Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:D49 5.9025430
2L:L:N50 6.185630
3L:L:C52 5.2075430
4L:L:C55 4.19430
5L:L:K58 4.3925400
6L:L:F60 4.87410
7L:L:F61 5.348530
8L:L:F62 8.0625410
9L:L:L63 5.052530
10L:L:C74 6.115430
11L:L:P79 4.085410
12L:L:Y82 8.708510
13L:L:R86 7.552510
14L:L:C93 4.2225410
15L:L:I98 4.044220
16L:L:N100 7.73754220
17L:L:F105 7.42167610
18L:L:F109 5.56833610
19L:L:C110 4.91254220
20L:L:K114 4.4645220
21L:L:H120 9.44270
22L:L:R123 6.1475400
23L:L:P129 5.1525270
24L:L:C141 5.2454270
25M:M:N50 6.45167640
26M:M:K58 9.378550
27M:M:L59 3.6125440
28M:M:F61 5.60167640
29M:M:F62 7.88754110
30M:M:L63 5.2325400
31M:M:Y71 7.1925110
32M:M:Y82 8.435110
33M:M:R86 6.14143750
34M:M:N100 8.05254160
35M:M:F105 6.41333650
36M:M:F109 5.04143750
37M:M:C110 4.91254160
38M:M:K114 3.945160
39M:M:F117 7.41754160
40M:M:H120 6.2054240
41M:M:P129 4.60254240
42M:M:C141 4.20254240
43E:E:T58 4.5754178
44E:E:F60 5.965178
45E:E:T79 2.865469
46E:E:F85 7.084418
47E:E:E95 12.7675408
48E:E:H102 8539
49E:E:Y116 6.132509
50E:E:Y118 6.154297299
51E:E:W120 5.342509
52E:E:K125 6.6125439
53E:E:R145 4.884549
54E:E:I155 3.015409
55E:E:F156 4.9365559
56E:E:D157 5.42439
57E:E:N161 6.88754569
58E:E:I165 4.59754289
59E:E:L168 3.755409
60E:E:N169 4.20254289
61E:E:R178 6.464509
62E:E:Y182 7.2485289
63E:E:M192 3.905439
64E:E:V195 3.7475439
65E:E:R202 8.05469
66E:E:R204 10.56569
67E:E:Q206 4.464179
68E:E:H207 5.3854419
69E:E:P209 7.694177
70E:E:P210 5.884179
71E:E:E215 9.554589
72E:E:Y216 5.342589
73R:R:R40 7.05254593
74R:R:V41 5.9054587
75R:R:S44 4.8954427
76R:R:D63 6.19754429
77R:R:N67 5.3485609
78R:R:L72 5.6325407
79R:R:D75 5.4054384
80R:R:F80 4.556507
81R:R:L88 5.006509
82R:R:I96 4.7854619
83R:R:H97 13.44254388
84R:R:K99 5.614383
85R:R:L110 4.154579
86R:R:L112 4.1475409
87R:R:Q113 5.1425419
88R:R:N115 4.4554629
89R:R:V120 3.9075407
90R:R:L131 3.4625479
91R:R:L134 4.54333679
92R:R:R135 7.852519
93R:R:D137 6.094519
94R:R:N139 5.164629
95R:R:I141 5.02409
96R:R:V144 4.175479
97R:R:P145 3.48579
98R:R:F149 5.58579
99R:R:R156 6.0825409
100R:R:H157 4.97167609
101R:R:L158 3.335479
102R:R:W159 8.66519
103R:R:D161 7.006519
104R:R:V168 3.515408
105R:R:H171 5.6925471
106R:R:P172 4.2725479
107R:R:L176 4.355409
108R:R:Q180 3.7075419
109R:R:L182 4.025408
110R:R:T183 5.06419
111R:R:L184 3.825409
112R:R:I192 3.244528
113R:R:F197 3.798509
114R:R:V204 4.51519
115R:R:V205 5.212519
116R:R:H207 6.31619
117R:R:L208 4.442529
118R:R:H209 5.18519
119R:R:N210 9.73419
120R:R:N211 5.016529
121R:R:I213 4.98333629
122R:R:L216 3.302526
123R:R:H219 9.47754635
124R:R:C220 4.546525
125R:R:F221 6.14409
126R:R:T229 4.81419
127R:R:L230 4.635409
128R:R:D231 6.5075419
129R:R:N233 6.2175419
130R:R:N235 6.6429
131R:R:L237 2.91333628
132R:R:F240 5.16714729
133R:R:P241 5.5429
134R:R:K251 6.5525409
135R:R:L253 4.9429
136R:R:F255 4.645629
137R:R:H256 12.99419
138R:R:N258 5.645429
139R:R:I260 3.274529
140R:R:F268 3.69333629
141R:R:N271 3.46167629
142R:R:L274 5.425429
143R:R:I277 4.465428
144R:R:N282 4.2429
145R:R:H293 4.954647
146R:R:I303 3.62408
147R:R:F312 7.31754188
148R:R:T318 3.6854328
149R:R:T325 5.624318
150R:R:L326 3.5765187
151R:R:T327 6.035319
152R:R:I331 5.34254188
153R:R:Q342 4.25328
154R:R:D349 4.73254318
155R:R:L350 4.1725409
156R:R:N353 5.9465189
157R:R:P359 4.41409
158R:R:G363 2.59754654
159R:R:I370 3.8375407
160R:R:L372 3.618508
161R:R:N375 6.4345189
162R:R:L388 4.0675408
163R:R:L391 3.8475409
164R:R:L396 3.1875409
165R:R:I401 4.66408
166R:R:I404 4.0825407
167R:R:R407 5.73254394
168R:R:F409 5.2045238
169R:R:I415 5.354237
170R:R:L418 3.601676239
171R:R:F422 7.20754434
172R:R:F428 5.2154234
173R:R:L433 5.734239
174R:R:L436 3.6165238
175R:R:Q438 9.78254309
176R:R:L439 5.63254238
177R:R:K440 9.71254308
178R:R:F456 5.74405
179R:R:Y466 5.2075406
180R:R:Y468 9.9065109
181R:R:F473 5.57408
182R:R:Y534 4.1265104
183R:R:L535 4.3165109
184R:R:L536 5.90754105
185R:R:M540 7.03505
186R:R:I541 8.5925487
187R:R:F549 7.2754445
188R:R:V551 3.75406
189R:R:N556 6.3954699
190R:R:F576 4.01254336
191R:R:N584 4.0225409
192R:R:F586 3.9325406
193R:R:M587 5.80754686
194R:R:D598 5.24109
195R:R:F605 6.015109
196R:R:W612 5.5975409
197R:R:E613 5.2985109
198R:R:F627 4.88405
199R:R:E630 6.286598
200R:R:I633 3.02833696
201R:R:F634 4.184597
202R:R:L635 4.864715
203R:R:E642 7.9285338
204R:R:R643 7.248336338
205R:R:F670 4.024713
206R:R:P680 8.06754127
207R:R:E686 6.7665124
208R:R:Y687 6.11754125
209R:R:P691 4.3425109
210R:R:L692 3.6754127
211R:R:L694 5.08754127
212R:R:P695 5.345129
213R:R:P697 5.9754127
214R:R:F706 5.1325125
215R:R:N714 5.9125499
216R:R:F718 3.618596
217R:R:I724 3.75406
218R:R:M745 4.414507
219R:R:W751 8.08754578
220R:R:F754 8.8475408
221R:R:I758 2.475407
222R:R:F759 8.34254729
223R:R:E780 7.34488
224R:R:I781 5.61408
225R:R:F789 3.1507
226R:R:P791 4.0654689
227R:R:Y801 13.41754709
228R:R:F808 5.795607
229R:R:L814 4.1725404
230S:S:P52 3.5485258
231S:S:I64 5.138336256
232S:S:N67 5.0625259
233S:S:F77 5.3525407
234S:S:F80 8.015407
235S:S:E85 6.0125408
236S:S:L86 4.6775408
237S:S:I96 4.8325409
238S:S:H97 12.23754458
239S:S:K99 4.174453
240S:S:L110 4.706509
241S:S:Q113 5.21714759
242S:S:N114 3.38459
243S:S:V120 3.715137
244S:S:L134 4.7175409
245S:S:R135 10.82459
246S:S:L136 4.1956139
247S:S:D137 9.682559
248S:S:I141 5.1785139
249S:S:V144 3.7754139
250S:S:P145 5.324139
251S:S:F149 4.6509
252S:S:H157 6.805659
253S:S:W159 7.604559
254S:S:N163 5.88754139
255S:S:L176 4.09409
256S:S:L182 4.29833608
257S:S:L184 4.438509
258S:S:L186 4.425459
259S:S:I192 3.3045198
260S:S:F195 5.94754462
261S:S:F197 3.3025199
262S:S:L203 4.1554749
263S:S:V204 4.845459
264S:S:V205 4.88659
265S:S:L206 4.1525409
266S:S:H207 7.315459
267S:S:L208 4.1625199
268S:S:H209 4.225409
269S:S:N210 7.3375409
270S:S:N211 5.60254199
271S:S:I213 4.8285199
272S:S:L216 4.1654196
273S:S:H219 11.31754465
274S:S:C220 4.2285195
275S:S:N233 5.9285479
276S:S:Y234 9.00254476
277S:S:F240 5.512509
278S:S:L247 3.4409
279S:S:L250 3.10754149
280S:S:K251 4.81409
281S:S:L253 4.718509
282S:S:F255 4.9356149
283S:S:H256 11.275479
284S:S:N258 5.774149
285S:S:F268 4.2985149
286S:S:N271 3.246149
287S:S:L274 3.5085149
288S:S:R275 6.9525405
289S:S:I277 3.6865148
290S:S:N282 3.5454149
291S:S:V287 3.53409
292S:S:F292 3.8025409
293S:S:V309 3.60754347
294S:S:T325 4.434488
295S:S:L326 3.9675407
296S:S:T327 6.45254489
297S:S:T329 5.81254348
298S:S:I331 4.8885348
299S:S:Q342 5.28408
300S:S:L350 3.892509
301S:S:S351 4.8825409
302S:S:N353 5.9465349
303S:S:P359 4.0025409
304S:S:I370 4.212507
305S:S:L372 3.8375408
306S:S:Q373 5.575778
307S:S:R392 8.16406
308S:S:L394 5.2225407
309S:S:I401 4.98754158
310S:S:S406 2.524403
311S:S:R407 5.38754404
312S:S:L418 4.054509
313S:S:L425 4.25754159
314S:S:F428 4.0185154
315S:S:N437 3.7125465
316S:S:L439 4.7845158
317S:S:L441 4.02254158
318S:S:N458 3.3575464
319S:S:L462 4.4525407
320S:S:Y468 9.8154209
321S:S:I519 5.44754174
322S:S:L535 6.2954209
323S:S:L536 4.0085205
324S:S:F549 3.7765805
325S:S:N556 4.7654369
326S:S:F576 3.8354266
327S:S:I580 3.465367
328S:S:N584 5.048336369
329S:S:Y590 7.5725405
330S:S:T595 3.8545807
331S:S:F605 5.6225209
332S:S:W612 4.055609
333S:S:E613 5.30754209
334S:S:F623 4.3825404
335S:S:F627 5.585405
336S:S:E630 6.1045848
337S:S:I633 3.006506
338S:S:F634 4.13254847
339S:S:E642 6.8345268
340S:S:R643 6.3945268
341S:S:E686 5.43504
342S:S:Y687 5.55254835
343S:S:P691 3.193336209
344S:S:L694 5.08754497
345S:S:P697 4.9754497
346S:S:F706 6.1845865
347S:S:N714 6.2175409
348S:S:F718 3.03406
349S:S:Y725 5.9425408
350S:S:W751 6.0554218
351S:S:N756 4.005409
352S:S:F759 4.91409
353S:S:F760 4.03408
354S:S:F766 5.725409
355S:S:S778 2.98406
356S:S:I781 4.542588
357S:S:F789 3.684507
358S:S:F790 3.955405
359S:S:N797 4.441676369
360S:S:P798 3.98254369
361S:S:Y801 6.6365819
362S:S:N805 9.50254818
363S:S:F808 8.09407
364S:S:D811 5.45409
365T:T:V64 4.385299
366T:T:Y77 5.38254676
367T:T:T78 3.1975409
368T:T:F85 6.8725378
369T:T:E95 11.44408
370T:T:V99 5.435467
371T:T:M101 5.0625469
372T:T:H102 7.862549
373T:T:L104 4.9075449
374T:T:Y116 5.258569
375T:T:Y118 5.55857769
376T:T:G119 3.398569
377T:T:W120 5.73143769
378T:T:K125 7.3225449
379T:T:E127 5.735449
380T:T:Q128 6.0975449
381T:T:L131 5.102549
382T:T:V139 2.605409
383T:T:R145 5.6275409
384T:T:F156 3.45667609
385T:T:D157 6.805449
386T:T:I165 4.934899
387T:T:R178 6.6509
388T:T:P179 3.575409
389T:T:Y182 6.8385899
390T:T:M192 5.305449
391T:T:R202 6.1885299
392T:T:R204 10.575299
393T:T:Q212 9.5225488
394T:T:E215 5.68589
395T:T:D218 8.746589
396T:T:M219 7.95589
397T:T:F222 5.12589
398T:T:L223 5.7325489
399T:T:V232 2.254219
400T:T:L236 5.8854219
401T:T:K239 5.77254219
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:C43 L:L:C52 99.68587.28NoYes300
2L:L:C43 L:L:C55 1003.64NoYes300
3L:L:C55 L:L:Q56 1003.05YesNo000
4E:E:A164 E:E:N161 11.30874.69NoYes099
5E:E:A164 E:E:V158 12.43953.39NoNo099
6E:E:V158 E:E:Y182 13.56985.05NoYes2899
7E:E:R84 E:E:Y182 44.09719.26NoYes089
8E:E:R84 E:E:T58 45.22756.47NoYes088
9E:E:F60 E:E:T58 23.655.19YesYes1788
10E:E:F60 E:E:P209 12.6910.11YesYes1787
11E:E:P209 E:E:Q206 25.88739.47YesYes1779
12E:E:Q206 E:E:S93 38.90991.44YesNo1799
13E:E:S93 T:T:Q206 39.22071.44NoNo099
14T:T:F60 T:T:Q206 40.87962.34NoNo089
15T:T:F60 T:T:T58 1005.19NoNo088
16T:T:R84 T:T:T58 1006.47NoNo088
17T:T:R84 T:T:Y182 1007.2NoYes089
18T:T:S86 T:T:Y182 1005.09NoYes099
19T:T:L168 T:T:S86 1007.51NoNo099
20T:T:L168 T:T:V139 1002.98NoYes099
21T:T:F156 T:T:V139 1002.62YesYes099
22T:T:F156 T:T:V124 1005.24YesNo099
23T:T:P103 T:T:V124 1003.53NoNo099
24T:T:H102 T:T:P103 10010.68YesNo499
25M:M:L63 T:T:H102 1005.14YesYes009
26M:M:L63 M:M:Q70 1007.99YesNo000
27M:M:Q70 M:M:R65 10016.35NoNo000
28M:M:R65 T:T:V99 1003.92NoYes607
29T:T:V99 T:T:W120 10012.26YesYes679
30T:T:G119 T:T:W120 1002.81YesYes699
31E:E:R202 T:T:G119 1006YesYes699
32E:E:E95 E:E:R202 10018.61YesYes089
33E:E:E95 T:T:E95 1003.81YesYes088
34T:T:E95 T:T:R202 10015.12YesYes089
35E:E:G119 T:T:R202 1004.5NoYes2999
36E:E:G119 E:E:W120 1002.81NoYes099
37E:E:V99 E:E:W120 1004.9NoYes079
38E:E:V99 E:E:Y116 1002.52NoYes079
39E:E:Y116 L:L:R65 10013.38YesNo090
40L:L:Q70 L:L:R65 10014.02NoNo000
41L:L:L63 L:L:Q70 1009.32YesNo300
42L:L:F61 L:L:L63 1006.09YesYes300
43L:L:C55 L:L:F61 1002.79YesYes300
44E:E:P210 E:E:T58 23.23833.5YesYes1798
45E:E:P209 E:E:P210 13.70567.79YesYes1779
46E:E:F60 S:S:I519 13.22116.28YesYes1784
47E:E:Q206 S:S:I519 13.26665.49YesYes1794
48T:T:V158 T:T:Y182 1005.05NoYes8999
49T:T:A164 T:T:V158 1003.39NoNo099
50T:T:A164 T:T:V139 1003.39NoYes099
51M:M:R65 T:T:Y116 10010.29NoYes609
52T:T:W120 T:T:Y116 1002.89YesYes699
53T:T:G119 T:T:T152 1003.64YesNo099
54E:E:E95 T:T:T152 1004.23YesNo089
55E:E:M101 E:E:W120 1005.82NoYes099
56E:E:M101 E:E:Y116 1007.18NoYes099
57E:E:H102 L:L:N50 10012.75YesYes390
58L:L:D49 L:L:N50 95.41042.69YesYes300
59E:E:H102 E:E:L104 13.9686.43YesNo399
60E:E:K125 L:L:N50 1005.6YesYes390
61E:E:M192 L:L:D49 90.86775.54YesYes390
62E:E:K125 E:E:M192 90.86722.88YesYes399
63E:E:M192 E:E:V195 1003.04YesYes399
64E:E:V195 L:L:M68 1003.04YesNo390
65E:E:A201 L:L:M68 1003.22NoNo090
66E:E:A201 E:E:I194 1001.62NoNo099
67E:E:I194 E:E:Q198 99.95535.49NoNo099
68E:E:K197 E:E:Q198 81.78174.07NoNo099
69E:E:K197 E:E:N196 45.434413.99NoNo099
70E:E:N196 L:L:R69 36.34753.62NoNo090
71L:L:R69 L:L:Y71 18.17389.26NoNo5000
72L:L:C52 L:L:E73 81.57113.04YesNo000
73L:L:C74 L:L:L59 1007.94YesNo000
74L:L:H76 L:L:L59 1006.43NoNo000
75L:L:H76 R:R:G90 1003.18NoNo009
76R:R:G90 R:R:N114 1005.09NoNo099
77L:L:K58 R:R:N114 1004.2YesNo009
78L:L:K58 R:R:H140 36.25647.86YesNo008
79L:L:K58 R:R:D162 1004.15YesNo009
80L:L:E73 L:L:L75 77.04273.98NoNo000
81L:L:L75 L:L:P79 72.51443.28NoYes000
82L:L:F62 L:L:P79 22.66664.33YesYes100
83L:L:C93 L:L:F62 13.60712.79YesYes100
84L:L:C93 L:L:F60 18.15912.79YesYes100
85L:L:P79 L:L:Y82 40.79136.95YesYes100
86L:L:C93 L:L:Y82 13.61144.03YesYes100
87L:L:F60 L:L:G84 18.1264.52YesNo000
88L:L:F60 L:L:R86 18.16158.55YesYes100
89E:E:I98 E:E:V195 18.17374.61NoYes389
90R:R:A138 R:R:N114 1004.69NoNo099
91R:R:A138 R:R:D137 1003.09NoYes199
92R:R:D137 R:R:R135 1004.76YesYes199
93L:L:R95 L:L:Y82 18.130515.43NoYes000
94L:L:A94 L:L:Y83 18.1266.67NoNo000
95L:L:C104 L:L:Y83 54.37794.03NoNo000
96L:L:C101 L:L:C104 1001.82NoNo000
97L:L:C101 L:L:I98 1004.91NoYes2200
98L:L:I98 L:L:R123 1002.51YesYes000
99L:L:R123 R:R:K251 1004.95YesYes009
100R:R:E252 R:R:K251 1006.75NoYes099
101R:R:E252 R:R:T229 1004.23NoYes099
102R:R:H207 R:R:T229 1002.74YesYes199
103R:R:H207 R:R:T183 1005.48YesYes199
104R:R:D161 R:R:T183 1007.23YesYes199
105L:L:R86 R:R:D161 10010.72YesYes109
106L:L:K107 L:L:Y83 18.1265.97NoNo000
107R:R:D162 R:R:L186 1008.14NoNo099
108L:L:P88 R:R:L186 18.12463.28NoNo109
109R:R:L186 R:R:N210 90.62938.24NoYes199
110L:L:R95 L:L:R97 13.59795.33NoNo000
111L:L:C104 L:L:C96 36.25193.64NoNo000
112L:L:E99 L:L:I98 1005.47NoYes000
113L:L:C110 L:L:I98 72.50323.27YesYes2200
114L:L:E99 L:L:N100 1007.89NoYes000
115L:L:K114 L:L:N100 1004.2YesYes2200
116L:L:F117 L:L:N100 36.251815.71NoYes2200
117L:L:C110 L:L:C124 18.12633.64YesNo2200
118L:L:D102 L:L:K114 54.37786.91NoYes000
119L:L:D102 L:L:K112 36.25195.53NoNo000
120L:L:K112 L:L:S103 18.1263.06NoNo000
121R:R:D161 R:R:W159 1004.47YesYes199
122L:L:F105 R:R:W159 10014.03YesYes109
123L:L:F105 R:R:T183 1003.89YesYes109
124L:L:F105 L:L:S106 45.31287.93YesNo000
125L:L:S106 R:R:H207 18.12545.58NoYes009
126L:L:F105 L:L:F109 1006.43YesYes100
127R:R:H157 R:R:W159 1003.17YesYes099
128L:L:F109 R:R:H157 1005.66YesYes009
129L:L:F105 R:R:A181 45.31358.32YesNo009
130R:R:A181 R:R:H157 27.1882.93NoYes099
131L:L:F105 R:R:V205 1003.93YesYes109
132R:R:H207 R:R:V205 1004.15YesYes199
133L:L:D108 L:L:R123 18.125910.72NoYes000
134L:L:F109 L:L:G122 72.49986.02YesNo000
135L:L:F109 R:R:Q180 1003.51YesYes109
136R:R:H157 R:R:R156 1005.64YesYes099
137R:R:Q180 R:R:R156 54.38557.01YesYes099
138L:L:F109 R:R:V204 1006.55YesYes109
139R:R:V204 R:R:V205 1004.81YesYes199
140L:L:C110 L:L:C113 36.25175.46YesNo2200
141L:L:T111 R:R:H157 27.18816.85NoYes009
142L:L:C113 L:L:L119 18.12597.94NoNo000
143L:L:G116 L:L:K114 18.1263.49NoYes000
144L:L:D126 L:L:F117 18.1263.58NoNo000
145L:L:C128 L:L:P129 1003.77NoYes2700
146L:L:H120 L:L:P129 1004.58YesYes2700
147L:L:H120 L:L:R121 10012.41YesNo000
148L:L:R121 R:R:V204 1002.62NoYes009
149L:L:C128 L:L:C141 1007.28NoYes2700
150L:L:C141 L:L:H120 1005.9YesYes2700
151L:L:C141 L:L:Y118 1004.03YesNo2700
152L:L:M139 L:L:Y118 1004.79NoNo000
153L:L:F132 L:L:H120 10014.71NoYes2700
154L:L:R121 R:R:N226 1008.44NoNo008
155L:L:F125 L:L:R123 18.12596.41NoYes000
156L:L:E127 L:L:P129 1007.86NoYes000
157L:L:F132 L:L:G131 1003.01NoNo000
158M:M:F61 M:M:L63 1006.09YesYes000
159M:M:C55 M:M:F61 1004.19NoYes400
160M:M:C55 M:M:L59 1003.17NoYes400
161M:M:L59 M:M:Q56 1002.66YesNo000
162M:M:L44 M:M:Q56 1002.66NoNo000
163M:M:R54 T:T:L131 1007.29NoYes409
164M:M:N50 T:T:K125 11.88646.99YesYes409
165M:M:F61 T:T:L104 1006.09YesYes409
166T:T:H102 T:T:L104 1007.71YesYes499
167M:M:H76 M:M:L59 1003.86NoYes000
168M:M:H76 S:S:G90 12.583.18NoNo009
169S:S:G90 S:S:N114 11.18653.39NoYes099
170M:M:K58 S:S:N114 16.92182.8YesYes509
171M:M:H76 S:S:Q113 1003.71NoYes009
172S:S:N114 S:S:Q113 11.41012.64YesYes599
173M:M:R86 S:S:Q113 1003.5YesYes509
174M:M:K58 S:S:H140 11.5392.62YesNo008
175M:M:F60 M:M:R86 55.63412.83NoYes000
176M:M:F60 M:M:G84 52.78144.52NoNo000
177M:M:C78 M:M:G84 51.35511.96NoNo000
178M:M:C78 M:M:Y82 28.53072.69NoYes1100
179M:M:F62 M:M:Y82 19.971813.41YesYes1100
180M:M:C78 M:M:C93 21.3987.28NoNo1100
181M:M:C93 M:M:F62 19.97164.19NoYes1100
182M:M:F62 M:M:R64 37.09059.62YesNo1100
183M:M:R64 M:M:Y71 31.38448.23NoYes1100
184M:M:R69 M:M:Y71 22.82517.2NoYes1100
185M:M:R69 T:T:N196 19.97213.62NoNo009
186S:S:Q113 S:S:R135 1005.84YesYes599
187S:S:R135 S:S:W159 10013YesYes599
188M:M:F105 S:S:W159 10013.03YesYes509
189M:M:F105 S:S:V205 1002.62YesYes509
190S:S:T229 S:S:V205 30.82179.52NoYes099
191M:M:D108 S:S:T229 25.14845.78NoNo009
192M:M:D108 M:M:K107 19.56444.15NoNo000
193M:M:K107 M:M:Y83 13.97475.97NoNo000
194S:S:D137 S:S:Q113 10010.44YesYes599
195S:S:D137 S:S:W159 1003.35YesYes599
196M:M:R86 S:S:L186 43.26543.64YesYes509
197S:S:L186 S:S:N210 33.47514.12YesYes099
198M:M:F105 M:M:F109 1005.36YesYes500
199M:M:F109 S:S:V204 1006.55YesYes509
200S:S:E228 S:S:V204 1005.7NoYes099
201S:S:E228 S:S:K251 1005.4NoYes099
202M:M:R123 S:S:K251 1004.95NoYes009
203M:M:I98 M:M:R123 1002.51NoNo000
204S:S:H157 S:S:W159 1005.29YesYes599
205M:M:F109 S:S:H157 1004.53YesYes509
206S:S:V204 S:S:V205 1003.21YesYes599
207M:M:C110 M:M:I98 1003.27YesNo1600
208M:M:C110 M:M:C124 1003.64YesNo1600
209M:M:C124 M:M:N100 92.10531.57NoYes1600
210M:M:K114 M:M:N100 50.23934.2YesYes1600
211M:M:F117 M:M:N100 25.119613.29YesYes1600
212M:M:D102 M:M:K114 25.11972.77NoYes000
213M:M:D102 M:M:K112 16.74655.53NoNo000
214M:M:F109 S:S:Q180 11.1743.51YesNo009
215M:M:C110 M:M:C113 16.74645.46YesNo1600
216M:M:R121 S:S:V204 1003.92NoYes009
217M:M:H120 M:M:R121 10010.16YesNo000
218M:M:C141 M:M:H120 83.73254.42YesYes2400
219M:M:C141 M:M:Y118 25.11991.34YesNo2400
220M:M:H120 M:M:P129 66.9864.58YesYes2400
221M:M:F132 M:M:H120 25.125.66NoYes000
222M:M:R121 S:S:N226 10010.85NoNo008
223M:M:C128 M:M:P129 50.23963.77NoYes2400
224M:M:C128 M:M:C141 50.23977.28NoYes2400
225M:M:F132 M:M:G131 16.74673.01NoNo000
226M:M:C128 M:M:P134 83.73271.88NoNo000
227M:M:A133 M:M:P134 66.98621.87NoNo000
228M:M:A133 M:M:D136 50.23976.18NoNo000
229M:M:D136 M:M:E140 16.74665.2NoNo000
230E:E:H207 T:T:R208 1004.51YesNo099
231R:R:I519 T:T:R208 1002.51NoNo049
232R:R:I519 T:T:F60 1006.28NoNo048
233E:E:T152 T:T:E95 1007.06NoYes098
234E:E:R178 T:T:R204 10010.66YesYes099
235E:E:Y118 T:T:R204 10.12073.09YesYes2999
236E:E:E62 E:E:R204 65.3914.65NoYes699
237E:E:E62 E:E:T78 32.12214.23NoNo699
238E:E:E62 S:S:R460 32.122112.79NoNo699
239E:E:R204 T:T:Y118 65.74413.09YesYes699
240S:S:R392 S:S:T416 29.82897.76YesNo064
241S:S:N437 S:S:T416 41.3014.39YesNo054
242E:E:T78 S:S:N437 30.9752.92NoYes695
243S:S:N437 S:S:R460 30.9754.82YesNo659
244S:S:N437 S:S:N458 18.35652.72YesYes654
245E:E:L168 E:E:S86 19.2247.51YesNo099
246E:E:S86 E:E:Y182 20.35475.09NoYes099
247E:E:A88 E:E:L168 10.17793.15NoYes099
248E:E:C107 E:E:N109 13.61253.15NoNo098
249E:E:N109 E:E:N110 18.159.54NoNo089
250E:E:E113 E:E:N110 27.22147.89NoNo099
251E:E:E113 E:E:R149 31.718811.63NoNo5499
252T:T:R202 T:T:V64 27.3825.23YesYes2999
253E:E:I155 E:E:V121 13.63073.07YesNo099
254E:E:I155 E:E:V183 22.71743.07YesNo099
255E:E:A188 E:E:V183 31.80393.39NoNo099
256E:E:A188 E:E:D157 36.34744.63NoYes099
257E:E:D157 E:E:K125 45.43385.53YesYes399
258E:E:K177 E:E:R178 1002.48NoYes099
259E:E:K177 R:R:Q438 1006.78NoYes099
260T:T:R178 T:T:T152 22.81849.06YesNo099
261E:E:H207 E:E:R208 1006.77YesNo099
262E:E:R208 E:E:R211 1004.26NoNo098
263E:E:Q212 E:E:R208 15.15167.01NoNo089
264E:E:R211 E:E:Y216 1004.12NoYes089
265E:E:E215 E:E:Y216 10011.22YesYes899
266E:E:Y216 T:T:Q212 1003.38YesYes898
267E:E:E215 T:T:E215 1007.61YesYes899
268E:E:E215 T:T:D218 1003.9YesYes899
269T:T:D218 T:T:Q212 10016.97YesYes898
270E:E:Y216 S:S:S778 1003.82YesYes096
271S:S:I781 S:S:S778 1003.1YesYes086
272E:E:M219 T:T:D218 27.82459.7NoYes899
273S:S:I781 T:T:F222 1006.28YesYes889
274T:T:D218 T:T:M219 1002.77YesYes899
275E:E:L223 T:T:F222 1007.31NoYes099
276E:E:L223 S:S:F789 1003.65NoYes097
277T:T:L223 T:T:M219 1004.24YesYes899
278R:R:L796 R:R:L800 32.98182.77NoNo089
279R:R:F804 R:R:L800 33.452610.96NoNo099
280R:R:F804 R:R:W751 33.92338.02NoYes098
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282E:E:I240 E:E:L237 25.11437.14NoNo099
283E:E:L237 S:S:F804 25.87832.44NoNo099
284S:S:F804 S:S:W751 25.82188.02NoYes098
285S:S:W751 T:T:L236 25.84915.69YesYes2189
286S:S:F754 T:T:L236 36.046112.18NoYes2189
287S:S:F754 S:S:I758 35.98476.28NoNo2187
288S:S:F759 S:S:I758 37.49735.02YesNo097
289S:S:F759 S:S:L792 55.91766.09YesNo099
290S:S:F789 S:S:L792 57.79452.44YesNo079
291E:E:L236 R:R:F754 15.83553.65NoYes098
292R:R:M745 R:R:R643 12.72866.2YesYes078
293R:R:M745 R:R:N805 18.85342.8YesNo078
294R:R:H748 R:R:N805 19.321119.13NoNo7098
295R:R:H748 R:R:L752 27.33193.86NoNo099
296R:R:L752 R:R:N797 27.80285.49NoNo099
297R:R:L796 R:R:N797 28.27375.49NoNo089
298R:R:E780 T:T:E215 1005.07YesYes889
299R:R:E780 R:R:P779 10011YesNo888
300R:R:F529 R:R:P779 1004.33NoNo088
301R:R:F529 R:R:P697 1002.89NoYes087
302R:R:L692 R:R:P697 1003.28YesYes1277
303R:R:L692 R:R:S690 1004.5YesNo078
304R:R:P691 R:R:S690 1005.34YesNo098
305R:R:P691 R:R:Y468 1004.17YesYes1099
306R:R:I610 R:R:Y468 1006.04NoYes079
307R:R:I610 R:R:Y466 1004.84NoYes076
308R:R:Q469 R:R:Y466 1006.76NoYes096
309R:R:Q469 R:R:V464 1007.16NoNo097
310R:R:P465 R:R:V464 1003.53NoNo097
311R:R:N444 R:R:P465 1003.26NoNo099
312R:R:L425 R:R:N444 10012.36NoNo099
313R:R:I404 R:R:L425 1002.85YesNo079
314R:R:I401 R:R:I404 1002.94YesYes087
315R:R:I401 R:R:L396 1002.85YesYes089
316R:R:L372 R:R:L396 1002.77YesYes089
317R:R:L350 R:R:L372 1002.77YesYes098
318R:R:L348 R:R:L350 1004.15NoYes099
319R:R:L324 R:R:L348 1004.15NoNo099
320R:R:L301 R:R:L324 1004.15NoNo099
321R:R:I303 R:R:L301 1004.28YesNo089
322R:R:I303 R:R:L279 1004.28YesNo088
323R:R:I277 R:R:L279 1004.28YesNo088
324R:R:F255 R:R:I277 1002.51YesYes298
325R:R:F255 R:R:L253 1006.09YesYes299
326R:R:L230 R:R:L253 1004.15YesYes099
327R:R:L206 R:R:L230 1004.15NoYes099
328R:R:L182 R:R:L206 1004.15YesNo089
329R:R:L158 R:R:L182 1004.15YesYes098
330R:R:L134 R:R:L158 1002.77YesYes799
331R:R:L110 R:R:L134 1004.15YesYes799
332R:R:L110 R:R:L86 1002.77YesNo798
333R:R:L86 R:R:L88 1004.15NoYes089
334R:R:I64 R:R:L88 1005.71NoYes069
335R:R:I64 R:R:L62 1005.71NoNo065
336R:R:L62 R:R:P52 1003.28NoNo058
337R:R:C43 R:R:P52 1003.77NoNo088
338R:R:C33 R:R:C43 1007.28NoNo098
339R:R:T544 T:T:L223 1004.42NoYes899
340R:R:T544 R:R:V545 1003.17NoNo098
341R:R:L536 R:R:V545 1004.47YesNo058
342R:R:L535 R:R:L536 1004.15YesYes1095
343R:R:L535 R:R:P691 1003.28YesYes1099
344R:R:L447 R:R:P465 1003.28NoNo079
345R:R:L425 R:R:L447 1005.54NoNo097
346R:R:L324 R:R:L326 1004.15NoYes097
347R:R:I303 R:R:L326 1002.85YesYes087
348R:R:L350 R:R:N353 1005.49YesYes099
349R:R:N353 R:R:T329 1008.77YesNo1898
350R:R:L326 R:R:T329 1002.95YesNo1878
351R:R:L372 R:R:N375 1004.12YesYes089
352R:R:N353 R:R:N375 1002.72YesYes1899
353R:R:I401 R:R:N423 1009.91YesNo089
354R:R:N399 R:R:N423 1005.45NoNo099
355R:R:N375 R:R:N399 1004.09YesNo1899
356R:R:I331 R:R:N353 1008.5YesYes1889
357R:R:I331 R:R:L326 1004.28YesYes1887
358R:R:F268 R:R:I277 1002.51YesYes298
359R:R:F268 R:R:L253 1003.65YesYes299
360R:R:L110 R:R:L112 1005.54YesYes099
361R:R:L112 R:R:L88 1004.15YesYes099
362R:R:L134 R:R:L136 10011.07YesNo099
363R:R:L112 R:R:L136 1004.15YesNo099
364R:R:I64 R:R:N67 1009.91NoYes069
365R:R:L48 R:R:N67 1005.49NoYes089
366R:R:K46 R:R:L48 1009.87NoNo048
367R:R:C33 R:R:K46 1004.85NoNo094
368R:R:L88 R:R:N91 1006.87YesNo099
369R:R:N67 R:R:N91 1006.81YesNo6099
370R:R:C33 R:R:V41 1003.42NoYes097
371R:R:D137 R:R:Q113 1003.92YesYes199
372R:R:A89 R:R:Q113 90.63476.06NoYes099
373R:R:A89 R:R:S65 81.57043.42NoNo099
374R:R:S44 R:R:S65 45.31833.26YesNo4279
375R:R:D42 R:R:S44 18.12527.36NoYes4297
376R:R:D63 R:R:S65 27.18784.42YesNo4299
377R:R:D42 R:R:D63 54.3796.65NoYes4299
378R:R:Q113 R:R:T111 45.3137.09YesNo199
379R:R:Q87 R:R:T111 72.51237.09NoNo089
380R:R:D63 R:R:Q87 54.38547.83YesNo098
381R:R:R135 R:R:T111 45.32629.06YesNo199
382R:R:D42 R:R:S34 36.25214.42NoNo094
383R:R:C35 R:R:V41 1003.42NoYes097
384R:R:H157 R:R:S133 1005.58YesNo099
385R:R:S133 R:R:V109 1006.46NoNo098
386R:R:K108 R:R:V109 1003.04NoNo088
387R:R:E84 R:R:K108 1004.05NoNo068
388R:R:E84 R:R:E85 10013.95NoNo068
389R:R:E85 R:R:R40 1005.82NoYes5983
390R:R:D38 R:R:R40 54.37614.29NoYes063
391R:R:Q132 R:R:R156 1008.18NoYes089
392R:R:K108 R:R:Q132 10013.56NoNo088
393R:R:E84 R:R:Q60 10016.57NoNo065
394R:R:Q60 R:R:R39 1003.5NoNo057
395R:R:F58 R:R:R39 10013.9NoNo067
396R:R:A61 R:R:E85 54.3764.53NoNo5948
397R:R:L55 R:R:V41 10010.43NoYes5867
398R:R:T59 R:R:V41 1006.35NoYes5887
399R:R:M66 R:R:S44 18.13183.07NoYes097
400R:R:L88 R:R:L93 1004.15YesNo099
401R:R:I96 R:R:L93 1002.85YesNo099
402R:R:I96 R:R:L72 1007.14YesYes097
403R:R:L72 R:R:P73 1004.93YesNo075
404R:R:A76 R:R:P73 1005.61NoNo045
405R:R:L112 R:R:N115 1002.75YesYes099
406R:R:L93 R:R:N115 1006.87NoYes099
407R:R:L136 R:R:N139 1002.75NoYes099
408R:R:N115 R:R:N139 1005.45YesYes6299
409R:R:F255 R:R:N258 1006.04YesYes299
410R:R:L237 R:R:N258 1004.12YesYes289
411R:R:I213 R:R:L237 1002.85YesYes298
412R:R:I213 R:R:N211 1007.08YesYes299
413R:R:N187 R:R:N211 1002.72NoYes099
414R:R:N163 R:R:N187 1004.09NoNo099
415R:R:I141 R:R:N163 10011.33YesNo099
416R:R:I141 R:R:N139 1002.83YesYes099
417R:R:L237 R:R:N235 1002.75YesYes289
418R:R:N211 R:R:N235 1005.45YesYes299
419R:R:L165 R:R:N187 1006.87NoNo099
420R:R:I141 R:R:L165 1002.85YesNo099
421R:R:F80 R:R:L62 1003.65YesNo075
422R:R:F77 R:R:F80 1003.22NoYes077
423R:R:F77 R:R:V51 1003.93NoNo075
424R:R:F77 R:R:L72 1007.31NoYes077
425R:R:I69 R:R:N91 83.70568.5NoNo6079
426R:R:F149 R:R:L158 1003.65YesYes799
427R:R:F149 R:R:S148 10011.89YesNo798
428R:R:P145 R:R:S148 1003.56YesNo798
429R:R:P145 R:R:S122 1005.34YesNo795
430R:R:E123 R:R:S122 1002.87NoNo055
431R:R:E123 R:R:P98 1003.14NoNo054
432R:R:H97 R:R:P98 10012.2YesNo084
433R:R:F95 R:R:H97 1006.79NoYes038
434R:R:F95 R:R:Q71 83.70933.51NoNo034
435R:R:A100 R:R:L72 1003.15NoYes087
436R:R:E74 R:R:H97 83.709229.54NoYes3858
437R:R:D75 R:R:E74 55.806112.99YesNo3845
438R:R:H97 R:R:K99 1005.24YesYes3883
439R:R:D75 R:R:K99 55.80614.15YesYes3843
440R:R:K99 R:R:S102 27.90317.65YesNo3835
441R:R:F80 R:R:N79 83.706110.87YesNo074
442R:R:F80 R:R:L83 1003.65YesNo079
443R:R:A57 R:R:F80 1001.39NoYes047
444R:R:A57 R:R:F82 1001.39NoNo045
445R:R:L104 R:R:L83 1002.77NoNo099
446R:R:L104 R:R:P81 83.70611.64NoNo095
447R:R:F82 R:R:P81 83.70615.78NoNo055
448R:R:L107 R:R:L110 27.90182.77NoYes799
449R:R:H140 R:R:Q116 27.19236.18NoNo086
450R:R:I96 R:R:L101 1004.28YesNo6197
451R:R:A124 R:R:I96 1004.87NoYes6189
452R:R:L131 R:R:L134 83.70492.77YesYes799
453R:R:L117 R:R:N139 83.70339.61NoYes6289
454R:R:P145 R:R:T119 1001.75YesNo095
455R:R:S143 R:R:T119 1004.8NoNo035
456R:R:I125 R:R:L134 83.7062.85NoYes059
457R:R:I125 R:R:P121 27.90223.39NoNo058
458R:R:F149 R:R:V120 83.71042.62YesYes097
459R:R:P121 R:R:V120 27.90233.53NoYes087
460R:R:V120 R:R:V144 27.92256.41YesYes079
461R:R:S148 R:R:V144 27.90683.23NoYes789
462R:R:D147 R:R:P145 83.70743.22NoYes739
463R:R:E123 R:R:R126 27.90235.82NoNo054
464R:R:D147 R:R:E150 55.80453.9NoNo034
465R:R:E150 R:R:R126 27.90326.98NoNo044
466R:R:I125 R:R:L152 27.90192.85NoNo058
467R:R:L131 R:R:L152 27.90312.77YesNo098
468R:R:L128 R:R:L131 27.90252.77NoYes099
469R:R:S143 R:R:T142 1003.2NoNo036
470R:R:F240 R:R:F255 1006.43YesYes299
471R:R:F240 R:R:P241 1008.67YesYes299
472R:R:L216 R:R:P241 1003.28YesYes269
473R:R:I192 R:R:L216 1002.85YesYes286
474R:R:I192 R:R:P193 1003.39YesNo089
475R:R:P193 R:R:V168 1003.53NoYes098
476R:R:P169 R:R:V168 1003.53NoYes098
477R:R:P169 R:R:P172 1005.84NoYes099
478R:R:F240 R:R:F268 1003.22YesYes299
479R:R:L216 R:R:L237 1002.77YesYes268
480R:R:I192 R:R:I213 1002.94YesYes289
481R:R:F197 R:R:I192 1003.77YesYes098
482R:R:F197 R:R:V168 1003.93YesYes098
483R:R:F197 R:R:L182 1003.65YesYes098
484R:R:I189 R:R:N211 1007.08NoYes099
485R:R:I189 R:R:V168 1003.07NoYes098
486R:R:E146 R:R:P172 1003.14NoYes749
487R:R:H171 R:R:P172 1004.58YesYes719
488R:R:F149 R:R:L176 1006.09YesYes099
489R:R:H171 R:R:N175 1003.83YesNo714
490R:R:L155 R:R:L176 27.90225.54NoYes099
491R:R:Q154 R:R:R156 54.37683.5NoYes089
492R:R:Q154 R:R:V153 27.18842.87NoNo083
493R:R:L158 R:R:L160 27.91492.77YesNo099
494R:R:L182 R:R:L184 55.81444.15YesYes089
495R:R:L160 R:R:L184 97.66624.15NoYes099
496R:R:L206 R:R:L208 83.71329.69NoYes099
497R:R:L184 R:R:L208 1004.15YesYes099
498R:R:L230 R:R:L232 1004.15YesNo099
499R:R:L208 R:R:L232 83.70662.77YesNo099
500R:R:I213 R:R:L208 41.8762.85YesYes299
501R:R:A185 R:R:D161 90.63064.63NoYes099
502R:R:S164 R:R:T142 1001.6NoNo056
503R:R:K188 R:R:S164 83.70934.59NoNo045
504R:R:K188 R:R:T166 27.90314.5NoNo046
505R:R:F197 R:R:L200 1004.87YesNo099
506R:R:L173 R:R:L200 83.70362.77NoNo099
507R:R:H171 R:R:S174 1006.97YesNo715
508R:R:L179 R:R:L200 83.70665.54NoNo099
509R:R:L176 R:R:P177 83.70861.64YesNo094
510R:R:N199 R:R:P177 27.90294.89NoNo094
511R:R:A185 R:R:H209 72.5065.85NoYes099
512R:R:K188 R:R:K212 27.90312.87NoNo045
513R:R:C220 R:R:L216 1004.76YesYes256
514R:R:F221 R:R:L230 1006.09YesYes099
515R:R:C220 R:R:F221 10011.17YesYes059
516R:R:I277 R:R:L274 1008.56YesYes289
517R:R:L250 R:R:L274 1004.15NoYes299
518R:R:L247 R:R:L250 1005.54NoNo099
519R:R:F221 R:R:L247 1003.65YesNo099
520R:R:A196 R:R:P193 1003.74NoNo099
521R:R:A196 R:R:F197 1002.77NoYes099
522R:R:C220 R:R:S217 1001.72YesNo056
523R:R:D194 R:R:S217 10011.78NoNo086
524R:R:D194 R:R:H219 1002.52NoYes085
525R:R:F195 R:R:H219 1007.92NoYes6325
526R:R:F195 R:R:T198 83.70393.89NoNo024
527R:R:D222 R:R:H219 10013.87NoYes6345
528R:R:F221 R:R:L224 1003.65YesNo099
529R:R:L203 R:R:L224 83.7064.15NoNo099
530R:R:L203 R:R:L227 41.8532.77NoNo099
531R:R:E228 R:R:V204 1005.7NoYes099
532R:R:D231 R:R:H207 18.130415.13YesYes199
533R:R:D231 R:R:H209 27.18982.52YesYes199
534R:R:H209 R:R:N233 54.38185.1YesYes199
535R:R:N210 R:R:Y234 45.314711.63YesNo196
536R:R:H219 R:R:Q218 83.703913.6YesNo053
537R:R:A246 R:R:D222 83.70393.09NoNo054
538R:R:L247 R:R:P248 27.90591.64NoNo094
539R:R:D225 R:R:P248 13.95293.22NoNo044
540R:R:H256 R:R:Y234 27.18726.53YesNo196
541R:R:F255 R:R:I260 83.70862.51YesYes299
542R:R:F240 R:R:I263 27.90542.51YesNo299
543R:R:F240 R:R:P264 27.9058.67YesNo299
544R:R:A267 R:R:F240 27.9054.16NoYes299
545R:R:I244 R:R:L253 27.9245.71NoYes089
546R:R:F268 R:R:N271 1003.62YesYes299
547R:R:I244 R:R:N271 27.9362.83NoYes089
548R:R:L274 R:R:N271 1004.12YesYes299
549R:R:K251 R:R:R275 90.62953.71YesNo095
550R:R:H256 R:R:Y280 18.130627.22YesNo097
551R:R:N258 R:R:N282 55.85018.17YesYes299
552R:R:I260 R:R:N282 55.80634.25YesYes299
553R:R:I260 R:R:L284 13.95312.85YesNo298
554R:R:I303 R:R:V287 1003.07YesNo089
555R:R:G288 R:R:V287 69.77661.84NoNo099
556R:R:D265 R:R:G288 13.95535.03NoNo089
557R:R:N271 R:R:P272 1001.63YesNo098
558R:R:L273 R:R:P272 27.90484.93NoNo068
559R:R:R275 R:R:T276 36.25185.17NoNo058
560R:R:D297 R:R:R275 36.251811.91NoNo055
561R:R:H278 R:R:T276 18.12595.48NoNo088
562R:R:F286 R:R:G288 41.8666.02NoNo049
563R:R:F286 R:R:S285 27.91071.32NoNo048
564R:R:M308 R:R:S285 13.95533.07NoNo048
565R:R:N294 R:R:P272 1001.63NoNo068
566R:R:H293 R:R:N294 1002.55YesNo076
567R:R:H293 R:R:N314 83.71428.93YesNo6477
568R:R:N289 R:R:N314 55.80956.81NoNo047
569R:R:N289 R:R:Q311 27.904810.56NoNo044
570R:R:H293 R:R:S290 27.90485.58YesNo078
571R:R:L462 R:R:V464 1004.47NoNo077
572R:R:F473 R:R:L462 1003.65YesNo087
573R:R:F456 R:R:F473 1004.29YesYes058
574R:R:F456 R:R:L433 88.55124.87YesYes059
575R:R:L418 R:R:L433 42.39232.77YesYes2399
576R:R:I415 R:R:L418 80.19962.85YesYes2379
577R:R:I415 R:R:L391 1002.85YesYes079
578R:R:I370 R:R:L391 74.69952.85YesYes079
579R:R:I370 R:R:L367 91.94295.71YesNo077
580R:R:L345 R:R:L367 1004.15NoNo097
581R:R:L321 R:R:L345 41.91682.77NoNo3289
582R:R:L321 R:R:T318 31.46174.42NoYes3288
583R:R:L295 R:R:T318 10.54582.95NoYes3298
584R:R:L441 R:R:N444 87.16462.75NoNo089
585R:R:L439 R:R:L441 83.72066.92YesNo2388
586R:R:L418 R:R:L439 42.22314.15YesYes2398
587R:R:L433 R:R:L436 40.9715.54YesYes2398
588R:R:I415 R:R:L436 1002.85YesYes2378
589R:R:F456 R:R:L459 41.84237.31YesNo057
590R:R:L436 R:R:L459 41.0452.77YesNo087
591R:R:L436 R:R:L439 40.97034.15YesYes2388
592R:R:I370 R:R:L372 30.68294.28YesYes078
593R:R:L388 R:R:L391 1006.92YesYes089
594R:R:L367 R:R:L388 65.88752.77NoYes078
595R:R:H293 R:R:T316 27.90472.74YesNo6475
596R:R:L298 R:R:T318 10.46092.95NoYes3298
597R:R:D297 R:R:S296 18.12592.94NoNo059
598R:R:K440 R:R:Q438 10010.85YesYes3089
599R:R:D419 R:R:K440 10020.74NoYes098
600R:R:D419 R:R:S421 1005.89NoNo097
601R:R:F422 R:R:S421 10010.57YesNo4347
602R:R:F422 R:R:R398 1009.62YesNo045
603R:R:R374 R:R:R398 1008.53NoNo085
604R:R:R374 R:R:Y352 95.407119.55NoNo087
605R:R:S351 R:R:Y352 90.8648.9NoNo097
606R:R:S351 R:R:T327 59.06164.8NoYes3199
607R:R:R304 R:R:T327 22.716114.23NoYes3189
608R:R:R304 R:R:V302 18.17295.23NoNo3187
609R:R:S300 R:R:V302 68.14823.23NoNo097
610R:R:T325 R:R:T327 22.71613.14YesYes3189
611R:R:T325 R:R:V302 72.69139.52YesNo3187
612R:R:D349 R:R:S351 27.25922.94YesNo3189
613R:R:D349 R:R:T325 68.1487.23YesYes3188
614R:R:Q373 R:R:R374 36.34569.35NoNo088
615R:R:Q373 R:R:S371 63.60485.78NoNo086
616R:R:D349 R:R:S371 54.51854.42YesNo086
617R:R:R398 R:R:S397 40.88873.95NoNo058
618R:R:Q373 R:R:S397 36.34565.78NoNo088
619R:R:S300 R:R:S323 45.43213.26NoNo097
620R:R:F312 R:R:I331 10.4622.51YesYes1888
621R:R:L345 R:R:Q342 94.2213.99NoYes3298
622R:R:L315 R:R:Q342 10.57832.66NoYes098
623R:R:E341 R:R:Q342 62.79686.37NoYes058
624R:R:E341 R:R:V319 41.86462.85NoNo054
625R:R:H320 R:R:V319 20.93234.15NoNo074
626R:R:H320 R:R:M344 10.46626.57NoNo074
627R:R:N417 R:R:Q438 49.973517.17NoYes3079
628R:R:I393 R:R:N417 45.43092.83NoNo047
629R:R:E369 R:R:I393 36.3472.73NoNo074
630R:R:E368 R:R:E369 31.803710.15NoNo077
631R:R:E368 R:R:R346 13.63026.98NoNo077
632R:R:S323 R:R:T347 22.71614.8NoNo076
633R:R:L338 R:R:Q342 10.46623.99NoYes058
634R:R:G387 R:R:L388 48.76311.71NoYes058
635R:R:G387 R:R:H365 31.03123.18NoNo053
636R:R:G363 R:R:H365 22.16524.77YesNo043
637R:R:E341 R:R:Q340 10.46625.1NoNo054
638R:R:E368 R:R:R392 13.63028.14NoNo076
639R:R:I404 R:R:P429 12.50426.77YesNo079
640R:R:P429 R:R:S406 10.7181.78NoNo093
641R:R:G387 R:R:T411 13.29921.82NoNo054
642T:T:T78 T:T:V64 45.68353.17YesYes099
643R:R:N437 T:T:T78 54.68922.92NoYes059
644R:R:N437 T:T:Y77 41.04576.98NoYes6756
645R:R:N458 T:T:Y77 34.10885.81NoYes046
646R:R:K440 R:R:S463 27.26033.06YesNo3088
647R:R:N458 R:R:V457 20.46532.96NoNo044
648R:R:P524 R:R:S463 18.17363.56NoNo3098
649R:R:E613 R:R:P691 13.9433.14YesYes1099
650R:R:C522 R:R:P524 13.63021.88NoNo099
651R:R:I548 R:R:V545 86.92073.07NoNo078
652R:R:I548 R:R:P791 73.26455.08NoYes079
653R:R:C795 R:R:I548 13.04613.27NoNo097
654R:R:C795 R:R:V551 11.0481.71NoYes096
655R:R:M587 R:R:P791 20.68033.35YesYes6869
656R:R:A794 R:R:M587 10.69033.22NoYes086
657R:R:A794 R:R:N584 10.02133.13NoYes089
658R:R:F790 R:R:P791 48.58734.33NoYes6859
659R:R:F696 R:R:P695 11.66225.78NoYes1279
660R:R:F790 R:R:S629 47.93665.28NoNo058
661R:R:E630 R:R:S629 47.27235.75YesNo088
662R:R:E630 R:R:F634 24.6378.16YesYes987
663R:R:E630 R:R:N714 20.64019.2YesYes989
664R:R:F634 R:R:I633 19.39172.51YesYes976
665R:R:I633 R:R:N714 19.31175.66YesYes969
666R:R:F718 R:R:I633 33.39512.51YesYes966
667R:R:F718 R:R:M721 28.10594.98YesNo967
668R:R:M721 R:R:T640 10.65087.53NoNo977
669R:R:I753 R:R:M721 16.13110.2NoNo997
670S:S:D225 S:S:N226 1002.69NoNo048
671S:S:D225 S:S:P248 10012.88NoNo044
672S:S:L247 S:S:P248 1001.64YesNo094
673S:S:F221 S:S:L247 1003.65NoYes099
674S:S:F221 S:S:L230 1004.87NoNo099
675S:S:L206 S:S:L230 1004.15YesNo099
676S:S:L182 S:S:L206 1004.15YesYes089
677S:S:L158 S:S:L182 1004.15NoYes098
678S:S:L134 S:S:L158 1004.15YesNo099
679S:S:L110 S:S:L134 1004.15YesYes099
680S:S:L110 S:S:L86 1004.15YesYes098
681S:S:L62 S:S:L86 1004.15NoYes058
682S:S:I64 S:S:L62 1008.56YesNo065
683S:S:C43 S:S:I64 1003.27NoYes2586
684S:S:C33 S:S:C43 1007.28NoNo2598
685S:S:L227 S:S:L247 1005.54NoYes099
686S:S:L203 S:S:L227 1002.77YesNo7499
687S:S:L203 S:S:L206 1002.77YesYes099
688S:S:L86 S:S:L88 1005.54YesNo089
689S:S:I64 S:S:L88 1004.28YesNo069
690S:S:L110 S:S:L112 1006.92YesNo099
691S:S:L112 S:S:L88 1004.15NoNo099
692S:S:L134 S:S:L136 1006.92YesYes099
693S:S:L112 S:S:L136 1004.15NoYes099
694S:S:L182 S:S:L184 1006.92YesYes089
695S:S:L160 S:S:L184 1004.15NoYes099
696S:S:L136 S:S:L160 1004.15YesNo099
697S:S:L206 S:S:L208 1005.54YesYes099
698S:S:L184 S:S:L208 1004.15YesYes099
699S:S:I64 S:S:P52 1003.39YesYes2568
700S:S:C33 S:S:P52 1003.77NoYes2598
701S:S:F77 S:S:L86 1004.87YesYes078
702S:S:F77 S:S:V51 1005.24YesNo075
703S:S:P52 S:S:V51 66.97723.53YesNo085
704S:S:R135 S:S:T111 32.22857.76YesNo099
705S:S:Q87 S:S:T111 30.81757.09NoNo089
706S:S:E85 S:S:Q87 19.57213.82YesNo088
707S:S:F77 S:S:F80 1006.43YesYes077
708S:S:F80 S:S:L55 66.98092.44YesNo076
709S:S:L55 S:S:V41 33.490511.92NoNo7367
710S:S:L55 S:S:T59 16.74528.84NoNo7368
711S:S:L48 S:S:P52 1003.28NoYes088
712S:S:K46 S:S:L48 1002.82NoNo048
713S:S:I64 S:S:N67 1007.08YesYes2569
714S:S:L48 S:S:N67 1009.61NoYes089
715S:S:A76 S:S:V51 16.74553.39NoNo045
716S:S:I64 S:S:N91 1004.25YesNo2569
717S:S:I69 S:S:N67 1002.83NoYes2579
718S:S:I69 S:S:N91 1008.5NoNo2579
719S:S:L200 S:S:L203 1005.54NoYes099
720S:S:L179 S:S:L200 1005.54NoNo099
721S:S:L176 S:S:L179 1006.92YesNo099
722S:S:F149 S:S:L176 1003.65YesYes099
723S:S:F149 S:S:S148 10010.57YesNo098
724S:S:P145 S:S:S148 1003.56YesNo1398
725S:S:P145 S:S:S122 10010.69YesNo095
726S:S:D147 S:S:S122 1004.42NoNo035
727S:S:D147 S:S:E123 1003.9NoNo035
728S:S:E123 S:S:P98 1001.57NoNo054
729S:S:H97 S:S:P98 10012.2YesNo084
730S:S:F95 S:S:H97 33.56355.66NoYes038
731S:S:F95 S:S:Q71 16.78187.03NoNo034
732S:S:F77 S:S:L72 1004.87YesNo077
733S:S:L72 S:S:P73 16.74513.28NoNo075
734S:S:I96 S:S:L72 66.98098.56YesNo097
735S:S:E74 S:S:H97 16.781725.85NoYes4558
736S:S:H97 S:S:K99 67.12665.24YesYes4583
737S:S:F80 S:S:N79 16.745221.75YesNo074
738S:S:F80 S:S:P81 1001.44YesNo075
739S:S:F82 S:S:P81 50.23574.33NoNo055
740S:S:E106 S:S:F82 16.74527NoNo075
741S:S:L104 S:S:P81 33.49051.64NoNo095
742S:S:L104 S:S:L83 16.74524.15NoNo099
743S:S:L136 S:S:N139 1004.12YesNo1399
744S:S:L117 S:S:N139 1006.87NoNo089
745S:S:L117 S:S:L93 1002.77NoNo089
746S:S:F149 S:S:V120 58.61152.62YesYes097
747S:S:P121 S:S:V120 33.51293.53NoYes087
748S:S:L117 S:S:P121 25.10623.28NoNo088
749S:S:L93 S:S:N115 58.60266.87NoNo099
750S:S:I96 S:S:L101 16.74524.28YesNo097
751S:S:A124 S:S:I96 16.74524.87NoYes089
752S:S:K99 S:S:S102 50.34514.59YesNo035
753S:S:L107 S:S:L110 16.74512.77NoYes099
754S:S:L110 S:S:L131 33.49125.54YesNo099
755S:S:L155 S:S:L176 33.4914.15NoYes099
756S:S:L152 S:S:L155 25.11444.15NoNo089
757S:S:L131 S:S:L152 16.7382.77NoNo098
758S:S:P145 S:S:T119 33.56343.5YesNo095
759S:S:S143 S:S:T119 25.17264.8NoNo035
760S:S:I141 S:S:L136 50.23622.85YesYes1399
761S:S:L160 S:S:N163 66.98052.75NoYes099
762S:S:I141 S:S:N163 66.9818.5YesYes1399
763S:S:L184 S:S:N187 1004.12YesNo099
764S:S:N163 S:S:N187 66.98076.81YesNo1399
765S:S:L165 S:S:N187 66.980110.98NoNo1399
766S:S:I141 S:S:L165 33.49142.85YesNo1399
767S:S:L173 S:S:L182 1004.15NoYes098
768S:S:L173 S:S:P169 83.91134.93NoNo099
769S:S:P169 S:S:P172 67.16755.84NoNo099
770S:S:P172 S:S:V144 16.93943.53NoYes099
771S:S:D147 S:S:E150 25.17253.9NoNo034
772S:S:L128 S:S:L131 25.11362.77NoNo099
773S:S:S143 S:S:T142 16.78173.2NoNo036
774S:S:G103 S:S:S102 41.95431.86NoNo085
775S:S:G103 S:S:K105 33.56341.74NoNo083
776S:S:K105 S:S:S129 25.17261.53NoNo034
777S:S:S129 S:S:V153 16.78171.62NoNo043
778S:S:C220 S:S:F221 10011.17YesNo059
779S:S:C220 S:S:I192 50.23763.27YesYes1958
780S:S:F197 S:S:I192 25.15562.51YesYes1998
781S:S:F197 S:S:L200 25.11523.65YesNo099
782S:S:H171 S:S:P172 33.49054.58NoNo019
783S:S:H171 S:S:S174 16.74534.18NoNo015
784S:S:L176 S:S:P177 25.13311.64YesNo094
785S:S:C220 S:S:L216 66.97273.17YesYes1956
786S:S:I213 S:S:L216 41.84974.28YesYes1996
787S:S:I213 S:S:N211 16.74365.66YesYes1999
788S:S:I189 S:S:N211 25.11189.91NoYes099
789S:S:L208 S:S:N211 33.47834.12YesYes1999
790S:S:I189 S:S:L184 33.47882.85NoYes099
791S:S:C220 S:S:S217 83.76191.72YesNo056
792S:S:D194 S:S:S217 75.38578.83NoNo086
793S:S:D194 S:S:F195 33.50483.58NoYes4682
794S:S:D194 S:S:H219 33.50482.52NoYes4685
795S:S:D222 S:S:F195 16.75245.97NoYes4642
796S:S:D222 S:S:H219 16.752416.39NoYes4645
797S:S:A196 S:S:F197 33.50612.77NoYes099
798S:S:N210 S:S:Y234 22.347711.63YesYes096
799S:S:L208 S:S:L232 16.74754.15YesNo099
800S:S:L216 S:S:P241 16.80624.93YesNo069
801S:S:L247 S:S:L250 1002.77YesYes099
802S:S:L250 S:S:L253 1002.77YesYes099
803S:S:F255 S:S:L253 1007.31YesYes099
804S:S:F255 S:S:N258 50.31913.62YesYes1499
805S:S:H256 S:S:Y234 15.34264.36YesYes4796
806S:S:F240 S:S:F255 33.51597.5YesYes099
807S:S:F268 S:S:L253 42.78593.65YesYes099
808S:S:F240 S:S:F268 1004.29YesYes099
809S:S:L250 S:S:N271 1004.12YesYes1499
810S:S:F268 S:S:N271 41.8813.62YesYes1499
811S:S:L250 S:S:L274 1002.77YesYes1499
812S:S:F268 S:S:L274 42.12143.65YesYes1499
813S:S:F240 S:S:P264 66.9665.78YesNo099
814S:S:A267 S:S:F240 33.4832.77NoYes099
815S:S:H256 S:S:H278 11.16023.58YesNo098
816S:S:K251 S:S:R275 50.23926.19YesYes095
817S:S:F255 S:S:I260 41.85985.02YesNo1499
818S:S:I277 S:S:L274 1002.85YesYes1489
819S:S:N258 S:S:N282 33.49442.72YesYes1499
820S:S:I260 S:S:N282 33.48737.08NoYes1499
821S:S:N282 S:S:P283 33.49091.63YesNo099
822S:S:P283 S:S:S259 16.74543.56NoNo096
823S:S:F292 S:S:I277 1002.51YesYes098
824S:S:F292 S:S:V287 1002.62YesYes099
825S:S:G288 S:S:V287 58.63473.68NoYes099
826S:S:F286 S:S:G288 50.25846.02NoNo049
827S:S:F286 S:S:V262 16.75282.62NoNo045
828S:S:I263 S:S:P264 33.4833.39NoNo099
829S:S:G270 S:S:N271 92.15181.7NoYes069
830S:S:D269 S:S:G270 83.77441.68NoNo036
831S:S:D269 S:S:G266 75.3975.03NoNo034
832S:S:D265 S:S:G266 67.01963.35NoNo084
833S:S:D265 S:S:S290 58.64227.36NoNo088
834S:S:L274 S:S:L295 1004.15YesNo099
835S:S:D297 S:S:R275 19.531115.48NoYes055
836S:S:L284 S:S:N282 16.74542.75NoYes089
837S:S:F286 S:S:M308 25.12922.49NoNo044
838S:S:F292 S:S:L301 1007.31YesNo099
839S:S:V287 S:S:V309 1003.21YesYes097
840S:S:N289 S:S:S290 16.75495.96NoNo7548
841S:S:N314 S:S:S290 33.50985.96NoNo7578
842S:S:N314 S:S:T316 25.132410.24NoNo075
843S:S:H293 S:S:T316 16.7552.74NoNo075
844S:S:L295 S:S:L298 1005.54NoNo099
845S:S:L295 S:S:T318 1002.95NoNo098
846S:S:L298 S:S:L321 1002.77NoNo098
847S:S:L321 S:S:T318 1004.42NoNo088
848S:S:H299 S:S:R275 29.29662.26NoYes075
849S:S:H299 S:S:H320 19.53113.58NoNo077
850S:S:E368 S:S:R392 18.35646.98NoYes076
851S:S:E368 S:S:R346 13.76746.98NoNo077
852S:S:L301 S:S:L324 1004.15NoNo099
853S:S:T329 S:S:V309 1004.76YesYes3487
854S:S:G328 S:S:T329 1003.64NoYes078
855S:S:G328 S:S:T327 1003.64NoYes079
856S:S:R304 S:S:T327 16.748814.23NoYes4889
857S:S:T325 S:S:T327 33.49723.14YesYes4889
858S:S:I331 S:S:V309 1003.07YesYes3487
859S:S:L321 S:S:Q342 1009.32NoYes088
860S:S:L345 S:S:Q342 1005.32NoYes098
861S:S:L345 S:S:L367 1005.54NoNo097
862S:S:I370 S:S:L367 1005.71YesNo077
863S:S:I370 S:S:L394 1002.85YesYes077
864S:S:F385 S:S:L394 1009.74NoYes097
865S:S:F385 S:S:T384 1006.49NoNo098
866S:S:K381 S:S:T384 1003NoNo018
867S:S:K381 S:S:Q379 1008.14NoNo015
868S:S:Q379 S:S:Y378 10011.27NoNo051
869S:S:R356 S:S:Y378 10010.29NoNo031
870S:S:Q376 S:S:R356 83.81081.17NoNo043
871S:S:N354 S:S:Q376 67.04877.92NoNo034
872S:S:K330 S:S:N354 33.52442.8NoNo053
873S:S:K330 S:S:Q310 16.76224.07NoNo055
874S:S:F312 S:S:I331 33.4962.51NoYes088
875S:S:L324 S:S:L326 75.80215.54NoYes097
876S:S:F312 S:S:P335 25.121711.56NoNo088
877S:S:L315 S:S:Q342 16.74652.66NoYes098
878S:S:L324 S:S:L348 75.80134.15NoNo099
879S:S:D349 S:S:T325 16.74927.23NoYes088
880S:S:S351 S:S:T327 1004.8YesYes099
881S:S:D349 S:S:S351 16.7492.94NoYes089
882S:S:L326 S:S:L350 59.06892.77YesYes079
883S:S:L348 S:S:L350 59.05884.15NoYes099
884S:S:N353 S:S:T329 1008.77YesYes3498
885S:S:I331 S:S:N353 1008.5YesYes3489
886S:S:I334 S:S:L350 50.25184.28NoYes079
887S:S:I334 S:S:P359 33.50456.77NoYes079
888S:S:N337 S:S:P335 16.74996.52NoNo038
889S:S:L367 S:S:L388 1006.92NoNo078
890S:S:G387 S:S:L388 1001.71NoNo058
891S:S:G387 S:S:H365 1003.18NoNo053
892S:S:G363 S:S:H365 50.24283.18NoNo043
893S:S:C339 S:S:G363 16.74761.96NoNo7694
894S:S:C364 S:S:G363 16.74761.96NoNo7694
895S:S:E341 S:S:Q342 33.4933.82NoYes058
896S:S:D349 S:S:S371 16.7494.42NoNo086
897S:S:Q373 S:S:S351 1002.89YesYes089
898S:S:L350 S:S:L372 51.19872.77YesYes098
899S:S:S351 S:S:Y352 41.87148.9YesNo097
900S:S:R374 S:S:Y352 33.497423.66NoNo087
901S:S:Q373 S:S:R374 33.49748.18YesNo088
902S:S:I355 S:S:N353 1004.25NoYes3489
903S:S:N353 S:S:N375 16.74712.72YesNo3499
904S:S:I355 S:S:I377 1002.94NoNo087
905S:S:D357 S:S:R356 16.76223.57NoNo033
906S:S:L358 S:S:L372 16.74974.15NoYes088
907S:S:F361 S:S:I370 16.75722.51NoYes067
908S:S:I377 S:S:N399 1009.91NoNo079
909S:S:I401 S:S:N399 1002.83YesNo1589
910S:S:I401 S:S:I404 1002.94YesNo1587
911S:S:I404 S:S:P429 1006.77NoNo079
912S:S:P429 S:S:S406 1001.78NoYes093
913S:S:H405 S:S:S406 1002.79NoYes4063
914S:S:E382 S:S:H405 10012.31NoNo046
915S:S:E382 S:S:G383 1004.91NoNo044
916S:S:G383 S:S:Q386 1001.64NoNo044
917S:S:N362 S:S:Q386 66.9692.64NoNo044
918S:S:L394 S:S:L418 1004.15YesYes079
919S:S:L418 S:S:L439 1002.77YesYes098
920S:S:F428 S:S:L439 1007.31YesYes1548
921S:S:F428 S:S:P429 1002.89YesNo049
922S:S:N362 S:S:S360 33.48454.47NoNo047
923S:S:H365 S:S:I389 50.240114.58NoNo033
924S:S:I370 S:S:L391 16.76135.71YesNo079
925S:S:L388 S:S:L391 16.75255.54NoNo089
926S:S:L372 S:S:L396 17.20744.15YesNo089
927S:S:D395 S:S:Q373 1005.22NoYes7798
928S:S:Q373 S:S:S397 33.49725.78YesNo7788
929S:S:R374 S:S:R398 50.24618.53NoNo085
930S:S:R398 S:S:S397 25.12292.64NoNo058
931S:S:E403 S:S:Q379 33.52448.92NoNo025
932S:S:I380 S:S:T384 16.76223.04NoNo078
933S:S:G387 S:S:T411 16.74775.46NoNo054
934S:S:D395 S:S:D419 1005.32NoNo099
935S:S:F422 S:S:R398 50.246311.76NoNo045
936S:S:N399 S:S:N423 16.75556.81NoNo1599
937S:S:I401 S:S:L425 33.50222.85YesYes1589
938S:S:L418 S:S:V420 50.23882.98YesNo096
939S:S:L425 S:S:V420 33.47632.98YesNo096
940S:S:E403 S:S:H402 16.762211.08NoNo023
941S:S:R407 S:S:S406 1002.64YesYes4043
942S:S:E431 S:S:S406 1002.87NoYes4033
943S:S:A410 S:S:R407 1002.77NoYes4034
944S:S:A410 S:S:E431 1004.53NoNo4033
945S:S:F409 S:S:L418 50.2866.09NoYes089
946S:S:A408 S:S:F409 16.76212.77NoNo088
947S:S:F409 S:S:L433 16.761810.96NoNo089
948S:S:I415 S:S:L418 50.29224.28NoYes079
949S:S:I415 S:S:L412 16.77098.56NoNo078
950S:S:G413 S:S:I389 33.49411.76NoNo033
951S:S:G413 S:S:P414 16.74794.06NoNo035
952S:S:I415 S:S:L436 16.76455.71NoNo078
953S:S:L436 S:S:L439 16.7652.77NoYes088
954S:S:D419 S:S:S421 16.74875.89NoNo097
955S:S:D419 S:S:K440 10016.59NoNo098
956S:S:F422 S:S:G443 25.12334.52NoNo048
957S:S:L439 S:S:L462 1004.15YesYes087
958S:S:L462 S:S:V464 1004.47YesNo077
959S:S:P465 S:S:V464 1003.53NoNo7997
960S:S:P465 S:S:Y466 1004.17NoNo096
961S:S:K448 S:S:Y466 1007.17NoNo076
962S:S:E449 S:S:K448 1001.35NoNo047
963S:S:E449 S:S:S427 83.8112.87NoNo044
964S:S:S427 S:S:T426 67.04881.6NoNo044
965S:S:K446 S:S:T426 50.28664.5NoNo034
966S:S:E424 S:S:K446 33.52448.1NoNo033
967S:S:E424 S:S:F445 16.76228.16NoNo031
968S:S:L425 S:S:N444 33.49335.49YesNo1599
969S:S:L439 S:S:L441 50.2616.92YesYes1588
970S:S:L441 S:S:N444 16.73882.75YesNo1589
971S:S:F428 S:S:T430 83.81292.59YesNo045
972S:S:F428 S:S:L451 33.52523.65YesNo047
973S:S:D455 S:S:T430 50.28818.67NoNo045
974S:S:F456 S:S:T430 16.76315.19NoNo055
975S:S:F456 S:S:L451 16.76273.65NoNo057
976S:S:L459 S:S:L462 33.52465.54NoYes077
977S:S:F456 S:S:L459 16.76276.09NoNo057
978S:S:A410 S:S:G432 1001.95NoNo038
979S:S:G432 S:S:N434 1001.7NoNo083
980S:S:N434 S:S:V457 66.96897.39NoNo034
981S:S:K440 S:S:S463 1009.18NoNo088
982S:S:L441 S:S:L447 16.76112.77YesNo1587
983S:S:K448 S:S:T614 16.76224.5NoNo074
984S:S:Q469 S:S:V464 33.52435.73NoNo7997
985S:S:A450 S:S:Q469 16.76223.03NoNo049
986S:S:A452 S:S:D455 16.76276.18NoNo7834
987S:S:D455 S:S:K454 16.76276.91NoNo7845
988S:S:F473 S:S:L462 50.28663.65NoYes087
989S:S:A453 S:S:F473 16.76224.16NoNo048
990S:S:S463 S:S:T523 1007.99NoNo086
991S:S:F789 S:S:V763 81.33321.31YesNo079
992S:S:F760 S:S:V763 53.73581.31YesNo089
993S:S:F760 S:S:N714 47.92916.04YesYes089
994S:S:L710 S:S:N714 38.4732.75NoYes099
995S:S:F706 S:S:L710 38.08892.44YesNo059
996S:S:F706 S:S:P695 30.40365.78YesNo059
997S:S:F696 S:S:P695 30.01924.33NoNo079
998S:S:F696 S:S:P697 16.164411.56NoYes4977
999S:S:P524 S:S:T523 1005.25NoNo096
1000S:S:C522 S:S:P524 1001.88NoNo099
1001S:S:C470 S:S:C522 92.11867.28NoNo099
1002S:S:C470 S:S:T526 75.36995.07NoNo098
1003S:S:C471 S:S:T526 58.62115.07NoNo098
1004S:S:C471 S:S:C532 41.87227.28NoNo3599
1005S:S:F473 S:S:I520 16.76223.77NoNo085
1006S:S:C532 S:S:E533 33.49783.04NoNo3594
1007S:S:E533 S:S:Y534 16.74897.86NoNo3544
1008S:S:F696 S:S:L694 13.47036.09NoYes4977
1009S:S:L692 S:S:L787 14.62672.77NoNo079
1010S:S:L536 S:S:L787 13.85714.15YesNo059
1011S:S:F790 S:S:V763 27.43811.31YesNo059
1012S:S:F759 S:S:P793 17.67857.22YesNo099
1013S:S:N756 S:S:P793 17.3034.89YesNo099
1014S:S:N756 S:S:N797 13.50552.72YesYes099
1015S:S:F790 S:S:M587 18.87846.22YesNo056
1016S:S:A794 S:S:M587 12.09764.83NoNo086
1017S:S:A794 S:S:N584 11.72094.69NoYes089
1018T:T:K239 T:T:L236 11.80262.82YesYes2199
1019S:S:A673 S:S:E630 12.07113.02NoYes8488
1020S:S:A673 S:S:F627 11.32062.77NoYes085
1021S:S:F627 S:S:T674 10.19837.78YesNo053
1022T:T:I205 T:T:V61 11.38393.07NoNo099
1023T:T:P179 T:T:R178 10.34095.76YesYes099
1024T:T:E62 T:T:R204 24.928112.79NoYes099
1025T:T:K197 T:T:N196 17.11912.59NoNo099
1026T:T:K197 T:T:Q198 14.26584.07NoNo099
1027T:T:R149 T:T:W120 18.60082NoYes099
1028T:T:R145 T:T:R149 15.113311.73YesNo099
1029T:T:E130 T:T:Q128 1007.65NoYes069
1030T:T:E130 T:T:P129 1006.29NoNo069
1031T:T:N161 T:T:P129 1006.52NoNo099
1032T:T:A164 T:T:N161 1003.13NoNo099
1033L:L:C96 L:L:G81 18.1261.96NoNo000
1034L:L:A130 L:L:G131 1001.95NoNo000
1035R:R:A243 R:R:C220 83.70391.81NoYes085
1036R:R:N282 R:R:P283 83.74151.63YesNo099
1037R:R:P283 R:R:S259 55.82771.78NoNo096
1038R:R:P177 R:R:T178 27.90291.75NoNo045
1039R:R:G270 R:R:N271 83.71421.7NoYes069
1040R:R:G270 R:R:K245 27.90481.74NoNo065
1041R:R:G238 R:R:L237 13.96121.71NoYes028
1042S:S:C35 S:S:V41 16.74521.71NoNo097
1043R:R:G47 R:R:N67 1001.7NoYes079
1044R:R:G47 R:R:N68 1001.7NoNo079
1045R:R:A196 R:R:V170 1001.7NoNo096
1046R:R:G254 R:R:N233 27.18971.7NoYes079
1047R:R:A306 R:R:V287 27.91071.7NoNo099
1048R:R:G317 R:R:N294 27.90481.7NoNo076
1049R:R:A306 R:R:V309 13.95531.7NoNo097
1050R:R:N434 R:R:V457 13.64351.48NoNo034
1051S:S:G47 S:S:N67 1001.7NoYes079
1052S:S:A196 S:S:V170 16.7531.7NoNo096
1053R:R:D36 R:R:R40 1001.19NoYes053
1054R:R:D36 R:R:G37 54.3761.68NoNo054
1055R:R:D269 R:R:G270 27.90481.68NoNo036
1056S:S:N336 S:S:P359 16.74721.63NoYes019
1057E:E:I189 E:E:N193 18.17381.42NoNo059
1058E:E:K197 E:E:N193 27.26071.4NoNo099
1059S:S:A100 S:S:I96 16.74521.62NoYes089
1060R:R:Q71 R:R:T70 55.80621.42NoNo048
1061R:R:S94 R:R:T70 27.90311.6NoNo058
1062R:R:A78 R:R:D75 55.80611.54NoYes044
1063S:S:A246 S:S:D222 16.75241.54NoNo054
1064L:L:K114 L:L:V115 18.1261.52YesNo000
1065R:R:K343 R:R:V319 10.46621.52NoNo074
1066R:R:N236 R:R:S259 27.91391.49NoNo056
1067S:S:N354 S:S:S332 16.76221.49NoNo034
1068R:R:N68 R:R:T49 1001.46NoNo094
1069M:M:D136 M:M:T138 16.74661.45NoNo000
1070R:R:Q180 R:R:S202 99.68711.44YesNo098
1071S:S:A57 S:S:F82 16.74521.39NoNo045
1072S:S:E341 S:S:K343 16.74651.35NoNo057
1073R:R:F58 R:R:S56 54.3761.32NoNo066
1074L:L:R86 R:R:A138 1004.15YesNo109
1075R:R:D137 R:R:D161 1007.98YesYes199
1076R:R:R135 R:R:W159 10017.99YesYes199
1077R:R:H209 R:R:N210 36.26387.65YesYes199
1078L:L:L59 L:L:Q56 1005.32NoNo000
1079L:L:C55 L:L:C74 1007.28YesYes300
1080E:E:H102 L:L:Q70 1003.71YesNo390
1081E:E:R149 E:E:Y116 54.36553.09NoYes099
1082T:T:L131 T:T:Q128 1003.99YesYes499
1083M:M:L44 M:M:R54 1007.29NoNo000
1084M:M:N50 T:T:P103 14.91756.52YesNo409
1085E:E:P210 E:E:Q212 14.59827.9YesNo098
1086T:T:G119 T:T:Y118 73.5732.9YesYes699
1087E:E:R145 E:E:R149 18.12264.26YesNo5499
1088T:T:E95 T:T:R204 10019.77YesYes089
1089T:T:R204 T:T:V64 27.17986.54YesYes2999
1090E:E:R178 E:E:T152 1006.47YesNo099
1091T:T:E62 T:T:T78 22.64942.82NoYes099
1092E:E:M219 T:T:F222 24.96644.98NoYes899
1093R:R:F754 R:R:I753 14.86786.28YesNo089
1094E:E:L236 R:R:W751 12.95746.83NoYes5798
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:S45 T:T:L131 7.51 4 No Yes 0 9 0 1
M:M:S47 T:T:E127 8.62 4 No Yes 0 9 0 1
M:M:D49 T:T:K125 9.68 4 No Yes 0 9 0 1
M:M:D49 T:T:M192 6.93 4 No Yes 0 9 0 1
M:M:N50 T:T:Q100 3.96 4 Yes No 0 7 0 1
M:M:N50 T:T:H102 10.2 4 Yes Yes 0 9 0 1
M:M:N50 T:T:P103 6.52 4 Yes No 0 9 0 1
M:M:N50 T:T:K125 6.99 4 Yes Yes 0 9 0 1
M:M:N50 T:T:E127 6.57 4 Yes Yes 0 9 0 1
M:M:S53 T:T:H102 5.58 4 No Yes 0 9 0 1
M:M:S53 T:T:L104 3 4 No Yes 0 9 0 1
M:M:R54 T:T:L131 7.29 4 No Yes 0 9 0 1
M:M:K58 S:S:N114 2.8 5 Yes Yes 0 9 0 1
M:M:K58 S:S:A138 3.21 5 Yes No 0 9 0 1
M:M:K58 S:S:H140 2.62 5 Yes No 0 8 0 1
M:M:K58 S:S:D162 15.21 5 Yes No 0 9 0 1
M:M:F61 T:T:L104 6.09 4 Yes Yes 0 9 0 1
M:M:L63 T:T:H102 5.14 0 Yes Yes 0 9 0 1
M:M:R65 T:T:V99 3.92 6 No Yes 0 7 0 1
M:M:R65 T:T:Y116 10.29 6 No Yes 0 9 0 1
M:M:M68 T:T:I98 2.92 53 No No 0 8 0 1
M:M:M68 T:T:V195 4.56 53 No No 0 9 0 1
M:M:M68 T:T:A201 3.22 53 No No 0 9 0 1
M:M:R69 T:T:N196 3.62 11 No No 0 9 0 1
M:M:H76 S:S:G90 3.18 0 No No 0 9 0 1
M:M:H76 S:S:Q113 3.71 0 No Yes 0 9 0 1
M:M:S77 S:S:Q113 4.33 0 No Yes 0 9 0 1
M:M:H85 S:S:H209 3.58 0 No Yes 0 9 0 1
M:M:R86 S:S:Q113 3.5 5 Yes Yes 0 9 0 1
M:M:R86 S:S:D137 5.96 5 Yes Yes 0 9 0 1
M:M:R86 S:S:A138 2.77 5 Yes No 0 9 0 1
M:M:R86 S:S:D161 10.72 5 Yes No 0 9 0 1
M:M:R86 S:S:D162 3.57 5 Yes No 0 9 0 1
M:M:R86 S:S:L186 3.64 5 Yes Yes 0 9 0 1
M:M:P88 S:S:N210 9.77 0 No Yes 0 9 0 1
M:M:D89 T:T:K134 6.91 0 No No 0 9 0 1
M:M:M90 T:T:L104 2.83 4 No Yes 0 9 0 1
M:M:R97 T:T:E112 6.98 0 No No 0 9 0 1
M:M:F105 S:S:W159 13.03 5 Yes Yes 0 9 0 1
M:M:F105 S:S:A181 8.32 5 Yes No 0 9 0 1
M:M:F105 S:S:T183 5.19 5 Yes No 0 9 0 1
M:M:F105 S:S:V205 2.62 5 Yes Yes 0 9 0 1
M:M:S106 S:S:V205 3.23 5 No Yes 0 9 0 1
M:M:S106 S:S:H207 4.18 5 No Yes 0 9 0 1
M:M:K107 T:T:D111 4.15 0 No No 0 9 0 1
M:M:D108 S:S:T229 5.78 0 No No 0 9 0 1
M:M:D108 S:S:E252 5.2 0 No No 0 9 0 1
M:M:F109 S:S:H157 4.53 5 Yes Yes 0 9 0 1
M:M:F109 S:S:Q180 3.51 5 Yes No 0 9 0 1
M:M:F109 S:S:A181 2.77 5 Yes No 0 9 0 1
M:M:F109 S:S:V204 6.55 5 Yes Yes 0 9 0 1
M:M:F109 S:S:V205 6.55 5 Yes Yes 0 9 0 1
M:M:T111 S:S:H157 10.95 0 No Yes 0 9 0 1
M:M:R121 S:S:V204 3.92 0 No Yes 0 9 0 1
M:M:R121 S:S:N226 10.85 0 No No 0 8 0 1
M:M:R123 S:S:K251 4.95 0 No Yes 0 9 0 1
S:S:A89 S:S:Q113 6.06 0 No Yes 9 9 2 1
S:S:G90 S:S:N114 3.39 0 No Yes 9 9 1 1
S:S:N114 S:S:Q113 2.64 5 Yes Yes 9 9 1 1
S:S:Q113 S:S:R135 5.84 5 Yes Yes 9 9 1 2
S:S:D137 S:S:Q113 10.44 5 Yes Yes 9 9 1 1
S:S:A138 S:S:N114 4.69 5 No Yes 9 9 1 1
S:S:H140 S:S:K118 5.24 0 No No 8 4 1 2
S:S:H157 S:S:S133 6.97 5 Yes No 9 9 1 2
S:S:D137 S:S:R135 16.68 5 Yes Yes 9 9 1 2
S:S:R135 S:S:W159 13 5 Yes Yes 9 9 2 1
S:S:D137 S:S:W159 3.35 5 Yes Yes 9 9 1 1
S:S:D137 S:S:D161 11.98 5 Yes No 9 9 1 1
S:S:H157 S:S:R156 10.16 5 Yes No 9 9 1 2
S:S:Q180 S:S:R156 11.68 0 No No 9 9 1 2
S:S:H157 S:S:W159 5.29 5 Yes Yes 9 9 1 1
S:S:A181 S:S:H157 2.93 5 No Yes 9 9 1 1
S:S:D161 S:S:W159 3.35 5 No Yes 9 9 1 1
S:S:D162 S:S:L186 6.79 5 No Yes 9 9 1 1
S:S:Q180 S:S:S202 2.89 0 No No 9 8 1 2
S:S:H207 S:S:T183 9.58 5 Yes No 9 9 1 1
S:S:A185 S:S:L186 3.15 0 No Yes 9 9 2 1
S:S:A185 S:S:H209 4.39 0 No Yes 9 9 2 1
S:S:L186 S:S:N210 4.12 5 Yes Yes 9 9 1 1
S:S:V204 S:S:V205 3.21 5 Yes Yes 9 9 1 1
S:S:E228 S:S:V204 5.7 0 No Yes 9 9 2 1
S:S:H207 S:S:V205 4.15 5 Yes Yes 9 9 1 1
S:S:T229 S:S:V205 9.52 0 No Yes 9 9 1 1
S:S:D231 S:S:H207 11.35 0 No Yes 9 9 2 1
S:S:H209 S:S:N210 3.83 0 Yes Yes 9 9 1 1
S:S:H209 S:S:N233 5.1 0 Yes Yes 9 9 1 2
S:S:N210 S:S:Y234 11.63 0 Yes Yes 9 6 1 2
S:S:D225 S:S:N226 2.69 0 No No 4 8 2 1
S:S:E228 S:S:K251 5.4 0 No Yes 9 9 2 1
S:S:D231 S:S:T229 2.89 0 No No 9 9 2 1
S:S:D231 S:S:N233 4.04 0 No Yes 9 9 2 2
S:S:N233 S:S:Y234 3.49 47 Yes Yes 9 6 2 2
S:S:E252 S:S:K251 2.7 0 No Yes 9 9 1 1
S:S:K251 S:S:R275 6.19 0 Yes Yes 9 5 1 2
T:T:A201 T:T:I98 4.87 53 No No 9 8 1 1
T:T:A203 T:T:I98 3.25 0 No No 9 8 2 1
T:T:M101 T:T:V99 3.04 6 Yes Yes 9 7 2 1
T:T:V99 T:T:Y116 2.52 6 Yes Yes 7 9 1 1
T:T:V99 T:T:W120 12.26 6 Yes Yes 7 9 1 2
T:T:Q100 T:T:V195 2.87 0 No No 7 9 1 1
T:T:M101 T:T:Y116 5.99 6 Yes Yes 9 9 2 1
T:T:M101 T:T:W120 6.98 6 Yes Yes 9 9 2 2
T:T:H102 T:T:P103 10.68 4 Yes No 9 9 1 1
T:T:H102 T:T:L104 7.71 4 Yes Yes 9 9 1 1
T:T:P103 T:T:V124 3.53 4 No No 9 9 1 2
T:T:D114 T:T:Y116 4.6 0 No Yes 9 9 2 1
T:T:W120 T:T:Y116 2.89 6 Yes Yes 9 9 2 1
T:T:M192 T:T:V123 3.04 4 Yes No 9 9 1 2
T:T:D157 T:T:K125 8.3 4 Yes Yes 9 9 2 1
T:T:K125 T:T:M192 4.32 4 Yes Yes 9 9 1 1
T:T:E127 T:T:Q128 5.1 4 Yes Yes 9 9 1 2
T:T:E127 T:T:L131 2.65 4 Yes Yes 9 9 1 1
T:T:L131 T:T:Q128 3.99 4 Yes Yes 9 9 1 2
T:T:D132 T:T:L131 4.07 0 No Yes 9 9 2 1
T:T:D132 T:T:P135 3.22 0 No No 9 9 2 2
T:T:D157 T:T:M192 6.93 4 Yes Yes 9 9 2 1
T:T:K197 T:T:N196 12.59 0 No No 9 9 2 1
S:S:H140 S:S:Q116 2.47 0 No No 8 6 1 2
M:M:L63 T:T:G105 1.71 0 Yes No 0 9 0 1
T:T:K134 T:T:P133 1.67 0 No No 9 9 1 2
T:T:K134 T:T:P135 1.67 0 No No 9 9 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.71Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
80.00Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
71.43Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
68.00Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6D35Cholesterol6D35-SMO-Cholesterol
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.26Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.26Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.26Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.26Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.26Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.26Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.26Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTTCa7DTT-CaS-Ca-Ca
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTUTryptophan7DTU-CaS-Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.26Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.26Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.26Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.26Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.26Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.26Single7XW7K1-707XW7-TSH-K1-70
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.26Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.26Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.26Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.26Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.26Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.26Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.26Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.26Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.26Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8WVXNorrin8WVX-LGR4-Norrin
5.26Single8WVYNorrin8WVY-LGR4-Norrin
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.26Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.26Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.26Single9KHHNorrin9KHH-LGR4-Norrin
5.26Single9S37NB219S37-LGR4-NB21
5.26Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.76Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.76Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.55Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.55Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.55Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
4.55Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.55Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.35Single5L7DCholesterol5L7D-SMO-Cholesterol
4.35Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.35Single8HS2Fab0468HS2-GPR20-Fab046
4.35Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.17Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
4.17Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.17Consensusp2y_offOrthosteric Ligandp2y1_off
4.00Single4XNWMRS25004XNW-P2Y1-MRS2500
4.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.00Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
4.00Single8JPSCCL78JPS-ACKR1-CCL7
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
3.85Single4O9RCyclopamine4O9R-SMO-Cyclopamine
3.85Single6LI0C176LI0-GPR52-C17
3.85Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
3.85Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
3.85Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
3.85Single9B9Y7DY9B9Y-CB1-7DY
3.85Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
3.70Single4BWBNeurotensin4BWB-NTS1-Neurotensin
3.70Single4QINSAG1.54QIN-SMO-SAG1.5
3.70Single5U09Taranabant5U09-CB1-Taranabant
3.70Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
3.70Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
3.70Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
3.70Single7BR3Elagolix7BR3-GnRH1-Elagolix
3.70Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
3.70Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
3.70Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
3.70Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
3.70Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
3.70Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.70Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.70Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
3.70Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
3.70Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.70Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.70Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.70Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
3.70Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.70Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
3.57Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
3.57Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.57Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
3.57Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.57Single7VV6C48/807VV6-MRGPRX2-C48/80
3.57Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.57Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.57Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9BA0A1AKN9BA0-CB1-A1AKN
3.57Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
3.57Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
3.57Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
3.57Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.57Consensusgrh_offOrthosteric Ligandgnrh1_off
3.57Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
3.57Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.45Single4QIMANTA XV4QIM-SMO-ANTA XV
3.45Single5T04Neurotensin5T04-NTS1-Neurotensin
3.45Single5TGZAM65385TGZ-CB1-AM6538
3.45Single6D27CAY104716D27-DP2-CAY10471
3.45Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
3.45Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
3.45Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
3.45Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.45Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
3.45Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
3.45Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
3.45Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.45Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
3.45Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
3.45Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
3.45Single7YXAONO-54306087YXA-S1P5-ONO-5430608
3.45Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.45Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.45Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.45Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
3.45Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
3.45Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
3.33Single4JKVTaladegib4JKV-SMO-Taladegib
3.33Single5C1MBU725C1M-μ-BU72
3.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
3.33Single7C4SS1P7C4S-S1P3-S1P
3.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
3.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
3.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
3.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
3.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
3.33Single9B9ZA1AKO9B9Z-CB1-A1AKO
3.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
3.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
3.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
3.23Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
3.23Single4BV0Neurotensin4BV0-NTS1-Neurotensin
3.23Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
3.23Single5V56TC1145V56-SMO-TC114
3.23Single5V57TC1145V57-SMO-TC114
3.23Single6OS1TRV0266OS1-AT1-TRV026
3.23Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.23Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
3.23Single7F1TMIP-1a7F1T-CCR5-MIP-1a
3.23Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
3.23Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
3.23Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
3.23Single7R0CAVP7R0C-V2-AVP-Arrestin2
3.23Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.23Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.23Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
3.23Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
3.23Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Single8E0GBU728E0G-μ-BU72
3.23Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
3.23Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
3.23Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.23Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
3.23Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
3.23Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
3.23Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.23Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.23Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
3.23Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
3.23Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Consensuslpa_onOrthosteric Ligandlpa1_on
3.23Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
3.23Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusneurotensin_onOrthosteric Ligandnts1_on
3.23Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.23Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.23Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.23Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.12Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.12Single4XEENeurotensin4XEE-NTS1-Neurotensin
3.12Single4XESNeurotensin4XES-NTS1-Neurotensin
3.12Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
3.12Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
3.12Single6OS2TRV0266OS2-AT1-TRV026
3.12Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.12Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.12Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.12Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
3.12Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.12Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.12Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
3.12Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
3.12Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.12Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.12Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
3.12Single8XQJJN2418XQJ-Apelin-JN241
3.12Single8XWACXCL18XWA-CXCR2-CXCL1
3.12Single8XWMCXCL68XWM-CXCR2-CXCL6
3.12Single8XWSCXCL58XWS-CXCR2-CXCL5
3.12Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.12Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
3.12Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
3.12Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.12Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
3.12Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
3.12Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.12Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
3.12Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
3.12Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
3.12Consensuslpa_offOrthosteric Ligandlpa1_off
3.12Consensuslpl_offOrthosteric Ligands1p_off lpa_off
3.12Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
3.12Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
3.12Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.12Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.12Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.12Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.12Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.03Single4BUONeurotensin4BUO-NTS1-Neurotensin
3.03Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.03Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
3.03Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.03Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.03Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
3.03Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
3.03Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.03Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.03Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.03Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
3.03Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
3.03Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.03Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
3.03Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.03Single8XVUCXCL28XVU-CXCR2-CXCL2
3.03Single8XWFCXCL38XWF-CXCR2-CXCL3
3.03Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.03Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.03Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.03Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.03Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.03Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
3.03Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
3.03Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.03Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
2.94Single6KNMJN241-96KNM-Apelin-JN241-9
2.94Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
2.94Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
2.94Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
2.94Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
2.94Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.94Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
2.94Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
2.94Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
2.94Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
2.94Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8QJ2pN1628QJ2-MC4-pN162-Gs
2.94Single8XQJJN2418XQJ-Apelin-JN241
2.94Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
2.94Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.94Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
2.94Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
2.94Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
2.94Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
2.86Single4XT1Fractalkine4XT1-US28-Fractalkine
2.86Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
2.86Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
2.86Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
2.86Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
2.86Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
2.86Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.86Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
2.86Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
2.86Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
2.86Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.86Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
2.86Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
2.86Single8XWNCXCL88XWN-CXCR2-CXCL8
2.86Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.86Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
2.86Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
2.86Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.86Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.86Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
2.86Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
2.86Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.86Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
2.86Consensuslpl_onOrthosteric Ligands1p_on lpa_on
2.86Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
2.86Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.86Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
2.78Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
2.78Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
2.78Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
2.78Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
2.78Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.78Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
2.78Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
2.78Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.78Single7SK5CXCL127SK5-ACKR3-CXCL12
2.78Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
2.78Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
2.78Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
2.78Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.78Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
2.78Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
2.78Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
2.78Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
2.78Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.78Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
2.78Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
2.70Single3OE0CVX153OE0-CXCR4-CVX15
2.70Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
2.70Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
2.70Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
2.70Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
2.70Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.70Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
2.70Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
2.70Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
2.70Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
2.70Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.70Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
2.70Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
2.70Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
2.70Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
2.70Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.70Consensusangiotensin_onOrthosteric Ligandat1_on
2.70Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.70Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.70Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
2.70Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
2.70Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
2.70Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
2.70Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.70Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.70Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.63Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
2.63Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
2.63Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
2.63Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
2.63Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.63Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
2.63Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
2.63Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
2.63Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
2.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.63Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
2.63Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
2.63Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.63Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
2.63Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
2.63Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
2.63Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.63Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
2.63Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.63Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.63Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.63Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.63Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
2.63Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.63Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
2.63Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
2.63Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
2.63Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
2.63Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
2.63Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.63Consensusvasop-oxy_onOrthosteric Ligandv2_on
2.63Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
2.56Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
2.56Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
2.56Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
2.56Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
2.56Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
2.56Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.56Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.56Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
2.56Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
2.56Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.56Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.56Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.56Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
2.56Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
2.56Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
2.56Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
2.56Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
2.56Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
2.56Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.56Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.56Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
2.56Consensuscalcitonin_onOrthosteric Ligandctlike_on
2.56Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
2.56Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
2.56Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
2.56Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
2.56Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.56Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
2.56Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
2.56Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
2.56Consensuspac_onOrthosteric Ligandpac1_on
2.56Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.56Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
2.50Single4XT3Fractalkine4XT3-US28-Fractalkine
2.50Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
2.50Single6FJ3PTH6FJ3-PTH1-PTH
2.50Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.50Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
2.50Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.50Single7SK3CXCL127SK3-ACKR3-CXCL12
2.50Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
2.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.50Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
2.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
2.50Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
2.50Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
2.50Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
2.50Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.50Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
2.50Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
2.50Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
2.50Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
2.50Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.50Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
2.50Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.50Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.50Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.50Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
2.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
2.50Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
2.50Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.50Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.50Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
2.50Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
2.50Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.50Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
2.44Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.44Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
2.44Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.44Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
2.44Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
2.44Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
2.44Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
2.44Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
2.44Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.44Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.44Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
2.44Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
2.44Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.44Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.44Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
2.44Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.44Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
2.44Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
2.44Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
2.44Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.44Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.44Consensusglp_onOrthosteric Ligandglp1_on glp2_on
2.44Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
2.44Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
2.44Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.44Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
2.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.38Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
2.38Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.38Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
2.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.38Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.38Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.38Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.38Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.38Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
2.38Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.38Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
2.38Single8IY6Endothelin-18IY6-ETB-Endothelin-1
2.38Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.38Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
2.38Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
2.38Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.38Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.38Consensusbradykinin_onOrthosteric Ligandbk2_on
2.38Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
2.38Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.38Consensusendothelin_onOrthosteric Ligandetb_on eta_on
2.38Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
2.38Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.38Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
2.38Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
2.38Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.38Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
2.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
2.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.33Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
2.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
2.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.33Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.33Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
2.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
2.27Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
2.27Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.27Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.27Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.27Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.27Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.27Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
2.27Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.27Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
2.27Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
2.27Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
2.27Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.22Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
2.22Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
2.22Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
2.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.22Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.22Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
2.22Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
2.22Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.17Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.17Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.17Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
2.17Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
2.17Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
2.17Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.17Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.17Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.17Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
2.17Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
2.17Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.13Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.13Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.13Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.13Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.08Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.08Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.08Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.04Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.04Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.04Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
1.96Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
1.96Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
1.89Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
1.85Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:L131 L:L:S45 6.01 0 No No 9 0 1 0
E:E:E127 L:L:S47 5.75 3 No No 9 0 1 0
E:E:K125 L:L:D49 12.44 3 Yes Yes 9 0 1 0
E:E:M192 L:L:D49 5.54 3 Yes Yes 9 0 1 0
E:E:H102 L:L:N50 12.75 3 Yes Yes 9 0 1 0
E:E:P103 L:L:N50 6.52 3 No Yes 9 0 1 0
E:E:K125 L:L:N50 5.6 3 Yes Yes 9 0 1 0
E:E:E127 L:L:N50 6.57 3 No Yes 9 0 1 0
E:E:E127 L:L:S53 7.19 3 No No 9 0 1 0
L:L:K58 R:R:N114 4.2 0 Yes No 0 9 0 1
L:L:K58 R:R:H140 7.86 0 Yes No 0 8 0 1
L:L:K58 R:R:D162 4.15 0 Yes No 0 9 0 1
E:E:L104 L:L:F61 4.87 3 No Yes 9 0 1 0
E:E:H102 L:L:L63 6.43 3 Yes Yes 9 0 1 0
E:E:Y116 L:L:R65 13.38 0 Yes No 9 0 1 0
E:E:I98 L:L:M68 7.29 3 No No 8 0 1 0
E:E:V195 L:L:M68 3.04 3 Yes No 9 0 1 0
E:E:A201 L:L:M68 3.22 0 No No 9 0 1 0
E:E:N196 L:L:R69 3.62 0 No No 9 0 1 0
E:E:H102 L:L:Q70 3.71 3 Yes No 9 0 1 0
L:L:H76 R:R:G90 3.18 0 No No 0 9 0 1
L:L:S77 R:R:R135 3.95 0 No Yes 0 9 0 1
L:L:R86 R:R:D137 10.72 1 Yes Yes 0 9 0 1
L:L:R86 R:R:A138 4.15 1 Yes No 0 9 0 1
L:L:R86 R:R:D161 10.72 1 Yes Yes 0 9 0 1
L:L:P88 R:R:L186 3.28 1 No No 0 9 0 1
L:L:P88 R:R:N210 11.4 1 No Yes 0 9 0 1
E:E:L104 L:L:M90 2.83 3 No No 9 0 1 0
E:E:N110 L:L:R92 3.62 0 No No 9 0 1 0
E:E:E112 L:L:R97 13.96 0 No No 9 0 1 0
L:L:F105 R:R:W159 14.03 1 Yes Yes 0 9 0 1
L:L:F105 R:R:A181 8.32 1 Yes No 0 9 0 1
L:L:F105 R:R:T183 3.89 1 Yes Yes 0 9 0 1
L:L:F105 R:R:V205 3.93 1 Yes Yes 0 9 0 1
L:L:S106 R:R:H207 5.58 0 No Yes 0 9 0 1
L:L:F109 R:R:H157 5.66 1 Yes Yes 0 9 0 1
L:L:F109 R:R:Q180 3.51 1 Yes Yes 0 9 0 1
L:L:F109 R:R:V204 6.55 1 Yes Yes 0 9 0 1
L:L:F109 R:R:V205 5.24 1 Yes Yes 0 9 0 1
L:L:T111 R:R:H157 6.85 0 No Yes 0 9 0 1
L:L:R121 R:R:V204 2.62 0 No Yes 0 9 0 1
L:L:R121 R:R:N226 8.44 0 No No 0 8 0 1
L:L:R123 R:R:K251 4.95 0 Yes Yes 0 9 0 1
E:E:I98 E:E:V123 3.07 3 No No 8 9 1 2
E:E:I98 E:E:V195 4.61 3 No Yes 8 9 1 1
E:E:V99 E:E:Y116 2.52 0 No Yes 7 9 2 1
E:E:Q100 E:E:V195 4.3 0 No Yes 7 9 2 1
E:E:M101 E:E:Y116 7.18 0 No Yes 9 9 2 1
E:E:H102 E:E:P103 10.68 3 Yes No 9 9 1 1
E:E:H102 E:E:L104 6.43 3 Yes No 9 9 1 1
E:E:N109 E:E:N110 9.54 0 No No 8 9 2 1
E:E:E113 E:E:N110 7.89 54 No No 9 9 2 1
E:E:D111 E:E:E112 6.5 0 No No 9 9 2 1
E:E:E113 E:E:R149 11.63 54 No No 9 9 2 2
E:E:E117 E:E:Y116 4.49 0 No Yes 9 9 2 1
E:E:R149 E:E:Y116 3.09 54 No Yes 9 9 2 1
E:E:D157 E:E:K125 5.53 3 Yes Yes 9 9 2 1
E:E:K125 E:E:M192 2.88 3 Yes Yes 9 9 1 1
E:E:D157 E:E:M192 4.16 3 Yes Yes 9 9 2 1
E:E:M192 E:E:V195 3.04 3 Yes Yes 9 9 1 1
E:E:K197 E:E:N196 13.99 0 No No 9 9 2 1
R:R:G90 R:R:N114 5.09 0 No No 9 9 1 1
R:R:Q113 R:R:T111 7.09 1 Yes No 9 9 2 2
R:R:R135 R:R:T111 9.06 1 Yes No 9 9 1 2
R:R:Q113 R:R:R135 3.5 1 Yes Yes 9 9 2 1
R:R:D137 R:R:Q113 3.92 1 Yes Yes 9 9 1 2
R:R:A138 R:R:N114 4.69 1 No No 9 9 1 1
R:R:H140 R:R:Q116 6.18 0 No No 8 6 1 2
R:R:H157 R:R:S133 5.58 0 Yes No 9 9 1 2
R:R:D137 R:R:R135 4.76 1 Yes Yes 9 9 1 1
R:R:R135 R:R:W159 17.99 1 Yes Yes 9 9 1 1
R:R:A138 R:R:D137 3.09 1 No Yes 9 9 1 1
R:R:D137 R:R:D161 7.98 1 Yes Yes 9 9 1 1
R:R:H157 R:R:R156 5.64 0 Yes Yes 9 9 1 2
R:R:Q180 R:R:R156 7.01 1 Yes Yes 9 9 1 2
R:R:H157 R:R:W159 3.17 0 Yes Yes 9 9 1 1
R:R:A181 R:R:H157 2.93 0 No Yes 9 9 1 1
R:R:D161 R:R:W159 4.47 1 Yes Yes 9 9 1 1
R:R:T183 R:R:W159 3.64 1 Yes Yes 9 9 1 1
R:R:D161 R:R:T183 7.23 1 Yes Yes 9 9 1 1
R:R:A185 R:R:D161 4.63 0 No Yes 9 9 2 1
R:R:D162 R:R:L186 8.14 0 No No 9 9 1 1
R:R:Q180 R:R:V204 2.87 1 Yes Yes 9 9 1 1
R:R:H207 R:R:T183 5.48 1 Yes Yes 9 9 1 1
R:R:A185 R:R:H209 5.85 0 No Yes 9 9 2 2
R:R:L186 R:R:N210 8.24 1 No Yes 9 9 1 1
R:R:V204 R:R:V205 4.81 1 Yes Yes 9 9 1 1
R:R:E228 R:R:V204 5.7 0 No Yes 9 9 2 1
R:R:H207 R:R:V205 4.15 1 Yes Yes 9 9 1 1
R:R:T229 R:R:V205 7.93 1 Yes Yes 9 9 2 1
R:R:H207 R:R:H209 4.78 1 Yes Yes 9 9 1 2
R:R:H207 R:R:T229 2.74 1 Yes Yes 9 9 1 2
R:R:D231 R:R:H207 15.13 1 Yes Yes 9 9 2 1
R:R:H209 R:R:N210 7.65 1 Yes Yes 9 9 2 1
R:R:D231 R:R:H209 2.52 1 Yes Yes 9 9 2 2
R:R:N210 R:R:Y234 11.63 1 Yes No 9 6 1 2
R:R:E228 R:R:K251 10.8 0 No Yes 9 9 2 1
R:R:D231 R:R:T229 4.34 1 Yes Yes 9 9 2 2
R:R:E252 R:R:T229 4.23 0 No Yes 9 9 2 2
R:R:E252 R:R:K251 6.75 0 No Yes 9 9 2 1
R:R:K251 R:R:R275 3.71 0 Yes No 9 5 1 2
E:E:G105 L:L:L63 1.71 0 No Yes 9 0 1 0
E:E:A201 E:E:I194 1.62 0 No No 9 9 1 2
R:R:Q180 R:R:S202 1.44 1 Yes No 9 8 1 2
E:E:D114 E:E:L115 1.36 0 No No 9 8 1 2
E:E:L131 E:E:Q128 1.33 0 No No 9 9 1 2
E:E:L131 L:L:R54 1.21 0 No No 9 0 1 0
E:E:D114 L:L:R65 1.19 0 No No 9 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
71.43Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
68.18Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
66.67Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
54.55Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.88Single6D35Cholesterol6D35-SMO-Cholesterol
5.88Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.88Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.88Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.88Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.88Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.88Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.88Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.88Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.88Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.88Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.88Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.88Single7DTTCa7DTT-CaS-Ca-Ca
5.88Single7DTTCa7DTT-CaS-Ca-Ca
5.88Single7DTUTryptophan7DTU-CaS-Tryptophan
5.88Single7DTUTryptophan7DTU-CaS-Tryptophan
5.88Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.88Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.88Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.88Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.88Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.88Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.88Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.88Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.88Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.88Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.88Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.88Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.88Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.88Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.88Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.88Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.88Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.88Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.88Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.88Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.88Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.88Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.88Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.88Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.88Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.88Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.88Single7XW7K1-707XW7-TSH-K1-70
5.88Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.88Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.88Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.88Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.88Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.88Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.88Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.88Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.88Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.88Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.88Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.88Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.88Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.88Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.88Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.88Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.88Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.88Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.88Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.88Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.88Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.88Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.88Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.88Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.88Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.88Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.88Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.88Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.88Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.88Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.88Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.88Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.88Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.88Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.88Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.88Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.88Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.88Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.88Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.88Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.88Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.88Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.88Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
5.88Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
5.88Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.88Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8WVXNorrin8WVX-LGR4-Norrin
5.88Single8WVYNorrin8WVY-LGR4-Norrin
5.88Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.88Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.88Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.88Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.88Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.88Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.88Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.88Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.88Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.88Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.88Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.88Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.88Single9KHHNorrin9KHH-LGR4-Norrin
5.88Single9S37NB219S37-LGR4-NB21
5.88Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.56Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.26Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.26Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
5.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.00Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
5.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.76Single5L7DCholesterol5L7D-SMO-Cholesterol
4.76Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.76Single8HS2Fab0468HS2-GPR20-Fab046
4.76Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.76Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.76Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.55Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
4.55Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.55Consensusp2y_offOrthosteric Ligandp2y1_off
4.35Single4XNWMRS25004XNW-P2Y1-MRS2500
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
4.35Single8JPSCCL78JPS-ACKR1-CCL7
4.35Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.35Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.17Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.17Single6LI0C176LI0-GPR52-C17
4.17Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.17Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
4.17Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
4.17Single9B9Y7DY9B9Y-CB1-7DY
4.17Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
4.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.00Single4QINSAG1.54QIN-SMO-SAG1.5
4.00Single5U09Taranabant5U09-CB1-Taranabant
4.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
4.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
4.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
4.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
4.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
4.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
4.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
4.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
3.85Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
3.85Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.85Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
3.85Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.85Single7VV6C48/807VV6-MRGPRX2-C48/80
3.85Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.85Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.85Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9BA0A1AKN9BA0-CB1-A1AKN
3.85Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
3.85Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
3.85Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
3.85Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.85Consensusgrh_offOrthosteric Ligandgnrh1_off
3.85Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
3.85Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.70Single4QIMANTA XV4QIM-SMO-ANTA XV
3.70Single5T04Neurotensin5T04-NTS1-Neurotensin
3.70Single5TGZAM65385TGZ-CB1-AM6538
3.70Single6D27CAY104716D27-DP2-CAY10471
3.70Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
3.70Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
3.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
3.70Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.70Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
3.70Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
3.70Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
3.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.70Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
3.70Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
3.70Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
3.70Single7YXAONO-54306087YXA-S1P5-ONO-5430608
3.70Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.70Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.70Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
3.70Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
3.70Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
3.70Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
3.57Single4JKVTaladegib4JKV-SMO-Taladegib
3.57Single5C1MBU725C1M-μ-BU72
3.57Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.57Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.57Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
3.57Single7C4SS1P7C4S-S1P3-S1P
3.57Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
3.57Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
3.57Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.57Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
3.57Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
3.57Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
3.57Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
3.57Single9B9ZA1AKO9B9Z-CB1-A1AKO
3.57Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
3.57Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
3.57Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.57Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.57Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
3.57Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
3.45Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
3.45Single4BV0Neurotensin4BV0-NTS1-Neurotensin
3.45Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
3.45Single5V56TC1145V56-SMO-TC114
3.45Single5V57TC1145V57-SMO-TC114
3.45Single6OS1TRV0266OS1-AT1-TRV026
3.45Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.45Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
3.45Single7F1TMIP-1a7F1T-CCR5-MIP-1a
3.45Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
3.45Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
3.45Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
3.45Single7R0CAVP7R0C-V2-AVP-Arrestin2
3.45Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.45Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.45Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
3.45Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
3.45Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Single8E0GBU728E0G-μ-BU72
3.45Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
3.45Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
3.45Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.45Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
3.45Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
3.45Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
3.45Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.45Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.45Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
3.45Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
3.45Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Consensuslpa_onOrthosteric Ligandlpa1_on
3.45Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
3.45Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusneurotensin_onOrthosteric Ligandnts1_on
3.45Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.45Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.45Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.45Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.33Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
3.33Single4XESNeurotensin4XES-NTS1-Neurotensin
3.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
3.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
3.33Single6OS2TRV0266OS2-AT1-TRV026
3.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
3.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
3.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
3.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
3.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.33Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
3.33Single8XQJJN2418XQJ-Apelin-JN241
3.33Single8XWACXCL18XWA-CXCR2-CXCL1
3.33Single8XWMCXCL68XWM-CXCR2-CXCL6
3.33Single8XWSCXCL58XWS-CXCR2-CXCL5
3.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
3.33Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
3.33Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.33Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
3.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
3.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.33Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
3.33Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
3.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
3.33Consensuslpa_offOrthosteric Ligandlpa1_off
3.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
3.33Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
3.33Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
3.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.33Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.33Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.23Single4BUONeurotensin4BUO-NTS1-Neurotensin
3.23Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.23Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
3.23Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.23Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.23Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
3.23Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
3.23Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.23Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.23Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.23Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
3.23Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
3.23Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.23Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
3.23Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.23Single8XVUCXCL28XVU-CXCR2-CXCL2
3.23Single8XWFCXCL38XWF-CXCR2-CXCL3
3.23Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.23Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.23Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.23Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.23Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.23Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
3.23Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
3.23Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.23Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
3.12Single6KNMJN241-96KNM-Apelin-JN241-9
3.12Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.12Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.12Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
3.12Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
3.12Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
3.12Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
3.12Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.12Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
3.12Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.12Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single8QJ2pN1628QJ2-MC4-pN162-Gs
3.12Single8XQJJN2418XQJ-Apelin-JN241
3.12Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.12Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
3.12Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.12Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.12Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
3.12Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
3.03Single4XT1Fractalkine4XT1-US28-Fractalkine
3.03Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.03Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
3.03Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
3.03Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.03Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
3.03Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.03Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
3.03Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
3.03Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.03Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.03Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
3.03Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
3.03Single8XWNCXCL88XWN-CXCR2-CXCL8
3.03Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
3.03Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
3.03Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
3.03Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.03Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.03Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
3.03Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
3.03Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
3.03Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
3.03Consensuslpl_onOrthosteric Ligands1p_on lpa_on
3.03Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
3.03Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
3.03Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
2.94Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
2.94Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
2.94Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
2.94Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
2.94Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.94Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
2.94Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
2.94Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.94Single7SK5CXCL127SK5-ACKR3-CXCL12
2.94Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
2.94Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
2.94Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
2.94Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.94Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
2.94Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
2.94Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
2.94Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
2.94Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.94Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
2.94Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
2.86Single3OE0CVX153OE0-CXCR4-CVX15
2.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
2.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
2.86Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
2.86Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
2.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.86Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
2.86Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
2.86Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
2.86Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
2.86Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
2.86Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.86Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
2.86Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
2.86Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
2.86Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
2.86Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86Consensusangiotensin_onOrthosteric Ligandat1_on
2.86Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.86Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.86Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.86Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.86Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
2.86Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
2.86Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
2.86Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
2.86Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.86Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.86Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.78Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
2.78Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
2.78Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
2.78Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
2.78Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.78Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.78Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
2.78Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
2.78Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
2.78Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
2.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.78Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
2.78Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
2.78Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.78Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
2.78Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
2.78Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
2.78Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.78Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
2.78Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.78Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.78Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.78Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.78Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
2.78Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
2.78Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.78Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
2.78Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
2.78Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
2.78Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
2.78Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
2.78Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.78Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.78Consensusvasop-oxy_onOrthosteric Ligandv2_on
2.78Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
2.70Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
2.70Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
2.70Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
2.70Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
2.70Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
2.70Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
2.70Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.70Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.70Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
2.70Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
2.70Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.70Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.70Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.70Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
2.70Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
2.70Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
2.70Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
2.70Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
2.70Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
2.70Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.70Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.70Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
2.70Consensuscalcitonin_onOrthosteric Ligandctlike_on
2.70Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
2.70Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
2.70Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
2.70Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
2.70Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
2.70Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
2.70Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
2.70Consensuspac_onOrthosteric Ligandpac1_on
2.70Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.70Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
2.63Single4XT3Fractalkine4XT3-US28-Fractalkine
2.63Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
2.63Single6FJ3PTH6FJ3-PTH1-PTH
2.63Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.63Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.63Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.63Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
2.63Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.63Single7SK3CXCL127SK3-ACKR3-CXCL12
2.63Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
2.63Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.63Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
2.63Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.63Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
2.63Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
2.63Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
2.63Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
2.63Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.63Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
2.63Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
2.63Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
2.63Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
2.63Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.63Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
2.63Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.63Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.63Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
2.63Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
2.63Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
2.63Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
2.63Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.63Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.63Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
2.63Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
2.63Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.63Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
2.56Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.56Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
2.56Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.56Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
2.56Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
2.56Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
2.56Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
2.56Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
2.56Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.56Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.56Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
2.56Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
2.56Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.56Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.56Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.56Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
2.56Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.56Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
2.56Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
2.56Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
2.56Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.56Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.56Consensusglp_onOrthosteric Ligandglp1_on glp2_on
2.56Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
2.56Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
2.56Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.56Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.56Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.56Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
2.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.50Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
2.50Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.50Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
2.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.50Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.50Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
2.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
2.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
2.50Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.50Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
2.50Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
2.50Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.50Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.50Consensusbradykinin_onOrthosteric Ligandbk2_on
2.50Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
2.50Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.50Consensusendothelin_onOrthosteric Ligandetb_on eta_on
2.50Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.50Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
2.50Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.50Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
2.50Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
2.50Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.50Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.44Single5GLHEndothelin-15GLH-ETB-Endothelin-1
2.44Single6IGKEndothelin-36IGK-ETB-Endothelin-3
2.44Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.44Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.44Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.44Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
2.44Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
2.44Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
2.44Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.44Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.44Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.44Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
2.44Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
2.38Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
2.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.38Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.38Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.38Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
2.38Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.38Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
2.38Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
2.38Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
2.38Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
2.33Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
2.33Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
2.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.33Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.33Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
2.33Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
2.33Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.27Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.27Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.27Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
2.27Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
2.27Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
2.27Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.27Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.27Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.27Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
2.27Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
2.27Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.22Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.22Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.22Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.17Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.17Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.17Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.13Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.13Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.13Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.08Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.04Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.04Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
1.96Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
1.92Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 8Y69
Class A
SubFamily Orphan
Type Orphan
SubType LGR4
Species Homo Sapiens
Ligand R-spondin-2
Other Ligand(s) -
Protein Partners ZNRF3
PDB Resolution 3.38
Date 2024-12-04
D.O.I. doi.org/10.1038/s41467-024-55431-3
Net Summary
Imin 2.51
Number of Linked Nodes 1937
Number of Links 2402
Number of Hubs 401
Number of Links mediated by Hubs 1404
Number of Communities 90
Number of Nodes involved in Communities 574
Number of Links involved in Communities 772
Path Summary
Number Of Nodes in MetaPath 1095
Number Of Links MetaPath 1094
Number of Shortest Paths -2055947764
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 103
Minimum Path Strength 1.27
Average Path Strength 8.09151
Maximum Path Strength 23.68
Minimum Path Correlation 0.71
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 5.17241
Average % Of Corr. Nodes 124.627
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 105.036
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • tissue remodeling   • bone remodeling   • developmental process   • epithelium development   • cell population proliferation   • tube development   • morphogenesis of an epithelium   • tissue development   • renal system development   • epithelial cell proliferation involved in renal tubule morphogenesis   • tissue morphogenesis   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • anatomical structure development   • renal tubule development   • cellular process   • epithelial tube morphogenesis   • epithelial cell proliferation   • renal tubule morphogenesis   • system development   • cellular developmental process   • ossification   • cell differentiation   • osteoblast differentiation   • cellular response to stimulus   • positive regulation of response to biotic stimulus   • regulation of cellular process   • pattern recognition receptor signaling pathway   • response to stimulus   • toll-like receptor signaling pathway   • negative regulation of biological process   • regulation of signal transduction   • response to biotic stimulus   • cell communication   • immune response-activating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • signal transduction   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • regulation of biological process   • immune response   • response to other organism   • regulation of innate immune response   • response to external stimulus   • regulation of response to stimulus   • defense response to other organism   • regulation of pattern recognition receptor signaling pathway   • positive regulation of defense response   • activation of innate immune response   • regulation of immune response   • regulation of toll-like receptor signaling pathway   • activation of immune response   • regulation of defense response   • regulation of response to biotic stimulus   • biological process involved in interspecies interaction between organisms   • regulation of response to external stimulus   • signaling   • negative regulation of signaling   • positive regulation of biological process   • negative regulation of cell communication   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • immune response-regulating signaling pathway   • regulation of response to stress   • response to stress   • innate immune response   • negative regulation of cellular process   • response to external biotic stimulus   • regulation of signaling   • positive regulation of innate immune response   • defense response   • negative regulation of response to stimulus   • biological regulation   • defense response to symbiont   • negative regulation of signal transduction   • negative regulation of toll-like receptor signaling pathway   • negative regulation of immune system process   • immune system process   • regulation of cell communication   • spermatogenesis   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • developmental process involved in reproduction   • male gamete generation   • gamete generation   • bone mineralization   • animal organ development   • biomineral tissue development   • mesonephric epithelium development   • kidney epithelium development   • branching morphogenesis of an epithelial tube   • nephron tubule morphogenesis   • regulation of kidney development   • regulation of branching involved in ureteric bud morphogenesis   • positive regulation of developmental process   • animal organ morphogenesis   • nephron development   • regulation of morphogenesis of a branching structure   • regulation of animal organ morphogenesis   • positive regulation of multicellular organismal process   • mesonephric tubule development   • regulation of developmental process   • nephron morphogenesis   • nephron epithelium morphogenesis   • nephron tubule development   • ureteric bud morphogenesis   • positive regulation of morphogenesis of an epithelium   • branching involved in ureteric bud morphogenesis   • regulation of morphogenesis of an epithelium   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • nephron epithelium development   • ureteric bud development   • mesonephros development   • kidney morphogenesis   • morphogenesis of a branching structure   • positive regulation of branching involved in ureteric bud morphogenesis   • mesonephric tubule morphogenesis   • kidney development   • morphogenesis of a branching epithelium   • digestive system development   • digestive tract development   • epidermis development   • molting cycle process   • hair cycle   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • hair cycle process   • genitalia development   • reproductive system development   • sex differentiation   • male sex differentiation   • male genitalia development   • reproductive structure development   • multicellular organismal-level homeostasis   • homeostatic process   • homeostasis of number of cells   • intestinal stem cell homeostasis   • regulation of biosynthetic process   • rhythmic process   • circadian regulation of gene expression   • circadian rhythm   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • cytokine production   • regulation of cytokine production   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of multicellular organismal process   • metanephric tubule morphogenesis   • metanephric epithelium development   • metanephros development   • metanephros morphogenesis   • metanephric nephron tubule morphogenesis   • metanephric nephron development   • metanephric nephron epithelium development   • metanephric nephron tubule development   • metanephric nephron morphogenesis   • metanephric tubule development   • cell surface receptor signaling pathway   • Wnt signaling pathway   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • positive regulation of Wnt signaling pathway   • positive regulation of cellular process   • positive regulation of canonical Wnt signaling pathway   • regulation of Wnt signaling pathway   • positive regulation of signaling   • negative regulation of cold-induced thermogenesis   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • metanephric glomerulus development   • glomerulus development   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • aminoacyltransferase activity   • ubiquitin-like protein transferase activity   • catalytic activity, acting on a protein   • acyltransferase activity   • transferase activity   • catalytic activity   • ubiquitin-protein transferase activity   • cation binding   • transition metal ion binding   • zinc ion binding   • ion binding   • binding   • metal ion binding   • small molecule binding   • ubiquitin-like protein ligase activity   • ubiquitin protein ligase activity   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • frizzled binding   • catabolic process   • proteolysis involved in protein catabolic process   • primary metabolic process   • protein catabolic process   • macromolecule catabolic process   • modification-dependent macromolecule catabolic process   • modification-dependent protein catabolic process   • proteolysis   • ubiquitin-dependent protein catabolic process   • protein metabolic process   • limb development   • appendage development   • stem cell proliferation   • regulation of Wnt signaling pathway, planar cell polarity pathway   • Wnt signaling pathway, planar cell polarity pathway   • regulation of non-canonical Wnt signaling pathway   • non-canonical Wnt signaling pathway   • receptor catabolic process   • negative regulation of Wnt signaling pathway   • receptor metabolic process   • Wnt receptor catabolic process   • negative regulation of canonical Wnt signaling pathway   • protein ubiquitination   • macromolecule modification   • post-translational protein modification   • protein modification process   • protein modification by small protein conjugation   • protein modification by small protein conjugation or removal   • negative regulation of non-canonical Wnt signaling pathway   • BMP receptor binding   • receptor serine/threonine kinase binding   • transmembrane receptor protein serine/threonine kinase binding   • heparin binding   • glycosaminoglycan binding   • carbohydrate derivative binding   • sulfur compound binding   • regulation of odontogenesis of dentin-containing tooth   • negative regulation of developmental process   • regulation of odontogenesis   • odontogenesis of dentin-containing tooth   • odontogenesis   • negative regulation of odontogenesis   • negative regulation of odontogenesis of dentin-containing tooth   • negative regulation of animal organ morphogenesis   • lung growth   • developmental growth   • growth   • respiratory tube development   • organ growth   • lung development   • respiratory system development   • trachea cartilage morphogenesis   • connective tissue development   • trachea cartilage development   • trachea morphogenesis   • skeletal system development   • trachea development   • cartilage morphogenesis   • cartilage development   • embryonic forelimb morphogenesis   • embryonic limb morphogenesis   • embryonic morphogenesis   • embryonic appendage morphogenesis   • embryo development   • forelimb morphogenesis   • appendage morphogenesis   • limb morphogenesis   • lung morphogenesis   • epithelial tube branching involved in lung morphogenesis   • embryonic hindlimb morphogenesis   • hindlimb morphogenesis   • dopaminergic neuron differentiation   • nervous system development   • generation of neurons   • neurogenesis   • neuron differentiation   • cell surface   • extracellular region   • extracellular space
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainE
ProteinZNRF3
UniProtQ9ULT6
Sequence
>8Y69_Chain_E
KETAFVEVV LFETTYTTG LTGRFSRAG ATLSAEGEI VQMHPLGLC 
NNNDEEDLY EYGWVGVVK LEQPELDPK PCLTVLGKA KRAVQRGAT 
AVIFDVSEN PEAIDQLNQ GSEDPLKRP VVYVKGADA IKLMNIVNK 
QKVARARIQ HRPPRQPTE YFDMGIFLA FFVVVSLVC LILLVKIKL 
K


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9BXB1
Sequence
>8Y69_Chain_R
CSCDGDRRV DCSGKGLTA VPEGLSAFT QALDISMNN ITQLPEDAF 
NFPFLEELQ LAGNDLSFI HPKALSGLK ELKVLTLQN NQLKTVPSE 
AIRGLSALQ SLRLDANHI TSVPEDSFE GLVQLRHLW LDDNSLTEV 
PVHPLSNLP TLQALTLAL NKISSIPDF AFTNLSSLV VLHLHNNKI 
RSLSQHCFD GLDNLETLD LNYNNLGEF PQAIKALPS LKELGFHSN 
SISVIPDGA FDGNPLLRT IHLYDNPLS FVGNSAFHN LSDLHSLVI 
RGASMVQQF PNLTGTVHL ESLTLTGTK ISSIPNNLC QEQKMLRTL 
DLSYNNIRD LPSFNGCHA LEEISLQRN QIYQIKEGT FQGLISLRI 
LDLSRNLIH EIHSRAFAT LGPITNLDV SFNELTSFP TEGLNGLNQ 
LKLVGNFKL KEALAAKDF VNLRSLSVP YAYQCCAFW GCIIIHCTP 
STGAFKPCE YLLGSWMIR LTVWFIFLV ALFFNLLVI LTTFLPSSK 
LFIGLISVS NLFMGIYTG ILTFLDAVS WGRFAEFGI WWETGSGCK 
VAGFLAVFS SESAIFLLM LATVERSLS AKDNHLKQF RVAALLAFL 
GATVAGCFP LFHRGEYSA SPLCLPFPT GETPSLGFT VTLVLLNSL 
AFLLMAVIY TKLYCNLEE NSQSSMIKH VAWLIFTNC IFFCPVAFF 
SFAPLITAI SISPEIMKS VTLIFFPLP ACLNPVLYV FFNPKFKED 
WKLLKRRVT A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ9BXB1
Sequence
>8Y69_Chain_S
CSCDGDRRV DCSGKGLTA VPEGLSAFT QALDISMNN ITQLPEDAF 
NFPFLEELQ LAGNDLSFI HPKALSGLK ELKVLTLQN NQLKTVPSE 
AIRGLSALQ SLRLDANHI TSVPEDSFE GLVQLRHLW LDDNSLTEV 
PVHPLSNLP TLQALTLAL NKISSIPDF AFTNLSSLV VLHLHNNKI 
RSLSQHCFD GLDNLETLD LNYNNLGEF PQAIKALPS LKELGFHSN 
SISVIPDGA FDGNPLLRT IHLYDNPLS FVGNSAFHN LSDLHSLVI 
RGASMVQQF PNLTGTVHL ESLTLTGTK ISSIPNNLC QEQKMLRTL 
DLSYNNIRD LPSFNGCHA LEEISLQRN QIYQIKEGT FQGLISLRI 
LDLSRNLIH EIHSRAFAT LGPITNLDV SFNELTSFP TEGLNGLNQ 
LKLVGNFKL KEALAAKDF VNLRSLSVP YAYQCCAFW GCIIIHCTP 
STGAFKPCE YLLGSWMIR LTVWFIFLV ALFFNLLVI LTTFATSLP 
SSKLFIGLI SVSNLFMGI YTGILTFLD AVSWGRFAE FGIWWETGS 
GCKVAGFLA VFSSESAIF LLMLATVER SLSAKDNHL KQFRVAALL 
AFLGATVAG CFPLFHRGE YSASPLCLP FPTGETPSL GFTVTLVLL 
NSLAFLLMA VIYTKLYCN LEENSQSSM IKHVAWLIF TNCIFFCPV 
AFFSFAPLI TAISISPEI MKSVTLIFF PLPACLNPV LYVFFNPKF 
KEDWKLLKR RVTACA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainT
ProteinZNRF3
UniProtQ9ULT6
Sequence
>8Y69_Chain_T
KETAFVEVV LFETTYTTG LTGRFSRAG ATLSAEGEI VQMHPLGLC 
NNNDEEDLY EYGWVGVVK LEQPELDPK PCLTVLGKA KRAVQRGAT 
AVIFDVSEN PEAIDQLNQ GSEDPLKRP VVYVKGADA IKLMNIVNK 
QKVARARIQ HRPPRQEYF DMGIFLAFF VVVSLVCLI LLVKIKLK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XT9AOrphanOrphanLGR4Homo sapiens---3.12025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XUMAOrphanOrphanLGR4Homo sapiensR-spondin-2--2.92025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XFPAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.212024-12-04doi.org/10.1038/s41467-024-55431-3
8XFSAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.22024-12-04doi.org/10.1038/s41467-024-55431-3
8XFTAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.242024-12-04doi.org/10.1038/s41467-024-55431-3
8Y69AOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.382024-12-04doi.org/10.1038/s41467-024-55431-3
8WVUAOrphanOrphanLGR4Homo sapiensR-spondin-1-RNF433.612024-10-30To be published
8WVVAOrphanOrphanLGR4Homo sapiens---3.352024-10-30To be published
8WVWAOrphanOrphanLGR4Homo sapiens---3.532024-10-30To be published
8WVXAOrphanOrphanLGR4Homo sapiensNorrin--3.322024-10-30To be published
8WVYAOrphanOrphanLGR4Homo sapiensNorrin--3.292024-10-30To be published
9KGKAOrphanOrphanLGR4Homo sapiens---2.632025-07-16To be published
9KHHAOrphanOrphanLGR4Homo sapiensNorrin--3.652025-07-16To be published
9S37AOrphanOrphanLGR4Homo sapiensNB21--3.942025-07-30To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Y69.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.