psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R1	R:R:D122	8.34	No	No	0	0	8
2	L:L:C2	L:L:C8	7.28	No	No	0	0	0
3	L:L:?3	L:L:H4	14.39	No	Yes	0	0	0
4	L:L:?3	R:R:I104	5.81	No	No	0	0	4
5	L:L:H4	R:R:F51	22.63	Yes	Yes	2	0	6
6	L:L:H4	R:R:T101	6.85	Yes	No	2	0	6
7	L:L:H4	R:R:N285	5.1	Yes	No	2	0	4
8	L:L:?5	L:L:R6	6.18	Yes	Yes	1	0	0
9	L:L:?5	R:R:E100	4.49	Yes	No	0	0	5
10	L:L:?5	R:R:D126	10.35	Yes	Yes	1	0	4
11	L:L:?5	R:R:I129	14.51	Yes	No	0	0	5
12	L:L:?5	R:R:F261	6.19	Yes	Yes	1	0	5
13	L:L:?5	R:R:F284	4.13	Yes	Yes	1	0	3
14	L:L:R6	L:L:W7	13.99	Yes	Yes	1	0	0
15	L:L:R6	R:R:N123	4.82	Yes	No	0	0	5
16	L:L:R6	R:R:D126	16.68	Yes	Yes	1	0	4
17	L:L:R6	R:R:I185	6.26	Yes	Yes	1	0	5
18	L:L:R6	R:R:S188	7.91	Yes	No	1	0	4
19	L:L:W7	R:R:S188	3.71	Yes	No	1	0	4
20	L:L:W7	R:R:I194	9.4	Yes	No	0	0	4
21	L:L:W7	R:R:Y268	9.65	Yes	No	0	0	5
22	L:L:C8	R:R:F284	8.38	No	Yes	0	0	3
23	R:R:C279	R:R:C40	7.28	No	No	5	4	2
24	R:R:N285	R:R:Q43	7.92	No	No	0	4	3
25	R:R:H283	R:R:L44	3.86	No	No	0	4	2
26	R:R:F45	R:R:P48	5.78	No	No	0	3	5
27	R:R:V46	R:R:V50	4.81	No	No	0	5	4
28	R:R:F51	R:R:V46	6.55	Yes	No	2	6	5
29	R:R:I289	R:R:V46	6.14	No	No	2	5	5
30	R:R:S47	R:R:V50	4.85	No	No	0	4	4
31	R:R:F51	R:R:T101	9.08	Yes	No	2	6	6
32	R:R:F51	R:R:N285	3.62	Yes	No	2	6	4
33	R:R:F51	R:R:I289	3.77	Yes	No	2	6	5
34	R:R:I296	R:R:L54	4.28	No	No	0	6	6
35	R:R:N62	R:R:S58	4.47	Yes	Yes	0	9	8
36	R:R:S58	R:R:S94	6.52	Yes	No	0	8	8
37	R:R:S295	R:R:S58	4.89	No	Yes	0	9	8
38	R:R:I296	R:R:S58	4.64	No	Yes	0	6	8
39	R:R:I63	R:R:L59	4.28	No	No	0	4	6
40	R:R:L59	R:R:V95	5.96	No	No	0	6	5
41	R:R:E61	R:R:P299	11	No	No	0	8	9
42	R:R:E61	R:R:L300	5.3	No	No	0	8	6
43	R:R:D90	R:R:N62	14.81	No	Yes	0	9	9
44	R:R:M91	R:R:N62	5.61	No	Yes	0	7	9
45	R:R:N62	R:R:P299	4.89	Yes	No	0	9	9
46	R:R:F313	R:R:L64	9.74	No	No	0	6	7
47	R:R:C84	R:R:I66	4.91	No	No	0	5	7
48	R:R:C84	R:R:I69	4.91	No	No	0	5	8
49	R:R:N72	R:R:N74	6.81	No	No	0	7	6
50	R:R:L75	R:R:N72	13.73	Yes	No	0	9	7
51	R:R:N72	R:R:T312	5.85	No	No	0	7	7
52	R:R:H76	R:R:K73	17.03	No	No	0	8	5
53	R:R:L75	R:R:Y80	9.38	Yes	Yes	0	9	8
54	R:R:E308	R:R:L75	5.3	No	Yes	0	6	9
55	R:R:L309	R:R:L75	4.15	No	Yes	0	8	9
56	R:R:F81	R:R:H76	5.66	No	No	0	4	8
57	R:R:S77	R:R:Y80	5.09	No	Yes	0	7	8
58	R:R:P78	R:R:Y157	5.56	No	Yes	0	6	9
59	R:R:M79	R:R:Y80	4.79	Yes	Yes	0	8	8
60	R:R:I83	R:R:M79	4.37	No	Yes	0	8	8
61	R:R:D146	R:R:M79	4.16	Yes	Yes	0	9	8
62	R:R:M79	R:R:R147	7.44	Yes	Yes	0	8	9
63	R:R:S306	R:R:Y80	7.63	No	Yes	0	7	8
64	R:R:F81	R:R:V166	3.93	No	No	0	4	7
65	R:R:F82	R:R:S142	6.61	Yes	No	0	8	7
66	R:R:D146	R:R:F82	8.36	Yes	Yes	0	9	8
67	R:R:F82	R:R:V166	5.24	Yes	No	0	8	7
68	R:R:F82	R:R:I170	5.02	Yes	No	0	8	7
69	R:R:S139	R:R:S85	4.89	No	No	0	8	9
70	R:R:I170	R:R:S85	4.64	No	No	0	7	9
71	R:R:S85	R:R:W174	4.94	No	Yes	0	9	9
72	R:R:L86	R:R:S139	4.5	Yes	No	0	9	8
73	R:R:L140	R:R:L86	6.92	No	Yes	0	8	9
74	R:R:I143	R:R:L86	4.28	No	Yes	0	9	9
75	R:R:D298	R:R:L86	6.79	No	Yes	0	9	9
76	R:R:V88	R:R:W174	3.68	No	Yes	0	6	9
77	R:R:D90	R:R:S295	8.83	No	No	0	9	9
78	R:R:D298	R:R:D90	6.65	No	No	0	9	9
79	R:R:L92	R:R:S132	6.01	No	No	0	6	6
80	R:R:S132	R:R:V93	6.46	No	No	0	6	8
81	R:R:S96	R:R:V128	4.85	No	No	0	6	4
82	R:R:I129	R:R:S96	4.64	No	No	0	5	6
83	R:R:I129	R:R:N97	11.33	No	No	0	5	6
84	R:R:M292	R:R:N97	4.21	No	No	0	5	6
85	R:R:E100	R:R:I125	4.1	No	No	0	5	5
86	R:R:L107	R:R:T118	4.42	No	No	0	4	6
87	R:R:N123	R:R:V119	5.91	No	No	0	5	3
88	R:R:D122	R:R:D126	3.99	No	Yes	0	8	4
89	R:R:D126	R:R:I185	4.2	Yes	Yes	1	4	5
90	R:R:I185	R:R:S127	6.19	Yes	No	0	5	5
91	R:R:C130	R:R:G181	3.92	No	No	0	4	6
92	R:R:C130	R:R:F184	4.19	No	Yes	0	4	4
93	R:R:C130	R:R:I185	4.91	No	Yes	0	4	5
94	R:R:L133	R:R:W258	5.69	No	Yes	0	5	7
95	R:R:F184	R:R:L134	3.65	Yes	No	0	4	5
96	R:R:A135	R:R:W174	7.78	No	Yes	0	7	9
97	R:R:A135	R:R:C177	3.61	No	No	0	7	7
98	R:R:S136	R:R:W258	4.94	No	Yes	0	9	7
99	R:R:I137	R:R:W258	10.57	No	Yes	0	6	7
100	R:R:C138	R:R:C177	3.64	No	No	0	5	7
101	R:R:L140	R:R:Y302	4.69	No	Yes	0	8	9
102	R:R:L141	R:R:M204	7.07	No	No	0	7	6
103	R:R:I173	R:R:S142	4.64	No	No	0	5	7
104	R:R:I143	R:R:R147	3.76	No	Yes	3	9	9
105	R:R:I143	R:R:Y302	6.04	No	Yes	3	9	9
106	R:R:A144	R:R:Y212	5.34	No	Yes	0	9	9
107	R:R:D146	R:R:Y157	6.9	Yes	Yes	6	9	9
108	R:R:D146	R:R:M161	4.16	Yes	No	6	9	7
109	R:R:R147	R:R:Y212	8.23	Yes	Yes	3	9	9
110	R:R:R147	R:R:Y302	4.12	Yes	Yes	3	9	9
111	R:R:F152	R:R:Y148	22.69	Yes	Yes	7	6	8
112	R:R:L211	R:R:Y148	8.21	No	Yes	0	7	8
113	R:R:H214	R:R:Y148	9.8	No	Yes	7	4	8
114	R:R:F149	R:R:Y153	8.25	No	No	0	6	6
115	R:R:F149	R:R:M161	3.73	No	No	0	6	7
116	R:R:T150	R:R:Y157	9.99	No	Yes	0	8	9
117	R:R:F152	R:R:I151	8.79	Yes	No	0	6	8
118	R:R:F152	R:R:H214	19.23	Yes	No	7	6	4
119	R:R:F152	R:R:M218	9.95	Yes	No	0	6	5
120	R:R:I160	R:R:Y153	3.63	No	No	0	5	6
121	R:R:H158	R:R:Y157	8.71	No	Yes	0	6	9
122	R:R:M161	R:R:Y157	10.78	No	Yes	6	7	9
123	R:R:R165	R:R:T162	5.17	No	No	0	6	8
124	R:R:I168	R:R:K164	4.36	No	No	0	3	4
125	R:R:F184	R:R:S180	10.57	Yes	No	0	4	4
126	R:R:F184	R:R:V193	7.87	Yes	No	0	4	5
127	R:R:F184	R:R:L197	8.53	Yes	No	0	4	5
128	R:R:F184	R:R:M200	3.73	Yes	No	0	4	4
129	R:R:I186	R:R:Y187	7.25	No	No	0	4	4
130	R:R:I194	R:R:L265	5.71	No	Yes	0	4	5
131	R:R:I194	R:R:I269	8.83	No	No	0	4	4
132	R:R:I198	R:R:I266	5.89	No	No	0	5	5
133	R:R:F201	R:R:F202	9.65	Yes	No	0	6	4
134	R:R:F201	R:R:L205	3.65	Yes	No	1	6	6
135	R:R:F201	R:R:F254	4.29	Yes	Yes	1	6	8
136	R:R:F201	R:R:W258	4.01	Yes	Yes	1	6	7
137	R:R:F201	R:R:F262	30.01	Yes	Yes	1	6	5
138	R:R:F254	R:R:L205	6.09	Yes	No	1	8	6
139	R:R:M208	R:R:Y212	4.79	No	Yes	0	8	9
140	R:R:F254	R:R:M208	6.22	Yes	No	0	8	8
141	R:R:L250	R:R:Y212	4.69	No	Yes	3	8	9
142	R:R:Y212	R:R:Y302	3.97	Yes	Yes	3	9	9
143	R:R:F216	R:R:N240	3.62	Yes	No	0	6	7
144	R:R:F216	R:R:L247	3.65	Yes	Yes	0	6	8
145	R:R:H222	R:R:M218	5.25	No	No	0	7	5
146	R:R:K224	R:R:R220	6.19	No	No	0	5	5
147	R:R:N240	R:R:R220	7.23	No	No	0	7	5
148	R:R:L250	R:R:Y302	4.69	No	Yes	3	8	9
149	R:R:F254	R:R:W258	9.02	Yes	Yes	1	8	7
150	R:R:C257	R:R:N294	7.87	No	No	0	8	9
151	R:R:F262	R:R:W258	4.01	Yes	Yes	1	5	7
152	R:R:I291	R:R:W258	7.05	No	Yes	0	6	7
153	R:R:N294	R:R:W258	12.43	No	Yes	0	9	7
154	R:R:P260	R:R:Y287	5.56	No	Yes	0	9	5
155	R:R:F261	R:R:F262	7.5	Yes	Yes	1	5	5
156	R:R:F261	R:R:L265	6.09	Yes	Yes	1	5	5
157	R:R:F261	R:R:F284	4.29	Yes	Yes	1	5	3
158	R:R:F261	R:R:I291	3.77	Yes	No	0	5	6
159	R:R:F262	R:R:L265	3.65	Yes	Yes	1	5	5
160	R:R:H264	R:R:M281	9.19	No	No	0	4	3
161	R:R:F284	R:R:H264	15.84	Yes	No	0	3	4
162	R:R:H264	R:R:Y287	6.53	No	Yes	0	4	5
163	R:R:C271	R:R:F267	5.59	Yes	Yes	4	5	4
164	R:R:C277	R:R:F267	6.98	No	Yes	4	6	4
165	R:R:F267	R:R:F280	8.57	Yes	No	4	4	2
166	R:R:C271	R:R:C277	7.28	Yes	No	4	5	6
167	R:R:N274	R:R:P275	6.52	No	No	0	4	4
168	R:R:C277	R:R:N274	6.3	No	No	0	6	4
169	R:R:F280	R:R:Y287	17.54	No	Yes	0	2	5
170	R:R:H283	R:R:Y287	6.53	No	Yes	0	4	5
171	R:R:F284	R:R:L288	9.74	Yes	No	0	3	4
172	R:R:D298	R:R:N294	12.12	No	No	0	9	9
173	R:R:I301	R:R:Y302	4.84	No	Yes	0	9	9
174	R:R:F313	R:R:L304	7.31	No	No	0	6	6
175	R:R:L309	R:R:S306	6.01	No	No	0	8	7
176	R:R:E315	R:R:K311	8.1	No	No	0	3	4
177	R:R:M215	R:R:Y148	3.59	No	Yes	0	9	8
178	R:R:M215	R:R:Y212	3.59	No	Yes	0	9	9
179	R:R:L247	R:R:Y212	3.52	Yes	Yes	0	8	9
180	R:R:F284	R:R:Q43	3.51	Yes	No	0	3	3
181	R:R:A87	R:R:V65	3.39	No	No	0	9	9
182	R:R:A303	R:R:V65	3.39	No	No	0	8	9
183	R:R:Q156	R:R:Y153	3.38	No	No	0	6	6
184	R:R:A68	R:R:T312	3.36	No	No	0	7	7
185	R:R:L229	R:R:P230	3.28	No	No	0	4	2
186	R:R:L290	R:R:P260	3.28	No	No	0	7	9
187	R:R:A87	R:R:I66	3.25	No	No	0	9	7
188	R:R:C138	R:R:M204	3.24	No	No	0	5	6
189	R:R:S131	R:R:T178	3.2	No	No	0	4	3
190	R:R:A303	R:R:L309	3.15	No	No	0	8	8
191	R:R:I125	R:R:S99	3.1	No	No	0	5	6
192	R:R:I269	R:R:S191	3.1	No	No	0	4	4
193	R:R:I102	R:R:V52	3.07	No	No	0	6	4
194	R:R:I297	R:R:V253	3.07	No	No	0	7	6
195	R:R:F216	R:R:G243	3.01	Yes	No	0	6	8
196	R:R:L133	R:R:V93	2.98	No	No	0	5	8
197	R:R:L107	R:R:V103	2.98	No	No	0	4	3
198	R:R:L211	R:R:V145	2.98	No	No	0	7	7
199	R:R:L250	R:R:T246	2.95	No	No	0	8	9
200	R:R:I121	R:R:I125	2.94	No	No	0	4	5
201	R:R:I169	R:R:I173	2.94	No	No	0	5	5
202	R:R:I182	R:R:I186	2.94	No	No	0	3	4
203	R:R:I297	R:R:I301	2.94	No	No	0	7	9
204	R:R:I63	R:R:M91	2.92	No	No	0	4	7
205	R:R:I102	R:R:L106	2.85	No	No	0	6	4
206	R:R:I198	R:R:L265	2.85	No	Yes	0	5	5
207	R:R:I251	R:R:L247	2.85	No	Yes	0	7	8
208	R:R:C196	R:R:F184	2.79	No	Yes	0	5	4
209	R:R:H283	R:R:S282	2.79	No	No	0	4	1
210	R:R:L286	R:R:L44	2.77	No	No	0	2	2
211	R:R:A259	R:R:F201	2.77	No	Yes	0	4	6
212	R:R:L300	R:R:L304	2.77	No	No	0	6	6
213	R:R:L155	R:R:Q156	2.66	No	No	0	8	6
214	R:R:A89	R:R:W174	2.59	No	Yes	0	8	9
215	R:R:E308	R:R:Q307	2.55	No	No	0	6	4
216	R:R:F267	R:R:L263	2.44	Yes	No	4	4	5
217	R:R:F280	R:R:L263	2.44	No	No	4	2	5
218	R:R:Q307	R:R:R310	2.34	No	No	0	4	8
219	R:R:N274	R:R:Y276	2.33	No	No	0	4	3
220	R:R:C271	R:R:P272	1.88	Yes	No	0	5	3
221	R:R:G55	R:R:S94	1.86	No	No	0	6	8
222	R:R:G181	R:R:S131	1.86	No	No	0	6	4
223	R:R:P48	R:R:S47	1.78	No	No	0	5	4
224	R:R:P48	R:R:T105	1.75	No	No	0	5	4
225	R:R:C271	R:R:S270	1.72	Yes	No	0	5	4
226	R:R:C40	R:R:V278	1.71	No	No	5	2	1
227	R:R:A192	R:R:S190	1.71	No	No	0	5	4
228	R:R:C279	R:R:V278	1.71	No	No	5	4	1
229	R:R:A259	R:R:V255	1.7	No	No	0	4	5
230	R:R:C293	R:R:I289	1.64	No	No	0	4	5
231	R:R:C293	R:R:I297	1.64	No	No	0	4	7
232	R:R:T53	R:R:V52	1.59	No	No	0	3	4
233	R:R:T199	R:R:T203	1.57	No	No	0	4	4
234	R:R:I195	R:R:S191	1.55	No	No	0	4	4
235	R:R:I57	R:R:V56	1.54	No	No	0	5	4
236	R:R:I63	R:R:V67	1.54	No	No	0	4	4
237	R:R:I316	R:R:V67	1.54	No	No	0	7	4
238	R:R:I121	R:R:V103	1.54	No	No	0	4	3
239	R:R:I249	R:R:V253	1.54	No	No	0	7	6
240	R:R:K71	R:R:V67	1.52	No	No	0	5	4
241	R:R:I182	R:R:T178	1.52	No	No	0	3	3
242	R:R:I195	R:R:T199	1.52	No	No	0	4	4
243	R:R:M281	R:R:V278	1.52	No	No	0	3	1
244	R:R:K164	R:R:T162	1.5	No	No	0	4	8
245	R:R:L217	R:R:V213	1.49	No	No	0	4	3
246	R:R:L247	R:R:V213	1.49	Yes	No	0	8	3
247	R:R:L54	R:R:T53	1.47	No	No	0	6	3
248	R:R:D189	R:R:S188	1.47	No	No	0	5	4
249	R:R:L207	R:R:T203	1.47	No	No	0	5	4
250	R:R:I245	R:R:I249	1.47	No	No	0	7	7
251	R:R:I245	R:R:M241	1.46	No	No	0	7	4
252	R:R:E49	R:R:S47	1.44	No	No	0	3	4
253	R:R:K311	R:R:K314	1.44	No	No	0	4	5
254	R:R:I226	R:R:L229	1.43	No	No	0	6	4
255	R:R:I223	R:R:N240	1.42	No	No	0	5	7
256	R:R:L221	R:R:M218	1.41	No	No	0	5	5
257	R:R:A244	R:R:F216	1.39	No	Yes	0	8	6
258	R:R:H222	R:R:I226	1.33	No	No	0	7	6
259	R:R:S190	R:R:Y187	1.27	No	No	0	4	4
260	R:R:L183	R:R:Y187	1.17	No	No	0	5	4
261	R:R:R305	R:R:R310	1.07	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H4	12.2425	4	2	0
2	L:L:?5	7.64167	6	1	0
3	L:L:R6	9.30667	6	1	0
4	L:L:W7	9.1875	4	1	0
5	R:R:F51	9.13	5	2	6
6	R:R:S58	5.13	4	0	8
7	R:R:N62	7.445	4	0	9
8	R:R:L75	8.14	4	0	9
9	R:R:M79	5.19	4	0	8
10	R:R:Y80	6.7225	4	0	8
11	R:R:F82	6.3075	4	0	8
12	R:R:L86	5.6225	4	0	9
13	R:R:D126	8.805	4	1	4
14	R:R:D146	5.895	4	6	9
15	R:R:R147	5.8875	4	3	9
16	R:R:Y148	11.0725	4	7	8
17	R:R:F152	15.165	4	7	6
18	R:R:Y157	8.388	5	6	9
19	R:R:W174	4.7475	4	0	9
20	R:R:F184	5.90429	7	0	4
21	R:R:I185	5.39	4	1	5
22	R:R:F201	9.06333	6	1	6
23	R:R:Y212	4.87571	7	3	9
24	R:R:F216	2.9175	4	0	6
25	R:R:L247	2.8775	4	0	8
26	R:R:F254	6.405	4	1	8
27	R:R:W258	7.215	8	1	7
28	R:R:F261	5.568	5	1	5
29	R:R:F262	11.2925	4	1	5
30	R:R:L265	4.575	4	1	5
31	R:R:F267	5.895	4	4	4
32	R:R:C271	4.1175	4	4	5
33	R:R:F284	7.64833	6	1	3
34	R:R:Y287	9.04	4	0	5
35	R:R:Y302	4.725	6	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?5	R:R:F284	12.1252	4.13	Yes	Yes	1	0	3
2	L:L:?5	R:R:D126	40.4713	10.35	Yes	Yes	1	0	4
3	R:R:N285	R:R:Q43	12.9493	7.92	No	No	0	4	3
4	R:R:F284	R:R:Q43	14.6223	3.51	Yes	No	0	3	3
5	L:L:?5	R:R:E100	14.3324	4.49	Yes	No	0	0	5
6	L:L:?5	R:R:I129	10.2948	14.51	Yes	No	0	0	5
7	L:L:?5	R:R:F261	93.2831	6.19	Yes	Yes	1	0	5
8	R:R:D126	R:R:I185	35.1789	4.2	Yes	Yes	1	4	5
9	R:R:F284	R:R:H264	43.2003	15.84	Yes	No	0	3	4
10	R:R:H264	R:R:Y287	33.7792	6.53	No	Yes	0	4	5
11	R:R:F261	R:R:F262	85.0133	7.5	Yes	Yes	1	5	5
12	R:R:F262	R:R:W258	63.2185	4.01	Yes	Yes	1	5	7
13	R:R:N294	R:R:W258	52.3439	12.43	No	Yes	0	9	7
14	R:R:D298	R:R:N294	51.1512	12.12	No	No	0	9	9
15	R:R:D298	R:R:D90	56.5968	6.65	No	No	0	9	9
16	R:R:D90	R:R:N62	38.438	14.81	No	Yes	0	9	9
17	R:R:N62	R:R:S58	15.5955	4.47	Yes	Yes	0	9	8
18	R:R:I296	R:R:S58	20.4696	4.64	No	Yes	0	6	8
19	R:R:F261	R:R:I291	54.4393	3.77	Yes	No	0	5	6
20	R:R:I291	R:R:W258	54.6049	7.05	No	Yes	0	6	7
21	R:R:D90	R:R:S295	16.7426	8.83	No	No	0	9	9
22	R:R:S295	R:R:S58	15.111	4.89	No	Yes	0	9	8
23	R:R:I296	R:R:L54	17.078	4.28	No	No	0	6	6
24	R:R:M91	R:R:N62	12.1998	5.61	No	Yes	0	7	9
25	R:R:I63	R:R:M91	10.4812	2.92	No	No	0	4	7
26	R:R:N62	R:R:P299	10.4812	4.89	Yes	No	0	9	9
27	R:R:F201	R:R:F262	36.1024	30.01	Yes	Yes	1	6	5
28	R:R:F201	R:R:F254	35.154	4.29	Yes	Yes	1	6	8
29	R:R:F254	R:R:M208	100	6.22	Yes	No	0	8	8
30	R:R:M208	R:R:Y212	99.089	4.79	No	Yes	0	8	9
31	R:R:R147	R:R:Y212	71.0991	8.23	Yes	Yes	3	9	9
32	R:R:M79	R:R:R147	76.408	7.44	Yes	Yes	0	8	9
33	R:R:M79	R:R:Y80	46.3807	4.79	Yes	Yes	0	8	8
34	R:R:L75	R:R:Y80	28.7891	9.38	Yes	Yes	0	9	8
35	R:R:L309	R:R:L75	12.8748	4.15	No	Yes	0	8	9
36	R:R:A303	R:R:L309	21.8362	3.15	No	No	0	8	8
37	R:R:A303	R:R:V65	18.2168	3.39	No	No	0	8	9
38	R:R:A87	R:R:V65	14.5892	3.39	No	No	0	9	9
39	R:R:A87	R:R:I66	10.9533	3.25	No	No	0	9	7
40	R:R:F254	R:R:W258	65.9351	9.02	Yes	Yes	1	8	7
41	R:R:S306	R:R:Y80	14.2828	7.63	No	Yes	0	7	8
42	R:R:L309	R:R:S306	12.6429	6.01	No	No	0	8	7
43	R:R:D146	R:R:M79	33.5307	4.16	Yes	Yes	0	9	8
44	R:R:D146	R:R:F82	15.0323	8.36	Yes	Yes	0	9	8
45	R:R:F82	R:R:V166	10.7959	5.24	Yes	No	0	8	7
46	R:R:D298	R:R:L86	45.2087	6.79	No	Yes	0	9	9
47	R:R:L86	R:R:S139	24.7184	4.5	Yes	No	0	9	8
48	R:R:S139	R:R:S85	23.1655	4.89	No	No	0	8	9
49	R:R:I170	R:R:S85	10.9036	4.64	No	No	0	7	9
50	R:R:F82	R:R:I170	10.0712	5.02	Yes	No	0	8	7
51	R:R:S85	R:R:W174	14.1088	4.94	No	Yes	0	9	9
52	R:R:L140	R:R:L86	10.2493	6.92	No	Yes	0	8	9
53	R:R:I143	R:R:L86	21.6664	4.28	No	Yes	0	9	9
54	R:R:E100	R:R:I125	12.4441	4.1	No	No	0	5	5
55	R:R:C130	R:R:I185	64.0426	4.91	No	Yes	0	4	5
56	R:R:C130	R:R:G181	34.2844	3.92	No	No	0	4	6
57	R:R:C130	R:R:F184	26.5653	4.19	No	Yes	0	4	4
58	R:R:Y212	R:R:Y302	15.5872	3.97	Yes	Yes	3	9	9
59	R:R:D146	R:R:M161	11.1272	4.16	Yes	No	6	9	7
60	R:R:M215	R:R:Y212	28.7974	3.59	No	Yes	0	9	9
61	R:R:M215	R:R:Y148	26.6233	3.59	No	Yes	0	9	8
62	R:R:F152	R:R:Y148	17.8483	22.69	Yes	Yes	7	6	8
63	R:R:F152	R:R:M218	13.4545	9.95	Yes	No	0	6	5
64	R:R:G181	R:R:S131	30.5077	1.86	No	No	0	6	4
65	R:R:S131	R:R:T178	26.7227	3.2	No	No	0	4	3
66	R:R:I182	R:R:T178	22.9294	1.52	No	No	0	3	3
67	R:R:I182	R:R:I186	19.1279	2.94	No	No	0	3	4
68	R:R:I186	R:R:Y187	15.318	7.25	No	No	0	4	4
69	R:R:L247	R:R:Y212	24.2008	3.52	Yes	Yes	0	8	9
70	R:R:F216	R:R:L247	15.4009	3.65	Yes	Yes	0	6	8
71	R:R:F280	R:R:Y287	20.1549	17.54	No	Yes	0	2	5
72	R:R:F267	R:R:F280	16.1628	8.57	Yes	No	4	4	2
73	R:R:I301	R:R:Y302	16.0427	4.84	No	Yes	0	9	9
74	R:R:C293	R:R:I289	12.3571	1.64	No	No	0	4	5
75	R:R:C293	R:R:I297	12.7008	1.64	No	No	0	4	7
76	R:R:I297	R:R:I301	14.8128	2.94	No	No	0	7	9
77	R:R:L54	R:R:T53	13.6782	1.47	No	No	0	6	3
78	R:R:T53	R:R:V52	10.27	1.59	No	No	0	3	4
79	L:L:?5	L:L:R6	44.4799	6.18	Yes	Yes	1	0	0
80	L:L:R6	R:R:I185	36.1065	6.26	Yes	Yes	1	0	5
81	R:R:F261	R:R:F284	48.004	4.29	Yes	Yes	1	5	3
82	R:R:I194	R:R:L265	13.0404	5.71	No	Yes	0	4	5
83	R:R:F262	R:R:L265	13.7941	3.65	Yes	Yes	1	5	5
84	R:R:I143	R:R:R147	11.7815	3.76	No	Yes	3	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:D122	8.34	0	No	No	0	8	0	1
L:L:?3	R:R:I104	5.81	0	No	No	0	4	0	1
L:L:H4	R:R:F51	22.63	2	Yes	Yes	0	6	0	1
L:L:H4	R:R:T101	6.85	2	Yes	No	0	6	0	1
L:L:H4	R:R:N285	5.1	2	Yes	No	0	4	0	1
L:L:?5	R:R:E100	4.49	1	Yes	No	0	5	0	1
L:L:?5	R:R:D126	10.35	1	Yes	Yes	0	4	0	1
L:L:?5	R:R:I129	14.51	1	Yes	No	0	5	0	1
L:L:?5	R:R:F261	6.19	1	Yes	Yes	0	5	0	1
L:L:?5	R:R:F284	4.13	1	Yes	Yes	0	3	0	1
L:L:R6	R:R:N123	4.82	1	Yes	No	0	5	0	1
L:L:R6	R:R:D126	16.68	1	Yes	Yes	0	4	0	1
L:L:R6	R:R:I185	6.26	1	Yes	Yes	0	5	0	1
L:L:R6	R:R:S188	7.91	1	Yes	No	0	4	0	1
L:L:W7	R:R:S188	3.71	1	Yes	No	0	4	0	1
L:L:W7	R:R:I194	9.4	1	Yes	No	0	4	0	1
L:L:W7	R:R:Y268	9.65	1	Yes	No	0	5	0	1
L:L:C8	R:R:F284	8.38	0	No	Yes	0	3	0	1
R:R:N285	R:R:Q43	7.92	2	No	No	4	3	1	2
R:R:F51	R:R:V46	6.55	2	Yes	No	6	5	1	2
R:R:I289	R:R:V46	6.14	2	No	No	5	5	2	2
R:R:F51	R:R:T101	9.08	2	Yes	No	6	6	1	1
R:R:F51	R:R:N285	3.62	2	Yes	No	6	4	1	1
R:R:F51	R:R:I289	3.77	2	Yes	No	6	5	1	2
R:R:I129	R:R:S96	4.64	0	No	No	5	6	1	2
R:R:I129	R:R:N97	11.33	0	No	No	5	6	1	2
R:R:E100	R:R:I125	4.1	0	No	No	5	5	1	2
R:R:N123	R:R:V119	5.91	0	No	No	5	3	1	2
R:R:D122	R:R:D126	3.99	0	No	Yes	8	4	1	1
R:R:D126	R:R:I185	4.2	1	Yes	Yes	4	5	1	1
R:R:I185	R:R:S127	6.19	1	Yes	No	5	5	1	2
R:R:C130	R:R:I185	4.91	0	No	Yes	4	5	2	1
R:R:I194	R:R:L265	5.71	0	No	Yes	4	5	1	2
R:R:I194	R:R:I269	8.83	0	No	No	4	4	1	2
R:R:F261	R:R:F262	7.5	1	Yes	Yes	5	5	1	2
R:R:F261	R:R:L265	6.09	1	Yes	Yes	5	5	1	2
R:R:F261	R:R:F284	4.29	1	Yes	Yes	5	3	1	1
R:R:F261	R:R:I291	3.77	1	Yes	No	5	6	1	2
R:R:F262	R:R:L265	3.65	1	Yes	Yes	5	5	2	2
R:R:F284	R:R:H264	15.84	1	Yes	No	3	4	1	2
R:R:F284	R:R:L288	9.74	1	Yes	No	3	4	1	2
R:R:F284	R:R:Q43	3.51	1	Yes	No	3	3	1	2
R:R:D189	R:R:S188	1.47	0	No	No	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7PIU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.61
Number of Linked Nodes	238
Number of Links	261
Number of Hubs	35
Number of Links mediated by Hubs	131
Number of Communities	7
Number of Nodes involved in Communities	39
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	59528
Length Of Smallest Path	3
Average Path Length	13.5375
Length of Longest Path	29
Minimum Path Strength	1.22
Average Path Strength	6.40486
Maximum Path Strength	19.83
Minimum Path Correlation	0.7
Average Path Correlation	0.918708
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	43.5555
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.2733
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32245
Sequence	>7PIU_nogp_Chain_R C Y E Q L F V S P E V F V T L G V I S L L E N I L V I V A I A K N K N L H S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y A L Q Y H N I M T V K R V G I I I S C I W A A C T V S G I L F I I Y S D S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L P N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C P Q N P Y C V C F M S H F N L Y L I L I M C N S I I D P L I Y A L R S Q E L R K T F K E I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6W25	A	Peptide	Melanocortin	MC₄	Homo sapiens	SHU9119	Ca	-	2.75	2020-04-29	doi.org/10.1126/science.aaz8995
	7F53	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F53 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	α-MSH	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-	Gs/β1/γ2	3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F54 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Afamelanotide	-		3	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F55 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Bremelanotide	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7F58 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	THIQ	-		3.1	2021-11-03	doi.org/10.1038/s41422-021-00552-3
	7PIU	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIU (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.58	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	Gs/β1/γ2	2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7PIV (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.86	2021-11-17	doi.org/10.1038/s41422-021-00569-8
	7AUE	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-	chim(NtGi1L-Gs)/β1/γ2	2.97	2021-04-28	doi.org/10.1126/science.abf7958
	7AUE (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	Setmelanotide	-		2.97	2021-04-28	doi.org/10.1126/science.abf7958
	8WKY	A	Peptide	Melanocortin	MC₄	Homo sapiens	PG-934	-	-	2.9	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8WKZ	A	Peptide	Melanocortin	MC₄	Homo sapiens	SBL-MC-31	-	-	3.3	2024-08-07	doi.org/10.1021/acs.jmedchem.3c01822
	8QJ2	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-	Gs	3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	8QJ2 (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	pN162	-		3.4	2024-09-25	doi.org/10.1038/s41467-024-50827-7
	9K3K	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3K (No Gprot)	A	Peptide	Melanocortin	MC₄	Homo sapiens	-	-		3.12	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7PIU_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.