psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C279	R:R:C40	5.46	No	No	0	4	2
2	L:L:K11	R:R:Q43	4.07	Yes	No	0	0	3
3	R:R:H283	R:R:L44	10.29	No	No	0	4	2
4	R:R:V46	R:R:V50	4.81	No	No	0	5	4
5	R:R:F51	R:R:V46	5.24	Yes	No	0	6	5
6	R:R:I289	R:R:V46	4.61	No	No	0	5	5
7	R:R:P48	R:R:S47	5.34	No	No	0	5	4
8	R:R:E49	R:R:S47	11.5	No	No	0	3	4
9	R:R:E49	R:R:V50	5.7	No	No	0	3	4
10	R:R:F51	R:R:T101	14.27	Yes	No	3	6	6
11	R:R:F51	R:R:M292	4.98	Yes	No	0	6	5
12	L:L:H6	R:R:F51	21.5	No	Yes	3	0	6
13	R:R:L54	R:R:M292	4.24	No	No	0	6	5
14	R:R:G55	R:R:S94	3.71	No	No	0	6	8
15	R:R:S58	R:R:S94	6.52	No	No	0	8	8
16	R:R:S295	R:R:S58	4.89	No	No	0	9	8
17	R:R:I296	R:R:S58	4.64	No	No	0	6	8
18	R:R:E61	R:R:P299	4.72	No	No	0	8	9
19	R:R:E61	R:R:L300	3.98	No	No	0	8	6
20	R:R:D90	R:R:N62	5.39	Yes	No	0	9	9
21	R:R:M91	R:R:N62	5.61	No	No	0	7	9
22	R:R:N62	R:R:P299	4.89	No	No	0	9	9
23	R:R:F313	R:R:L64	12.18	No	No	0	6	7
24	R:R:P299	R:R:V65	3.53	No	No	0	9	9
25	R:R:A303	R:R:V65	3.39	No	No	0	8	9
26	R:R:C84	R:R:I66	3.27	No	No	0	5	7
27	R:R:K71	R:R:V67	6.07	No	No	0	5	4
28	R:R:I69	R:R:L75	4.28	No	Yes	0	8	9
29	R:R:C84	R:R:I69	3.27	No	No	0	5	8
30	R:R:N72	R:R:N74	8.17	No	No	4	7	6
31	R:R:L75	R:R:N72	9.61	Yes	No	4	9	7
32	R:R:N72	R:R:T312	11.7	No	No	0	7	7
33	R:R:L75	R:R:N74	9.61	Yes	No	4	9	6
34	R:R:L75	R:R:Y80	7.03	Yes	Yes	0	9	8
35	R:R:F81	R:R:H76	14.71	No	No	0	4	8
36	R:R:P78	R:R:S77	3.56	No	No	0	6	7
37	R:R:S77	R:R:Y80	5.09	No	Yes	0	7	8
38	R:R:M161	R:R:P78	3.35	No	No	0	7	6
39	R:R:P78	R:R:V166	3.53	No	No	0	6	7
40	R:R:M79	R:R:Y80	4.79	No	Yes	0	8	8
41	R:R:D146	R:R:M79	4.16	No	No	0	9	8
42	R:R:M79	R:R:R147	7.44	No	No	0	8	9
43	R:R:S306	R:R:Y80	6.36	No	Yes	0	7	8
44	R:R:F81	R:R:V166	5.24	No	No	0	4	7
45	R:R:D146	R:R:F82	8.36	No	Yes	0	9	8
46	R:R:F82	R:R:I170	5.02	Yes	No	0	8	7
47	R:R:S139	R:R:S85	4.89	No	No	0	8	9
48	R:R:S85	R:R:W174	4.94	No	Yes	0	9	9
49	R:R:D90	R:R:L86	9.5	Yes	Yes	2	9	9
50	R:R:L86	R:R:S139	7.51	Yes	No	0	9	8
51	R:R:L140	R:R:L86	8.3	No	Yes	2	8	9
52	R:R:I143	R:R:L86	4.28	No	Yes	2	9	9
53	R:R:D298	R:R:L86	8.14	No	Yes	2	9	9
54	R:R:L86	R:R:Y302	3.52	Yes	Yes	2	9	9
55	R:R:V88	R:R:W174	6.13	No	Yes	0	6	9
56	R:R:A89	R:R:S136	3.42	No	No	0	8	9
57	R:R:D90	R:R:S136	4.42	Yes	No	0	9	9
58	R:R:D90	R:R:S295	4.42	Yes	No	0	9	9
59	R:R:D298	R:R:D90	13.31	No	Yes	2	9	9
60	R:R:L92	R:R:S132	10.51	No	No	0	6	6
61	R:R:S96	R:R:V128	4.85	No	No	0	6	4
62	R:R:I129	R:R:S96	6.19	No	No	0	5	6
63	R:R:M292	R:R:N97	9.82	No	No	0	5	6
64	R:R:D122	R:R:E100	3.9	No	Yes	1	8	5
65	R:R:E100	R:R:I125	8.2	Yes	No	0	5	5
66	R:R:D126	R:R:E100	5.2	Yes	Yes	1	4	5
67	L:L:?4	R:R:E100	4.97	Yes	Yes	1	0	5
68	L:L:?7	R:R:E100	3.37	Yes	Yes	1	0	5
69	L:L:H6	R:R:T101	6.85	No	No	3	0	6
70	R:R:L107	R:R:V103	4.47	No	No	0	4	3
71	L:L:?4	R:R:I104	6.69	Yes	No	0	0	4
72	L:L:?4	R:R:L107	3.89	Yes	No	0	0	4
73	R:R:I121	R:R:N120	9.91	No	No	0	4	1
74	R:R:D122	R:R:D126	6.65	No	Yes	1	8	4
75	L:L:?4	R:R:D122	16.54	Yes	No	1	0	8
76	R:R:I185	R:R:N123	4.25	Yes	No	0	5	5
77	R:R:D126	R:R:I185	4.2	Yes	Yes	1	4	5
78	L:L:?7	R:R:D126	4.6	Yes	Yes	1	0	4
79	L:L:R8	R:R:D126	14.29	Yes	Yes	1	0	4
80	R:R:I182	R:R:S127	7.74	No	No	0	3	5
81	R:R:I185	R:R:S127	9.29	Yes	No	0	5	5
82	L:L:?7	R:R:I129	13.3	Yes	No	0	0	5
83	R:R:C130	R:R:G181	3.92	No	No	0	4	6
84	R:R:C130	R:R:I185	6.55	No	Yes	0	4	5
85	R:R:G181	R:R:S131	3.71	No	No	0	6	4
86	R:R:L133	R:R:W258	5.69	No	Yes	0	5	7
87	R:R:A135	R:R:W174	7.78	No	Yes	0	7	9
88	R:R:A135	R:R:C177	3.61	No	No	0	7	7
89	R:R:S136	R:R:W258	4.94	No	Yes	0	9	7
90	R:R:I137	R:R:M204	4.37	No	No	0	6	6
91	R:R:I137	R:R:W258	10.57	No	Yes	0	6	7
92	R:R:C138	R:R:I173	3.27	No	No	0	5	5
93	R:R:C138	R:R:C177	3.64	No	No	0	5	7
94	R:R:L140	R:R:Y302	4.69	No	Yes	2	8	9
95	R:R:L141	R:R:M204	5.65	No	No	0	7	6
96	R:R:I143	R:R:Y302	4.84	No	Yes	2	9	9
97	R:R:A144	R:R:Y212	5.34	No	Yes	0	9	9
98	R:R:D146	R:R:Y157	6.9	No	Yes	0	9	9
99	R:R:R147	R:R:Y212	8.23	No	Yes	0	9	9
100	R:R:R147	R:R:Y302	5.14	No	Yes	0	9	9
101	R:R:F152	R:R:Y148	23.73	Yes	No	5	6	8
102	R:R:L211	R:R:Y148	7.03	No	No	0	7	8
103	R:R:H214	R:R:Y148	10.89	No	No	5	4	8
104	R:R:F149	R:R:Y153	8.25	No	No	0	6	6
105	R:R:T150	R:R:Y157	8.74	No	Yes	0	8	9
106	R:R:F152	R:R:I151	3.77	Yes	No	0	6	8
107	R:R:I151	R:R:M215	4.37	No	No	0	8	9
108	R:R:F152	R:R:H214	14.71	Yes	No	5	6	4
109	R:R:F152	R:R:M218	9.95	Yes	No	0	6	5
110	R:R:N159	R:R:Q156	3.96	No	No	0	5	6
111	R:R:H158	R:R:Y157	4.36	No	Yes	0	6	9
112	R:R:M161	R:R:Y157	11.97	No	Yes	0	7	9
113	R:R:I160	R:R:N159	4.25	No	No	0	5	5
114	R:R:R165	R:R:T162	7.76	No	No	0	6	8
115	R:R:F184	R:R:V193	7.87	Yes	No	0	4	5
116	R:R:F184	R:R:L197	4.87	Yes	No	0	4	5
117	L:L:R8	R:R:I185	5.01	Yes	Yes	1	0	5
118	R:R:I186	R:R:Y187	6.04	No	No	0	4	4
119	R:R:S190	R:R:Y187	5.09	No	No	0	4	4
120	L:L:R8	R:R:S188	9.22	Yes	No	1	0	4
121	L:L:W9	R:R:S188	3.71	Yes	No	1	0	4
122	R:R:I194	R:R:L265	4.28	Yes	Yes	1	4	5
123	R:R:I194	R:R:Y268	3.63	Yes	No	1	4	5
124	R:R:I194	R:R:I269	10.3	Yes	No	1	4	4
125	L:L:W9	R:R:I194	9.4	Yes	Yes	1	0	4
126	R:R:I195	R:R:I269	5.89	No	No	1	4	4
127	L:L:W9	R:R:L197	3.42	Yes	No	0	0	5
128	R:R:I198	R:R:I266	10.3	No	No	0	5	5
129	R:R:F201	R:R:F202	4.29	Yes	No	0	6	4
130	R:R:F201	R:R:F254	5.36	Yes	Yes	0	6	8
131	R:R:F201	R:R:F262	34.29	Yes	No	0	6	5
132	R:R:F254	R:R:L205	6.09	Yes	No	0	8	6
133	R:R:M208	R:R:Y212	4.79	No	Yes	0	8	9
134	R:R:F254	R:R:M208	4.98	Yes	No	0	8	8
135	R:R:M215	R:R:Y212	3.59	No	Yes	0	9	9
136	R:R:L250	R:R:Y212	4.69	No	Yes	0	8	9
137	R:R:F216	R:R:L247	6.09	No	No	0	6	8
138	R:R:L221	R:R:M218	4.24	No	No	0	5	5
139	R:R:H222	R:R:R225	7.9	No	No	0	7	5
140	R:R:I223	R:R:N240	4.25	No	No	0	5	7
141	R:R:I251	R:R:L247	4.28	Yes	No	0	7	8
142	R:R:L250	R:R:Y302	4.69	No	Yes	0	8	9
143	R:R:I297	R:R:V253	4.61	No	No	2	7	6
144	R:R:I301	R:R:V253	4.61	Yes	No	2	9	6
145	R:R:F254	R:R:W258	7.02	Yes	Yes	0	8	7
146	R:R:I291	R:R:W258	9.4	No	Yes	0	6	7
147	R:R:N294	R:R:W258	11.3	No	Yes	0	9	7
148	R:R:L290	R:R:P260	3.28	No	No	0	7	9
149	R:R:F261	R:R:F262	5.36	Yes	No	1	5	5
150	R:R:F261	R:R:L265	9.74	Yes	Yes	1	5	5
151	R:R:F261	R:R:I291	5.02	Yes	No	0	5	6
152	R:R:F262	R:R:L265	3.65	No	Yes	1	5	5
153	R:R:F280	R:R:L263	3.65	No	No	0	2	5
154	R:R:H264	R:R:M281	10.51	No	No	0	4	3
155	R:R:F284	R:R:H264	13.58	Yes	No	0	3	4
156	L:L:W9	R:R:L265	4.56	Yes	Yes	1	0	5
157	R:R:C271	R:R:F267	4.19	Yes	No	0	5	4
158	R:R:F267	R:R:F280	11.79	No	No	0	4	2
159	L:L:W9	R:R:Y268	5.79	Yes	No	1	0	5
160	R:R:C271	R:R:C277	7.28	Yes	No	0	5	6
161	R:R:P272	R:R:Q273	7.9	No	No	0	3	1
162	R:R:N274	R:R:P275	6.52	No	No	0	4	4
163	R:R:N274	R:R:Y276	11.63	No	No	0	4	3
164	R:R:C277	R:R:N274	7.87	No	No	0	6	4
165	R:R:F280	R:R:Y287	16.5	No	No	0	2	5
166	R:R:F284	R:R:L288	7.31	Yes	No	0	3	4
167	L:L:G10	R:R:F284	10.54	No	Yes	0	0	3
168	L:L:H6	R:R:N285	3.83	No	No	0	0	4
169	R:R:D298	R:R:N294	12.12	No	No	0	9	9
170	R:R:I297	R:R:I301	4.42	No	Yes	2	7	9
171	R:R:L300	R:R:L304	4.15	No	No	0	6	6
172	R:R:I301	R:R:Y302	4.84	Yes	Yes	2	9	9
173	R:R:A303	R:R:L309	4.73	No	No	0	8	8
174	R:R:F313	R:R:L304	8.53	No	No	0	6	6
175	R:R:L309	R:R:S306	6.01	No	No	0	8	7
176	R:R:Q307	R:R:R310	4.67	No	No	0	4	8
177	R:R:K311	R:R:Q307	14.92	No	No	0	4	4
178	R:R:K314	R:R:R310	4.95	No	No	0	5	8
179	L:L:?4	L:L:E5	4.97	Yes	No	0	0	0
180	L:L:E5	L:L:K11	6.75	No	Yes	0	0	0
181	L:L:?7	L:L:R8	6.18	Yes	Yes	1	0	0
182	L:L:R8	L:L:W9	9	Yes	Yes	1	0	0
183	L:L:K11	L:L:P12	5.02	Yes	No	0	0	0
184	R:R:A209	R:R:I251	3.25	No	Yes	0	5	7
185	R:R:F261	R:R:F284	3.22	Yes	Yes	0	5	3
186	R:R:S131	R:R:T178	3.2	No	No	0	4	3
187	R:R:R305	R:R:R310	3.2	No	No	0	8	8
188	R:R:T118	R:R:V119	3.17	No	No	0	6	3
189	R:R:C177	R:R:L134	3.17	No	No	0	7	5
190	R:R:C257	R:R:N294	3.15	No	No	0	8	9
191	R:R:I104	R:R:T105	3.04	No	No	0	4	4
192	R:R:M281	R:R:V278	3.04	No	No	0	3	1
193	R:R:F216	R:R:G243	3.01	No	No	0	6	8
194	R:R:L134	R:R:S180	3	No	No	0	5	4
195	R:R:L211	R:R:V145	2.98	No	No	0	7	7
196	R:R:L205	R:R:V255	2.98	No	No	0	6	5
197	R:R:L250	R:R:T246	2.95	No	No	0	8	9
198	R:R:I296	R:R:I57	2.94	No	No	0	6	5
199	R:R:I182	R:R:I186	2.94	No	No	0	3	4
200	R:R:I194	R:R:I198	2.94	Yes	No	0	4	5
201	R:R:I249	R:R:I301	2.94	No	Yes	0	7	9
202	R:R:I63	R:R:M91	2.92	No	No	0	4	7
203	R:R:I102	R:R:L106	2.85	No	No	0	6	4
204	R:R:I226	R:R:L229	2.85	No	No	0	6	4
205	R:R:L59	R:R:M91	2.83	No	No	0	6	7
206	L:L:?4	L:L:S3	2.82	Yes	No	0	0	0
207	R:R:C196	R:R:F184	2.79	No	Yes	0	5	4
208	R:R:P260	R:R:Y287	2.78	No	No	0	9	5
209	R:R:L141	R:R:L207	2.77	No	No	0	7	5
210	R:R:A259	R:R:F201	2.77	No	Yes	0	4	6
211	R:R:A244	R:R:F216	2.77	No	No	0	8	6
212	R:R:L286	R:R:L290	2.77	No	No	0	2	7
213	R:R:L288	R:R:N97	2.75	No	No	0	4	6
214	R:R:E308	R:R:L75	2.65	No	Yes	0	6	9
215	R:R:F82	R:R:S142	2.64	Yes	No	0	8	7
216	R:R:F149	R:R:V145	2.62	No	No	0	6	7
217	R:R:E308	R:R:Q307	2.55	No	No	0	6	4
218	L:L:S3	L:L:Y2	2.54	No	No	0	0	0
219	R:R:F82	R:R:I169	2.51	Yes	No	0	8	5
220	R:R:F149	R:R:I160	2.51	No	No	0	6	5
221	R:R:F267	R:R:I266	2.51	No	No	0	4	5
222	R:R:F184	R:R:M200	2.49	Yes	No	0	4	4
223	R:R:I251	R:R:Y212	2.42	Yes	Yes	0	7	9
224	R:R:L183	R:R:Y187	2.34	No	No	0	5	4
225	R:R:L92	R:R:W174	2.28	No	Yes	0	6	9
226	R:R:H283	R:R:Y287	2.18	No	No	0	4	5
227	R:R:C271	R:R:P272	1.88	Yes	No	0	5	3
228	R:R:G243	R:R:K242	1.74	No	No	0	8	8
229	R:R:C271	R:R:S270	1.72	Yes	No	0	5	4
230	R:R:A87	R:R:V65	1.7	No	No	0	9	9
231	R:R:A68	R:R:T312	1.68	No	No	0	7	7
232	R:R:L229	R:R:P230	1.64	No	No	0	4	2
233	R:R:C293	R:R:I289	1.64	No	No	0	4	5
234	R:R:A303	R:R:I83	1.62	No	No	0	8	8
235	R:R:S132	R:R:V93	1.62	No	No	0	6	8
236	R:R:S295	R:R:V93	1.62	No	No	0	9	8
237	R:R:S99	R:R:V103	1.62	No	No	0	6	3
238	R:R:T199	R:R:T203	1.57	No	No	0	4	4
239	R:R:I195	R:R:S191	1.55	No	No	1	4	4
240	R:R:I269	R:R:S191	1.55	No	No	1	4	4
241	R:R:I102	R:R:V52	1.54	No	No	0	6	4
242	R:R:I57	R:R:V56	1.54	No	No	0	5	4
243	R:R:I316	R:R:V67	1.54	No	No	0	7	4
244	R:R:I251	R:R:V213	1.54	Yes	No	0	7	3
245	R:R:I195	R:R:T199	1.52	No	No	0	4	4
246	R:R:I316	R:R:T312	1.52	No	No	0	7	7
247	L:L:K11	L:L:V13	1.52	Yes	No	0	0	0
248	R:R:L44	R:R:S282	1.5	No	No	0	2	1
249	R:R:K164	R:R:T162	1.5	No	No	0	4	8
250	R:R:L59	R:R:V95	1.49	No	No	0	6	5
251	R:R:L92	R:R:V95	1.49	No	No	0	6	5
252	R:R:L217	R:R:V213	1.49	No	No	0	4	3
253	R:R:I121	R:R:I125	1.47	No	No	0	4	5
254	R:R:I168	R:R:I169	1.47	No	No	0	3	5
255	R:R:D189	R:R:S188	1.47	No	No	0	5	4
256	R:R:D189	R:R:S190	1.47	No	No	0	5	4
257	R:R:I245	R:R:I249	1.47	No	No	0	7	7
258	R:R:I245	R:R:M241	1.46	No	No	0	7	4
259	R:R:I168	R:R:K164	1.45	No	No	0	3	4
260	R:R:I63	R:R:L60	1.43	No	No	0	4	4
261	R:R:F81	R:R:V163	1.31	No	No	0	4	2
262	L:L:S1	L:L:Y2	1.27	No	No	0	0	0
263	R:R:F45	R:R:N285	1.21	No	No	0	3	4
264	R:R:N240	R:R:R220	1.21	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F51	11.4975	4	3	6
2	R:R:L75	6.636	5	4	9
3	R:R:Y80	5.8175	4	0	8
4	R:R:F82	4.6325	4	0	8
5	R:R:L86	6.875	6	2	9
6	R:R:D90	7.408	5	2	9
7	R:R:E100	5.128	5	1	5
8	R:R:D126	6.988	5	1	4
9	R:R:F152	13.04	4	5	6
10	R:R:Y157	7.9925	4	0	9
11	R:R:W174	5.2825	4	0	9
12	R:R:F184	4.505	4	0	4
13	R:R:I185	5.86	5	1	5
14	R:R:I194	6.11	5	1	4
15	R:R:F201	11.6775	4	0	6
16	R:R:Y212	4.84333	6	0	9
17	R:R:I251	2.8725	4	0	7
18	R:R:F254	5.8625	4	0	8
19	R:R:W258	8.15333	6	0	7
20	R:R:F261	5.835	4	1	5
21	R:R:L265	5.5575	4	1	5
22	R:R:C271	3.7675	4	0	5
23	R:R:F284	8.6625	4	0	3
24	R:R:I301	4.2025	4	2	9
25	R:R:Y302	4.62	6	2	9
26	L:L:?4	6.64667	6	1	0
27	L:L:?7	6.8625	4	1	0
28	L:L:R8	8.74	5	1	0
29	L:L:W9	5.98	6	1	0
30	L:L:K11	4.34	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E5	L:L:K11	19.2494	6.75	No	Yes	0	0	0
2	L:L:?4	L:L:E5	24.1164	4.97	Yes	No	0	0	0
3	L:L:?4	R:R:E100	44.692	4.97	Yes	Yes	1	0	5
4	R:R:D126	R:R:E100	28.8774	5.2	Yes	Yes	1	4	5
5	L:L:R8	R:R:D126	51.8268	14.29	Yes	Yes	1	0	4
6	L:L:R8	L:L:W9	97.8582	9	Yes	Yes	1	0	0
7	L:L:W9	R:R:I194	13.3015	9.4	Yes	Yes	1	0	4
8	R:R:I194	R:R:I198	36.7946	2.94	Yes	No	0	4	5
9	R:R:I198	R:R:I266	35.0773	10.3	No	No	0	5	5
10	R:R:F267	R:R:I266	33.3466	2.51	No	No	0	4	5
11	R:R:F267	R:R:F280	17.1739	11.79	No	No	0	4	2
12	R:R:F280	R:R:Y287	13.4209	16.5	No	No	0	2	5
13	L:L:?4	R:R:D122	22.6245	16.54	Yes	No	1	0	8
14	R:R:D122	R:R:D126	24.1761	6.65	No	Yes	1	8	4
15	L:L:?7	R:R:E100	27.9358	3.37	Yes	Yes	1	0	5
16	L:L:?7	L:L:R8	33.5787	6.18	Yes	Yes	1	0	0
17	L:L:W9	R:R:L265	100	4.56	Yes	Yes	1	0	5
18	R:R:F261	R:R:L265	71.978	9.74	Yes	Yes	1	5	5
19	R:R:F261	R:R:F284	46.0049	3.22	Yes	Yes	0	5	3
20	R:R:F284	R:R:L288	35.6077	7.31	Yes	No	0	3	4
21	R:R:L288	R:R:N97	33.466	2.75	No	No	0	4	6
22	R:R:M292	R:R:N97	31.4767	9.82	No	No	0	5	6
23	R:R:F51	R:R:M292	27.107	4.98	Yes	No	0	6	5
24	R:R:F51	R:R:V46	16.1461	5.24	Yes	No	0	6	5
25	R:R:F261	R:R:I291	78.8542	5.02	Yes	No	0	5	6
26	R:R:I291	R:R:W258	78.9868	9.4	No	Yes	0	6	7
27	R:R:S136	R:R:W258	47.6891	4.94	No	Yes	0	9	7
28	R:R:D90	R:R:S136	46.6282	4.42	Yes	No	0	9	9
29	R:R:D90	R:R:S295	17.1739	4.42	Yes	No	0	9	9
30	R:R:S295	R:R:S58	11.3321	4.89	No	No	0	9	8
31	R:R:D90	R:R:N62	26.8285	5.39	Yes	No	0	9	9
32	R:R:N62	R:R:P299	18.52	4.89	No	No	0	9	9
33	R:R:E61	R:R:P299	10.1386	4.72	No	No	0	8	9
34	R:R:M91	R:R:N62	10.5497	5.61	No	No	0	7	9
35	R:R:F262	R:R:L265	63.212	3.65	No	Yes	1	5	5
36	R:R:F201	R:R:F262	74.2391	34.29	Yes	No	0	6	5
37	R:R:F201	R:R:F254	74.7165	5.36	Yes	Yes	0	6	8
38	R:R:F254	R:R:M208	85.9028	4.98	Yes	No	0	8	8
39	R:R:M208	R:R:Y212	85.3524	4.79	No	Yes	0	8	9
40	R:R:R147	R:R:Y212	65.4201	8.23	No	Yes	0	9	9
41	R:R:M79	R:R:R147	63.7093	7.44	No	No	0	8	9
42	R:R:M79	R:R:Y80	44.0289	4.79	No	Yes	0	8	8
43	R:R:L75	R:R:Y80	31.3308	7.03	Yes	Yes	0	9	8
44	R:R:L75	R:R:N72	11.4515	9.61	Yes	No	4	9	7
45	R:R:S77	R:R:Y80	11.226	5.09	No	Yes	0	7	8
46	R:R:D146	R:R:M79	23.4335	4.16	No	No	0	9	8
47	R:R:D146	R:R:F82	15.0322	8.36	No	Yes	0	9	8
48	R:R:D90	R:R:L86	35.1966	9.5	Yes	Yes	2	9	9
49	R:R:L86	R:R:S139	28.7713	7.51	Yes	No	0	9	8
50	R:R:N294	R:R:W258	21.8619	11.3	No	Yes	0	9	7
51	R:R:D298	R:R:N294	20.801	12.12	No	No	0	9	9
52	R:R:D298	R:R:L86	20.2042	8.14	No	Yes	2	9	9
53	R:R:S139	R:R:S85	26.0526	4.89	No	No	0	8	9
54	R:R:S85	R:R:W174	23.3605	4.94	No	Yes	0	9	9
55	R:R:L86	R:R:Y302	37.292	3.52	Yes	Yes	2	9	9
56	L:L:?4	R:R:L107	14.7139	3.89	Yes	No	0	0	4
57	R:R:A135	R:R:W174	17.5784	7.78	No	Yes	0	7	9
58	R:R:A135	R:R:C177	14.6807	3.61	No	No	0	7	7
59	R:R:M215	R:R:Y212	29.7195	3.59	No	Yes	0	9	9
60	R:R:I151	R:R:M215	27.6573	4.37	No	No	0	8	9
61	R:R:F152	R:R:I151	25.7609	3.77	Yes	No	0	6	8
62	R:R:F152	R:R:Y148	17.3397	23.73	Yes	No	5	6	8
63	R:R:L211	R:R:Y148	15.2642	7.03	No	No	0	7	8
64	R:R:L211	R:R:V145	13.1225	2.98	No	No	0	7	7
65	R:R:F149	R:R:V145	10.9674	2.62	No	No	0	6	7
66	R:R:L250	R:R:Y212	16.239	4.69	No	Yes	0	8	9
67	R:R:I251	R:R:Y212	19.2626	2.42	Yes	Yes	0	7	9
68	R:R:I251	R:R:L247	10.7818	4.28	Yes	No	0	7	8
69	R:R:I301	R:R:Y302	25.3896	4.84	Yes	Yes	2	9	9
70	R:R:R147	R:R:Y302	25.8007	5.14	No	Yes	0	9	9
71	R:R:L250	R:R:Y302	14.4022	4.69	No	Yes	0	8	9
72	R:R:C271	R:R:F267	15.377	4.19	Yes	No	0	5	4
73	R:R:E308	R:R:L75	11.4913	2.65	No	Yes	0	6	9
74	R:R:I249	R:R:I301	12.6384	2.94	No	Yes	0	7	9
75	L:L:?4	L:L:S3	14.7139	2.82	Yes	No	0	0	0
76	R:R:I194	R:R:L265	34.5468	4.28	Yes	Yes	1	4	5
77	L:L:R8	R:R:I185	13.7789	5.01	Yes	Yes	1	0	5
78	R:R:F261	R:R:F262	11.2658	5.36	Yes	No	1	5	5
79	R:R:F254	R:R:W258	17.2601	7.02	Yes	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K11	R:R:Q43	4.07	0	Yes	No	0	3	0	1
R:R:F51	R:R:V46	5.24	3	Yes	No	6	5	1	2
R:R:F51	R:R:T101	14.27	3	Yes	No	6	6	1	1
R:R:F51	R:R:M292	4.98	3	Yes	No	6	5	1	2
L:L:H6	R:R:F51	21.5	3	No	Yes	0	6	0	1
R:R:I129	R:R:S96	6.19	0	No	No	5	6	1	2
R:R:D122	R:R:E100	3.9	1	No	Yes	8	5	1	1
R:R:E100	R:R:I125	8.2	1	Yes	No	5	5	1	2
R:R:D126	R:R:E100	5.2	1	Yes	Yes	4	5	1	1
L:L:?4	R:R:E100	4.97	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:E100	3.37	1	Yes	Yes	0	5	0	1
L:L:H6	R:R:T101	6.85	3	No	No	0	6	0	1
R:R:L107	R:R:V103	4.47	0	No	No	4	3	1	2
L:L:?4	R:R:I104	6.69	1	Yes	No	0	4	0	1
L:L:?4	R:R:L107	3.89	1	Yes	No	0	4	0	1
R:R:D122	R:R:D126	6.65	1	No	Yes	8	4	1	1
L:L:?4	R:R:D122	16.54	1	Yes	No	0	8	0	1
R:R:I185	R:R:N123	4.25	1	Yes	No	5	5	1	2
R:R:D126	R:R:I185	4.2	1	Yes	Yes	4	5	1	1
L:L:?7	R:R:D126	4.6	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:D126	14.29	1	Yes	Yes	0	4	0	1
R:R:I185	R:R:S127	9.29	1	Yes	No	5	5	1	2
L:L:?7	R:R:I129	13.3	1	Yes	No	0	5	0	1
R:R:C130	R:R:I185	6.55	0	No	Yes	4	5	2	1
R:R:F184	R:R:L197	4.87	0	Yes	No	4	5	2	1
L:L:R8	R:R:I185	5.01	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:S188	9.22	1	Yes	No	0	4	0	1
L:L:W9	R:R:S188	3.71	1	Yes	No	0	4	0	1
R:R:I194	R:R:L265	4.28	1	Yes	Yes	4	5	1	1
R:R:I194	R:R:Y268	3.63	1	Yes	No	4	5	1	1
R:R:I194	R:R:I269	10.3	1	Yes	No	4	4	1	2
L:L:W9	R:R:I194	9.4	1	Yes	Yes	0	4	0	1
L:L:W9	R:R:L197	3.42	1	Yes	No	0	5	0	1
R:R:F261	R:R:F262	5.36	1	Yes	No	5	5	2	2
R:R:F261	R:R:L265	9.74	1	Yes	Yes	5	5	2	1
R:R:F262	R:R:L265	3.65	1	No	Yes	5	5	2	1
R:R:F284	R:R:H264	13.58	0	Yes	No	3	4	1	2
L:L:W9	R:R:L265	4.56	1	Yes	Yes	0	5	0	1
L:L:W9	R:R:Y268	5.79	1	Yes	No	0	5	0	1
R:R:F284	R:R:L288	7.31	0	Yes	No	3	4	1	2
L:L:G10	R:R:F284	10.54	0	No	Yes	0	3	0	1
L:L:H6	R:R:N285	3.83	3	No	No	0	4	0	1
R:R:F261	R:R:F284	3.22	1	Yes	Yes	5	3	2	1
R:R:I104	R:R:T105	3.04	0	No	No	4	4	1	2
R:R:I194	R:R:I198	2.94	1	Yes	No	4	5	1	2
R:R:D189	R:R:S188	1.47	0	No	No	5	4	2	1
R:R:F45	R:R:N285	1.21	0	No	No	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7PIV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.27
Number of Linked Nodes	245
Number of Links	264
Number of Hubs	30
Number of Links mediated by Hubs	118
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	40533
Length Of Smallest Path	3
Average Path Length	13.0117
Length of Longest Path	26
Minimum Path Strength	1.46
Average Path Strength	6.57969
Maximum Path Strength	19.825
Minimum Path Correlation	0.7
Average Path Correlation	0.930989
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	47.9213
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4351
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • multicellular organismal process • system process • circulatory system process
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • regulation of localization • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • localization • regulation of steroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • transport • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • cell-cell signaling • endocrine process • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • extracellular region
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • fibroblast proliferation • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • melanocyte-stimulating hormone receptor activity • regulation of behavior • behavior • regulation of eating behavior • eating behavior • feeding behavior • regulation of feeding behavior • response to insulin • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • tissue remodeling • bone remodeling • anatomical structure homeostasis • positive regulation of bone resorption • response to melanocyte-stimulating hormone • response to nutrient levels • response to food
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32245
Sequence	>7PIV_nogp_Chain_R C Y E Q L F V S P E V F V T L G V I S L L E N I L V I V A I A K N K N L H S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L N T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y A L Q Y H N I M T V K R V G I I I S C I W A A C T V S G I L F I I Y S D S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L P A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C P Q N P Y C V C F M S H F N L Y L I L I M C N S I I D P L I Y A L R S Q E L R K T F K E I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6W25	A	Peptide	Melanocortin	MC₄	Homo sapiens	SHU9119	Ca	-	2.75	2020-04-29	doi.org/10.1126/science.aaz8995
	7F53	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F53 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7PIU	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIU (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7AUE	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	chim(NtGi1L-Gs)/β1/γ2	2.97	2021-04-28	doi.org/10.1126/science.abf7958
	7AUE (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.97	2021-04-28	doi.org/10.1126/science.abf7958
	8WKY	A	Peptide	Melanocortin	MC₄	Homo sapiens	PG-934	-	-	2.9	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8WKZ	A	Peptide	Melanocortin	MC₄	Homo sapiens	SBL-MC-31	-	-	3.3	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8QJ2	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-	Gs	3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	8QJ2 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-		3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	9K3K	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3K (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-		3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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