Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I47 7.335405
2R:R:Y51 5.39333617
3R:R:F59 4.775466
4R:R:F69 7.5425407
5R:R:Y82 3.65808
6R:R:D90 6.97519
7R:R:W100 6.94637
8R:R:Y103 5.66435
9R:R:Y104 7.2225405
10R:R:Y108 6.3225405
11R:R:W110 9.12667639
12R:R:F112 8.244537
13R:R:F129 6.69497
14R:R:W133 4.55333696
15R:R:Y143 5.36408
16R:R:V164 4.5975407
17R:R:W168 5.6025479
18R:R:F181 9.8025424
19R:R:I187 4.325442
20R:R:Y189 5.0975441
21R:R:L190 3.445441
22R:R:C195 7.79439
23R:R:F199 9.79333624
24R:R:Y204 8.48421
25R:R:W207 7.24426
26R:R:S208 7.9175424
27R:R:F220 7.735418
28R:R:P223 3.75409
29R:R:L224 4.2925416
30R:R:Y231 3.725409
31R:R:I234 2.324508
32R:R:F265 5.11519
33R:R:W269 8.315619
34R:R:F272 7.282516
35R:R:W283 6.26714723
36R:R:V292 2.6825402
37R:R:I304 5.26415
38R:R:F308 5.395617
39R:R:N310 6.61419
40R:R:N314 9.048519
41R:R:Y318 7.694519
42L:L:?1 4.37420
43L:L:R2 6.192520
44L:L:Y4 5.404500
45L:L:H6 9.8875400
46L:L:I8 5.5625410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 L:L:R2 10.51723.78YesYes200
2L:L:H6 R:R:P301 11.9286.1YesNo004
3R:R:I47 R:R:Y104 13.16027.25YesYes055
4L:L:R2 R:R:D279 10.9344.76YesNo205
5L:L:Y4 R:R:D279 24.72175.75YesNo005
6L:L:I8 L:L:Y4 88.2694.84YesYes000
7R:R:I304 R:R:Y51 23.21473.63YesYes157
8L:L:I8 R:R:F308 30.91933.77YesYes107
9R:R:F308 R:R:Y51 11.75856.19YesYes177
10R:R:F308 R:R:L97 13.51296.09YesNo178
11R:R:L97 R:R:P98 15.14821.64NoNo089
12R:R:F55 R:R:P98 11.355413NoNo079
13R:R:F308 R:R:V93 30.53915.24YesNo077
14R:R:S311 R:R:V93 29.30246.46NoNo097
15R:R:D90 R:R:S311 26.22428.83YesNo099
16R:R:D90 R:R:N62 14.14968.08YesNo099
17R:R:N62 R:R:P315 12.77549.77NoNo099
18L:L:I8 R:R:F272 80.94456.28YesYes106
19R:R:F272 R:R:W269 1007.02YesYes169
20R:R:N310 R:R:W269 95.75376.78YesYes199
21R:R:I135 R:R:N310 42.49464.25NoYes189
22R:R:I135 R:R:Y318 41.43194.84NoYes189
23R:R:M138 R:R:Y318 81.008711.97NoYes099
24R:R:M138 R:R:Y82 76.84943.59NoYes098
25R:R:I81 R:R:Y82 19.00053.63NoYes078
26R:R:F69 R:R:I81 16.62323.77YesNo077
27R:R:N310 R:R:N314 50.359612.26YesYes199
28R:R:N314 R:R:Y318 57.90858.14YesYes199
29R:R:V78 R:R:Y82 16.57732.52NoYes068
30R:R:P157 R:R:V78 12.23033.53NoNo026
31R:R:V164 R:R:Y82 21.37332.52YesYes078
32R:R:N85 R:R:V164 14.63068.87NoYes097
33R:R:F112 R:R:W110 18.134814.03YesYes379
34R:R:F308 R:R:L124 31.92257.31YesNo076
35R:R:L190 R:R:V192 10.32482.98YesNo013
36L:L:V3 R:R:Y204 30.40637.57NoYes001
37L:L:V3 R:R:I196 11.314210.75NoNo004
38R:R:F199 R:R:M197 13.03197.46YesNo244
39R:R:M197 R:R:R182 14.90548.69NoNo045
40R:R:R182 R:R:T178 12.16622.59NoNo055
41R:R:T125 R:R:T178 12.184510.99NoNo045
42R:R:S208 R:R:W283 15.468814.83YesYes243
43R:R:F199 R:R:S208 19.00517.93YesYes244
44R:R:M128 R:R:W269 29.51318.14NoYes079
45R:R:F129 R:R:M128 28.34966.22YesNo077
46R:R:F129 R:R:W133 23.787310.02YesYes976
47R:R:F265 R:R:W269 54.39054.01YesYes199
48R:R:P223 R:R:W133 15.53754.05YesYes096
49R:R:F265 R:R:I227 47.46467.54YesNo098
50R:R:I227 R:R:S139 44.52386.19NoNo089
51R:R:C230 R:R:S139 43.03973.44NoNo079
52R:R:V261 R:R:Y318 11.53418.83NoYes089
53R:R:C230 R:R:Y143 40.0444.03NoYes078
54R:R:I147 R:R:Y143 11.781412.09NoYes078
55R:R:I234 R:R:Y143 24.65762.42YesYes088
56R:R:F199 R:R:W207 10.164410.02YesYes246
57L:L:V3 R:R:I187 18.51046.14NoYes002
58R:R:P200 R:R:W207 10.04995.4NoYes056
59R:R:F272 R:R:H273 24.90959.05YesNo068
60R:R:H273 R:R:N216 17.44777.65NoNo086
61R:R:F272 R:R:T276 20.60837.78YesNo066
62R:R:N216 R:R:T276 15.66125.85NoNo066
63R:R:F277 R:R:N216 29.59558.46NoNo066
64R:R:F220 R:R:H273 10.155315.84YesNo088
65R:R:I234 R:R:V254 11.77681.54YesNo088
66R:R:L238 R:R:V254 10.23774.47NoNo088
67R:R:F277 R:R:L281 26.34334.87NoNo065
68R:R:I287 R:R:L281 19.81134.28NoNo015
69R:R:I287 R:R:V292 16.53154.61NoYes012
70R:R:A209 R:R:W283 13.79232.59NoYes033
71L:L:?1 R:R:W283 12.40443.54YesYes203
72L:L:Y4 R:R:S208 54.12953.82YesYes004
73R:R:D279 R:R:W283 13.15567.82NoYes253
74R:R:C195 R:R:R182 11.76314.18YesNo095
75R:R:F129 R:R:T125 16.03682.59YesNo074
76R:R:S208 R:R:Y204 24.2275.09YesYes241
77R:R:I47 R:R:Y51 17.37443.63YesYes057
78R:R:L124 R:R:W100 30.52549.11NoYes067
79R:R:F272 R:R:I304 33.44786.28YesYes165
80R:R:D90 R:R:N314 24.27286.73YesYes199
81L:L:H6 L:L:Y4 15.80325.44YesYes000
82R:R:I187 R:R:L190 14.01224.28YesYes421
83R:R:W100 R:R:W110 20.95647.5YesYes379
84R:R:F308 R:R:I304 13.78323.77YesYes175
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S36 R:R:Y189 7.63 0 No Yes 5 1 1 2
L:L:?1 R:R:S36 4.67 2 Yes No 0 5 0 1
R:R:P39 R:R:Y108 5.56 0 No Yes 1 5 2 1
R:R:L44 R:R:P301 4.93 0 No No 5 4 2 1
R:R:I47 R:R:Y51 3.63 0 Yes Yes 5 7 2 2
R:R:I47 R:R:Y104 7.25 0 Yes Yes 5 5 2 1
R:R:L97 R:R:Y51 10.55 1 No Yes 8 7 2 2
R:R:I304 R:R:Y51 3.63 1 Yes Yes 5 7 1 2
R:R:F308 R:R:Y51 6.19 1 Yes Yes 7 7 1 2
R:R:F308 R:R:V93 5.24 1 Yes No 7 7 1 2
R:R:T96 R:R:W100 4.85 0 No Yes 7 7 2 1
R:R:F308 R:R:L97 6.09 1 Yes No 7 8 1 2
R:R:W100 R:R:Y103 3.86 3 Yes Yes 7 5 1 2
R:R:W100 R:R:W110 7.5 3 Yes Yes 7 9 1 2
R:R:L124 R:R:W100 9.11 0 No Yes 6 7 2 1
L:L:P7 R:R:W100 13.51 0 No Yes 0 7 0 1
R:R:Y103 R:R:Y108 9.93 3 Yes Yes 5 5 2 1
R:R:W110 R:R:Y103 4.82 3 Yes Yes 9 5 2 2
R:R:Y104 R:R:Y108 4.96 0 Yes Yes 5 5 1 1
R:R:P301 R:R:Y104 8.34 0 No Yes 4 5 1 1
L:L:P7 R:R:Y104 8.34 0 No Yes 0 5 0 1
L:L:I5 R:R:Y108 4.84 0 No Yes 0 5 0 1
R:R:F308 R:R:L124 7.31 1 Yes No 7 6 1 2
R:R:I196 R:R:R185 3.76 0 No No 4 1 1 2
R:R:I187 R:R:Y189 3.63 4 Yes Yes 2 1 1 2
R:R:I187 R:R:L190 4.28 4 Yes Yes 2 1 1 2
L:L:V3 R:R:I187 6.14 0 No Yes 0 2 0 1
R:R:E188 R:R:Y189 5.61 0 No Yes 1 1 1 2
L:L:?1 R:R:E188 5.49 2 Yes No 0 1 0 1
R:R:L190 R:R:Y189 3.52 4 Yes Yes 1 1 2 2
L:L:V3 R:R:I196 10.75 0 No No 0 4 0 1
R:R:F199 R:R:Y204 15.47 2 Yes Yes 4 1 2 1
R:R:F199 R:R:S208 7.93 2 Yes Yes 4 4 2 1
R:R:S208 R:R:Y204 5.09 2 Yes Yes 4 1 1 1
R:R:W283 R:R:Y204 5.79 2 Yes Yes 3 1 1 1
L:L:V3 R:R:Y204 7.57 0 No Yes 0 1 0 1
R:R:S208 R:R:W283 14.83 2 Yes Yes 4 3 1 1
L:L:Y4 R:R:S208 3.82 0 Yes Yes 0 4 0 1
L:L:Y4 R:R:K215 7.17 0 Yes No 0 4 0 1
R:R:F272 R:R:W269 7.02 1 Yes Yes 6 9 1 2
R:R:F272 R:R:H273 9.05 1 Yes No 6 8 1 2
R:R:F272 R:R:T276 7.78 1 Yes No 6 6 1 2
R:R:F272 R:R:I304 6.28 1 Yes Yes 6 5 1 1
L:L:I8 R:R:F272 6.28 1 Yes Yes 0 6 0 1
R:R:L275 R:R:L300 6.92 0 No No 5 4 2 1
R:R:D279 R:R:W283 7.82 2 No Yes 5 3 1 1
L:L:R2 R:R:D279 4.76 2 Yes No 0 5 0 1
L:L:Y4 R:R:D279 5.75 0 Yes No 0 5 0 1
L:L:?1 R:R:W283 3.54 2 Yes Yes 0 3 0 1
L:L:R2 R:R:W283 8 2 Yes Yes 0 3 0 1
L:L:R2 R:R:D297 11.91 2 Yes No 0 4 0 1
L:L:I5 R:R:D297 4.2 0 No No 0 4 0 1
L:L:H6 R:R:D297 13.87 0 Yes No 0 4 0 1
L:L:H6 R:R:L300 14.14 0 Yes No 0 4 0 1
L:L:H6 R:R:P301 6.1 0 Yes No 0 4 0 1
R:R:F308 R:R:I304 3.77 1 Yes Yes 7 5 1 1
L:L:I8 R:R:I304 7.36 1 Yes Yes 0 5 0 1
L:L:I8 R:R:F308 3.77 1 Yes Yes 0 7 0 1
R:R:A194 R:R:I187 3.25 0 No Yes 4 2 2 1
R:R:A282 R:R:I293 3.25 0 No No 3 3 2 1
R:R:G121 R:R:W100 2.81 0 No Yes 5 7 2 1
R:R:A209 R:R:W283 2.59 0 No Yes 3 3 2 1
L:L:R2 R:R:I293 2.51 2 Yes No 0 3 0 1
R:R:C35 R:R:I293 1.64 0 No No 9 3 2 1
R:R:A205 R:R:W283 1.3 0 No Yes 2 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
71.43Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
65.22Single6JODAngiotensin II6JOD-AT2-Angiotensin II
64.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
62.50Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
61.54Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
59.09Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
57.14Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
56.52Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
56.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
55.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
55.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
54.55Single6KNMJN241-96KNM-Apelin-JN241-9
54.55Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
52.63Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
52.17Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
52.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
50.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
50.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
50.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
50.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
50.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
50.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
50.00Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
48.28Single5GLHEndothelin-15GLH-ETB-Endothelin-1
48.28Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
48.00Consensusangiotensin_onOrthosteric Ligandat1_on
48.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
47.83Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
47.62Single6OS1TRV0266OS1-AT1-TRV026
47.62Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
47.62Consensuschemerin_onOrthosteric Ligandcml1_on
47.62Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
46.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
46.43Consensusendothelin_onOrthosteric Ligandetb_on eta_on
46.15Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
46.15Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
46.15Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
46.15Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
45.83Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
45.83Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
45.83Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
45.83Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
45.45Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
45.45Single6OS2TRV0266OS2-AT1-TRV026
45.16Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
44.83Single6IGLIRL16206IGL-ETB-IRL1620
44.83Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
44.44Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
44.44Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
44.44Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
44.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
44.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
43.48Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
43.48Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
43.48Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
43.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
42.86Single7SK3CXCL127SK3-ACKR3-CXCL12
42.86Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
42.31Single3OE0CVX153OE0-CXCR4-CVX15
42.31Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
42.31Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
42.31Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
42.31Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
42.31Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.11Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
42.11Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
41.67Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
41.67Consensuslpl_offOrthosteric Ligands1p_off lpa_off
41.67Consensuslpl_onOrthosteric Ligands1p_on lpa_on
41.67Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
41.38Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.38Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
40.91Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.74Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
40.74Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
40.74Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
40.74Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
40.74Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
40.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
40.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
40.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
40.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
40.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
40.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
39.29Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
39.29Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
39.29Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
39.13Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
39.13Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
39.13Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
39.13Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
39.13Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.13Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
39.13Consensuschemokine_offOrthosteric Ligandcxcr_off
39.13Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
39.13Consensuscxcr_offOrthosteric Ligandcxcr4_off
39.13Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
39.13Consensusdp_offOrthosteric Liganddp2_off
39.13Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
39.13Consensusgs_steroidOrthosteric Ligandgs_bileacid
38.46Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
38.46Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
38.46Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
38.46Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
38.10Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
37.93Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
37.93Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
37.93Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
37.50Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
37.50Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
37.50Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
37.50Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
37.50Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
37.50Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
37.50Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
37.50Consensussteroid_onOrthosteric Ligandbileacid_on
37.04Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.04Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
37.04Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
37.04Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
37.04Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
36.84Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
36.67Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
36.67Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
36.36Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
36.36Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.36Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
36.36Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
36.00Single5WF6UK-4320975WF6-A2A-UK-432097
36.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
36.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
36.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
36.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
36.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
35.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
35.29Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
35.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
35.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
35.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
34.78Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
34.78Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
34.78Single7F1TMIP-1a7F1T-CCR5-MIP-1a
34.78Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
34.78Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
34.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
34.78Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
34.78Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
34.78Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
34.78Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
34.78Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
34.78Consensuslpa_offOrthosteric Ligandlpa1_off
34.78Consensuslpa_onOrthosteric Ligandlpa1_on
34.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
34.62Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
34.62Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.62Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.62Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
34.62Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
34.62Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
34.62Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
34.62Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.48Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.48Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
34.48Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
33.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
33.33Single4XESNeurotensin4XES-NTS1-Neurotensin
33.33Single4XT3Fractalkine4XT3-US28-Fractalkine
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
33.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7SK5CXCL127SK5-ACKR3-CXCL12
33.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
33.33Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
33.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
33.33Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
33.33Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
32.26Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
32.26Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
32.14Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
32.14Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
32.14Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
32.14Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
32.14Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.14Single7XNACYN1548067XNA-SST2-CYN154806
32.14Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
32.14Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
32.14Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
32.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
32.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
32.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
32.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
32.00Single7EZCUKA7EZC-A2A-UKA
32.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
32.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
32.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
32.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
32.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
31.82Single6D27CAY104716D27-DP2-CAY10471
31.82Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
31.82Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
31.82Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
31.82Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
31.82Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
31.82Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
31.82Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
31.82Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
31.82Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
31.82Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.82Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
31.82Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
31.82Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.82Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
31.58Single4XNWMRS25004XNW-P2Y1-MRS2500
31.58Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.58Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
31.43Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.43Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.43Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
31.25Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
31.03Single7C61Ergotamine7C61-5-HT1B-Ergotamine
31.03Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
31.03Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.03Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
30.77Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.77Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
30.77Single7SK9CCX6627SK9-ACKR3-CCX662
30.77Single7XN9L-054,5227XN9-SST2-L-054,522
30.77Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
30.77Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
30.77Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
30.77Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
30.77Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
30.77Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
30.77Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
30.77Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.77Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.43Single5C1MBU725C1M-μ-BU72
30.43Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.43Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.43Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.43Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
30.43Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
30.43Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
30.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
30.00Single5L7IVismodegib5L7I-SMO-Vismodegib
30.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
30.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
30.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
30.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
30.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
30.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
29.63Single7F8XNN90567F8X-CCKA-NN9056
29.63Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
29.63Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
29.63Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
29.63Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
29.63Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
29.63Consensussst_onOrthosteric Ligandsst2_on sst4_on
29.41Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
29.17Single4BV0Neurotensin4BV0-NTS1-Neurotensin
29.17Single4RWADIPP-NH24RWA-δ-DIPP-NH2
29.17Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
29.17Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
29.17Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
29.17Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
29.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
29.17Single8E0GBU728E0G-μ-BU72
29.17Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.17Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
29.17Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
29.17Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensuscck_onOrthosteric Ligandccka_on cckb_on
29.17Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.17Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
29.17Consensusrelaxin_onOrthosteric Ligandrxfp4_on
29.03Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.03Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.03Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single3PWHZM2413853PWH-A2A-ZM241385
28.57Single3QAKUK-4320973QAK-A2A-UK-432097
28.57Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
28.57Single4QINSAG1.54QIN-SMO-SAG1.5
28.57Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
28.57Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.57Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.57Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
28.57Consensussst_offOrthosteric Ligandsst2_off
28.12Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
28.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.00Single6A93Risperidone6A93-5-HT2A-Risperidone
28.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
28.00Single6MXTSalmeterol6MXT-β2-Salmeterol
28.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.00Single7K15MKD0467K15-BLT1-MKD046-Na
28.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
28.00Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
28.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
28.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
28.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
28.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.00Consensusblt_offOrthosteric Ligandblt1_off
28.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
28.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
28.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
28.00Consensusnts_onOrthosteric Ligandnts1_on
28.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
27.78Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
27.59Single5WF5UK-4320975WF5-A2A-UK-432097
27.59Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
27.27Single3REYPubChem 56973REY-A2A-PubChem 5697
27.27Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.27Single6MH8ZM2413856MH8-A2A-ZM241385
27.27Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.27Single7AROLUF58337ARO-A2A-LUF5833-Na
27.27Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
27.27Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
27.27Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.27Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
27.27Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.27Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
27.27Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
27.27Single8K5CAcipimox8K5C-HCA2-Acipimox
27.27Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
27.27Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
27.27Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.27Consensushcar_onOrthosteric Ligandhca_on
26.92Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.92Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.92Single6IBLArformoterol6IBL-β1-Arformoterol
26.92Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.92Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.92Consensusorexin_onOrthosteric Ligandox2_on
26.92Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
26.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.67Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.67Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
26.09Single5T04Neurotensin5T04-NTS1-Neurotensin
26.09Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.09Single6LPJZM2413856LPJ-A2A-ZM241385-Na
26.09Single6LPKZM2413856LPK-A2A-ZM241385-Na
26.09Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
26.09Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
26.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
26.09Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
26.09Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.09Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
26.09Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.09Single8K5DGSK2560738K5D-HCA2-GSK256073
26.09Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.09Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.09Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.09Consensusblt_onOrthosteric Ligandblt1_on
26.09Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusgi_hcarOrthosteric Ligandgi_hca
26.09Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.09Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.09Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
26.09Consensusleuko_onOrthosteric Ligandblt_on
26.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
25.93Single4UG2CGS216804UG2-A2A-CGS21680
25.93Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.93Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.93Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
25.93Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
25.93Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
25.93Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.93Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
25.93Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.93Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
25.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
25.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
25.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
25.00Single6S0QZM2413856S0Q-A2A-ZM241385
25.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
25.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
25.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
25.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
25.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
25.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
25.00Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
25.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
25.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
25.00Consensusep_offOrthosteric Ligandep4_off
25.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
25.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
24.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.24Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
24.14Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
24.14Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
24.14Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
24.14Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
24.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
24.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
24.00Single5V56TC1145V56-SMO-TC114
24.00Single5V57TC1145V57-SMO-TC114
24.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
24.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
24.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
24.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
24.00Single7PX4PSB-21137PX4-A2A-PSB-2113
24.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
24.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
24.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
24.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
24.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
24.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
24.00Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
24.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
24.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
24.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
23.81Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.81Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.81Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.81Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.81Single8K5BNiacin8K5B-HCA2-Niacin
23.81Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
23.81Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
23.81Consensusgo_proteinOrthosteric Ligandgo_chemokine
23.81Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
23.81Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
23.53Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.53Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
23.33Single6PT2KGCHM076PT2-δ-KGCHM07
23.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
23.33Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
23.08Single4N4WSANT-14N4W-SMO-SANT-1
23.08Single4PY02MeSATP4PY0-P2Y12-2MeSATP
23.08Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
23.08Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
23.08Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
23.08Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.08Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
23.08Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
23.08Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
23.08Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
23.08Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.08Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.08Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
23.08Single7YITNalfurafine7YIT-κ-Nalfurafine
23.08Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
23.08Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
23.08Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
23.08Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.08Single8JJ8Formoterol8JJ8-β2-Formoterol
23.08Single8JJLOlodaterol8JJL-β2-Olodaterol
23.08Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Single8WU1KCA8WU1-CB1-KCA-Arrestin1
23.08Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
23.08Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
23.08Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
23.08Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.08Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.08Consensusgi_class-fOther Ligandgi_frizzled
23.08Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
23.08Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.08Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
23.08Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
23.08Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
22.86Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.86Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
22.86Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
22.86Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
22.73Single5WS3EMPA5WS3-OX2-EMPA
22.73Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.73Single6AKYMaraviroc6AKY-CCR5-Maraviroc
22.73Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
22.73Single7BR3Elagolix7BR3-GnRH1-Elagolix
22.73Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
22.73Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
22.73Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.73Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
22.73Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
22.73Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.73Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.73Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
22.73Consensusclass-f_offOrthosteric Ligandsmo_off
22.73Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
22.58Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
22.58Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
22.58Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
22.22Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
22.22Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
22.22Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
22.22Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
22.22Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
22.22Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
22.22Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
22.22Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.22Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
22.22Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
22.22Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
22.22Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
22.22Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
22.22Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.22Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
22.22Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
22.22Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.22Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
21.88Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
21.88Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.88Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
21.74Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
21.74Single4MBSMaraviroc4MBS-CCR5-Maraviroc
21.74Single4ZJCSB-6740424ZJC-OX1-SB-674042
21.74Single5IU4ZM2413855IU4-A2A-ZM241385-Na
21.74Single5IUBQ274563445IUB-A2A-Q27456344-Na
21.74Single5K2BZM2413855K2B-A2A-ZM241385-Na
21.74Single5K2CZM2413855K2C-A2A-ZM241385-Na
21.74Single5NLXZM2413855NLX-A2A-ZM241385-Na
21.74Single5NM4ZM2413855NM4-A2A-ZM241385-Na
21.74Single6AQFZM2413856AQF-A2A-ZM241385
21.74Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.74Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.74Single6TPGEMPA6TPG-OX2-EMPA
21.74Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.74Single7T32ZM2413857T32-A2A-ZM241385
21.74Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
21.74Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
21.74Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.74Single8GGTEpinephrine8GGT-β2-Epinephrine
21.74Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
21.74Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
21.74Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
21.74Single8K2WAMG4878K2W-CXCR3-AMG487
21.74Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.74Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
21.74Consensusgi_class-fOrthosteric Ligandgi_frizzled
21.74Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.74Consensusgnrh_offOrthosteric Ligandgnrh1_off
21.74Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
21.74Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
21.74Consensuss1p_offOrthosteric Ligands1p1_off
21.62Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
21.43Single3NY9PubChem 9131033NY9-β2-PubChem 913103
21.43Single5ZTYAM102575ZTY-CB2-AM10257
21.43Single6PT3DPI-2876PT3-δ-DPI-287
21.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
21.43Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8X5YAstemizole8X5Y-H1-Astemizole
21.43Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.43Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
21.43Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.21Single6FJ3PTH6FJ3-PTH1-PTH
21.21Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
21.21Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.05Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
21.05Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
21.05Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.83Single2Y01Dobutamine2Y01-β1-Dobutamine
20.83Single3EMLZM2413853EML-A2A-ZM241385
20.83Single4EIYZM2413854EIY-A2A-ZM241385-Na
20.83Single4EJ4Naltrindole4EJ4-δ-Naltrindole
20.83Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.83Single5IU8Q274563475IU8-A2A-Q27456347-Na
20.83Single5K2AZM2413855K2A-A2A-ZM241385-Na
20.83Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.83Single5OLGZM2413855OLG-A2A-ZM241385-Na
20.83Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.83Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.83Single5TGZAM65385TGZ-CB1-AM6538
20.83Single5UENDU1725UEN-A1-DU172
20.83Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
20.83Single5VRAZM2413855VRA-A2A-ZM241385-Na
20.83Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.83Single6IIVDaltroban6IIV-TP-Daltroban
20.83Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
20.83Single6S0LZM2413856S0L-A2A-ZM241385
20.83Single6TOTLemborexant6TOT-OX1-Lemborexant
20.83Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.83Single7BU7BI1671077BU7-β1-BI167107
20.83Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
20.83Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
20.83Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.83Single7PYRPSB-21157PYR-A2A-PSB-2115
20.83Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
20.83Single7UL4Alvimopan7UL4-μ-Alvimopan
20.83Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
20.83Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
20.83Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
20.83Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.83Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
20.83Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
20.83Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
20.83Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.83Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
20.83Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
20.83Consensusa2_offOrthosteric Liganda2a_off
20.83Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
20.83Consensusadenosine_onOrthosteric Liganda1_on a2_on
20.83Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.83Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
20.83Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
20.83Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.83Consensusnucleotide_onOrthosteric Ligandadenosine_on
20.83Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
20.83Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
20.83Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
20.83Consensustar_onOrthosteric Ligandta1_on
20.83Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
20.69Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.69Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.69Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
20.69Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.69Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.59Consensusgo_class-b1Orthosteric Ligandgo_crf
20.59Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single2Y00Dobutamine2Y00-β1-Dobutamine
20.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
20.00Single5N2SPSB365N2S-A1-PSB36
20.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
20.00Single5WQCEMPA5WQC-OX2-EMPA
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
20.00Single6HLOAprepitant6HLO-NK1-Aprepitant
20.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
20.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
20.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
20.00Single6TP6Filorexant6TP6-OX1-Filorexant
20.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
20.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
20.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
20.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7XKAEpinephrine7XKA-β2-Epinephrine
20.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
20.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
20.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
20.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
20.00Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
20.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
20.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
20.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
20.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
20.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
20.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
20.00Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
20.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
19.51Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.44Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
19.44Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.35Single6W25SHU91196W25-MC4-SHU9119-Ca
19.35Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
19.23Single2YDVNECA2YDV-A2A-NECA
19.23Single3P0GBI1671073P0G-β2-BI167107
19.23Single4UHRCGS216804UHR-A2A-CGS21680
19.23Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
19.23Single5G53NECA5G53-A2A-NECA-Gs
19.23Single5X93K-87945X93-ETB-K-8794
19.23Single5XR8AM8415XR8-CB1-AM841
19.23Single5XRAAM115425XRA-CB1-AM11542
19.23Single6J21Aprepitant6J21-NK1-Aprepitant
19.23Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
19.23Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.23Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
19.23Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
19.23Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
19.23Single7TUYGSK682753A7TUY-GPR183-GSK682753A
19.23Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
19.23Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
19.23Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
19.23Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
19.23Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
19.23Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
19.23Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
19.23Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
19.23Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
19.23Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
19.23Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
19.23Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
19.23Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
19.23Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
19.23Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
19.23Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.23Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
19.23Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
19.23Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
19.23Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
19.05Single3OE6IT1t3OE6-CXCR4-IT1t
19.05Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
19.05Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
19.05Single6LI0GTPL98046LI0-GPR52-GTPL9804
19.05Single6ME5Agomelatine6ME5-MT1-Agomelatine
19.05Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
19.05Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
19.05Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
19.05Single8GGZEpinephrine8GGZ-β2-Epinephrine
19.05Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
19.05Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
19.05Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
18.92Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.92Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
18.92Consensusglp_onOrthosteric Ligandglp1_on glp2_on
18.75Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
18.75Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
18.75Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
18.52Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
18.52Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
18.52Single4AMIBucindolol4AMI-β1-Bucindolol
18.52Single4LDEBI1671074LDE-β2-BI167107
18.52Single5X33BIIL2605X33-BLT1-BIIL260
18.52Single6CM4Risperidone6CM4-D2-Risperidone
18.52Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
18.52Single6IIURamatroban6IIU-TP-Ramatroban
18.52Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
18.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
18.52Single7DFPSpiperone7DFP-D2-Spiperone
18.52Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
18.52Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
18.52Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.52Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
18.52Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
18.52Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
18.52Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.52Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
18.52Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
18.52Single8JWZAB9288JWZ-A2A-AB928-Na
18.52Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
18.52Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
18.52Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
18.52Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
18.52Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.52Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
18.52Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
18.52Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
18.52Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
18.52Consensusnts_offOrthosteric Ligandnts1_off
18.52Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
18.52Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.42Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single3OE9IT1t3OE9-CXCR4-IT1t
18.18Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.18Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
18.18Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
18.18Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
18.18Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.18Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.18Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
18.18Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.18Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
18.18Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
18.18Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Single8GGYEpinephrine8GGY-β2-Epinephrine
18.18Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
18.18Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
18.18Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.18Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.18Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
18.18Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.95Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
17.95Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.86Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
17.86Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
17.86Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
17.86Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
17.86Single6H7LDobutamine6H7L-β1-Dobutamine
17.86Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
17.86Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
17.86Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
17.86Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
17.86Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
17.86Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
17.86Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
17.86Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
17.86Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
17.86Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
17.86Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
17.86Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
17.86Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
17.86Consensusendothelin_offOrthosteric Ligandetb_off
17.86Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
17.86Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
17.86Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.65Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
17.65Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.65Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.39Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
17.39Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
17.39Single3ODUIT1t3ODU-CXCR4-IT1t
17.39Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
17.39Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
17.39Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.39Single5K2DZM2413855K2D-A2A-ZM241385
17.39Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.39Single6AKXA4R6AKX-CCR5-A4R
17.39Single6JZHZM2413856JZH-A2A-ZM241385-Na
17.39Single6KUXRS-799486KUX-α2a-RS-79948
17.39Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.39Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.39Single6PS7ZM2413856PS7-A2A-ZM241385-Na
17.39Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
17.39Single6TODEMPA6TOD-OX1-EMPA-Na
17.39Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.39Single7F8ULintitript7F8U-CCKA-Lintitript
17.39Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
17.39Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
17.39Single7XRRLemborexant7XRR-OX2-Lemborexant
17.39Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
17.39Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
17.39Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
17.39Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
17.39Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8GGVEpinephrine8GGV-β2-Epinephrine
17.39Single8GGWEpinephrine8GGW-β2-Epinephrine
17.39Single8GGXEpinephrine8GGX-β2-Epinephrine
17.39Single8GH0Epinephrine8GH0-β2-Epinephrine
17.39Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
17.39Single8IHKAcifran8IHK-HCA3-Acifran
17.39Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.39Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.39Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
17.39Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
17.39Consensusalpha1_onOrthosteric Ligandalpha1a_on
17.39Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
17.39Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
17.39Consensusgt_class-aOrthosteric Ligandgt_opsin
17.39Consensusgt_opsinOrthosteric Ligandgt_sensory
17.39Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.39Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.24Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.24Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
17.24Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
17.24Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
17.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.14Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
17.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
17.14Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.14Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.07Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.67Single2YDOAdenosine2YDO-A2A-Adenosine
16.67Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
16.67Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
16.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
16.67Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
16.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5JTBZM2413855JTB-A2A-ZM241385
16.67Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
16.67Single5UVIZM2413855UVI-A2A-ZM241385
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.67Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6PS4ICI 118-5516PS4-β2-ICI 118-551
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6V9SGTPL114036V9S-OX1-GTPL11403
16.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
16.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
16.67Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
16.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
16.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
16.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
16.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
16.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGIEpinephrine8GGI-β2-Epinephrine
16.67Single8GGQEpinephrine8GGQ-β2-Epinephrine
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
16.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
16.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
16.67Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
16.67Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
16.67Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
16.67Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
16.28Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
16.22Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.13Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.13Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.13Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
16.00Single2Y02Carmoterol2Y02-β1-Carmoterol
16.00Single2Y04Salbutamol2Y04-β1-Salbutamol
16.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
16.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
16.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
16.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
16.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
16.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
16.00Single4YAYZD-71554YAY-AT1-ZD-7155
16.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
16.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
16.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.00Single6GPSMK08126GPS-CCR2-MK0812
16.00Single6H7MSalbutamol6H7M-β1-Salbutamol
16.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
16.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
16.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
16.00Single6PS1Timolol6PS1-β2-Timolol
16.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
16.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
16.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
16.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
16.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
16.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
16.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
16.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
16.00Single8CU6LJ-45178CU6-A2A-LJ-4517
16.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
16.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
16.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
16.00Single8GGNEpinephrine8GGN-β2-Epinephrine
16.00Single8GGOEpinephrine8GGO-β2-Epinephrine
16.00Single8GGUEpinephrine8GGU-β2-Epinephrine
16.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
16.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
16.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
16.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
16.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
16.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
16.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
16.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
16.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
16.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
16.00Consensuscck_offOrthosteric Ligandccka_off
16.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
16.00Consensushcar_offOrthosteric Ligandsuccinate_off
16.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.79Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.62Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
15.38Single2Y03Isoprenaline2Y03-β1-Isoprenaline
15.38Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
15.38Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.38Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
15.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.38Single5WIUNemonapride5WIU-D4-Nemonapride
15.38Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.38Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
15.38Single6E67BI1671076E67-β2-BI167107-Gs (fused)
15.38Single6GPXMK08126GPX-CCR2-MK0812
15.38Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
15.38Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
15.38Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.38Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
15.38Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.38Single6Z4SSR486926Z4S-NTS1-SR48692
15.38Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
15.38Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
15.38Single7C4SS1P7C4S-S1P3-S1P
15.38Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
15.38Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
15.38Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
15.38Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
15.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
15.38Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.38Single7WC6LSD7WC6-5-HT2A-LSD
15.38Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
15.38Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.38Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
15.38Single8QOTNanobody E8QOT-μ-Nanobody E
15.38Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
15.38Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
15.38Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
15.38Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
15.38Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
15.38Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
15.38Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
15.38Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.38Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
15.38Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
15.38Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
15.38Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
15.38Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
15.15Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
15.15Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
15.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
15.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
15.00Single8PWNTheophylline8PWN-A2A-Theophylline
14.81Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
14.81Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
14.81Single4DJHJDTic4DJH-κ-JDTic
14.81Single4U15Tiotropium4U15-M3-Tiotropium
14.81Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
14.81Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
14.81Single5TZR-5TZR-FFA1 (GPR40)-MK8666
14.81Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.81Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.81Single6H7JIsoprenaline6H7J-β1-Isoprenaline
14.81Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.81Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
14.81Single6OL9Tiotropium6OL9-M5-Tiotropium
14.81Single6TQ7SB-3348676TQ7-OX1-SB-334867
14.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.81Single6WGTLSD6WGT-5-HT2A-LSD
14.81Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.81Single7B6WCyclazosin7B6W-α1b-Cyclazosin
14.81Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
14.81Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
14.81Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
14.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
14.81Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.81Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
14.81Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
14.81Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
14.81Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
14.81Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.81Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
14.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
14.81Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
14.81Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
14.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
14.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
14.81Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
14.81Consensus5ht5_offOrthosteric Ligand5ht5a_off
14.81Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
14.81Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
14.81Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
14.81Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
14.81Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
14.81Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.81Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
14.81Consensushistamine_offOrthosteric Ligandh1_off
14.81Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
14.81Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
14.81Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.81Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
14.81Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.81Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
14.81Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
14.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.71Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.63Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.63Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single5CXVTiotropium5CXV-M1-Tiotropium
14.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
14.29Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
14.29Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
14.29Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
14.29Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
14.29Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
14.29Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
14.29Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.29Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
14.29Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
14.29Consensusclass-b2_onOrthosteric Ligandadgrg_on
14.29Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
14.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.29Consensussensory_onOrthosteric Ligandopsin_on
13.95Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.89Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.89Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.79Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
13.79Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.79Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
13.79Single7UM4AS26747237UM4-5-HT5A-AS2674723
13.79Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
13.79Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
13.79Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.79Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.79Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.79Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.64Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.64Single3OE8IT1t3OE8-CXCR4-IT1t
13.64Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
13.64Single3UZAGTPL92363UZA-A2A-GTPL9236
13.64Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.64Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
13.64Single6ME9Ramelteon6ME9-MT2-Ramelteon
13.64Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
13.64Single7WC5Psilocin7WC5-5-HT2A-Psilocin
13.64Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8GGREpinephrine8GGR-β2-Epinephrine
13.64Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.64Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
13.64Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
13.64Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.64Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
13.51Single6LMLGlucagon6LML-Glucagon-Glucagon
13.51Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
13.51Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.51Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single5EE7MK08935EE7-Glucagon-MK0893
13.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.16Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.04Single3PBLEticlopride3PBL-D3-Eticlopride
13.04Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
13.04Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
13.04Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.04Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.04Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.04Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.04Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
13.04Single7UL2SR486927UL2-NTS1-SR48692-Na
13.04Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.04Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
13.04Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
13.04Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
13.04Single8GGSEpinephrine8GGS-β2-Epinephrine
13.04Single8GH1Epinephrine8GH1-β2-Epinephrine
13.04Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.04Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
13.04Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusclass-t_onOrthosteric Ligandtaste2_on
13.04Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
13.04Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.04Consensusgs_class-tOrthosteric Ligandgs_taste
13.04Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.04Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
13.04Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.04Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.04Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.90Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.90Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
12.90Single7QA8Peptide7QA8-STE2-Peptide
12.90Single7QA8Peptide7QA8-STE2-Peptide
12.90Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.90Consensusclass-d_offOrthosteric Ligandste2_off
12.82Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.82Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.50Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
12.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
12.50Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single6B73PubChem 1319551386B73-κ-PubChem 131955138
12.50Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
12.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.50Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
12.50Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
12.50Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
12.50Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
12.50Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
12.50Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
12.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
12.50Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IWESpermidine8IWE-TAAR9-Spermidine
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
12.50Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
12.50Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
12.50Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
12.50Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
12.50Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
12.50Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
12.50Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.20Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.20Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.20Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
12.12Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.12Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
12.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.00Single6IQLL7458706IQL-D4-L745870
12.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
12.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
12.00Single6VI4JDTic6VI4-κ-JDTic
12.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
12.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
12.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
12.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
12.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
12.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
12.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
12.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
12.00Single7VV6C48/807VV6-MRGPRX2-C48/80
12.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
12.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
12.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
12.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.00Single8GGKEpinephrine8GGK-β2-Epinephrine
12.00Single8GGMEpinephrine8GGM-β2-Epinephrine
12.00Single8GGPEpinephrine8GGP-β2-Epinephrine
12.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
12.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
12.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
12.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
12.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
12.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
12.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
12.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
12.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
12.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
12.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
12.00Consensussensory_offOrthosteric Ligandopsin_off
11.90Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.90Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.76Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
11.54Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
11.54Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.54Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
11.54Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
11.54Single5DSGTiotropium5DSG-M4-Tiotropium
11.54Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
11.54Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
11.54Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
11.54Single6DRXLisuride6DRX-5-HT2B-Lisuride
11.54Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
11.54Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
11.54Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
11.54Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
11.54Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.54Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
11.54Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
11.54Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
11.54Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.54Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.54Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
11.54Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
11.54Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
11.54Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.54Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
11.54Single8JJOAlprenolol8JJO-β2-Alprenolol
11.54Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
11.54Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.54Single8X64Desloratadine8X64-H1-Desloratadine
11.54Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
11.54Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
11.54Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
11.54Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
11.54Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.54Consensushistamine_onOrthosteric Ligandh1_on h4_on
11.54Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.54Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.54Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.43Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
11.43Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.11Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
11.11Single5CGCHTL142425CGC-mGlu5-HTL14242
11.11Single5TVNLSD5TVN-5-HT2B-LSD
11.11Single5XPRBosentan5XPR-ETB-Bosentan
11.11Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
11.11Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
11.11Single6LUQHaloperidol6LUQ-D2-Haloperidol
11.11Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.11Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6PS6Timolol6PS6-β2-Timolol
11.11Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.11Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
11.11Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.11Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
11.11Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
11.11Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
11.11Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
11.11Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
11.11Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
11.11Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
11.11Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.11Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
11.11Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
11.11Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.87Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.87Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.81Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
10.81Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.81Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
10.81Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
10.71Single5V54Methiothepin5V54-5-HT1B-Methiothepin
10.71Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
10.71Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.71Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
10.71Single7W41PD1762527W41-BB2-PD176252
10.71Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
10.71Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
10.71Consensus5ht1_offOrthosteric Ligand5ht1b_off
10.71Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
10.71Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
10.71Consensusbombesin_offOrthosteric Ligandbb2_off
10.71Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
10.71Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
10.53Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.53Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
10.53Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
10.53Single8HS2Fab0468HS2-GPR20-Fab046
10.53Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
10.34Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.34Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
10.34Single6HLPNetupitant6HLP-NK1-Netupitant
10.34Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.34Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
10.34Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
10.26Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
10.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.00Single5CGDHTL142425CGD-mGlu5-HTL14242
10.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
10.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
9.68Consensusclass-d_offOrthosteric Ligandste2_off
9.68Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusgs_class-b2Orthosteric Ligandgs_adgr
9.68Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
9.52Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
9.52Single7WC4Serotonin7WC4-5-HT2A-Serotonin
9.52Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
9.52Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.38Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
9.09Single6TQ9SB-4081246TQ9-OX1-SB-408124
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
9.09Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
9.09Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
8.70Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.70Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.70Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
8.70Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
8.70Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
8.70Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
8.70Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
8.70Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.57Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.57Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.57Consensusclass-d_onOrthosteric Ligandste2_on
8.57Consensusgi_class-dOrthosteric Ligandgi_ste
8.57Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.57Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
8.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
8.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
8.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
8.33Single6HLLCP999946HLL-NK1-CP99994
8.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
8.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
8.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7SRQLSD7SRQ-5-HT2B-LSD
8.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.33Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
8.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
8.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
8.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
8.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
8.33Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
8.33Consensusgo_class-b2Orthosteric Ligandgo_adhesion
8.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
8.16Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
8.11Consensusclass-d_onOrthosteric Ligandste2_on
8.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.00Single5DHHSB-6121115DHH-NOP-SB-612111
8.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
8.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
8.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
8.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
8.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
8.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
8.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
8.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
8.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
8.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
8.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
8.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
7.89Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
7.89Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.89Consensusgi_class-dOrthosteric Ligandgi_ste
7.89Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.69Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
7.69Single6A94Zotepine6A94-5-HT2A-Zotepine
7.69Single6FFIMMPEP6FFI-mGlu5-MMPEP
7.69Single6TPNHTL66416TPN-OX2-HTL6641
7.69Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
7.69Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
7.69Single7VODCariprazine7VOD-5-HT2A-Cariprazine
7.69Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
7.69Single8GGLEpinephrine8GGL-β2-Epinephrine
7.69Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
7.69Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
7.69Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
7.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
7.50Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
7.41Single4DAJTiotropium4DAJ-M3-Tiotropium
7.41Single4MQSIperoxo4MQS-M2-Iperoxo
7.41Single4U14Tiotropium4U14-M3-Tiotropium
7.41Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
7.41Single6FFHFenobam6FFH-mGlu5-Fenobam
7.41Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
7.41Single7F83PF-051904577F83-Ghrelin-PF-05190457
7.41Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
7.41Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
7.41Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
7.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.41Single8X63Mepyramine8X63-H1-Mepyramine
7.41Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
7.41Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.41Consensustachykinin_offOrthosteric Ligandnk1_off
7.14Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
7.14Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
7.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
7.14Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
7.14Single8EA0Iperoxo8EA0-M3-Iperoxo
7.14Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.90Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.90Single6E59L-7607356E59-NK1-L-760735
6.90Single6J20Aprepitant6J20-NK1-Aprepitant
6.90Single7EPENAM5637EPE-mGlu-NAM563
6.90Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
6.90Single7P2L4YI7P2L-mGlu5-4YI
6.90Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
6.90Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.90Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.90Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.90Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
6.90Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
6.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.45Single6K1QIRL25006K1Q-ETB-IRL2500
6.45Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
6.25Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6D35Cholesterol6D35-SMO-Cholesterol
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.56Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.56Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.56Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
5.56Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.56Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
5.56Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.56Single7DTTCa7DTT-CaS-Ca-Ca
5.56Single7DTTCa7DTT-CaS-Ca-Ca
5.56Single7DTUTryptophan7DTU-CaS-Tryptophan
5.56Single7DTUTryptophan7DTU-CaS-Tryptophan
5.56Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
5.56Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
5.56Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7FIIhCG7FII-LH-hCG-6fuf
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.56Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
5.56Single7XW7K1-707XW7-TSH-K1-70
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.56Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.56Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.56Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
5.56Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.56Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
5.56Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.56Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.56Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.56Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
5.56Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.56Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusgphr_onOrthosteric Ligandlh_on tsh_on
5.56Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Consensusgs_proteinOrthosteric Ligandgs_gphr
5.56Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
5.56Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.56Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
5.56Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.56Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.56Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
5.56Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.56Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
5.56Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.56Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
5.56Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.56Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
5.56Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.56Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.56Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.26Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.26Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
5.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.88Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.76Single6W25Ca6W25-MC4-SHU9119-Ca
4.76Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.76Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.76Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.76Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.76Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single5L7DCholesterol5L7D-SMO-Cholesterol
4.55Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.55Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
4.55Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.35Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
4.17Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
4.17Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
4.17Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
4.17Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
4.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
4.00Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
3.85Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.70Single3RZECidoxepin3RZE-H1-Cidoxepin
3.70Single6TPKRetosiban6TPK-OT-Retosiban
3.70Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.70Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.70Consensusvasopressin-ot_offOrthosteric Ligandot_off
3.57Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
3.45Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.45Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885

PDB Summary
PDB 7C6A
Class A
SubFamily Peptide
Type Angiotensin
SubType AT2
Species Homo sapiens
Ligand (Sar1,Ile8)-Angiotensin II
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.4
Date 2020-07-29
D.O.I. 10.1038/s41598-020-68355-x
Net Summary
Imin 3.44
Number of Linked Nodes 275
Number of Links 316
Number of Hubs 46
Number of Links mediated by Hubs 167
Number of Communities 9
Number of Nodes involved in Communities 54
Number of Links involved in Communities 71
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 62153
Length Of Smallest Path 3
Average Path Length 11.8398
Length of Longest Path 25
Minimum Path Strength 1.27
Average Path Strength 6.19061
Maximum Path Strength 15.11
Minimum Path Correlation 0.7
Average Path Correlation 0.924847
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 52.24
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.8355
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSAR
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeSAR
NameSarcosine
SynonymsSarcosine
Identifier2-(methylamino)ethanoic acid
FormulaC3 H7 N O2
Molecular Weight89.093
SMILESCNCC(=O)O
PubChem7311726
Formal Charge0
Total Atoms13
Total Chiral Atoms0
Total Bonds12
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP50052
Sequence
>7C6A_Chain_R
CSQKPSDKH LDAIPILYY IIFVIGFLV NIVVVTLFC CQKGPKKVS 
SIYIFNLAV ADLLVLATL PLWATYYSY RYDWLFGPV MCKVFGSFL 
TLNMFASIW FITCMSVDR YQSVIYPFN PWQASYIVP LVWCMACLS 
SLPTFYFRD VRTIEYLGV NACIMAFPP EKYAQWSAG IALMKNILG 
FIIPLIFIA TCYFGIRKH LLKTNKNRI TRDQVLKMA AAVVLAFII 
CWLPFHVLT FLDALAWMG VINSCEVIA VIDLALPFA ILLGFTNSC 
VNPFLYCFV GN


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ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5UNFAPeptideAngiotensinAT2Homo sapiensPubChem 15780052--2.82017-04-0510.1038/nature22035
5UNGAPeptideAngiotensinAT2Homo sapiensPubChem 15780052--2.82017-04-0510.1038/nature22035
5UNHAPeptideAngiotensinAT2Homo sapiensPubChem 126456406--2.92017-04-0510.1038/nature22035
5XJMAPeptideAngiotensinAT2Homo sapiens(Sar1,Ile8)-Angiotensin II--3.22018-07-1110.1038/s41594-018-0079-8
6JODAPeptideAngiotensinAT2Homo sapiensAngiotensin II--3.22020-01-1510.1016/j.str.2019.12.003
7JNIAPeptideAngiotensinAT2Homo sapiensOlodanrigan--32022-02-0910.1073/pnas.2116289119




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Download 7C6A.zip



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