Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?6 8.482520
2L:L:R7 6.212520
3L:L:?9 8.194510
4R:R:F51 7.45546
5R:R:N62 4.54409
6R:R:Y80 8.755408
7R:R:D90 5.69409
8R:R:T101 4.55446
9R:R:D126 8.6775424
10R:R:Y148 8.945468
11R:R:F152 11.1875466
12R:R:Y157 7.3375409
13R:R:W174 4.7475409
14R:R:C177 2.56457
15R:R:F184 4.978504
16R:R:F201 8.874536
17R:R:Y212 3.934509
18R:R:W258 5.73286737
19R:R:H264 9.5225414
20R:R:F267 5.71474
21R:R:F284 7.946513
22R:R:Y287 6.315405
23R:R:Y302 4.54409
24R:R:A303 2.435408
25R:R:L309 3.2875408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F284 R:R:L288 77.82374.87YesNo034
2L:L:?6 R:R:L288 76.77443.52YesNo004
3R:R:F51 R:R:M292 31.2983.73YesNo065
4R:R:M292 R:R:N97 32.83485.61NoNo056
5R:R:I129 R:R:N97 34.40474.25NoNo056
6L:L:?6 R:R:I129 39.015115.72YesNo005
7L:L:R7 R:R:S188 31.57079.22YesNo004
8L:L:W8 R:R:S188 30.05048.65NoNo004
9L:L:W8 R:R:I194 28.41445.87NoNo004
10R:R:F284 R:R:H264 36.990814.71YesYes134
11R:R:H264 R:R:Y287 34.69393.27YesYes045
12R:R:F280 R:R:Y287 21.606212.38NoYes025
13R:R:F267 R:R:F280 19.89596.43YesNo042
14R:R:C277 R:R:F267 10.94779.78NoYes764
15R:R:F51 R:R:V46 11.04682.62YesNo065
16R:R:F261 R:R:F284 98.90944.29NoYes053
17R:R:F261 R:R:F262 1004.29NoNo055
18R:R:F262 R:R:W258 97.04213.01NoYes357
19R:R:S136 R:R:W258 48.09553.71NoYes097
20R:R:D90 R:R:S136 48.32694.42YesNo099
21R:R:D90 R:R:N62 75.81594.04YesYes099
22R:R:N62 R:R:P299 70.18926.52YesNo099
23R:R:P299 R:R:V65 65.79361.77NoNo099
24R:R:A303 R:R:V65 64.65343.39YesNo089
25R:R:A303 R:R:L309 56.20923.15YesYes088
26R:R:L309 R:R:L75 36.59424.15YesNo089
27R:R:L75 R:R:N72 21.90375.49NoNo097
28R:R:N72 R:R:T312 17.094910.24NoNo077
29R:R:K71 R:R:T312 13.80653NoNo057
30R:R:I316 R:R:K71 12.13755.82NoNo075
31R:R:I316 R:R:V67 10.4521.54NoNo074
32R:R:L75 R:R:Y80 15.425914.07NoYes098
33R:R:S77 R:R:Y80 23.18432.54NoYes078
34R:R:P78 R:R:S77 19.92071.78NoNo067
35R:R:P78 R:R:V166 16.64053.53NoNo067
36R:R:F81 R:R:V166 10.03062.62NoNo047
37R:R:L309 R:R:S306 15.97123YesNo087
38R:R:S306 R:R:Y80 14.45927.63NoYes078
39R:R:N294 R:R:W258 55.994412.43NoYes097
40R:R:D298 R:R:N294 56.473612.12NoNo099
41R:R:D298 R:R:L86 88.44914.07NoNo099
42R:R:L86 R:R:S139 41.65913NoNo098
43R:R:S139 R:R:S85 40.18843.26NoNo089
44R:R:I170 R:R:S85 24.57246.19NoNo079
45R:R:F82 R:R:I170 22.91993.77NoNo087
46R:R:D146 R:R:F82 19.56548.36NoNo098
47R:R:S85 R:R:W174 16.20264.94NoYes099
48R:R:L140 R:R:L86 62.94314.15NoNo089
49R:R:I194 R:R:V193 21.70543.07NoNo045
50R:R:F184 R:R:V193 19.98685.24YesNo045
51R:R:A135 R:R:W174 10.94777.78NoYes079
52R:R:L140 R:R:Y302 61.73683.52NoYes089
53R:R:R147 R:R:Y302 51.44186.17NoYes099
54R:R:R147 R:R:Y212 50.13636.17NoYes099
55R:R:M208 R:R:Y212 10.94773.59NoYes089
56R:R:D146 R:R:Y157 17.92125.75NoYes099
57R:R:M161 R:R:Y157 12.71599.58NoYes079
58R:R:M215 R:R:Y212 22.92822.39NoYes099
59R:R:M215 R:R:Y148 12.40193.59NoYes098
60R:R:F152 R:R:M218 10.70816.22YesNo065
61R:R:L250 R:R:Y212 17.87993.52NoYes089
62R:R:L250 R:R:T246 16.16132.95NoNo089
63R:R:G243 R:R:T246 14.42623.64NoNo089
64R:R:G243 R:R:N240 12.67455.09NoNo087
65R:R:I301 R:R:Y302 10.93124.84NoYes099
66L:L:?6 L:L:R7 39.77537.21YesYes200
67R:R:D298 R:R:D90 34.67743.99NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R2 R:R:D122 4.76 0 No No 0 8 0 1
L:L:?4 R:R:I104 5.81 0 No No 0 4 0 1
L:L:H5 R:R:F51 18.1 4 No Yes 0 6 0 1
L:L:H5 R:R:T101 6.85 4 No Yes 0 6 0 1
L:L:?6 R:R:E100 5.61 2 Yes No 0 5 0 1
L:L:?6 R:R:D126 10.35 2 Yes Yes 0 4 0 1
L:L:?6 R:R:I129 15.72 2 Yes No 0 5 0 1
L:L:?6 R:R:L288 3.52 2 Yes No 0 4 0 1
L:L:R7 R:R:D126 5.96 2 Yes Yes 0 4 0 1
L:L:R7 R:R:I185 6.26 2 Yes No 0 5 0 1
L:L:R7 R:R:S188 9.22 2 Yes No 0 4 0 1
L:L:W8 R:R:S188 8.65 0 No No 0 4 0 1
L:L:W8 R:R:I194 5.87 0 No No 0 4 0 1
L:L:?9 R:R:Q43 6 1 Yes No 0 3 0 1
L:L:?9 R:R:H264 4.35 1 Yes Yes 0 4 0 1
L:L:?9 R:R:Y268 3.96 1 Yes No 0 5 0 1
L:L:?9 R:R:F284 12.35 1 Yes Yes 0 3 0 1
R:R:F284 R:R:Q43 3.51 1 Yes No 3 3 1 1
R:R:F51 R:R:T101 7.78 4 Yes Yes 6 6 1 1
R:R:F51 R:R:I289 5.02 4 Yes No 6 5 1 2
R:R:F51 R:R:M292 3.73 4 Yes No 6 5 1 2
R:R:I129 R:R:N97 4.25 0 No No 5 6 1 2
R:R:M292 R:R:N97 5.61 0 No No 5 6 2 2
R:R:E100 R:R:I125 6.83 2 No No 5 5 1 2
R:R:D126 R:R:E100 9.09 2 Yes No 4 5 1 1
R:R:D122 R:R:D126 9.31 0 No Yes 8 4 1 1
R:R:I185 R:R:S127 10.84 0 No No 5 5 1 2
R:R:I194 R:R:V193 3.07 0 No No 4 5 1 2
R:R:I194 R:R:I269 8.83 0 No No 4 4 1 2
R:R:F261 R:R:F284 4.29 0 No Yes 5 3 2 1
R:R:H264 R:R:M281 15.76 1 Yes No 4 3 1 2
R:R:F284 R:R:H264 14.71 1 Yes Yes 3 4 1 1
R:R:H264 R:R:Y287 3.27 1 Yes Yes 4 5 1 2
R:R:F284 R:R:L288 4.87 1 Yes No 3 4 1 1
R:R:F51 R:R:V46 2.62 4 Yes No 6 5 1 2
L:L:R7 R:R:N123 2.41 2 Yes No 0 5 0 1
R:R:G98 R:R:T101 1.82 0 No Yes 6 6 2 1
R:R:P48 R:R:T101 1.75 0 No Yes 5 6 2 1
R:R:I129 R:R:S96 1.55 0 No No 5 6 1 2
R:R:N123 R:R:V119 1.48 0 No No 5 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7AUE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.95
Number of Linked Nodes 237
Number of Links 243
Number of Hubs 25
Number of Links mediated by Hubs 99
Number of Communities 7
Number of Nodes involved in Communities 24
Number of Links involved in Communities 27
Path Summary
Number Of Nodes in MetaPath 68
Number Of Links MetaPath 67
Number of Shortest Paths 25214
Length Of Smallest Path 3
Average Path Length 14.9165
Length of Longest Path 34
Minimum Path Strength 1.23
Average Path Strength 5.30414
Maximum Path Strength 16.615
Minimum Path Correlation 0.7
Average Path Correlation 0.933095
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 50.826
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 33.0164
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • neuropeptide binding   • peptide binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • melanocortin receptor activity   • ubiquitin protein ligase binding   • protein binding   • ubiquitin-like protein ligase binding   • enzyme binding   • melanocyte-stimulating hormone receptor activity   • corticotropin receptor activity   • neuropeptide receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of behavior   • behavior
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of behavior   • behavior   • regulation of eating behavior   • multicellular organismal process   • eating behavior   • feeding behavior   • regulation of feeding behavior   • regulation of multicellular organismal process   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to insulin   • response to oxygen-containing compound   • response to nitrogen compound   • homeostatic process   • positive regulation of biological process   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • positive regulation of multicellular organismal process   • positive regulation of bone resorption   • response to melanocyte-stimulating hormone   • negative regulation of feeding behavior   • negative regulation of behavior   • negative regulation of eating behavior   • negative regulation of biological process   • negative regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • secretion by cell   • signal release   • regulation of biological quality   • intracellular protein localization   • secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • cell-cell signaling   • export from cell   • protein secretion   • establishment of localization   • peptide transport   • protein transport   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • response to nutrient levels   • response to food   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • intracellular anatomical structure   • cytoplasm   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • system process   • nervous system process   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of cell communication   • regulation of localization   • positive regulation of establishment of protein localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • positive regulation of peptide hormone secretion   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • positive regulation of secretion by cell   • positive regulation of protein transport   • regulation of secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • regulation of insulin secretion   • regulation of insulin secretion involved in cellular response to glucose stimulus   • regulation of cell communication   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • serotonin receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • adenylate cyclase-activating dopamine receptor signaling pathway   • G protein-coupled dopamine receptor signaling pathway   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDAL
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeDAL
NameD-Alanine
SynonymsD-Alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0

CodeDPN
PDB ResiduesL:L:?6
Environment DetailsOpen EMBL-EBI Page
CodeDPN
NameD-Phenylalanine
SynonymsD-Phenylalanine
Identifier
FormulaC9 H11 N O2
Molecular Weight165.189
SMILES
PubChem71567
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6

CodeCY3
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeCY3
NameCysteinamide
Synonyms
  • Cysteinamide
  • 2-amino-3-mercapto-propionamide
  • L-Cysteinamide
Identifier
FormulaC3 H8 N2 O S
Molecular Weight120.173
SMILES
PubChem6540253
Formal Charge0
Total Atoms15
Total Chiral Atoms1
Total Bonds14
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP32245
Sequence
>7AUE_nogp_Chain_R
CYEQLFVSP EVFVTLGVI SLLENILVI VAIAKNKNL HSPMYFFIC 
SLAVADMLV SVSNGSETI VITLLNSFT VNIDNVIDS VICSSLLAS 
ICSLLSIAV DRYFTIFYA LQYHNIMTV KRVGIIISC IWAACTVSG 
ILFIIYSDS SAVIICLIT MFFTMLALM ASLYVHMFL MARLHIKRI 
AVLPGNMKG AITLTILIG VFVVCWAPF FLHLIFYIS CPQNPYCVC 
FMSHFNLYL ILIMCNSII DPLIYALRS QELRKTFKE II


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W25APeptideMelanocortinMC4Homo sapiensSHU9119Ca-2.752020-04-29doi.org/10.1126/science.aaz8995
7AUEAPeptideMelanocortinMC4Homo sapiensSetmelanotide-chim(NtGi1L-Gs)/β1/γ22.972021-04-28doi.org/10.1126/science.abf7958
7AUE (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.972021-04-28doi.org/10.1126/science.abf7958
7F53APeptideMelanocortinMC4Homo sapiensα-MSH-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F53 (No Gprot) APeptideMelanocortinMC4Homo sapiensα-MSH-32021-11-03doi.org/10.1038/s41422-021-00552-3
7F54APeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/β1/γ232021-11-03doi.org/10.1038/s41422-021-00552-3
7F54 (No Gprot) APeptideMelanocortinMC4Homo sapiensAfamelanotide-32021-11-03doi.org/10.1038/s41422-021-00552-3
7F55APeptideMelanocortinMC4Homo sapiensBremelanotide-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F55 (No Gprot) APeptideMelanocortinMC4Homo sapiensBremelanotide-3.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58APeptideMelanocortinMC4Homo sapiensTHIQ-Gs/β1/γ23.12021-11-03doi.org/10.1038/s41422-021-00552-3
7F58 (No Gprot) APeptideMelanocortinMC4Homo sapiensTHIQ-3.12021-11-03doi.org/10.1038/s41422-021-00552-3
7PIUAPeptideMelanocortinMC4Homo sapiensSetmelanotide-Gs/β1/γ22.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIU (No Gprot) APeptideMelanocortinMC4Homo sapiensSetmelanotide-2.582021-11-17doi.org/10.1038/s41422-021-00569-8
7PIVAPeptideMelanocortinMC4Homo sapiensAfamelanotide-Gs/β1/γ22.862021-11-17doi.org/10.1038/s41422-021-00569-8
7PIV (No Gprot) APeptideMelanocortinMC4Homo sapiensAfamelanotide-2.862021-11-17doi.org/10.1038/s41422-021-00569-8
8WKYAPeptideMelanocortinMC4Homo sapiensPG-934--2.92024-08-07doi.org/10.1021/acs.jmedchem.3c01822
8WKZAPeptideMelanocortinMC4Homo sapiensSBL-MC-31--3.32024-08-07doi.org/10.1021/acs.jmedchem.3c01822
8QJ2APeptideMelanocortinMC4Homo sapienspN162-Gs/β1/γ23.42024-09-25doi.org/10.1038/s41467-024-50827-7
8QJ2 (No Gprot) APeptideMelanocortinMC4Homo sapienspN162-3.42024-09-25doi.org/10.1038/s41467-024-50827-7
9K3KAPeptideMelanocortinMC4Homo sapiens--chim(NtGi1-Gs)/β1/γ23.122025-08-06doi.org/10.1016/j.str.2025.03.004
9K3K (No Gprot) APeptideMelanocortinMC4Homo sapiens--3.122025-08-06doi.org/10.1016/j.str.2025.03.004




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7AUE_nogp.zip



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