Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K34 4.29404
2A:A:H41 5.025406
3A:A:N50 6.1965156
4A:A:S51 4.215409
5A:A:V214 5.4075426
6A:A:F219 6.716508
7A:A:E230 6.02419
8A:A:K233 6.78519
9A:A:W234 6.574519
10A:A:F238 9.2925419
11A:A:D249 6.5954158
12A:A:D252 5.444158
13A:A:Y253 6.406508
14A:A:R265 10.98754159
15A:A:F273 5.002867109
16A:A:W277 9.51754106
17A:A:W281 8.58333615
18A:A:L289 4.9825109
19A:A:F290 6.574239
20A:A:Q294 6.21476
21A:A:L297 4.125478
22A:A:F312 4.405408
23A:A:F315 11.665406
24A:A:Y318 7.5825406
25A:A:P321 4.405405
26A:A:V334 3.3175404
27A:A:Y339 7.8725473
28A:A:F340 10.3375407
29A:A:R342 7.41474
30A:A:F345 8.44754108
31A:A:L346 6.3725474
32A:A:Y358 5.83424
33A:A:Y360 6.12833628
34A:A:F363 6.778575
35A:A:T364 5.95754239
36A:A:N371 8.424239
37A:A:F376 4.57167628
38A:A:R385 9.18425
39A:A:Y391 9.232564
40B:B:L7 3.6175408
41B:B:L14 2.8408
42B:B:D27 8.53408
43B:B:L30 3.2375405
44B:B:V40 3.88403
45B:B:H54 9.3945269
46B:B:K57 9.8975419
47B:B:Y59 7.568518
48B:B:W63 7.856507
49B:B:Q75 7.7325419
50B:B:D76 7.2545269
51B:B:K78 5.0775408
52B:B:W82 13.3625409
53B:B:Y85 11.8054144
54B:B:N88 6.6625407
55B:B:K89 8.3165219
56B:B:H91 4.944205
57B:B:I93 5.13407
58B:B:L95 6.594118
59B:B:W99 9.968519
60B:B:M101 5.2175419
61B:B:Y105 4.612506
62B:B:Y111 5.5375404
63B:B:C121 4.135488
64B:B:I123 4.0225406
65B:B:Y124 5.206676116
66B:B:E138 4.62754116
67B:B:Y145 6.265818
68B:B:C148 4.2875446
69B:B:F151 5.54333609
70B:B:T159 6.695489
71B:B:S160 4.045446
72B:B:W169 9.40571788
73B:B:F180 7.294547
74B:B:H183 9.1549
75B:B:D186 5.708519
76B:B:V187 4.5725449
77B:B:L190 4.6475445
78B:B:F199 6.826549
79B:B:V200 6.27436
80B:B:S201 4.6075449
81B:B:C204 5.5225417
82B:B:D205 7449
83B:B:K209 11.7725446
84B:B:L210 5.42405
85B:B:W211 7.17429748
86B:B:F222 8.0425438
87B:B:H225 7.82333639
88B:B:D228 9.1975419
89B:B:I232 5.8625438
90B:B:F234 6.7325405
91B:B:F235 7.186676186
92B:B:F241 6.464536
93B:B:T243 5.5575438
94B:B:D247 7.51439
95B:B:T249 5.04436
96B:B:R251 10.7725438
97B:B:F253 8.4475436
98B:B:R256 8.1925409
99B:B:D258 9.2225437
100B:B:Q259 4.905406
101B:B:M262 4.9675404
102B:B:Y264 6.19505
103B:B:I273 6.3554166
104B:B:F278 7.51407
105B:B:R283 7.55409
106B:B:Y289 6.385717167
107B:B:D290 6.882516
108B:B:H311 9.66559
109B:B:R314 13.558518
110B:B:V315 4.834557
111B:B:T329 5.19558
112B:B:W332 9.85143719
113B:B:D333 7.8725459
114B:B:K337 7.8225456
115B:B:W339 7.075659
116G:G:A23 2.735408
117G:G:Y40 8.49254186
118G:G:D48 6.384509
119G:G:L51 4.066506
120G:G:P60 9.48754149
121G:G:F61 5.49758148
122R:R:Q43 5.424273
123R:R:S58 4.474138
124R:R:P78 4.42466
125R:R:Y80 7.044297198
126R:R:L86 4.514139
127R:R:N97 5.325406
128R:R:I125 5.344285
129R:R:I137 5.8825496
130R:R:R147 10.0525469
131R:R:F152 11.1675426
132R:R:L155 3.6475408
133R:R:Y157 7.395469
134R:R:M161 5.375467
135R:R:W174 4.61609
136R:R:I198 4.9225405
137R:R:F201 10.592596
138R:R:Y212 4.605609
139R:R:H222 7.1875427
140R:R:F254 5.0575408
141R:R:W258 6.9697
142R:R:F261 7.412595
143R:R:F262 9.88695
144R:R:F267 10.13176124
145R:R:C271 4.97754125
146R:R:Y287 13.1925495
147R:R:I301 4.4675469
148R:R:Y302 6.216569
149R:R:F313 6.752506
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:S72 10.20185.58YesNo099
2B:B:D76 B:B:H54 13.85566.3YesYes2699
3B:B:D66 B:B:R68 74.53383.57NoNo085
4B:B:D66 B:B:L69 74.42975.43NoNo085
5B:B:L69 B:B:Y105 74.32795.86NoYes056
6B:B:V112 B:B:Y105 12.00363.79NoYes086
7B:B:V112 B:B:Y124 11.73313.79NoYes086
8A:A:F376 A:A:R380 11.89673.21YesNo287
9A:A:Q384 A:A:R380 12.54785.84NoNo267
10A:A:Q384 R:R:M218 11.9875.44NoNo265
11R:R:F152 R:R:M218 39.00238.71YesNo265
12R:R:F152 R:R:I151 40.09476.28YesNo068
13A:A:Y391 R:R:I151 41.98643.63YesNo048
14A:A:Y391 R:R:T150 91.71027.49YesNo648
15R:R:T150 R:R:Y157 92.03638.74NoYes689
16R:R:P78 R:R:Y157 95.67275.56YesYes669
17R:R:P78 R:R:V166 99.73083.53YesNo067
18R:R:F81 R:R:V166 99.84093.93NoNo047
19R:R:F81 R:R:H76 99.89517.92NoNo048
20R:R:H76 R:R:K73 99.948910.48NoNo085
21B:B:R52 R:R:K73 10011.14NoNo075
22B:B:R52 B:B:T50 97.53285.17NoNo073
23B:B:K337 B:B:T50 97.579210.51YesNo063
24B:B:K337 B:B:W339 96.76285.8YesYes569
25B:B:M45 B:B:W339 98.99483.49NoYes549
26B:B:M45 G:G:L50 99.20257.07NoNo049
27B:B:S279 G:G:L50 99.23293NoNo099
28B:B:S279 G:G:D48 99.26278.83NoYes099
29G:G:D48 G:G:P49 97.18933.22YesNo097
30B:B:M325 G:G:P49 97.1345.03NoNo057
31B:B:M325 G:G:P60 96.907610.06NoYes059
32B:B:Y85 G:G:P60 75.066512.52YesYes1449
33B:B:R68 B:B:Y85 75.334925.72NoYes054
34R:R:H222 R:R:M218 26.74065.25YesNo275
35A:A:D381 R:R:H222 13.34633.78NoYes087
36A:A:D381 A:A:Y360 12.73313.45NoYes088
37A:A:D378 A:A:Y360 23.60939.2NoYes078
38A:A:D378 A:A:I288 20.429211.2NoNo079
39A:A:F290 A:A:I288 19.16765.02YesNo099
40A:A:R385 R:R:H222 13.981813.54YesYes257
41A:A:R385 A:A:Y360 12.731610.29YesYes258
42B:B:H62 B:B:Y105 72.2973.27NoYes066
43B:B:H62 B:B:R150 72.16239.03NoNo066
44B:B:C148 B:B:R150 72.02815.57YesNo066
45B:B:C148 B:B:S160 45.8223.44YesYes466
46B:B:S147 B:B:S160 45.27164.89NoYes096
47B:B:S147 B:B:Y145 45.0513.82NoYes098
48A:A:W234 B:B:Y145 30.1123.86YesYes198
49A:A:F238 A:A:W234 28.86346.01YesYes199
50A:A:F238 A:A:L44 28.605319.49YesNo099
51A:A:I244 A:A:L44 28.0844.28NoNo089
52A:A:F290 A:A:T364 15.35777.78YesYes2399
53A:A:N292 A:A:T364 11.56495.85NoYes099
54A:A:N292 A:A:V247 10.92684.43NoNo097
55A:A:S51 A:A:V247 10.28824.85YesNo097
56A:A:I244 A:A:V287 27.03533.07NoNo086
57A:A:F273 A:A:V287 14.9685.24YesNo1096
58A:A:F273 A:A:L289 12.49073.65YesYes1099
59A:A:L289 A:A:L291 12.32375.54YesNo098
60A:A:F363 A:A:L291 12.05193.65YesNo058
61B:B:C148 B:B:T102 33.5593.38YesNo068
62B:B:C149 B:B:T102 33.31785.07NoNo088
63B:B:C121 B:B:C149 21.32173.64YesNo888
64B:B:C121 B:B:T159 11.4923.38YesYes889
65B:B:C149 B:B:L146 11.75423.17NoNo887
66B:B:L146 B:B:T159 11.49174.42NoYes879
67A:A:V287 A:A:W277 11.80354.9NoYes1066
68A:A:S349 A:A:W277 10.22414.94NoYes076
69A:A:L346 A:A:S349 10.00293YesNo047
70A:A:Y391 R:R:R147 72.923520.58YesYes649
71R:R:R147 R:R:Y212 30.31047.2YesYes099
72G:G:D48 G:G:L51 44.4626.79YesYes096
73B:B:R283 G:G:L51 41.66764.86YesYes096
74B:B:I37 B:B:R283 39.22823.76NoYes029
75B:B:I37 G:G:M38 38.72567.29NoNo024
76B:B:T34 G:G:M38 38.47353.01NoNo054
77B:B:L30 B:B:T34 38.22092.95YesNo055
78B:B:L261 B:B:L30 22.9652.77NoYes055
79B:B:L261 G:G:V30 22.68232.98NoNo058
80B:B:Q259 G:G:V30 21.2614.3YesNo068
81B:B:Q259 B:B:R22 20.4024.67YesNo066
82B:B:D258 B:B:R22 14.2589.53YesNo076
83B:B:L30 B:B:M262 16.62565.65YesYes054
84B:B:L51 B:B:W82 11.923421.64NoYes099
85B:B:I338 B:B:L51 17.55994.28NoNo059
86B:B:I157 B:B:W169 24.72663.52NoYes078
87B:B:F151 B:B:I157 23.909910.05YesNo097
88B:B:T159 B:B:W169 18.614912.13YesYes898
89B:B:F151 B:B:I123 18.17855.02YesYes096
90B:B:D258 B:B:F222 11.80794.78YesYes378
91B:B:M262 B:B:Y264 14.8534.79YesYes045
92R:R:M208 R:R:Y212 26.56054.79NoYes089
93R:R:F254 R:R:M208 26.33824.98YesNo088
94R:R:F201 R:R:F254 50.7294.29YesYes068
95R:R:F201 R:R:F202 13.78165.36YesNo064
96R:R:F202 R:R:I198 13.258.79NoYes045
97R:R:I198 R:R:I266 24.24952.94YesNo055
98R:R:F267 R:R:I266 18.74265.02YesNo1245
99R:R:R147 R:R:Y302 42.45816.17YesYes699
100R:R:L140 R:R:Y302 31.55055.86NoYes089
101R:R:F254 R:R:L140 27.61313.65YesNo088
102R:R:F201 R:R:F262 29.375630.01YesYes965
103R:R:F262 R:R:I198 14.32085.02YesYes055
104R:R:I301 R:R:Y302 11.94266.04YesYes699
105R:R:I301 R:R:V253 10.45954.61YesNo096
106R:R:I297 R:R:V253 10.18316.14NoNo076
107R:R:D146 R:R:Y157 14.18386.9NoYes099
108R:R:D146 R:R:F82 12.03925.97NoNo098
109R:R:F82 R:R:I170 11.11766.28NoNo087
110R:R:I170 R:R:S85 10.95723.1NoNo079
111R:R:P78 R:R:S77 11.52443.56YesNo067
112R:R:S77 R:R:Y80 11.236.36NoYes078
113R:R:F261 R:R:F262 11.550413.93YesYes955
114G:G:F61 G:G:P60 20.74027.22YesYes1489
115B:B:I338 G:G:F61 17.81695.02NoYes058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K3K
Class A
SubFamily Peptide
Type Melanocortin
SubType MC4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.12
Date 2025-08-06
D.O.I. doi.org/10.1016/j.str.2025.03.004
Net Summary
Imin 3
Number of Linked Nodes 846
Number of Links 992
Number of Hubs 149
Number of Links mediated by Hubs 549
Number of Communities 29
Number of Nodes involved in Communities 210
Number of Links involved in Communities 290
Path Summary
Number Of Nodes in MetaPath 116
Number Of Links MetaPath 115
Number of Shortest Paths 737706
Length Of Smallest Path 3
Average Path Length 29.8947
Length of Longest Path 66
Minimum Path Strength 1.315
Average Path Strength 6.81211
Maximum Path Strength 26.925
Minimum Path Correlation 0.7
Average Path Correlation 0.975263
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 47.9285
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.2183
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • neuropeptide binding   • peptide binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • melanocortin receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • melanocyte-stimulating hormone receptor activity   • metabolic process   • regulation of metabolic process   • regulation of behavior   • behavior   • regulation of eating behavior   • eating behavior   • feeding behavior   • regulation of feeding behavior   • regulation of multicellular organismal process   • response to peptide hormone   • response to insulin   • homeostatic process   • positive regulation of biological process   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • positive regulation of multicellular organismal process   • positive regulation of bone resorption   • response to melanocyte-stimulating hormone   • establishment of protein localization   • nitrogen compound transport   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • localization   • secretion by cell   • amide transport   • signal release   • regulation of biological quality   • intracellular protein localization   • secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • export from cell   • protein secretion   • establishment of localization   • peptide transport   • protein transport   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • response to nutrient levels   • response to food
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9K3K_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHTSGI 
FETKFQVDK VNFHMFDVG QRDERRKWI QCFNDVTAI IFVVSSYNR 
LQEALNFKS IWNNRWLRT ISVILFLNK QDLLAEKVL AGKSKIEDY 
FPEFARYTT PEDATPEPG EDPRVTRAK YFIRDEFLR ISTASGDGR 
HYCYPHFTC VDTENRRFN DCRDIIQRM HLRQYELLL SADAVRSMD 
NYADDDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K3K_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9K3K_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP32245
Sequence
>9K3K_Chain_R
YSDGGCYEQ LFVSPEVFV TLGVISLLE NILVIVAIA KNKNLHSPM 
YFFICSLAV ADMLVSVSN GSETIVITL LSFTVNIDN VIDSVICSS 
LLASICSLL SIAVDRYFT IFYALQYHN IMTVKRVGI IISCIWAAC 
TVSGILFII YSDSSAVII CLITMFFTM LALMASLYV HMFLMARLH 
IKRIAVLPG TQGANMKGA ITLTILIGV FVVCWAPFF LHLIFYISC 
PQNPYCVCF MSHFNLYLI LIMCNSIID PLIYALRSQ ELRKTFKEI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W25APeptideMelanocortinMC4Homo sapiensSHU9119Ca-2.752020-04-29doi.org/10.1126/science.aaz8995
7F53APeptideMelanocortinMC4Homo sapiensα-MSH-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F53 (No Gprot) APeptideMelanocortinMC4Homo sapiensα-MSH-32021-11-03doi.org/10.1038/s41422-021-00552-3
7F54APeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F54 (No Gprot) APeptideMelanocortinMC4Homo sapiensAfamelanotide-32021-11-03doi.org/10.1038/s41422-021-00552-3
7F55APeptideMelanocortinMC4Homo sapiensBremelanotide-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F55 (No Gprot) APeptideMelanocortinMC4Homo sapiensBremelanotide-3.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58APeptideMelanocortinMC4Homo sapiensTHIQ-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58 (No Gprot) APeptideMelanocortinMC4Homo sapiensTHIQ-3.12021-11-03doi.org/10.1038/s41422-021-00552-3
7PIUAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/β1/γ22.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIU (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIVAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/β1/γ22.862021-11-17doi.org/10.1038/s41422-021-00569-8
7PIV (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.862021-11-17doi.org/10.1038/s41422-021-00569-8
7AUEAPeptideMelanocortinMC4Homo sapiensSetmelanotide-chim(NtGi1L-Gs)/β1/γ22.972021-04-28doi.org/10.1126/science.abf7958
7AUE (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.972021-04-28doi.org/10.1126/science.abf7958
8WKYAPeptideMelanocortinMC4Homo sapiensPG-934--2.92024-08-07doi.org/10.1021/acs.jmedchem.3c01822
8WKZAPeptideMelanocortinMC4Homo sapiensSBL-MC-31--3.32024-08-07doi.org/10.1021/acs.jmedchem.3c01822
8QJ2APeptideMelanocortinMC4Homo sapienspN162-Gs3.42024-09-25doi.org/10.1038/s41467-024-50827-7
8QJ2 (No Gprot) APeptideMelanocortinMC4Homo sapienspN162-3.42024-09-25doi.org/10.1038/s41467-024-50827-7
9K3K (No Gprot) APeptideMelanocortinMC4Homo sapiens--3.122025-08-06doi.org/10.1016/j.str.2025.03.004




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