psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	L:L:S3	8.45	Yes	No	0	0	0
2	L:L:?4	L:L:E5	11.18	Yes	No	0	0	0
3	L:L:?4	R:R:E100	7.46	Yes	Yes	1	0	5
4	L:L:?4	R:R:I104	13.38	Yes	No	0	0	4
5	L:L:?4	R:R:D122	22.91	Yes	No	1	0	8
6	L:L:H6	R:R:N285	12.75	No	No	0	0	4
7	L:L:?7	L:L:R8	11.32	Yes	Yes	1	0	0
8	L:L:?7	L:L:W9	3.86	Yes	Yes	1	0	0
9	L:L:?7	R:R:E100	5.61	Yes	Yes	1	0	5
10	L:L:?7	R:R:D126	11.5	Yes	Yes	1	0	4
11	L:L:?7	R:R:I129	12.09	Yes	No	0	0	5
12	L:L:?7	R:R:F261	5.16	Yes	Yes	1	0	5
13	L:L:?7	R:R:F284	6.19	Yes	Yes	1	0	3
14	L:L:R8	L:L:W9	9	Yes	Yes	1	0	0
15	L:L:R8	R:R:D126	10.72	Yes	Yes	1	0	4
16	L:L:R8	R:R:I185	8.77	Yes	Yes	1	0	5
17	L:L:R8	R:R:S188	11.86	Yes	No	0	0	4
18	L:L:W9	R:R:I194	11.74	Yes	No	1	0	4
19	L:L:W9	R:R:L197	3.42	Yes	No	0	0	5
20	L:L:W9	R:R:L265	4.56	Yes	No	1	0	5
21	L:L:W9	R:R:Y268	16.4	Yes	No	0	0	5
22	L:L:G10	R:R:F284	6.02	No	Yes	0	0	3
23	L:L:K11	R:R:Q43	8.14	No	No	0	0	3
24	L:L:P12	R:R:P272	3.9	No	No	0	0	3
25	L:L:P12	R:R:M281	3.35	No	No	0	0	3
26	R:R:C279	R:R:C40	7.28	No	No	0	4	2
27	R:R:E42	R:R:Y41	6.73	No	No	0	3	6
28	R:R:F284	R:R:Q43	3.51	Yes	No	0	3	3
29	R:R:I289	R:R:V46	4.61	Yes	Yes	0	5	5
30	R:R:P48	R:R:T105	3.5	Yes	No	0	5	4
31	R:R:F51	R:R:T101	7.78	No	Yes	0	6	6
32	R:R:F51	R:R:I289	6.28	No	Yes	0	6	5
33	R:R:F51	R:R:M292	7.46	No	No	0	6	5
34	R:R:I102	R:R:V52	4.61	No	No	0	6	4
35	R:R:I289	R:R:L54	4.28	Yes	No	0	5	6
36	R:R:L54	R:R:M292	5.65	No	No	0	6	5
37	R:R:G55	R:R:S94	3.71	No	No	0	6	8
38	R:R:I296	R:R:I57	4.42	No	No	0	6	5
39	R:R:S58	R:R:S94	6.52	No	No	0	8	8
40	R:R:I63	R:R:L59	4.28	No	No	0	4	6
41	R:R:E61	R:R:I296	6.83	No	No	0	8	6
42	R:R:A87	R:R:N62	4.69	No	No	0	9	9
43	R:R:D90	R:R:N62	8.08	Yes	No	0	9	9
44	R:R:A87	R:R:V65	3.39	No	Yes	0	9	9
45	R:R:A303	R:R:V65	3.39	No	Yes	0	8	9
46	R:R:F313	R:R:V65	6.55	Yes	Yes	0	6	9
47	R:R:K71	R:R:V67	6.07	No	No	0	5	4
48	R:R:A68	R:R:T312	3.36	No	No	0	7	7
49	R:R:I69	R:R:Y80	3.63	No	Yes	2	8	8
50	R:R:I69	R:R:L309	4.28	No	No	2	8	8
51	R:R:N72	R:R:N74	6.81	No	No	0	7	6
52	R:R:L75	R:R:N72	12.36	Yes	No	0	9	7
53	R:R:N72	R:R:T312	5.85	No	No	0	7	7
54	R:R:H76	R:R:K73	3.93	No	No	0	8	5
55	R:R:L75	R:R:Y80	10.55	Yes	Yes	2	9	8
56	R:R:E308	R:R:L75	6.63	No	Yes	2	6	9
57	R:R:L309	R:R:L75	4.15	No	Yes	2	8	9
58	R:R:F81	R:R:H76	4.53	No	No	0	4	8
59	R:R:S77	R:R:Y80	6.36	No	Yes	0	7	8
60	R:R:M161	R:R:P78	3.35	Yes	No	0	7	6
61	R:R:P78	R:R:V166	3.53	No	No	0	6	7
62	R:R:D146	R:R:M79	4.16	No	No	0	9	8
63	R:R:S306	R:R:Y80	7.63	No	Yes	2	7	8
64	R:R:E308	R:R:Y80	4.49	No	Yes	2	6	8
65	R:R:L309	R:R:Y80	3.52	No	Yes	2	8	8
66	R:R:F81	R:R:V166	3.93	No	No	0	4	7
67	R:R:F82	R:R:S142	6.61	No	No	0	8	7
68	R:R:D146	R:R:F82	9.55	No	No	0	9	8
69	R:R:F82	R:R:I170	5.02	No	No	0	8	7
70	R:R:S139	R:R:S85	4.89	No	No	0	8	9
71	R:R:S85	R:R:W174	4.94	No	Yes	0	9	9
72	R:R:D90	R:R:L86	5.43	Yes	Yes	0	9	9
73	R:R:L86	R:R:S139	4.5	Yes	No	0	9	8
74	R:R:L140	R:R:L86	5.54	No	Yes	3	8	9
75	R:R:D298	R:R:L86	4.07	Yes	Yes	3	9	9
76	R:R:V88	R:R:W174	3.68	No	Yes	0	6	9
77	R:R:D90	R:R:S136	4.42	Yes	No	0	9	9
78	R:R:D90	R:R:S295	8.83	Yes	No	0	9	9
79	R:R:L92	R:R:S132	6.01	No	No	0	6	6
80	R:R:S132	R:R:V93	4.85	No	No	0	6	8
81	R:R:L133	R:R:V93	5.96	No	No	0	5	8
82	R:R:S295	R:R:V93	4.85	No	No	0	9	8
83	R:R:S96	R:R:V128	4.85	No	No	0	6	4
84	R:R:I129	R:R:S96	6.19	No	No	0	5	6
85	R:R:I129	R:R:N97	14.16	No	No	0	5	6
86	R:R:G98	R:R:T101	3.64	No	Yes	0	6	6
87	R:R:D122	R:R:E100	3.9	No	Yes	1	8	5
88	R:R:E100	R:R:I125	9.56	Yes	No	0	5	5
89	R:R:D126	R:R:E100	7.8	Yes	Yes	1	4	5
90	R:R:F117	R:R:S116	3.96	No	No	0	5	3
91	R:R:D122	R:R:D126	6.65	No	Yes	1	8	4
92	R:R:I185	R:R:N123	4.25	Yes	No	0	5	5
93	R:R:D126	R:R:I185	4.2	Yes	Yes	1	4	5
94	R:R:I185	R:R:S127	9.29	Yes	No	0	5	5
95	R:R:C130	R:R:G181	3.92	No	No	0	4	6
96	R:R:C130	R:R:F184	4.19	No	Yes	0	4	4
97	R:R:L133	R:R:W258	3.42	No	Yes	0	5	7
98	R:R:A135	R:R:W174	7.78	No	Yes	0	7	9
99	R:R:A135	R:R:C177	3.61	No	No	0	7	7
100	R:R:S136	R:R:W258	4.94	No	Yes	0	9	7
101	R:R:I137	R:R:M204	5.83	No	No	0	6	6
102	R:R:I137	R:R:W258	3.52	No	Yes	0	6	7
103	R:R:C138	R:R:C177	3.64	No	No	0	5	7
104	R:R:D298	R:R:L140	5.43	Yes	No	3	9	8
105	R:R:L140	R:R:Y302	4.69	No	Yes	3	8	9
106	R:R:L141	R:R:M204	4.24	No	No	0	7	6
107	R:R:L141	R:R:L207	4.15	No	No	0	7	5
108	R:R:I143	R:R:Y302	6.04	No	Yes	0	9	9
109	R:R:A144	R:R:Y212	5.34	No	Yes	0	9	9
110	R:R:D146	R:R:Y157	5.75	No	Yes	0	9	9
111	R:R:R147	R:R:Y212	4.12	No	Yes	0	9	9
112	R:R:R147	R:R:Y302	6.17	No	Yes	0	9	9
113	R:R:F152	R:R:Y148	25.79	Yes	Yes	4	6	8
114	R:R:L211	R:R:Y148	9.38	No	Yes	0	7	8
115	R:R:H214	R:R:Y148	9.8	No	Yes	4	4	8
116	R:R:M215	R:R:Y148	3.59	No	Yes	0	9	8
117	R:R:F149	R:R:Y153	6.19	No	No	0	6	6
118	R:R:F149	R:R:M161	6.22	No	Yes	0	6	7
119	R:R:I151	R:R:T150	4.56	No	No	0	8	8
120	R:R:T150	R:R:Y157	16.23	No	Yes	0	8	9
121	R:R:F152	R:R:I151	6.28	Yes	No	0	6	8
122	R:R:I151	R:R:M215	4.37	No	No	0	8	9
123	R:R:F152	R:R:H214	14.71	Yes	No	4	6	4
124	R:R:H158	R:R:Y157	7.62	No	Yes	0	6	9
125	R:R:M161	R:R:Y157	8.38	Yes	Yes	0	7	9
126	R:R:F184	R:R:S180	3.96	Yes	No	0	4	4
127	R:R:F184	R:R:V193	7.87	Yes	No	0	4	5
128	R:R:F184	R:R:L197	4.87	Yes	No	0	4	5
129	R:R:I186	R:R:Y187	7.25	No	No	0	4	4
130	R:R:D189	R:R:S188	4.42	No	No	0	5	4
131	R:R:I194	R:R:L265	7.14	No	No	1	4	5
132	R:R:I194	R:R:I269	5.89	No	No	0	4	4
133	R:R:I198	R:R:I266	4.42	No	No	0	5	5
134	R:R:F201	R:R:F202	7.5	Yes	No	0	6	4
135	R:R:F201	R:R:W258	4.01	Yes	Yes	0	6	7
136	R:R:F201	R:R:F262	31.08	Yes	No	0	6	5
137	R:R:F202	R:R:I266	3.77	No	No	0	4	5
138	R:R:F254	R:R:L205	4.87	No	No	0	8	6
139	R:R:L205	R:R:V255	4.47	No	No	0	6	5
140	R:R:M208	R:R:Y212	5.99	No	Yes	0	8	9
141	R:R:F254	R:R:M208	4.98	No	No	0	8	8
142	R:R:M215	R:R:Y212	3.59	No	Yes	0	9	9
143	R:R:L250	R:R:Y212	5.86	Yes	Yes	0	8	9
144	R:R:F216	R:R:L247	12.18	No	No	0	6	8
145	R:R:L217	R:R:R220	3.64	No	No	0	4	5
146	R:R:L221	R:R:M218	5.65	No	No	0	5	5
147	R:R:H222	R:R:M218	6.57	No	No	0	7	5
148	R:R:K224	R:R:R220	4.95	No	No	0	5	5
149	R:R:H222	R:R:R225	6.77	No	No	0	7	5
150	R:R:I223	R:R:N240	9.91	No	No	0	5	7
151	R:R:G243	R:R:T246	3.64	No	No	0	8	9
152	R:R:I301	R:R:L250	4.28	No	Yes	3	9	8
153	R:R:L250	R:R:Y302	4.69	Yes	Yes	3	8	9
154	R:R:F254	R:R:W258	11.02	No	Yes	0	8	7
155	R:R:C257	R:R:N294	7.87	No	No	0	8	9
156	R:R:I291	R:R:W258	10.57	No	Yes	0	6	7
157	R:R:N294	R:R:W258	9.04	No	Yes	0	9	7
158	R:R:P260	R:R:Y287	6.95	No	Yes	0	9	5
159	R:R:F261	R:R:F262	5.36	Yes	No	0	5	5
160	R:R:F261	R:R:L265	4.87	Yes	No	1	5	5
161	R:R:F261	R:R:F284	6.43	Yes	Yes	1	5	3
162	R:R:F261	R:R:I291	6.28	Yes	No	0	5	6
163	R:R:F280	R:R:L263	3.65	No	No	0	2	5
164	R:R:H264	R:R:M281	6.57	No	No	0	4	3
165	R:R:F284	R:R:H264	10.18	Yes	No	0	3	4
166	R:R:H264	R:R:Y287	5.44	No	Yes	0	4	5
167	R:R:C271	R:R:F267	5.59	No	No	5	5	4
168	R:R:C277	R:R:F267	5.59	No	No	5	6	4
169	R:R:F267	R:R:F280	11.79	No	No	0	4	2
170	R:R:C271	R:R:S270	5.16	No	No	0	5	4
171	R:R:C271	R:R:C277	7.28	No	No	5	5	6
172	R:R:P272	R:R:Q273	4.74	No	No	0	3	1
173	R:R:N274	R:R:P275	9.77	No	No	0	4	4
174	R:R:C277	R:R:N274	7.87	No	No	0	6	4
175	R:R:F280	R:R:Y287	14.44	No	Yes	0	2	5
176	R:R:H283	R:R:S282	4.18	No	No	0	4	1
177	R:R:H283	R:R:Y287	7.62	No	Yes	0	4	5
178	R:R:F284	R:R:L288	13.4	Yes	No	0	3	4
179	R:R:D298	R:R:N294	13.46	Yes	No	0	9	9
180	R:R:D298	R:R:I301	4.2	Yes	No	3	9	9
181	R:R:I301	R:R:Y302	6.04	No	Yes	3	9	9
182	R:R:F313	R:R:L304	4.87	Yes	No	0	6	6
183	R:R:R305	R:R:R310	4.26	No	No	0	8	8
184	R:R:E308	R:R:S306	4.31	No	No	2	6	7
185	R:R:C319	R:R:Y320	4.03	No	No	0	9	4
186	R:R:L229	R:R:P230	3.28	No	No	0	4	2
187	R:R:L290	R:R:P260	3.28	No	No	0	7	9
188	R:R:C84	R:R:I66	3.27	No	No	0	5	7
189	R:R:C138	R:R:I173	3.27	No	No	0	5	5
190	R:R:S295	R:R:S94	3.26	No	No	0	9	8
191	R:R:A87	R:R:I66	3.25	No	No	0	9	7
192	R:R:A239	R:R:I223	3.25	No	No	0	6	5
193	R:R:V46	R:R:V50	3.21	Yes	No	0	5	4
194	R:R:C293	R:R:L54	3.17	No	No	0	4	6
195	R:R:C177	R:R:L134	3.17	No	No	0	7	5
196	R:R:I296	R:R:S58	3.1	No	No	0	6	8
197	R:R:I316	R:R:V67	3.07	No	No	0	7	4
198	R:R:I57	R:R:T53	3.04	No	No	0	5	3
199	R:R:I182	R:R:T178	3.04	No	No	0	3	3
200	R:R:I316	R:R:T312	3.04	No	No	0	7	7
201	R:R:F216	R:R:G243	3.01	No	No	0	6	8
202	R:R:L44	R:R:V46	2.98	No	Yes	0	2	5
203	R:R:L141	R:R:V145	2.98	No	No	0	7	7
204	R:R:L211	R:R:V145	2.98	No	No	0	7	7
205	R:R:N285	R:R:V46	2.96	No	Yes	0	4	5
206	R:R:N120	R:R:V119	2.96	No	No	0	1	3
207	R:R:L229	R:R:T232	2.95	No	No	0	4	4
208	R:R:L250	R:R:T246	2.95	Yes	No	0	8	9
209	R:R:I69	R:R:I83	2.94	No	No	0	8	8
210	R:R:I121	R:R:I125	2.94	No	No	0	4	5
211	R:R:I169	R:R:I173	2.94	No	No	0	5	5
212	R:R:I182	R:R:I186	2.94	No	No	0	3	4
213	R:R:I195	R:R:I269	2.94	No	No	0	4	4
214	R:R:I245	R:R:I249	2.94	No	No	0	7	7
215	R:R:I63	R:R:M91	2.92	No	No	0	4	7
216	R:R:I160	R:R:M161	2.92	No	Yes	0	5	7
217	R:R:I168	R:R:K164	2.91	No	No	0	3	4
218	R:R:F45	R:R:P48	2.89	No	Yes	0	3	5
219	R:R:E49	R:R:S47	2.87	No	No	0	3	4
220	R:R:K224	R:R:L221	2.82	No	No	0	5	5
221	R:R:M91	R:R:N62	2.8	No	No	0	7	9
222	R:R:C196	R:R:F184	2.79	No	Yes	0	5	4
223	R:R:L60	R:R:L64	2.77	No	No	0	4	7
224	R:R:A68	R:R:F313	2.77	No	Yes	0	7	6
225	R:R:A259	R:R:F201	2.77	No	Yes	0	4	6
226	R:R:A244	R:R:F216	2.77	No	No	0	8	6
227	R:R:M241	R:R:Q237	2.72	No	No	0	4	3
228	R:R:L155	R:R:Q156	2.66	No	No	0	8	6
229	R:R:A89	R:R:W174	2.59	No	Yes	0	8	9
230	R:R:H283	R:R:L44	2.57	No	No	0	4	2
231	R:R:F152	R:R:M218	2.49	Yes	No	0	6	5
232	R:R:F184	R:R:M200	2.49	Yes	No	0	4	4
233	R:R:F313	R:R:L64	2.44	Yes	No	0	6	7
234	R:R:N274	R:R:Y276	2.33	No	No	0	4	3
235	R:R:Q156	R:R:Y153	2.25	No	No	0	6	6
236	R:R:G181	R:R:S131	1.86	No	No	0	6	4
237	R:R:G167	R:R:V166	1.84	No	No	0	1	7
238	R:R:G231	R:R:T232	1.82	No	No	0	2	4
239	R:R:P48	R:R:S47	1.78	Yes	No	0	5	4
240	R:R:P299	R:R:V65	1.77	No	Yes	0	9	9
241	R:R:P48	R:R:T101	1.75	Yes	Yes	0	5	6
242	R:R:G243	R:R:K242	1.74	No	No	0	8	8
243	R:R:A192	R:R:S190	1.71	No	No	0	5	4
244	R:R:C257	R:R:V253	1.71	No	No	0	8	6
245	R:R:G238	R:R:Q237	1.64	No	No	0	4	3
246	R:R:S99	R:R:V103	1.62	No	No	0	6	3
247	R:R:A209	R:R:I251	1.62	No	No	0	5	7
248	R:R:V52	R:R:V56	1.6	No	No	0	4	4
249	R:R:S131	R:R:T178	1.6	No	No	0	4	3
250	R:R:T101	R:R:V52	1.59	Yes	No	0	6	4
251	R:R:T118	R:R:V119	1.59	No	No	0	6	3
252	R:R:T199	R:R:T203	1.57	No	No	0	4	4
253	R:R:I121	R:R:V103	1.54	No	No	0	4	3
254	R:R:I249	R:R:V253	1.54	No	No	0	7	6
255	R:R:I251	R:R:V255	1.54	No	No	0	7	5
256	R:R:I297	R:R:V253	1.54	No	No	0	7	6
257	R:R:M91	R:R:V95	1.52	No	No	0	7	5
258	R:R:I195	R:R:T199	1.52	No	No	0	4	4
259	R:R:I198	R:R:T199	1.52	No	No	0	5	4
260	R:R:K164	R:R:T162	1.5	No	No	0	4	8
261	R:R:L183	R:R:V179	1.49	No	No	0	5	3
262	R:R:L217	R:R:V213	1.49	No	No	0	4	3
263	R:R:L107	R:R:T118	1.47	No	No	0	4	6
264	R:R:I245	R:R:M241	1.46	No	No	0	7	4
265	R:R:I317	R:R:L64	1.43	No	No	0	5	7
266	R:R:I102	R:R:L106	1.43	No	No	0	6	4
267	R:R:I182	R:R:L183	1.43	No	No	0	3	5
268	R:R:I289	R:R:L286	1.43	Yes	No	0	5	2
269	R:R:E61	R:R:L300	1.33	No	No	0	8	6
270	R:R:F81	R:R:V163	1.31	No	No	0	4	2
271	L:L:S1	L:L:Y2	1.27	No	No	0	0	0
272	L:L:Y2	R:R:V119	1.26	No	No	0	0	3
273	L:L:V13	R:R:Y268	1.26	No	No	0	0	5
274	R:R:N240	R:R:R220	1.21	No	No	0	7	5
275	R:R:L304	R:R:R310	1.21	No	No	0	6	8
276	R:R:I316	R:R:Y320	1.21	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?4	12.676	5	1	0
2	L:L:?7	7.96143	7	1	0
3	L:L:R8	10.334	5	1	0
4	L:L:W9	8.16333	6	1	0
5	R:R:V46	3.44	4	0	5
6	R:R:P48	2.48	4	0	5
7	R:R:V65	3.775	4	0	9
8	R:R:L75	8.4225	4	2	9
9	R:R:Y80	6.03	6	2	8
10	R:R:L86	4.885	4	3	9
11	R:R:D90	6.69	4	0	9
12	R:R:E100	6.866	5	1	5
13	R:R:T101	3.69	4	0	6
14	R:R:D126	8.174	5	1	4
15	R:R:Y148	12.14	4	4	8
16	R:R:F152	12.3175	4	4	6
17	R:R:Y157	9.495	4	0	9
18	R:R:M161	5.2175	4	0	7
19	R:R:W174	4.7475	4	0	9
20	R:R:F184	4.36167	6	0	4
21	R:R:I185	6.6275	4	1	5
22	R:R:F201	11.34	4	0	6
23	R:R:Y212	4.98	5	0	9
24	R:R:L250	4.445	4	3	8
25	R:R:W258	6.64571	7	0	7
26	R:R:F261	5.62	5	1	5
27	R:R:F284	7.62167	6	1	3
28	R:R:Y287	8.6125	4	0	5
29	R:R:I289	4.15	4	0	5
30	R:R:D298	6.79	4	3	9
31	R:R:Y302	5.526	5	3	9
32	R:R:F313	4.1575	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?7	R:R:E100	12.7394	5.61	Yes	Yes	1	0	5
2	L:L:?7	R:R:F284	10.7617	6.19	Yes	Yes	1	0	3
3	R:R:F284	R:R:H264	50.2774	10.18	Yes	No	0	3	4
4	R:R:H264	R:R:Y287	45.227	5.44	No	Yes	0	4	5
5	R:R:H283	R:R:Y287	31.9714	7.62	No	Yes	0	4	5
6	R:R:H283	R:R:L44	29.6271	2.57	No	No	0	4	2
7	R:R:L44	R:R:V46	28.4405	2.98	No	Yes	0	2	5
8	L:L:?7	R:R:F261	39.7424	5.16	Yes	Yes	1	0	5
9	R:R:F261	R:R:L265	21.3256	4.87	Yes	No	1	5	5
10	L:L:?7	L:L:W9	23.2984	3.86	Yes	Yes	1	0	0
11	R:R:I289	R:R:V46	23.6988	4.61	Yes	Yes	0	5	5
12	R:R:F51	R:R:I289	17.3556	6.28	No	Yes	0	6	5
13	R:R:F51	R:R:T101	14.9052	7.78	No	Yes	0	6	6
14	R:R:F261	R:R:I291	99.6575	6.28	Yes	No	0	5	6
15	R:R:I291	R:R:W258	100	10.57	No	Yes	0	6	7
16	R:R:L133	R:R:W258	13.024	3.42	No	Yes	0	5	7
17	R:R:L133	R:R:V93	11.9628	5.96	No	No	0	5	8
18	R:R:S295	R:R:V93	10.0092	4.85	No	No	0	9	8
19	R:R:S295	R:R:S94	24.4224	3.26	No	No	0	9	8
20	R:R:S136	R:R:W258	54.7779	4.94	No	Yes	0	9	7
21	R:R:D90	R:R:S136	54.1267	4.42	Yes	No	0	9	9
22	R:R:D90	R:R:S295	19.9942	8.83	Yes	No	0	9	9
23	R:R:S58	R:R:S94	18.3735	6.52	No	No	0	8	8
24	R:R:I296	R:R:S58	15.3345	3.1	No	No	0	6	8
25	R:R:D90	R:R:N62	74.5984	8.08	Yes	No	0	9	9
26	R:R:A87	R:R:N62	65.5781	4.69	No	No	0	9	9
27	R:R:A87	R:R:V65	60.0502	3.39	No	Yes	0	9	9
28	R:R:F313	R:R:V65	54.4354	6.55	Yes	Yes	0	6	9
29	R:R:A68	R:R:F313	40.9966	2.77	No	Yes	0	7	6
30	R:R:A68	R:R:T312	39.0382	3.36	No	No	0	7	7
31	R:R:I316	R:R:T312	10.6073	3.04	No	No	0	7	7
32	R:R:N72	R:R:T312	27.085	5.85	No	No	0	7	7
33	R:R:L75	R:R:N72	23.0235	12.36	Yes	No	0	9	7
34	R:R:L75	R:R:Y80	10.4867	10.55	Yes	Yes	2	9	8
35	R:R:F254	R:R:W258	59.6739	11.02	No	Yes	0	8	7
36	R:R:F254	R:R:M208	55.7667	4.98	No	No	0	8	8
37	R:R:M208	R:R:Y212	55.1638	5.99	No	Yes	0	8	9
38	R:R:M215	R:R:Y212	96.9997	3.59	No	Yes	0	9	9
39	R:R:I151	R:R:M215	67.7777	4.37	No	No	0	8	9
40	R:R:I151	R:R:T150	44.2622	4.56	No	No	0	8	8
41	R:R:T150	R:R:Y157	42.2507	16.23	No	Yes	0	8	9
42	R:R:M161	R:R:Y157	27.9002	8.38	Yes	Yes	0	7	9
43	R:R:M161	R:R:P78	15.2236	3.35	Yes	No	0	7	6
44	R:R:P78	R:R:V166	13.077	3.53	No	No	0	6	7
45	R:R:D146	R:R:Y157	10.9208	5.75	No	Yes	0	9	9
46	R:R:D90	R:R:L86	53.5189	5.43	Yes	Yes	0	9	9
47	R:R:L86	R:R:S139	27.3745	4.5	Yes	No	0	9	8
48	R:R:N294	R:R:W258	27.6639	9.04	No	Yes	0	9	7
49	R:R:D298	R:R:N294	22.3241	13.46	Yes	No	0	9	9
50	R:R:D298	R:R:L86	28.1848	4.07	Yes	Yes	3	9	9
51	R:R:S139	R:R:S85	24.9337	4.89	No	No	0	8	9
52	R:R:S85	R:R:W174	22.4832	4.94	No	Yes	0	9	9
53	L:L:W9	R:R:L197	33.0182	3.42	Yes	No	0	0	5
54	R:R:F184	R:R:L197	30.944	4.87	Yes	No	0	4	5
55	R:R:C130	R:R:F184	20.1823	4.19	No	Yes	0	4	4
56	R:R:C130	R:R:G181	17.9779	3.92	No	No	0	4	6
57	R:R:A135	R:R:W174	15.074	7.78	No	Yes	0	7	9
58	R:R:A135	R:R:C177	12.585	3.61	No	No	0	7	7
59	R:R:L140	R:R:Y302	34.8078	4.69	No	Yes	3	8	9
60	R:R:D298	R:R:I301	26.6413	4.2	Yes	No	3	9	9
61	R:R:R147	R:R:Y212	16.579	4.12	No	Yes	0	9	9
62	R:R:M215	R:R:Y148	28.7444	3.59	No	Yes	0	9	8
63	R:R:F152	R:R:Y148	24.6684	25.79	Yes	Yes	4	6	8
64	R:R:F152	R:R:I151	25.6428	6.28	Yes	No	0	6	8
65	R:R:G181	R:R:S131	15.7638	1.86	No	No	0	6	4
66	R:R:S131	R:R:T178	13.5401	1.6	No	No	0	4	3
67	R:R:I182	R:R:T178	11.3067	3.04	No	No	0	3	3
68	R:R:L250	R:R:Y212	39.8871	5.86	Yes	Yes	0	8	9
69	R:R:I301	R:R:L250	24.5285	4.28	No	Yes	3	9	8
70	R:R:L250	R:R:T246	13.5015	2.95	Yes	No	0	8	9
71	R:R:G243	R:R:T246	11.2585	3.64	No	No	0	8	9
72	R:R:F152	R:R:M218	44.9375	2.49	Yes	No	0	6	5
73	R:R:L221	R:R:M218	32.7529	5.65	No	No	0	5	5
74	R:R:K224	R:R:L221	28.6672	2.82	No	No	0	5	5
75	R:R:K224	R:R:R220	24.5719	4.95	No	No	0	5	5
76	R:R:N240	R:R:R220	12.2232	1.21	No	No	0	7	5
77	R:R:C257	R:R:N294	14.582	7.87	No	No	0	8	9
78	R:R:F280	R:R:Y287	12.2377	14.44	No	Yes	0	2	5
79	R:R:C257	R:R:V253	12.7924	1.71	No	No	0	8	6
80	L:L:W9	R:R:L265	16.4295	4.56	Yes	No	1	0	5
81	R:R:F261	R:R:F284	44.0693	6.43	Yes	Yes	1	5	3
82	R:R:L140	R:R:L86	33.1436	5.54	No	Yes	3	8	9
83	R:R:R147	R:R:Y302	16.1546	6.17	No	Yes	0	9	9
84	R:R:L250	R:R:Y302	17.9876	4.69	Yes	Yes	3	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?4	R:R:E100	7.46	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:I104	13.38	1	Yes	No	0	4	0	1
L:L:?4	R:R:D122	22.91	1	Yes	No	0	8	0	1
L:L:H6	R:R:N285	12.75	0	No	No	0	4	0	1
L:L:?7	R:R:E100	5.61	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:D126	11.5	1	Yes	Yes	0	4	0	1
L:L:?7	R:R:I129	12.09	1	Yes	No	0	5	0	1
L:L:?7	R:R:F261	5.16	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:F284	6.19	1	Yes	Yes	0	3	0	1
L:L:R8	R:R:D126	10.72	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:I185	8.77	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:S188	11.86	1	Yes	No	0	4	0	1
L:L:W9	R:R:I194	11.74	1	Yes	No	0	4	0	1
L:L:W9	R:R:L197	3.42	1	Yes	No	0	5	0	1
L:L:W9	R:R:L265	4.56	1	Yes	No	0	5	0	1
L:L:W9	R:R:Y268	16.4	1	Yes	No	0	5	0	1
L:L:G10	R:R:F284	6.02	0	No	Yes	0	3	0	1
L:L:K11	R:R:Q43	8.14	0	No	No	0	3	0	1
L:L:P12	R:R:P272	3.9	0	No	No	0	3	0	1
L:L:P12	R:R:M281	3.35	0	No	No	0	3	0	1
R:R:F284	R:R:Q43	3.51	1	Yes	No	3	3	1	1
R:R:I129	R:R:S96	6.19	0	No	No	5	6	1	2
R:R:I129	R:R:N97	14.16	0	No	No	5	6	1	2
R:R:D122	R:R:E100	3.9	1	No	Yes	8	5	1	1
R:R:E100	R:R:I125	9.56	1	Yes	No	5	5	1	2
R:R:D126	R:R:E100	7.8	1	Yes	Yes	4	5	1	1
R:R:D122	R:R:D126	6.65	1	No	Yes	8	4	1	1
R:R:I185	R:R:N123	4.25	1	Yes	No	5	5	1	2
R:R:D126	R:R:I185	4.2	1	Yes	Yes	4	5	1	1
R:R:I185	R:R:S127	9.29	1	Yes	No	5	5	1	2
R:R:F184	R:R:L197	4.87	0	Yes	No	4	5	2	1
R:R:D189	R:R:S188	4.42	0	No	No	5	4	2	1
R:R:I194	R:R:L265	7.14	1	No	No	4	5	1	1
R:R:I194	R:R:I269	5.89	1	No	No	4	4	1	2
R:R:F261	R:R:F262	5.36	1	Yes	No	5	5	1	2
R:R:F261	R:R:L265	4.87	1	Yes	No	5	5	1	1
R:R:F261	R:R:F284	6.43	1	Yes	Yes	5	3	1	1
R:R:F261	R:R:I291	6.28	1	Yes	No	5	6	1	2
R:R:H264	R:R:M281	6.57	0	No	No	4	3	2	1
R:R:F284	R:R:H264	10.18	1	Yes	No	3	4	1	2
R:R:P272	R:R:Q273	4.74	0	No	No	3	1	1	2
R:R:F284	R:R:L288	13.4	1	Yes	No	3	4	1	2
R:R:N285	R:R:V46	2.96	0	No	Yes	4	5	1	2
R:R:N120	R:R:V119	2.96	0	No	No	1	3	2	1
R:R:T118	R:R:V119	1.59	0	No	No	6	3	2	1
L:L:Y2	R:R:V119	1.26	0	No	No	0	3	0	1
L:L:V13	R:R:Y268	1.26	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F54_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	257
Number of Links	276
Number of Hubs	32
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	30
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	49795
Length Of Smallest Path	3
Average Path Length	14.2409
Length of Longest Path	28
Minimum Path Strength	1.265
Average Path Strength	5.8881
Maximum Path Strength	19.29
Minimum Path Correlation	0.7
Average Path Correlation	0.936855
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	52.9097
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9371
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • ubiquitin protein ligase binding • protein binding • ubiquitin-like protein ligase binding • enzyme binding • melanocyte-stimulating hormone receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • regulation of behavior • behavior • regulation of eating behavior • multicellular organismal process • eating behavior • feeding behavior • regulation of feeding behavior • regulation of multicellular organismal process • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to insulin • response to oxygen-containing compound • response to nitrogen compound • homeostatic process • positive regulation of biological process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • positive regulation of multicellular organismal process • positive regulation of bone resorption • response to melanocyte-stimulating hormone • establishment of protein localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • intracellular protein localization • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • response to nutrient levels • response to food • cellular anatomical structure • membrane • cell periphery • plasma membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide signaling pathway • system process • circulatory system process • regulation of blood pressure • blood circulation • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of localization • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • regulation of secretion by cell • regulation of signaling • regulation of transport • lipid localization • endocrine process • regulation of lipid localization • regulation of cell communication • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • regulation of appetite • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • membrane-bounded organelle • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of protein localization • regulation of peptide secretion • regulation of peptide hormone secretion • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • regulation of protein secretion • regulation of insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32245
Sequence	>7F54_nogp_Chain_R G C Y E Q L F V S P E V F V T L G V I S L L E N I L V I V A I A K N K N L H S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L N S T S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y A L Q Y H N I M T V K R V G I I I S C I W A A C T V S G I L F I I Y S D S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L P G T Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C P Q N P Y C V C F M S H F N L Y L I L I M C N S I I D P L I Y A L R S Q E L R K T F K E I I C C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6W25	A	Peptide	Melanocortin	MC₄	Homo sapiens	SHU9119	Ca	-	2.75	2020-04-29	doi.org/10.1126/science.aaz8995
	7F53	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F53 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7PIU	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIU (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7AUE	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	chim(NtGi1L-Gs)/β1/γ2	2.97	2021-04-28	doi.org/10.1126/science.abf7958
	7AUE (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.97	2021-04-28	doi.org/10.1126/science.abf7958
	8WKY	A	Peptide	Melanocortin	MC₄	Homo sapiens	PG-934	-	-	2.9	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8WKZ	A	Peptide	Melanocortin	MC₄	Homo sapiens	SBL-MC-31	-	-	3.3	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8QJ2	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-	Gs	3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	8QJ2 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-		3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	9K3K	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3K (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-		3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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