Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P19 4.6175404
2R:R:K22 6.9413
3R:R:Y37 7.495618
4R:R:Y58 7.38405
5R:R:Y68 8.59407
6R:R:W86 10.474517
7R:R:Y89 6.425414
8R:R:W94 9.20833619
9R:R:N98 7.8525403
10R:R:Y108 9.5675417
11R:R:F113 5.60167607
12R:R:I116 8.1325427
13R:R:F117 3.72405
14R:R:F118 8.8475447
15R:R:I120 4.2625427
16R:R:Y127 7.855108
17R:R:R140 7.245486
18R:R:W153 8.1175449
19R:R:F166 8.8225405
20R:R:E172 13.065412
21R:R:F182 7.0125405
22R:R:W190 10.3145113
23R:R:Q194 7.3425495
24R:R:P206 4.588529
25R:R:Y214 5.595409
26R:R:I217 3.955408
27R:R:M241 5.2225428
28R:R:Y244 10.2275429
29R:R:F245 6.134525
30R:R:W248 9.77529
31R:R:Y251 7.5475407
32R:R:N267 6.19254123
33R:R:Q280 6.998513
34R:R:H289 6.258529
35R:R:Y297 4.935479
36R:R:F304 4.602578
37L:L:?0 6.07530
38L:L:P2 6.205430
39L:L:M5 5.582530
40L:L:L7 6.204510
41L:L:Q8 7.39410
42L:L:L19 5.5925460
43L:L:F28 11.5275410
44L:L:V39 4.648550
45L:L:F41 6.7225450
46L:L:P53 6.3375450
47L:L:W57 13.055400
48L:L:V58 6.0975450
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:I24 L:L:L19 21.46435.71NoYes000
2L:L:F41 L:L:I24 23.564112.56YesNo000
3L:L:F41 L:L:V39 30.82585.24YesYes500
4L:L:P53 L:L:V39 57.03293.53YesYes500
5L:L:P53 R:R:Y184 64.375811.13YesNo001
6R:R:S185 R:R:Y184 73.6096.36NoNo031
7R:R:Q186 R:R:S185 75.45655.78NoNo033
8R:R:Q186 R:R:W190 77.29554.38NoYes033
9R:R:F166 R:R:W190 84.565715.03YesYes053
10R:R:F166 R:R:F182 42.740510.72YesYes055
11R:R:F182 R:R:S180 45.73416.61YesNo054
12L:L:M5 R:R:S180 15.13494.6YesNo304
13L:L:M5 R:R:S179 20.51926.13YesNo003
14L:L:F28 L:L:Q48 23.96617.03YesNo100
15L:L:Q8 R:R:S179 12.42368.66YesNo003
16L:L:Q8 R:R:E172 14.66455.1YesYes102
17L:L:F28 R:R:E172 24.231317.49YesYes102
18L:L:M5 L:L:S31 18.36386.13YesNo000
19L:L:Q8 L:L:S31 15.211911.55YesNo000
20L:L:Q48 R:R:P19 20.80579.47NoYes004
21L:L:?0 R:R:S180 31.54434.79YesNo304
22L:L:?0 R:R:L255 58.02084.42YesNo306
23R:R:L255 R:R:Y251 64.042311.72NoYes067
24R:R:E283 R:R:Y251 64.61536.73NoYes067
25R:R:E283 R:R:Q280 63.71311.47NoYes063
26L:L:L7 R:R:Q280 23.59416.65YesYes103
27L:L:L7 R:R:K22 18.08589.87YesYes103
28R:R:K22 R:R:N273 12.20972.8YesNo031
29R:R:C20 R:R:N273 10.19544.72NoNo091
30R:R:F166 R:R:Q194 57.49057.03YesYes055
31R:R:N163 R:R:Q194 60.50129.24NoYes945
32R:R:F109 R:R:N163 62.605319.33NoNo054
33R:R:F109 R:R:Y108 63.60188.25NoYes057
34L:L:P3 R:R:Y108 23.286113.91NoYes107
35L:L:P3 R:R:E283 37.60854.72NoNo006
36R:R:F79 R:R:Y108 22.041710.32NoYes077
37R:R:F79 R:R:M287 11.46994.98NoNo078
38R:R:M287 R:R:Y37 19.261914.37NoYes088
39R:R:W86 R:R:Y108 31.91215.79YesYes177
40R:R:M287 R:R:W86 13.2964.65NoYes087
41R:R:Q280 R:R:T284 13.12925.67YesNo136
42R:R:C290 R:R:F79 15.50275.59NoNo087
43R:R:C290 R:R:L80 13.31314.76NoNo086
44R:R:G44 R:R:L80 11.11493.42NoNo086
45R:R:W248 R:R:Y251 1006.75YesYes097
46R:R:H289 R:R:W248 25.44166.35YesYes299
47R:R:H289 R:R:N293 19.84785.1YesNo099
48R:R:D76 R:R:N293 16.31536.73NoNo099
49R:R:D76 R:R:N48 14.536212.12NoNo099
50R:R:F109 R:R:F113 73.86145.36NoYes057
51R:R:F112 R:R:F113 67.63469.65NoYes077
52R:R:F112 R:R:W248 68.353110.02NoYes079
53R:R:W248 R:R:Y244 97.930114.47YesYes299
54R:R:I116 R:R:Y244 49.895216.92YesYes279
55R:R:I116 R:R:I119 38.16024.42YesNo078
56R:R:I119 R:R:I240 39.44754.42NoNo088
57R:R:I240 R:R:Y297 37.7714.84NoYes089
58R:R:F304 R:R:Y297 29.50435.16YesYes789
59R:R:F113 R:R:F117 81.20864.29YesYes075
60R:R:F117 R:R:T152 76.16223.89YesNo056
61R:R:F118 R:R:T152 35.65416.49YesNo076
62R:R:F118 R:R:W153 30.95418.02YesYes479
63R:R:F78 R:R:W153 23.22639.02NoYes079
64R:R:F78 R:R:I74 21.62253.77NoNo076
65R:R:I74 R:R:L70 20.01032.85NoNo066
66R:R:I52 R:R:L70 11.82064.28NoNo076
67R:R:F304 R:R:I54 22.89276.28YesNo087
68R:R:I54 R:R:Y307 21.16074.84NoNo075
69R:R:Y307 R:R:Y58 14.22832.98NoYes055
70R:R:L121 R:R:T152 44.47684.42NoNo066
71R:R:L121 R:R:Y68 42.997110.55NoYes067
72R:R:M64 R:R:Y68 32.399611.97NoYes067
73R:R:M64 R:R:R140 27.58416.2NoYes866
74R:R:W86 R:R:W94 39.91366.56YesYes179
75R:R:F96 R:R:W94 26.309714.03NoYes079
76R:R:F96 R:R:H88 18.80439.05NoNo075
77R:R:D95 R:R:H88 15.74228.82NoNo035
78L:L:Q8 R:R:T177 12.15414.25YesNo102
79R:R:T177 R:R:Y89 26.08314.99NoYes124
80R:R:W94 R:R:Y89 18.57339.65YesYes194
81L:L:L4 R:R:Q280 13.3736.65NoYes103
82L:L:L4 R:R:Y89 17.29467.03NoYes104
83R:R:D95 R:R:Q93 14.19837.83NoNo033
84R:R:Q93 R:R:Y176 12.645912.4NoNo034
85R:R:C101 R:R:W94 12.68875.22NoYes199
86R:R:C101 R:R:S169 13.79633.44NoNo094
87R:R:N98 R:R:S169 11.85057.45YesNo034
88R:R:F245 R:R:Y244 51.77695.16YesYes259
89R:R:A129 R:R:R140 24.57346.91NoYes086
90R:R:A129 R:R:R126 22.98254.15NoNo089
91R:R:D233 R:R:R126 21.374515.48NoNo089
92R:R:F245 R:R:M210 41.9454.98YesNo258
93R:R:M210 R:R:Y214 43.41623.59NoYes089
94R:R:I217 R:R:Y214 33.55434.84YesYes089
95R:R:I217 R:R:Y127 14.5024.84YesYes088
96R:R:K171 R:R:Y176 11.08517.91NoNo024
97R:R:F112 R:R:I198 10.49053.77NoNo075
98R:R:D233 R:R:K229 19.843516.59NoNo086
99R:R:K229 R:R:R232 18.226917.33NoNo067
100R:R:E302 R:R:R232 14.959611.63NoNo057
101R:R:E302 R:R:G301 11.72653.27NoNo058
102L:L:A6 R:R:Q280 33.00264.55NoYes003
103L:L:A6 R:R:M279 31.12956.44NoNo005
104R:R:M279 R:R:N258 29.24775.61NoNo054
105R:R:L275 R:R:N258 17.77795.49NoNo054
106R:R:L266 R:R:L275 15.83635.54NoNo045
107L:L:V58 L:L:W57 10.678712.26YesYes000
108R:R:E172 R:R:T177 13.390116.93YesNo122
109L:L:?0 L:L:M5 25.40736.02YesYes300
110L:L:P3 R:R:W86 14.472125.67NoYes107
111L:L:V39 L:L:V58 14.49344.81YesYes500
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:I15 R:R:S17 6.19 6 No No 0 4 0 1
L:L:V49 R:R:S17 4.85 6 No No 0 4 0 1
L:L:Q48 R:R:P19 9.47 1 No Yes 0 4 0 1
L:L:C50 R:R:P19 5.65 0 No Yes 0 4 0 1
R:R:C20 R:R:C269 7.28 0 No No 9 6 1 2
R:R:C20 R:R:N273 4.72 0 No No 9 1 1 2
L:L:F12 R:R:C20 4.19 0 No No 0 9 0 1
R:R:K22 R:R:V25 10.62 1 Yes No 3 1 1 2
R:R:K22 R:R:K26 4.31 1 Yes No 3 1 1 1
L:L:L7 R:R:K22 9.87 1 Yes Yes 0 3 0 1
R:R:H175 R:R:K26 5.24 0 No No 1 1 2 1
L:L:L7 R:R:K26 4.23 1 Yes No 0 1 0 1
L:L:L7 R:R:A29 4.73 1 Yes No 0 5 0 1
R:R:F79 R:R:Y108 10.32 0 No Yes 7 7 2 1
R:R:F79 R:R:M287 4.98 0 No No 7 8 2 2
R:R:T82 R:R:W86 9.7 0 No Yes 7 7 2 1
R:R:W86 R:R:W94 6.56 1 Yes Yes 7 9 1 2
R:R:W86 R:R:Y108 5.79 1 Yes Yes 7 7 1 1
R:R:M287 R:R:W86 4.65 0 No Yes 8 7 2 1
L:L:P3 R:R:W86 25.67 1 No Yes 0 7 0 1
R:R:W94 R:R:Y89 9.65 1 Yes Yes 9 4 2 1
R:R:T177 R:R:Y89 4.99 1 No Yes 2 4 1 1
R:R:C178 R:R:Y89 4.03 1 No Yes 9 4 2 1
L:L:L4 R:R:Y89 7.03 1 No Yes 0 4 0 1
R:R:C178 R:R:W94 16.98 1 No Yes 9 9 2 2
R:R:T105 R:R:T167 14.13 3 No No 5 5 1 1
L:L:P2 R:R:T105 8.74 3 Yes No 0 5 0 1
R:R:F109 R:R:Y108 8.25 0 No Yes 5 7 2 1
L:L:P3 R:R:Y108 13.91 1 No Yes 0 7 0 1
R:R:F166 R:R:F182 10.72 0 Yes Yes 5 5 2 1
L:L:P2 R:R:T167 6.99 3 Yes No 0 5 0 1
R:R:E172 R:R:Q170 12.74 1 Yes No 2 1 1 1
R:R:H181 R:R:Q170 11.13 0 No No 4 1 2 1
L:L:F28 R:R:Q170 5.86 1 Yes No 0 1 0 1
R:R:K171 R:R:Y176 17.91 0 No No 2 4 1 2
L:L:E26 R:R:K171 10.8 0 No No 0 2 0 1
R:R:E172 R:R:T177 16.93 1 Yes No 2 2 1 1
L:L:Q8 R:R:E172 5.1 1 Yes Yes 0 2 0 1
L:L:F28 R:R:E172 17.49 1 Yes Yes 0 2 0 1
L:L:Q8 R:R:T177 4.25 1 Yes No 0 2 0 1
R:R:H181 R:R:S179 5.58 0 No No 4 3 2 1
L:L:M5 R:R:S179 6.13 3 Yes No 0 3 0 1
L:L:Q8 R:R:S179 8.66 1 Yes No 0 3 0 1
R:R:F182 R:R:S180 6.61 0 Yes No 5 4 1 1
L:L:?0 R:R:S180 4.79 3 Yes No 0 4 0 1
L:L:M5 R:R:S180 4.6 3 Yes No 0 4 0 1
R:R:F182 R:R:K191 6.2 0 Yes No 5 4 1 2
L:L:G32 R:R:F182 4.52 0 No Yes 0 5 0 1
R:R:S185 R:R:Y184 6.36 0 No No 3 1 2 1
L:L:P53 R:R:Y184 11.13 5 Yes No 0 1 0 1
L:L:R59 R:R:Y184 5.14 0 No No 0 1 0 1
R:R:K191 R:R:Y187 8.36 0 No No 4 3 2 1
L:L:G32 R:R:Y187 4.35 0 No No 0 3 0 1
L:L:P37 R:R:Y187 18.08 0 No No 0 3 0 1
R:R:L255 R:R:T195 4.42 3 No No 6 5 1 1
R:R:T195 R:R:T259 14.13 3 No No 5 5 1 2
L:L:?0 R:R:T195 7.84 3 Yes No 0 5 0 1
R:R:L255 R:R:Y251 11.72 3 No Yes 6 7 1 2
R:R:E283 R:R:Y251 6.73 0 No Yes 6 7 1 2
L:L:?0 R:R:L255 4.42 3 Yes No 0 6 0 1
R:R:N258 R:R:Q261 6.6 0 No No 4 4 2 1
R:R:M279 R:R:N258 5.61 0 No No 5 4 1 2
R:R:N267 R:R:Q261 3.96 12 Yes No 3 4 1 1
L:L:S35 R:R:Q261 10.11 12 No No 0 4 0 1
R:R:E262 R:R:N267 13.15 0 No Yes 3 3 2 1
L:L:S35 R:R:N267 5.96 12 No Yes 0 3 0 1
L:L:F12 R:R:S272 5.28 0 No No 0 3 0 1
L:L:K33 R:R:D276 9.68 0 No No 0 4 0 1
L:L:A6 R:R:M279 6.44 0 No No 0 5 0 1
R:R:E283 R:R:Q280 11.47 0 No Yes 6 3 1 1
R:R:Q280 R:R:T284 5.67 1 Yes No 3 6 1 2
L:L:L4 R:R:Q280 6.65 1 No Yes 0 3 0 1
L:L:A6 R:R:Q280 4.55 0 No Yes 0 3 0 1
L:L:L7 R:R:Q280 6.65 1 Yes Yes 0 3 0 1
L:L:P3 R:R:E283 4.72 1 No No 0 6 0 1
R:R:K22 R:R:N273 2.8 1 Yes No 3 1 1 2
L:L:V42 R:R:G173 1.84 0 No No 0 1 0 1
L:L:S9 R:R:P19 1.78 0 No Yes 0 4 0 1
R:R:G265 R:R:N267 1.7 0 No Yes 4 3 2 1
R:R:S17 R:R:T16 1.6 6 No No 4 2 1 2
R:R:E18 R:R:P19 1.57 0 No Yes 3 4 2 1
L:L:S9 R:R:Q21 1.44 0 No No 0 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
76.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
70.83Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
64.29Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
64.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
64.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
64.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
61.54Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
60.71Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
58.33Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
57.14Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
53.85Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
53.85Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
52.17Single7F1TMIP-1a7F1T-CCR5-MIP-1a
52.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
52.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
51.72Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
50.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
50.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
50.00Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
50.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
50.00Consensusdp_offOrthosteric Liganddp2_off
50.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
50.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
48.48Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
48.39Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
48.39Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
48.39Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
48.39Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
48.28Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
48.28Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
48.15Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
46.88Single5GLHEndothelin-15GLH-ETB-Endothelin-1
46.88Single6IGKEndothelin-36IGK-ETB-Endothelin-3
46.67Single4XT3Fractalkine4XT3-US28-Fractalkine
46.67Single7SK3CXCL127SK3-ACKR3-CXCL12
46.43Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
46.43Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
46.43Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
46.15Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
44.83Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
44.83Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
44.83Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
44.83Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Single4XT1Fractalkine4XT1-US28-Fractalkine
44.44Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
44.44Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
44.00Single6OS2TRV0266OS2-AT1-TRV026
44.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
43.48Single6D27CAY104716D27-DP2-CAY10471
43.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
43.33Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.33Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
42.86Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
42.42Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
42.31Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
42.31Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
42.31Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
41.67Single6D26Fevipiprant6D26-DP2-Fevipiprant
41.38Single3OE0CVX153OE0-CXCR4-CVX15
41.38Single7XNACYN1548067XNA-SST2-CYN154806
41.38Consensusangiotensin_onOrthosteric Ligandat1_on
41.38Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
41.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
40.74Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
40.74Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
40.74Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
40.74Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
40.62Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
40.62Consensusendothelin_onOrthosteric Ligandetb_on eta_on
40.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
40.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
40.00Single6OS1TRV0266OS1-AT1-TRV026
40.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
40.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
40.00Single7PX4PSB-21137PX4-A2A-PSB-2113
40.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
40.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
40.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
40.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
40.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
40.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
40.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
40.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
39.39Single6IGLIRL16206IGL-ETB-IRL1620
39.29Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
39.29Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
39.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
39.13Single7AROLUF58337ARO-A2A-LUF5833-Na
38.89Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
38.89Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
38.89Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
38.89Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
38.71Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
38.71Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
38.71Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
38.71Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
38.71Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
38.71Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
38.71Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.71Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.71Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
38.46Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
38.46Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
38.46Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
38.46Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensuschemokine_offOrthosteric Ligandcxcr_off
38.46Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
38.46Consensuscxcr_offOrthosteric Ligandcxcr4_off
38.46Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
37.93Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
37.93Single7SK5CXCL127SK5-ACKR3-CXCL12
37.93Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
37.93Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
37.93Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.93Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
37.93Consensussst_offOrthosteric Ligandsst2_off
37.50Single6LPJZM2413856LPJ-A2A-ZM241385-Na
37.50Single6LPKZM2413856LPK-A2A-ZM241385-Na
37.50Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
37.50Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
37.50Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
37.50Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
37.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
37.50Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
37.04Single4BUONeurotensin4BUO-NTS1-Neurotensin
37.04Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
37.04Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
37.04Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.04Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
37.04Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.04Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.04Consensusorexin_onOrthosteric Ligandox2_on
36.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.67Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
36.67Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
36.36Single3OE9IT1t3OE9-CXCR4-IT1t
36.36Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
36.36Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
36.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.00Single5N2SPSB365N2S-A1-PSB36
36.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
36.00Single6S0QZM2413856S0Q-A2A-ZM241385
36.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
36.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
36.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
36.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
36.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
36.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
36.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
35.71Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
35.71Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
35.48Single6JODAngiotensin II6JOD-AT2-Angiotensin II
35.48Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.48Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.48Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
35.29Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
35.29Single8IY6Endothelin-18IY6-ETB-Endothelin-1
35.29Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.78Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
34.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
34.62Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
34.62Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
34.62Single7TUYGSK682753A7TUY-GPR183-GSK682753A
34.62Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
34.62Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
34.62Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
34.62Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
34.62Consensusadenosine_offOrthosteric Liganda1_off a2_off
34.62Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
34.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
34.62Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
34.62Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Consensusrelaxin_onOrthosteric Ligandrxfp4_on
34.48Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
34.48Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
34.48Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
34.48Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.48Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
34.48Consensussst_onOrthosteric Ligandsst2_on sst4_on
34.38Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
34.38Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
33.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
33.33Single4XESNeurotensin4XES-NTS1-Neurotensin
33.33Single5IU4ZM2413855IU4-A2A-ZM241385-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5K2CZM2413855K2C-A2A-ZM241385-Na
33.33Single5NLXZM2413855NLX-A2A-ZM241385-Na
33.33Single5NM4ZM2413855NM4-A2A-ZM241385-Na
33.33Single6MH8ZM2413856MH8-A2A-ZM241385
33.33Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
33.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
33.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
33.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
33.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
33.33Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
33.33Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
33.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
33.33Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
33.33Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensushca_onOrthosteric Ligandhca2_on hca3_on
33.33Consensushcar_onOrthosteric Ligandhca_on
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
33.33Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
33.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
33.33Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
33.33Consensusnts_offOrthosteric Ligandnts1_off
32.35Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
32.26Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
32.14Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
32.14Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
32.14Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
32.14Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
32.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
32.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
32.14Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
32.14Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
32.14Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
32.00Single3EMLZM2413853EML-A2A-ZM241385
32.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
32.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
32.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
32.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
32.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
32.00Single5UENDU1725UEN-A1-DU172
32.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
32.00Single6S0LZM2413856S0L-A2A-ZM241385
32.00Single7PYRPSB-21157PYR-A2A-PSB-2115
32.00Single8CU6LJ-45178CU6-A2A-LJ-4517
32.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
32.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
32.00Consensusa2_offOrthosteric Liganda2a_off
32.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
32.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
32.00Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
31.82Single3OE6IT1t3OE6-CXCR4-IT1t
31.43Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
31.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
31.25Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
31.25Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
31.03Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
31.03Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.03Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.03Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
31.03Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
31.03Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.03Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.03Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
31.03Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.03Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.77Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.77Single5NM2ZM2413855NM2-A2A-ZM241385-Na
30.77Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.77Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
30.77Single6Z4SSR486926Z4S-NTS1-SR48692
30.77Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.77Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.77Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.77Single8GNEKW-63568GNE-A2A-KW-6356-Na
30.77Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.77Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
30.56Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.56Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
30.43Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
30.43Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
30.43Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
30.30Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
30.30Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.00Single7F8XNN90567F8X-CCKA-NN9056
30.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
30.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
30.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.63Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
29.63Single5V56TC1145V56-SMO-TC114
29.63Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
29.63Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
29.63Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
29.63Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
29.63Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
29.63Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
29.63Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
29.63Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
29.63Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.63Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
29.41Single6FJ3PTH6FJ3-PTH1-PTH
29.41Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single3ODUIT1t3ODU-CXCR4-IT1t
29.17Single3PWHZM2413853PWH-A2A-ZM241385
29.17Single5K2DZM2413855K2D-A2A-ZM241385
29.17Single6JZHZM2413856JZH-A2A-ZM241385-Na
29.17Single6PS7ZM2413856PS7-A2A-ZM241385-Na
29.17Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
29.17Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
29.17Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
29.17Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
29.03Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
29.03Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.03Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
29.03Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.03Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.57Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.57Consensusblt_offOrthosteric Ligandblt1_off
28.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
28.57Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
28.57Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
28.57Consensusnts_onOrthosteric Ligandnts1_on
28.21Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
28.21Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
28.12Single5WF5UK-4320975WF5-A2A-UK-432097
28.12Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.12Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.12Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
28.12Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
28.12Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
28.12Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Single3REYPubChem 56973REY-A2A-PubChem 5697
28.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
28.00Single5JTBZM2413855JTB-A2A-ZM241385
28.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
28.00Single5UVIZM2413855UVI-A2A-ZM241385
28.00Single6AQFZM2413856AQF-A2A-ZM241385
28.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
28.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
28.00Single6ZINSR486926ZIN-NTS1-SR48692
28.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
28.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
28.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
28.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
28.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
28.00Single8K5CAcipimox8K5C-HCA2-Acipimox
28.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
28.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
28.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
27.59Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.59Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
27.59Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.59Single7EZCUKA7EZC-A2A-UKA
27.59Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.59Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
27.59Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
27.59Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
27.59Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
27.50Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
27.27Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
26.92Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.92Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.92Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
26.92Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.92Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
26.92Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
26.92Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.92Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.92Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
26.92Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
26.92Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.92Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
26.92Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.92Single8K5DGSK2560738K5D-HCA2-GSK256073
26.92Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.92Consensusadenosine_onOrthosteric Liganda1_on a2_on
26.92Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Consensusgi_hcarOrthosteric Ligandgi_hca
26.92Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.92Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.92Consensusnucleotide_onOrthosteric Ligandadenosine_on
26.67Single5WF6UK-4320975WF6-A2A-UK-432097
26.67Single6KNMJN241-96KNM-Apelin-JN241-9
26.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
26.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
26.67Single7XN9L-054,5227XN9-SST2-L-054,522
26.67Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
26.67Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
26.67Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
26.67Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
26.67Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.67Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.47Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
26.47Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.47Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
26.47Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
26.09Single3OE8IT1t3OE8-CXCR4-IT1t
26.09Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.93Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
25.93Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
25.93Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
25.93Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
25.93Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.93Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.93Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.93Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
25.93Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.93Single8QOTNanobody E8QOT-μ-Nanobody E
25.93Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.93Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.81Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.81Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
25.81Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.81Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
25.81Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
25.71Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
25.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
25.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single5V57TC1145V57-SMO-TC114
25.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
25.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
25.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
25.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
25.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
25.00Single8E0GBU728E0G-μ-BU72
25.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
25.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
25.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
25.00Consensuschemerin_onOrthosteric Ligandcml1_on
25.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
25.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
25.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
25.00Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensuslpa_onOrthosteric Ligandlpa1_on
25.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
25.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
24.44Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.39Consensuspth_onOrthosteric Ligandpth1_on pth2_on
24.32Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
24.32Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
24.32Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Single6PT2KGCHM076PT2-δ-KGCHM07
24.24Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
24.24Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
24.24Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
24.24Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
24.24Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.24Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.24Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
24.14Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
24.14Single6MXTSalmeterol6MXT-β2-Salmeterol
24.14Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
24.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
24.14Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
24.14Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
24.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
24.14Single7YITNalfurafine7YIT-κ-Nalfurafine
24.14Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
24.14Single8JWZAB9288JWZ-A2A-AB928-Na
24.14Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
24.14Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
24.14Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
24.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
24.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
24.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
24.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
24.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
24.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
24.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
24.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
24.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
24.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
24.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
24.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
24.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
24.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
24.00Single7XRRLemborexant7XRR-OX2-Lemborexant
24.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
24.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
24.00Single8IHKAcifran8IHK-HCA3-Acifran
24.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
24.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
24.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
24.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
24.00Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
23.68Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
23.53Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
23.53Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
23.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
23.33Single6IBLArformoterol6IBL-β1-Arformoterol
23.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
23.33Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
23.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
23.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
23.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
23.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
23.33Consensusendothelin_offOrthosteric Ligandetb_off
23.33Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
23.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.26Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
23.08Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
23.08Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
23.08Single6V9SGTPL114036V9S-OX1-GTPL11403
23.08Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
23.08Single7T32ZM2413857T32-A2A-ZM241385
23.08Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.08Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
23.08Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
23.08Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.08Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
23.08Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
23.08Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.08Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.08Consensusgnrh_offOrthosteric Ligandgnrh1_off
23.08Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
23.08Consensuss1p_offOrthosteric Ligands1p1_off
22.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
22.86Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
22.86Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.58Single3NY9PubChem 9131033NY9-β2-PubChem 913103
22.58Single4UG2CGS216804UG2-A2A-CGS21680
22.58Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.58Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.58Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.58Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
22.58Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
22.58Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.58Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.58Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
22.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
22.22Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
22.22Single4YAYZD-71554YAY-AT1-ZD-7155
22.22Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.22Single5T04Neurotensin5T04-NTS1-Neurotensin
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6GPSMK08126GPS-CCR2-MK0812
22.22Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Single6TOTLemborexant6TOT-OX1-Lemborexant
22.22Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
22.22Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
22.22Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
22.22Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
22.22Single7UL4Alvimopan7UL4-μ-Alvimopan
22.22Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
22.22Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
22.22Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
22.22Consensuscck_offOrthosteric Ligandccka_off
22.22Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.22Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
22.22Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
21.95Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.88Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
21.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.88Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
21.88Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.88Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.88Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
21.88Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
21.88Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
21.88Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
21.74Single3RFMCaffeine3RFM-A2A-Caffeine
21.74Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.74Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.62Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
21.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
21.43Single5C1MBU725C1M-μ-BU72
21.43Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
21.43Single5WQCEMPA5WQC-OX2-EMPA
21.43Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.43Single6GPXMK08126GPX-CCR2-MK0812
21.43Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.43Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
21.43Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.43Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
21.43Single7SINNPS-21437SIN-CaS-NPS-2143
21.43Single7SINNPS-21437SIN-CaS-NPS-2143
21.43Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
21.43Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
21.43Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
21.43Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
21.43Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
21.43Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.43Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
21.43Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
21.43Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
21.43Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
21.21Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.21Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
21.21Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.05Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
21.05Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
21.05Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
20.83Single4XNWMRS25004XNW-P2Y1-MRS2500
20.83Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.83Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.83Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
20.69Single3P0GBI1671073P0G-β2-BI167107
20.69Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
20.69Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
20.69Single4RWADIPP-NH24RWA-δ-DIPP-NH2
20.69Single5X93K-87945X93-ETB-K-8794
20.69Single5XRAAM115425XRA-CB1-AM11542
20.69Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.69Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
20.69Single7B6WCyclazosin7B6W-α1b-Cyclazosin
20.69Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
20.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
20.69Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
20.69Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.69Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
20.69Single7W41PD1762527W41-BB2-PD176252
20.69Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.69Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
20.69Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
20.69Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
20.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
20.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
20.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.69Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.69Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
20.69Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
20.69Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.69Consensusbombesin_offOrthosteric Ligandbb2_off
20.69Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.69Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.69Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
20.69Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.69Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
20.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
20.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
20.59Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.59Single6W25SHU91196W25-MC4-SHU9119-Ca
20.59Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.51Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
20.45Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.00Single4LDEBI1671074LDE-β2-BI167107
20.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single6A93Risperidone6A93-5-HT2A-Risperidone
20.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
20.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
20.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
20.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
20.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8GH1Epinephrine8GH1-β2-Epinephrine
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
20.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
20.00Single8JJ8Formoterol8JJ8-β2-Formoterol
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
20.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
20.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
20.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
20.00Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
20.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
20.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
20.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
20.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.51Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
19.51Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
19.44Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.44Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
19.44Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
19.44Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
19.35Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
19.35Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
19.35Single6H7LDobutamine6H7L-β1-Dobutamine
19.35Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
19.35Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
19.35Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
19.35Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.35Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
19.35Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
19.35Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
19.35Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
19.35Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.35Consensussteroid_onOrthosteric Ligandbileacid_on
19.23Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
19.23Single4S0VSuvorexant4S0V-OX2-Suvorexant
19.23Single5WS3EMPA5WS3-OX2-EMPA
19.23Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
19.23Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
19.23Single6TPJSuvorexant6TPJ-OX2-Suvorexant
19.23Single7BR3Elagolix7BR3-GnRH1-Elagolix
19.23Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
19.23Single7F8ULintitript7F8U-CCKA-Lintitript
19.23Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
19.23Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
19.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
19.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
19.23Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
19.23Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
19.23Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
19.23Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
19.23Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
19.23Consensusclass-f_offOrthosteric Ligandsmo_off
19.23Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
19.23Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
19.23Consensusmglu_onOther Ligandmglu2_on mglu4_on
19.23Consensusorexin_offOrthosteric Ligandox2_off ox1_off
19.15Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
18.92Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.92Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
18.92Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
18.75Single5ZTYAM102575ZTY-CB2-AM10257
18.75Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
18.75Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
18.75Single8X5YAstemizole8X5Y-H1-Astemizole
18.75Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.75Consensusclass-d_offOrthosteric Ligandste2_off
18.75Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
18.60Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
18.52Single2YDOAdenosine2YDO-A2A-Adenosine
18.52Single4ZJCSB-6740424ZJC-OX1-SB-674042
18.52Single6DS0Ly2660976DS0-5-HT2B-Ly266097
18.52Single6IQLL7458706IQL-D4-L745870
18.52Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
18.52Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
18.52Single6TP3Nemorexant6TP3-OX1-Nemorexant
18.52Single6TPGEMPA6TPG-OX2-EMPA
18.52Single6TPKRetosiban6TPK-OT-Retosiban
18.52Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
18.52Single6ZG9GSK10347026ZG9-M1-GSK1034702
18.52Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.52Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
18.52Single7VV6C48/807VV6-MRGPRX2-C48/80
18.52Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
18.52Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.52Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
18.52Single8K2WAMG4878K2W-CXCR3-AMG487
18.52Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.52Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.52Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
18.52Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
18.52Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
18.52Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
18.52Consensusvasopressin-ot_offOrthosteric Ligandot_off
18.42Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
18.42Consensusgo_class-b1Orthosteric Ligandgo_crf
18.42Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.42Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.18Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
18.18Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
17.95Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
17.95Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.95Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.95Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.86Single2Y02Carmoterol2Y02-β1-Carmoterol
17.86Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
17.86Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
17.86Single5TGZAM65385TGZ-CB1-AM6538
17.86Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.86Single6PS1Timolol6PS1-β2-Timolol
17.86Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
17.86Single7BU7BI1671077BU7-β1-BI167107
17.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
17.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
17.86Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
17.86Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
17.86Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
17.86Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
17.86Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
17.86Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.86Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.86Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.86Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
17.86Consensushcar_offOrthosteric Ligandsuccinate_off
17.86Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
17.86Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.65Single6HLOAprepitant6HLO-NK1-Aprepitant
17.65Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
17.65Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
17.65Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
17.65Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
17.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.50Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.39Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
17.39Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
17.39Single8PWNTheophylline8PWN-A2A-Theophylline
17.24Single2Y00Dobutamine2Y00-β1-Dobutamine
17.24Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
17.24Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
17.24Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.24Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.24Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.24Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
17.24Single6E67BI1671076E67-β2-BI167107-Gs (fused)
17.24Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
17.24Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.24Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.24Single6TP6Filorexant6TP6-OX1-Filorexant
17.24Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
17.24Single7C4SS1P7C4S-S1P3-S1P
17.24Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
17.24Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
17.24Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
17.24Single7XKAEpinephrine7XKA-β2-Epinephrine
17.24Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
17.24Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
17.24Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
17.24Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
17.24Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.24Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.24Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.24Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.24Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
17.24Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
17.24Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
17.24Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.24Consensusep_offOrthosteric Ligandep4_off
17.07Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.07Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
17.07Consensusglp_onOrthosteric Ligandglp1_on glp2_on
17.02Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
16.67Single2YDVNECA2YDV-A2A-NECA
16.67Single4DJHJDTic4DJH-κ-JDTic
16.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
16.67Single4UHRCGS216804UHR-A2A-CGS21680
16.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
16.67Single5G53NECA5G53-A2A-NECA-Gs
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
16.67Single6J20Aprepitant6J20-NK1-Aprepitant
16.67Single6J21Aprepitant6J21-NK1-Aprepitant
16.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
16.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
16.67Single6WGTLSD6WGT-5-HT2A-LSD
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
16.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
16.67Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
16.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
16.67Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
16.67Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
16.67Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
16.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
16.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Consensus5ht5_offOrthosteric Ligand5ht5a_off
16.67Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
16.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
16.67Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
16.67Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
16.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
16.67Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
16.67Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.28Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
16.22Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.22Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.13Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.13Single4AMIBucindolol4AMI-β1-Bucindolol
16.13Single4N4WSANT-14N4W-SMO-SANT-1
16.13Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.13Single5X33BIIL2605X33-BLT1-BIIL260
16.13Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.13Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
16.13Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
16.13Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.13Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
16.13Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.13Single7DFPSpiperone7DFP-D2-Spiperone
16.13Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
16.13Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.13Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.13Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
16.13Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
16.13Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
16.13Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.13Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.13Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
16.13Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
16.13Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
16.13Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
16.13Consensusclass-b2_onOrthosteric Ligandadgrg_on
16.13Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.13Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
16.13Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
16.13Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.00Single3UZAGTPL92363UZA-A2A-GTPL9236
16.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
16.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
16.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.79Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
15.79Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
15.79Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
15.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
15.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
15.79Consensusclass-d_onOrthosteric Ligandste2_on
15.62Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
15.62Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
15.62Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.62Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.62Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.62Single6K1QIRL25006K1Q-ETB-IRL2500
15.62Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
15.62Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
15.62Single7UM4AS26747237UM4-5-HT5A-AS2674723
15.62Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
15.62Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
15.62Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
15.62Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
15.62Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
15.62Consensuscyslt_offOrthosteric Ligandcyslt2_off
15.62Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
15.62Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.62Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
15.62Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.62Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single4O9RCyclopamine4O9R-SMO-Cyclopamine
15.38Single5L7IVismodegib5L7I-SMO-Vismodegib
15.38Single6HLLCP999946HLL-NK1-CP99994
15.38Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
15.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.38Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
15.38Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.38Single7UL2SR486927UL2-NTS1-SR48692-Na
15.38Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.38Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
15.38Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.38Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.38Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.38Consensusclass-t_onOrthosteric Ligandtaste2_on
15.38Consensusgi_class-dOrthosteric Ligandgi_ste
15.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Consensusgs_class-tOrthosteric Ligandgs_taste
15.38Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.38Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
15.38Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
15.38Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.22Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
15.15Single5EE7MK08935EE7-Glucagon-MK0893
15.15Single6PT3DPI-2876PT3-δ-DPI-287
15.15Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.15Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
15.15Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgs_class-b2Orthosteric Ligandgs_adgr
15.00Single6LMLGlucagon6LML-Glucagon-Glucagon
15.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.00Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
15.00Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.89Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81Single4QINSAG1.54QIN-SMO-SAG1.5
14.81Single5DHHSB-6121115DHH-NOP-SB-612111
14.81Single5U09Taranabant5U09-CB1-Taranabant
14.81Single6AKXA4R6AKX-CCR5-A4R
14.81Single6B73PubChem 1319551386B73-κ-PubChem 131955138
14.81Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.81Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
14.81Single6TODEMPA6TOD-OX1-EMPA-Na
14.81Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
14.81Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
14.81Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
14.81Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
14.81Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
14.81Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
14.81Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
14.81Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
14.81Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
14.81Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
14.81Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
14.81Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.81Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.81Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
14.81Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
14.71Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
14.71Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.63Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.63Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.63Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.63Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
14.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
14.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
14.29Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
14.29Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
14.29Single6PS4ICI 118-5516PS4-β2-ICI 118-551
14.29Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
14.29Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
14.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.29Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
14.29Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
14.29Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8GGKEpinephrine8GGK-β2-Epinephrine
14.29Single8GGMEpinephrine8GGM-β2-Epinephrine
14.29Single8GGPEpinephrine8GGP-β2-Epinephrine
14.29Single8GGQEpinephrine8GGQ-β2-Epinephrine
14.29Single8GGTEpinephrine8GGT-β2-Epinephrine
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
14.29Consensusgi_class-fOrthosteric Ligandgi_frizzled
14.29Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
13.95Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
13.95Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
13.89Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.79Single2Y01Dobutamine2Y01-β1-Dobutamine
13.79Single2Y04Salbutamol2Y04-β1-Salbutamol
13.79Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.79Single3NY8ICI 118-5513NY8-β2-ICI 118-551
13.79Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
13.79Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.79Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.79Single4EJ4Naltrindole4EJ4-δ-Naltrindole
13.79Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
13.79Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
13.79Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
13.79Single6DRXLisuride6DRX-5-HT2B-Lisuride
13.79Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.79Single6IIVDaltroban6IIV-TP-Daltroban
13.79Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
13.79Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
13.79Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
13.79Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
13.79Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.79Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
13.79Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
13.79Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
13.79Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.79Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
13.79Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.79Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
13.79Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
13.79Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.79Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
13.79Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
13.79Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
13.79Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
13.79Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
13.79Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.79Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
13.79Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
13.79Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.79Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.79Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
13.79Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
13.79Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
13.79Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8GGJEpinephrine8GGJ-β2-Epinephrine
13.79Single8GGNEpinephrine8GGN-β2-Epinephrine
13.79Single8GGOEpinephrine8GGO-β2-Epinephrine
13.79Single8GGUEpinephrine8GGU-β2-Epinephrine
13.79Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
13.79Single8JJOAlprenolol8JJO-β2-Alprenolol
13.79Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.79Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
13.79Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
13.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.79Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
13.79Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
13.79Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
13.79Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
13.79Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
13.79Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
13.79Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
13.64Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.51Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
13.51Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.51Consensusclass-d_onOrthosteric Ligandste2_on
13.51Consensusgi_class-dOrthosteric Ligandgi_ste
13.51Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
13.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.33Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
13.33Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
13.33Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
13.33Single5TVNLSD5TVN-5-HT2B-LSD
13.33Single5WIUNemonapride5WIU-D4-Nemonapride
13.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.33Single5XPRBosentan5XPR-ETB-Bosentan
13.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.33Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
13.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
13.33Single6PS6Timolol6PS6-β2-Timolol
13.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
13.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
13.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
13.33Single7WC6LSD7WC6-5-HT2A-LSD
13.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
13.33Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
13.33Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
13.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
13.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
13.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
13.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
13.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.33Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
13.33Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
13.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
13.33Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
13.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.04Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.04Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.90Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
12.90Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
12.90Single6E59L-7607356E59-NK1-L-760735
12.90Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.90Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
12.90Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
12.90Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
12.90Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
12.90Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
12.90Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.90Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
12.90Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
12.90Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
12.90Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
12.90Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.90Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
12.90Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
12.82Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
12.82Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
12.50Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.50Single6CM4Risperidone6CM4-D2-Risperidone
12.50Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
12.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.50Single6HLPNetupitant6HLP-NK1-Netupitant
12.50Single6IIURamatroban6IIU-TP-Ramatroban
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.50Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.50Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
12.50Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
12.50Consensusgi_class-fOther Ligandgi_frizzled
12.50Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.12Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.12Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
12.12Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
12.12Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
12.12Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
12.12Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
12.12Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.12Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
12.12Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.12Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.12Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
12.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.76Single7SK9CCX6627SK9-ACKR3-CCX662
11.76Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
11.54Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.54Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
11.54Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
11.54Single8GGREpinephrine8GGR-β2-Epinephrine
11.54Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
11.54Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.54Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.54Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.43Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.43Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
11.43Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.36Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.11Single3PBLEticlopride3PBL-D3-Eticlopride
11.11Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.11Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
11.11Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7SRQLSD7SRQ-5-HT2B-LSD
11.11Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
11.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
11.11Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
11.11Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
11.11Single8GGSEpinephrine8GGS-β2-Epinephrine
11.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.11Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.11Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
11.11Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
11.11Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.11Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.71Single6AKYMaraviroc6AKY-CCR5-Maraviroc
10.71Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.71Single6KUXRS-799486KUX-α2a-RS-79948
10.71Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
10.71Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
10.71Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
10.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.71Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
10.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
10.71Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
10.71Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
10.71Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
10.71Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8GGVEpinephrine8GGV-β2-Epinephrine
10.71Single8GGWEpinephrine8GGW-β2-Epinephrine
10.71Single8GGXEpinephrine8GGX-β2-Epinephrine
10.71Single8GH0Epinephrine8GH0-β2-Epinephrine
10.71Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8IWESpermidine8IWE-TAAR9-Spermidine
10.71Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.71Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.71Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.71Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
10.71Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
10.71Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
10.71Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
10.71Consensusgt_class-aOrthosteric Ligandgt_opsin
10.71Consensusgt_opsinOrthosteric Ligandgt_sensory
10.71Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
10.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
10.53Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.34Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.34Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
10.34Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.34Single6TPNHTL66416TPN-OX2-HTL6641
10.34Single6VI4JDTic6VI4-κ-JDTic
10.34Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.34Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
10.34Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.34Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
10.34Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
10.34Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
10.34Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
10.34Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
10.34Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
10.34Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
10.34Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
10.34Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
10.34Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
10.34Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
10.34Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.34Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.34Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.34Single8GGIEpinephrine8GGI-β2-Epinephrine
10.34Single8GGLEpinephrine8GGL-β2-Epinephrine
10.34Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
10.34Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
10.34Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
10.34Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
10.34Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
10.34Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.34Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
10.34Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
10.34Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
10.34Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
10.34Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
10.34Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.34Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.26Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6H7MSalbutamol6H7M-β1-Salbutamol
10.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
10.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
10.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
10.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
10.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
10.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
10.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
10.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Single8X63Mepyramine8X63-H1-Mepyramine
10.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
10.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
10.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
10.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Consensusleuko_onOrthosteric Ligandblt_on
10.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
10.00Consensustachykinin_offOrthosteric Ligandnk1_off
10.00Consensustar_onOrthosteric Ligandta1_on
9.76Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.76Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.68Single4NTJAZD12834NTJ-P2Y12-AZD1283
9.68Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
9.68Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.68Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
9.68Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.68Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.68Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.68Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
9.68Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
9.68Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.68Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
9.52Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
9.38Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
9.38Single5V54Methiothepin5V54-5-HT1B-Methiothepin
9.38Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.38Single7EPENAM5637EPE-mGlu-NAM563
9.38Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
9.38Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.38Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.38Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
9.38Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
9.38Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
9.38Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
9.38Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.38Consensus5ht1_offOrthosteric Ligand5ht1b_off
9.38Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.38Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
9.38Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
9.38Consensushistamine_offOrthosteric Ligandh1_off
9.09Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.09Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.82Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.82Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.82Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single6W25Ca6W25-MC4-SHU9119-Ca
8.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
8.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.00Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
8.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.00Consensusclass-c_onOther Ligandgabab_on mglu_on
7.84Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.69Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
7.69Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.69Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.69Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensussensory_onOrthosteric Ligandopsin_on
7.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.41Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.41Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
7.41Single6ME9Ramelteon6ME9-MT2-Ramelteon
7.41Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
7.41Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
7.41Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
7.41Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
7.41Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
7.41Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.41Single8GGZEpinephrine8GGZ-β2-Epinephrine
7.41Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
7.41Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
7.41Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
7.41Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
7.14Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.14Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
7.14Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
7.14Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
7.14Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
7.14Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8GGYEpinephrine8GGY-β2-Epinephrine
7.14Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
7.14Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
7.14Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
7.14Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
6.90Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.90Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
6.90Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
6.90Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
6.90Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.90Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
6.90Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
6.90Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.90Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.90Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
6.90Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
6.90Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
6.90Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
6.90Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.90Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
6.90Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.90Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.90Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.67Single3RZECidoxepin3RZE-H1-Cidoxepin
6.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.67Single6A94Zotepine6A94-5-HT2A-Zotepine
6.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
6.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
6.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
6.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
6.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
6.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
6.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
6.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.67Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
6.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
6.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
6.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
6.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
6.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
6.67Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
6.67Consensussensory_offOrthosteric Ligandopsin_off
6.45Single4DAJTiotropium4DAJ-M3-Tiotropium
6.45Single4MQSIperoxo4MQS-M2-Iperoxo
6.45Single4U14Tiotropium4U14-M3-Tiotropium
6.45Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
6.45Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
6.45Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
6.45Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
6.45Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.45Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Single8X64Desloratadine8X64-H1-Desloratadine
6.45Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
6.45Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
6.45Consensushistamine_onOrthosteric Ligandh1_on h4_on
6.45Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.45Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.45Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
6.25Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
6.25Single5CGCHTL142425CGC-mGlu5-HTL14242
6.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
6.25Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
6.25Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single8EA0Iperoxo8EA0-M3-Iperoxo
6.25Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.25Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.25Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
6.25Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.06Single4U15Tiotropium4U15-M3-Tiotropium
6.06Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
6.06Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
6.06Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
6.06Single6OL9Tiotropium6OL9-M5-Tiotropium
6.06Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
6.06Single7P2L4YI7P2L-mGlu5-4YI
6.06Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
6.06Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
6.06Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
6.06Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
6.06Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
5.88Single5CXVTiotropium5CXV-M1-Tiotropium
5.88Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
5.71Single5CGDHTL142425CGD-mGlu5-HTL14242
5.56Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single6D35Cholesterol6D35-SMO-Cholesterol
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.55Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.55Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.55Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.55Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.55Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
4.55Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7FIIhCG7FII-LH-hCG-6fuf
4.55Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.55Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.55Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.55Single7XW7K1-707XW7-TSH-K1-70
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.55Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.55Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
4.55Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.55Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
4.55Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.55Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.55Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.55Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.55Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
4.55Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
4.55Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensusgphr_onOrthosteric Ligandlh_on tsh_on
4.55Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Consensusgs_proteinOrthosteric Ligandgs_gphr
4.55Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.55Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
4.55Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.55Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.55Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
4.55Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.55Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.55Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
4.55Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.55Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
4.55Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.55Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
4.55Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.55Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
4.55Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.44Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.44Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.44Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.44Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.44Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.26Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
4.17Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.17Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.17Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
4.17Single8HS2Fab0468HS2-GPR20-Fab046
4.17Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
4.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
4.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
4.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.00Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
3.85Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
3.85Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
3.85Single5L7DCholesterol5L7D-SMO-Cholesterol
3.85Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
3.85Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.85Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
3.85Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.77Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.70Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
3.70Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
3.70Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
3.70Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
3.57Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.57Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.57Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
3.57Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.57Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
3.57Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
3.57Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Consensush3_on_alloOther Ligand7F61-H3-PF-03654746-Cholesterol
3.45Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.45Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.45Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
3.45Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.45Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
3.45Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.45Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
3.45Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
3.45Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
3.45Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
3.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
3.33Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
3.33Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
3.33Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
3.33Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
3.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.23Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.23Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.23Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.23Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.23Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.23Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
3.12Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.12Single5DSGTiotropium5DSG-M4-Tiotropium
3.12Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
3.03Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
3.03Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
2.94Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
2.08Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 5UIW
Class A
SubFamily Protein
Type Chemokine
SubType CCR5
Species Homo sapiens
Ligand 5P7-CCL5
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.2
Date 2017-06-28
D.O.I. 10.1016/j.immuni.2017.05.002
Net Summary
Imin 3.89
Number of Linked Nodes 352
Number of Links 389
Number of Hubs 48
Number of Links mediated by Hubs 178
Number of Communities 12
Number of Nodes involved in Communities 76
Number of Links involved in Communities 94
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 77541
Length Of Smallest Path 3
Average Path Length 14.5159
Length of Longest Path 34
Minimum Path Strength 1.45
Average Path Strength 7.48928
Maximum Path Strength 18.965
Minimum Path Correlation 0.7
Average Path Correlation 0.938167
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 54.0396
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.42
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePCA
PDB ResiduesL:L:?0
Environment DetailsOpen EMBL-EBI Page
CodePCA
NamePidolic acid
Synonyms5-L-oxoproline
Identifier(2S)-5-oxopyrrolidine-2-carboxylic acid
FormulaC5 H7 N O3
Molecular Weight129.114
SMILESC1CC(=O)N[C@@H]1C(=O)O
PubChem7405
Formal Charge0
Total Atoms16
Total Chiral Atoms1
Total Bonds16
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP51681
Sequence
>5UIW_Chain_R
TSEPCQKIN VKQIAARLL PPLYSLVFI FGFVGNMLV ILILINYKR 
LKSMTDIYL LNLAISDLF FLLTVPFWA HYAAAQWDF GNTMCQLLT 
GLYFIGFFS GIFFIILLT IDRYLAVVH AVFALKART VTFGVVTSV 
ITWVVAVFA SLPNIIFTR SQKEGLHYT CSSHFPYSQ YQFWKNFQT 
LKIVILGLV LPLLVMVIC YSGILKTLL REKKRHRDV RLIFTIMIV 
YFLFWAPYN IVLLLNTFQ EFFGLNNCS SSNRLDQAM QVTETLGMT 
HCCINPIIY AFVGEEFRN YLLVFFQKH I


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
ccr5_off5UIW-CCR5-5P7-CCL5

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4MBSAProteinChemokineCCR5Homo sapiens-Maraviroc-2.712013-09-1110.1126/science.1241475
5UIWAProteinChemokineCCR5Homo sapiens5P7-CCL5--2.22017-06-2810.1016/j.immuni.2017.05.002
6AKXAProteinChemokineCCR5Homo sapiens-A4R-2.82018-10-2410.1021/acs.jmedchem.8b01077
6AKYAProteinChemokineCCR5Homo sapiens-Maraviroc-2.82018-10-2410.1021/acs.jmedchem.8b01077
6MEOAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--3.92018-12-1210.1038/s41586-018-0804-9
6METAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--4.52018-12-1210.1038/s41586-018-0804-9
7F1QAProteinChemokineCCR5Homo sapiensMIP-1a-Gi1/&β;1/&γ;22.92021-07-1410.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/&β;1/&γ;232021-07-1410.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/&β;1/&γ;22.82021-07-1410.1038/s41467-021-24438-5
7F1TAProteinChemokineCCR5Homo sapiensMIP-1a--2.62021-07-1410.1038/s41467-021-24438-5
7O7FAProteinChemokineCCR5Homo sapiens(6P4)CCL5-Gi1/&β;1/&γ;13.152021-06-3010.1126/sciadv.abg8685




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5UIW.zip



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