Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1T:T:V64 5.2175429
2T:T:S69 3.6825429
3T:T:D73 5.09528
4T:T:Y74 5.7925429
5T:T:L81 3.87408
6T:T:F85 3.9465188
7T:T:S86 3.9185139
8T:T:E95 11.045428
9T:T:I98 2.35408
10T:T:L106 6.26254249
11T:T:Y118 6.2125899
12T:T:W120 5.368509
13T:T:R145 5.375249
14T:T:R149 7.91254249
15T:T:T152 4.1409
16T:T:F156 4.811437139
17T:T:D157 6.7765199
18T:T:E160 7.114199
19T:T:N161 5.18254299
20T:T:R178 6.9925409
21T:T:P179 5.115409
22T:T:V181 2.734189
23T:T:Y182 6.1625139
24T:T:R202 5.84833629
25T:T:R204 8.90857729
26T:T:I205 3.26754189
27T:T:H207 4.09409
28T:T:F217 8.8154109
29T:T:I221 4.5425419
30R:R:R40 6.214303
31R:R:V41 3.9075407
32R:R:P52 3.75833678
33R:R:L62 3.9025475
34R:R:I64 4.38429776
35R:R:N67 4.762579
36R:R:L72 3.184317
37R:R:F77 3.56667607
38R:R:F80 4.035407
39R:R:L83 2.6875479
40R:R:L86 4.506578
41R:R:L88 5.2425409
42R:R:I96 3.25754319
43R:R:H97 9.384328
44R:R:L110 4.4975409
45R:R:L112 4.1525409
46R:R:Q113 6.47667629
47R:R:N114 5.692529
48R:R:V120 3.722557
49R:R:L134 4.4975409
50R:R:R135 13.8075429
51R:R:L136 3.934559
52R:R:D137 7.556529
53R:R:N139 3.7825459
54R:R:I141 4.3125459
55R:R:V144 4.754559
56R:R:S148 4.4725458
57R:R:F149 3.26286709
58R:R:H157 5.426529
59R:R:L158 4.0525119
60R:R:W159 8.59333629
61R:R:D161 5.8225429
62R:R:V168 3.1075408
63R:R:P169 4.4875459
64R:R:L176 3.66254119
65R:R:L179 3.693336119
66R:R:L182 4.7065118
67R:R:T183 5.4429
68R:R:I192 3.278518
69R:R:F195 3.87482
70R:R:F197 3.32857709
71R:R:L203 3.3225119
72R:R:V205 3.73529
73R:R:L206 3.498509
74R:R:H207 7.126529
75R:R:L208 3.4925409
76R:R:H209 8.872529
77R:R:N210 7.545409
78R:R:N211 4.18419
79R:R:I213 4.05667619
80R:R:L216 3.2675416
81R:R:H219 7.0975485
82R:R:C220 4.294515
83R:R:F221 6.295409
84R:R:L227 3.46254119
85R:R:L230 4.018509
86R:R:L232 3.455419
87R:R:Y234 9.5275426
88R:R:N235 4.162519
89R:R:L237 4.475418
90R:R:F240 4.945819
91R:R:I244 2.81418
92R:R:L247 4.66409
93R:R:L250 5.865409
94R:R:E252 6.43429
95R:R:L253 5.51409
96R:R:F255 4.59619
97R:R:H256 14.444529
98R:R:N258 5.0525419
99R:R:F268 3.57333919
100R:R:N271 4.22419
101R:R:I277 3.686518
102R:R:V287 2.285409
103R:R:G288 2.9575409
104R:R:N289 3.35254164
105R:R:F292 5.1619
106R:R:L301 6.2025419
107R:R:R304 4.5925448
108R:R:F312 6.51618
109R:R:L315 3.765419
110R:R:L324 4.362519
111R:R:L326 4.976517
112R:R:T327 4.4125449
113R:R:I334 5.028517
114R:R:L348 3.81509
115R:R:D349 6.1975448
116R:R:L350 4.065619
117R:R:S351 6.0275449
118R:R:N353 3.5375419
119R:R:I355 4.3075418
120R:R:L358 5.0925418
121R:R:F361 3.045616
122R:R:L367 4.6625417
123R:R:I370 3.64517
124R:R:L372 3.155418
125R:R:Q373 6.748548
126R:R:N375 3.825419
127R:R:I377 6.0425417
128R:R:Y378 8.164341
129R:R:I380 2.635417
130R:R:T384 4.5175408
131R:R:F385 4.64167619
132R:R:L391 3.8375419
133R:R:L394 5.044517
134R:R:D395 8.1625449
135R:R:L396 3.7775419
136R:R:S397 5.022548
137R:R:N399 4.8775419
138R:R:I401 4.655418
139R:R:I404 3.71517
140R:R:R407 6.584204
141R:R:F409 3.196508
142R:R:L412 4.875408
143R:R:L418 4.3725419
144R:R:D419 8.0725449
145R:R:V420 2.89416
146R:R:L425 5.17419
147R:R:F428 4.604514
148R:R:L436 4.175418
149R:R:Q438 6.7354359
150R:R:L439 4.40429718
151R:R:D455 5.9875414
152R:R:F456 4.41333615
153R:R:L459 4.2625417
154R:R:L462 4.385417
155R:R:V464 4.346517
156R:R:P465 6.615419
157R:R:Y466 6.16616
158R:R:Y468 7.19167619
159R:R:Q469 7.625419
160R:R:F473 4.5475408
161R:R:F529 3.515408
162R:R:Y534 7.398514
163R:R:L535 5.65519
164R:R:L536 6.242515
165R:R:M540 5.3025415
166R:R:R542 6.47167619
167R:R:W546 6.412519
168R:R:F549 4.96167615
169R:R:F555 3.59535
170R:R:K574 4.25537
171R:R:F576 4.1275406
172R:R:M587 4.6575466
173R:R:Y590 7.65405
174R:R:F605 5.87619
175R:R:F608 5.02404
176R:R:W612 5.193336219
177R:R:A621 2.7054215
178R:R:F623 2.4565124
179R:R:F627 4.5945125
180R:R:E630 7.244368
181R:R:L635 4.154125
182R:R:R643 5.666508
183R:R:H658 4.964384
184R:R:F670 4.3625123
185R:R:G677 2.6675408
186R:R:P680 7.034567
187R:R:Y687 7.7275405
188R:R:P691 4.46833619
189R:R:C693 4.51754219
190R:R:L694 4.7075467
191R:R:P695 3.156569
192R:R:F696 4.59467
193R:R:F706 6.5125465
194R:R:V708 1.9125409
195R:R:N714 7.58254369
196R:R:F718 4.525376
197R:R:Y725 5.4456268
198R:R:L728 4.184269
199R:R:M745 4.595437
200R:R:H748 6.22833639
201R:R:F759 6.4185149
202R:R:F760 5.65408
203R:R:F766 6.745109
204R:R:I777 4.53754106
205R:R:S778 7.3254106
206R:R:E780 8.885108
207R:R:I781 3.9245108
208R:R:L787 4.225419
209R:R:I788 4.64254147
210R:R:F789 5.80254147
211R:R:F790 5.216565
212R:R:P791 3.288569
213R:R:Y801 5.5739
214R:R:F803 2.414537
215R:R:N805 5.50167638
216R:R:K807 4.615436
217R:R:F808 4.84537
218R:R:L815 2.595407
219L:L:D49 7.9375426
220L:L:N50 6.51667629
221L:L:K58 6.605428
222L:L:F60 5.376529
223L:L:F61 4.00667627
224L:L:F62 6.922526
225L:L:L63 5.22429
226L:L:R65 7.455429
227L:L:Q70 7.0975428
228L:L:Y71 8.3725426
229L:L:H76 7.91407
230L:L:C78 3.992529
231L:L:P79 5.18429
232L:L:Y82 7.01167628
233L:L:R86 5.72625829
234L:L:C93 4.324529
235L:L:R97 6.565425
236L:L:N100 11.635408
237L:L:F105 6.92833629
238L:L:F109 5.63728
239L:L:C110 4.00254229
240L:L:Y118 5.8445155
241L:L:H120 7.2375405
242L:L:R121 4.7925405
243L:L:C128 5.38254159
244L:L:P129 2.78754159
245L:L:L135 7.31754255
246L:L:C141 4.0354159
247E:E:V64 5.01499
248E:E:F66 6.3075499
249E:E:Y74 5.4975499
250E:E:L81 5.3025408
251E:E:F85 4.516676178
252E:E:S86 4.2185239
253E:E:E95 9.985408
254E:E:Q100 3427
255E:E:M101 3.57167629
256E:E:H102 5.65571729
257E:E:E113 2.92529
258E:E:Y116 6.13667629
259E:E:Y118 6.34125829
260E:E:W120 4.65167629
261E:E:V121 3.3475409
262E:E:V123 3.04409
263E:E:K125 8.3409
264E:E:C136 3.82409
265E:E:R145 6.176529
266E:E:R149 6.14429
267E:E:T152 5.468529
268E:E:F156 5.2056429
269E:E:D157 7.8175409
270E:E:V158 4.0854239
271E:E:N161 4.24409
272E:E:I165 5.894239
273E:E:N169 4.1554239
274E:E:P179 4.2875409
275E:E:V181 2.734179
276E:E:Y182 7.7925239
277E:E:M192 4.532529
278E:E:N196 3.7225429
279E:E:R202 6.522599
280E:E:R204 10.295499
281H:H:?3 12.424160
282H:H:?4 11.0165160
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1T:T:S86 T:T:Y182 11.93232.54YesYes1399
2T:T:L168 T:T:S86 15.90967.51NoYes1399
3T:T:F156 T:T:L168 16.90352.44YesNo1399
4T:T:F156 T:T:L126 52.63514.87YesNo099
5T:T:L126 T:T:N161 53.62782.75NoYes099
6T:T:N161 T:T:P129 56.60658.15YesNo099
7T:T:P129 T:T:Q128 58.59234.74NoNo099
8T:T:E160 T:T:Q128 59.58523.82YesNo099
9T:T:D157 T:T:E160 60.57385.2YesYes1999
10T:T:A188 T:T:D157 70.50616.18NoYes099
11T:T:A188 T:T:V183 71.49921.7NoNo099
12T:T:S86 T:T:V180 15.90964.85YesNo099
13T:T:F156 T:T:V180 19.88662.62YesNo099
14T:T:I155 T:T:V183 73.4563.07NoNo099
15T:T:I155 T:T:V121 77.43463.07NoNo099
16T:T:G96 T:T:V121 87.35741.84NoNo089
17T:T:G96 T:T:R202 96.40683NoYes089
18T:T:R202 T:T:R204 48.46393.2YesYes299
19T:T:E62 T:T:Q206 11.92328.92NoNo099
20R:R:R460 T:T:E62 12.36479.3NoNo099
21E:E:Y118 T:T:R202 49.23934.12YesYes299
22T:T:R204 T:T:V64 1009.15YesYes299
23E:E:Y118 T:T:V64 1003.79YesYes299
24T:T:T78 T:T:V64 1003.17NoYes099
25R:R:N437 T:T:T78 1004.39NoNo059
26R:R:N437 R:R:T416 1005.85NoNo2754
27R:R:N417 R:R:T416 1005.85NoNo074
28E:E:G150 E:E:Y118 1002.9NoYes299
29E:E:G150 E:E:W120 1002.81NoYes299
30E:E:M101 E:E:W120 60.47383.49YesYes299
31E:E:L106 E:E:M101 10.5072.83NoYes099
32E:E:W120 E:E:Y116 1004.82YesYes299
33T:T:N169 T:T:R87 11.93254.82NoNo095
34T:T:M101 T:T:W120 12.10352.33NoYes099
35T:T:L106 T:T:M101 14.11247.07YesNo099
36T:T:L106 T:T:R145 12.07964.86YesYes2499
37T:T:L106 T:T:R149 12.0776.07YesYes2499
38T:T:D111 T:T:R145 18.104511.91NoYes2499
39T:T:D111 T:T:R149 21.13911.91NoYes2499
40E:E:G72 T:T:D111 40.24695.03NoNo099
41E:E:Y74 T:T:L115 49.27712.34YesNo098
42E:E:G72 T:T:L115 48.27371.71NoNo098
43E:E:Y74 T:T:Y118 51.28258.94YesYes999
44E:E:R202 T:T:Y118 27.14494.12YesYes999
45E:E:R204 T:T:Y118 26.99995.14YesYes999
46E:E:R178 T:T:R204 38.59218.13NoYes299
47R:R:N417 R:R:Q438 10013.2NoYes079
48R:R:K440 R:R:Q438 1008.14NoYes089
49R:R:D419 R:R:K440 10011.06YesNo098
50R:R:D395 R:R:D419 1007.98YesYes499
51R:R:D395 R:R:S371 1004.42YesNo496
52R:R:D349 R:R:S371 1005.89YesNo486
53R:R:D349 R:R:T327 1004.34YesYes489
54R:R:G328 R:R:T327 1003.64NoYes079
55R:R:G328 R:R:T329 1001.82NoNo078
56R:R:N353 R:R:T329 1005.85YesNo098
57R:R:L350 R:R:N353 1002.75YesYes199
58R:R:L348 R:R:L350 1006.92YesYes099
59R:R:F361 R:R:L348 1002.44YesYes069
60R:R:F361 R:R:I370 55.79972.51YesYes167
61R:R:I370 R:R:L394 1002.85YesYes177
62R:R:L394 R:R:L418 1004.15YesYes179
63R:R:L418 R:R:L439 1004.15YesYes198
64R:R:L439 R:R:L462 1004.15YesYes187
65R:R:L462 R:R:V464 1002.98YesYes177
66R:R:D395 R:R:Q373 10014.36YesYes498
67R:R:Q373 R:R:S351 1008.66YesYes489
68R:R:S351 R:R:T327 1003.2YesYes499
69R:R:D419 R:R:S397 1007.36YesYes498
70R:R:Q373 R:R:S397 1004.33YesYes488
71R:R:N353 R:R:N375 1002.72YesYes199
72R:R:I377 R:R:N375 1002.83YesYes179
73R:R:I377 R:R:L372 1002.85YesYes178
74R:R:I370 R:R:L372 47.14992.85YesYes178
75R:R:F361 R:R:F385 1003.22YesYes169
76R:R:F385 R:R:L394 55.94548.53YesYes197
77R:R:L372 R:R:L396 1002.77YesYes189
78R:R:L394 R:R:L396 47.05226.92YesYes179
79R:R:F385 R:R:F409 56.32452.14YesYes098
80R:R:F409 R:R:L418 55.98563.65YesYes089
81R:R:L396 R:R:V420 94.06392.98YesYes196
82R:R:F428 R:R:V420 47.03472.62YesYes146
83R:R:F428 R:R:L439 1003.65YesYes148
84R:R:N375 R:R:N399 1004.09YesYes199
85R:R:I401 R:R:N399 93.95462.83YesYes189
86R:R:I401 R:R:I404 93.92472.94YesYes187
87R:R:I404 R:R:L425 46.9884.28YesYes179
88R:R:F428 R:R:L425 93.92332.44YesYes149
89R:R:N399 R:R:N423 46.97494.09YesNo199
90R:R:N423 R:R:N444 46.96572.72NoNo099
91R:R:L425 R:R:N444 46.95710.98YesNo099
92R:R:I404 R:R:P429 46.99176.77YesNo079
93R:R:F428 R:R:P429 46.98865.78YesNo049
94R:R:L441 R:R:V420 47.03472.98NoYes186
95R:R:L439 R:R:L441 47.02856.92YesNo188
96R:R:P465 R:R:V464 1003.53YesYes197
97R:R:P465 R:R:Y466 1006.95YesYes196
98R:R:I610 R:R:Y466 1006.04NoYes176
99R:R:I610 R:R:Y468 1006.04NoYes179
100R:R:P691 R:R:Y468 1004.17YesYes199
101R:R:P691 R:R:S690 1005.34YesNo098
102R:R:F529 R:R:S690 10.80793.96YesNo088
103R:R:F529 R:R:M782 10.03553.73YesNo085
104R:R:Q469 R:R:V464 10010.03YesYes197
105R:R:Q469 R:R:Y466 1006.76YesYes196
106R:R:I541 T:T:I221 10.39364.42NoYes179
107R:R:I541 R:R:L787 12.70262.85NoYes179
108R:R:L692 R:R:S690 1004.5NoNo078
109R:R:L535 R:R:L536 1004.15YesYes195
110R:R:L535 R:R:P691 1003.28YesYes199
111R:R:F605 R:R:L535 1008.53YesYes199
112R:R:F605 R:R:Y468 1004.13YesYes199
113R:R:F789 R:R:L792 13.4443.65YesNo1479
114R:R:I548 R:R:L792 26.88812.85NoNo079
115R:R:I548 R:R:P791 1003.39NoYes079
116R:R:P791 R:R:T591 1003.5YesNo097
117R:R:F549 R:R:T591 1003.89YesNo057
118R:R:F549 R:R:W546 1003.01YesYes159
119R:R:R542 R:R:W546 1002YesYes199
120R:R:L536 R:R:R542 1003.64YesYes159
121R:R:D598 R:R:R542 10013.1NoYes199
122R:R:D598 R:R:L535 1008.14NoYes199
123R:R:F790 R:R:P791 48.85724.33YesYes659
124R:R:F790 R:R:L694 90.73.65YesYes657
125R:R:L694 R:R:Y590 98.35327.03YesYes075
126R:R:L594 R:R:Y590 99.109612.89NoYes095
127R:R:L594 R:R:L692 99.4922.77NoNo097
128R:R:C795 R:R:I548 80.65939.82NoNo097
129R:R:C795 R:R:V551 78.74033.42NoNo096
130R:R:F549 R:R:L553 64.49936.09YesNo055
131R:R:L553 R:R:L557 62.96322.77NoNo053
132R:R:L557 R:R:L585 61.42732.77NoNo034
133R:R:L585 R:R:N556 59.89345.49NoNo049
134R:R:N556 R:R:P798 58.36366.52NoNo099
135R:R:F555 R:R:P798 56.8282.89YesNo059
136R:R:F555 R:R:F803 27.6512.14YesYes357
137R:R:F803 R:R:F804 13.82762.14YesNo079
138R:R:F804 T:T:V238 10.37111.31NoNo098
139R:R:F555 R:R:V551 71.06563.93YesNo056
140R:R:H748 R:R:N805 13.82723.83YesYes398
141R:R:H748 R:R:L752 10015.43YesNo099
142R:R:L752 R:R:N797 1006.87NoNo099
143R:R:N584 R:R:N797 1002.72NoNo099
144R:R:A794 R:R:N584 1004.69NoNo089
145R:R:A794 R:R:M587 26.56163.22NoYes686
146R:R:F790 R:R:M587 28.46787.46YesYes656
147R:R:A794 R:R:P791 1001.87NoYes689
148R:R:L110 R:R:L86 10.55424.15YesYes098
149R:R:L110 R:R:L134 13.30914.15YesYes099
150R:R:L134 R:R:L158 16.16394.15YesYes099
151R:R:L158 R:R:L182 20.11854.15YesYes1198
152R:R:L182 R:R:L206 24.07914.15YesYes089
153R:R:L206 R:R:L230 29.464.15YesYes099
154R:R:L230 R:R:L253 37.49594.15YesYes099
155R:R:F268 R:R:L253 38.17152.44YesYes099
156R:R:F268 R:R:F292 41.28085.36YesYes199
157R:R:F292 R:R:L301 33.892412.18YesYes199
158R:R:L301 R:R:L324 33.97984.15YesYes199
159R:R:F312 R:R:I331 19.23233.77YesNo088
160R:R:I331 R:R:T329 19.15034.56NoNo088
161R:R:I64 R:R:L88 10.01998.56YesYes069
162R:R:L112 R:R:L88 14.11392.77YesYes099
163R:R:L112 R:R:L136 12.28174.15YesYes099
164R:R:L136 R:R:L160 10.22472.77YesNo099
165R:R:F292 R:R:I303 18.92123.77YesNo198
166R:R:I303 R:R:L326 19.04844.28NoYes187
167R:R:E85 R:R:R40 11.95765.82NoYes3083
168R:R:E85 R:R:Q87 17.93647.65NoNo088
169R:R:Q87 R:R:T111 32.88325.67NoNo089
170R:R:Q113 R:R:T111 23.9014.25YesNo299
171R:R:N114 R:R:Q113 14.98152.64YesYes299
172L:L:R86 R:R:N114 42.87112.41YesYes299
173L:L:F60 L:L:R86 10011.76YesYes299
174L:L:C78 L:L:F60 65.16024.19YesYes299
175L:L:C78 L:L:Y82 66.15452.69YesYes298
176E:E:E113 L:L:Y82 1002.24YesYes298
177E:E:D114 E:E:E113 1002.6NoYes299
178E:E:D114 E:E:Y116 10014.94NoYes299
179R:R:D137 R:R:Q113 14.96687.83YesYes299
180L:L:R86 R:R:D137 64.76274.76YesYes299
181R:R:R135 R:R:T111 11.97157.76YesNo299
182R:R:D137 R:R:R135 12.948514.29YesYes299
183L:L:C93 L:L:F60 65.28042.79YesYes299
184L:L:C93 L:L:Y82 65.65342.69YesYes298
185R:R:H157 R:R:R156 15.96584.51YesNo099
186R:R:H157 R:R:W159 30.94173.17YesYes299
187R:R:D137 R:R:W159 35.91825.58YesYes299
188R:R:D42 R:R:D63 11.9555.32NoNo099
189L:L:H76 R:R:N114 13.98218.93YesYes079
190R:R:D63 R:R:Q87 11.958610.44NoNo098
191L:L:K58 R:R:H140 15.98883.93YesNo088
192L:L:K58 R:R:N114 13.00449.79YesYes289
193L:L:K58 R:R:A138 12.97663.21YesNo289
194L:L:R86 R:R:A138 13.97474.15YesNo299
195L:L:F109 R:R:V205 29.44285.24YesYes289
196R:R:H207 R:R:V205 38.91822.77YesYes299
197R:R:H207 R:R:H209 42.41789.55YesYes299
198L:L:H85 R:R:H209 51.42795.97NoYes049
199L:L:H85 L:L:R92 51.92483.39NoNo046
200E:E:N108 L:L:R92 52.22632.41NoNo096
201E:E:E113 E:E:N108 53.2173.94YesNo099
202L:L:T111 R:R:H157 13.96478.21NoYes089
203L:L:F109 R:R:Q180 11.01782.34YesNo089
204L:L:R121 R:R:Q180 10.51715.84YesNo059
205L:L:R121 R:R:V204 10.51923.92YesNo059
206L:L:F109 R:R:V204 17.02836.55YesNo089
207R:R:L535 R:R:L597 68.33884.15YesNo098
208R:R:F555 R:R:L558 51.85032.44YesNo357
209R:R:F555 R:R:V802 44.93746.55YesNo355
210R:R:F808 R:R:L558 41.48196.09YesNo377
211R:R:F808 R:R:V802 41.48625.24YesNo375
212R:R:H748 R:R:Y801 39.19977.62YesYes399
213R:R:T563 R:R:Y801 11.53123.75NoYes349
214R:R:F808 R:R:T562 76.04247.78YesNo075
215R:R:D811 R:R:T562 13.82675.78NoNo095
216R:R:K574 R:R:Y801 16.14552.39YesYes379
217R:R:L815 R:R:T562 55.3072.95YesNo075
218R:R:L815 R:R:R818 34.5671.21YesNo073
219R:R:M745 R:R:S573 80.70013.07YesNo075
220R:R:H748 R:R:M745 87.6083.94YesYes397
221R:R:E642 R:R:R643 20.755612.79NoYes088
222R:R:R643 R:R:S573 76.09912.64YesNo085
223R:R:L579 R:R:L635 12.30068.3NoYes1275
224R:R:F670 R:R:L579 15.37577.31YesNo1237
225R:R:F627 R:R:F670 26.1385.36YesYes1253
226R:R:F623 R:R:F627 33.80013.22YesYes1245
227R:R:F623 R:R:Y687 44.54452.06YesYes045
228R:R:G622 R:R:Y687 61.43327.24NoYes085
229R:R:A621 R:R:G622 31.48951.95YesNo2158
230R:R:A621 R:R:W612 32.25892.59YesYes2159
231R:R:L597 R:R:W612 67.572610.25NoYes089
232R:R:C693 R:R:G622 31.4811.96YesNo2198
233R:R:C693 R:R:W612 32.24865.22YesYes2199
234R:R:P680 R:R:Y687 10.751615.3YesYes075
235R:R:E630 R:R:S629 12.74252.87YesNo088
236R:R:F790 R:R:S629 13.12845.28YesNo058
237R:R:E630 R:R:N714 11.198511.83YesYes3689
238R:R:I746 R:R:R643 20.75535.01NoYes078
239R:R:R643 R:R:V749 11.53072.62YesNo087
240R:R:E642 R:R:F662 16.14339.33NoNo084
241R:R:R643 R:R:S646 20.75565.27YesNo086
242R:R:F662 R:R:H658 11.5312.26NoYes3844
243R:R:I650 R:R:S646 18.44943.1NoNo036
244R:R:I650 R:R:Q742 13.83724.12NoNo037
245R:R:N740 R:R:Q742 11.5317.92NoNo037
246R:R:F759 R:R:L792 11.5248.53YesNo1499
247R:R:R817 R:R:R818 20.74023.2NoNo033
248E:E:H102 L:L:N50 11.47887.65YesYes299
249E:E:H102 L:L:Q70 40.14572.47YesYes298
250E:E:M101 L:L:Q70 45.60214.08YesYes298
251E:E:I155 E:E:V123 20.98613.07NoYes099
252E:E:I155 E:E:V121 11.0683.07NoYes099
253E:E:H102 E:E:P103 22.38719.15YesNo299
254L:L:H120 L:L:R121 19.03326.77YesYes055
255L:L:D102 L:L:K112 10.97164.15NoNo067
256L:L:K112 L:L:T111 12.96693NoNo078
257L:L:C141 L:L:H120 11.01922.95YesYes095
258E:E:S86 E:E:V180 10.4734.85YesNo099
259E:E:F156 E:E:V180 12.46752.62YesNo099
260E:E:F156 E:E:V124 21.44266.55YesNo099
261E:E:P103 E:E:V124 21.9415.3NoNo099
262E:E:F85 E:E:P179 24.24772.89YesYes089
263E:E:P179 E:E:R178 38.09538.65YesNo099
264E:E:L191 E:E:V123 10.93482.98NoYes099
265E:E:K190 E:E:T79 10.41954.5NoNo099
266E:E:K190 E:E:L81 11.90795.64NoYes098
267E:E:F85 E:E:I205 11.40532.51YesNo1789
268E:E:I155 E:E:I205 10.91862.94NoNo099
269E:E:A153 E:E:V121 12.86635.09NoYes099
270E:E:A153 E:E:P179 13.35841.87NoYes099
271R:R:R460 T:T:T78 12.8572.59NoNo099
272T:T:N169 T:T:S86 13.9212.98NoYes1399
273T:T:E95 T:T:R204 67.062813.96YesYes289
274E:E:E95 T:T:E95 66.88173.81YesYes088
275E:E:E95 E:E:R202 30.986716.28YesYes089
276E:E:E95 E:E:R204 31.455612.79YesYes089
277R:R:L324 R:R:L348 25.04044.15YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M66 R:R:S65 3.07 0 No No 9 9 1 2
L:L:H76 R:R:M66 11.82 0 Yes No 7 9 0 1
R:R:A89 R:R:Q113 6.06 0 No Yes 9 9 2 1
L:L:H76 R:R:G90 3.18 0 Yes No 7 9 0 1
R:R:Q113 R:R:T111 4.25 2 Yes No 9 9 1 2
R:R:R135 R:R:T111 7.76 2 Yes No 9 9 2 2
R:R:N114 R:R:Q113 2.64 2 Yes Yes 9 9 1 1
R:R:Q113 R:R:R135 15.19 2 Yes Yes 9 9 1 2
R:R:D137 R:R:Q113 7.83 2 Yes Yes 9 9 1 1
L:L:S77 R:R:Q113 2.89 0 No Yes 7 9 0 1
R:R:A138 R:R:N114 4.69 2 No Yes 9 9 1 1
L:L:K58 R:R:N114 9.79 2 Yes Yes 8 9 0 1
L:L:H76 R:R:N114 8.93 0 Yes Yes 7 9 0 1
L:L:R86 R:R:N114 2.41 2 Yes Yes 9 9 0 1
R:R:H140 R:R:Q116 8.65 0 No No 8 6 1 2
R:R:Q132 R:R:R156 8.18 0 No No 8 9 2 1
R:R:H157 R:R:S133 5.58 2 Yes No 9 9 1 2
R:R:S133 R:R:W159 4.94 2 No Yes 9 9 2 1
R:R:D137 R:R:R135 14.29 2 Yes Yes 9 9 1 2
R:R:R135 R:R:W159 17.99 2 Yes Yes 9 9 2 1
R:R:D137 R:R:W159 5.58 2 Yes Yes 9 9 1 1
R:R:D137 R:R:D161 5.32 2 Yes Yes 9 9 1 1
L:L:R86 R:R:D137 4.76 2 Yes Yes 9 9 0 1
L:L:K58 R:R:A138 3.21 2 Yes No 8 9 0 1
L:L:R86 R:R:A138 4.15 2 Yes No 9 9 0 1
L:L:K58 R:R:H140 3.93 2 Yes No 8 8 0 1
R:R:H157 R:R:R156 4.51 2 Yes No 9 9 1 1
L:L:E140 R:R:R156 4.65 25 No No 8 9 0 1
R:R:H157 R:R:W159 3.17 2 Yes Yes 9 9 1 1
L:L:F109 R:R:H157 5.66 2 Yes Yes 8 9 0 1
L:L:T111 R:R:H157 8.21 0 No Yes 8 9 0 1
R:R:T183 R:R:W159 4.85 2 Yes Yes 9 9 1 1
L:L:F105 R:R:W159 15.03 2 Yes Yes 9 9 0 1
R:R:D161 R:R:T183 10.12 2 Yes Yes 9 9 1 1
R:R:A185 R:R:D161 3.09 0 No Yes 9 9 2 1
L:L:R86 R:R:D161 4.76 2 Yes Yes 9 9 0 1
R:R:D162 R:R:L186 5.43 2 No No 9 9 1 1
L:L:R86 R:R:D162 10.72 2 Yes No 9 9 0 1
L:L:F109 R:R:Q180 2.34 2 Yes No 8 9 0 1
L:L:R121 R:R:Q180 5.84 0 Yes No 5 9 0 1
L:L:F105 R:R:A181 8.32 2 Yes No 9 9 0 1
L:L:F109 R:R:A181 4.16 2 Yes No 8 9 0 1
R:R:H207 R:R:T183 2.74 2 Yes Yes 9 9 1 1
L:L:F105 R:R:T183 3.89 2 Yes Yes 9 9 0 1
R:R:A185 R:R:H209 7.32 0 No Yes 9 9 2 1
R:R:L186 R:R:N210 2.75 2 No Yes 9 9 1 1
L:L:R86 R:R:L186 2.43 2 Yes No 9 9 0 1
L:L:R121 R:R:S202 2.64 0 Yes No 5 8 0 1
R:R:E228 R:R:V204 7.13 0 No No 9 9 2 1
L:L:F109 R:R:V204 6.55 2 Yes No 8 9 0 1
L:L:R121 R:R:V204 3.92 0 Yes No 5 9 0 1
R:R:H207 R:R:V205 2.77 2 Yes Yes 9 9 1 1
R:R:T229 R:R:V205 3.17 2 No Yes 9 9 1 1
L:L:F105 R:R:V205 2.62 2 Yes Yes 9 9 0 1
L:L:S106 R:R:V205 4.85 2 No Yes 8 9 0 1
L:L:F109 R:R:V205 5.24 2 Yes Yes 8 9 0 1
R:R:H207 R:R:H209 9.55 2 Yes Yes 9 9 1 1
R:R:D231 R:R:H207 16.39 2 No Yes 9 9 2 1
L:L:S106 R:R:H207 4.18 2 No Yes 8 9 0 1
R:R:H209 R:R:N210 7.65 2 Yes Yes 9 9 1 1
R:R:D231 R:R:H209 13.87 2 No Yes 9 9 2 1
L:L:H85 R:R:H209 5.97 0 No Yes 4 9 0 1
R:R:N210 R:R:Y234 11.63 0 Yes Yes 9 6 1 2
L:L:P88 R:R:N210 8.15 0 No Yes 5 9 0 1
R:R:E252 R:R:T229 5.64 2 Yes No 9 9 1 1
L:L:D108 R:R:T229 8.67 2 No No 8 9 0 1
R:R:E252 R:R:T276 5.64 2 Yes No 9 8 1 2
L:L:K107 R:R:E252 4.05 0 No Yes 5 9 0 1
L:L:D108 R:R:E252 10.39 2 No Yes 8 9 0 1
E:E:E127 L:L:S47 8.62 2 No No 9 9 1 0
E:E:N196 L:L:K48 2.8 2 Yes No 9 5 1 0
E:E:K125 L:L:D49 8.3 0 Yes Yes 9 6 1 0
E:E:M192 L:L:D49 8.32 2 Yes Yes 9 6 1 0
E:E:N196 L:L:D49 2.69 2 Yes Yes 9 6 1 0
E:E:Q100 L:L:N50 2.64 2 Yes Yes 7 9 1 0
E:E:H102 L:L:N50 7.65 2 Yes Yes 9 9 1 0
E:E:P103 L:L:N50 8.15 2 No Yes 9 9 1 0
E:E:K125 L:L:N50 6.99 0 Yes Yes 9 9 1 0
E:E:E127 L:L:N50 9.2 2 No Yes 9 9 1 0
E:E:H102 L:L:S53 2.79 2 Yes No 9 6 1 0
E:E:E127 L:L:S53 4.31 2 No No 9 6 1 0
E:E:H102 L:L:F61 3.39 2 Yes Yes 9 7 1 0
E:E:L104 L:L:F61 4.87 2 No Yes 9 7 1 0
E:E:H102 L:L:L63 6.43 2 Yes Yes 9 9 1 0
E:E:V99 L:L:R65 3.92 0 No Yes 7 9 1 0
E:E:M101 L:L:R65 2.48 2 Yes Yes 9 9 1 0
E:E:Y116 L:L:R65 8.23 2 Yes Yes 9 9 1 0
E:E:I98 L:L:M68 2.92 0 No No 8 8 1 0
E:E:Q100 L:L:R69 2.34 2 Yes No 7 8 1 0
E:E:N196 L:L:R69 2.41 2 Yes No 9 8 1 0
E:E:M101 L:L:Q70 4.08 2 Yes Yes 9 8 1 0
E:E:H102 L:L:Q70 2.47 2 Yes Yes 9 8 1 0
E:E:E113 L:L:Y82 2.24 2 Yes Yes 9 8 1 0
E:E:N108 L:L:R92 2.41 0 No No 9 6 1 0
E:E:E113 L:L:R95 3.49 2 Yes No 9 7 1 0
E:E:N110 L:L:R97 2.41 2 No Yes 9 5 1 0
E:E:E112 L:L:R97 15.12 2 No Yes 9 5 1 0
E:E:E113 L:L:R97 2.33 2 Yes Yes 9 5 1 0
E:E:I98 E:E:V123 3.07 0 No Yes 8 9 1 2
E:E:A203 E:E:I98 3.25 0 No No 9 8 2 1
E:E:V99 E:E:W120 4.9 0 No Yes 7 9 1 2
E:E:M192 E:E:Q100 2.72 2 Yes Yes 9 7 1 1
E:E:Q100 E:E:V195 4.3 2 Yes No 7 9 1 2
E:E:L106 E:E:M101 2.83 0 No Yes 9 9 2 1
E:E:M101 E:E:Y116 3.59 2 Yes Yes 9 9 1 1
E:E:M101 E:E:W120 3.49 2 Yes Yes 9 9 1 2
E:E:M101 E:E:R149 4.96 2 Yes Yes 9 9 1 2
E:E:H102 E:E:P103 9.15 2 Yes No 9 9 1 1
E:E:H102 E:E:L104 7.71 2 Yes No 9 9 1 1
E:E:P103 E:E:V124 5.3 2 No No 9 9 1 2
E:E:N108 E:E:N110 4.09 0 No No 9 9 1 1
E:E:E113 E:E:N108 3.94 2 Yes No 9 9 1 1
E:E:E112 E:E:N110 6.57 2 No No 9 9 1 1
E:E:D114 E:E:E113 2.6 2 No Yes 9 9 2 1
E:E:D114 E:E:Y116 14.94 2 No Yes 9 9 2 1
E:E:D114 E:E:R149 4.76 2 No Yes 9 9 2 2
E:E:W120 E:E:Y116 4.82 2 Yes Yes 9 9 2 1
E:E:R149 E:E:Y116 4.12 2 Yes Yes 9 9 2 1
E:E:M192 E:E:V123 3.04 2 Yes Yes 9 9 1 2
E:E:D157 E:E:K125 15.21 0 Yes Yes 9 9 2 1
E:E:E160 E:E:K125 2.7 0 No Yes 9 9 2 1
E:E:D157 E:E:M192 5.54 0 Yes Yes 9 9 2 1
E:E:M192 E:E:V195 3.04 2 Yes No 9 9 1 2
E:E:K197 E:E:N196 6.99 0 No Yes 9 9 2 1
R:R:G45 R:R:M66 1.75 0 No No 8 9 2 1
E:E:G105 L:L:L63 1.71 0 No Yes 9 9 1 0
R:R:H140 R:R:K118 1.31 0 No No 8 4 1 2
E:E:E117 E:E:Y116 1.12 0 No Yes 9 9 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
76.19Single9KB9R-spondin-29KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
71.43Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
71.43Single9KB9R-spondin-29KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
66.67Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
60.87Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
59.09Single8Y69R-spondin-28Y69-LGR4; LGR4-R-spondin-2-ZNRF3
58.33Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
52.17Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
50.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6D35Cholesterol6D35-SMO-Cholesterol
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
5.56Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
5.56Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
5.56Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.56Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
5.56Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
5.56Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
5.56Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
5.56Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
5.56Single7DTTCa7DTT-CaS; CaS-Ca-Ca
5.56Single7DTTCa7DTT-CaS; CaS-Ca-Ca
5.56Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
5.56Single7DTUTryptophan7DTU-CaS; CaS-Tryptophan
5.56Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7DTVCa; Tryptophan7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E6TCa7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.56Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.56Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
5.56Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.56Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.56Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.56Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SILCa7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7SIMCa7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
5.56Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.56Single7XW7K1-707XW7-TSH-K1-70
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
5.56Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.56Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TQBCa; LY3792688TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.56Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
5.56Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.56Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.56Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
5.56Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.56Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
5.56Single8WG9PubChem 1793948WG9-mGlu4; mGlu2-PubChem 179394
5.56Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.56Single8WGBGlutamate8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.56Single8WGCLY3792688WGC-mGlu2; mGlu4-LY379268
5.56Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
5.56Single8WGDLY341495; CPPG8WGD-mGlu4; mGlu2-LY341495; CPPG
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8WVXNorrin8WVX-LGR4-Norrin
5.56Single8WVYNorrin8WVY-LGR4-Norrin
5.56Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.56Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
5.56Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.56Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
5.56Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.56Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
5.56Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
5.56Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.56Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AVLCa9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AXFCa9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9C2FCa9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.56Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.56Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.56Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.56Single9KB7R-spondin-29KB7-LGR4-R-spondin-2
5.56Single9KGKNB189KGK-LGR4-NB18
5.56Single9KHHNorrin9KHH-LGR4-Norrin
5.56Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.56Single9MBAGlutamate9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.56Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
5.56Single9MBBLY3414959MBB-mGlu8; mGlu8-LY341495
5.56Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.56Single9MBCDCPG9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.56Single9S37NB219S37-LGR4-NB21
5.56Single9S38NB219S38-LGR4-NB21
5.56Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
5.26Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD6Ca; Ca; Tryptophan7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26Single9ASBCa9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AVGCa9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26Single9AYFCa9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.26Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.76Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.76Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.76Single7UTZTSH7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
4.76Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.76Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.55Single5L7DCholesterol5L7D-SMO-Cholesterol
4.55Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
4.55Single8I2GFSH8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.55Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.55Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.35Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.35Consensusp2y_offOrthosteric Ligandp2y1_off
4.17Single4XNWMRS25004XNW-P2Y1-MRS2500
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
4.17Single8JPSCCL78JPS-ACKR1-CCL7
4.17Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.17Single9IJRC179IJR-GPR52-C17-Arrestin2
4.17Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
4.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.00Single6LI0C176LI0-GPR52-C17
4.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
4.00Single9B9YTaranabant9B9Y-CB1-Taranabant
4.00Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00Single9MNIdC2_059MNI-CTLike-dC2_05-RAMP1
3.85Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
3.85Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
3.85Single4QINSAG1.54QIN-SMO-SAG1.5
3.85Single5U09Taranabant5U09-CB1-Taranabant
3.85Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
3.85Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
3.85Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
3.85Single7BR3Elagolix7BR3-GnRH1-Elagolix
3.85Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
3.85Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
3.85Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
3.85Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
3.85Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
3.85Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.85Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.85Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
3.85Single8YNFCXCL88YNF-ACKR1-CXCL8
3.85Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
3.85Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
3.85Single9KO6CCL199KO6-CCR7-CCL19
3.85Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.85Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.85Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.85Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
3.85Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.85Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
3.70Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
3.70Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.70Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
3.70Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
3.70Single7VV6C48/807VV6-MRGPRX2-C48/80
3.70Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.70Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.70Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9BA0MRI-18919BA0-CB1-MRI-1891
3.70Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
3.70Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
3.70Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
3.70Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.70Consensusgrh_offOrthosteric Ligandgnrh1_off
3.70Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
3.70Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.57Single4QIMANTA XV4QIM-SMO-ANTA XV
3.57Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
3.57Single5TGZAM65385TGZ-CB1-AM6538
3.57Single6D27CAY104716D27-DP2-CAY10471
3.57Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
3.57Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.57Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
3.57Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.57Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
3.57Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
3.57Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
3.57Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.57Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
3.57Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
3.57Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
3.57Single7YXAONO-54306087YXA-S1P5-ONO-5430608
3.57Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.57Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.57Single9METGp120; CD49MET-CXCR4-Gp120; CD4
3.57Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.57Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
3.57Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
3.57Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
3.45Single4JKVTaladegib4JKV-SMO-Taladegib
3.45Single5C1MBU725C1M-μ-BU72
3.45Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.45Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.45Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
3.45Single7C4SS1P7C4S-S1P3-S1P
3.45Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
3.45Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
3.45Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
3.45Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
3.45Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
3.45Single9B9ZMRI-18679B9Z-CB1-MRI-1867
3.45Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
3.45Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
3.45Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.45Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.45Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
3.45Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
3.33Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
3.33Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
3.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
3.33Single5V56TC1145V56-SMO-TC114
3.33Single5V57TC1145V57-SMO-TC114
3.33Single6OS1TRV0266OS1-AT1-TRV026
3.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
3.33Single7F1TCCL37F1T-CCR5-CCL3
3.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
3.33Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.33Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
3.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.33Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
3.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
3.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
3.33Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
3.33Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
3.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
3.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
3.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
3.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
3.33Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
3.33Single9L16CCL219L16-CCR7-CCL21
3.33Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
3.33Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
3.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
3.33Consensuslpa_onOrthosteric Ligandlpa1_on
3.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
3.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Consensusneurotensin_onOrthosteric Ligandnts1_on
3.33Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.33Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
3.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.33Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
3.23Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
3.23Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
3.23Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
3.23Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
3.23Single6OS2TRV0266OS2-AT1-TRV026
3.23Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
3.23Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.23Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
3.23Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
3.23Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
3.23Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
3.23Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
3.23Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.23Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.23Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
3.23Single8XQJJN2418XQJ-Apelin; Apelin-JN241
3.23Single8XWACXCL18XWA-CXCR2-CXCL1
3.23Single8XWMCXCL68XWM-CXCR2-CXCL6
3.23Single8XWSCXCL58XWS-CXCR2-CXCL5
3.23Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.23Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
3.23Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
3.23Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
3.23Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
3.23Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.23Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
3.23Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
3.23Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
3.23Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
3.23Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
3.23Consensuslpa_offOrthosteric Ligandlpa1_off
3.23Consensuslpl_offOrthosteric Ligands1p_off lpa_off
3.23Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.23Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.23Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
3.23Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
3.23Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.23Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.23Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
3.12Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
3.12Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.12Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
3.12Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
3.12Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.12Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
3.12Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
3.12Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
3.12Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.12Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.12Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.12Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
3.12Single8E0GBU728E0G-μ-BU72
3.12Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
3.12Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.12Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
3.12Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.12Single8XVUCXCL28XVU-CXCR2-CXCL2
3.12Single8XWFCXCL38XWF-CXCR2-CXCL3
3.12Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.12Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.12Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.12Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.12Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.12Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
3.12Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
3.12Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
3.12Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
3.12Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
3.12Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single5VBLAMG3054 5VBL-Apelin-AMG3054
3.03Single6KNMJN241-96KNM-Apelin-JN241-9
3.03Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.03Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.03Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
3.03Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
3.03Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
3.03Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
3.03Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.03Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
3.03Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.03Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
3.03Single8XQJJN2418XQJ-Apelin; Apelin-JN241
3.03Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.03Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
3.03Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
3.03Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
3.03Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.03Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.03Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
3.03Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
2.94Single4XT1CX3CL14XT1-US28-CX3CL1
2.94Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
2.94Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
2.94Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
2.94Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
2.94Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
2.94Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
2.94Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
2.94Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
2.94Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.94Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
2.94Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
2.94Single8XWNCXCL88XWN-CXCR2-CXCL8
2.94Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.94Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
2.94Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
2.94Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
2.94Single9MEJGp1209MEJ-CXCR4-Gp120
2.94Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
2.94Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
2.94Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.94Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
2.94Consensuslpl_onOrthosteric Ligands1p_on lpa_on
2.94Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
2.94Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.94Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
2.86Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
2.86Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
2.86Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
2.86Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
2.86Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
2.86Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
2.86Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
2.86Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
2.86Single7SK5CXCL127SK5-ACKR3-CXCL12
2.86Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
2.86Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.86Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
2.86Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.86Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
2.86Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
2.86Single9ME1CXCL129ME1-CXCR4-CXCL12
2.86Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
2.86Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
2.86Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
2.86Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
2.86Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
2.78Single3OE0CVX153OE0-CXCR4-CVX15
2.78Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
2.78Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
2.78Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
2.78Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
2.78Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.78Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
2.78Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
2.78Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
2.78Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
2.78Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
2.78Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.78Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
2.78Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.78Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
2.78Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
2.78Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
2.78Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
2.78Single9MEUCXCL129MEU-CXCR4-CXCL12
2.78Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78Consensusangiotensin_onOrthosteric Ligandat1_on
2.78Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.78Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.78Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
2.78Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
2.78Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
2.78Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
2.78Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.78Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.78Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.70Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
2.70Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
2.70Single6METGp160; CD46MET-CCR5-Gp160; CD4
2.70Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
2.70Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
2.70Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
2.70Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
2.70Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
2.70Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.70Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
2.70Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
2.70Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.70Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
2.70Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.70Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
2.70Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.70Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
2.70Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.70Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.70Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.70Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
2.70Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
2.70Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
2.70Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
2.70Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
2.70Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
2.70Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
2.70Consensusvasop-oxy_onOrthosteric Ligandv2_on
2.70Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
2.63Single5YQZNNC17025YQZ-Glucagon-NNC1702
2.63Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
2.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
2.63Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
2.63Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
2.63Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
2.63Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
2.63Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.63Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
2.63Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
2.63Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.63Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.63Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
2.63Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
2.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
2.63Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
2.63Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
2.63Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
2.63Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.63Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.63Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.63Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.63Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
2.63Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
2.63Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
2.63Consensuscalcitonin_onOrthosteric Ligandctlike_on
2.63Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
2.63Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
2.63Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
2.63Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
2.63Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.63Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
2.63Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
2.63Consensuspac_onOrthosteric Ligandpac1_on
2.63Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.63Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
2.56Single4XT3CX3CL14XT3-US28-CX3CL1
2.56Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
2.56Single6FJ3PTH6FJ3-PTH1-PTH
2.56Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
2.56Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
2.56Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.56Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
2.56Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.56Single7SK3CXCL127SK3-ACKR3-CXCL12
2.56Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
2.56Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
2.56Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
2.56Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.56Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
2.56Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
2.56Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.56Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
2.56Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.56Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
2.56Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
2.56Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
2.56Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
2.56Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
2.56Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.56Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
2.56Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.56Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.56Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
2.56Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
2.56Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
2.56Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
2.56Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.56Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
2.56Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
2.56Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
2.56Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
2.56Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
2.50Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.50Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
2.50Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.50Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
2.50Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
2.50Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
2.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
2.50Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
2.50Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.50Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
2.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
2.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
2.50Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.50Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
2.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.50Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
2.50Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.50Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
2.50Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
2.50Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
2.50Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
2.50Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.50Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
2.50Consensusglp_onOrthosteric Ligandglp1_on glp2_on
2.50Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
2.50Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
2.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.50Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.44Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
2.44Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.44Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
2.44Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
2.44Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.44Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
2.44Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
2.44Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.44Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.44Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.44Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
2.44Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.44Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.44Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
2.44Single8IY6Endothelin-18IY6-ETB-Endothelin-1
2.44Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.44Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
2.44Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
2.44Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
2.44Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.44Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.44Consensusbradykinin_onOrthosteric Ligandbk2_on
2.44Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
2.44Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.44Consensusendothelin_onOrthosteric Ligandetb_on eta_on
2.44Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
2.44Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
2.44Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.44Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
2.44Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
2.44Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.44Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
2.38Single5GLHEndothelin-15GLH-ETB-Endothelin-1
2.38Single6IGKEndothelin-36IGK-ETB-Endothelin-3
2.38Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.38Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
2.38Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.38Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
2.38Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
2.38Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.38Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.38Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
2.38Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
2.33Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
2.33Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
2.33Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.33Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.33Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.33Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
2.33Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.33Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
2.33Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
2.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.27Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
2.27Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
2.27Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
2.27Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
2.27Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.27Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.27Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.27Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
2.27Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.27Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
2.22Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.22Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
2.22Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
2.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
2.22Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.22Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.22Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.22Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
2.22Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
2.22Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.17Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.17Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.17Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.17Consensuspth_onOrthosteric Ligandpth1_on pth2_on
2.13Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.13Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.13Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.08Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.08Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.08Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
2.04Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.00Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
1.92Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
1.89Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 9KB8
Class A
SubFamily Orphan
Type Orphan
SubType LGR4
Species Homo sapiens
Ligand R-spondin-2
Other Ligand(s) -
Protein Partners ZNRF3; ZNRF3
PDB Resolution 3.25
Date 2025-10-15
D.O.I. doi.org/10.1038/s41467-025-64129-z
Net Summary
Imin 1.82
Number of Linked Nodes 1150
Number of Links 1514
Number of Hubs 282
Number of Links mediated by Hubs 965
Number of Communities 43
Number of Nodes involved in Communities 428
Number of Links involved in Communities 630
Path Summary
Number Of Nodes in MetaPath 278
Number Of Links MetaPath 277
Number of Shortest Paths 89311186
Length Of Smallest Path 3
Average Path Length 83.4188
Length of Longest Path 73
Minimum Path Strength 1.275
Average Path Strength 8.00595
Maximum Path Strength 25.725
Minimum Path Correlation 0.73
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.81818
Average % Of Corr. Nodes 88.7252
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 128
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • regulation of biological process   • regulation of animal organ morphogenesis   • regulation of developmental process   • regulation of odontogenesis of dentin-containing tooth   • negative regulation of developmental process   • regulation of odontogenesis   • odontogenesis of dentin-containing tooth   • odontogenesis   • animal organ development   • biological regulation   • negative regulation of biological process   • negative regulation of odontogenesis   • anatomical structure morphogenesis   • negative regulation of odontogenesis of dentin-containing tooth   • anatomical structure development   • animal organ morphogenesis   • negative regulation of animal organ morphogenesis   • regulation of multicellular organismal process   • negative regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • cellular developmental process   • ossification   • cell differentiation   • cellular process   • osteoblast differentiation   • lung growth   • developmental growth   • tube development   • growth   • respiratory tube development   • organ growth   • multicellular organism development   • lung development   • respiratory system development   • system development   • trachea cartilage morphogenesis   • connective tissue development   • trachea cartilage development   • trachea morphogenesis   • tissue development   • tissue morphogenesis   • skeletal system development   • trachea development   • cartilage morphogenesis   • cartilage development   • limb development   • appendage development   • embryonic forelimb morphogenesis   • embryonic limb morphogenesis   • embryonic morphogenesis   • embryonic appendage morphogenesis   • embryo development   • forelimb morphogenesis   • appendage morphogenesis   • limb morphogenesis   • bone mineralization   • biomineral tissue development   • cellular response to stimulus   • regulation of cellular process   • cell surface receptor signaling pathway   • response to stimulus   • signaling   • canonical Wnt signaling pathway   • cell communication   • signal transduction   • Wnt signaling pathway   • branching morphogenesis of an epithelial tube   • tube morphogenesis   • lung morphogenesis   • epithelial tube morphogenesis   • epithelium development   • morphogenesis of an epithelium   • morphogenesis of a branching structure   • epithelial tube branching involved in lung morphogenesis   • morphogenesis of a branching epithelium   • embryonic hindlimb morphogenesis   • hindlimb morphogenesis   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of Wnt signaling pathway   • positive regulation of cellular process   • regulation of signaling   • regulation of Wnt signaling pathway   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • regulation of canonical Wnt signaling pathway   • positive regulation of canonical Wnt signaling pathway   • dopaminergic neuron differentiation   • nervous system development   • generation of neurons   • neurogenesis   • neuron differentiation   • cell surface   • cellular anatomical structure   • extracellular region   • extracellular space   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • protein-hormone receptor activity   • tissue remodeling   • bone remodeling   • cell population proliferation   • renal system development   • epithelial cell proliferation involved in renal tubule morphogenesis   • renal tubule development   • epithelial cell proliferation   • renal tubule morphogenesis   • positive regulation of response to biotic stimulus   • pattern recognition receptor signaling pathway   • toll-like receptor signaling pathway   • response to biotic stimulus   • immune response-activating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • immune response   • response to other organism   • regulation of innate immune response   • response to external stimulus   • defense response to other organism   • regulation of pattern recognition receptor signaling pathway   • positive regulation of defense response   • activation of innate immune response   • regulation of immune response   • regulation of toll-like receptor signaling pathway   • activation of immune response   • regulation of defense response   • regulation of response to biotic stimulus   • biological process involved in interspecies interaction between organisms   • regulation of response to external stimulus   • negative regulation of signaling   • negative regulation of cell communication   • positive regulation of response to external stimulus   • immune response-regulating signaling pathway   • regulation of response to stress   • response to stress   • innate immune response   • negative regulation of cellular process   • response to external biotic stimulus   • positive regulation of innate immune response   • defense response   • negative regulation of response to stimulus   • defense response to symbiont   • negative regulation of signal transduction   • negative regulation of toll-like receptor signaling pathway   • negative regulation of immune system process   • immune system process   • spermatogenesis   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • developmental process involved in reproduction   • male gamete generation   • gamete generation   • mesonephric epithelium development   • kidney epithelium development   • nephron tubule morphogenesis   • regulation of kidney development   • regulation of branching involved in ureteric bud morphogenesis   • positive regulation of developmental process   • nephron development   • regulation of morphogenesis of a branching structure   • positive regulation of multicellular organismal process   • mesonephric tubule development   • nephron morphogenesis   • nephron epithelium morphogenesis   • nephron tubule development   • ureteric bud morphogenesis   • positive regulation of morphogenesis of an epithelium   • branching involved in ureteric bud morphogenesis   • regulation of morphogenesis of an epithelium   • nephron epithelium development   • ureteric bud development   • mesonephros development   • kidney morphogenesis   • positive regulation of branching involved in ureteric bud morphogenesis   • mesonephric tubule morphogenesis   • kidney development   • digestive system development   • digestive tract development   • epidermis development   • molting cycle process   • hair cycle   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • hair cycle process   • genitalia development   • reproductive system development   • sex differentiation   • male sex differentiation   • male genitalia development   • reproductive structure development   • multicellular organismal-level homeostasis   • homeostatic process   • homeostasis of number of cells   • intestinal stem cell homeostasis   • regulation of biosynthetic process   • rhythmic process   • circadian regulation of gene expression   • circadian rhythm   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • cytokine production   • regulation of cytokine production   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • metanephric tubule morphogenesis   • metanephric epithelium development   • metanephros development   • metanephros morphogenesis   • metanephric nephron tubule morphogenesis   • metanephric nephron development   • metanephric nephron epithelium development   • metanephric nephron tubule development   • metanephric nephron morphogenesis   • metanephric tubule development   • negative regulation of cold-induced thermogenesis   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • metanephric glomerulus development   • glomerulus development   • cell periphery   • plasma membrane   • membrane   • aminoacyltransferase activity   • ubiquitin-like protein transferase activity   • catalytic activity, acting on a protein   • acyltransferase activity   • transferase activity   • catalytic activity   • ubiquitin-protein transferase activity   • cation binding   • transition metal ion binding   • zinc ion binding   • ion binding   • binding   • metal ion binding   • small molecule binding   • ubiquitin-like protein ligase activity   • ubiquitin protein ligase activity   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • frizzled binding   • catabolic process   • primary metabolic process   • protein catabolic process   • macromolecule catabolic process   • modification-dependent macromolecule catabolic process   • modification-dependent protein catabolic process   • ubiquitin-dependent protein catabolic process   • protein metabolic process   • stem cell proliferation   • regulation of Wnt signaling pathway, planar cell polarity pathway   • Wnt signaling pathway, planar cell polarity pathway   • regulation of non-canonical Wnt signaling pathway   • non-canonical Wnt signaling pathway   • receptor catabolic process   • negative regulation of Wnt signaling pathway   • receptor metabolic process   • Wnt receptor catabolic process   • negative regulation of canonical Wnt signaling pathway   • protein ubiquitination   • macromolecule modification   • post-translational protein modification   • protein modification process   • protein modification by small protein conjugation   • protein modification by small protein conjugation or removal   • negative regulation of non-canonical Wnt signaling pathway
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylchitosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0



This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KB6AOrphanOrphanLGR4Homo sapiens---3.532025-10-15doi.org/10.1038/s41467-025-64129-z
9KB7AOrphanOrphanLGR4Homo sapiensR-spondin-2--3.972025-10-15doi.org/10.1038/s41467-025-64129-z
9KB8AOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.252025-10-15doi.org/10.1038/s41467-025-64129-z
9KB9AOrphanOrphanLGR4; LGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.592025-10-15doi.org/10.1038/s41467-025-64129-z
8WVUAOrphanOrphanLGR4Homo sapiensR-spondin-1-RNF433.612024-10-30To be published
8WVVAOrphanOrphanLGR4Homo sapiens---3.352024-10-30To be published
8WVWAOrphanOrphanLGR4Homo sapiens---3.532024-10-30To be published
8WVXAOrphanOrphanLGR4Homo sapiensNorrin--3.322024-10-30To be published
8WVYAOrphanOrphanLGR4Homo sapiensNorrin--3.292024-10-30To be published
8XFPAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.212024-12-04doi.org/10.1038/s41467-024-55431-3
8XFSAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF3; ZNRF33.22024-12-04doi.org/10.1038/s41467-024-55431-3
8XFTAOrphanOrphanLGR4Homo sapiensR-spondin-2-ZNRF33.242024-12-04doi.org/10.1038/s41467-024-55431-3
8Y69AOrphanOrphanLGR4; LGR4Homo sapiensR-spondin-2-ZNRF33.382024-12-04doi.org/10.1038/s41467-024-55431-3
8XT9AOrphanOrphanLGR4Homo sapiens---3.12025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XUMAOrphanOrphanLGR4Homo sapiensR-spondin-2--2.92025-01-15doi.org/10.1016/j.molcel.2025.01.024
9KGKAOrphanOrphanLGR4Homo sapiensNB18--2.632025-07-16To be published
9KHHAOrphanOrphanLGR4Homo sapiensNorrin--3.652025-07-16To be published
9S37AOrphanOrphanLGR4Homo sapiensNB21--3.942025-07-30To be published
9S38AOrphanOrphanLGR4Homo sapiensNB21--3.942025-09-03To be published




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