Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 2.8025402
2A:A:Y37 6.6925404
3A:A:H41 5.095406
4A:A:L45 4.522588
5A:A:N50 4.84409
6A:A:S51 3.6925489
7A:A:K53 3.906589
8A:A:R61 7.7025408
9A:A:V214 3.834596
10A:A:F219 4.61333698
11A:A:F222 6.25333617
12A:A:D223 3.7975489
13A:A:Q227 3.81519
14A:A:K233 5.155619
15A:A:W234 3.85167619
16A:A:C237 3.144518
17A:A:F238 5.02875819
18A:A:F246 2.49409
19A:A:V247 3.8825487
20A:A:F273 3.535639
21A:A:W277 7.185636
22A:A:W281 8.435615
23A:A:L289 4.18539
24A:A:F290 4.5575459
25A:A:L291 3.34638
26A:A:N292 3.9925489
27A:A:Q294 6.5425436
28A:A:F312 2.522508
29A:A:Y318 6.3175406
30A:A:P321 5.268535
31A:A:V334 3.0175404
32A:A:Y339 6.788533
33A:A:F340 9.443336197
34A:A:R342 5.41833634
35A:A:F345 5.57143738
36A:A:L346 4.255434
37A:A:S349 3.178537
38A:A:Y358 5.1325454
39A:A:C359 2.915435
40A:A:Y360 4.95571758
41A:A:H362 6.1725459
42A:A:F363 6.402535
43A:A:T364 5.8625459
44A:A:D368 6.968559
45A:A:N371 5.3325459
46A:A:R373 5.3675495
47A:A:R374 9.145454
48A:A:F376 4.02167698
49A:A:D381 4.05458
50A:A:I383 2.87498
51A:A:R385 6.252555
52A:A:L388 4.205408
53B:B:L7 4.735408
54B:B:L30 5.03405
55B:B:I37 3.9485122
56B:B:H54 8.8575449
57B:B:K57 8.626519
58B:B:I58 4.204549
59B:B:Y59 7.225418
60B:B:W63 6.24333607
61B:B:V71 5.5275478
62B:B:Q75 7.5175419
63B:B:I81 3.905477
64B:B:W82 10.198549
65B:B:D83 7.1554188
66B:B:S84 3.9654115
67B:B:Y85 11.66754114
68B:B:N88 6.94254187
69B:B:K89 6.374549
70B:B:H91 4.3275475
71B:B:I93 5.1025477
72B:B:L95 4.6578
73B:B:W99 7.52857719
74B:B:M101 3.94409
75B:B:Y105 3.39143776
76B:B:N110 6.2154104
77B:B:Y111 6.12254104
78B:B:C114 3.0825478
79B:B:I123 3.5965106
80B:B:Y124 4.47571776
81B:B:E130 2.9825403
82B:B:V133 5.0225474
83B:B:L139 6.7125409
84B:B:H142 4.81429719
85B:B:Y145 6.13818
86B:B:C149 3.02408
87B:B:F151 4.73254229
88B:B:L152 3.78254233
89B:B:T159 5.4425419
90B:B:S161 7.435419
91B:B:G162 5.305419
92B:B:D163 4.82519
93B:B:W169 8.035618
94B:B:I171 3.91254106
95B:B:F180 7.976567
96B:B:H183 6.76714769
97B:B:V187 5.5475469
98B:B:M188 5.3418
99B:B:L190 3.505465
100B:B:F199 6.358569
101B:B:V200 4.3025416
102B:B:S201 4.492569
103B:B:C204 5.8325417
104B:B:D205 6.38469
105B:B:K209 9.9525466
106B:B:L210 3.808515
107B:B:W211 8.098568
108B:B:D212 4.312519
109B:B:R219 4.1225415
110B:B:Q220 6.2125417
111B:B:F222 7.2075418
112B:B:H225 8.41857719
113B:B:D228 7.964519
114B:B:I232 6.4175418
115B:B:F234 4.16571715
116B:B:F235 6.416156
117B:B:P236 6.75254157
118B:B:F241 6.58375816
119B:B:T243 4.01833618
120B:B:G244 2.2875415
121B:B:D246 4.12419
122B:B:D247 7.9125419
123B:B:T249 4.81167616
124B:B:R251 10.33518
125B:B:F253 5.996516
126B:B:D258 6.458517
127B:B:Y264 4.952505
128B:B:I269 3.285414
129B:B:C271 4.22415
130B:B:T274 4.0325418
131B:B:F278 6.22754157
132B:B:R283 7.8654129
133B:B:Y289 6.36571717
134B:B:D290 6.8125416
135B:B:N295 7.03516
136B:B:V296 2.375405
137B:B:W297 5.716518
138B:B:K301 4.694125
139B:B:R304 6.265415
140B:B:A305 1.64404
141B:B:H311 6.984549
142B:B:R314 11.95518
143B:B:C317 3.3825447
144B:B:L318 2.94546
145B:B:T321 6.19254217
146B:B:V327 3.2775446
147B:B:T329 3.138548
148B:B:G330 2.2925445
149B:B:W332 9.08143719
150B:B:D333 8.9225449
151B:B:F335 3.6475404
152B:B:K337 4.388546
153B:B:I338 3.374115
154B:B:W339 5.45333649
155G:G:R27 4.878518
156G:G:D48 7.5025129
157G:G:L51 4.7256126
158G:G:F61 5.00758118
159R:R:Y36 4.4725405
160R:R:N50 7.3025249
161R:R:I57 3.331676167
162R:R:F60 5.8165255
163R:R:N68 4.754169
164R:R:V85 4.045147
165R:R:M86 4.8625407
166R:R:S89 4.344146
167R:R:W98 4.665268
168R:R:F115 4.95507
169R:R:F117 2.92425
170R:R:L120 5.09427
171R:R:F121 3.275625
172R:R:H122 6.1525428
173R:R:Y131 8.312508
174R:R:P137 3.15833698
175R:R:L138 3.305496
176R:R:Y140 5.098336177
177R:R:F144 6.2054176
178R:R:W157 3.69629
179R:R:Y163 3.50286725
180R:R:F168 5.51143725
181R:R:V182 3.83754272
182R:R:Q191 4.9854271
183R:R:W198 6.0175426
184R:R:L205 2.8424
185R:R:F206 6.536528
186R:R:P209 2.835429
187R:R:M213 4.3225408
188R:R:Y217 3.176509
189R:R:I220 2.9075409
190R:R:Q227 6.49456
191R:R:R229 5.0654134
192R:R:E232 5.3454134
193R:R:Y245 2.615133
194R:R:V249 4.04754134
195R:R:R252 3.9725406
196R:R:F267 5.15629
197R:R:W271 5.28429728
198R:R:D277 4.73754285
199R:R:Y293 4.52404
200R:R:W298 7.636145
201R:R:Y301 7.458336148
202R:R:Y311 5.0325409
203R:R:W317 6.374506
204R:R:F318 5.8554169
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:S316 10.13283.44YesNo079
2B:B:S316 B:B:W332 10.2764.94NoYes099
3B:B:W332 B:B:Y59 59.99448.68YesYes198
4A:A:C237 B:B:Y59 59.54264.03YesYes188
5A:A:C237 A:A:F238 58.00852.79YesYes189
6A:A:F238 A:A:L44 97.637813.4YesNo099
7A:A:L44 A:A:L46 97.69668.3NoNo098
8A:A:G47 A:A:L46 98.03221.71NoNo098
9A:A:G47 A:A:K53 97.12483.49NoYes899
10A:A:K53 A:A:L45 97.72695.64YesYes898
11A:A:I245 A:A:L45 99.16232.85NoYes078
12A:A:I245 A:A:L43 99.26752.85NoNo077
13A:A:F219 A:A:L43 99.32012.44YesNo087
14A:A:F219 A:A:H41 66.93355.66YesYes086
15A:A:H41 A:A:I383 33.51072.65YesYes068
16A:A:H41 R:R:L138 33.45633.86YesYes066
17A:A:F219 A:A:F376 33.59832.14YesYes988
18A:A:F376 R:R:L138 34.01712.44YesYes986
19A:A:F238 A:A:W234 33.6752YesYes199
20A:A:W234 B:B:Y145 13.76492.89YesYes198
21A:A:R231 A:A:W234 22.2254NoYes099
22A:A:D272 A:A:R231 22.07874.76NoNo089
23A:A:W281 B:B:W332 21.65581.87YesYes159
24B:B:R314 B:B:W332 26.84623.99YesYes189
25A:A:Q384 R:R:Q227 99.74156.4NoYes066
26A:A:Q384 R:R:P137 1004.74NoYes068
27A:A:I383 R:R:P137 33.41743.39YesYes988
28R:R:L138 R:R:P137 67.28773.28YesYes968
29A:A:D272 A:A:F246 21.93252.39NoYes089
30A:A:F246 A:A:L289 12.52462.44YesYes099
31A:A:W281 B:B:D290 20.99456.7YesYes156
32B:B:D290 B:B:R314 20.950613.1YesYes168
33A:A:L388 R:R:Q227 94.68222.66YesYes086
34A:A:L388 R:R:V134 91.77684.47YesNo088
35R:R:I220 R:R:V134 91.64063.07YesNo098
36B:B:G244 B:B:T243 26.48341.82YesYes158
37B:B:F241 B:B:T243 13.11942.59YesYes168
38B:B:C271 B:B:D290 41.75973.11YesYes156
39B:B:C271 B:B:Y289 40.31624.03YesYes157
40B:B:W297 B:B:Y289 11.63775.79YesYes187
41B:B:W297 B:B:Y264 11.09768.68YesYes085
42B:B:I273 B:B:Y289 26.17378.46NoYes167
43B:B:G244 B:B:I273 25.63723.53YesNo156
44R:R:I220 R:R:Y217 80.62332.42YesYes099
45R:R:S127 R:R:Y217 39.88483.82NoYes089
46R:R:M213 R:R:S127 39.72987.67YesNo088
47R:R:F267 R:R:M213 69.34682.49YesYes098
48R:R:F206 R:R:F267 17.06252.14YesYes289
49R:R:F206 R:R:I275 11.300411.3YesNo087
50R:R:Y274 R:R:Y293 19.21183.97NoYes064
51R:R:M264 R:R:Y217 39.88484.79NoYes089
52R:R:M213 R:R:M264 39.72982.89YesNo088
53R:R:F267 R:R:W271 42.50165.01YesYes298
54R:R:V300 R:R:W271 10.32666.13NoYes078
55R:R:C116 R:R:W271 20.87122.61NoYes078
56R:R:C116 R:R:Y301 20.5322.69NoYes078
57R:R:L123 R:R:M213 10.46944.24NoYes088
58R:R:L123 R:R:Y311 10.12624.69NoYes089
59R:R:F117 R:R:W271 10.67954.01YesYes258
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IW9
Class A
SubFamily Orphan
Type Orphan
SubType TA9
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.08
Date 2023-05-31
D.O.I. 10.1038/s41586-023-06106-4
Net Summary
Imin 1.82
Number of Linked Nodes 877
Number of Links 1128
Number of Hubs 204
Number of Links mediated by Hubs 736
Number of Communities 28
Number of Nodes involved in Communities 295
Number of Links involved in Communities 448
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 2298411
Length Of Smallest Path 3
Average Path Length 30.6069
Length of Longest Path 51
Minimum Path Strength 1.225
Average Path Strength 4.82529
Maximum Path Strength 18.97
Minimum Path Correlation 0.7
Average Path Correlation 0.983409
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 36.9093
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.5538
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8IW9_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GADNSGKST 
IVKQMRIYH VKTSGIFET KFQVDKVNF HMFDVGAQR DERRKWIQC 
FNDVTAIIF VVDSSRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IW9_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IW9_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ5QD04
Sequence
>8IW9_Chain_R
CIKSSYAPW PRAILYGVL GLGALLAVF GNLLVIIAI LHFKQLHTP 
TNFLVASLA CADFLVGVT VMPFSTVRS VESCWYFGE SYCKFHTCF 
DTSFCFASL FHLCCISID RYIAVTDPL TYPTKFTVS VSGLCIALS 
WFFSVTYSF SIFYTGANE EGIEELVVA LTCVGGCQA PLNQNWVLL 
CFLLFFLPT VVMVFLYGR IFLVAKYQA RKIEGTASY KERVAKRER 
KAAKTLGIA MAAFLVSWL PYIIDAVID AYMNFITPA YVYEILVWC 
VYYNSAMNP LIYAFFYPW FRKAIKLIV SGKVFRADS STT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IWMAOrphanOrphanTA9Mus musculus2-Phenylethylamine--3.172023-05-3110.1038/s41586-023-06106-4
8IWEAOrphanOrphanTA9Mus musculusSpermidine--3.42023-05-3110.1038/s41586-023-06106-4
8IW9AOrphanOrphanTA9Mus musculus--chim(NtGi1-Gs)/β1/γ23.082023-05-3110.1038/s41586-023-06106-4
8IW9 (No Gprot) AOrphanOrphanTA9Mus musculus--3.082023-05-3110.1038/s41586-023-06106-4
8IW7AOrphanOrphanTA9Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ22.972023-05-3110.1038/s41586-023-06106-4
8IW7 (No Gprot) AOrphanOrphanTA9Mus musculus2-Phenylethylamine-2.972023-05-3110.1038/s41586-023-06106-4
8IW4AOrphanOrphanTA9Mus musculusSpermidine-chim(NtGi1-Gs)/β1/γ23.492023-05-3110.1038/s41586-023-06106-4
8IW4 (No Gprot) AOrphanOrphanTA9Mus musculusSpermidine-3.492023-05-3110.1038/s41586-023-06106-4
8IW1AOrphanOrphanTA9Mus musculus--chim(NtGi1-Gs)/β1/γ23.42023-05-3110.1038/s41586-023-06106-4
8IW1 (No Gprot) AOrphanOrphanTA9Mus musculus--3.42023-05-3110.1038/s41586-023-06106-4
8ITFAOrphanOrphanTA9Mus musculusDMCHA-chim(NtGi1-Gs)/β1/γ23.462023-05-3110.1038/s41586-023-06106-4
8ITF (No Gprot) AOrphanOrphanTA9Mus musculusDMCHA-3.462023-05-3110.1038/s41586-023-06106-4




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