psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C279	R:R:C40	7.28	No	No	0	4	2
2	R:R:E42	R:R:Y41	6.73	No	No	0	3	6
3	R:R:H283	R:R:L44	6.43	No	No	0	4	2
4	R:R:F51	R:R:V46	3.93	Yes	No	4	6	5
5	R:R:N285	R:R:V46	5.91	No	No	0	4	5
6	R:R:I289	R:R:V46	4.61	Yes	No	4	5	5
7	R:R:F51	R:R:T101	7.78	Yes	Yes	0	6	6
8	R:R:F51	R:R:I289	6.28	Yes	Yes	4	6	5
9	R:R:F51	R:R:M292	7.46	Yes	No	0	6	5
10	L:L:H3	R:R:F51	4.53	No	Yes	0	0	6
11	R:R:I102	R:R:V52	4.61	No	No	0	6	4
12	R:R:I289	R:R:L54	4.28	Yes	Yes	0	5	6
13	R:R:L54	R:R:M292	5.65	Yes	No	0	6	5
14	R:R:I296	R:R:L54	4.28	No	Yes	0	6	6
15	R:R:G55	R:R:S94	3.71	No	No	0	6	8
16	R:R:E61	R:R:I57	4.1	No	No	0	8	5
17	R:R:S58	R:R:S94	6.52	No	No	0	8	8
18	R:R:I296	R:R:S58	6.19	No	No	0	6	8
19	R:R:I63	R:R:L59	5.71	No	No	0	4	6
20	R:R:E61	R:R:I296	5.47	No	No	0	8	6
21	R:R:A87	R:R:N62	4.69	No	No	0	9	9
22	R:R:D90	R:R:N62	6.73	Yes	No	0	9	9
23	R:R:N62	R:R:P299	4.89	No	No	0	9	9
24	R:R:F313	R:R:L64	3.65	Yes	No	0	6	7
25	R:R:F313	R:R:V65	6.55	Yes	No	0	6	9
26	R:R:C84	R:R:I66	4.91	No	No	0	5	7
27	R:R:K71	R:R:V67	4.55	No	No	0	5	4
28	R:R:I69	R:R:Y80	3.63	No	Yes	2	8	8
29	R:R:I69	R:R:L309	4.28	No	No	2	8	8
30	R:R:N72	R:R:N74	5.45	No	No	0	7	6
31	R:R:L75	R:R:N72	13.73	Yes	No	0	9	7
32	R:R:N72	R:R:T312	8.77	No	No	0	7	7
33	R:R:L75	R:R:Y80	10.55	Yes	Yes	2	9	8
34	R:R:E308	R:R:L75	6.63	No	Yes	2	6	9
35	R:R:L309	R:R:L75	4.15	No	Yes	2	8	9
36	R:R:F81	R:R:H76	6.79	No	No	0	4	8
37	R:R:S77	R:R:Y80	6.36	No	Yes	0	7	8
38	R:R:P78	R:R:Y157	4.17	No	Yes	0	6	9
39	R:R:P78	R:R:V166	3.53	No	No	0	6	7
40	R:R:D146	R:R:M79	9.7	No	No	0	9	8
41	R:R:S306	R:R:Y80	7.63	No	Yes	2	7	8
42	R:R:E308	R:R:Y80	4.49	No	Yes	2	6	8
43	R:R:L309	R:R:Y80	3.52	No	Yes	2	8	8
44	R:R:F81	R:R:V166	3.93	No	No	0	4	7
45	R:R:F82	R:R:S142	6.61	No	No	0	8	7
46	R:R:D146	R:R:F82	8.36	No	No	0	9	8
47	R:R:F82	R:R:I170	5.02	No	No	0	8	7
48	R:R:S139	R:R:S85	4.89	No	No	0	8	9
49	R:R:S85	R:R:W174	4.94	No	Yes	0	9	9
50	R:R:D90	R:R:L86	5.43	Yes	Yes	0	9	9
51	R:R:L86	R:R:S139	4.5	Yes	No	0	9	8
52	R:R:L140	R:R:L86	5.54	No	Yes	3	8	9
53	R:R:D298	R:R:L86	4.07	Yes	Yes	3	9	9
54	R:R:V88	R:R:W174	3.68	No	Yes	0	6	9
55	R:R:D90	R:R:S136	4.42	Yes	No	0	9	9
56	R:R:D90	R:R:S295	8.83	Yes	No	0	9	9
57	R:R:L92	R:R:S132	6.01	No	No	0	6	6
58	R:R:S132	R:R:V93	4.85	No	No	0	6	8
59	R:R:L133	R:R:V93	5.96	No	No	0	5	8
60	R:R:S295	R:R:V93	4.85	No	No	0	9	8
61	R:R:S96	R:R:V128	4.85	No	No	0	6	4
62	R:R:I129	R:R:S96	4.64	No	No	0	5	6
63	R:R:I129	R:R:N97	9.91	No	No	0	5	6
64	R:R:M292	R:R:N97	8.41	No	No	0	5	6
65	R:R:D122	R:R:E100	3.9	No	Yes	1	8	5
66	R:R:E100	R:R:I125	9.56	Yes	No	0	5	5
67	R:R:D126	R:R:E100	7.8	Yes	Yes	1	4	5
68	L:L:?1	R:R:E100	7.46	Yes	Yes	1	0	5
69	L:L:?4	R:R:E100	5.61	Yes	Yes	1	0	5
70	L:L:?1	R:R:I104	9.37	Yes	No	0	0	4
71	R:R:F117	R:R:S116	3.96	No	No	0	5	3
72	R:R:D122	R:R:D126	7.98	No	Yes	1	8	4
73	L:L:?1	R:R:D122	22.91	Yes	No	1	0	8
74	R:R:D126	R:R:I185	4.2	Yes	Yes	1	4	5
75	L:L:?4	R:R:D126	14.95	Yes	Yes	1	0	4
76	L:L:R5	R:R:D126	8.34	Yes	Yes	1	0	4
77	R:R:I185	R:R:S127	9.29	Yes	No	0	5	5
78	L:L:?4	R:R:I129	12.09	Yes	No	0	0	5
79	R:R:C130	R:R:G181	3.92	No	No	0	4	6
80	R:R:C130	R:R:F184	4.19	No	Yes	0	4	4
81	R:R:A135	R:R:W174	7.78	No	Yes	0	7	9
82	R:R:A135	R:R:C177	3.61	No	No	0	7	7
83	R:R:S136	R:R:W258	4.94	No	Yes	0	9	7
84	R:R:I137	R:R:M204	5.83	No	No	0	6	6
85	R:R:I137	R:R:W258	3.52	No	Yes	0	6	7
86	R:R:C138	R:R:C177	3.64	No	No	0	5	7
87	R:R:D298	R:R:L140	5.43	Yes	No	3	9	8
88	R:R:L140	R:R:Y302	4.69	No	Yes	3	8	9
89	R:R:L141	R:R:M204	4.24	No	No	0	7	6
90	R:R:L141	R:R:L207	4.15	No	No	0	7	5
91	R:R:I143	R:R:Y302	6.04	No	Yes	0	9	9
92	R:R:A144	R:R:Y212	5.34	No	Yes	0	9	9
93	R:R:D146	R:R:Y157	5.75	No	Yes	0	9	9
94	R:R:R147	R:R:Y302	6.17	No	Yes	0	9	9
95	R:R:F152	R:R:Y148	20.63	Yes	Yes	5	6	8
96	R:R:L211	R:R:Y148	14.07	No	Yes	0	7	8
97	R:R:H214	R:R:Y148	13.07	No	Yes	5	4	8
98	R:R:M215	R:R:Y148	4.79	No	Yes	0	9	8
99	R:R:F149	R:R:Y153	6.19	No	No	0	6	6
100	R:R:F149	R:R:M161	6.22	No	No	0	6	7
101	R:R:I151	R:R:T150	4.56	No	No	0	8	8
102	R:R:T150	R:R:Y157	9.99	No	Yes	0	8	9
103	R:R:F152	R:R:I151	6.28	Yes	No	0	6	8
104	R:R:I151	R:R:M215	4.37	No	No	0	8	9
105	R:R:F152	R:R:H214	14.71	Yes	No	5	6	4
106	R:R:H158	R:R:Y157	6.53	No	Yes	0	6	9
107	R:R:M161	R:R:Y157	9.58	No	Yes	0	7	9
108	R:R:R165	R:R:T162	6.47	No	No	0	6	8
109	R:R:F184	R:R:S180	3.96	Yes	No	0	4	4
110	R:R:F184	R:R:V193	7.87	Yes	No	0	4	5
111	R:R:F184	R:R:L197	4.87	Yes	No	0	4	5
112	L:L:R5	R:R:I185	3.76	Yes	Yes	1	0	5
113	R:R:I186	R:R:Y187	7.25	No	No	0	4	4
114	R:R:D189	R:R:S188	4.42	No	No	0	5	4
115	L:L:R5	R:R:S188	10.54	Yes	No	1	0	4
116	L:L:W6	R:R:S188	6.18	Yes	No	1	0	4
117	R:R:I194	R:R:L265	7.14	No	No	0	4	5
118	R:R:I194	R:R:I269	5.89	No	No	0	4	4
119	L:L:W6	R:R:I194	8.22	Yes	No	0	0	4
120	R:R:I198	R:R:I266	4.42	No	No	0	5	5
121	R:R:F201	R:R:F202	7.5	Yes	No	0	6	4
122	R:R:F201	R:R:W258	4.01	Yes	Yes	0	6	7
123	R:R:F201	R:R:F262	31.08	Yes	No	0	6	5
124	R:R:F202	R:R:I266	3.77	No	No	0	4	5
125	R:R:F254	R:R:L205	4.87	No	No	0	8	6
126	R:R:L205	R:R:V255	4.47	No	No	0	6	5
127	R:R:M208	R:R:Y212	5.99	No	Yes	0	8	9
128	R:R:F254	R:R:M208	4.98	No	No	0	8	8
129	R:R:M215	R:R:Y212	3.59	No	Yes	0	9	9
130	R:R:L250	R:R:Y212	5.86	Yes	Yes	0	8	9
131	R:R:F216	R:R:L247	12.18	No	No	0	6	8
132	R:R:L217	R:R:R220	3.64	No	No	0	4	5
133	R:R:L221	R:R:M218	5.65	No	No	0	5	5
134	R:R:H222	R:R:M218	6.57	No	No	0	7	5
135	R:R:K224	R:R:R220	4.95	No	No	0	5	5
136	R:R:H222	R:R:R225	6.77	No	No	0	7	5
137	R:R:I223	R:R:N240	9.91	No	No	0	5	7
138	R:R:G243	R:R:T246	3.64	No	No	0	8	9
139	R:R:I301	R:R:L250	4.28	No	Yes	3	9	8
140	R:R:L250	R:R:Y302	4.69	Yes	Yes	3	8	9
141	R:R:F254	R:R:W258	11.02	No	Yes	0	8	7
142	R:R:C257	R:R:N294	7.87	No	No	0	8	9
143	R:R:I291	R:R:W258	10.57	No	Yes	0	6	7
144	R:R:N294	R:R:W258	9.04	No	Yes	0	9	7
145	R:R:P260	R:R:Y287	6.95	No	Yes	0	9	5
146	R:R:F261	R:R:F262	5.36	Yes	No	0	5	5
147	R:R:F261	R:R:L265	4.87	Yes	No	0	5	5
148	R:R:F261	R:R:F284	6.43	Yes	Yes	1	5	3
149	R:R:F261	R:R:I291	6.28	Yes	No	0	5	6
150	L:L:?4	R:R:F261	5.16	Yes	Yes	1	0	5
151	R:R:F280	R:R:L263	3.65	No	No	0	2	5
152	R:R:H264	R:R:M281	6.57	No	No	0	4	3
153	R:R:F284	R:R:H264	10.18	Yes	No	0	3	4
154	R:R:H264	R:R:Y287	5.44	No	Yes	0	4	5
155	R:R:C271	R:R:F267	5.59	Yes	No	6	5	4
156	R:R:C277	R:R:F267	5.59	No	No	6	6	4
157	R:R:F267	R:R:F280	11.79	No	No	0	4	2
158	L:L:W6	R:R:Y268	13.5	Yes	No	0	0	5
159	R:R:C271	R:R:S270	5.16	Yes	No	0	5	4
160	R:R:C271	R:R:C277	7.28	Yes	No	6	5	6
161	R:R:P272	R:R:Q273	4.74	No	No	0	3	1
162	R:R:N274	R:R:P275	9.77	No	No	0	4	4
163	R:R:C277	R:R:N274	7.87	No	No	0	6	4
164	R:R:F280	R:R:Y287	14.44	No	Yes	0	2	5
165	R:R:H283	R:R:Y287	6.53	No	Yes	0	4	5
166	R:R:F284	R:R:L288	13.4	Yes	No	0	3	4
167	L:L:?4	R:R:F284	5.16	Yes	Yes	1	0	3
168	L:L:K7	R:R:F284	13.65	No	Yes	0	0	3
169	L:L:H3	R:R:N285	20.41	No	No	0	0	4
170	R:R:D298	R:R:N294	13.46	Yes	No	0	9	9
171	R:R:D298	R:R:I301	4.2	Yes	No	3	9	9
172	R:R:I301	R:R:Y302	6.04	No	Yes	3	9	9
173	R:R:F313	R:R:L304	4.87	Yes	No	0	6	6
174	R:R:R305	R:R:R310	4.26	No	No	0	8	8
175	R:R:E308	R:R:S306	4.31	No	No	2	6	7
176	R:R:C319	R:R:Y320	4.03	No	No	0	9	4
177	L:L:?1	L:L:D2	8.91	Yes	No	0	0	0
178	L:L:D2	L:L:K7	20.74	No	No	0	0	0
179	L:L:?4	L:L:R5	5.15	Yes	Yes	1	0	0
180	L:L:?4	L:L:W6	5.79	Yes	Yes	1	0	0
181	L:L:R5	L:L:W6	4	Yes	Yes	1	0	0
182	R:R:F284	R:R:Q43	3.51	Yes	No	0	3	3
183	R:R:P48	R:R:T105	3.5	No	No	0	5	4
184	R:R:A87	R:R:V65	3.39	No	No	0	9	9
185	R:R:A303	R:R:V65	3.39	No	No	0	8	9
186	R:R:A68	R:R:T312	3.36	No	No	0	7	7
187	R:R:L229	R:R:P230	3.28	No	No	0	4	2
188	R:R:L290	R:R:P260	3.28	No	No	0	7	9
189	R:R:C130	R:R:I185	3.27	No	Yes	0	4	5
190	R:R:C138	R:R:I173	3.27	No	No	0	5	5
191	R:R:A87	R:R:I66	3.25	No	No	0	9	7
192	R:R:A239	R:R:I223	3.25	No	No	0	6	5
193	R:R:C293	R:R:L54	3.17	No	Yes	0	4	6
194	R:R:C177	R:R:L134	3.17	No	No	0	7	5
195	R:R:I316	R:R:V67	3.07	No	No	0	7	4
196	R:R:I57	R:R:T53	3.04	No	No	0	5	3
197	R:R:I182	R:R:T178	3.04	No	No	0	3	3
198	R:R:I316	R:R:T312	3.04	No	No	0	7	7
199	R:R:F216	R:R:G243	3.01	No	No	0	6	8
200	R:R:L141	R:R:V145	2.98	No	No	0	7	7
201	R:R:L211	R:R:V145	2.98	No	No	0	7	7
202	R:R:N120	R:R:V119	2.96	No	No	0	1	3
203	R:R:L229	R:R:T232	2.95	No	No	0	4	4
204	R:R:L250	R:R:T246	2.95	Yes	No	0	8	9
205	R:R:I69	R:R:I83	2.94	No	No	0	8	8
206	R:R:I121	R:R:I125	2.94	No	No	0	4	5
207	R:R:I169	R:R:I173	2.94	No	No	0	5	5
208	R:R:I182	R:R:I186	2.94	No	No	0	3	4
209	R:R:I195	R:R:I269	2.94	No	No	0	4	4
210	R:R:I245	R:R:I249	2.94	No	No	0	7	7
211	R:R:I160	R:R:M161	2.92	No	No	0	5	7
212	R:R:I168	R:R:K164	2.91	No	No	0	3	4
213	R:R:E49	R:R:S47	2.87	No	No	0	3	4
214	R:R:L59	R:R:M91	2.83	No	No	0	6	7
215	R:R:I185	R:R:N123	2.83	Yes	No	0	5	5
216	R:R:K224	R:R:L221	2.82	No	No	0	5	5
217	R:R:C196	R:R:F184	2.79	No	Yes	0	5	4
218	R:R:A68	R:R:F313	2.77	No	Yes	0	7	6
219	R:R:A259	R:R:F201	2.77	No	Yes	0	4	6
220	R:R:A244	R:R:F216	2.77	No	No	0	8	6
221	R:R:M241	R:R:Q237	2.72	No	No	0	4	3
222	R:R:L155	R:R:Q156	2.66	No	No	0	8	6
223	R:R:A89	R:R:W174	2.59	No	Yes	0	8	9
224	R:R:F152	R:R:M218	2.49	Yes	No	0	6	5
225	R:R:F184	R:R:M200	2.49	Yes	No	0	4	4
226	R:R:N274	R:R:Y276	2.33	No	No	0	4	3
227	R:R:Q156	R:R:Y153	2.25	No	No	0	6	6
228	R:R:C271	R:R:P272	1.88	Yes	No	0	5	3
229	R:R:G181	R:R:S131	1.86	No	No	0	6	4
230	R:R:G167	R:R:V166	1.84	No	No	0	1	7
231	R:R:G98	R:R:T101	1.82	No	Yes	0	6	6
232	R:R:G231	R:R:T232	1.82	No	No	0	2	4
233	R:R:P48	R:R:S47	1.78	No	No	0	5	4
234	R:R:P48	R:R:T101	1.75	No	Yes	0	5	6
235	R:R:G243	R:R:K242	1.74	No	No	0	8	8
236	R:R:A192	R:R:S190	1.71	No	No	0	5	4
237	R:R:C257	R:R:V253	1.71	No	No	0	8	6
238	R:R:G238	R:R:Q237	1.64	No	No	0	4	3
239	R:R:S47	R:R:V50	1.62	No	No	0	4	4
240	R:R:S99	R:R:V103	1.62	No	No	0	6	3
241	R:R:A209	R:R:I251	1.62	No	No	0	5	7
242	R:R:V52	R:R:V56	1.6	No	No	0	4	4
243	R:R:V124	R:R:V128	1.6	No	No	0	4	4
244	R:R:S131	R:R:T178	1.6	No	No	0	4	3
245	R:R:T101	R:R:V52	1.59	Yes	No	0	6	4
246	R:R:T118	R:R:V119	1.59	No	No	0	6	3
247	R:R:T199	R:R:T203	1.57	No	No	0	4	4
248	R:R:I63	R:R:V67	1.54	No	No	0	4	4
249	R:R:I121	R:R:V103	1.54	No	No	0	4	3
250	R:R:I249	R:R:V253	1.54	No	No	0	7	6
251	R:R:I251	R:R:V255	1.54	No	No	0	7	5
252	R:R:I297	R:R:V253	1.54	No	No	0	7	6
253	R:R:M91	R:R:V95	1.52	No	No	0	7	5
254	R:R:I195	R:R:T199	1.52	No	No	0	4	4
255	R:R:I198	R:R:T199	1.52	No	No	0	5	4
256	R:R:L44	R:R:S282	1.5	No	No	0	2	1
257	R:R:L183	R:R:V179	1.49	No	No	0	5	3
258	R:R:L217	R:R:V213	1.49	No	No	0	4	3
259	R:R:L107	R:R:T118	1.47	No	No	0	4	6
260	R:R:I245	R:R:M241	1.46	No	No	0	7	4
261	R:R:I317	R:R:L64	1.43	No	No	0	5	7
262	R:R:I102	R:R:L106	1.43	No	No	0	6	4
263	R:R:I182	R:R:L183	1.43	No	No	0	3	5
264	R:R:I289	R:R:L286	1.43	Yes	No	0	5	2
265	R:R:L60	R:R:L64	1.38	No	No	0	4	7
266	R:R:F81	R:R:V163	1.31	No	No	0	4	2
267	R:R:N240	R:R:R220	1.21	No	No	0	7	5
268	R:R:L304	R:R:R310	1.21	No	No	0	6	8
269	R:R:I316	R:R:Y320	1.21	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F51	5.996	5	4	6
2	R:R:L54	4.345	4	0	6
3	R:R:L75	8.765	4	2	9
4	R:R:Y80	6.03	6	2	8
5	R:R:L86	4.885	4	3	9
6	R:R:D90	6.3525	4	0	9
7	R:R:E100	6.866	5	1	5
8	R:R:T101	3.235	4	0	6
9	R:R:D126	8.654	5	1	4
10	R:R:Y148	13.14	4	5	8
11	R:R:F152	11.0275	4	5	6
12	R:R:Y157	7.204	5	0	9
13	R:R:W174	4.7475	4	0	9
14	R:R:F184	4.36167	6	0	4
15	R:R:I185	4.67	5	1	5
16	R:R:F201	11.34	4	0	6
17	R:R:Y212	5.195	4	0	9
18	R:R:L250	4.445	4	3	8
19	R:R:W258	7.18333	6	0	7
20	R:R:F261	5.62	5	1	5
21	R:R:C271	4.9775	4	6	5
22	R:R:F284	8.72167	6	1	3
23	R:R:Y287	8.34	4	0	5
24	R:R:I289	4.15	4	4	5
25	R:R:D298	6.79	4	3	9
26	R:R:Y302	5.526	5	3	9
27	R:R:F313	4.46	4	0	6
28	L:L:?1	12.1625	4	1	0
29	L:L:?4	7.70143	7	1	0
30	L:L:R5	6.358	5	1	0
31	L:L:W6	7.538	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F51	R:R:M292	24.838	7.46	Yes	No	0	6	5
2	R:R:M292	R:R:N97	40.3239	8.41	No	No	0	5	6
3	R:R:I129	R:R:N97	41.5219	9.91	No	No	0	5	6
4	L:L:?4	R:R:I129	46.1131	12.09	Yes	No	0	0	5
5	L:L:?4	R:R:F284	11.1671	5.16	Yes	Yes	1	0	3
6	R:R:F284	R:R:H264	27.2494	10.18	Yes	No	0	3	4
7	R:R:H264	R:R:Y287	24.5553	5.44	No	Yes	0	4	5
8	R:R:L54	R:R:M292	15.527	5.65	Yes	No	0	6	5
9	R:R:F51	R:R:T101	16.3393	7.78	Yes	Yes	0	6	6
10	R:R:I296	R:R:L54	10.6478	4.28	No	Yes	0	6	6
11	R:R:F261	R:R:F284	21.8201	6.43	Yes	Yes	1	5	3
12	R:R:F261	R:R:I291	99.7429	6.28	Yes	No	0	5	6
13	R:R:I291	R:R:W258	100	10.57	No	Yes	0	6	7
14	R:R:S136	R:R:W258	54.9871	4.94	No	Yes	0	9	7
15	R:R:D90	R:R:S136	54.2674	4.42	Yes	No	0	9	9
16	R:R:D90	R:R:N62	67.9846	6.73	Yes	No	0	9	9
17	R:R:A87	R:R:N62	64.7764	4.69	No	No	0	9	9
18	R:R:A87	R:R:V65	59.8869	3.39	No	No	0	9	9
19	R:R:F313	R:R:V65	56.5758	6.55	Yes	No	0	6	9
20	R:R:A68	R:R:F313	44.6632	2.77	No	Yes	0	7	6
21	R:R:A68	R:R:T312	42.9203	3.36	No	No	0	7	7
22	R:R:I316	R:R:T312	17.4396	3.04	No	No	0	7	7
23	R:R:I316	R:R:V67	11.7172	3.07	No	No	0	7	4
24	R:R:N72	R:R:T312	24.9254	8.77	No	No	0	7	7
25	R:R:L75	R:R:N72	21.2031	13.73	Yes	No	0	9	7
26	R:R:P78	R:R:Y157	11.2442	4.17	No	Yes	0	6	9
27	R:R:T150	R:R:Y157	34.4319	9.99	No	Yes	0	8	9
28	R:R:I151	R:R:T150	36.1491	4.56	No	No	0	8	8
29	R:R:I151	R:R:M215	55.8303	4.37	No	No	0	8	9
30	R:R:M215	R:R:Y212	80.4833	3.59	No	Yes	0	9	9
31	R:R:M208	R:R:Y212	53.7429	5.99	No	Yes	0	8	9
32	R:R:F254	R:R:M208	54.401	4.98	No	No	0	8	8
33	R:R:F254	R:R:W258	58.3085	11.02	No	Yes	0	8	7
34	R:R:D90	R:R:L86	40.6941	5.43	Yes	Yes	0	9	9
35	R:R:L86	R:R:S139	25.9537	4.5	Yes	No	0	9	8
36	R:R:N294	R:R:W258	30.4216	9.04	No	Yes	0	9	7
37	R:R:D298	R:R:N294	25.1465	13.46	Yes	No	0	9	9
38	R:R:D298	R:R:L86	28.3805	4.07	Yes	Yes	3	9	9
39	R:R:S139	R:R:S85	23.6452	4.89	No	No	0	8	9
40	R:R:S85	R:R:W174	21.3265	4.94	No	Yes	0	9	9
41	L:L:?4	R:R:E100	10.2057	5.61	Yes	Yes	1	0	5
42	L:L:?4	R:R:D126	23.7635	14.95	Yes	Yes	1	0	4
43	R:R:D126	R:R:I185	22.4936	4.2	Yes	Yes	1	4	5
44	L:L:?4	L:L:R5	24.9923	5.15	Yes	Yes	1	0	0
45	L:L:R5	R:R:I185	22.401	3.76	Yes	Yes	1	0	5
46	R:R:C130	R:R:I185	37.6195	3.27	No	Yes	0	4	5
47	R:R:C130	R:R:G181	20.437	3.92	No	No	0	4	6
48	R:R:C130	R:R:F184	15.2237	4.19	No	Yes	0	4	4
49	R:R:A135	R:R:W174	14.3085	7.78	No	Yes	0	7	9
50	R:R:A135	R:R:C177	11.9486	3.61	No	No	0	7	7
51	R:R:L140	R:R:Y302	19.9332	4.69	No	Yes	3	8	9
52	R:R:D298	R:R:I301	27.4344	4.2	Yes	No	3	9	9
53	R:R:F152	R:R:Y148	21.1311	20.63	Yes	Yes	5	6	8
54	R:R:M215	R:R:Y148	24.4987	4.79	No	Yes	0	9	8
55	R:R:F152	R:R:I151	22.072	6.28	Yes	No	0	6	8
56	R:R:M161	R:R:Y157	11.3162	9.58	No	Yes	0	7	9
57	R:R:G181	R:R:S131	17.9177	1.86	No	No	0	6	4
58	R:R:S131	R:R:T178	15.3882	1.6	No	No	0	4	3
59	R:R:I182	R:R:T178	12.8483	3.04	No	No	0	3	3
60	R:R:L250	R:R:Y212	39.9897	5.86	Yes	Yes	0	8	9
61	R:R:I301	R:R:L250	24.545	4.28	No	Yes	3	9	8
62	R:R:G243	R:R:T246	11.635	3.64	No	No	0	8	9
63	R:R:L250	R:R:T246	13.9434	2.95	Yes	No	0	8	9
64	R:R:F152	R:R:M218	38.4216	2.49	Yes	No	0	6	5
65	R:R:L221	R:R:M218	28.0514	5.65	No	No	0	5	5
66	R:R:K224	R:R:L221	24.5656	2.82	No	No	0	5	5
67	R:R:K224	R:R:R220	21.0694	4.95	No	No	0	5	5
68	R:R:N240	R:R:R220	10.5141	1.21	No	No	0	7	5
69	R:R:C257	R:R:N294	14.7609	7.87	No	No	0	8	9
70	R:R:F280	R:R:Y287	16.2211	14.44	No	Yes	0	2	5
71	R:R:F267	R:R:F280	13.3676	11.79	No	No	0	4	2
72	R:R:C257	R:R:V253	12.9512	1.71	No	No	0	8	6
73	L:L:?4	R:R:F261	78.6067	5.16	Yes	Yes	1	0	5
74	R:R:L250	R:R:Y302	17.8612	4.69	Yes	Yes	3	8	9
75	R:R:L140	R:R:L86	17.7378	5.54	No	Yes	3	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F51	R:R:V46	3.93	4	Yes	No	6	5	1	2
R:R:N285	R:R:V46	5.91	0	No	No	4	5	1	2
R:R:I289	R:R:V46	4.61	4	Yes	No	5	5	2	2
R:R:F51	R:R:T101	7.78	4	Yes	Yes	6	6	1	2
R:R:F51	R:R:I289	6.28	4	Yes	Yes	6	5	1	2
R:R:F51	R:R:M292	7.46	4	Yes	No	6	5	1	2
L:L:H3	R:R:F51	4.53	0	No	Yes	0	6	0	1
R:R:I129	R:R:S96	4.64	0	No	No	5	6	1	2
R:R:I129	R:R:N97	9.91	0	No	No	5	6	1	2
R:R:M292	R:R:N97	8.41	0	No	No	5	6	2	2
R:R:D122	R:R:E100	3.9	1	No	Yes	8	5	1	1
R:R:E100	R:R:I125	9.56	1	Yes	No	5	5	1	2
R:R:D126	R:R:E100	7.8	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:E100	7.46	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:E100	5.61	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I104	9.37	1	Yes	No	0	4	0	1
R:R:D122	R:R:D126	7.98	1	No	Yes	8	4	1	1
L:L:?1	R:R:D122	22.91	1	Yes	No	0	8	0	1
R:R:D126	R:R:I185	4.2	1	Yes	Yes	4	5	1	1
L:L:?4	R:R:D126	14.95	1	Yes	Yes	0	4	0	1
L:L:R5	R:R:D126	8.34	1	Yes	Yes	0	4	0	1
R:R:I185	R:R:S127	9.29	1	Yes	No	5	5	1	2
L:L:?4	R:R:I129	12.09	1	Yes	No	0	5	0	1
L:L:R5	R:R:I185	3.76	1	Yes	Yes	0	5	0	1
R:R:D189	R:R:S188	4.42	0	No	No	5	4	2	1
L:L:R5	R:R:S188	10.54	1	Yes	No	0	4	0	1
L:L:W6	R:R:S188	6.18	1	Yes	No	0	4	0	1
R:R:I194	R:R:L265	7.14	0	No	No	4	5	1	2
R:R:I194	R:R:I269	5.89	0	No	No	4	4	1	2
L:L:W6	R:R:I194	8.22	1	Yes	No	0	4	0	1
R:R:F261	R:R:F262	5.36	1	Yes	No	5	5	1	2
R:R:F261	R:R:L265	4.87	1	Yes	No	5	5	1	2
R:R:F261	R:R:F284	6.43	1	Yes	Yes	5	3	1	1
R:R:F261	R:R:I291	6.28	1	Yes	No	5	6	1	2
L:L:?4	R:R:F261	5.16	1	Yes	Yes	0	5	0	1
R:R:F284	R:R:H264	10.18	1	Yes	No	3	4	1	2
L:L:W6	R:R:Y268	13.5	1	Yes	No	0	5	0	1
R:R:F284	R:R:L288	13.4	1	Yes	No	3	4	1	2
L:L:?4	R:R:F284	5.16	1	Yes	Yes	0	3	0	1
L:L:K7	R:R:F284	13.65	0	No	Yes	0	3	0	1
L:L:H3	R:R:N285	20.41	0	No	No	0	4	0	1
R:R:F284	R:R:Q43	3.51	1	Yes	No	3	3	1	2
R:R:C130	R:R:I185	3.27	0	No	Yes	4	5	2	1
R:R:I185	R:R:N123	2.83	1	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F55_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	250
Number of Links	269
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	6
Number of Nodes involved in Communities	32
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	44075
Length Of Smallest Path	3
Average Path Length	13.9782
Length of Longest Path	28
Minimum Path Strength	1.405
Average Path Strength	6.07788
Maximum Path Strength	19.29
Minimum Path Correlation	0.7
Average Path Correlation	0.932667
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	52.135
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.85
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32245
Sequence	>7F55_nogp_Chain_R G C Y E Q L F V S P E V F V T L G V I S L L E N I L V I V A I A K N K N L H S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L N S T S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y A L Q Y H N I M T V K R V G I I I S C I W A A C T V S G I L F I I Y S D S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L P G T Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C P Q N P Y C V C F M S H F N L Y L I L I M C N S I I D P L I Y A L R S Q E L R K T F K E I I C C Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6W25	A	Peptide	Melanocortin	MC₄	Homo sapiens	SHU9119	Ca	-	2.75	2020-04-29	doi.org/10.1126/science.aaz8995
	7F53	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F53 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7PIU	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIU (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7AUE	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	chim(NtGi1L-Gs)/β1/γ2	2.97	2021-04-28	doi.org/10.1126/science.abf7958
	7AUE (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.97	2021-04-28	doi.org/10.1126/science.abf7958
	8WKY	A	Peptide	Melanocortin	MC₄	Homo sapiens	PG-934	-	-	2.9	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8WKZ	A	Peptide	Melanocortin	MC₄	Homo sapiens	SBL-MC-31	-	-	3.3	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8QJ2	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-	Gs	3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	8QJ2 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-		3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	9K3K	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3K (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-		3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7F55_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.