CodeNLE
NameNorleucine
Synonyms
  • L-NORLEUCINE
  • Norleucine
Identifier(2S)-2-aminohexanoic acid
FormulaC6 H13 N O2
Molecular Weight131.173
SMILESCCCC[C@@H](C(=O)O)N
PubChem6991974
Formal Charge0
Total Atoms22
Total Chiral Atoms1
Total Bonds21
Total Aromatic Bonds0
Networks12
 missing image

This ligand is also present in the following 12 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5VBL A Peptide Apelin Apelin Homo sapiens Apelin Mimetic Peptide Agonist - - 2.6 2017-05-31 10.1016/j.str.2017.04.008

A 2D representation of the interactions of NLE in 5VBL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:W24 R:R:Y93 6.75 1 Yes No 1 4 2 2
R:R:M288 R:R:W24 10.47 0 No Yes 4 1 2 2
L:L:K13 R:R:W24 4.64 1 Yes Yes 0 1 2 2
L:L:P16 R:R:W24 14.86 1 Yes Yes 0 1 1 2
L:L:?17 R:R:W85 9.57 1 Yes Yes 0 6 1 2
L:L:?17 R:R:T89 3.72 1 Yes No 0 5 1 2
L:L:P16 R:R:Y93 6.95 1 Yes No 0 4 1 2
L:L:K13 R:R:L173 4.23 1 Yes Yes 0 3 2 2
L:L:?14 R:R:L173 3.74 1 Yes Yes 0 3 1 2
R:R:E198 R:R:Y185 14.59 1 No Yes 4 5 2 2
L:L:?14 R:R:Y185 4.22 1 Yes Yes 0 5 1 2
L:L:?14 R:R:E198 14.31 1 Yes No 0 4 1 2
R:R:K268 R:R:Y264 7.17 1 No Yes 5 6 2 2
R:R:F291 R:R:Y264 4.13 1 Yes Yes 4 6 1 2
L:L:?17 R:R:Y264 8.87 1 Yes Yes 0 6 1 2
R:R:F291 R:R:V267 5.24 1 Yes No 4 4 1 2
L:L:?17 R:R:K268 7.11 1 Yes No 0 5 1 2
R:R:M288 R:R:Y271 4.79 0 No No 4 4 2 1
L:L:K12 R:R:Y271 7.17 0 Yes No 0 4 2 1
L:L:?15 R:R:Y271 14.41 1 Yes No 0 4 0 1
R:R:F291 R:R:T295 7.78 1 Yes No 4 5 1 2
L:L:?15 R:R:F291 24.18 1 Yes Yes 0 4 0 1
L:L:?17 R:R:F291 8.19 1 Yes Yes 0 4 1 1
L:L:?17 R:R:T295 6.19 1 Yes No 0 5 1 2
L:L:?17 R:R:Y299 6.9 1 Yes Yes 0 7 1 2
L:L:?14 L:L:K13 6.35 1 Yes Yes 0 0 1 2
L:L:?14 L:L:?15 18.84 1 Yes Yes 0 0 1 0
L:L:?15 L:L:P16 15.52 1 Yes Yes 0 0 0 1
L:L:?15 L:L:?17 7.7 1 Yes Yes 0 0 0 1
L:L:?17 L:L:P16 5.52 1 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength16.13
Average Nodes In Shell21.00
Average Hubs In Shell13.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6FJ3 B1 Peptide Parathyroid hormone PTH1 Homo sapiens PTH - - 2.5 2018-11-21 10.1038/s41594-018-0151-4

A 2D representation of the interactions of NLE in 6FJ3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:W14 R:R:E180 9.81 0 Yes No 0 3 1 2
L:L:W14 R:R:R181 6 0 Yes No 0 3 1 2
L:L:W14 R:R:F184 7.02 0 Yes No 0 6 1 2
L:L:L15 L:L:W14 3.42 0 No Yes 0 0 2 1
L:L:?18 L:L:W14 8.61 0 No Yes 0 0 0 1
L:L:?18 L:L:S17 4.26 0 No No 0 0 0 1
L:L:R20 L:L:S17 5.27 2 Yes No 0 0 2 1
L:L:?18 L:L:E22 2.51 0 No No 0 0 0 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.13
Average Nodes In Shell9.00
Average Hubs In Shell2.00
Average Links In Shell8.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W25 A Peptide Melanocortin MC4 Homo sapiens SHU9119 Ca - 2.75 2020-04-29 10.1126/science.aaz8995

A 2D representation of the interactions of NLE in 6W25
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:I104 5.4 0 No No 0 4 0 1
L:L:H3 R:R:I104 9.28 6 Yes No 0 4 2 1
R:R:D122 R:R:D126 10.65 1 No Yes 8 4 1 2
R:R:D122 W:W:?100 7.48 1 No Yes 8 0 1 2
L:L:?1 R:R:D122 16.68 0 No No 0 8 0 1
R:R:D126 W:W:?100 7.48 1 Yes Yes 4 0 2 2
R:R:I104 R:R:N108 2.83 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength11.04
Average Nodes In Shell7.00
Average Hubs In Shell3.00
Average Links In Shell7.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4F A Peptide Melanocortin MC1 Homo sapiens Afamelanotide - chim(NtGi1-Gs)/Beta1/Gamma2 2.9 2021-09-08 10.1038/s41422-021-00557-y

A 2D representation of the interactions of NLE in 7F4F
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D117 R:R:E94 3.9 2 Yes Yes 6 4 1 2
R:R:D121 R:R:E94 6.5 2 Yes Yes 5 4 2 2
R:R:D117 R:R:D121 10.65 2 Yes Yes 6 5 1 2
L:L:?4 R:R:D117 8.98 0 No Yes 0 6 0 1
L:L:R8 R:R:D117 7.15 2 Yes Yes 0 6 2 1
L:L:R8 R:R:D121 14.29 2 Yes Yes 0 5 2 2
L:L:?4 L:L:S3 4.26 0 No No 0 0 0 1
L:L:?4 L:L:E5 5.01 0 No No 0 0 0 1
L:L:E5 L:L:K11 13.5 0 No No 0 0 1 2
L:L:S3 L:L:Y2 1.27 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.08
Average Nodes In Shell9.00
Average Hubs In Shell4.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4H A Peptide Melanocortin MC1 Homo sapiens Afamelanotide - chim(NtGi1-Gs)/Beta1/Gamma2 2.7 2021-09-08 10.1038/s41422-021-00557-y

A 2D representation of the interactions of NLE in 7F4H
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E102 R:R:I98 5.47 0 No No 3 3 2 1
L:L:?4 R:R:I98 8.1 0 Yes No 0 3 0 1
L:L:H6 R:R:I98 5.3 2 Yes No 0 3 2 1
R:R:D117 R:R:D121 9.31 2 No Yes 6 5 1 2
L:L:?4 R:R:D117 12.83 0 Yes No 0 6 0 1
L:L:R8 R:R:D117 5.96 2 Yes No 0 6 2 1
L:L:R8 R:R:D121 14.29 2 Yes Yes 0 5 2 2
L:L:?4 L:L:E5 5.01 0 Yes No 0 0 0 1
L:L:E5 L:L:K11 5.4 0 No No 0 0 1 2
R:R:L116 R:R:V97 2.98 0 No No 3 4 2 1
L:L:?4 R:R:V97 2.82 0 Yes No 0 4 0 1
L:L:?4 L:L:S3 1.42 0 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub0.00
Average Interaction Strength6.04
Average Nodes In Shell12.00
Average Hubs In Shell4.00
Average Links In Shell12.00
Average Links Mediated by Hubs In Shell9.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4I A Peptide Melanocortin MC1 Homo sapiens SHU9119 - chim(NtGi1-Gs)/Beta1/Gamma2 3.1 2021-09-08 10.1038/s41422-021-00557-y

A 2D representation of the interactions of NLE in 7F4I
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E94 R:R:I98 4.1 5 Yes Yes 4 3 2 1
R:R:D121 R:R:E94 5.2 5 Yes Yes 5 4 2 2
L:L:?1 R:R:I98 10.79 0 No Yes 0 3 0 1
L:L:H3 R:R:I98 7.95 0 No Yes 0 3 2 1
R:R:L101 R:R:L113 4.15 0 No No 3 6 2 1
L:L:?1 R:R:L113 5.23 0 No No 0 6 0 1
R:R:D117 R:R:D121 9.31 0 No Yes 6 5 1 2
L:L:?1 R:R:D117 15.4 0 No No 0 6 0 1
R:R:E102 R:R:I98 2.73 0 No Yes 3 3 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength10.47
Average Nodes In Shell9.00
Average Hubs In Shell3.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F54 A Peptide Melanocortin MC4 Homo sapiens Afamelanotide - Gs/Beta1/Gamma2 3 2021-11-03 10.1038/s41422-021-00552-3

A 2D representation of the interactions of NLE in 7F54
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D122 R:R:E100 3.9 5 No Yes 8 5 1 1
R:R:E100 R:R:I125 9.56 5 Yes No 5 5 1 2
R:R:D126 R:R:E100 7.8 5 Yes Yes 4 5 2 1
L:L:?4 R:R:E100 7.52 5 Yes Yes 0 5 0 1
L:L:?7 R:R:E100 5.64 5 Yes Yes 0 5 2 1
L:L:?4 R:R:I104 13.49 5 Yes No 0 4 0 1
R:R:D122 R:R:D126 6.65 5 No Yes 8 4 1 2
L:L:?4 R:R:D122 23.09 5 Yes No 0 8 0 1
L:L:?7 R:R:D126 11.55 5 Yes Yes 0 4 2 2
L:L:?4 L:L:S3 8.52 5 Yes No 0 0 0 1
L:L:?4 L:L:E5 11.27 5 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub1.00
Average Interaction Strength12.78
Average Nodes In Shell9.00
Average Hubs In Shell4.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F55 A Peptide Melanocortin MC4 Homo sapiens Bremelanotide - Gs/Beta1/Gamma2 3.1 2021-11-03 10.1038/s41422-021-00552-3

A 2D representation of the interactions of NLE in 7F55
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D122 R:R:E100 3.9 4 No Yes 8 5 1 1
R:R:E100 R:R:I125 9.56 4 Yes No 5 5 1 2
R:R:D126 R:R:E100 7.8 4 Yes Yes 4 5 2 1
L:L:?1 R:R:E100 7.52 4 Yes Yes 0 5 0 1
L:L:?4 R:R:E100 5.64 4 Yes Yes 0 5 2 1
L:L:?1 R:R:I104 9.45 4 Yes No 0 4 0 1
R:R:D122 R:R:D126 7.98 4 No Yes 8 4 1 2
L:L:?1 R:R:D122 23.09 4 Yes No 0 8 0 1
L:L:?4 R:R:D126 15.02 4 Yes Yes 0 4 2 2
L:L:?1 L:L:D2 8.98 4 Yes No 0 0 0 1
L:L:D2 L:L:K7 19.36 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub1.00
Average Interaction Strength12.26
Average Nodes In Shell9.00
Average Hubs In Shell4.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8X A Peptide Cholecystokinin CCKA Homo sapiens NN9056 - - 3 2021-12-29 10.1038/s41589-021-00866-8

A 2D representation of the interactions of NLE in 7F8X
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F107 R:R:P101 5.78 1 Yes Yes 8 5 2 2
L:L:?2 R:R:P101 3.66 1 Yes Yes 0 5 1 2
L:L:?2 R:R:N102 7.15 1 Yes No 0 6 1 2
L:L:?2 R:R:K105 6.29 1 Yes No 0 4 1 2
L:L:?2 R:R:F107 5.43 1 Yes Yes 0 8 1 2
R:R:M195 R:R:R197 16.13 1 Yes Yes 4 4 2 1
L:L:?2 R:R:M195 11.57 1 Yes Yes 0 4 1 2
L:L:?2 R:R:R197 11.75 1 Yes Yes 0 4 1 1
L:L:?3 R:R:R197 8.04 1 Yes Yes 0 4 0 1
L:L:G4 R:R:R197 4.5 1 Yes Yes 0 4 1 1
R:R:E344 R:R:R336 10.47 1 Yes No 1 4 1 2
L:L:G4 R:R:R336 4.5 1 Yes No 0 4 1 2
L:L:W5 R:R:R336 17.99 1 Yes No 0 4 2 2
R:R:E344 R:R:T340 5.64 1 Yes No 1 2 1 2
L:L:?3 R:R:E344 13.78 1 Yes Yes 0 1 0 1
L:L:G4 R:R:E344 6.55 1 Yes Yes 0 1 1 1
L:L:?3 R:R:S348 8.52 1 Yes No 0 5 0 1
L:L:?2 L:L:?3 15.57 1 Yes Yes 0 0 1 0
L:L:?2 L:L:?6 8.76 1 Yes Yes 0 0 1 2
L:L:?3 L:L:G4 4.85 1 Yes Yes 0 0 0 1
L:L:G4 L:L:W5 5.63 1 Yes Yes 0 0 1 2
L:L:?6 L:L:W5 9.69 1 Yes Yes 0 0 2 2
L:L:?2 L:L:D1 2.02 1 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.15
Average Nodes In Shell16.00
Average Hubs In Shell10.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NLE in 7F8X
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C94 R:R:M121 8.1 0 No Yes 7 7 2 1
R:R:F107 R:R:P101 5.78 1 Yes Yes 8 5 2 2
L:L:?2 R:R:P101 3.66 1 Yes Yes 0 5 1 2
L:L:?2 R:R:N102 7.15 1 Yes No 0 6 1 2
L:L:?2 R:R:K105 6.29 1 Yes No 0 4 1 2
L:L:?2 R:R:F107 5.43 1 Yes Yes 0 8 1 2
L:L:?6 R:R:M121 4.01 1 Yes Yes 0 7 0 1
L:L:?8 R:R:M121 8.45 1 Yes Yes 0 7 1 1
L:L:?9 R:R:M121 14.09 1 Yes Yes 0 7 2 1
R:R:F198 R:R:Y176 19.6 1 Yes Yes 5 7 2 2
L:L:?7 R:R:Y176 7.89 1 Yes Yes 0 7 1 2
L:L:?8 R:R:Y176 10.01 1 Yes Yes 0 7 1 2
R:R:M195 R:R:R197 16.13 1 Yes Yes 4 4 2 2
L:L:?2 R:R:M195 11.57 1 Yes Yes 0 4 1 2
L:L:?2 R:R:R197 11.75 1 Yes Yes 0 4 1 2
L:L:?3 R:R:R197 8.04 1 Yes Yes 0 4 2 2
L:L:G4 R:R:R197 4.5 1 Yes Yes 0 4 2 2
L:L:?7 R:R:F198 4.55 1 Yes Yes 0 5 1 2
R:R:I329 R:R:N333 7.08 1 No Yes 7 7 2 2
R:R:I329 R:R:L356 4.28 1 No No 7 6 2 2
L:L:?8 R:R:I329 3.66 1 Yes No 0 7 1 2
L:L:?8 R:R:F330 10.4 1 Yes Yes 0 7 1 2
L:L:W5 R:R:N333 6.78 1 Yes Yes 0 7 1 2
L:L:?7 R:R:N333 7.18 1 Yes Yes 0 7 1 2
L:L:?8 R:R:N333 5.86 1 Yes Yes 0 7 1 2
L:L:G4 R:R:R336 4.5 1 Yes No 0 4 2 2
L:L:W5 R:R:R336 17.99 1 Yes No 0 4 1 2
L:L:W5 R:R:I352 14.09 1 Yes No 0 5 1 2
L:L:?8 R:R:L356 4.73 1 Yes No 0 6 1 2
L:L:?2 L:L:?3 15.57 1 Yes Yes 0 0 1 2
L:L:?2 L:L:?6 8.76 1 Yes Yes 0 0 1 0
L:L:?3 L:L:G4 4.85 1 Yes Yes 0 0 2 2
L:L:G4 L:L:W5 5.63 1 Yes Yes 0 0 2 1
L:L:?6 L:L:W5 9.69 1 Yes Yes 0 0 0 1
L:L:?6 L:L:?7 23.47 1 Yes Yes 0 0 0 1
L:L:?6 L:L:?8 11.18 1 Yes Yes 0 0 0 1
L:L:?7 L:L:?8 34.46 1 Yes Yes 0 0 1 1
L:L:?7 L:L:?9 5.16 1 Yes Yes 0 0 1 2
L:L:?8 L:L:?9 20.62 1 Yes Yes 0 0 1 2
L:L:?2 L:L:D1 2.02 1 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.42
Average Nodes In Shell25.00
Average Hubs In Shell17.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7PIV A Peptide Melanocortin MC4 Homo sapiens Setmelanotide - Gs/Beta1/Gamma2 2.86 2021-11-17 10.1038/s41422-021-00569-8

A 2D representation of the interactions of NLE in 7PIV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D122 R:R:E100 3.9 2 No Yes 8 5 1 1
R:R:E100 R:R:I125 8.2 2 Yes No 5 5 1 2
R:R:D126 R:R:E100 5.2 2 Yes Yes 4 5 2 1
L:L:?4 R:R:E100 5.01 2 Yes Yes 0 5 0 1
L:L:?7 R:R:E100 3.38 2 Yes Yes 0 5 2 1
R:R:L107 R:R:V103 4.47 0 No No 4 3 1 2
R:R:I125 R:R:V103 3.07 0 No No 5 3 2 2
R:R:I104 R:R:T105 3.04 0 No No 4 4 1 2
L:L:?4 R:R:I104 6.75 2 Yes No 0 4 0 1
L:L:?4 R:R:L107 3.93 2 Yes No 0 4 0 1
R:R:D122 R:R:D126 6.65 2 No Yes 8 4 1 2
L:L:?4 R:R:D122 16.68 2 Yes No 0 8 0 1
L:L:?7 R:R:D126 4.62 2 Yes Yes 0 4 2 2
L:L:?4 L:L:E5 5.01 2 Yes No 0 0 0 1
L:L:E5 L:L:K11 6.75 0 No Yes 0 0 1 2
L:L:?4 L:L:S3 2.84 2 Yes No 0 0 0 1
L:L:S3 L:L:Y2 2.54 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.70
Average Nodes In Shell14.00
Average Hubs In Shell5.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7QA8 D1 Ste2-like STE2 STE2 Saccharomyces cerevisiae Peptide - - 2.7 2022-03-16 10.1038/s41586-022-04498-3

A 2D representation of the interactions of NLE in 7QA8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:L4 M:M:Y13 3.52 2 Yes Yes 0 0 2 1
M:M:L4 S:S:F204 4.87 2 Yes Yes 0 5 2 1
M:M:L4 S:S:N205 5.49 2 Yes No 0 6 2 2
M:M:L4 S:S:D275 5.43 2 Yes No 0 5 2 2
M:M:L4 S:S:T278 2.95 2 Yes No 0 5 2 2
M:M:L6 M:M:Q10 5.32 2 Yes Yes 0 0 2 2
M:M:L6 M:M:Y13 2.34 2 Yes Yes 0 0 2 1
M:M:L6 S:S:D201 10.86 2 Yes No 0 2 2 2
M:M:L6 S:S:F204 8.53 2 Yes Yes 0 5 2 1
M:M:P11 M:M:Q10 3.16 2 Yes Yes 0 0 1 2
M:M:Q10 M:M:Y13 3.38 2 Yes Yes 0 0 2 1
M:M:Q10 S:S:Y98 3.38 2 Yes Yes 0 6 2 2
M:M:Q10 S:S:Y101 5.64 2 Yes Yes 0 6 2 2
M:M:?12 M:M:P11 6.21 2 Yes Yes 0 0 0 1
M:M:P11 S:S:Y98 9.74 2 Yes Yes 0 6 1 2
M:M:P11 S:S:Y101 9.74 2 Yes Yes 0 6 1 2
M:M:P11 S:S:Y128 5.56 2 Yes No 0 8 1 2
M:M:P11 S:S:T131 6.99 2 Yes No 0 6 1 2
M:M:P11 S:S:N132 3.26 2 Yes Yes 0 7 1 1
M:M:?12 M:M:Y13 4.43 2 Yes Yes 0 0 0 1
M:M:?12 S:S:H94 4.86 2 Yes Yes 0 8 0 1
M:M:?12 S:S:N132 10.38 2 Yes Yes 0 7 0 1
M:M:?12 S:S:Q135 8.81 2 Yes Yes 0 6 0 1
M:M:?12 S:S:S184 2.84 2 Yes No 0 5 0 1
M:M:?12 S:S:F204 5.76 2 Yes Yes 0 5 0 1
M:M:Y13 S:S:Y98 3.97 2 Yes Yes 0 6 1 2
M:M:Y13 S:S:Q135 3.38 2 Yes Yes 0 6 1 1
M:M:Y13 S:S:F204 8.25 2 Yes Yes 0 5 1 1
M:M:Y13 S:S:D275 4.6 2 Yes No 0 5 1 2
M:M:Y13 S:S:T278 2.5 2 Yes No 0 5 1 2
M:M:Y13 S:S:T279 3.75 2 Yes Yes 0 7 1 2
S:S:F55 S:S:H94 3.39 2 Yes Yes 6 8 2 1
S:S:F55 S:S:Y98 8.25 2 Yes Yes 6 6 2 2
S:S:F55 S:S:T279 2.59 2 Yes Yes 6 7 2 2
S:S:H94 S:S:Y98 3.27 2 Yes Yes 8 6 1 2
S:S:H94 S:S:T131 2.74 2 Yes No 8 6 1 2
S:S:H94 S:S:Q135 7.42 2 Yes Yes 8 6 1 1
S:S:Y101 S:S:Y98 7.94 2 Yes Yes 6 6 2 2
S:S:N132 S:S:Y128 13.96 2 Yes No 7 8 1 2
S:S:M189 S:S:N132 2.8 0 No Yes 5 7 2 1
S:S:Q135 S:S:V139 2.87 2 Yes No 6 6 1 2
S:S:Q135 S:S:Y181 6.76 2 Yes Yes 6 7 1 2
S:S:V139 S:S:Y181 13.88 2 No Yes 6 7 2 2
S:S:S184 S:S:Y203 2.54 0 No Yes 5 5 1 2
S:S:D201 S:S:F204 4.78 2 No Yes 2 5 2 1
S:S:D201 S:S:N205 4.04 2 No No 2 6 2 2
S:S:F204 S:S:N205 3.62 2 Yes No 5 6 1 2
S:S:F204 S:S:T208 2.59 2 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.18
Average Nodes In Shell26.00
Average Hubs In Shell16.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NLE in 7QA8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F55 R:R:H94 3.39 1 Yes Yes 6 8 2 1
R:R:F55 R:R:Y98 8.25 1 Yes Yes 6 6 2 2
R:R:F55 R:R:T279 2.59 1 Yes Yes 6 7 2 2
R:R:H94 R:R:Y98 3.27 1 Yes Yes 8 6 1 2
R:R:H94 R:R:T131 2.74 1 Yes No 8 6 1 2
R:R:H94 R:R:Q135 7.42 1 Yes Yes 8 6 1 1
L:L:?12 R:R:H94 6.08 1 Yes Yes 0 8 0 1
L:L:Y13 R:R:H94 2.18 1 Yes Yes 0 8 1 1
R:R:Y101 R:R:Y98 7.94 1 Yes Yes 6 6 2 2
L:L:Q10 R:R:Y98 3.38 1 Yes Yes 0 6 2 2
L:L:P11 R:R:Y98 9.74 1 Yes Yes 0 6 1 2
L:L:Y13 R:R:Y98 3.97 1 Yes Yes 0 6 1 2
L:L:Q10 R:R:Y101 6.76 1 Yes Yes 0 6 2 2
L:L:P11 R:R:Y101 11.13 1 Yes Yes 0 6 1 2
R:R:N132 R:R:Y128 13.96 1 Yes No 7 8 1 2
L:L:P11 R:R:Y128 4.17 1 Yes No 0 8 1 2
L:L:P11 R:R:T131 10.49 1 Yes No 0 6 1 2
R:R:M189 R:R:N132 2.8 0 No Yes 5 7 2 1
L:L:P11 R:R:N132 3.26 1 Yes Yes 0 7 1 1
L:L:?12 R:R:N132 12.98 1 Yes Yes 0 7 0 1
R:R:Q135 R:R:V139 2.87 1 Yes No 6 6 1 2
R:R:Q135 R:R:Y181 6.76 1 Yes Yes 6 7 1 2
L:L:?12 R:R:Q135 8.81 1 Yes Yes 0 6 0 1
L:L:Y13 R:R:Q135 3.38 1 Yes Yes 0 6 1 1
R:R:V139 R:R:Y181 13.88 1 No Yes 6 7 2 2
R:R:S184 R:R:Y203 2.54 0 No Yes 5 5 1 2
L:L:?12 R:R:S184 2.84 1 Yes No 0 5 0 1
R:R:D201 R:R:F204 4.78 1 No Yes 2 5 2 1
R:R:D201 R:R:N205 2.69 1 No No 2 6 2 2
L:L:L6 R:R:D201 10.86 1 Yes No 0 2 2 2
R:R:F204 R:R:N205 3.62 1 Yes No 5 6 1 2
R:R:F204 R:R:T208 2.59 1 Yes No 5 6 1 2
L:L:L4 R:R:F204 6.09 1 Yes Yes 0 5 2 1
L:L:L6 R:R:F204 7.31 1 Yes Yes 0 5 2 1
L:L:?12 R:R:F204 4.61 1 Yes Yes 0 5 0 1
L:L:Y13 R:R:F204 7.22 1 Yes Yes 0 5 1 1
L:L:L4 R:R:N205 5.49 1 Yes No 0 6 2 2
L:L:L4 R:R:D275 4.07 1 Yes No 0 5 2 2
L:L:Y13 R:R:D275 4.6 1 Yes No 0 5 1 2
L:L:L4 R:R:T278 2.95 1 Yes No 0 5 2 2
L:L:Y13 R:R:T278 2.5 1 Yes No 0 5 1 2
L:L:Y13 R:R:T279 2.5 1 Yes Yes 0 7 1 2
L:L:L4 L:L:Y13 3.52 1 Yes Yes 0 0 2 1
L:L:L6 L:L:Q10 5.32 1 Yes Yes 0 0 2 2
L:L:L6 L:L:Y13 2.34 1 Yes Yes 0 0 2 1
L:L:P11 L:L:Q10 3.16 1 Yes Yes 0 0 1 2
L:L:Q10 L:L:Y13 3.38 1 Yes Yes 0 0 2 1
L:L:?12 L:L:P11 6.21 1 Yes Yes 0 0 0 1
L:L:?12 L:L:Y13 4.43 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.57
Average Nodes In Shell26.00
Average Hubs In Shell16.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IOD A Peptide Melanocortin MC5 Homo Sapiens PG-901 Ca chim(NtGi1-Gs)/Beta1/Gamma2 2.59 2023-09-20 10.1038/s41421-023-00586-4

A 2D representation of the interactions of NLE in 8IOD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?0 L:L:?1 21.6 5 Yes Yes 0 0 1 0
L:L:?0 R:R:V111 4.47 5 Yes No 0 3 1 1
L:L:?0 R:R:D115 16.29 5 Yes Yes 0 8 1 1
L:L:?1 R:R:T95 5.57 5 Yes No 0 4 0 1
L:L:?1 R:R:I96 14.84 5 Yes Yes 0 4 0 1
L:L:?1 R:R:V111 4.23 5 Yes No 0 3 0 1
L:L:?1 R:R:D115 16.68 5 Yes Yes 0 8 0 1
L:L:P3 R:R:I96 5.08 24 No Yes 0 4 2 1
R:R:E92 R:R:I96 4.1 5 Yes Yes 6 4 2 1
R:R:D115 R:R:E92 3.9 5 Yes Yes 8 6 1 2
R:R:E92 R:R:F118 7 5 Yes Yes 6 6 2 2
R:R:D119 R:R:E92 9.09 5 Yes Yes 4 6 2 2
I:I:?1 R:R:E92 7.3 5 Yes Yes 0 6 2 2
R:R:F118 R:R:T95 6.49 0 Yes No 6 4 2 1
R:R:L99 R:R:V111 4.47 0 No No 2 3 2 1
R:R:D115 R:R:D119 11.98 5 Yes Yes 8 4 1 2
I:I:?1 R:R:D115 7.48 5 Yes Yes 0 8 2 1
I:I:?1 R:R:D119 7.48 5 Yes Yes 0 4 2 2
L:L:?0 R:R:R112 1.82 5 Yes No 0 3 1 2
R:R:I96 R:R:N100 1.42 0 Yes No 4 3 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength12.58
Average Nodes In Shell14.00
Average Hubs In Shell8.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links4.64
Average Number Of Links With An Hub2.43
Average Interaction Strength9.54
Average Nodes In Shell14.71
Average Hubs In Shell7.79
Average Links In Shell21.07
Average Links Mediated by Hubs In Shell19.29

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)