Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.8025402
2A:A:Y37 6.6925404
3A:A:H41 5.095406
4A:A:L45 4.522588
5A:A:S51 3.6925489
6A:A:K53 3.906589
7A:A:V214 3.834596
8A:A:F219 4.61333698
9A:A:F222 6.25333617
10A:A:Q227 3.81519
11A:A:K233 5.01143719
12A:A:W234 3.85167619
13A:A:C237 3.144518
14A:A:F238 5.02875819
15A:A:F246 2.49409
16A:A:V247 3.8825487
17A:A:F273 3.535639
18A:A:W277 7.185636
19A:A:W281 8.435615
20A:A:L289 4.18539
21A:A:F290 4.5575459
22A:A:L291 3.34638
23A:A:N292 3.9925489
24A:A:Q294 6.5425436
25A:A:E309 4.54754134
26A:A:F312 3.8056138
27A:A:E314 6.5254136
28A:A:F315 12.954136
29A:A:Y318 6.3175406
30A:A:P321 5.268535
31A:A:E330 9.498533
32A:A:V334 3.77404
33A:A:K338 6.57435
34A:A:Y339 6.788533
35A:A:F340 6.528336137
36A:A:R342 5.41833634
37A:A:E344 5.68754135
38A:A:F345 5.57143738
39A:A:L346 4.255434
40A:A:S349 3.178537
41A:A:Y358 5.1325454
42A:A:C359 2.915435
43A:A:Y360 4.95571758
44A:A:H362 6.1725459
45A:A:F363 6.402535
46A:A:T364 5.8625459
47A:A:D368 4.63559
48A:A:R373 5.3675495
49A:A:F376 4.02167698
50A:A:D381 6.1225458
51A:A:I383 2.87498
52A:A:R385 6.252555
53A:A:L388 4.205408
54B:B:E12 5.1485144
55B:B:L30 5.03405
56B:B:I37 3.533336122
57B:B:H54 8.8575429
58B:B:K57 8.626519
59B:B:I58 4.204529
60B:B:Y59 7.225418
61B:B:W63 6.24333627
62B:B:V71 5.5275478
63B:B:Q75 7.5175419
64B:B:I81 3.905477
65B:B:W82 10.198529
66B:B:D83 7.1554208
67B:B:S84 3.965425
68B:B:Y85 11.6675424
69B:B:N88 6.94254207
70B:B:K89 6.374529
71B:B:H91 4.3275475
72B:B:I93 5.1025477
73B:B:L95 4.6578
74B:B:W99 7.52857719
75B:B:M101 3.94409
76B:B:Y105 3.39143776
77B:B:N110 6.2154104
78B:B:Y111 6.12254104
79B:B:C114 3.0825478
80B:B:I123 3.5965106
81B:B:Y124 4.47571776
82B:B:E130 5.3075403
83B:B:V133 5.0225474
84B:B:L139 6.7125409
85B:B:H142 4.81429719
86B:B:Y145 4.69375818
87B:B:C149 2.778518
88B:B:F151 4.7325419
89B:B:L152 3.78254233
90B:B:T159 5.4425419
91B:B:S161 7.435419
92B:B:D163 4.82519
93B:B:T165 3.3075417
94B:B:W169 8.035618
95B:B:I171 3.91254106
96B:B:F180 7.976567
97B:B:H183 7.43833669
98B:B:D186 5.16519
99B:B:V187 5.5475469
100B:B:M188 5.3418
101B:B:L190 3.505465
102B:B:F199 6.358569
103B:B:S201 4.492569
104B:B:C204 6.222517
105B:B:D205 6.38469
106B:B:K209 9.9525466
107B:B:L210 3.808515
108B:B:W211 8.098568
109B:B:E215 10.175413
110B:B:R219 4.748515
111B:B:Q220 6.2125417
112B:B:F222 7.2075418
113B:B:H225 8.41857719
114B:B:D228 7.964519
115B:B:I232 6.4175418
116B:B:F235 6.416176
117B:B:P236 6.75254177
118B:B:N237 6.47405
119B:B:F241 6.3716
120B:B:T243 4.01833618
121B:B:G244 2.2875415
122B:B:D246 4.12419
123B:B:D247 7.9125419
124B:B:T249 4.81167616
125B:B:C250 2.7675418
126B:B:R251 10.33518
127B:B:F253 5.996516
128B:B:R256 8.4875409
129B:B:D258 6.458517
130B:B:Y264 4.952505
131B:B:I269 3.285414
132B:B:C271 4.22415
133B:B:T274 4.0325418
134B:B:F278 6.22754177
135B:B:R283 7.8654129
136B:B:Y289 6.36571717
137B:B:D290 6.8125416
138B:B:N295 7.03516
139B:B:V296 2.375405
140B:B:W297 5.716518
141B:B:K301 4.5825125
142B:B:R304 6.265415
143B:B:A305 1.9475404
144B:B:H311 6.984529
145B:B:R314 11.95518
146B:B:C317 3.3825427
147B:B:L318 2.94526
148B:B:T321 6.1925427
149B:B:V327 3.2775426
150B:B:T329 3.138528
151B:B:G330 2.2925425
152B:B:W332 9.08143719
153B:B:D333 6.925429
154B:B:F335 3.6475404
155B:B:K337 4.388526
156B:B:I338 3.37425
157B:B:W339 5.45333629
158G:G:Q18 3.1175409
159G:G:R27 4.878518
160G:G:D48 7.5025129
161G:G:L51 4.7256126
162G:G:F61 5.0075828
163R:R:Y36 4.4725405
164R:R:N50 7.3025259
165R:R:I57 3.331676187
166R:R:F60 4.865265
167R:R:N68 4.754189
168R:R:V85 4.045167
169R:R:M86 4.8625407
170R:R:S89 4.344166
171R:R:E95 9.27754155
172R:R:W98 4.665278
173R:R:C105 4.1954279
174R:R:F115 4.95507
175R:R:F117 2.92445
176R:R:L120 5.09447
177R:R:F121 3.275645
178R:R:H122 6.1525448
179R:R:Y131 8.312508
180R:R:P137 3.15833698
181R:R:L138 3.305496
182R:R:Y140 5.098336197
183R:R:F144 6.2054196
184R:R:W157 3.69649
185R:R:Y163 3.50286745
186R:R:F168 5.51143745
187R:R:Q191 4.3675401
188R:R:N195 6.7444
189R:R:W198 6.0175446
190R:R:L205 2.8444
191R:R:F206 6.536548
192R:R:P209 2.835449
193R:R:M213 4.3225408
194R:R:Y217 3.176509
195R:R:I220 2.9075409
196R:R:Q227 6.82556
197R:R:R229 5.0654114
198R:R:K230 9.8975453
199R:R:E232 7.674114
200R:R:Y245 2.615113
201R:R:V249 4.04754114
202R:R:R252 4.8845116
203R:R:F267 5.15649
204R:R:W271 5.28429748
205R:R:D277 4.73754285
206R:R:F286 6.0275402
207R:R:Y293 4.52404
208R:R:W298 7.636165
209R:R:Y301 7.458336168
210R:R:Y311 5.0325409
211R:R:W317 6.374506
212R:R:F318 5.8554189
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:S316 13.33683.44YesNo079
2B:B:S316 B:B:W332 13.48344.94NoYes099
3B:B:W332 B:B:Y59 38.48578.68YesYes198
4A:A:C237 B:B:Y59 38.5154.03YesYes188
5A:A:C237 A:A:F238 40.52572.79YesYes189
6A:A:F238 A:A:L44 98.27913.4YesNo099
7A:A:L44 A:A:L46 98.3448.3NoNo098
8A:A:G47 A:A:L46 98.69741.71NoNo098
9A:A:G47 A:A:K53 98.0043.49NoYes899
10A:A:K53 A:A:L45 98.92535.64YesYes898
11A:A:I245 A:A:L45 99.34082.85NoYes078
12A:A:I245 A:A:L43 99.46132.85NoNo077
13A:A:F219 A:A:L43 99.52152.44YesNo087
14A:A:F219 A:A:H41 66.89495.66YesYes086
15A:A:H41 A:A:I383 33.49582.65YesYes068
16A:A:H41 R:R:L138 33.44583.86YesYes066
17A:A:F219 A:A:F376 33.572.14YesYes988
18A:A:F376 R:R:L138 33.91682.44YesYes986
19A:A:I383 R:R:P137 33.41823.39YesYes988
20A:A:Q384 R:R:P137 1004.74NoYes068
21A:A:Q384 R:R:Q227 99.77096.4NoYes066
22R:R:L138 R:R:P137 67.19633.28YesYes968
23A:A:F238 A:A:W234 49.66652YesYes199
24A:A:W234 B:B:Y145 26.22.89YesYes198
25A:A:R231 A:A:W234 28.59014NoYes099
26A:A:D272 A:A:R231 28.44984.76NoNo089
27B:B:R314 B:B:W332 16.207323.99YesYes189
28A:A:D272 A:A:F246 28.30942.39NoYes089
29A:A:F246 A:A:V248 12.21032.62YesNo097
30A:A:F246 A:A:L289 15.67732.44YesYes099
31A:A:F345 A:A:L270 11.22229.74YesNo086
32A:A:L388 R:R:Q227 94.30872.66YesYes086
33A:A:L388 R:R:V134 91.23884.47YesNo088
34R:R:I220 R:R:V134 91.11633.07YesNo098
35B:B:G202 B:B:S201 12.43693.71NoYes069
36B:B:G202 B:B:I229 12.31531.76NoNo067
37B:B:I229 B:B:T243 10.57123.04NoYes178
38B:B:S201 B:B:V187 12.38066.46YesYes699
39B:B:S160 B:B:V187 16.34766.46NoYes069
40B:B:S147 B:B:S160 16.46983.26NoNo096
41B:B:C271 B:B:D290 17.45283.11YesYes156
42B:B:C271 B:B:Y289 16.03764.03YesYes157
43B:B:W297 B:B:Y289 12.01925.79YesYes187
44B:B:W297 B:B:Y264 11.49828.68YesYes085
45R:R:I220 R:R:Y217 81.19552.42YesYes099
46R:R:S127 R:R:Y217 40.21313.82NoYes089
47R:R:M213 R:R:S127 40.07177.67YesNo088
48R:R:F267 R:R:M213 70.8282.49YesYes098
49R:R:F206 R:R:F267 14.47952.14YesYes489
50R:R:F206 R:R:I275 10.429711.3YesNo087
51R:R:Y274 R:R:Y293 17.70563.97NoYes064
52R:R:Q191 R:R:Y293 11.49186.76YesYes014
53R:R:M264 R:R:Y217 40.21314.79NoYes089
54R:R:M213 R:R:M264 40.07172.89YesNo088
55R:R:F267 R:R:W271 47.02155.01YesYes498
56R:R:C116 R:R:W271 27.792.61NoYes078
57R:R:C116 R:R:Y301 27.47852.69NoYes078
58R:R:V85 R:R:Y301 10.25315.05YesYes1678
59R:R:F88 R:R:H108 17.32145.66NoNo055
60R:R:F100 R:R:F88 10.26669.65NoNo065
61B:B:S147 B:B:Y145 16.59873.82NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IW9
Class A
SubFamily Orphan
Type A orphans
SubType TAAR9
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.08
Date 2023-05-31
D.O.I. 10.1038/s41586-023-06106-4
Net Summary
Imin 1.75
Number of Linked Nodes 881
Number of Links 1150
Number of Hubs 212
Number of Links mediated by Hubs 767
Number of Communities 29
Number of Nodes involved in Communities 320
Number of Links involved in Communities 483
Path Summary
Number Of Nodes in MetaPath 62
Number Of Links MetaPath 61
Number of Shortest Paths 2388354
Length Of Smallest Path 3
Average Path Length 30.6833
Length of Longest Path 52
Minimum Path Strength 1.09
Average Path Strength 4.69096
Maximum Path Strength 18.97
Minimum Path Correlation 0.7
Average Path Correlation 0.984273
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 37.7664
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.4321
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8IW9_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GADNSGKST 
IVKQMRIYH VKTSGIFET KFQVDKVNF HMFDVGAQR DERRKWIQC 
FNDVTAIIF VVDSSRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IW9_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IW9_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5QD04
Sequence
>8IW9_Chain_R
CIKSSYAPW PRAILYGVL GLGALLAVF GNLLVIIAI LHFKQLHTP 
TNFLVASLA CADFLVGVT VMPFSTVRS VESCWYFGE SYCKFHTCF 
DTSFCFASL FHLCCISID RYIAVTDPL TYPTKFTVS VSGLCIALS 
WFFSVTYSF SIFYTGANE EGIEELVVA LTCVGGCQA PLNQNWVLL 
CFLLFFLPT VVMVFLYGR IFLVAKYQA RKIEGTASY KERVAKRER 
KAAKTLGIA MAAFLVSWL PYIIDAVID AYMNFITPA YVYEILVWC 
VYYNSAMNP LIYAFFYPW FRKAIKLIV SGKVFRADS STT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ITFAOrphanA orphansTAAR9Mus musculusDMCHA-chim(NtGi1-Gs)/&β;1/&γ;23.462023-05-3110.1038/s41586-023-06106-4
8IW1AOrphanA orphansTAAR9Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;23.42023-05-3110.1038/s41586-023-06106-4
8IW4AOrphanA orphansTAAR9Mus musculusSpermidine-chim(NtGi1-Gs)/&β;1/&γ;23.492023-05-3110.1038/s41586-023-06106-4
8IW7AOrphanA orphansTAAR9Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;22.972023-05-3110.1038/s41586-023-06106-4
8IW9AOrphanA orphansTAAR9Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;23.082023-05-3110.1038/s41586-023-06106-4
8IWEAOrphanA orphansTAAR9Mus musculusSpermidine--3.42023-05-3110.1038/s41586-023-06106-4
8IWMAOrphanA orphansTAAR9Mus musculus2-Phenylethylamine--3.172023-05-3110.1038/s41586-023-06106-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IW9.zip



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