Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Q43 5.42453
2R:R:S58 4.47418
3R:R:P78 4.42466
4R:R:Y80 7.04429748
5R:R:L86 4.178519
6R:R:N97 5.325406
7R:R:I125 5.34475
8R:R:I137 5.8825426
9R:R:Y148 9.65498
10R:R:F152 11.1675496
11R:R:Y157 6.352569
12R:R:M161 5.375467
13R:R:W174 4.61609
14R:R:I198 4.9225405
15R:R:F201 10.592526
16R:R:M204 3.98426
17R:R:Y212 4.605609
18R:R:F254 5.0575408
19R:R:W258 6.9627
20R:R:F261 7.412525
21R:R:F262 9.88625
22R:R:I266 3.8625435
23R:R:F267 10.1317634
24R:R:C271 4.9775435
25R:R:Y287 13.1925425
26R:R:I301 4.4675419
27R:R:Y302 6.216519
28R:R:L309 6.3675408
29R:R:T312 5.56407
30R:R:F313 6.752506
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D37 R:R:Y35 20.459418.39NoNo042
2R:R:F280 R:R:Y35 23.847520.63NoNo022
3R:R:F280 R:R:L263 13.43816.09NoNo325
4R:R:I266 R:R:L263 15.1022.85YesNo355
5R:R:I198 R:R:I266 50.33882.94YesYes055
6R:R:F262 R:R:I198 38.52965.02YesYes055
7R:R:F261 R:R:F262 34.492413.93YesYes255
8R:R:F261 R:R:Y287 14.87938.25YesYes255
9R:R:L290 R:R:Y287 10.988516.41NoYes075
10R:R:I289 R:R:L54 29.37362.85NoNo056
11R:R:I289 R:R:L286 14.12532.85NoNo052
12R:R:F267 R:R:F280 13.641733.22YesNo342
13R:R:F267 R:R:I266 26.90175.02YesYes345
14R:R:C279 R:R:D37 10.25673.11NoNo044
15R:R:F261 R:R:I291 33.6438.79YesNo256
16R:R:I291 R:R:L288 32.78722.85NoNo064
17R:R:L288 R:R:N97 22.84225.49NoYes046
18R:R:M292 R:R:N97 14.44665.61NoYes056
19R:R:F51 R:R:M292 13.11368.71NoNo065
20R:R:F51 R:R:T101 25.915411.67NoNo066
21R:R:T101 R:R:T105 24.55061.57NoNo064
22R:R:P48 R:R:T105 11.78066.99NoNo054
23R:R:I296 R:R:L54 26.50724.28NoNo066
24R:R:F262 R:R:W258 33.09583.01YesYes257
25R:R:N294 R:R:W258 37.909210.17NoYes097
26R:R:D298 R:R:N294 37.514712.12NoNo099
27R:R:D90 R:R:S295 14.00764.42NoNo199
28R:R:S295 R:R:S58 10.53356.52NoYes198
29R:R:F202 R:R:I198 16.95998.79NoYes045
30R:R:F201 R:R:F202 17.47215.36YesNo064
31R:R:F201 R:R:F254 49.29214.29YesYes068
32R:R:F254 R:R:L140 41.20193.65YesNo088
33R:R:L140 R:R:L86 50.86375.54NoYes089
34R:R:L86 R:R:S139 1003YesNo098
35R:R:S139 R:R:S85 99.16654.89NoNo089
36R:R:I170 R:R:S85 93.29373.1NoNo079
37R:R:F82 R:R:I170 92.32346.28NoNo087
38R:R:D146 R:R:F82 87.37635.97NoNo098
39R:R:D146 R:R:M79 70.91914.16NoNo098
40R:R:M79 R:R:Y80 69.84385.99NoYes088
41R:R:I69 R:R:Y80 26.00454.84NoYes088
42R:R:I69 R:R:L309 24.76068.56NoYes088
43R:R:F313 R:R:L309 26.456310.96YesYes068
44R:R:F201 R:R:F262 36.512630.01YesYes265
45R:R:D298 R:R:L86 31.24424.07NoYes199
46R:R:S306 R:R:Y80 26.00137.63NoYes478
47R:R:L309 R:R:S306 24.85293YesNo087
48R:R:I316 R:R:V67 15.95461.54NoNo074
49R:R:E315 R:R:I316 19.92816.83NoNo037
50R:R:E315 R:R:T312 23.89534.23NoYes037
51R:R:N72 R:R:T312 10.676711.7NoYes077
52R:R:L75 R:R:N72 13.126.87NoNo097
53R:R:L75 R:R:Y80 14.357517.58NoYes498
54R:R:L309 R:R:T312 21.17522.95YesYes087
55R:R:D146 R:R:Y157 16.60686.9NoYes099
56R:R:S85 R:R:W174 15.31517.41NoYes099
57R:R:I143 R:R:L86 22.00552.85NoYes199
58R:R:L140 R:R:Y302 20.6635.86NoYes089
59R:R:I143 R:R:Y302 15.64283.63NoYes199
60R:R:I104 R:R:T105 11.78061.52NoNo044
61R:R:E100 R:R:I104 10.32994.1NoNo054
62R:R:F201 R:R:I137 21.22296.28YesYes266
63R:R:I137 R:R:M200 14.70435.83YesNo264
64R:R:L134 R:R:M200 14.39897.07NoNo054
65R:R:L134 R:R:S180 13.53357.51NoNo054
66R:R:G181 R:R:S180 12.66823.71NoNo064
67R:R:I137 R:R:W258 20.92397.05YesYes267
68R:R:L133 R:R:W258 14.35757.97NoYes057
69R:R:F261 R:R:L133 14.01393.65YesNo055
70R:R:I137 R:R:M204 25.89324.37YesYes266
71R:R:L141 R:R:M204 22.00245.65NoYes076
72R:R:L141 R:R:V145 18.66832.98NoNo077
73R:R:F149 R:R:V145 16.99172.62NoNo067
74R:R:F149 R:R:Y148 13.61942.06NoYes068
75R:R:F284 R:R:L288 10.12959.74NoNo034
76R:R:L247 R:R:Y212 12.31513.52NoYes089
77R:R:I301 R:R:Y302 32.99086.04YesYes199
78R:R:I301 R:R:V253 29.22724.61YesNo096
79R:R:I297 R:R:V253 28.24426.14NoNo076
80R:R:I296 R:R:I297 27.4332.94NoNo067
81R:R:F313 R:R:L304 10.80088.53YesNo066
82R:R:F51 R:R:I289 16.22826.28NoNo065
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K3K_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.85
Number of Linked Nodes 253
Number of Links 280
Number of Hubs 30
Number of Links mediated by Hubs 119
Number of Communities 9
Number of Nodes involved in Communities 48
Number of Links involved in Communities 61
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 62075
Length Of Smallest Path 3
Average Path Length 15.5484
Length of Longest Path 32
Minimum Path Strength 1.14
Average Path Strength 6.12302
Maximum Path Strength 26.925
Minimum Path Correlation 0.7
Average Path Correlation 0.942911
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 49.3551
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 34.486
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body   • neuropeptide binding   • peptide binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • melanocortin receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • melanocyte-stimulating hormone receptor activity   • regulation of behavior   • behavior   • regulation of eating behavior   • eating behavior   • feeding behavior   • regulation of feeding behavior   • response to insulin   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • positive regulation of bone resorption   • response to melanocyte-stimulating hormone   • response to nutrient levels   • response to food
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP32245
Sequence
>9K3K_nogp_Chain_R
YSDGGCYEQ LFVSPEVFV TLGVISLLE NILVIVAIA KNKNLHSPM 
YFFICSLAV ADMLVSVSN GSETIVITL LSFTVNIDN VIDSVICSS 
LLASICSLL SIAVDRYFT IFYALQYHN IMTVKRVGI IISCIWAAC 
TVSGILFII YSDSSAVII CLITMFFTM LALMASLYV HMFLMARLH 
IKRIAVLPG TQGANMKGA ITLTILIGV FVVCWAPFF LHLIFYISC 
PQNPYCVCF MSHFNLYLI LIMCNSIID PLIYALRSQ ELRKTFKEI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W25APeptideMelanocortinMC4Homo sapiensSHU9119Ca-2.752020-04-29doi.org/10.1126/science.aaz8995
7F53APeptideMelanocortinMC4Homo sapiensα-MSH-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F53 (No Gprot) APeptideMelanocortinMC4Homo sapiensα-MSH-32021-11-03doi.org/10.1038/s41422-021-00552-3
7F54APeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F54 (No Gprot) APeptideMelanocortinMC4Homo sapiensAfamelanotide-32021-11-03doi.org/10.1038/s41422-021-00552-3
7F55APeptideMelanocortinMC4Homo sapiensBremelanotide-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F55 (No Gprot) APeptideMelanocortinMC4Homo sapiensBremelanotide-3.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58APeptideMelanocortinMC4Homo sapiensTHIQ-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58 (No Gprot) APeptideMelanocortinMC4Homo sapiensTHIQ-3.12021-11-03doi.org/10.1038/s41422-021-00552-3
7PIUAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/β1/γ22.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIU (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIVAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/β1/γ22.862021-11-17doi.org/10.1038/s41422-021-00569-8
7PIV (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.862021-11-17doi.org/10.1038/s41422-021-00569-8
7AUEAPeptideMelanocortinMC4Homo sapiensSetmelanotide-chim(NtGi1L-Gs)/β1/γ22.972021-04-28doi.org/10.1126/science.abf7958
7AUE (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.972021-04-28doi.org/10.1126/science.abf7958
8WKYAPeptideMelanocortinMC4Homo sapiensPG-934--2.92024-08-07doi.org/10.1021/acs.jmedchem.3c01822
8WKZAPeptideMelanocortinMC4Homo sapiensSBL-MC-31--3.32024-08-07doi.org/10.1021/acs.jmedchem.3c01822
8QJ2APeptideMelanocortinMC4Homo sapienspN162-Gs3.42024-09-25doi.org/10.1038/s41467-024-50827-7
8QJ2 (No Gprot) APeptideMelanocortinMC4Homo sapienspN162-3.42024-09-25doi.org/10.1038/s41467-024-50827-7
9K3KAPeptideMelanocortinMC4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.122025-08-06doi.org/10.1016/j.str.2025.03.004
9K3K (No Gprot) APeptideMelanocortinMC4Homo sapiens--3.122025-08-06doi.org/10.1016/j.str.2025.03.004




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