psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	10.77	Yes	Yes	1	0	6
2	L:L:?1	R:R:T113	17.54	Yes	No	0	0	4
3	L:L:?1	R:R:C116	6.3	Yes	No	1	0	7
4	L:L:?1	R:R:C202	4.72	Yes	No	0	0	5
5	L:L:?1	R:R:Y274	12.79	Yes	Yes	0	0	6
6	L:L:?1	R:R:Y301	3.49	Yes	Yes	1	0	8
7	R:R:L39	R:R:W298	18.22	No	Yes	0	7	5
8	R:R:L41	R:R:L45	4.15	No	No	0	4	4
9	R:R:A46	R:R:D78	4.63	No	No	0	7	9
10	R:R:F79	R:R:V47	5.24	No	No	0	7	6
11	R:R:A75	R:R:N50	4.69	No	No	0	9	9
12	R:R:D78	R:R:N50	13.46	No	No	0	9	9
13	R:R:N50	R:R:P308	8.15	No	No	0	9	9
14	R:R:A75	R:R:V53	3.39	No	No	0	9	9
15	R:R:C76	R:R:I54	3.27	No	No	0	7	8
16	R:R:F60	R:R:H59	6.79	No	No	0	5	6
17	R:R:F60	R:R:Q62	11.71	No	No	0	5	6
18	R:R:H64	R:R:K61	18.34	No	No	0	7	6
19	R:R:L63	R:R:Q62	14.64	No	No	6	8	6
20	R:R:A321	R:R:Q62	4.55	No	No	6	7	6
21	R:R:A321	R:R:L63	4.73	No	No	6	7	8
22	R:R:F69	R:R:H64	3.39	No	No	0	5	7
23	R:R:P66	R:R:T65	3.5	No	No	0	6	8
24	R:R:T65	R:R:T67	4.71	No	Yes	3	8	8
25	R:R:N68	R:R:T65	8.77	Yes	No	3	9	8
26	R:R:P66	R:R:V146	3.53	No	No	0	6	3
27	R:R:N68	R:R:T67	4.39	Yes	Yes	3	9	8
28	R:R:D129	R:R:T67	7.23	No	Yes	3	9	8
29	R:R:T67	R:R:Y140	3.75	Yes	Yes	3	8	7
30	R:R:N68	R:R:W317	9.04	Yes	No	0	9	6
31	R:R:H122	R:R:S73	6.97	Yes	No	7	8	9
32	R:R:I153	R:R:S73	12.39	No	No	0	8	9
33	R:R:S73	R:R:W157	4.94	No	No	7	9	9
34	R:R:H122	R:R:L74	9	Yes	No	0	8	9
35	R:R:L74	R:R:N307	13.73	No	Yes	0	9	9
36	R:R:D78	R:R:S304	7.36	No	No	0	9	9
37	R:R:F79	R:R:V83	6.55	No	No	0	7	4
38	R:R:F115	R:R:L80	3.65	Yes	No	0	7	7
39	R:R:G82	R:R:V81	3.68	No	Yes	0	7	7
40	R:R:V81	R:R:V85	4.81	Yes	Yes	0	7	7
41	R:R:F115	R:R:V81	6.55	Yes	Yes	0	7	7
42	R:R:S304	R:R:V81	4.85	No	Yes	0	9	7
43	R:R:G82	R:R:M86	3.49	No	Yes	0	7	7
44	R:R:T84	R:R:V83	4.76	No	No	0	5	4
45	R:R:F111	R:R:T84	3.89	Yes	No	0	5	5
46	R:R:H108	R:R:V85	6.92	Yes	Yes	1	5	7
47	R:R:F111	R:R:V85	7.87	Yes	Yes	1	5	7
48	R:R:D112	R:R:V85	7.3	Yes	Yes	1	6	7
49	R:R:V85	R:R:Y301	5.05	Yes	Yes	1	7	8
50	R:R:M86	R:R:P87	3.35	Yes	No	0	7	8
51	R:R:M86	R:R:W298	4.65	Yes	Yes	0	7	5
52	R:R:F88	R:R:V91	6.55	Yes	No	0	5	4
53	R:R:F88	R:R:W98	22.05	Yes	Yes	1	5	8
54	R:R:F100	R:R:F88	26.79	No	Yes	0	6	5
55	R:R:F88	R:R:H108	7.92	Yes	Yes	1	5	5
56	R:R:R92	R:R:S89	6.59	No	No	0	5	6
57	R:R:H108	R:R:S89	6.97	Yes	No	0	5	6
58	R:R:S89	R:R:Y301	3.82	No	Yes	0	6	8
59	R:R:T90	R:R:W298	6.06	No	Yes	0	6	5
60	R:R:R92	R:R:W98	13.99	No	Yes	0	5	8
61	R:R:E294	R:R:S93	7.19	No	No	0	4	4
62	R:R:S93	R:R:W298	3.71	No	Yes	0	4	5
63	R:R:E95	R:R:Y99	19.08	No	No	0	5	2
64	R:R:C97	R:R:Y99	4.03	No	No	0	4	2
65	R:R:W98	R:R:Y104	4.82	Yes	No	0	8	6
66	R:R:C105	R:R:W98	20.89	No	Yes	1	9	8
67	R:R:H108	R:R:W98	13.75	Yes	Yes	1	5	8
68	R:R:C190	R:R:W98	3.92	No	Yes	1	9	8
69	R:R:F100	R:R:Y104	8.25	No	No	0	6	6
70	R:R:C105	R:R:C190	7.28	No	No	1	9	9
71	R:R:K106	R:R:Y169	14.33	No	No	0	6	5
72	R:R:F107	R:R:F111	13.93	No	Yes	0	5	5
73	R:R:F107	R:R:Y169	4.13	No	No	0	5	5
74	R:R:F111	R:R:H108	3.39	Yes	Yes	1	5	5
75	R:R:F168	R:R:T109	19.46	No	No	0	5	5
76	R:R:A192	R:R:T109	3.36	No	No	0	4	5
77	R:R:C110	R:R:F165	6.98	No	No	0	6	4
78	R:R:C110	R:R:F168	6.98	No	No	0	6	5
79	R:R:C110	R:R:Y169	6.72	No	No	0	6	5
80	R:R:F111	R:R:F115	7.5	Yes	Yes	0	5	7
81	R:R:C116	R:R:D112	4.67	No	Yes	1	7	6
82	R:R:D112	R:R:Y301	6.9	Yes	Yes	1	6	8
83	R:R:F115	R:R:S114	3.96	Yes	No	0	7	5
84	R:R:S114	R:R:V161	4.85	No	No	0	5	3
85	R:R:S114	R:R:S164	4.89	No	No	0	5	7
86	R:R:F117	R:R:F121	12.86	Yes	Yes	4	5	5
87	R:R:F117	R:R:S160	5.28	Yes	No	0	5	8
88	R:R:F117	R:R:Y163	8.25	Yes	No	4	5	5
89	R:R:F117	R:R:L205	8.53	Yes	No	4	5	4
90	R:R:A118	R:R:S160	3.42	No	No	0	7	8
91	R:R:L120	R:R:P209	4.93	No	No	0	7	9
92	R:R:L120	R:R:W271	27.33	No	Yes	0	7	8
93	R:R:F121	R:R:F159	4.29	Yes	No	4	5	4
94	R:R:F121	R:R:P209	7.22	Yes	No	0	5	9
95	R:R:H122	R:R:S156	12.55	Yes	No	0	8	7
96	R:R:H122	R:R:W157	4.23	Yes	No	7	8	9
97	R:R:L123	R:R:N307	6.87	No	Yes	8	8	9
98	R:R:L123	R:R:Y311	5.86	No	Yes	8	8	9
99	R:R:C124	R:R:V212	5.12	No	No	0	7	6
100	R:R:C125	R:R:C152	5.46	No	No	9	6	6
101	R:R:I126	R:R:R130	3.76	No	No	0	9	9
102	R:R:I126	R:R:Y311	6.04	No	Yes	0	9	9
103	R:R:M213	R:R:S127	7.67	No	No	0	8	8
104	R:R:S127	R:R:Y217	11.45	No	No	0	8	9
105	R:R:D129	R:R:Y140	9.2	No	Yes	3	9	7
106	R:R:D129	R:R:F144	10.75	No	No	3	9	6
107	R:R:R130	R:R:Y315	11.32	No	Yes	0	9	8
108	R:R:T135	R:R:Y131	21.22	No	No	0	6	8
109	R:R:L216	R:R:Y131	19.93	Yes	No	0	6	8
110	R:R:R219	R:R:Y131	4.12	No	No	0	4	8
111	R:R:F144	R:R:I132	7.54	No	No	0	6	5
112	R:R:A133	R:R:Y140	9.34	No	Yes	0	8	7
113	R:R:I220	R:R:V134	4.61	No	No	0	9	8
114	R:R:D136	R:R:T139	10.12	Yes	No	0	6	5
115	R:R:T139	R:R:T142	6.28	No	No	0	5	4
116	R:R:P141	R:R:Y140	5.56	No	Yes	0	4	7
117	R:R:F144	R:R:Y140	6.19	No	Yes	3	6	7
118	R:R:S147	R:R:T145	4.8	No	No	0	4	7
119	R:R:L205	R:R:Y163	3.52	No	No	4	4	5
120	R:R:F165	R:R:S164	3.96	No	No	0	4	7
121	R:R:A172	R:R:W198	5.19	No	No	0	6	6
122	R:R:E174	R:R:N173	10.52	No	No	0	4	4
123	R:R:L194	R:R:N173	4.12	No	No	0	4	4
124	R:R:E174	R:R:I177	4.1	No	No	0	4	1
125	R:R:E174	R:R:L180	14.58	No	No	0	4	2
126	R:R:E175	R:R:N195	3.94	No	No	0	2	4
127	R:R:L180	R:R:L184	8.3	No	Yes	5	2	4
128	R:R:L180	R:R:P193	6.57	No	No	5	2	3
129	R:R:T185	R:R:V181	4.76	No	No	0	2	1
130	R:R:L184	R:R:Q191	5.32	Yes	No	5	4	1
131	R:R:L184	R:R:P193	6.57	Yes	No	5	4	3
132	R:R:P193	R:R:Q191	4.74	No	No	5	3	1
133	R:R:N195	R:R:Q196	3.96	No	No	0	4	2
134	R:R:N195	R:R:W198	13.56	No	No	0	4	6
135	R:R:N197	R:R:W198	19.21	No	No	0	4	6
136	R:R:A282	R:R:V199	3.39	No	No	0	4	5
137	R:R:F203	R:R:F207	5.36	Yes	No	2	6	4
138	R:R:F203	R:R:I275	3.77	Yes	Yes	2	6	7
139	R:R:F203	R:R:V279	13.11	Yes	No	0	6	6
140	R:R:F206	R:R:T210	5.19	Yes	No	2	8	6
141	R:R:F206	R:R:F267	6.43	Yes	Yes	2	8	9
142	R:R:F206	R:R:W271	10.02	Yes	Yes	2	8	8
143	R:R:F206	R:R:L272	4.87	Yes	No	0	8	6
144	R:R:F206	R:R:I275	15.07	Yes	Yes	2	8	7
145	R:R:L208	R:R:P209	3.28	No	No	0	5	9
146	R:R:F267	R:R:T210	6.49	Yes	No	2	9	6
147	R:R:F267	R:R:M213	6.22	Yes	No	0	9	8
148	R:R:F215	R:R:L216	4.87	No	Yes	0	5	6
149	R:R:F215	R:R:R219	9.62	No	No	0	5	4
150	R:R:L260	R:R:Y217	9.38	No	No	0	7	9
151	R:R:I220	R:R:L260	4.28	No	No	0	9	7
152	R:R:F221	R:R:K225	3.72	Yes	No	0	5	5
153	R:R:A257	R:R:F221	4.16	No	Yes	0	7	5
154	R:R:E253	R:R:K225	17.55	No	No	0	7	5
155	R:R:K230	R:R:Y226	11.94	No	No	0	3	5
156	R:R:K230	R:R:Q227	4.07	No	No	0	3	6
157	R:R:A228	R:R:E253	6.03	No	No	0	4	7
158	R:R:E232	R:R:I231	6.83	No	No	0	4	7
159	R:R:F314	R:R:T259	9.08	No	No	0	7	8
160	R:R:F267	R:R:L268	3.65	Yes	No	0	9	6
161	R:R:F267	R:R:W271	4.01	Yes	Yes	2	9	8
162	R:R:N303	R:R:S270	4.47	No	No	0	9	8
163	R:R:I275	R:R:W271	5.87	Yes	Yes	2	7	8
164	R:R:V300	R:R:W271	22.07	No	Yes	0	7	8
165	R:R:N303	R:R:W271	6.78	No	Yes	0	9	8
166	R:R:L272	R:R:P273	4.93	No	No	0	6	9
167	R:R:I275	R:R:Y274	6.04	Yes	Yes	0	7	6
168	R:R:L296	R:R:Y274	8.21	No	Yes	0	5	6
169	R:R:V297	R:R:Y274	5.05	No	Yes	0	6	6
170	R:R:D277	R:R:I276	5.6	No	No	0	5	6
171	R:R:D281	R:R:T288	13.01	No	Yes	0	3	6
172	R:R:P289	R:R:V292	8.84	No	No	0	4	5
173	R:R:E294	R:R:Y291	3.37	No	No	0	4	2
174	R:R:W298	R:R:Y301	7.72	Yes	Yes	0	5	8
175	R:R:M306	R:R:Y302	9.58	No	No	0	5	6
176	R:R:N307	R:R:P308	3.26	Yes	No	0	9	9
177	R:R:N307	R:R:Y311	6.98	Yes	Yes	8	9	9
178	R:R:F313	R:R:L309	8.53	No	No	0	5	6
179	R:R:I310	R:R:Y311	7.25	No	Yes	0	8	9
180	R:R:A312	R:R:F318	4.16	No	No	0	7	9
181	R:R:F314	R:R:Y315	5.16	No	Yes	0	7	8
182	R:R:W317	R:R:Y315	12.54	No	Yes	0	6	8
183	R:R:F318	R:R:W317	8.02	No	No	0	9	6
184	R:R:F318	R:R:I322	5.02	No	No	0	9	7
185	R:R:A56	R:R:I322	3.25	No	No	0	7	7
186	R:R:A72	R:R:I57	3.25	No	No	0	6	7
187	R:R:S147	R:R:V148	3.23	No	No	0	4	6
188	R:R:A43	R:R:M86	3.22	No	Yes	0	6	7
189	R:R:D136	R:R:P137	3.22	Yes	No	0	6	8
190	R:R:V199	R:R:V279	3.21	No	No	0	5	6
191	R:R:C202	R:R:L194	3.17	No	No	0	5	4
192	R:R:M264	R:R:V214	3.04	No	No	0	8	5
193	R:R:L216	R:R:V212	2.98	Yes	No	0	6	6
194	R:R:Y274	R:R:Y293	2.98	Yes	No	0	6	4
195	R:R:L184	R:R:T185	2.95	Yes	No	0	4	2
196	R:R:I262	R:R:I310	2.94	No	No	0	6	8
197	R:R:A77	R:R:H122	2.93	No	Yes	0	8	8
198	R:R:I262	R:R:K258	2.91	No	No	0	6	7
199	R:R:I153	R:R:L70	2.85	No	No	0	8	8
200	R:R:I128	R:R:L216	2.85	No	Yes	0	7	6
201	R:R:I295	R:R:L296	2.85	No	No	0	5	5
202	R:R:I57	R:R:N68	2.83	No	Yes	0	7	9
203	R:R:I167	R:R:N173	2.83	No	No	0	5	4
204	R:R:A56	R:R:F60	2.77	No	No	0	7	5
205	R:R:D277	R:R:L296	2.71	No	No	0	5	5
206	R:R:A278	R:R:Y293	2.67	No	No	0	5	4
207	R:R:F69	R:R:I57	2.51	No	No	0	5	7
208	R:R:T288	R:R:Y293	2.5	Yes	No	0	6	4
209	R:R:F48	R:R:L44	2.44	No	No	0	4	5
210	R:R:F79	R:R:L51	2.44	No	No	0	7	4
211	R:R:F221	R:R:L222	2.44	Yes	No	0	5	3
212	R:R:Q196	R:R:Y283	2.25	No	No	0	2	4
213	R:R:G188	R:R:G189	2.11	No	No	0	4	3
214	R:R:F100	R:R:Y99	2.06	No	No	0	6	2
215	R:R:R229	R:R:Y226	2.06	No	No	0	4	5
216	R:R:G188	R:R:V187	1.84	No	No	0	4	3
217	R:R:A305	R:R:A46	1.79	No	No	0	7	7
218	R:R:A224	R:R:A256	1.79	No	No	0	8	8
219	R:R:G261	R:R:M264	1.75	No	No	0	5	8
220	R:R:P289	R:R:T288	1.75	No	Yes	0	4	6
221	R:R:G40	R:R:L39	1.71	No	No	0	4	7
222	R:R:G42	R:R:L41	1.71	No	No	0	6	4
223	R:R:C152	R:R:V148	1.71	No	No	0	6	6
224	R:R:C186	R:R:V181	1.71	No	No	0	3	1
225	R:R:A312	R:R:V71	1.7	No	No	0	7	8
226	R:R:A265	R:R:V269	1.7	No	No	0	5	5
227	R:R:E102	R:R:G101	1.64	No	No	0	3	8
228	R:R:E175	R:R:G176	1.64	No	No	0	2	3
229	R:R:S119	R:R:S304	1.63	No	No	0	9	9
230	R:R:A72	R:R:I54	1.62	No	No	0	6	8
231	R:R:A75	R:R:I54	1.62	No	No	0	9	8
232	R:R:A172	R:R:I167	1.62	No	No	0	6	5
233	R:R:A266	R:R:I310	1.62	No	No	0	7	8
234	R:R:A305	R:R:M306	1.61	No	No	0	7	5
235	R:R:V134	R:R:V223	1.6	No	No	0	8	5
236	R:R:S166	R:R:T170	1.6	No	No	0	6	5
237	R:R:V211	R:R:V212	1.6	No	No	0	3	6
238	R:R:C125	R:R:L70	1.59	No	No	9	6	8
239	R:R:C152	R:R:L70	1.59	No	No	9	6	8
240	R:R:T210	R:R:V211	1.59	No	No	0	6	3
241	R:R:A305	R:R:L45	1.58	No	No	0	7	4
242	R:R:I153	R:R:S149	1.55	No	No	0	8	7
243	R:R:I167	R:R:S166	1.55	No	No	0	5	6
244	R:R:I280	R:R:V279	1.54	No	No	0	4	6
245	R:R:I287	R:R:T288	1.52	No	Yes	0	3	6
246	R:R:F48	R:R:G49	1.51	No	No	0	4	8
247	R:R:K143	R:R:T139	1.5	No	No	0	4	5
248	R:R:G37	R:R:Y36	1.45	No	No	0	4	5
249	R:R:D136	R:R:T135	1.45	Yes	No	0	6	6
250	R:R:I55	R:R:L51	1.43	No	No	0	4	4
251	R:R:E95	R:R:V94	1.43	No	No	0	5	6
252	R:R:G101	R:R:W98	1.41	No	Yes	0	8	8
253	R:R:G189	R:R:W98	1.41	No	Yes	0	3	8
254	R:R:L309	R:R:M306	1.41	No	No	0	6	5
255	R:R:A154	R:R:F158	1.39	No	No	0	3	4
256	R:R:P316	R:R:Y315	1.39	No	Yes	0	4	8
257	R:R:L200	R:R:L201	1.38	No	No	0	5	5
258	R:R:D136	R:R:L138	1.36	Yes	No	0	6	6
259	R:R:A263	R:R:Y217	1.33	No	No	0	8	9
260	R:R:A290	R:R:Y291	1.33	No	No	0	3	2
261	R:R:F121	R:R:L155	1.22	Yes	No	4	5	2
262	R:R:F159	R:R:L155	1.22	No	No	4	4	2
263	R:R:F203	R:R:L204	1.22	Yes	No	2	6	4
264	R:R:F207	R:R:L204	1.22	No	No	2	4	4
265	R:R:F221	R:R:L260	1.22	Yes	No	0	5	7
266	R:R:E253	R:R:R229	1.16	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.26833	6	1	0
2	R:R:T67	5.02	4	3	8
3	R:R:N68	6.2575	4	3	9
4	R:R:V81	4.9725	4	0	7
5	R:R:V85	6.39	5	1	7
6	R:R:M86	3.6775	4	0	7
7	R:R:F88	15.8275	4	1	5
8	R:R:W98	10.28	8	1	8
9	R:R:H108	7.79	5	1	5
10	R:R:F111	7.316	5	1	5
11	R:R:D112	7.41	4	1	6
12	R:R:F115	5.415	4	0	7
13	R:R:F117	8.73	4	4	5
14	R:R:F121	6.3975	4	4	5
15	R:R:H122	7.136	5	7	8
16	R:R:D136	4.0375	4	0	6
17	R:R:Y140	6.808	5	3	7
18	R:R:L184	5.785	4	5	4
19	R:R:F203	5.865	4	2	6
20	R:R:F206	8.316	5	2	8
21	R:R:L216	7.6575	4	0	6
22	R:R:F221	2.885	4	0	5
23	R:R:F267	5.36	5	2	9
24	R:R:W271	12.68	6	2	8
25	R:R:Y274	7.014	5	0	6
26	R:R:I275	7.6875	4	2	7
27	R:R:T288	4.695	4	0	6
28	R:R:W298	8.072	5	0	5
29	R:R:Y301	5.396	5	1	8
30	R:R:N307	7.71	4	8	9
31	R:R:Y311	6.5325	4	8	9
32	R:R:Y315	7.6025	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y301	66.1216	3.49	Yes	Yes	1	0	8
2	L:L:?1	R:R:D112	49.8753	10.77	Yes	Yes	1	0	6
3	R:R:D112	R:R:V85	50.2798	7.3	Yes	Yes	1	6	7
4	R:R:V81	R:R:V85	79.8092	4.81	Yes	Yes	0	7	7
5	R:R:S304	R:R:V81	81.5016	4.85	No	Yes	0	9	7
6	R:R:D78	R:R:S304	79.7687	7.36	No	No	0	9	9
7	R:R:A46	R:R:D78	11.9513	4.63	No	No	0	7	9
8	R:R:A305	R:R:A46	10.65	1.79	No	No	0	7	7
9	R:R:V85	R:R:Y301	53.8096	5.05	Yes	Yes	1	7	8
10	R:R:F111	R:R:V85	21.7248	7.87	Yes	Yes	1	5	7
11	R:R:D78	R:R:N50	70.6999	13.46	No	No	0	9	9
12	R:R:A75	R:R:N50	38.4263	4.69	No	No	0	9	9
13	R:R:N50	R:R:P308	32.6546	8.15	No	No	0	9	9
14	R:R:A75	R:R:I54	36.1945	1.62	No	No	0	9	8
15	R:R:A72	R:R:I54	33.9492	1.62	No	No	0	6	8
16	R:R:A72	R:R:I57	32.8164	3.25	No	No	0	6	7
17	R:R:I57	R:R:N68	28.3629	2.83	No	Yes	0	7	9
18	R:R:N68	R:R:W317	14.7327	9.04	Yes	No	0	9	6
19	R:R:F318	R:R:W317	13.2156	8.02	No	No	0	9	6
20	R:R:N68	R:R:T67	11.6412	4.39	Yes	Yes	3	9	8
21	R:R:N307	R:R:P308	31.5555	3.26	Yes	No	0	9	9
22	R:R:L74	R:R:N307	18.3568	13.73	No	Yes	0	9	9
23	R:R:H122	R:R:L74	17.0892	9	Yes	No	0	8	9
24	R:R:H122	R:R:S73	11.921	6.97	Yes	No	7	8	9
25	R:R:I153	R:R:S73	10.65	12.39	No	No	0	8	9
26	R:R:F115	R:R:V81	11.658	6.55	Yes	Yes	0	7	7
27	R:R:H108	R:R:V85	19.9447	6.92	Yes	Yes	1	5	7
28	R:R:S89	R:R:Y301	13.0706	3.82	No	Yes	0	6	8
29	R:R:F88	R:R:H108	11.6782	7.92	Yes	Yes	1	5	5
30	R:R:H108	R:R:W98	15.208	13.75	Yes	Yes	1	5	8
31	R:R:F107	R:R:F111	11.2366	13.93	No	Yes	0	5	5
32	L:L:?1	R:R:Y274	100	12.79	Yes	Yes	0	0	6
33	R:R:I275	R:R:Y274	90.0917	6.04	Yes	Yes	0	7	6
34	R:R:I275	R:R:W271	38.8409	5.87	Yes	Yes	2	7	8
35	R:R:L120	R:R:W271	14.4663	27.33	No	Yes	0	7	8
36	R:R:L120	R:R:P209	13.1751	4.93	No	No	0	7	9
37	R:R:F121	R:R:P209	10.5724	7.22	Yes	No	0	5	9
38	R:R:N307	R:R:Y311	14.3382	6.98	Yes	Yes	8	9	9
39	R:R:F206	R:R:I275	44.5317	15.07	Yes	Yes	2	8	7
40	R:R:F206	R:R:T210	20.056	5.19	Yes	No	2	8	6
41	R:R:T210	R:R:V211	20.8179	1.59	No	No	0	6	3
42	R:R:V211	R:R:V212	19.5671	1.6	No	No	0	3	6
43	R:R:F206	R:R:F267	22.3485	6.43	Yes	Yes	2	8	9
44	R:R:F267	R:R:M213	42.0538	6.22	Yes	No	0	9	8
45	R:R:F267	R:R:W271	24.0071	4.01	Yes	Yes	2	9	8
46	R:R:M213	R:R:S127	39.7478	7.67	No	No	0	8	8
47	R:R:S127	R:R:Y217	37.4351	11.45	No	No	0	8	9
48	R:R:L216	R:R:V212	17.0454	2.98	Yes	No	0	6	6
49	R:R:L216	R:R:Y131	11.8873	19.93	Yes	No	0	6	8
50	R:R:L260	R:R:Y217	32.7793	9.38	No	No	0	7	9
51	L:L:?1	R:R:C202	30.6655	4.72	Yes	No	0	0	5
52	R:R:C202	R:R:L194	29.5496	3.17	No	No	0	5	4
53	R:R:L194	R:R:N173	28.4472	4.12	No	No	0	4	4
54	R:R:I167	R:R:N173	14.6821	2.83	No	No	0	5	4
55	R:R:A172	R:R:I167	10.7579	1.62	No	No	0	6	5
56	R:R:E174	R:R:N173	13.2762	10.52	No	No	0	4	4
57	R:R:E174	R:R:L180	10.6534	14.58	No	No	0	4	2
58	R:R:F221	R:R:L260	23.7307	1.22	Yes	No	0	5	7
59	R:R:F221	R:R:K225	16.6374	3.72	Yes	No	0	5	5
60	R:R:E253	R:R:K225	14.2506	17.55	No	No	0	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D112	10.77	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:T113	17.54	1	Yes	No	0	4	0	1
L:L:?1	R:R:C116	6.3	1	Yes	No	0	7	0	1
L:L:?1	R:R:C202	4.72	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y274	12.79	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y301	3.49	1	Yes	Yes	0	8	0	1
R:R:D112	R:R:V85	7.3	1	Yes	Yes	6	7	1	2
R:R:V85	R:R:Y301	5.05	1	Yes	Yes	7	8	2	1
R:R:S89	R:R:Y301	3.82	0	No	Yes	6	8	2	1
R:R:C116	R:R:D112	4.67	1	No	Yes	7	6	1	1
R:R:D112	R:R:Y301	6.9	1	Yes	Yes	6	8	1	1
R:R:I275	R:R:Y274	6.04	2	Yes	Yes	7	6	2	1
R:R:L296	R:R:Y274	8.21	0	No	Yes	5	6	2	1
R:R:V297	R:R:Y274	5.05	0	No	Yes	6	6	2	1
R:R:W298	R:R:Y301	7.72	0	Yes	Yes	5	8	2	1
R:R:C202	R:R:L194	3.17	0	No	No	5	4	1	2
R:R:Y274	R:R:Y293	2.98	0	Yes	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IW7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	246
Number of Links	266
Number of Hubs	32
Number of Links mediated by Hubs	118
Number of Communities	9
Number of Nodes involved in Communities	47
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	51707
Length Of Smallest Path	3
Average Path Length	14.7492
Length of Longest Path	34
Minimum Path Strength	1.405
Average Path Strength	6.88282
Maximum Path Strength	24.7
Minimum Path Correlation	0.7
Average Path Correlation	0.92481
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.2549
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5915
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PEA
Name	Phenethylamine
Synonyms	β-phenethylamine
Identifier
Formula	C8 H12 N
Molecular Weight	122.188
SMILES
PubChem	448751
Formal Charge	1
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q5QD04
Sequence	>8IW7_nogp_Chain_R Y G V L G L G A L L A V F G N L L V I I A I L H F K Q L H T P T N F L V A S L A C A D F L V G V T V M P F S T V R S V E S C W Y F G E S Y C K F H T C F D T S F C F A S L F H L C C I S I D R Y I A V T D P L T Y P T K F T V S V S G L C I A L S W F F S V T Y S F S I F Y T G A N E E G I E E L V V A L T C V G G C Q A P L N Q N W V L L C F L L F F L P T V V M V F L Y G R I F L V A K Y Q A R K I E E R K A A K T L G I A M A A F L V S W L P Y I I D A V I D A Y M N F I T P A Y V Y E I L V W C V Y Y N S A M N P L I Y A F F Y P W F R K A I K L I V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IWM	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	-	3.17	2023-05-31	10.1038/s41586-023-06106-4
	8IWE	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	-	3.4	2023-05-31	10.1038/s41586-023-06106-4
	8IW9	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.08	2023-05-31	10.1038/s41586-023-06106-4
	8IW9 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.08	2023-05-31	10.1038/s41586-023-06106-4
	8IW7	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	2.97	2023-05-31	10.1038/s41586-023-06106-4
	8IW7 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	2-Phenylethylamine	-		2.97	2023-05-31	10.1038/s41586-023-06106-4
	8IW4	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-	chim(NtGi1-Gs)/β1/γ2	3.49	2023-05-31	10.1038/s41586-023-06106-4
	8IW4 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	Spermidine	-		3.49	2023-05-31	10.1038/s41586-023-06106-4
	8IW1	A	Orphan	Orphan	TA9	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-05-31	10.1038/s41586-023-06106-4
	8IW1 (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	-	-		3.4	2023-05-31	10.1038/s41586-023-06106-4
	8ITF	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-	chim(NtGi1-Gs)/β1/γ2	3.46	2023-05-31	10.1038/s41586-023-06106-4
	8ITF (No Gprot)	A	Orphan	Orphan	TA9	Mus musculus	DMCHA	-		3.46	2023-05-31	10.1038/s41586-023-06106-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IW7_nogp.zip

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