psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R2	R:R:D122	4.76	No	No	0	0	8
2	L:L:?9	L:L:C3	14.31	Yes	No	0	0	0
3	L:L:?4	L:L:H5	6.54	No	No	0	0	0
4	L:L:?4	R:R:I104	5.81	No	No	0	0	4
5	L:L:H5	R:R:F51	18.1	No	Yes	4	0	6
6	L:L:H5	R:R:T101	6.85	No	Yes	4	0	6
7	L:L:?6	L:L:R7	7.21	Yes	Yes	2	0	0
8	L:L:?6	R:R:E100	5.61	Yes	No	2	0	5
9	L:L:?6	R:R:D126	10.35	Yes	Yes	2	0	4
10	L:L:?6	R:R:I129	15.72	Yes	No	0	0	5
11	L:L:?6	R:R:L288	3.52	Yes	No	0	0	4
12	L:L:R7	R:R:D126	5.96	Yes	Yes	2	0	4
13	L:L:R7	R:R:I185	6.26	Yes	No	0	0	5
14	L:L:R7	R:R:S188	9.22	Yes	No	0	0	4
15	L:L:W8	R:R:S188	8.65	No	No	0	0	4
16	L:L:W8	R:R:I194	5.87	No	No	0	0	4
17	L:L:?9	R:R:Q43	6	Yes	No	1	0	3
18	L:L:?9	R:R:H264	4.35	Yes	Yes	1	0	4
19	L:L:?9	R:R:Y268	3.96	Yes	No	0	0	5
20	L:L:?9	R:R:F284	12.35	Yes	Yes	1	0	3
21	R:R:C279	R:R:C40	7.28	No	No	0	4	2
22	R:R:C40	R:R:S282	3.44	No	No	0	2	1
23	R:R:P275	R:R:Y41	5.56	No	No	0	4	6
24	R:R:V278	R:R:Y41	17.66	No	No	0	1	6
25	R:R:F284	R:R:Q43	3.51	Yes	No	1	3	3
26	R:R:N285	R:R:V46	2.96	No	No	0	4	5
27	R:R:P48	R:R:S47	3.56	No	No	0	5	4
28	R:R:E49	R:R:V52	11.41	No	No	0	3	4
29	R:R:F51	R:R:T101	7.78	Yes	Yes	4	6	6
30	R:R:F51	R:R:I289	5.02	Yes	No	0	6	5
31	R:R:F51	R:R:M292	3.73	Yes	No	0	6	5
32	R:R:N62	R:R:S58	4.47	Yes	No	0	9	8
33	R:R:S58	R:R:S94	6.52	No	No	0	8	8
34	R:R:S295	R:R:S58	4.89	No	No	0	9	8
35	R:R:E61	R:R:I296	5.47	No	No	0	8	6
36	R:R:E61	R:R:P299	7.86	No	No	0	8	9
37	R:R:A87	R:R:N62	3.13	No	Yes	0	9	9
38	R:R:D90	R:R:N62	4.04	Yes	Yes	0	9	9
39	R:R:N62	R:R:P299	6.52	Yes	No	0	9	9
40	R:R:I63	R:R:M91	4.37	No	No	0	4	7
41	R:R:F313	R:R:L64	6.09	No	No	0	6	7
42	R:R:A303	R:R:V65	3.39	Yes	No	0	8	9
43	R:R:A87	R:R:I66	3.25	No	No	0	9	7
44	R:R:A68	R:R:T312	3.36	No	No	0	7	7
45	R:R:K71	R:R:T312	3	No	No	0	5	7
46	R:R:I316	R:R:K71	5.82	No	No	0	7	5
47	R:R:N72	R:R:N74	5.45	No	No	0	7	6
48	R:R:L75	R:R:N72	5.49	No	No	0	9	7
49	R:R:N72	R:R:T312	10.24	No	No	0	7	7
50	R:R:H76	R:R:K73	6.55	No	No	0	8	5
51	R:R:E308	R:R:N74	11.83	No	No	0	6	6
52	R:R:L75	R:R:Y80	14.07	No	Yes	0	9	8
53	R:R:L309	R:R:L75	4.15	Yes	No	0	8	9
54	R:R:F81	R:R:H76	3.39	No	No	0	4	8
55	R:R:P78	R:R:V166	3.53	No	No	0	6	7
56	R:R:M79	R:R:Y80	10.78	No	Yes	0	8	8
57	R:R:S306	R:R:Y80	7.63	No	Yes	0	7	8
58	R:R:F82	R:R:S142	7.93	No	No	0	8	7
59	R:R:D146	R:R:F82	8.36	No	No	0	9	8
60	R:R:F82	R:R:I170	3.77	No	No	0	8	7
61	R:R:S139	R:R:S85	3.26	No	No	0	8	9
62	R:R:I170	R:R:S85	6.19	No	No	0	7	9
63	R:R:S85	R:R:W174	4.94	No	Yes	0	9	9
64	R:R:L86	R:R:S139	3	No	No	0	9	8
65	R:R:L140	R:R:L86	4.15	No	No	0	8	9
66	R:R:D298	R:R:L86	4.07	No	No	0	9	9
67	R:R:V88	R:R:W174	3.68	No	Yes	0	6	9
68	R:R:D90	R:R:S136	4.42	Yes	No	0	9	9
69	R:R:D90	R:R:S295	10.31	Yes	No	0	9	9
70	R:R:D298	R:R:D90	3.99	No	Yes	0	9	9
71	R:R:L92	R:R:S132	6.01	No	No	0	6	6
72	R:R:S132	R:R:V93	3.23	No	No	0	6	8
73	R:R:L133	R:R:V93	2.98	No	No	0	5	8
74	R:R:S96	R:R:V128	6.46	No	No	0	6	4
75	R:R:I129	R:R:N97	4.25	No	No	0	5	6
76	R:R:M292	R:R:N97	5.61	No	No	0	5	6
77	R:R:E100	R:R:I125	6.83	No	No	0	5	5
78	R:R:D126	R:R:E100	9.09	Yes	No	2	4	5
79	R:R:I102	R:R:T105	3.04	No	No	0	6	4
80	R:R:L107	R:R:V103	5.96	No	No	0	4	3
81	R:R:D122	R:R:D126	9.31	No	Yes	0	8	4
82	R:R:I185	R:R:S127	10.84	No	No	0	5	5
83	R:R:C130	R:R:F184	4.19	No	Yes	0	4	4
84	R:R:G181	R:R:S131	3.71	No	No	0	6	4
85	R:R:L133	R:R:W258	4.56	No	Yes	0	5	7
86	R:R:C177	R:R:L134	3.17	Yes	No	0	7	5
87	R:R:A135	R:R:W174	7.78	No	Yes	0	7	9
88	R:R:A135	R:R:C177	3.61	No	Yes	0	7	7
89	R:R:S136	R:R:W258	3.71	No	Yes	0	9	7
90	R:R:I137	R:R:W258	9.4	No	Yes	0	6	7
91	R:R:L140	R:R:Y302	3.52	No	Yes	0	8	9
92	R:R:L141	R:R:L207	4.15	No	No	0	7	5
93	R:R:I143	R:R:Y302	3.63	No	Yes	0	9	9
94	R:R:A144	R:R:Y212	4	No	Yes	0	9	9
95	R:R:F149	R:R:V145	3.93	No	No	0	6	7
96	R:R:D146	R:R:Y157	5.75	No	Yes	0	9	9
97	R:R:R147	R:R:Y212	6.17	No	Yes	0	9	9
98	R:R:R147	R:R:Y302	6.17	No	Yes	0	9	9
99	R:R:F152	R:R:Y148	17.54	Yes	Yes	6	6	8
100	R:R:L211	R:R:Y148	7.03	No	Yes	0	7	8
101	R:R:H214	R:R:Y148	7.62	No	Yes	6	4	8
102	R:R:M215	R:R:Y148	3.59	No	Yes	0	9	8
103	R:R:F149	R:R:Y153	4.13	No	No	0	6	6
104	R:R:T150	R:R:Y157	7.49	No	Yes	0	8	9
105	R:R:F152	R:R:I151	6.28	Yes	No	0	6	8
106	R:R:I151	R:R:M215	4.37	No	No	0	8	9
107	R:R:F152	R:R:H214	14.71	Yes	No	6	6	4
108	R:R:F152	R:R:M218	6.22	Yes	No	0	6	5
109	R:R:H158	R:R:Y157	6.53	No	Yes	0	6	9
110	R:R:M161	R:R:Y157	9.58	No	Yes	0	7	9
111	R:R:R165	R:R:T162	3.88	No	No	0	6	8
112	R:R:G167	R:R:V166	3.68	No	No	0	1	7
113	R:R:F184	R:R:S180	3.96	Yes	No	0	4	4
114	R:R:F184	R:R:V193	5.24	Yes	No	0	4	5
115	R:R:C196	R:R:F184	4.19	No	Yes	0	5	4
116	R:R:F184	R:R:L197	7.31	Yes	No	0	4	5
117	R:R:I186	R:R:Y187	6.04	No	No	0	4	4
118	R:R:I194	R:R:V193	3.07	No	No	0	4	5
119	R:R:I194	R:R:I269	8.83	No	No	0	4	4
120	R:R:C196	R:R:M200	3.24	No	No	0	5	4
121	R:R:I198	R:R:I266	7.36	No	No	0	5	5
122	R:R:F201	R:R:F202	9.65	Yes	No	0	6	4
123	R:R:F201	R:R:F254	5.36	Yes	No	3	6	8
124	R:R:F201	R:R:W258	3.01	Yes	Yes	3	6	7
125	R:R:F201	R:R:F262	23.58	Yes	No	3	6	5
126	R:R:F254	R:R:L205	4.87	No	No	0	8	6
127	R:R:M208	R:R:Y212	3.59	No	Yes	0	8	9
128	R:R:L250	R:R:Y212	3.52	No	Yes	0	8	9
129	R:R:F216	R:R:N240	6.04	No	No	0	6	7
130	R:R:F216	R:R:L247	6.09	No	No	0	6	8
131	R:R:I223	R:R:N240	5.66	No	No	0	5	7
132	R:R:L229	R:R:P230	3.28	No	No	0	4	2
133	R:R:G243	R:R:N240	5.09	No	No	0	8	7
134	R:R:G243	R:R:T246	3.64	No	No	0	8	9
135	R:R:L250	R:R:T246	2.95	No	No	0	8	9
136	R:R:I297	R:R:V253	4.61	No	No	0	7	6
137	R:R:F254	R:R:W258	4.01	No	Yes	3	8	7
138	R:R:C257	R:R:N294	4.72	No	No	0	8	9
139	R:R:F262	R:R:W258	3.01	No	Yes	3	5	7
140	R:R:N294	R:R:W258	12.43	No	Yes	0	9	7
141	R:R:P260	R:R:Y287	4.17	No	Yes	0	9	5
142	R:R:L290	R:R:P260	3.28	No	No	0	7	9
143	R:R:F261	R:R:F262	4.29	No	No	0	5	5
144	R:R:F261	R:R:F284	4.29	No	Yes	0	5	3
145	R:R:F261	R:R:I291	6.28	No	No	0	5	6
146	R:R:H264	R:R:M281	15.76	Yes	No	0	4	3
147	R:R:F284	R:R:H264	14.71	Yes	Yes	1	3	4
148	R:R:H264	R:R:Y287	3.27	Yes	Yes	0	4	5
149	R:R:C271	R:R:F267	4.19	No	Yes	7	5	4
150	R:R:C277	R:R:F267	9.78	No	Yes	7	6	4
151	R:R:F267	R:R:F280	6.43	Yes	No	0	4	2
152	R:R:C271	R:R:C277	7.28	No	No	7	5	6
153	R:R:P272	R:R:Q273	12.63	No	No	0	3	1
154	R:R:N274	R:R:P275	6.52	No	No	0	4	4
155	R:R:N274	R:R:Y276	4.65	No	No	0	4	3
156	R:R:C277	R:R:N274	6.3	No	No	0	6	4
157	R:R:F280	R:R:Y287	12.38	No	Yes	0	2	5
158	R:R:H283	R:R:Y287	5.44	No	Yes	0	4	5
159	R:R:F284	R:R:L288	4.87	Yes	No	0	3	4
160	R:R:D298	R:R:N294	12.12	No	No	0	9	9
161	R:R:I297	R:R:I301	4.42	No	No	0	7	9
162	R:R:I301	R:R:Y302	4.84	No	Yes	0	9	9
163	R:R:A303	R:R:L309	3.15	Yes	Yes	0	8	8
164	R:R:L309	R:R:S306	3	Yes	No	0	8	7
165	R:R:Q307	R:R:R310	4.67	No	No	0	4	8
166	R:R:F313	R:R:I317	3.77	No	No	0	6	5
167	R:R:I245	R:R:I249	2.94	No	No	0	7	7
168	R:R:I137	R:R:M204	2.92	No	No	0	6	6
169	R:R:I251	R:R:M208	2.92	No	No	0	7	8
170	R:R:I69	R:R:L309	2.85	No	Yes	0	8	8
171	R:R:I198	R:R:L265	2.85	No	No	0	5	5
172	R:R:L59	R:R:M91	2.83	No	No	0	6	7
173	R:R:L141	R:R:M208	2.83	No	No	0	7	8
174	R:R:E49	R:R:T53	2.82	No	No	0	3	3
175	R:R:L197	R:R:L265	2.77	No	No	0	5	5
176	R:R:A259	R:R:F201	2.77	No	Yes	0	4	6
177	R:R:F51	R:R:V46	2.62	Yes	No	0	6	5
178	R:R:F81	R:R:V166	2.62	No	No	0	4	7
179	R:R:A89	R:R:W174	2.59	No	Yes	0	8	9
180	R:R:H283	R:R:L44	2.57	No	No	0	4	2
181	R:R:S77	R:R:Y80	2.54	No	Yes	0	7	8
182	R:R:F149	R:R:M161	2.49	No	No	0	6	7
183	R:R:F267	R:R:L263	2.44	Yes	No	0	4	5
184	R:R:F313	R:R:L304	2.44	No	No	0	6	6
185	R:R:L217	R:R:R220	2.43	No	No	0	4	5
186	L:L:R7	R:R:N123	2.41	Yes	No	0	0	5
187	R:R:M215	R:R:Y212	2.39	No	Yes	0	9	9
188	R:R:L183	R:R:Y187	2.34	No	No	0	5	4
189	R:R:R305	R:R:R310	2.13	No	No	0	8	8
190	R:R:C130	R:R:G181	1.96	No	No	0	4	6
191	R:R:C271	R:R:P272	1.88	No	No	0	5	3
192	R:R:G55	R:R:S94	1.86	No	No	0	6	8
193	R:R:G98	R:R:T101	1.82	No	Yes	0	6	6
194	R:R:C138	R:R:C177	1.82	No	Yes	5	5	7
195	R:R:P78	R:R:S77	1.78	No	No	0	6	7
196	R:R:P299	R:R:V65	1.77	No	No	0	9	9
197	R:R:P48	R:R:T101	1.75	No	Yes	0	5	6
198	R:R:A192	R:R:S190	1.71	No	No	0	5	4
199	R:R:C84	R:R:I69	1.64	No	No	0	5	8
200	R:R:C138	R:R:I173	1.64	No	No	5	5	5
201	R:R:C177	R:R:I173	1.64	Yes	No	5	7	5
202	R:R:C293	R:R:I289	1.64	No	No	0	4	5
203	R:R:A303	R:R:I83	1.62	Yes	No	0	8	8
204	R:R:S99	R:R:V95	1.62	No	No	0	6	5
205	R:R:S116	R:R:V119	1.62	No	No	0	3	3
206	R:R:A209	R:R:I251	1.62	No	No	0	5	7
207	R:R:V46	R:R:V50	1.6	No	No	0	5	4
208	R:R:T53	R:R:V50	1.59	No	No	0	3	4
209	R:R:C293	R:R:L54	1.59	No	No	0	4	6
210	R:R:A303	R:R:L304	1.58	Yes	No	0	8	6
211	R:R:I129	R:R:S96	1.55	No	No	0	5	6
212	R:R:I269	R:R:S270	1.55	No	No	0	4	4
213	R:R:I63	R:R:V67	1.54	No	No	0	4	4
214	R:R:I316	R:R:V67	1.54	No	No	0	7	4
215	R:R:I121	R:R:V103	1.54	No	No	0	4	3
216	R:R:I251	R:R:V255	1.54	No	No	0	7	5
217	R:R:I121	R:R:T118	1.52	No	No	0	4	6
218	R:R:I182	R:R:T178	1.52	No	No	0	3	3
219	R:R:M204	R:R:T203	1.51	No	No	0	6	4
220	R:R:K164	R:R:T162	1.5	No	No	0	4	8
221	R:R:L59	R:R:V95	1.49	No	No	0	6	5
222	R:R:L183	R:R:V179	1.49	No	No	0	5	3
223	R:R:L217	R:R:V213	1.49	No	No	0	4	3
224	R:R:L247	R:R:V213	1.49	No	No	0	8	3
225	R:R:L229	R:R:V228	1.49	No	No	0	4	4
226	R:R:N123	R:R:V119	1.48	No	No	0	5	3
227	R:R:I296	R:R:I57	1.47	No	No	0	6	5
228	R:R:L106	R:R:T105	1.47	No	No	0	4	4
229	R:R:I169	R:R:I173	1.47	No	No	0	5	5
230	R:R:I195	R:R:I269	1.47	No	No	0	4	4
231	R:R:I249	R:R:I301	1.47	No	No	0	7	9
232	R:R:I160	R:R:M161	1.46	No	No	0	5	7
233	R:R:I245	R:R:M241	1.46	No	No	0	7	4
234	R:R:I168	R:R:K164	1.45	No	No	0	3	4
235	R:R:F45	R:R:P48	1.44	No	No	0	3	5
236	R:R:L221	R:R:M218	1.41	No	No	0	5	5
237	R:R:H283	R:R:S282	1.39	No	No	0	4	1
238	R:R:L106	R:R:L107	1.38	No	No	0	4	4
239	R:R:L300	R:R:L304	1.38	No	No	0	6	6
240	R:R:K311	R:R:Q307	1.36	No	No	0	4	4
241	R:R:L155	R:R:Q156	1.33	No	No	0	8	6
242	R:R:H222	R:R:M218	1.31	No	No	0	7	5
243	R:R:Q156	R:R:Y153	1.13	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?6	8.482	5	2	0
2	L:L:R7	6.212	5	2	0
3	L:L:?9	8.194	5	1	0
4	R:R:F51	7.45	5	4	6
5	R:R:N62	4.54	4	0	9
6	R:R:Y80	8.755	4	0	8
7	R:R:D90	5.69	4	0	9
8	R:R:T101	4.55	4	4	6
9	R:R:D126	8.6775	4	2	4
10	R:R:Y148	8.945	4	6	8
11	R:R:F152	11.1875	4	6	6
12	R:R:Y157	7.3375	4	0	9
13	R:R:W174	4.7475	4	0	9
14	R:R:C177	2.56	4	5	7
15	R:R:F184	4.978	5	0	4
16	R:R:F201	8.874	5	3	6
17	R:R:Y212	3.934	5	0	9
18	R:R:W258	5.73286	7	3	7
19	R:R:H264	9.5225	4	1	4
20	R:R:F267	5.71	4	7	4
21	R:R:F284	7.946	5	1	3
22	R:R:Y287	6.315	4	0	5
23	R:R:Y302	4.54	4	0	9
24	R:R:A303	2.435	4	0	8
25	R:R:L309	3.2875	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F284	R:R:L288	77.8237	4.87	Yes	No	0	3	4
2	L:L:?6	R:R:L288	76.7744	3.52	Yes	No	0	0	4
3	R:R:F51	R:R:M292	31.298	3.73	Yes	No	0	6	5
4	R:R:M292	R:R:N97	32.8348	5.61	No	No	0	5	6
5	R:R:I129	R:R:N97	34.4047	4.25	No	No	0	5	6
6	L:L:?6	R:R:I129	39.0151	15.72	Yes	No	0	0	5
7	L:L:R7	R:R:S188	31.5707	9.22	Yes	No	0	0	4
8	L:L:W8	R:R:S188	30.0504	8.65	No	No	0	0	4
9	L:L:W8	R:R:I194	28.4144	5.87	No	No	0	0	4
10	R:R:F284	R:R:H264	36.9908	14.71	Yes	Yes	1	3	4
11	R:R:H264	R:R:Y287	34.6939	3.27	Yes	Yes	0	4	5
12	R:R:F280	R:R:Y287	21.6062	12.38	No	Yes	0	2	5
13	R:R:F267	R:R:F280	19.8959	6.43	Yes	No	0	4	2
14	R:R:C277	R:R:F267	10.9477	9.78	No	Yes	7	6	4
15	R:R:F51	R:R:V46	11.0468	2.62	Yes	No	0	6	5
16	R:R:F261	R:R:F284	98.9094	4.29	No	Yes	0	5	3
17	R:R:F261	R:R:F262	100	4.29	No	No	0	5	5
18	R:R:F262	R:R:W258	97.0421	3.01	No	Yes	3	5	7
19	R:R:S136	R:R:W258	48.0955	3.71	No	Yes	0	9	7
20	R:R:D90	R:R:S136	48.3269	4.42	Yes	No	0	9	9
21	R:R:D90	R:R:N62	75.8159	4.04	Yes	Yes	0	9	9
22	R:R:N62	R:R:P299	70.1892	6.52	Yes	No	0	9	9
23	R:R:P299	R:R:V65	65.7936	1.77	No	No	0	9	9
24	R:R:A303	R:R:V65	64.6534	3.39	Yes	No	0	8	9
25	R:R:A303	R:R:L309	56.2092	3.15	Yes	Yes	0	8	8
26	R:R:L309	R:R:L75	36.5942	4.15	Yes	No	0	8	9
27	R:R:L75	R:R:N72	21.9037	5.49	No	No	0	9	7
28	R:R:N72	R:R:T312	17.0949	10.24	No	No	0	7	7
29	R:R:K71	R:R:T312	13.8065	3	No	No	0	5	7
30	R:R:I316	R:R:K71	12.1375	5.82	No	No	0	7	5
31	R:R:I316	R:R:V67	10.452	1.54	No	No	0	7	4
32	R:R:L75	R:R:Y80	15.4259	14.07	No	Yes	0	9	8
33	R:R:S77	R:R:Y80	23.1843	2.54	No	Yes	0	7	8
34	R:R:P78	R:R:S77	19.9207	1.78	No	No	0	6	7
35	R:R:P78	R:R:V166	16.6405	3.53	No	No	0	6	7
36	R:R:F81	R:R:V166	10.0306	2.62	No	No	0	4	7
37	R:R:L309	R:R:S306	15.9712	3	Yes	No	0	8	7
38	R:R:S306	R:R:Y80	14.4592	7.63	No	Yes	0	7	8
39	R:R:N294	R:R:W258	55.9944	12.43	No	Yes	0	9	7
40	R:R:D298	R:R:N294	56.4736	12.12	No	No	0	9	9
41	R:R:D298	R:R:L86	88.4491	4.07	No	No	0	9	9
42	R:R:L86	R:R:S139	41.6591	3	No	No	0	9	8
43	R:R:S139	R:R:S85	40.1884	3.26	No	No	0	8	9
44	R:R:I170	R:R:S85	24.5724	6.19	No	No	0	7	9
45	R:R:F82	R:R:I170	22.9199	3.77	No	No	0	8	7
46	R:R:D146	R:R:F82	19.5654	8.36	No	No	0	9	8
47	R:R:S85	R:R:W174	16.2026	4.94	No	Yes	0	9	9
48	R:R:L140	R:R:L86	62.9431	4.15	No	No	0	8	9
49	R:R:I194	R:R:V193	21.7054	3.07	No	No	0	4	5
50	R:R:F184	R:R:V193	19.9868	5.24	Yes	No	0	4	5
51	R:R:A135	R:R:W174	10.9477	7.78	No	Yes	0	7	9
52	R:R:L140	R:R:Y302	61.7368	3.52	No	Yes	0	8	9
53	R:R:R147	R:R:Y302	51.4418	6.17	No	Yes	0	9	9
54	R:R:R147	R:R:Y212	50.1363	6.17	No	Yes	0	9	9
55	R:R:M208	R:R:Y212	10.9477	3.59	No	Yes	0	8	9
56	R:R:D146	R:R:Y157	17.9212	5.75	No	Yes	0	9	9
57	R:R:M161	R:R:Y157	12.7159	9.58	No	Yes	0	7	9
58	R:R:M215	R:R:Y212	22.9282	2.39	No	Yes	0	9	9
59	R:R:M215	R:R:Y148	12.4019	3.59	No	Yes	0	9	8
60	R:R:F152	R:R:M218	10.7081	6.22	Yes	No	0	6	5
61	R:R:L250	R:R:Y212	17.8799	3.52	No	Yes	0	8	9
62	R:R:L250	R:R:T246	16.1613	2.95	No	No	0	8	9
63	R:R:G243	R:R:T246	14.4262	3.64	No	No	0	8	9
64	R:R:G243	R:R:N240	12.6745	5.09	No	No	0	8	7
65	R:R:I301	R:R:Y302	10.9312	4.84	No	Yes	0	9	9
66	L:L:?6	L:L:R7	39.7753	7.21	Yes	Yes	2	0	0
67	R:R:D298	R:R:D90	34.6774	3.99	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R2	R:R:D122	4.76	0	No	No	0	8	0	1
L:L:?4	R:R:I104	5.81	0	No	No	0	4	0	1
L:L:H5	R:R:F51	18.1	4	No	Yes	0	6	0	1
L:L:H5	R:R:T101	6.85	4	No	Yes	0	6	0	1
L:L:?6	R:R:E100	5.61	2	Yes	No	0	5	0	1
L:L:?6	R:R:D126	10.35	2	Yes	Yes	0	4	0	1
L:L:?6	R:R:I129	15.72	2	Yes	No	0	5	0	1
L:L:?6	R:R:L288	3.52	2	Yes	No	0	4	0	1
L:L:R7	R:R:D126	5.96	2	Yes	Yes	0	4	0	1
L:L:R7	R:R:I185	6.26	2	Yes	No	0	5	0	1
L:L:R7	R:R:S188	9.22	2	Yes	No	0	4	0	1
L:L:W8	R:R:S188	8.65	0	No	No	0	4	0	1
L:L:W8	R:R:I194	5.87	0	No	No	0	4	0	1
L:L:?9	R:R:Q43	6	1	Yes	No	0	3	0	1
L:L:?9	R:R:H264	4.35	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:Y268	3.96	1	Yes	No	0	5	0	1
L:L:?9	R:R:F284	12.35	1	Yes	Yes	0	3	0	1
R:R:F284	R:R:Q43	3.51	1	Yes	No	3	3	1	1
R:R:F51	R:R:T101	7.78	4	Yes	Yes	6	6	1	1
R:R:F51	R:R:I289	5.02	4	Yes	No	6	5	1	2
R:R:F51	R:R:M292	3.73	4	Yes	No	6	5	1	2
R:R:I129	R:R:N97	4.25	0	No	No	5	6	1	2
R:R:M292	R:R:N97	5.61	0	No	No	5	6	2	2
R:R:E100	R:R:I125	6.83	2	No	No	5	5	1	2
R:R:D126	R:R:E100	9.09	2	Yes	No	4	5	1	1
R:R:D122	R:R:D126	9.31	0	No	Yes	8	4	1	1
R:R:I185	R:R:S127	10.84	0	No	No	5	5	1	2
R:R:I194	R:R:V193	3.07	0	No	No	4	5	1	2
R:R:I194	R:R:I269	8.83	0	No	No	4	4	1	2
R:R:F261	R:R:F284	4.29	0	No	Yes	5	3	2	1
R:R:H264	R:R:M281	15.76	1	Yes	No	4	3	1	2
R:R:F284	R:R:H264	14.71	1	Yes	Yes	3	4	1	1
R:R:H264	R:R:Y287	3.27	1	Yes	Yes	4	5	1	2
R:R:F284	R:R:L288	4.87	1	Yes	No	3	4	1	1
R:R:F51	R:R:V46	2.62	4	Yes	No	6	5	1	2
L:L:R7	R:R:N123	2.41	2	Yes	No	0	5	0	1
R:R:G98	R:R:T101	1.82	0	No	Yes	6	6	2	1
R:R:P48	R:R:T101	1.75	0	No	Yes	5	6	2	1
R:R:I129	R:R:S96	1.55	0	No	No	5	6	1	2
R:R:N123	R:R:V119	1.48	0	No	No	5	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7AUE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	237
Number of Links	243
Number of Hubs	25
Number of Links mediated by Hubs	99
Number of Communities	7
Number of Nodes involved in Communities	24
Number of Links involved in Communities	27

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	25214
Length Of Smallest Path	3
Average Path Length	14.9165
Length of Longest Path	34
Minimum Path Strength	1.23
Average Path Strength	5.30414
Maximum Path Strength	16.615
Minimum Path Correlation	0.7
Average Path Correlation	0.933095
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	50.826
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.0164
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	CY3
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	CY3
Name	Cysteinamide
Synonyms	2-amino-3-mercapto-propionamide L-Cysteinamide Cysteinamide
Identifier
Formula	C3 H8 N2 O S
Molecular Weight	120.173
SMILES
PubChem	6540253
Formal Charge	0
Total Atoms	15
Total Chiral Atoms	1
Total Bonds	14
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32245
Sequence	>7AUE_nogp_Chain_R C Y E Q L F V S P E V F V T L G V I S L L E N I L V I V A I A K N K N L H S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L N S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y A L Q Y H N I M T V K R V G I I I S C I W A A C T V S G I L F I I Y S D S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L P G N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C P Q N P Y C V C F M S H F N L Y L I L I M C N S I I D P L I Y A L R S Q E L R K T F K E I I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6W25	A	Peptide	Melanocortin	MC₄	Homo sapiens	SHU9119	Ca	-	2.75	2020-04-29	doi.org/10.1126/science.aaz8995
	7F53	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F53 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7PIU	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIU (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7AUE	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	chim(NtGi1L-Gs)/β1/γ2	2.97	2021-04-28	doi.org/10.1126/science.abf7958
	7AUE (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.97	2021-04-28	doi.org/10.1126/science.abf7958
	8WKY	A	Peptide	Melanocortin	MC₄	Homo sapiens	PG-934	-	-	2.9	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8WKZ	A	Peptide	Melanocortin	MC₄	Homo sapiens	SBL-MC-31	-	-	3.3	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8QJ2	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-	Gs	3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	8QJ2 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-		3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	9K3K	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3K (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-		3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7AUE_nogp.zip

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