Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F284 R:R:Q43 3.51 0 Yes No 3 3 1 1
L:L:K11 R:R:Q43 6.78 0 No No 0 3 0 1
R:R:N285 R:R:V46 4.43 0 No No 4 5 1 2
R:R:I289 R:R:V46 4.61 0 Yes No 5 5 2 2
R:R:F51 R:R:T101 7.78 30 Yes Yes 6 6 1 1
R:R:F51 R:R:I289 7.54 30 Yes Yes 6 5 1 2
R:R:F51 R:R:M292 7.46 30 Yes No 6 5 1 2
L:L:H6 R:R:F51 12.44 30 Yes Yes 0 6 0 1
R:R:I129 R:R:S96 7.74 0 Yes No 5 6 1 2
R:R:I129 R:R:N97 8.5 0 Yes No 5 6 1 2
R:R:M292 R:R:N97 7.01 0 No No 5 6 2 2
R:R:G98 R:R:T101 3.64 0 No Yes 6 6 2 1
R:R:E100 R:R:I125 9.56 0 Yes No 5 5 1 2
R:R:D126 R:R:E100 7.8 6 Yes Yes 4 5 1 1
R:R:E100 R:R:I129 4.1 0 Yes Yes 5 5 1 1
L:L:M4 R:R:E100 4.06 0 No Yes 0 5 0 1
L:L:H6 R:R:T101 6.85 30 Yes Yes 0 6 0 1
L:L:M4 R:R:I104 7.29 0 No No 0 4 0 1
L:L:Y2 R:R:V119 6.31 0 Yes No 0 3 0 1
R:R:D122 R:R:D126 7.98 6 Yes Yes 8 4 1 1
L:L:Y2 R:R:D122 11.49 0 Yes Yes 0 8 0 1
L:L:M4 R:R:D122 12.48 0 No Yes 0 8 0 1
L:L:R8 R:R:D122 3.57 6 Yes Yes 0 8 0 1
R:R:I185 R:R:N123 4.25 6 Yes No 5 5 1 1
L:L:R8 R:R:N123 3.62 6 Yes No 0 5 0 1
R:R:D126 R:R:I185 4.2 6 Yes Yes 4 5 1 1
L:L:F7 R:R:D126 4.78 6 Yes Yes 0 4 0 1
L:L:R8 R:R:D126 15.48 6 Yes Yes 0 4 0 1
R:R:I185 R:R:S127 9.29 6 Yes No 5 5 1 2
L:L:F7 R:R:I129 12.56 6 Yes Yes 0 5 0 1
R:R:C130 R:R:G181 3.92 0 Yes No 4 6 1 2
R:R:C130 R:R:F184 4.19 0 Yes Yes 4 4 1 2
R:R:C130 R:R:I185 3.27 0 Yes Yes 4 5 1 1
L:L:F7 R:R:C130 4.19 6 Yes Yes 0 4 0 1
R:R:L133 R:R:W258 4.56 0 No Yes 5 7 1 2
L:L:F7 R:R:L133 3.65 6 Yes No 0 5 0 1
R:R:F184 R:R:L197 4.87 0 Yes No 4 5 2 1
L:L:R8 R:R:I185 7.52 6 Yes Yes 0 5 0 1
R:R:D189 R:R:S188 4.42 0 No No 5 4 2 1
L:L:R8 R:R:S188 10.54 6 Yes No 0 4 0 1
L:L:W9 R:R:S188 3.71 6 Yes No 0 4 0 1
R:R:I194 R:R:L265 7.14 6 Yes No 4 5 1 1
R:R:I194 R:R:Y268 3.63 6 Yes No 4 5 1 1
R:R:I194 R:R:I269 5.89 6 Yes No 4 4 1 2
L:L:W9 R:R:I194 5.87 6 Yes Yes 0 4 0 1
L:L:W9 R:R:L197 3.42 6 Yes No 0 5 0 1
R:R:F261 R:R:L265 3.65 0 Yes No 5 5 2 1
R:R:F261 R:R:F284 6.43 0 Yes Yes 5 3 2 1
R:R:H264 R:R:M281 6.57 0 No No 4 3 2 1
R:R:F284 R:R:H264 10.18 0 Yes No 3 4 1 2
L:L:W9 R:R:L265 4.56 6 Yes No 0 5 0 1
L:L:W9 R:R:Y268 11.58 6 Yes No 0 5 0 1
R:R:P272 R:R:Q273 6.32 0 No No 3 1 1 2
L:L:P12 R:R:M281 5.03 0 No No 0 3 0 1
R:R:F284 R:R:L288 13.4 0 Yes No 3 4 1 1
L:L:G10 R:R:F284 10.54 0 No Yes 0 3 0 1
L:L:H6 R:R:N285 7.65 30 Yes No 0 4 0 1
L:L:H6 R:R:L288 3.86 30 Yes No 0 4 0 1
R:R:T101 R:R:V52 3.17 30 Yes No 6 4 1 2
R:R:N120 R:R:V119 2.96 0 No No 1 3 2 1
L:L:Y2 R:R:T118 2.5 0 Yes No 0 6 0 1
L:L:P12 R:R:P272 1.95 0 No No 0 3 0 1
R:R:P48 R:R:T101 1.75 0 Yes Yes 5 6 2 1
R:R:L107 R:R:T118 1.47 0 No No 4 6 2 1
L:L:V13 R:R:Y268 1.26 0 No No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7F53
Class A
SubFamily Peptide
Type Melanocortin
SubType MC4
Species Homo sapiens
Ligand Alpha-MSH
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3
Date 2021-11-03
D.O.I. 10.1038/s41422-021-00552-3
Net Summary
Imin 3.22
Number of Linked Nodes 849
Number of Links 1004
Number of Hubs 147
Number of Links mediated by Hubs 551
Number of Communities 33
Number of Nodes involved in Communities 223
Number of Links involved in Communities 306
Path Summary
Number Of Nodes in MetaPath 169
Number Of Links MetaPath 168
Number of Shortest Paths 1140492
Length Of Smallest Path 3
Average Path Length 30.1469
Length of Longest Path 64
Minimum Path Strength 1.25
Average Path Strength 7.28857
Maximum Path Strength 22.26
Minimum Path Correlation 0.7
Average Path Correlation 0.978546
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 44.6125
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.7188
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7F53_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKNT 
IVKQMSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSQT NRLQAALKL FDSIWNNKW LRDTSVILF LNKQDLLAE 
KVLAKIEDY FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR 
ISTASGDGR HYCYPHFTC AVDTENIRR VFNDCRDII QRMHLRQYE 
LL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7F53_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7F53_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32245
Sequence
>7F53_Chain_R
GCYEQLFVS PEVFVTLGV ISLLENILV IVAIAKNKN LHSPMYFFI 
CSLAVADML VSVSNGSET IVITLLNST SFTVNIDNV IDSVICSSL 
LASICSLLS IAVDRYFTI FYALQYHNI MTVKRVGII ISCIWAACT 
VSGILFIIY SDSSAVIIC LITMFFTML ALMASLYVH MFLMARLHI 
KRIAVLPGT QGANMKGAI TLTILIGVF VVCWAPFFL HLIFYISCP 
QNPYCVCFM SHFNLYLIL IMCNSIIDP LIYALRSQE LRKTFKEII 
CCY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
mc4_on7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
7F58-MC4-THIQ-Gs/&β;1/&γ;2
7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
gs_melanocortin7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
7F58-MC4-THIQ-Gs/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W25APeptideMelanocortinMC4Homo sapiensSHU9119Ca-2.752020-04-2910.1126/science.aaz8995
7AUEAPeptideMelanocortinMC4Homo sapiensSetmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;22.972021-04-2810.1126/science.abf7958
7F54APeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/&β;1/&γ;232021-11-0310.1038/s41422-021-00552-3
7F55APeptideMelanocortinMC4Homo sapiensBremelanotide-Gs/&β;1/&γ;23.12021-11-0310.1038/s41422-021-00552-3
7F58APeptideMelanocortinMC4Homo sapiensTHIQ-Gs/&β;1/&γ;23.12021-11-0310.1038/s41422-021-00552-3
7PIUAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/&β;1/&γ;22.582021-11-1710.1038/s41422-021-00569-8
7PIVAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/&β;1/&γ;22.862021-11-1710.1038/s41422-021-00569-8




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