psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y2	R:R:V119	6.31	Yes	No	0	0	3
2	L:L:Y2	R:R:D122	11.49	Yes	No	0	0	8
3	L:L:M4	R:R:E100	4.06	No	Yes	0	0	5
4	L:L:M4	R:R:I104	7.29	No	No	0	0	4
5	L:L:M4	R:R:D122	12.48	No	No	0	0	8
6	L:L:E5	L:L:K11	6.75	No	No	0	0	0
7	L:L:H6	R:R:F51	12.44	Yes	Yes	5	0	6
8	L:L:H6	R:R:T101	6.85	Yes	Yes	5	0	6
9	L:L:H6	R:R:N285	7.65	Yes	No	0	0	4
10	L:L:H6	R:R:L288	3.86	Yes	No	0	0	4
11	L:L:F7	L:L:R8	5.34	Yes	Yes	1	0	0
12	L:L:F7	L:L:W9	7.02	Yes	Yes	1	0	0
13	L:L:F7	R:R:D126	4.78	Yes	Yes	1	0	4
14	L:L:F7	R:R:I129	12.56	Yes	Yes	0	0	5
15	L:L:F7	R:R:C130	4.19	Yes	No	0	0	4
16	L:L:F7	R:R:L133	3.65	Yes	No	0	0	5
17	L:L:R8	L:L:W9	8	Yes	Yes	1	0	0
18	L:L:R8	R:R:N123	3.62	Yes	No	1	0	5
19	L:L:R8	R:R:D126	15.48	Yes	Yes	1	0	4
20	L:L:R8	R:R:I185	7.52	Yes	Yes	1	0	5
21	L:L:R8	R:R:S188	10.54	Yes	No	1	0	4
22	L:L:W9	R:R:S188	3.71	Yes	No	1	0	4
23	L:L:W9	R:R:I194	5.87	Yes	Yes	1	0	4
24	L:L:W9	R:R:L265	4.56	Yes	No	1	0	5
25	L:L:W9	R:R:Y268	11.58	Yes	No	1	0	5
26	L:L:G10	R:R:F284	10.54	No	Yes	0	0	3
27	L:L:K11	R:R:Q43	6.78	No	No	0	0	3
28	L:L:P12	R:R:M281	5.03	No	No	0	0	3
29	R:R:G39	R:R:Y41	5.79	No	No	0	3	6
30	R:R:C279	R:R:C40	7.28	No	No	0	4	2
31	R:R:E42	R:R:Y41	6.73	No	No	0	3	6
32	R:R:N285	R:R:V46	4.43	No	No	0	4	5
33	R:R:I289	R:R:V46	4.61	Yes	No	0	5	5
34	R:R:F51	R:R:T101	7.78	Yes	Yes	5	6	6
35	R:R:F51	R:R:I289	7.54	Yes	Yes	0	6	5
36	R:R:F51	R:R:M292	7.46	Yes	No	0	6	5
37	R:R:I102	R:R:V52	4.61	No	No	0	6	4
38	R:R:I289	R:R:L54	4.28	Yes	Yes	0	5	6
39	R:R:L54	R:R:M292	5.65	Yes	No	0	6	5
40	R:R:I296	R:R:L54	4.28	No	Yes	0	6	6
41	R:R:G55	R:R:S94	3.71	No	No	0	6	8
42	R:R:E61	R:R:I57	4.1	No	No	0	8	5
43	R:R:S58	R:R:S94	6.52	No	No	0	8	8
44	R:R:I296	R:R:S58	7.74	No	No	0	6	8
45	R:R:I63	R:R:L59	4.28	No	No	0	4	6
46	R:R:E61	R:R:I296	6.83	No	No	0	8	6
47	R:R:A87	R:R:N62	4.69	No	No	0	9	9
48	R:R:D90	R:R:N62	5.39	Yes	No	0	9	9
49	R:R:N62	R:R:P299	8.15	No	No	0	9	9
50	R:R:F313	R:R:L64	6.09	Yes	No	0	6	7
51	R:R:F313	R:R:V65	6.55	Yes	No	0	6	9
52	R:R:C84	R:R:I66	4.91	No	No	0	5	7
53	R:R:K71	R:R:V67	6.07	No	No	0	5	4
54	R:R:I69	R:R:Y80	3.63	No	Yes	0	8	8
55	R:R:I69	R:R:L309	5.71	No	No	0	8	8
56	R:R:K71	R:R:Y320	4.78	No	No	0	5	4
57	R:R:N72	R:R:N74	9.54	No	No	0	7	6
58	R:R:L75	R:R:N72	12.36	No	No	0	9	7
59	R:R:N72	R:R:T312	5.85	No	No	0	7	7
60	R:R:L75	R:R:Y80	9.38	No	Yes	3	9	8
61	R:R:E308	R:R:L75	6.63	No	No	3	6	9
62	R:R:F81	R:R:H76	5.66	No	No	0	4	8
63	R:R:S77	R:R:Y80	6.36	No	Yes	0	7	8
64	R:R:D146	R:R:M79	9.7	No	No	0	9	8
65	R:R:S306	R:R:Y80	7.63	No	Yes	3	7	8
66	R:R:E308	R:R:Y80	4.49	No	Yes	3	6	8
67	R:R:F81	R:R:V166	5.24	No	Yes	0	4	7
68	R:R:F82	R:R:S142	6.61	No	No	0	8	7
69	R:R:D146	R:R:F82	8.36	No	No	0	9	8
70	R:R:F82	R:R:I170	5.02	No	No	0	8	7
71	R:R:S139	R:R:S85	4.89	No	No	0	8	9
72	R:R:S85	R:R:W174	4.94	No	Yes	0	9	9
73	R:R:D90	R:R:L86	6.79	Yes	Yes	0	9	9
74	R:R:L86	R:R:S139	4.5	Yes	No	0	9	8
75	R:R:L140	R:R:L86	5.54	No	Yes	2	8	9
76	R:R:D298	R:R:L86	6.79	No	Yes	2	9	9
77	R:R:V88	R:R:W174	3.68	No	Yes	0	6	9
78	R:R:D90	R:R:S136	5.89	Yes	No	0	9	9
79	R:R:D90	R:R:S295	8.83	Yes	No	0	9	9
80	R:R:L92	R:R:S132	6.01	No	No	0	6	6
81	R:R:S132	R:R:V93	4.85	No	No	0	6	8
82	R:R:S295	R:R:V93	4.85	No	No	0	9	8
83	R:R:S96	R:R:V128	4.85	No	No	0	6	4
84	R:R:I129	R:R:S96	7.74	Yes	No	0	5	6
85	R:R:I129	R:R:N97	8.5	Yes	No	0	5	6
86	R:R:M292	R:R:N97	7.01	No	No	0	5	6
87	R:R:G98	R:R:T101	3.64	No	Yes	0	6	6
88	R:R:E100	R:R:I125	9.56	Yes	No	0	5	5
89	R:R:D126	R:R:E100	7.8	Yes	Yes	0	4	5
90	R:R:E100	R:R:I129	4.1	Yes	Yes	0	5	5
91	R:R:F117	R:R:S116	3.96	No	No	0	5	3
92	R:R:D122	R:R:D126	7.98	No	Yes	0	8	4
93	R:R:I185	R:R:N123	4.25	Yes	No	1	5	5
94	R:R:D126	R:R:I185	4.2	Yes	Yes	1	4	5
95	R:R:I185	R:R:S127	9.29	Yes	No	0	5	5
96	R:R:C130	R:R:G181	3.92	No	No	0	4	6
97	R:R:C130	R:R:F184	4.19	No	Yes	0	4	4
98	R:R:L133	R:R:W258	4.56	No	Yes	0	5	7
99	R:R:A135	R:R:W174	7.78	No	Yes	0	7	9
100	R:R:A135	R:R:C177	3.61	No	No	0	7	7
101	R:R:S136	R:R:W258	4.94	No	Yes	0	9	7
102	R:R:I137	R:R:M204	5.83	No	No	0	6	6
103	R:R:I137	R:R:W258	7.05	No	Yes	0	6	7
104	R:R:C138	R:R:C177	3.64	No	No	0	5	7
105	R:R:D298	R:R:L140	6.79	No	No	2	9	8
106	R:R:L140	R:R:Y302	4.69	No	Yes	2	8	9
107	R:R:L141	R:R:M204	4.24	No	No	0	7	6
108	R:R:L141	R:R:L207	4.15	No	No	0	7	5
109	R:R:I173	R:R:S142	4.64	No	No	0	5	7
110	R:R:I143	R:R:Y302	6.04	No	Yes	0	9	9
111	R:R:A144	R:R:Y212	5.34	No	Yes	0	9	9
112	R:R:D146	R:R:Y157	5.75	No	Yes	0	9	9
113	R:R:R147	R:R:Y302	6.17	No	Yes	0	9	9
114	R:R:F152	R:R:Y148	17.54	Yes	Yes	7	6	8
115	R:R:L211	R:R:Y148	10.55	No	Yes	0	7	8
116	R:R:H214	R:R:Y148	11.98	No	Yes	7	4	8
117	R:R:M215	R:R:Y148	4.79	No	Yes	0	9	8
118	R:R:F149	R:R:Y153	8.25	No	No	8	6	6
119	R:R:F149	R:R:I160	5.02	No	No	8	6	5
120	R:R:F149	R:R:M161	3.73	No	No	0	6	7
121	R:R:I151	R:R:T150	4.56	No	No	0	8	8
122	R:R:T150	R:R:Y157	9.99	No	Yes	0	8	9
123	R:R:F152	R:R:I151	7.54	Yes	No	0	6	8
124	R:R:I151	R:R:M215	4.37	No	No	0	8	9
125	R:R:F152	R:R:H214	14.71	Yes	No	7	6	4
126	R:R:I160	R:R:Y153	3.63	No	No	8	5	6
127	R:R:H158	R:R:Y157	7.62	No	Yes	0	6	9
128	R:R:M161	R:R:Y157	8.38	No	Yes	0	7	9
129	R:R:I168	R:R:K164	4.36	No	No	0	3	4
130	R:R:F184	R:R:V193	9.18	Yes	No	0	4	5
131	R:R:F184	R:R:L197	4.87	Yes	No	0	4	5
132	R:R:F184	R:R:M200	3.73	Yes	No	0	4	4
133	R:R:I186	R:R:Y187	7.25	No	No	0	4	4
134	R:R:D189	R:R:S188	4.42	No	No	0	5	4
135	R:R:I194	R:R:L265	7.14	Yes	No	1	4	5
136	R:R:I194	R:R:Y268	3.63	Yes	No	1	4	5
137	R:R:I194	R:R:I269	5.89	Yes	No	0	4	4
138	R:R:I195	R:R:I269	5.89	No	No	0	4	4
139	R:R:I198	R:R:I266	4.42	No	No	0	5	5
140	R:R:F201	R:R:F202	7.5	Yes	No	0	6	4
141	R:R:F201	R:R:L205	3.65	Yes	No	4	6	6
142	R:R:F201	R:R:F254	5.36	Yes	Yes	4	6	8
143	R:R:F201	R:R:W258	4.01	Yes	Yes	4	6	7
144	R:R:F201	R:R:F262	25.72	Yes	No	0	6	5
145	R:R:F202	R:R:I266	3.77	No	No	0	4	5
146	R:R:F254	R:R:L205	4.87	Yes	No	4	8	6
147	R:R:L205	R:R:V255	4.47	No	No	0	6	5
148	R:R:M208	R:R:Y212	4.79	No	Yes	0	8	9
149	R:R:F254	R:R:M208	4.98	Yes	No	0	8	8
150	R:R:M215	R:R:Y212	3.59	No	Yes	0	9	9
151	R:R:L250	R:R:Y212	5.86	Yes	Yes	2	8	9
152	R:R:Y212	R:R:Y302	3.97	Yes	Yes	2	9	9
153	R:R:F216	R:R:L247	9.74	Yes	No	0	6	8
154	R:R:L217	R:R:R220	4.86	No	No	0	4	5
155	R:R:L221	R:R:M218	7.07	No	No	0	5	5
156	R:R:H222	R:R:M218	6.57	No	No	0	7	5
157	R:R:K224	R:R:R220	4.95	No	No	0	5	5
158	R:R:L221	R:R:R225	4.86	No	No	0	5	5
159	R:R:H222	R:R:R225	6.77	No	No	0	7	5
160	R:R:A239	R:R:I223	4.87	No	No	0	6	5
161	R:R:I223	R:R:N240	8.5	No	No	0	5	7
162	R:R:L229	R:R:P230	4.93	No	No	0	4	2
163	R:R:G243	R:R:T246	3.64	No	No	0	8	9
164	R:R:I301	R:R:L250	4.28	No	Yes	2	9	8
165	R:R:L250	R:R:Y302	4.69	Yes	Yes	2	8	9
166	R:R:F254	R:R:W258	9.02	Yes	Yes	4	8	7
167	R:R:C257	R:R:N294	6.3	No	No	0	8	9
168	R:R:I291	R:R:W258	10.57	No	Yes	0	6	7
169	R:R:N294	R:R:W258	11.3	No	Yes	0	9	7
170	R:R:P260	R:R:Y287	4.17	No	Yes	0	9	5
171	R:R:F261	R:R:F262	5.36	Yes	No	0	5	5
172	R:R:F261	R:R:L265	3.65	Yes	No	0	5	5
173	R:R:F261	R:R:F284	6.43	Yes	Yes	0	5	3
174	R:R:F261	R:R:I291	5.02	Yes	No	0	5	6
175	R:R:F280	R:R:L263	3.65	No	No	0	2	5
176	R:R:H264	R:R:M281	6.57	No	No	0	4	3
177	R:R:F284	R:R:H264	10.18	Yes	No	0	3	4
178	R:R:H264	R:R:Y287	6.53	No	Yes	0	4	5
179	R:R:C271	R:R:F267	5.59	No	No	9	5	4
180	R:R:C277	R:R:F267	5.59	No	No	9	6	4
181	R:R:F267	R:R:F280	11.79	No	No	0	4	2
182	R:R:C271	R:R:S270	5.16	No	No	0	5	4
183	R:R:C271	R:R:C277	7.28	No	No	9	5	6
184	R:R:P272	R:R:Q273	6.32	No	No	0	3	1
185	R:R:N274	R:R:P275	9.77	No	No	0	4	4
186	R:R:C277	R:R:N274	7.87	No	No	0	6	4
187	R:R:F280	R:R:Y287	15.47	No	Yes	0	2	5
188	R:R:H283	R:R:Y287	7.62	No	Yes	0	4	5
189	R:R:F284	R:R:L288	13.4	Yes	No	0	3	4
190	R:R:D298	R:R:N294	13.46	No	No	0	9	9
191	R:R:I301	R:R:Y302	6.04	No	Yes	2	9	9
192	R:R:F313	R:R:L304	4.87	Yes	No	0	6	6
193	R:R:R305	R:R:R310	4.26	No	No	0	8	8
194	R:R:E308	R:R:S306	4.31	No	No	3	6	7
195	R:R:C319	R:R:Y320	4.03	No	No	0	9	4
196	R:R:P299	R:R:V65	3.53	No	No	0	9	9
197	R:R:P78	R:R:V166	3.53	No	Yes	0	6	7
198	R:R:F284	R:R:Q43	3.51	Yes	No	0	3	3
199	R:R:P48	R:R:T105	3.5	Yes	No	0	5	4
200	R:R:A303	R:R:V65	3.39	No	No	0	8	9
201	R:R:A68	R:R:T312	3.36	No	No	0	7	7
202	R:R:L290	R:R:P260	3.28	No	No	0	7	9
203	R:R:A87	R:R:I66	3.25	No	No	0	9	7
204	R:R:V46	R:R:V50	3.21	No	No	0	5	4
205	R:R:T101	R:R:V52	3.17	Yes	No	0	6	4
206	R:R:C293	R:R:L54	3.17	No	Yes	0	4	6
207	R:R:C177	R:R:L134	3.17	No	No	0	7	5
208	R:R:I316	R:R:V67	3.07	No	No	0	7	4
209	R:R:I170	R:R:V166	3.07	No	Yes	0	7	7
210	R:R:I57	R:R:T53	3.04	No	No	0	5	3
211	R:R:I182	R:R:T178	3.04	No	No	0	3	3
212	R:R:I316	R:R:T312	3.04	No	No	0	7	7
213	R:R:F216	R:R:G243	3.01	Yes	No	0	6	8
214	R:R:L141	R:R:V145	2.98	No	No	0	7	7
215	R:R:L211	R:R:V145	2.98	No	No	0	7	7
216	R:R:N120	R:R:V119	2.96	No	No	0	1	3
217	R:R:L250	R:R:T246	2.95	Yes	No	0	8	9
218	R:R:I69	R:R:I83	2.94	No	No	0	8	8
219	R:R:I121	R:R:I125	2.94	No	No	6	4	5
220	R:R:I169	R:R:I173	2.94	No	No	0	5	5
221	R:R:I182	R:R:I186	2.94	No	No	0	3	4
222	R:R:I245	R:R:I249	2.94	No	No	0	7	7
223	R:R:I63	R:R:M91	2.92	No	No	0	4	7
224	R:R:F45	R:R:P48	2.89	No	Yes	0	3	5
225	R:R:E49	R:R:S47	2.87	No	No	0	3	4
226	R:R:I102	R:R:L106	2.85	No	No	0	6	4
227	R:R:C196	R:R:F184	2.79	No	Yes	0	5	4
228	R:R:L60	R:R:L64	2.77	No	No	0	4	7
229	R:R:A68	R:R:F313	2.77	No	Yes	0	7	6
230	R:R:A259	R:R:F201	2.77	No	Yes	0	4	6
231	R:R:A244	R:R:F216	2.77	No	Yes	0	8	6
232	R:R:I160	R:R:Q156	2.74	No	No	0	5	6
233	R:R:L155	R:R:Q156	2.66	No	No	0	8	6
234	R:R:F184	R:R:S180	2.64	Yes	No	0	4	4
235	R:R:A89	R:R:W174	2.59	No	Yes	0	8	9
236	R:R:H283	R:R:L44	2.57	No	No	0	4	2
237	L:L:Y2	R:R:T118	2.5	Yes	No	0	0	6
238	R:R:F152	R:R:M218	2.49	Yes	No	0	6	5
239	R:R:F216	R:R:L217	2.44	Yes	No	0	6	4
240	R:R:L183	R:R:Y187	2.34	No	No	0	5	4
241	L:L:P12	R:R:P272	1.95	No	No	0	0	3
242	R:R:G181	R:R:S131	1.86	No	No	0	6	4
243	R:R:G167	R:R:V166	1.84	No	Yes	0	1	7
244	R:R:P48	R:R:S47	1.78	Yes	No	0	5	4
245	R:R:P48	R:R:T101	1.75	Yes	Yes	0	5	6
246	R:R:A192	R:R:S190	1.71	No	No	0	5	4
247	R:R:C257	R:R:V253	1.71	No	No	0	8	6
248	R:R:G238	R:R:Q237	1.64	No	No	0	4	3
249	R:R:S99	R:R:V103	1.62	No	No	0	6	3
250	R:R:A209	R:R:I251	1.62	No	No	0	5	7
251	R:R:V52	R:R:V56	1.6	No	No	0	4	4
252	R:R:S131	R:R:T178	1.6	No	No	0	4	3
253	R:R:T199	R:R:T203	1.57	No	No	0	4	4
254	R:R:I63	R:R:V67	1.54	No	No	0	4	4
255	R:R:I121	R:R:V103	1.54	No	No	6	4	3
256	R:R:I125	R:R:V103	1.54	No	No	6	5	3
257	R:R:I249	R:R:V253	1.54	No	No	0	7	6
258	R:R:I251	R:R:V255	1.54	No	No	0	7	5
259	R:R:I297	R:R:V253	1.54	No	No	0	7	6
260	R:R:M91	R:R:V95	1.52	No	No	0	7	5
261	R:R:I195	R:R:T199	1.52	No	No	0	4	4
262	R:R:I198	R:R:T199	1.52	No	No	0	5	4
263	R:R:L44	R:R:S282	1.5	No	No	0	2	1
264	R:R:K164	R:R:T162	1.5	No	No	0	4	8
265	R:R:L183	R:R:V179	1.49	No	No	0	5	3
266	R:R:L217	R:R:V213	1.49	No	No	0	4	3
267	R:R:L247	R:R:V213	1.49	No	No	0	8	3
268	R:R:L107	R:R:T118	1.47	No	No	0	4	6
269	R:R:L229	R:R:T232	1.47	No	No	0	4	4
270	R:R:C279	R:R:H283	1.47	No	No	0	4	4
271	R:R:I245	R:R:M241	1.46	No	No	0	7	4
272	R:R:I317	R:R:L64	1.43	No	No	0	5	7
273	R:R:I289	R:R:L286	1.43	Yes	No	0	5	2
274	R:R:K73	R:R:N74	1.4	No	No	0	5	6
275	R:R:I245	R:R:Q237	1.37	No	No	0	7	3
276	R:R:R165	R:R:T162	1.29	No	No	0	6	8
277	L:L:S1	L:L:Y2	1.27	No	Yes	0	0	0
278	L:L:V13	R:R:Y268	1.26	No	No	0	0	5
279	R:R:N240	R:R:R220	1.21	No	No	0	7	5
280	R:R:L304	R:R:R310	1.21	No	No	0	6	8
281	R:R:N274	R:R:Y276	1.16	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	5.3925	4	0	0
2	L:L:H6	7.7	4	5	0
3	L:L:F7	6.25667	6	1	0
4	L:L:R8	8.41667	6	1	0
5	L:L:W9	6.79	6	1	0
6	R:R:P48	2.48	4	0	5
7	R:R:F51	8.805	4	5	6
8	R:R:L54	4.345	4	0	6
9	R:R:Y80	6.298	5	3	8
10	R:R:L86	5.905	4	2	9
11	R:R:D90	6.725	4	0	9
12	R:R:E100	6.38	4	0	5
13	R:R:T101	4.638	5	5	6
14	R:R:D126	8.048	5	1	4
15	R:R:I129	8.225	4	0	5
16	R:R:Y148	11.215	4	7	8
17	R:R:F152	10.57	4	7	6
18	R:R:Y157	7.935	4	0	9
19	R:R:V166	3.42	4	0	7
20	R:R:W174	4.7475	4	0	9
21	R:R:F184	4.56667	6	0	4
22	R:R:I185	6.315	4	1	5
23	R:R:I194	5.6325	4	1	4
24	R:R:F201	8.16833	6	4	6
25	R:R:Y212	4.71	5	2	9
26	R:R:F216	4.49	4	0	6
27	R:R:L250	4.445	4	2	8
28	R:R:F254	6.0575	4	4	8
29	R:R:W258	7.35	7	4	7
30	R:R:F261	5.115	4	0	5
31	R:R:F284	8.812	5	0	3
32	R:R:Y287	8.4475	4	0	5
33	R:R:I289	4.465	4	0	5
34	R:R:Y302	5.26667	6	2	9
35	R:R:F313	5.07	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y2	R:R:D122	18.5973	11.49	Yes	No	0	0	8
2	L:L:M4	R:R:E100	10.4797	4.06	No	Yes	0	0	5
3	R:R:D122	R:R:D126	23.5084	7.98	No	Yes	0	8	4
4	R:R:D126	R:R:E100	17.7774	7.8	Yes	Yes	0	4	5
5	R:R:F261	R:R:F284	100	6.43	Yes	Yes	0	5	3
6	R:R:F261	R:R:L265	26.3171	3.65	Yes	No	0	5	5
7	L:L:W9	R:R:L265	17.7693	4.56	Yes	No	1	0	5
8	L:L:F7	L:L:W9	25.1319	7.02	Yes	Yes	1	0	0
9	L:L:F7	R:R:D126	35.3032	4.78	Yes	Yes	1	0	4
10	L:L:H6	R:R:F51	12.1682	12.44	Yes	Yes	5	0	6
11	R:R:F51	R:R:M292	17.0144	7.46	Yes	No	0	6	5
12	R:R:M292	R:R:N97	36.6182	7.01	No	No	0	5	6
13	R:R:I129	R:R:N97	38.0307	8.5	Yes	No	0	5	6
14	L:L:F7	R:R:I129	48.478	12.56	Yes	Yes	0	0	5
15	R:R:E100	R:R:I129	19.0762	4.1	Yes	Yes	0	5	5
16	R:R:F284	R:R:L288	44.3542	13.4	Yes	No	0	3	4
17	L:L:F7	R:R:C130	32.7786	4.19	Yes	No	0	0	4
18	L:L:F7	R:R:L133	95.9006	3.65	Yes	No	0	0	5
19	R:R:H264	R:R:M281	11.4863	6.57	No	No	0	4	3
20	R:R:F284	R:R:H264	60.4351	10.18	Yes	No	0	3	4
21	R:R:H264	R:R:Y287	47.4633	6.53	No	Yes	0	4	5
22	R:R:H283	R:R:Y287	14.4411	7.62	No	Yes	0	4	5
23	R:R:F51	R:R:I289	12.2981	7.54	Yes	Yes	0	6	5
24	R:R:L54	R:R:M292	24.7504	5.65	Yes	No	0	6	5
25	R:R:T101	R:R:V52	11.6487	3.17	Yes	No	0	6	4
26	R:R:I296	R:R:L54	18.6298	4.28	No	Yes	0	6	6
27	R:R:L133	R:R:W258	96.7936	4.56	No	Yes	0	5	7
28	R:R:S136	R:R:W258	69.6647	4.94	No	Yes	0	9	7
29	R:R:D90	R:R:S136	68.4877	5.89	Yes	No	0	9	9
30	R:R:D90	R:R:N62	74.4784	5.39	Yes	No	0	9	9
31	R:R:N62	R:R:P299	67.4974	8.15	No	No	0	9	9
32	R:R:P299	R:R:V65	65.7115	3.53	No	No	0	9	9
33	R:R:F313	R:R:V65	62.0911	6.55	Yes	No	0	6	9
34	R:R:A68	R:R:F313	48.9082	2.77	No	Yes	0	7	6
35	R:R:A68	R:R:T312	46.96	3.36	No	No	0	7	7
36	R:R:I316	R:R:T312	20.1559	3.04	No	No	0	7	7
37	R:R:I316	R:R:V67	17.9804	3.07	No	No	0	7	4
38	R:R:N72	R:R:T312	26.5849	5.85	No	No	0	7	7
39	R:R:L75	R:R:N72	20.1559	12.36	No	No	0	9	7
40	R:R:L75	R:R:Y80	13.4832	9.38	No	Yes	3	9	8
41	R:R:F254	R:R:W258	71.2152	9.02	Yes	Yes	4	8	7
42	R:R:F254	R:R:M208	95.3405	4.98	Yes	No	0	8	8
43	R:R:M208	R:R:Y212	93.9118	4.79	No	Yes	0	8	9
44	R:R:M215	R:R:Y212	87.0688	3.59	No	Yes	0	9	9
45	R:R:I151	R:R:M215	66.1011	4.37	No	No	0	8	9
46	R:R:I151	R:R:T150	52.3581	4.56	No	No	0	8	8
47	R:R:T150	R:R:Y157	50.0203	9.99	No	Yes	0	8	9
48	R:R:D146	R:R:Y157	30.733	5.75	No	Yes	0	9	9
49	R:R:D146	R:R:F82	25.7488	8.36	No	No	0	9	8
50	R:R:F82	R:R:I170	15.7237	5.02	No	No	0	8	7
51	R:R:I170	R:R:V166	13.1423	3.07	No	Yes	0	7	7
52	R:R:D90	R:R:L86	39.5081	6.79	Yes	Yes	0	9	9
53	R:R:L86	R:R:S139	30.6031	4.5	Yes	No	0	9	8
54	R:R:N294	R:R:W258	36.0744	11.3	No	Yes	0	9	7
55	R:R:D298	R:R:N294	26.9421	13.46	No	No	0	9	9
56	R:R:D298	R:R:L86	16.5598	6.79	No	Yes	2	9	9
57	R:R:S139	R:R:S85	27.2668	4.89	No	No	0	8	9
58	R:R:S85	R:R:W174	23.9143	4.94	No	Yes	0	9	9
59	R:R:E100	R:R:I125	17.2985	9.56	Yes	No	0	5	5
60	R:R:C130	R:R:G181	18.1102	3.92	No	No	0	4	6
61	R:R:C130	R:R:F184	13.4589	4.19	No	Yes	0	4	4
62	R:R:A135	R:R:W174	13.7592	7.78	No	Yes	0	7	9
63	R:R:A135	R:R:C177	10.3417	3.61	No	No	0	7	7
64	R:R:I137	R:R:W258	11.121	7.05	No	Yes	0	6	7
65	R:R:Y212	R:R:Y302	28.0542	3.97	Yes	Yes	2	9	9
66	R:R:L140	R:R:Y302	33.98	4.69	No	Yes	2	8	9
67	R:R:M215	R:R:Y148	21.0569	4.79	No	Yes	0	9	8
68	R:R:F152	R:R:Y148	15.3746	17.54	Yes	Yes	7	6	8
69	R:R:F152	R:R:I151	16.2676	7.54	Yes	No	0	6	8
70	R:R:M161	R:R:Y157	15.7237	8.38	No	Yes	0	7	9
71	R:R:F149	R:R:M161	13.1423	3.73	No	No	0	6	7
72	R:R:G181	R:R:S131	15.9023	1.86	No	No	0	6	4
73	R:R:S131	R:R:T178	13.6781	1.6	No	No	0	4	3
74	R:R:I182	R:R:T178	11.4376	3.04	No	No	0	3	3
75	R:R:F201	R:R:W258	13.8242	4.01	Yes	Yes	4	6	7
76	R:R:F201	R:R:F202	10.082	7.5	Yes	No	0	6	4
77	R:R:F261	R:R:F262	29.3611	5.36	Yes	No	0	5	5
78	R:R:F201	R:R:F262	29.8076	25.72	Yes	No	0	6	5
79	R:R:L205	R:R:V255	10.3905	4.47	No	No	0	6	5
80	R:R:L250	R:R:Y212	28.9634	5.86	Yes	Yes	2	8	9
81	R:R:L250	R:R:T246	32.3809	2.95	Yes	No	0	8	9
82	R:R:G243	R:R:T246	29.9862	3.64	No	No	0	8	9
83	R:R:F216	R:R:G243	27.5509	3.01	Yes	No	0	6	8
84	R:R:F216	R:R:L217	17.6881	2.44	Yes	No	0	6	4
85	R:R:L217	R:R:R220	12.7527	4.86	No	No	0	4	5
86	R:R:F152	R:R:M218	24.515	2.49	Yes	No	0	6	5
87	R:R:C257	R:R:N294	22.5911	6.3	No	No	0	8	9
88	R:R:I291	R:R:W258	61.3199	10.57	No	Yes	0	6	7
89	R:R:F280	R:R:Y287	25.7083	15.47	No	Yes	0	2	5
90	R:R:F267	R:R:F280	20.1072	11.79	No	No	0	4	2
91	R:R:C277	R:R:F267	11.5188	5.59	No	No	9	6	4
92	R:R:P48	R:R:T101	14.5223	1.75	Yes	Yes	0	5	6
93	R:R:C257	R:R:V253	19.823	1.71	No	No	0	8	6
94	R:R:I249	R:R:V253	14.2382	1.54	No	No	0	7	6
95	R:R:I245	R:R:I249	11.4214	2.94	No	No	0	7	7
96	L:L:H6	R:R:L288	42.3655	3.86	Yes	No	0	0	4
97	L:L:H6	R:R:T101	23.273	6.85	Yes	Yes	5	0	6
98	R:R:F261	R:R:I291	60.2078	5.02	Yes	No	0	5	6
99	R:R:F201	R:R:F254	28.6306	5.36	Yes	Yes	4	6	8
100	R:R:L140	R:R:L86	25.2131	5.54	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y2	R:R:V119	6.31	0	Yes	No	0	3	0	1
L:L:Y2	R:R:D122	11.49	0	Yes	No	0	8	0	1
L:L:M4	R:R:E100	4.06	0	No	Yes	0	5	0	1
L:L:M4	R:R:I104	7.29	0	No	No	0	4	0	1
L:L:M4	R:R:D122	12.48	0	No	No	0	8	0	1
L:L:H6	R:R:F51	12.44	5	Yes	Yes	0	6	0	1
L:L:H6	R:R:T101	6.85	5	Yes	Yes	0	6	0	1
L:L:H6	R:R:N285	7.65	5	Yes	No	0	4	0	1
L:L:H6	R:R:L288	3.86	5	Yes	No	0	4	0	1
L:L:F7	R:R:D126	4.78	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:I129	12.56	1	Yes	Yes	0	5	0	1
L:L:F7	R:R:C130	4.19	1	Yes	No	0	4	0	1
L:L:F7	R:R:L133	3.65	1	Yes	No	0	5	0	1
L:L:R8	R:R:N123	3.62	1	Yes	No	0	5	0	1
L:L:R8	R:R:D126	15.48	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:I185	7.52	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:S188	10.54	1	Yes	No	0	4	0	1
L:L:W9	R:R:S188	3.71	1	Yes	No	0	4	0	1
L:L:W9	R:R:I194	5.87	1	Yes	Yes	0	4	0	1
L:L:W9	R:R:L265	4.56	1	Yes	No	0	5	0	1
L:L:W9	R:R:Y268	11.58	1	Yes	No	0	5	0	1
L:L:G10	R:R:F284	10.54	0	No	Yes	0	3	0	1
L:L:K11	R:R:Q43	6.78	0	No	No	0	3	0	1
L:L:P12	R:R:M281	5.03	0	No	No	0	3	0	1
R:R:N285	R:R:V46	4.43	0	No	No	4	5	1	2
R:R:I289	R:R:V46	4.61	0	Yes	No	5	5	2	2
R:R:F51	R:R:T101	7.78	5	Yes	Yes	6	6	1	1
R:R:F51	R:R:I289	7.54	5	Yes	Yes	6	5	1	2
R:R:F51	R:R:M292	7.46	5	Yes	No	6	5	1	2
R:R:I129	R:R:S96	7.74	0	Yes	No	5	6	1	2
R:R:I129	R:R:N97	8.5	0	Yes	No	5	6	1	2
R:R:M292	R:R:N97	7.01	0	No	No	5	6	2	2
R:R:G98	R:R:T101	3.64	0	No	Yes	6	6	2	1
R:R:E100	R:R:I125	9.56	0	Yes	No	5	5	1	2
R:R:D126	R:R:E100	7.8	1	Yes	Yes	4	5	1	1
R:R:E100	R:R:I129	4.1	0	Yes	Yes	5	5	1	1
R:R:D122	R:R:D126	7.98	0	No	Yes	8	4	1	1
R:R:I185	R:R:N123	4.25	1	Yes	No	5	5	1	1
R:R:D126	R:R:I185	4.2	1	Yes	Yes	4	5	1	1
R:R:I185	R:R:S127	9.29	1	Yes	No	5	5	1	2
R:R:C130	R:R:G181	3.92	0	No	No	4	6	1	2
R:R:C130	R:R:F184	4.19	0	No	Yes	4	4	1	2
R:R:L133	R:R:W258	4.56	0	No	Yes	5	7	1	2
R:R:D189	R:R:S188	4.42	0	No	No	5	4	2	1
R:R:I194	R:R:L265	7.14	1	Yes	No	4	5	1	1
R:R:I194	R:R:Y268	3.63	1	Yes	No	4	5	1	1
R:R:I194	R:R:I269	5.89	1	Yes	No	4	4	1	2
R:R:F261	R:R:L265	3.65	0	Yes	No	5	5	2	1
R:R:F261	R:R:F284	6.43	0	Yes	Yes	5	3	2	1
R:R:H264	R:R:M281	6.57	0	No	No	4	3	2	1
R:R:F284	R:R:H264	10.18	0	Yes	No	3	4	1	2
R:R:P272	R:R:Q273	6.32	0	No	No	3	1	1	2
R:R:F284	R:R:L288	13.4	0	Yes	No	3	4	1	1
R:R:F284	R:R:Q43	3.51	0	Yes	No	3	3	1	1
R:R:T101	R:R:V52	3.17	5	Yes	No	6	4	1	2
R:R:N120	R:R:V119	2.96	0	No	No	1	3	2	1
L:L:Y2	R:R:T118	2.5	0	Yes	No	0	6	0	1
L:L:P12	R:R:P272	1.95	0	No	No	0	3	0	1
R:R:P48	R:R:T101	1.75	0	Yes	Yes	5	6	2	1
R:R:L107	R:R:T118	1.47	0	No	No	4	6	2	1
L:L:V13	R:R:Y268	1.26	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F53_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	254
Number of Links	281
Number of Hubs	35
Number of Links mediated by Hubs	134
Number of Communities	9
Number of Nodes involved in Communities	40
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	42665
Length Of Smallest Path	3
Average Path Length	12.5417
Length of Longest Path	26
Minimum Path Strength	1.395
Average Path Strength	6.06358
Maximum Path Strength	16.61
Minimum Path Correlation	0.7
Average Path Correlation	0.931159
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	53.6298
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.6572
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • melanocyte-stimulating hormone receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • response to bisphenol A • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • energy homeostasis • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • regulation of behavior • behavior • regulation of grooming behavior • regulation of multicellular organismal process • grooming behavior • feeding behavior • regulation of metabolic process • regulation of eating behavior • eating behavior • regulation of feeding behavior • response to peptide hormone • response to insulin • positive regulation of biological process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • tissue remodeling • bone remodeling • anatomical structure homeostasis • positive regulation of multicellular organismal process • positive regulation of bone resorption • response to melanocyte-stimulating hormone • negative regulation of feeding behavior • negative regulation of behavior • negative regulation of biological process • negative regulation of multicellular organismal process • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • peptide secretion • localization • secretion by cell • amide transport • signal release • cellular macromolecule localization • regulation of biological quality • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • response to food • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • molecular function activator activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide signaling pathway • circulatory system process • regulation of blood pressure • blood circulation • regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of localization • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • regulation of secretion by cell • regulation of signaling • regulation of transport • lipid localization • endocrine process • regulation of lipid localization • regulation of cell communication • carbohydrate metabolic process • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • calcium-mediated signaling • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • regulation of appetite • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32245
Sequence	>7F53_nogp_Chain_R G C Y E Q L F V S P E V F V T L G V I S L L E N I L V I V A I A K N K N L H S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L N S T S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y A L Q Y H N I M T V K R V G I I I S C I W A A C T V S G I L F I I Y S D S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L P G T Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C P Q N P Y C V C F M S H F N L Y L I L I M C N S I I D P L I Y A L R S Q E L R K T F K E I I C C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8QJ2	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-	Gs	3.4	2024-09-25	To be published
	8QJ2 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-		3.4	2024-09-25	To be published
	8WKZ	A	Peptide	Melanocortin	MC₄	Homo sapiens	SBL-MC-31	-	-	3.3	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8WKY	A	Peptide	Melanocortin	MC₄	Homo sapiens	PG-934	-	-	2.9	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	7PIV	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.86	2021-11-17	10.1038/s41422-021-00569-8
	7PIV (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.86	2021-11-17	10.1038/s41422-021-00569-8
	7PIU	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.58	2021-11-17	10.1038/s41422-021-00569-8
	7PIU (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.58	2021-11-17	10.1038/s41422-021-00569-8
	7F58	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-	Gs/β1/γ2	3.1	2021-11-03	10.1038/s41422-021-00552-3
	7F58 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-		3.1	2021-11-03	10.1038/s41422-021-00552-3
	7F55	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-	Gs/β1/γ2	3.1	2021-11-03	10.1038/s41422-021-00552-3
	7F55 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-		3.1	2021-11-03	10.1038/s41422-021-00552-3
	7F54	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-	Gs/β1/γ2	3	2021-11-03	10.1038/s41422-021-00552-3
	7F54 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-		3	2021-11-03	10.1038/s41422-021-00552-3
	7F53	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-	Gs/β1/γ2	3	2021-11-03	10.1038/s41422-021-00552-3
	7F53 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-		3	2021-11-03	10.1038/s41422-021-00552-3
	7AUE	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	chim(NtGi1L-Gs)/β1/γ2	2.97	2021-04-28	10.1126/science.abf7958
	7AUE (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.97	2021-04-28	10.1126/science.abf7958
	6W25	A	Peptide	Melanocortin	MC₄	Homo sapiens	SHU9119	Ca	-	2.75	2020-04-29	10.1126/science.aaz8995

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