psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C22	R:R:I23	3.27	No	No	0	8	2
2	R:R:C186	R:R:C22	7.28	No	No	0	3	8
3	R:R:C97	R:R:I23	3.27	No	No	0	4	2
4	R:R:S26	R:R:S96	3.26	No	No	0	3	3
5	R:R:C97	R:R:S26	6.89	No	No	0	4	3
6	R:R:P29	R:R:W30	2.7	No	No	0	3	1
7	R:R:L35	R:R:L39	4.15	No	No	0	5	7
8	R:R:T90	R:R:Y36	3.75	No	Yes	0	6	5
9	R:R:V94	R:R:Y36	11.36	No	Yes	0	6	5
10	R:R:L39	R:R:W298	11.39	No	Yes	0	7	5
11	R:R:L41	R:R:L45	2.77	No	No	0	4	4
12	R:R:G42	R:R:Y302	4.35	No	No	0	6	6
13	R:R:A43	R:R:M86	3.22	No	Yes	0	6	7
14	R:R:L309	R:R:L45	2.77	No	No	0	6	4
15	R:R:F48	R:R:V47	2.62	No	No	0	4	6
16	R:R:F79	R:R:V47	3.93	No	No	0	7	6
17	R:R:A75	R:R:N50	4.69	No	Yes	0	9	9
18	R:R:D78	R:R:N50	14.81	No	Yes	7	9	9
19	R:R:N50	R:R:P308	13.03	Yes	No	7	9	9
20	R:R:I322	R:R:L52	5.71	No	No	0	7	7
21	R:R:I57	R:R:V53	3.07	Yes	No	0	7	9
22	R:R:A75	R:R:V53	3.39	No	No	0	9	9
23	R:R:I54	R:R:L58	2.85	No	No	0	8	4
24	R:R:A75	R:R:I54	3.25	No	No	0	9	8
25	R:R:I325	R:R:I55	2.94	No	No	0	6	4
26	R:R:I57	R:R:L63	4.28	Yes	No	4	7	8
27	R:R:I57	R:R:N68	2.83	Yes	Yes	4	7	9
28	R:R:A72	R:R:I57	3.25	No	Yes	0	6	7
29	R:R:F318	R:R:I57	5.02	Yes	Yes	4	9	7
30	R:R:F60	R:R:H59	6.79	Yes	No	8	5	6
31	R:R:H59	R:R:V330	8.3	No	No	0	6	6
32	R:R:D334	R:R:H59	12.61	No	No	8	4	6
33	R:R:A321	R:R:F60	4.16	No	Yes	0	7	5
34	R:R:F60	R:R:L324	4.87	Yes	No	0	5	4
35	R:R:D334	R:R:F60	10.75	No	Yes	8	4	5
36	R:R:H64	R:R:K61	5.24	No	No	0	7	6
37	R:R:Q62	R:R:T337	9.92	No	No	0	6	4
38	R:R:L63	R:R:N68	5.49	No	Yes	4	8	9
39	R:R:P66	R:R:T65	5.25	No	No	0	6	8
40	R:R:N68	R:R:T65	5.85	Yes	No	0	9	8
41	R:R:P66	R:R:V146	3.53	No	No	0	6	3
42	R:R:P66	R:R:S149	3.56	No	No	0	6	7
43	R:R:D129	R:R:T67	10.12	No	No	5	9	8
44	R:R:T67	R:R:Y140	3.75	No	Yes	5	8	7
45	R:R:F318	R:R:N68	4.83	Yes	Yes	4	9	9
46	R:R:C125	R:R:L70	3.17	No	No	0	6	8
47	R:R:I126	R:R:L70	2.85	No	No	0	9	8
48	R:R:H122	R:R:S73	5.58	Yes	No	0	8	9
49	R:R:I153	R:R:S73	10.84	No	No	0	8	9
50	R:R:L74	R:R:S119	3	No	No	0	9	9
51	R:R:H122	R:R:L74	6.43	Yes	No	0	8	9
52	R:R:L74	R:R:N307	12.36	No	No	0	9	9
53	R:R:A77	R:R:W157	3.89	No	Yes	0	8	9
54	R:R:D78	R:R:S304	5.89	No	No	0	9	9
55	R:R:D78	R:R:P308	6.44	No	No	7	9	9
56	R:R:F79	R:R:V83	6.55	No	No	0	7	4
57	R:R:F115	R:R:L80	4.87	Yes	No	0	7	7
58	R:R:G82	R:R:V81	5.52	No	No	0	7	7
59	R:R:V81	R:R:V85	3.21	No	Yes	0	7	7
60	R:R:F115	R:R:V81	7.87	Yes	No	0	7	7
61	R:R:G82	R:R:M86	5.24	No	Yes	0	7	7
62	R:R:T84	R:R:V85	3.17	No	Yes	0	5	7
63	R:R:S89	R:R:V85	3.23	Yes	Yes	2	6	7
64	R:R:H108	R:R:V85	5.54	No	Yes	2	5	7
65	R:R:V85	R:R:Y301	5.05	Yes	Yes	2	7	8
66	R:R:M86	R:R:W298	9.31	Yes	Yes	0	7	5
67	R:R:F100	R:R:F88	9.65	No	No	0	6	5
68	R:R:F88	R:R:Y104	8.25	No	No	0	5	6
69	R:R:F88	R:R:H108	5.66	No	No	0	5	5
70	R:R:H108	R:R:S89	2.79	No	Yes	2	5	6
71	R:R:S89	R:R:W298	3.71	Yes	Yes	2	6	5
72	R:R:S89	R:R:Y301	7.63	Yes	Yes	2	6	8
73	R:R:T90	R:R:W298	4.85	No	Yes	0	6	5
74	R:R:F100	R:R:V91	6.55	No	No	0	6	4
75	R:R:E294	R:R:R92	8.14	No	No	0	4	5
76	R:R:E294	R:R:S93	5.75	No	No	0	4	4
77	R:R:S93	R:R:W298	4.94	No	Yes	0	4	5
78	R:R:E95	R:R:V94	7.13	No	No	0	5	6
79	R:R:F100	R:R:W98	5.01	No	No	0	6	8
80	R:R:C105	R:R:W98	2.61	No	No	0	9	8
81	R:R:C190	R:R:W98	11.75	No	No	0	9	8
82	R:R:C105	R:R:E102	3.04	No	No	0	9	3
83	R:R:F107	R:R:K106	11.17	No	No	0	5	6
84	R:R:K106	R:R:Y169	7.17	No	No	0	6	5
85	R:R:F168	R:R:T109	5.19	Yes	No	1	5	5
86	R:R:A192	R:R:T109	3.36	No	No	1	4	5
87	R:R:C110	R:R:S164	3.44	No	No	0	6	7
88	R:R:C110	R:R:Y169	4.03	No	No	0	6	5
89	R:R:F111	R:R:F115	5.36	No	Yes	0	5	7
90	R:R:D112	R:R:Y301	11.49	No	Yes	0	6	8
91	R:R:T113	R:R:Y163	3.75	No	Yes	1	4	5
92	R:R:S164	R:R:T113	6.4	No	No	0	7	4
93	R:R:F168	R:R:T113	10.38	Yes	No	1	5	4
94	R:R:F115	R:R:S114	2.64	Yes	No	0	7	5
95	R:R:S114	R:R:S164	6.52	No	No	0	5	7
96	R:R:F115	R:R:W157	4.01	Yes	Yes	0	7	9
97	R:R:C116	R:R:W271	2.61	No	Yes	0	7	8
98	R:R:C116	R:R:Y301	2.69	No	Yes	0	7	8
99	R:R:F117	R:R:Y163	3.09	No	Yes	0	5	5
100	R:R:F117	R:R:W271	4.01	No	Yes	0	5	8
101	R:R:A118	R:R:W157	5.19	No	Yes	0	7	9
102	R:R:A118	R:R:S160	3.42	No	No	0	7	8
103	R:R:F121	R:R:L120	4.87	Yes	Yes	3	5	7
104	R:R:L120	R:R:P209	4.93	Yes	Yes	3	7	9
105	R:R:F267	R:R:L120	4.87	Yes	Yes	3	9	7
106	R:R:L120	R:R:W271	5.69	Yes	Yes	3	7	8
107	R:R:F121	R:R:S156	3.96	Yes	No	0	5	7
108	R:R:F121	R:R:L205	3.65	Yes	No	0	5	4
109	R:R:F121	R:R:P209	2.89	Yes	Yes	3	5	9
110	R:R:H122	R:R:S156	8.37	Yes	No	0	8	7
111	R:R:H122	R:R:W157	4.23	Yes	Yes	0	8	9
112	R:R:L123	R:R:M213	4.24	No	No	0	8	8
113	R:R:L123	R:R:Y311	4.69	No	Yes	0	8	9
114	R:R:C125	R:R:C152	7.28	No	No	0	6	6
115	R:R:M213	R:R:S127	7.67	No	No	0	8	8
116	R:R:S127	R:R:Y217	3.82	No	Yes	0	8	9
117	R:R:I128	R:R:L216	2.85	No	No	0	7	6
118	R:R:D129	R:R:Y140	5.75	No	Yes	5	9	7
119	R:R:D129	R:R:F144	13.14	No	No	5	9	6
120	R:R:R130	R:R:Y315	3.09	No	No	0	9	8
121	R:R:T135	R:R:Y131	14.98	No	Yes	0	6	8
122	R:R:L216	R:R:Y131	16.41	No	Yes	0	6	8
123	R:R:R219	R:R:Y131	4.12	No	Yes	0	4	8
124	R:R:I220	R:R:Y131	3.63	No	Yes	0	9	8
125	R:R:A133	R:R:Y140	9.34	No	Yes	0	8	7
126	R:R:I220	R:R:V134	3.07	No	No	0	9	8
127	R:R:D136	R:R:T139	5.78	No	No	0	6	5
128	R:R:L138	R:R:P137	3.28	No	No	0	6	8
129	R:R:K143	R:R:T139	4.5	No	No	0	4	5
130	R:R:P141	R:R:Y140	4.17	No	Yes	0	4	7
131	R:R:F144	R:R:Y140	5.16	No	Yes	5	6	7
132	R:R:F144	R:R:V148	3.93	No	No	0	6	6
133	R:R:G150	R:R:I153	5.29	No	No	0	4	8
134	R:R:L151	R:R:L155	5.54	No	No	0	3	2
135	R:R:F158	R:R:T162	7.78	No	No	0	4	4
136	R:R:I167	R:R:Y163	6.04	No	Yes	1	5	5
137	R:R:F168	R:R:Y163	3.09	Yes	Yes	1	5	5
138	R:R:L201	R:R:Y163	3.52	No	Yes	0	5	5
139	R:R:C202	R:R:Y163	2.69	No	Yes	0	5	5
140	R:R:F165	R:R:Y169	8.25	No	No	0	4	5
141	R:R:F168	R:R:I167	5.02	Yes	No	1	5	5
142	R:R:I167	R:R:W198	8.22	No	Yes	1	5	6
143	R:R:F168	R:R:N173	6.04	Yes	No	0	5	4
144	R:R:A192	R:R:F168	2.77	No	Yes	1	4	5
145	R:R:F168	R:R:L194	6.09	Yes	No	0	5	4
146	R:R:E174	R:R:I177	4.1	No	No	0	4	1
147	R:R:E174	R:R:L184	11.93	No	No	0	4	4
148	R:R:F286	R:R:I177	7.54	No	No	0	2	1
149	R:R:E179	R:R:N285	6.57	No	No	0	3	1
150	R:R:E179	R:R:F286	3.5	No	No	0	3	2
151	R:R:L180	R:R:V182	8.94	No	Yes	9	2	2
152	R:R:L180	R:R:Q191	3.99	No	Yes	9	2	1
153	R:R:Q191	R:R:V182	2.87	Yes	Yes	9	1	2
154	R:R:P193	R:R:Q191	6.32	No	Yes	0	3	1
155	R:R:Q191	R:R:Y293	6.76	Yes	Yes	0	1	4
156	R:R:L194	R:R:W198	3.42	No	Yes	0	4	6
157	R:R:L194	R:R:V199	2.98	No	No	0	4	5
158	R:R:N195	R:R:N197	13.62	No	No	1	4	4
159	R:R:N195	R:R:W198	9.04	No	Yes	1	4	6
160	R:R:Q196	R:R:Y283	7.89	No	No	0	2	4
161	R:R:N197	R:R:W198	3.39	No	Yes	1	4	6
162	R:R:V199	R:R:V279	3.21	No	No	0	5	6
163	R:R:A282	R:R:V199	5.09	No	No	0	4	5
164	R:R:L201	R:R:L205	2.77	No	No	0	5	4
165	R:R:F203	R:R:F207	4.29	No	No	0	6	4
166	R:R:L204	R:R:L208	2.77	No	No	0	4	5
167	R:R:F206	R:R:T210	7.78	Yes	No	0	8	6
168	R:R:F206	R:R:W271	9.02	Yes	Yes	0	8	8
169	R:R:F206	R:R:I275	11.3	Yes	No	0	8	7
170	R:R:F207	R:R:V211	7.87	No	No	0	4	3
171	R:R:F267	R:R:T210	9.08	Yes	No	0	9	6
172	R:R:L216	R:R:V212	2.98	No	No	0	6	6
173	R:R:M213	R:R:M264	2.89	No	No	0	8	8
174	R:R:F215	R:R:R219	10.69	No	No	0	5	4
175	R:R:L260	R:R:Y217	3.52	No	Yes	0	7	9
176	R:R:M264	R:R:Y217	4.79	No	Yes	0	8	9
177	R:R:A257	R:R:F221	4.16	No	Yes	0	7	5
178	R:R:F221	R:R:L260	3.65	Yes	No	0	5	7
179	R:R:K225	R:R:R229	4.95	No	Yes	6	5	4
180	R:R:E253	R:R:K225	18.9	No	No	6	7	5
181	R:R:R229	R:R:Y245	4.12	Yes	No	0	4	3
182	R:R:R229	R:R:V249	6.54	Yes	No	6	4	4
183	R:R:E253	R:R:R229	4.65	No	Yes	6	7	4
184	R:R:I231	R:R:R252	6.26	No	No	0	7	6
185	R:R:E232	R:R:R248	10.47	No	No	0	4	3
186	R:R:E232	R:R:V249	2.85	No	No	0	4	4
187	R:R:E232	R:R:R252	5.82	No	No	0	4	6
188	R:R:G233	R:R:Y245	2.9	No	No	0	5	3
189	R:R:E253	R:R:V249	4.28	No	No	6	7	4
190	R:R:A250	R:R:R254	4.15	No	No	0	1	4
191	R:R:F314	R:R:T259	5.19	No	No	0	7	8
192	R:R:I262	R:R:I310	2.94	No	No	0	6	8
193	R:R:F267	R:R:L268	7.31	Yes	No	0	9	6
194	R:R:F267	R:R:W271	5.01	Yes	Yes	3	9	8
195	R:R:N303	R:R:S270	5.96	No	No	0	9	8
196	R:R:V300	R:R:W271	6.13	No	Yes	0	7	8
197	R:R:N303	R:R:W271	4.52	No	Yes	0	9	8
198	R:R:I275	R:R:Y274	3.63	No	No	0	7	6
199	R:R:Y274	R:R:Y293	3.97	No	Yes	0	6	4
200	R:R:D277	R:R:D281	3.99	Yes	No	10	5	3
201	R:R:D277	R:R:T288	7.23	Yes	No	10	5	6
202	R:R:D277	R:R:L296	5.43	Yes	No	0	5	5
203	R:R:D281	R:R:F286	8.36	No	No	0	3	2
204	R:R:D281	R:R:T288	11.56	No	No	10	3	6
205	R:R:I287	R:R:M284	2.92	No	No	0	3	3
206	R:R:P289	R:R:T288	3.5	No	No	0	4	6
207	R:R:P289	R:R:Y291	5.56	No	No	0	4	2
208	R:R:P289	R:R:V292	5.3	No	No	0	4	5
209	R:R:V297	R:R:Y293	5.05	No	Yes	0	6	4
210	R:R:V297	R:R:Y301	6.31	No	Yes	0	6	8
211	R:R:W298	R:R:Y301	11.58	Yes	Yes	2	5	8
212	R:R:N307	R:R:P308	4.89	No	No	0	9	9
213	R:R:N307	R:R:Y311	6.98	No	Yes	0	9	9
214	R:R:I310	R:R:Y311	6.04	No	Yes	0	8	9
215	R:R:A312	R:R:F318	5.55	No	Yes	0	7	9
216	R:R:F313	R:R:I322	10.05	No	No	0	5	7
217	R:R:F314	R:R:Y315	5.16	No	No	0	7	8
218	R:R:W317	R:R:Y315	15.43	Yes	No	0	6	8
219	R:R:P316	R:R:W317	2.7	No	Yes	0	4	6
220	R:R:F318	R:R:W317	8.02	Yes	Yes	0	9	6
221	R:R:K320	R:R:T338	9.01	No	No	0	5	6
222	R:R:K329	R:R:L324	2.82	No	No	0	6	4
223	R:R:L324	R:R:S336	3	No	No	0	4	5
224	R:R:I325	R:R:V330	4.61	No	No	0	6	6
225	R:R:D334	R:R:S336	2.94	No	No	0	4	5
226	R:R:I220	R:R:R130	2.51	No	No	0	9	9
227	R:R:F203	R:R:I275	2.51	No	No	0	6	7
228	R:R:F206	R:R:L272	2.44	Yes	No	0	8	6
229	R:R:T338	R:R:W317	2.43	No	Yes	0	6	6
230	R:R:F79	R:R:N50	2.42	No	Yes	0	7	9
231	R:R:I126	R:R:Y311	2.42	No	Yes	0	9	9
232	R:R:I132	R:R:Y131	2.42	No	Yes	0	5	8
233	R:R:I132	R:R:Y140	2.42	No	Yes	0	5	7
234	R:R:E247	R:R:R248	2.33	No	No	0	4	3
235	R:R:D277	R:R:Y293	2.3	Yes	Yes	0	5	4
236	R:R:E95	R:R:Y99	2.24	No	No	0	5	2
237	R:R:F121	R:R:F159	2.14	Yes	No	0	5	4
238	R:R:G188	R:R:G189	2.11	No	No	0	4	3
239	R:R:C22	R:R:G188	1.96	No	No	0	8	4
240	R:R:A305	R:R:G42	1.95	No	No	0	7	6
241	R:R:C124	R:R:P209	1.88	No	Yes	0	7	9
242	R:R:A28	R:R:P29	1.87	No	No	0	4	3
243	R:R:G328	R:R:S327	1.86	No	No	0	4	6
244	R:R:G189	R:R:V182	1.84	No	Yes	0	3	2
245	R:R:G188	R:R:V187	1.84	No	No	0	4	3
246	R:R:G328	R:R:V330	1.84	No	No	0	4	6
247	R:R:A305	R:R:A46	1.79	No	No	0	7	7
248	R:R:A321	R:R:A56	1.79	No	No	0	7	7
249	R:R:A224	R:R:A256	1.79	No	No	0	8	8
250	R:R:G40	R:R:L39	1.71	No	No	0	4	7
251	R:R:G42	R:R:L41	1.71	No	No	0	6	4
252	R:R:G49	R:R:L52	1.71	No	No	0	8	7
253	R:R:A290	R:R:V182	1.7	No	Yes	0	3	2
254	R:R:M86	R:R:P87	1.68	Yes	No	0	7	8
255	R:R:C76	R:R:I54	1.64	No	No	0	7	8
256	R:R:L208	R:R:P209	1.64	No	Yes	0	5	9
257	R:R:L272	R:R:P273	1.64	No	No	0	6	9
258	R:R:L296	R:R:P273	1.64	No	No	0	5	9
259	R:R:S114	R:R:V161	1.62	No	No	0	5	3
260	R:R:S160	R:R:V161	1.62	No	No	0	8	3
261	R:R:A266	R:R:I310	1.62	No	No	0	7	8
262	R:R:D136	R:R:P137	1.61	No	No	0	6	8
263	R:R:A266	R:R:M306	1.61	No	No	0	7	5
264	R:R:V134	R:R:V223	1.6	No	No	0	8	5
265	R:R:S147	R:R:T145	1.6	No	No	0	4	7
266	R:R:T145	R:R:V148	1.59	No	No	0	7	6
267	R:R:T210	R:R:V214	1.59	No	No	0	6	5
268	R:R:A183	R:R:L184	1.58	No	No	0	2	4
269	R:R:T139	R:R:T142	1.57	No	No	0	5	4
270	R:R:A46	R:R:N50	1.56	No	Yes	0	7	9
271	R:R:I57	R:R:V71	1.54	Yes	No	0	7	8
272	R:R:I126	R:R:V71	1.54	No	No	0	9	8
273	R:R:I280	R:R:V279	1.54	No	No	0	4	6
274	R:R:K24	R:R:S25	1.53	No	No	0	5	5
275	R:R:K106	R:R:S103	1.53	No	No	0	6	2
276	R:R:F48	R:R:G49	1.51	No	No	0	4	8
277	R:R:A172	R:R:E175	1.51	No	No	0	6	2
278	R:R:F221	R:R:G218	1.51	Yes	No	0	5	3
279	R:R:L35	R:R:V38	1.49	No	No	0	5	5
280	R:R:I276	R:R:I280	1.47	No	No	0	6	4
281	R:R:G37	R:R:Y36	1.45	No	Yes	0	4	5
282	R:R:D136	R:R:T135	1.45	No	No	0	6	6
283	R:R:P316	R:R:R319	1.44	No	No	0	4	8
284	R:R:I34	R:R:L35	1.43	No	No	0	5	5
285	R:R:I55	R:R:L51	1.43	No	No	0	4	4
286	R:R:A228	R:R:R252	1.38	No	No	0	4	6
287	R:R:K230	R:R:Q227	1.36	No	No	0	3	6
288	R:R:P31	R:R:W30	1.35	No	No	0	3	1
289	R:R:A33	R:R:Y36	1.33	No	Yes	0	5	5
290	R:R:L63	R:R:Q62	1.33	No	No	0	8	6
291	R:R:A263	R:R:Y217	1.33	No	Yes	0	8	9
292	R:R:F69	R:R:S149	1.32	No	No	0	5	7
293	R:R:E175	R:R:N195	1.31	No	No	0	2	4
294	R:R:S244	R:R:Y245	1.27	No	No	0	3	3
295	R:R:F221	R:R:K225	1.24	Yes	No	0	5	5
296	R:R:F69	R:R:H64	1.13	No	No	0	5	7
297	R:R:F158	R:R:F159	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y36	4.4725	4	0	5
2	R:R:N50	7.302	5	7	9
3	R:R:I57	3.33167	6	4	7
4	R:R:F60	6.6425	4	8	5
5	R:R:N68	4.75	4	4	9
6	R:R:V85	4.04	5	2	7
7	R:R:M86	4.8625	4	0	7
8	R:R:S89	4.34	4	2	6
9	R:R:F115	4.95	5	0	7
10	R:R:L120	5.09	4	3	7
11	R:R:F121	3.502	5	3	5
12	R:R:H122	6.1525	4	0	8
13	R:R:Y131	8.312	5	0	8
14	R:R:Y140	5.09833	6	5	7
15	R:R:W157	4.33	4	0	9
16	R:R:Y163	3.69667	6	1	5
17	R:R:F168	5.51143	7	1	5
18	R:R:V182	3.8375	4	9	2
19	R:R:Q191	4.985	4	9	1
20	R:R:W198	6.0175	4	1	6
21	R:R:F206	7.635	4	0	8
22	R:R:P209	2.835	4	3	9
23	R:R:Y217	3.365	4	0	9
24	R:R:F221	2.64	4	0	5
25	R:R:R229	5.065	4	6	4
26	R:R:F267	6.5675	4	3	9
27	R:R:W271	5.28429	7	3	8
28	R:R:D277	4.7375	4	10	5
29	R:R:Y293	4.52	4	0	4
30	R:R:W298	7.63	6	2	5
31	R:R:Y301	7.45833	6	2	8
32	R:R:Y311	5.0325	4	0	9
33	R:R:W317	7.145	4	0	6
34	R:R:F318	5.855	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G188	R:R:G189	10.1671	2.11	No	No	0	4	3
2	R:R:G189	R:R:V182	11.4029	1.84	No	Yes	0	3	2
3	R:R:Q191	R:R:V182	13.807	2.87	Yes	Yes	9	1	2
4	R:R:Q191	R:R:Y293	17.3004	6.76	Yes	Yes	0	1	4
5	R:R:V297	R:R:Y293	28.8379	5.05	No	Yes	0	6	4
6	R:R:V297	R:R:Y301	29.6974	6.31	No	Yes	0	6	8
7	R:R:W298	R:R:Y301	17.3638	11.58	Yes	Yes	2	5	8
8	R:R:L39	R:R:W298	12.1158	11.39	No	Yes	0	7	5
9	R:R:T90	R:R:W298	16.8766	4.85	No	Yes	0	6	5
10	R:R:T90	R:R:Y36	14.516	3.75	No	Yes	0	6	5
11	R:R:V85	R:R:Y301	35.1632	5.05	Yes	Yes	2	7	8
12	R:R:V81	R:R:V85	50.1822	3.21	No	Yes	0	7	7
13	R:R:F115	R:R:V81	63.5179	7.87	Yes	No	0	7	7
14	R:R:F115	R:R:W157	71.5779	4.01	Yes	Yes	0	7	9
15	R:R:H122	R:R:W157	72.8771	4.23	Yes	Yes	0	8	9
16	R:R:H122	R:R:L74	100	6.43	Yes	No	0	8	9
17	R:R:L74	R:R:N307	99.7148	12.36	No	No	0	9	9
18	R:R:N307	R:R:P308	22.9761	4.89	No	No	0	9	9
19	R:R:N50	R:R:P308	20.3343	13.03	Yes	No	7	9	9
20	R:R:M86	R:R:W298	12.1079	9.31	Yes	Yes	0	7	5
21	R:R:N307	R:R:Y311	88.3199	6.98	No	Yes	0	9	9
22	R:R:I126	R:R:Y311	52.9903	2.42	No	Yes	0	9	9
23	R:R:I126	R:R:V71	49.7624	1.54	No	No	0	9	8
24	R:R:I57	R:R:V71	49.0692	1.54	Yes	No	0	7	8
25	R:R:F318	R:R:I57	40.225	5.02	Yes	Yes	4	9	7
26	R:R:F318	R:R:W317	39.8329	8.02	Yes	Yes	0	9	6
27	R:R:W317	R:R:Y315	34.7235	15.43	Yes	No	0	6	8
28	R:R:R130	R:R:Y315	31.5787	3.09	No	No	0	9	8
29	R:R:I220	R:R:R130	30.5173	2.51	No	No	0	9	9
30	R:R:I220	R:R:Y131	27.3091	3.63	No	Yes	0	9	8
31	R:R:I132	R:R:Y131	12.3772	2.42	No	Yes	0	5	8
32	R:R:I132	R:R:Y140	11.1732	2.42	No	Yes	0	5	7
33	R:R:G82	R:R:V81	13.6526	5.52	No	No	0	7	7
34	R:R:G82	R:R:M86	12.8683	5.24	No	Yes	0	7	7
35	R:R:F88	R:R:H108	11.8148	5.66	No	No	0	5	5
36	R:R:F115	R:R:S114	17.4152	2.64	Yes	No	0	7	5
37	R:R:S114	R:R:S164	15.7478	6.52	No	No	0	5	7
38	R:R:F206	R:R:W271	15.2329	9.02	Yes	Yes	0	8	8
39	R:R:F117	R:R:W271	12.702	4.01	No	Yes	0	5	8
40	R:R:F117	R:R:Y163	11.6801	3.09	No	Yes	0	5	5
41	R:R:F168	R:R:Y163	11.799	3.09	Yes	Yes	1	5	5
42	R:R:C116	R:R:Y301	13.0981	2.69	No	Yes	0	7	8
43	R:R:C116	R:R:W271	13.5694	2.61	No	Yes	0	7	8
44	R:R:L120	R:R:W271	14.9358	5.69	Yes	Yes	3	7	8
45	R:R:F121	R:R:L120	15.0388	4.87	Yes	Yes	3	5	7
46	R:R:F121	R:R:S156	29.2221	3.96	Yes	No	0	5	7
47	R:R:F121	R:R:L205	13.1654	3.65	Yes	No	0	5	4
48	R:R:L123	R:R:Y311	58.3848	4.69	No	Yes	0	8	9
49	R:R:L123	R:R:M213	57.557	4.24	No	No	0	8	8
50	R:R:M213	R:R:S127	28.3626	7.67	No	No	0	8	8
51	R:R:S127	R:R:Y217	27.4121	3.82	No	Yes	0	8	9
52	R:R:M213	R:R:M264	28.3626	2.89	No	No	0	8	8
53	R:R:M264	R:R:Y217	27.4121	4.79	No	Yes	0	8	9
54	R:R:L201	R:R:Y163	12.1515	3.52	No	Yes	0	5	5
55	R:R:F168	R:R:L194	11.9732	6.09	Yes	No	0	5	4
56	R:R:D277	R:R:Y293	16.6865	2.3	Yes	Yes	0	5	4
57	R:R:D277	R:R:D281	11.3712	3.99	Yes	No	10	5	3
58	R:R:D281	R:R:F286	10.0879	8.36	No	No	0	3	2
59	R:R:L260	R:R:Y217	50.7803	3.52	No	Yes	0	7	9
60	R:R:F221	R:R:L260	48.7326	3.65	Yes	No	0	5	7
61	R:R:F221	R:R:K225	42.5895	1.24	Yes	No	0	5	5
62	R:R:K225	R:R:R229	23.4474	4.95	No	Yes	6	5	4
63	R:R:E253	R:R:K225	17.0707	18.9	No	No	6	7	5
64	R:R:R229	R:R:V249	15.0388	6.54	Yes	No	6	4	4
65	R:R:E253	R:R:V249	15.0151	4.28	No	No	6	7	4
66	R:R:E232	R:R:V249	25.8318	2.85	No	No	0	4	4
67	R:R:E232	R:R:R252	12.9436	5.82	No	No	0	4	6
68	R:R:S89	R:R:W298	11.3474	3.71	Yes	Yes	2	6	5
69	R:R:S89	R:R:V85	11.2761	3.23	Yes	Yes	2	6	7
70	R:R:S164	R:R:T113	10.5355	6.4	No	No	0	7	4
71	R:R:L201	R:R:L205	12.1435	2.77	No	No	0	5	4
72	R:R:H122	R:R:S156	29.3924	8.37	Yes	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8IW9_nogp

PDB Summary
PDB	8IW9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.61
Number of Linked Nodes	276
Number of Links	297
Number of Hubs	34
Number of Links mediated by Hubs	134
Number of Communities	10
Number of Nodes involved in Communities	43
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	47333
Length Of Smallest Path	3
Average Path Length	15.1205
Length of Longest Path	35
Minimum Path Strength	1.225
Average Path Strength	5.25287
Maximum Path Strength	15.695
Minimum Path Correlation	0.7
Average Path Correlation	0.932153
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	49.6613
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9811
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD04
Sequence	>8IW9_nogp_Chain_R C I K S S Y A P W P R A I L Y G V L G L G A L L A V F G N L L V I I A I L H F K Q L H T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S C W Y F G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D P L T Y P T K F T V S V S G L C I A L S W F F S V T Y S F S I F Y T G A N E E G I E E L V V A L T C V G G C Q A P L N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E G T A S Y K E R V A K R E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M N F I T P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W F R K A I K L I V S G K V F R A D S S T T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ITF	A	Orphan	Orphan	TAA9	Mus musculus	DMCHA	-	chim(NtGi1-Gs)/β1/γ2	3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8ITF (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	DMCHA	-		3.46	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1	A	Orphan	Orphan	TAA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW1 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	-	-		3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4	A	Orphan	Orphan	TAA9	Mus musculus	Spermidine	-	chim(NtGi1-Gs)/β1/γ2	3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW4 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	Spermidine	-		3.49	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7	A	Orphan	Orphan	TAA9	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW7 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	2-Phenylethylamine	-		2.97	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9	A	Orphan	Orphan	TAA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IW9 (No Gprot)	A	Orphan	Orphan	TAA9	Mus musculus	-	-		3.08	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWE	A	Orphan	Orphan	TAA9	Mus musculus	Spermidine	-	-	3.4	2023-05-31	doi.org/10.1038/s41586-023-06106-4
	8IWM	A	Orphan	Orphan	TAA9	Mus musculus	2-Phenylethylamine	-	-	3.17	2023-05-31	doi.org/10.1038/s41586-023-06106-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IW9_nogp.zip

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