Yes	Yes	1	5	4
55	R:R:C110	R:R:F168	13.1676	1.4	No	Yes	0	6	5
56	R:R:C110	R:R:Y169	10.9946	4.03	No	Yes	0	6	5
57	L:L:?1	R:R:F168	33.6873	7.52	Yes	Yes	1	0	5
58	L:L:?1	R:R:Y301	32.7688	5.17	Yes	Yes	1	0	8
59	R:R:T113	R:R:Y163	14.1801	4.99	Yes	Yes	1	4	5
60	R:R:S164	R:R:T113	13.6111	3.2	No	Yes	0	7	4
61	R:R:S114	R:R:S164	13.4588	4.89	Yes	No	0	5	7
62	L:L:?1	R:R:C116	23.5708	2.8	Yes	No	0	0	7
63	R:R:E294	R:R:Y293	11.8414	3.37	No	Yes	0	4	4
64	R:R:Y274	R:R:Y293	13.9113	1.99	Yes	Yes	0	6	4
65	R:R:I275	R:R:Y274	12.3253	3.63	Yes	Yes	1	7	6
66	R:R:V300	R:R:W271	29.3324	9.81	No	Yes	1	7	8
67	L:L:?1	R:R:V300	23.4543	6.57	Yes	No	1	0	7
68	R:R:C116	R:R:W271	23.2258	2.61	No	Yes	0	7	8
69	R:R:F117	R:R:Y163	20.4525	7.22	Yes	Yes	1	5	5
70	R:R:F117	R:R:F121	16.5188	3.22	Yes	Yes	1	5	5
71	R:R:F267	R:R:W271	10.4704	8.02	Yes	Yes	0	9	8
72	R:R:H122	R:R:S156	12.0206	9.76	Yes	No	0	8	7
73	R:R:F121	R:R:S156	11.828	3.96	Yes	No	0	5	7
74	R:R:F121	R:R:F159	11.6219	2.14	Yes	No	0	5	4
75	R:R:F318	R:R:W317	49.8253	7.02	Yes	No	0	9	6
76	R:R:W317	R:R:Y315	46.0618	17.36	No	Yes	5	6	8
77	R:R:R130	R:R:Y315	40.7482	3.09	No	Yes	0	9	8
78	R:R:I220	R:R:R130	38.8979	2.51	Yes	No	0	9	9
79	R:R:I220	R:R:Y217	19.7222	2.42	Yes	Yes	0	9	9
80	R:R:I220	R:R:Y131	13.9875	3.63	Yes	Yes	0	9	8
81	R:R:F168	R:R:N173	16.7339	7.25	Yes	Yes	1	5	4
82	L:L:?1	R:R:A192	15.9319	2.78	Yes	No	1	0	4
83	R:R:A192	R:R:P193	16.7966	1.87	No	Yes	1	4	3
84	R:R:N195	R:R:W198	10.3315	6.78	No	No	0	4	6
85	R:R:I310	R:R:Y311	10.1165	4.84	No	Yes	0	8	9
86	R:R:N303	R:R:W271	61.8862	3.39	No	Yes	0	9	8
87	R:R:N303	R:R:S270	15.8557	4.47	No	No	0	9	8
88	R:R:C299	R:R:S270	10.6048	3.44	No	No	0	7	8
89	R:R:P289	R:R:Y291	23.7858	9.74	No	No	0	4	2
90	R:R:P289	R:R:T288	18.5618	3.5	No	No	0	4	6
91	R:R:D281	R:R:T288	10.6228	10.12	Yes	No	8	3	6
92	R:R:N68	R:R:T65	14.664	7.31	No	No	0	9	8
93	R:R:F117	R:R:W271	19.7849	2	Yes	Yes	1	5	8
94	R:R:N303	R:R:N307	52.6971	2.72	No	Yes	0	9	9
95	R:R:S114	R:R:W157	11.6532	2.47	Yes	Yes	1	5	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S89	R:R:V85	3.23	1	Yes	Yes	6	7	2	2
R:R:D112	R:R:V85	4.38	1	Yes	Yes	6	7	1	2
R:R:V85	R:R:Y301	5.05	1	Yes	Yes	7	8	2	1
R:R:M86	R:R:W298	3.49	1	Yes	Yes	7	5	2	2
R:R:M86	R:R:Y301	4.79	1	Yes	Yes	7	8	2	1
R:R:S89	R:R:W298	3.71	1	Yes	Yes	6	5	2	2
R:R:S89	R:R:Y301	8.9	1	Yes	Yes	6	8	2	1
R:R:F168	R:R:T109	5.19	1	Yes	No	5	5	1	2
R:R:D112	R:R:T113	4.34	1	Yes	Yes	6	4	1	1
R:R:D112	R:R:Y301	12.64	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:D112	11.98	1	Yes	Yes	0	6	0	1
R:R:T113	R:R:Y163	4.99	1	Yes	Yes	4	5	1	2
R:R:S164	R:R:T113	3.2	0	No	Yes	7	4	2	1
R:R:F168	R:R:T113	10.38	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:T113	9.11	1	Yes	Yes	0	4	0	1
R:R:C116	R:R:W271	2.61	0	No	Yes	7	8	1	2
L:L:?1	R:R:C116	2.8	1	Yes	No	0	7	0	1
R:R:I167	R:R:Y163	6.04	1	Yes	Yes	5	5	2	2
R:R:F168	R:R:I167	3.77	1	Yes	Yes	5	5	1	2
R:R:F168	R:R:N173	7.25	1	Yes	Yes	5	4	1	2
R:R:A192	R:R:F168	2.77	1	No	Yes	4	5	1	1
R:R:F168	R:R:L194	4.87	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:F168	7.52	1	Yes	Yes	0	5	0	1
R:R:L194	R:R:N173	4.12	1	Yes	Yes	4	4	2	2
R:R:A192	R:R:P193	1.87	1	No	Yes	4	3	1	2
L:L:?1	R:R:A192	2.78	1	Yes	No	0	4	0	1
R:R:I275	R:R:W271	4.7	1	Yes	Yes	7	8	2	2
R:R:V300	R:R:W271	9.81	1	No	Yes	7	8	1	2
R:R:I275	R:R:Y274	3.63	1	Yes	Yes	7	6	2	1
R:R:A278	R:R:Y274	4	0	No	Yes	5	6	2	1
R:R:Y274	R:R:Y293	1.99	1	Yes	Yes	6	4	1	2
R:R:V300	R:R:Y274	3.79	1	No	Yes	7	6	1	1
L:L:?1	R:R:Y274	14.48	1	Yes	Yes	0	6	0	1
R:R:V297	R:R:Y293	5.05	1	No	Yes	6	4	1	2
R:R:V297	R:R:Y301	8.83	1	No	Yes	6	8	1	1
L:L:?1	R:R:V297	9.2	1	Yes	No	0	6	0	1
R:R:W298	R:R:Y301	8.68	1	Yes	Yes	5	8	2	1
L:L:?1	R:R:V300	6.57	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y301	5.17	1	Yes	Yes	0	8	0	1
R:R:C110	R:R:F168	1.4	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IW4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.76
Number of Linked Nodes	285
Number of Links	342
Number of Hubs	58
Number of Links mediated by Hubs	214
Number of Communities	8
Number of Nodes involved in Communities	79
Number of Links involved in Communities	119

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	62690
Length Of Smallest Path	3
Average Path Length	13.6335
Length of Longest Path	38
Minimum Path Strength	1.185
Average Path Strength	4.76933
Maximum Path Strength	16.905
Minimum Path Correlation	0.7
Average Path Correlation	0.932708
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	53.1468
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.785
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SPD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SPD
Name	Spermidine
Synonyms	4-azaoctane-1,8-diamine
Identifier
Formula	C7 H19 N3
Molecular Weight	145.246
SMILES
PubChem	1102
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	0
Total Bonds	28
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD04
Sequence	>8IW4_nogp_Chain_R C I K S S Y A P W P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F K Q L H T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S C W Y F G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D P L T Y P T K F T V S V S G L C I A L S W F F S V T Y S F S I F Y T G A N E E G I E E L V A L T C V G G C Q A P L N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G Y K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M N F I T P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W F R K A I K L I V S G K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ITF	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-	chim(NtGi1-Gs)/β1/γ2	3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8ITF (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-		3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	chim(NtGi1-Gs)/β1/γ2	3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-		3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-		2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWE	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	-	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWM	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	-	3.17	2023-05-31	doi.org/10.1038/s41586-023-06106-4

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