psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R70	R:R:T16	5.17	Yes	No	0	4	2
2	R:R:E18	R:R:P19	4.72	Yes	No	0	3	4
3	L:L:R70	R:R:E18	6.98	Yes	Yes	0	4	3
4	R:R:C20	R:R:C269	7.28	No	No	0	9	6
5	R:R:K22	R:R:K26	7.18	Yes	No	1	3	1
6	R:R:K22	R:R:N273	8.39	Yes	No	0	3	1
7	L:L:V30	R:R:K22	7.59	Yes	Yes	1	3	3
8	R:R:Q277	R:R:V25	8.6	No	No	0	1	1
9	L:L:D28	R:R:K26	13.83	Yes	No	1	4	1
10	L:L:V30	R:R:K26	4.55	Yes	No	1	3	1
11	R:R:I28	R:R:Q27	5.49	No	No	0	2	2
12	R:R:A29	R:R:Q280	4.55	No	No	0	5	3
13	L:L:D28	R:R:A30	4.63	Yes	No	0	4	4
14	R:R:L32	R:R:R31	6.07	No	No	0	6	3
15	R:R:L32	R:R:L36	5.54	No	No	0	6	6
16	R:R:L33	R:R:Y37	7.03	No	Yes	0	6	8
17	R:R:L33	R:R:Q280	3.99	No	No	0	6	3
18	R:R:P34	R:R:P35	5.84	No	No	0	6	5
19	R:R:A90	R:R:P34	5.61	No	No	0	5	6
20	R:R:V83	R:R:Y37	5.05	No	Yes	5	7	8
21	R:R:M287	R:R:Y37	4.79	Yes	Yes	5	8	8
22	R:R:F43	R:R:L39	4.87	No	No	0	5	5
23	R:R:M287	R:R:V40	9.13	Yes	No	0	8	7
24	R:R:C291	R:R:V40	3.42	No	No	0	8	7
25	R:R:F41	R:R:I42	3.77	No	No	0	7	5
26	R:R:F41	R:R:F45	9.65	No	Yes	0	7	6
27	R:R:F41	R:R:P84	11.56	No	No	0	7	9
28	R:R:F43	R:R:I42	7.54	No	No	0	5	5
29	R:R:F45	R:R:M49	3.73	Yes	No	0	6	3
30	R:R:G47	R:R:V46	3.68	No	No	0	8	3
31	R:R:D76	R:R:N48	9.42	No	No	0	9	9
32	R:R:N48	R:R:P294	9.77	No	No	0	9	9
33	R:R:F304	R:R:V51	5.24	Yes	No	0	8	8
34	R:R:I52	R:R:L77	5.71	No	No	0	7	7
35	R:R:F304	R:R:I54	8.79	Yes	No	0	8	7
36	R:R:F311	R:R:I54	5.02	Yes	No	0	4	7
37	R:R:L55	R:R:L70	6.92	No	No	0	7	6
38	R:R:I56	R:R:N57	5.66	No	No	0	3	4
39	R:R:I56	R:R:R60	3.76	No	No	0	3	5
40	R:R:F311	R:R:N57	4.83	Yes	No	0	4	4
41	R:R:C58	R:R:F311	4.19	No	Yes	0	5	4
42	R:R:K59	R:R:K62	8.62	No	No	0	5	7
43	R:R:F304	R:R:K59	4.96	Yes	No	0	8	5
44	R:R:K59	R:R:Y307	15.53	No	No	0	5	5
45	R:R:L61	R:R:R60	12.15	No	No	0	6	5
46	R:R:D66	R:R:K62	13.83	No	No	0	8	7
47	R:R:R140	R:R:S63	10.54	Yes	No	0	6	7
48	R:R:M64	R:R:Y68	9.58	Yes	Yes	2	6	7
49	R:R:D125	R:R:M64	4.16	Yes	Yes	2	8	6
50	R:R:F144	R:R:M64	4.98	No	Yes	0	3	6
51	R:R:G145	R:R:M64	3.49	No	Yes	2	7	6
52	R:R:L122	R:R:T65	4.42	No	No	0	9	8
53	R:R:D125	R:R:T65	10.12	Yes	No	0	8	8
54	R:R:L121	R:R:Y68	5.86	No	Yes	2	6	7
55	R:R:D125	R:R:Y68	3.45	Yes	Yes	2	8	7
56	R:R:G145	R:R:Y68	4.35	No	Yes	2	7	7
57	R:R:T148	R:R:Y68	3.75	No	Yes	2	6	7
58	R:R:I74	R:R:L70	4.28	No	No	0	6	6
59	R:R:F118	R:R:N71	14.5	Yes	No	0	7	9
60	R:R:N71	R:R:S149	4.47	No	No	0	9	7
61	R:R:L72	R:R:N293	6.87	No	No	0	9	9
62	R:R:F78	R:R:I74	5.02	No	No	0	7	6
63	R:R:G111	R:R:S75	3.71	No	No	0	8	8
64	R:R:S114	R:R:S75	6.52	No	No	0	7	8
65	R:R:G115	R:R:S75	3.71	No	No	0	9	8
66	R:R:C290	R:R:D76	9.34	No	No	0	8	9
67	R:R:F78	R:R:L107	4.87	No	No	0	7	5
68	R:R:F79	R:R:Y108	12.38	Yes	No	0	7	7
69	R:R:F112	R:R:F79	5.36	No	Yes	0	7	7
70	R:R:F79	R:R:M287	3.73	Yes	Yes	0	7	8
71	R:R:C290	R:R:F79	11.17	No	Yes	0	8	7
72	R:R:L80	R:R:M287	7.07	No	Yes	0	6	8
73	R:R:L107	R:R:T82	5.9	No	No	0	5	7
74	R:R:P84	R:R:V83	3.53	No	No	0	9	7
75	R:R:M287	R:R:V83	7.61	Yes	No	5	8	7
76	R:R:F85	R:R:F96	6.43	No	Yes	0	6	7
77	R:R:F85	R:R:L104	12.18	No	No	0	6	5
78	R:R:W86	R:R:Y89	8.68	Yes	Yes	1	7	4
79	R:R:T105	R:R:W86	3.64	Yes	Yes	1	5	7
80	R:R:C178	R:R:W86	6.53	Yes	Yes	1	9	7
81	L:L:P25	R:R:W86	12.16	No	Yes	1	5	7
82	L:L:P26	R:R:W86	16.21	No	Yes	0	1	7
83	L:L:I29	R:R:W86	4.7	Yes	Yes	1	5	7
84	R:R:F96	R:R:H88	5.66	Yes	No	0	7	5
85	R:R:W94	R:R:Y89	9.65	Yes	Yes	1	9	4
86	R:R:C178	R:R:Y89	4.03	Yes	Yes	1	9	4
87	L:L:D28	R:R:Y89	9.2	Yes	Yes	1	4	4
88	L:L:I29	R:R:Y89	6.04	Yes	Yes	1	5	4
89	R:R:H175	R:R:Q93	13.6	No	No	0	1	3
90	R:R:F96	R:R:W94	19.04	Yes	Yes	0	7	9
91	R:R:C101	R:R:W94	7.84	No	Yes	1	9	9
92	R:R:S169	R:R:W94	4.94	Yes	Yes	1	4	9
93	R:R:C178	R:R:W94	19.59	Yes	Yes	1	9	9
94	R:R:F96	R:R:M100	3.73	Yes	No	0	7	6
95	R:R:G97	R:R:K171	3.49	No	No	0	8	2
96	R:R:N98	R:R:Q102	7.92	No	No	0	3	7
97	R:R:N98	R:R:S169	4.47	No	Yes	0	3	4
98	R:R:C101	R:R:S169	3.44	No	Yes	1	9	4
99	R:R:C101	R:R:C178	7.28	No	Yes	1	9	9
100	R:R:Q102	R:R:T167	4.25	No	No	0	7	5
101	R:R:F109	R:R:T105	3.89	No	Yes	0	5	5
102	R:R:T105	R:R:T167	10.99	Yes	No	0	5	5
103	L:L:P25	R:R:T105	5.25	No	Yes	1	5	5
104	R:R:G106	R:R:I164	3.53	No	No	0	5	4
105	R:R:F109	R:R:Y108	8.25	No	No	0	5	7
106	L:L:P26	R:R:Y108	16.69	No	No	0	1	7
107	R:R:G111	R:R:I110	3.53	No	No	0	8	5
108	R:R:I110	R:R:S160	6.19	No	No	0	5	7
109	R:R:F112	R:R:W248	7.02	No	Yes	0	7	9
110	R:R:F113	R:R:F117	5.36	No	Yes	8	7	5
111	R:R:F113	R:R:K197	6.2	No	Yes	0	7	3
112	R:R:F113	R:R:L201	3.65	No	No	8	7	4
113	R:R:F118	R:R:S114	7.93	Yes	No	6	7	7
114	R:R:S114	R:R:W153	12.36	No	No	6	7	9
115	R:R:I116	R:R:Y244	4.84	No	No	7	7	9
116	R:R:I116	R:R:W248	3.52	No	Yes	7	7	9
117	R:R:F117	R:R:T152	5.19	Yes	No	0	5	6
118	R:R:F117	R:R:L201	4.87	Yes	No	8	5	4
119	R:R:F118	R:R:T152	5.19	Yes	No	0	7	6
120	R:R:F118	R:R:W153	7.02	Yes	No	6	7	9
121	R:R:I119	R:R:N293	7.08	No	No	0	8	9
122	R:R:I120	R:R:P206	3.39	No	Yes	0	7	9
123	R:R:I120	R:R:V209	4.61	No	No	0	7	6
124	R:R:L121	R:R:T148	4.42	No	No	2	6	6
125	R:R:L121	R:R:T152	4.42	No	No	0	6	6
126	R:R:L122	R:R:Y297	8.21	No	Yes	0	9	9
127	R:R:M210	R:R:T123	6.02	No	No	0	8	9
128	R:R:C213	R:R:T123	3.38	No	No	0	8	9
129	R:R:T123	R:R:Y214	6.24	No	Yes	0	9	9
130	R:R:D125	R:R:R140	11.91	Yes	Yes	0	8	6
131	R:R:R126	R:R:Y214	6.17	No	Yes	0	9	9
132	R:R:R126	R:R:Y297	6.17	No	Yes	0	9	9
133	R:R:V131	R:R:Y127	12.62	No	No	0	7	8
134	R:R:C213	R:R:Y127	6.72	No	No	0	8	8
135	R:R:A136	R:R:L128	4.73	No	No	0	5	5
136	R:R:A129	R:R:R140	5.53	No	Yes	0	8	6
137	R:R:I217	R:R:V130	4.61	No	No	0	8	8
138	R:R:T220	R:R:V130	4.76	No	No	0	5	8
139	R:R:H132	R:R:V131	4.15	No	No	0	6	7
140	R:R:T220	R:R:V131	4.76	No	No	0	5	7
141	R:R:F144	R:R:T148	7.78	No	No	0	3	6
142	R:R:F158	R:R:V154	5.24	No	No	0	4	4
143	R:R:F166	R:R:I165	10.05	Yes	No	0	5	3
144	R:R:F166	R:R:S180	3.96	Yes	No	0	5	4
145	R:R:F166	R:R:F182	4.29	Yes	Yes	4	5	5
146	R:R:F166	R:R:P183	10.11	Yes	No	4	5	3
147	R:R:F166	R:R:W190	11.02	Yes	Yes	4	5	3
148	R:R:S180	R:R:T167	4.8	No	No	0	4	5
149	R:R:Q170	R:R:R168	8.18	No	No	9	1	4
150	R:R:H181	R:R:R168	10.16	No	No	9	4	4
151	R:R:K171	R:R:S169	4.59	No	Yes	0	2	4
152	R:R:H181	R:R:Q170	7.42	No	No	9	4	1
153	R:R:K171	R:R:Y176	4.78	No	No	0	2	4
154	L:L:F51	R:R:E172	22.15	No	No	0	4	2
155	L:L:L31	R:R:T177	5.9	No	No	0	4	2
156	L:L:Y52	R:R:H181	4.36	No	No	0	3	4
157	R:R:F182	R:R:Y187	7.22	Yes	Yes	0	5	3
158	R:R:F182	R:R:W190	5.01	Yes	Yes	4	5	3
159	R:R:F182	R:R:Q194	7.03	Yes	No	0	5	5
160	R:R:P183	R:R:W190	4.05	No	Yes	4	3	3
161	L:L:P76	R:R:Y184	9.74	No	No	0	9	1
162	L:L:E77	R:R:Y184	6.73	No	No	0	3	1
163	L:L:E77	R:R:S185	4.31	No	No	0	3	3
164	R:R:Q186	R:R:W190	5.48	No	Yes	0	3	3
165	R:R:K191	R:R:Y187	7.17	No	Yes	0	4	3
166	L:L:G55	R:R:Y187	4.35	No	Yes	0	6	3
167	L:L:P60	R:R:Y187	15.3	No	Yes	0	6	3
168	R:R:K191	R:R:Q188	4.07	No	No	0	4	2
169	R:R:F189	R:R:W190	16.04	No	Yes	0	1	3
170	R:R:F193	R:R:W190	9.02	No	Yes	0	3	3
171	R:R:N192	R:R:T259	5.85	No	No	0	3	5
172	R:R:K197	R:R:Q194	6.78	Yes	No	0	3	5
173	L:L:?23	R:R:Q194	7.12	Yes	No	0	5	5
174	R:R:T195	R:R:T259	12.56	No	No	0	5	5
175	L:L:?23	R:R:T195	7.88	Yes	No	0	5	5
176	R:R:I198	R:R:L255	5.71	No	Yes	0	5	6
177	R:R:I200	R:R:V204	4.61	Yes	No	0	5	4
178	R:R:L203	R:R:N252	10.98	No	No	0	8	8
179	R:R:P206	R:R:Y244	8.34	Yes	No	0	9	9
180	R:R:F245	R:R:L207	3.65	No	No	0	5	6
181	R:R:I237	R:R:Y214	6.04	No	Yes	0	8	9
182	R:R:I240	R:R:Y214	6.04	No	Yes	0	8	9
183	R:R:M241	R:R:Y214	7.18	No	Yes	0	8	9
184	R:R:L218	R:R:V234	4.47	No	No	0	4	6
185	R:R:I237	R:R:L218	7.14	No	No	0	8	4
186	R:R:F238	R:R:L218	3.65	No	No	0	5	4
187	R:R:K229	R:R:N226	8.39	No	No	0	6	4
188	R:R:E227	R:R:R230	8.14	No	No	0	3	7
189	R:R:I240	R:R:L236	4.28	No	No	0	8	8
190	R:R:L236	R:R:V300	7.45	No	No	0	8	7
191	R:R:W248	R:R:Y244	8.68	Yes	No	7	9	9
192	R:R:A249	R:R:F245	5.55	No	No	0	6	5
193	R:R:F247	R:R:L246	4.87	No	No	0	8	5
194	R:R:F247	R:R:T288	6.49	No	No	0	8	5
195	R:R:F247	R:R:H289	9.05	No	No	0	8	9
196	R:R:G286	R:R:W248	5.63	No	Yes	0	8	9
197	R:R:H289	R:R:W248	14.81	No	Yes	0	9	9
198	R:R:P250	R:R:T282	3.5	No	No	0	9	7
199	R:R:N252	R:R:Y251	3.49	No	Yes	0	8	7
200	R:R:L255	R:R:Y251	14.07	Yes	Yes	0	6	7
201	R:R:T282	R:R:Y251	8.74	No	Yes	0	7	7
202	R:R:E283	R:R:Y251	12.35	No	Yes	0	6	7
203	R:R:M279	R:R:V254	9.13	No	No	0	5	5
204	R:R:L255	R:R:M279	5.65	Yes	No	0	6	5
205	L:L:?23	R:R:L255	8.88	Yes	Yes	0	5	6
206	R:R:F264	R:R:L257	4.87	No	No	0	1	4
207	R:R:L257	R:R:L266	4.15	No	No	0	4	4
208	R:R:L257	R:R:L275	5.54	No	No	0	4	5
209	R:R:N258	R:R:Q261	3.96	No	Yes	11	4	4
210	R:R:L275	R:R:N258	5.49	No	No	11	5	4
211	R:R:M279	R:R:N258	4.21	No	No	0	5	4
212	R:R:F260	R:R:T259	5.19	No	No	0	5	5
213	R:R:F260	R:R:F263	12.86	No	No	0	5	1
214	R:R:L266	R:R:Q261	3.99	No	Yes	0	4	4
215	R:R:Q261	R:R:S272	5.78	Yes	No	0	4	3
216	R:R:L275	R:R:Q261	6.65	No	Yes	11	5	4
217	R:R:L266	R:R:S271	7.51	No	No	0	4	1
218	R:R:N267	R:R:N268	4.09	No	No	0	3	4
219	R:R:N268	R:R:S271	4.47	No	No	0	4	1
220	R:R:C269	R:R:N273	4.72	No	No	0	6	1
221	L:L:F35	R:R:S272	3.96	No	No	0	5	3
222	L:L:V30	R:R:D276	14.61	Yes	No	0	3	4
223	L:L:V30	R:R:Q280	5.73	Yes	No	0	3	3
224	L:L:P26	R:R:E283	4.72	No	No	0	1	6
225	R:R:C291	R:R:I292	4.91	No	No	0	8	6
226	R:R:N293	R:R:Y297	5.81	No	Yes	0	9	9
227	R:R:F299	R:R:I295	6.28	No	No	0	7	6
228	R:R:I296	R:R:Y297	3.63	No	Yes	0	8	9
229	R:R:F299	R:R:F304	6.43	No	Yes	0	7	8
230	R:R:F299	R:R:L308	3.65	No	No	0	7	6
231	R:R:E302	R:R:F304	5.83	No	Yes	0	5	8
232	L:L:?23	L:L:G24	7.32	Yes	No	0	5	4
233	L:L:?23	L:L:K56	10.56	Yes	No	0	5	3
234	L:L:G24	L:L:P25	4.06	No	No	0	4	5
235	L:L:G27	L:L:I29	3.53	No	Yes	0	3	5
236	L:L:D28	L:L:I29	4.2	Yes	Yes	1	4	5
237	L:L:C33	L:L:C57	7.28	No	No	0	9	9
238	L:L:A61	L:L:C34	3.61	No	No	0	8	9
239	L:L:C34	L:L:C73	7.28	No	No	0	9	9
240	L:L:N75	L:L:Y37	9.3	Yes	No	0	6	6
241	L:L:P41	L:L:W80	18.92	No	Yes	3	4	8
242	L:L:P41	L:L:Y84	6.95	No	Yes	3	4	4
243	L:L:L42	L:L:P43	4.93	No	No	0	6	7
244	L:L:R44	L:L:Y84	13.38	No	Yes	0	4	4
245	L:L:R44	L:L:S87	7.91	No	No	0	4	3
246	L:L:H46	L:L:T66	4.11	No	No	0	4	9
247	L:L:H46	L:L:R67	13.54	No	No	0	4	5
248	L:L:F64	L:L:I47	5.02	No	No	0	8	7
249	L:L:K48	L:L:N69	4.2	No	No	0	2	5
250	L:L:V62	L:L:Y50	5.05	Yes	Yes	12	8	7
251	L:L:F64	L:L:Y50	4.13	No	Yes	12	8	7
252	L:L:L88	L:L:Y50	7.03	No	Yes	0	7	7
253	L:L:F51	L:L:V63	14.42	No	No	10	4	8
254	L:L:F51	L:L:Q71	8.2	No	Yes	10	4	3
255	L:L:V62	L:L:Y52	5.05	Yes	No	0	8	3
256	L:L:K56	L:L:S54	4.59	No	No	0	3	7
257	L:L:C57	L:L:S54	3.44	No	No	0	9	7
258	L:L:N59	L:L:S58	5.96	No	No	0	4	5
259	L:L:F64	L:L:V62	5.24	No	Yes	12	8	8
260	L:L:Q71	L:L:V63	5.73	Yes	No	10	3	8
261	L:L:K68	L:L:T66	9.01	No	No	0	4	9
262	L:L:K68	L:L:R70	13.61	No	Yes	0	4	4
263	L:L:A74	L:L:V81	5.09	No	No	0	8	9
264	L:L:N75	L:L:P76	6.52	Yes	No	0	6	9
265	L:L:E77	L:L:N75	3.94	No	Yes	0	3	6
266	L:L:K78	L:L:N75	4.2	No	Yes	0	3	6
267	L:L:K78	L:L:W80	9.28	No	Yes	3	3	8
268	L:L:K78	L:L:V81	6.07	No	No	3	3	9
269	L:L:V81	L:L:W80	12.26	No	Yes	3	9	8
270	L:L:W80	L:L:Y84	7.72	Yes	Yes	3	8	4
271	L:L:N86	L:L:R82	9.64	No	No	0	4	8
272	L:L:E83	L:L:Y84	4.49	No	Yes	0	4	4
273	R:R:L205	R:R:P206	3.28	No	Yes	0	6	9
274	L:L:S54	R:R:S179	3.26	No	No	0	7	3
275	R:R:A73	R:R:I52	3.25	No	No	0	9	7
276	R:R:S179	R:R:T177	3.2	No	No	0	3	2
277	R:R:T141	R:R:T143	3.14	No	No	0	6	4
278	R:R:I164	R:R:S160	3.1	No	No	0	4	7
279	R:R:I110	R:R:V157	3.07	No	No	0	5	4
280	R:R:I124	R:R:V209	3.07	No	No	0	7	6
281	R:R:I200	R:R:V199	3.07	Yes	No	0	5	5
282	R:R:I296	R:R:V243	3.07	No	No	0	8	6
283	L:L:I85	L:L:V62	3.07	No	Yes	0	6	8
284	R:R:K22	R:R:V25	3.04	Yes	No	0	3	1
285	R:R:M241	R:R:V211	3.04	No	No	0	8	4
286	L:L:I47	L:L:T66	3.04	No	No	0	7	9
287	R:R:F109	R:R:G163	3.01	No	No	0	5	4
288	R:R:G301	R:R:R305	3	No	No	0	8	8
289	R:R:N24	R:R:V25	2.96	No	No	0	1	1
290	R:R:L36	R:R:T284	2.95	No	No	0	6	6
291	R:R:I292	R:R:I295	2.94	No	No	0	6	6
292	R:R:G216	R:R:Y127	2.9	No	No	0	4	8
293	R:R:Q186	R:R:S185	2.89	No	No	0	3	3
294	L:L:P41	L:L:R40	2.88	No	No	0	4	4
295	R:R:I200	R:R:L201	2.85	Yes	No	0	5	4
296	R:R:I217	R:R:L221	2.85	No	No	0	8	8
297	L:L:I38	L:L:L42	2.85	No	No	0	3	6
298	L:L:E49	L:L:V65	2.85	No	No	0	6	5
299	R:R:L50	R:R:M49	2.83	No	No	0	6	3
300	R:R:A156	R:R:F117	2.77	No	Yes	0	7	5
301	R:R:A136	R:R:R140	2.77	No	Yes	0	5	6
302	R:R:L203	R:R:L207	2.77	No	No	0	8	6
303	R:R:A298	R:R:F304	2.77	No	Yes	0	7	8
304	R:R:L53	R:R:N57	2.75	No	No	0	4	4
305	R:R:I23	R:R:Q27	2.74	No	No	0	3	2
306	L:L:C34	L:L:Y37	2.69	No	No	0	9	6
307	R:R:A87	R:R:Y37	2.67	No	Yes	0	6	8
308	L:L:Q71	R:R:L174	2.66	Yes	No	0	3	4
309	R:R:E262	R:R:N267	2.63	No	No	0	3	3
310	R:R:F158	R:R:V157	2.62	No	No	0	4	4
311	L:L:R70	L:L:V72	2.62	Yes	No	0	4	6
312	R:R:E18	R:R:Q21	2.55	Yes	No	0	3	1
313	L:L:Q71	R:R:E18	2.55	Yes	Yes	0	3	3
314	R:R:I28	R:R:R31	2.51	No	No	0	2	3
315	R:R:F135	R:R:K138	2.48	No	No	0	5	3
316	R:R:F311	R:R:K314	2.48	Yes	No	0	4	6
317	R:R:E227	R:R:H231	2.46	No	No	0	3	5
318	R:R:F45	R:R:L77	2.44	Yes	No	0	6	7
319	R:R:T82	R:R:W86	2.43	No	Yes	0	7	7
320	R:R:I67	R:R:Y68	2.42	No	Yes	0	7	7
321	R:R:N98	R:R:R168	2.41	No	No	0	3	4
322	R:R:K303	R:R:Y307	2.39	No	No	0	6	5
323	L:L:I38	L:L:W80	2.35	No	Yes	0	3	8
324	L:L:N59	L:L:Y37	2.33	No	No	0	4	6
325	R:R:D95	R:R:Y176	2.3	No	No	0	3	4
326	R:R:G202	R:R:P206	2.03	No	Yes	0	6	9
327	R:R:C291	R:R:G44	1.96	No	No	0	8	8
328	R:R:G216	R:R:S215	1.86	No	No	0	4	3
329	R:R:A30	R:R:A90	1.79	No	No	0	4	5
330	R:R:G216	R:R:K219	1.74	No	No	0	4	3
331	R:R:G47	R:R:L50	1.71	No	No	0	8	6
332	R:R:G286	R:R:L285	1.71	No	No	0	8	8
333	R:R:A278	R:R:V254	1.7	No	No	0	6	5
334	L:L:C57	L:L:T53	1.69	No	No	0	9	9
335	R:R:K197	R:R:P162	1.67	Yes	No	0	3	8
336	R:R:L36	R:R:P35	1.64	No	No	0	6	5
337	R:R:L161	R:R:P162	1.64	No	No	0	4	8
338	R:R:E172	R:R:G173	1.64	No	No	0	2	1
339	L:L:E49	R:R:G173	1.64	No	No	0	6	1
340	R:R:S149	R:R:V146	1.62	No	No	0	7	4
341	R:R:S149	R:R:V150	1.62	No	No	0	7	4
342	R:R:A249	R:R:I253	1.62	No	No	0	6	6
343	R:R:A159	R:R:K197	1.61	No	Yes	0	5	3
344	R:R:V142	R:R:V146	1.6	No	No	0	2	4
345	R:R:V146	R:R:V147	1.6	No	No	0	4	1
346	R:R:A298	R:R:L69	1.58	No	No	0	7	8
347	R:R:A233	R:R:L221	1.58	No	No	0	8	8
348	R:R:I42	R:R:S38	1.55	No	No	0	5	3
349	R:R:I151	R:R:V155	1.54	No	No	0	3	4
350	R:R:A92	R:R:Q93	1.52	No	No	0	4	3
351	L:L:K48	L:L:V65	1.52	No	No	0	2	5
352	R:R:G301	R:R:R232	1.5	No	No	0	8	7
353	L:L:A45	L:L:H46	1.46	No	No	0	2	4
354	R:R:I200	R:R:L196	1.43	Yes	No	0	5	4
355	L:L:I85	L:L:N86	1.42	No	No	0	6	4
356	R:R:R274	R:R:S270	1.32	No	No	0	2	1
357	R:R:D95	R:R:Q93	1.31	No	No	0	3	3
358	R:R:F117	R:R:V155	1.31	Yes	No	0	5	4
359	R:R:R230	R:R:V234	1.31	No	No	0	7	6
360	R:R:F144	R:R:T141	1.3	No	No	0	3	6
361	R:R:R235	R:R:T239	1.29	No	No	0	5	5
362	R:R:F45	R:R:L81	1.22	Yes	No	0	6	5
363	R:R:N306	R:R:R305	1.21	No	No	0	5	8
364	R:R:F135	R:R:H132	1.13	No	No	0	5	6
365	L:L:E89	L:L:Y50	1.12	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E18	4.2	4	0	3
2	R:R:K22	6.55	4	1	3
3	R:R:Y37	4.885	4	5	8
4	R:R:F45	4.26	4	0	6
5	R:R:M64	5.5525	4	2	6
6	R:R:Y68	4.90167	6	2	7
7	R:R:F79	8.16	4	0	7
8	R:R:W86	7.76429	7	1	7
9	R:R:Y89	7.52	5	1	4
10	R:R:W94	12.212	5	1	9
11	R:R:F96	8.715	4	0	7
12	R:R:T105	5.9425	4	1	5
13	R:R:F117	3.9	5	8	5
14	R:R:F118	8.66	4	6	7
15	R:R:D125	7.41	4	2	8
16	R:R:R140	7.6875	4	0	6
17	R:R:F166	7.886	5	4	5
18	R:R:S169	4.36	4	1	4
19	R:R:C178	9.3575	4	1	9
20	R:R:F182	5.8875	4	4	5
21	R:R:Y187	8.51	4	0	3
22	R:R:W190	8.43667	6	4	3
23	R:R:K197	4.065	4	0	3
24	R:R:I200	2.99	4	0	5
25	R:R:P206	4.26	4	0	9
26	R:R:Y214	6.334	5	0	9
27	R:R:W248	7.932	5	7	9
28	R:R:Y251	9.6625	4	0	7
29	R:R:L255	8.5775	4	0	6
30	R:R:Q261	5.095	4	11	4
31	R:R:M287	6.466	5	5	8
32	R:R:Y297	5.955	4	0	9
33	R:R:F304	5.67	6	0	8
34	R:R:F311	4.13	4	0	4
35	L:L:?23	8.352	5	0	5
36	L:L:D28	7.965	4	1	4
37	L:L:I29	4.6175	4	1	5
38	L:L:V30	8.12	4	1	3
39	L:L:Y50	4.3325	4	12	7
40	L:L:V62	4.6025	4	12	8
41	L:L:R70	7.095	4	0	4
42	L:L:Q71	4.785	4	10	3
43	L:L:N75	5.99	4	0	6
44	L:L:W80	10.106	5	3	8
45	L:L:Y84	8.135	4	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R70	R:R:E18	12.5923	6.98	Yes	Yes	0	4	3
2	L:L:K68	L:L:R70	15.345	13.61	No	Yes	0	4	4
3	L:L:K68	L:L:T66	16.2696	9.01	No	No	0	4	9
4	L:L:I47	L:L:T66	19.9154	3.04	No	No	0	7	9
5	L:L:F64	L:L:I47	20.8137	5.02	No	No	0	8	7
6	L:L:F64	L:L:V62	21.5124	5.24	No	Yes	12	8	8
7	L:L:V62	L:L:Y52	27.7455	5.05	Yes	No	0	8	3
8	L:L:Y52	R:R:H181	28.5493	4.36	No	No	0	3	4
9	R:R:H181	R:R:R168	29.3294	10.16	No	No	9	4	4
10	R:R:N98	R:R:R168	31.0893	2.41	No	No	0	3	4
11	R:R:N98	R:R:S169	12.6973	4.47	No	Yes	0	3	4
12	R:R:S169	R:R:W94	17.5567	4.94	Yes	Yes	1	4	9
13	R:R:W94	R:R:Y89	14.5413	9.65	Yes	Yes	1	9	4
14	L:L:D28	R:R:Y89	18.5443	9.2	Yes	Yes	1	4	4
15	L:L:D28	R:R:K26	17.5672	13.83	Yes	No	1	4	1
16	L:L:D28	R:R:A30	18.1424	4.63	Yes	No	0	4	4
17	R:R:A30	R:R:A90	16.5191	1.79	No	No	0	4	5
18	R:R:A90	R:R:P34	14.8906	5.61	No	No	0	5	6
19	R:R:P34	R:R:P35	13.2568	5.84	No	No	0	6	5
20	R:R:L36	R:R:P35	11.6178	1.64	No	No	0	6	5
21	R:R:N98	R:R:Q102	26.4164	7.92	No	No	0	3	7
22	R:R:Q102	R:R:T167	27.0101	4.25	No	No	0	7	5
23	R:R:T105	R:R:T167	27.0442	10.99	Yes	No	0	5	5
24	R:R:F109	R:R:T105	34.0732	3.89	No	Yes	0	5	5
25	R:R:F109	R:R:Y108	33.0278	8.25	No	No	0	5	7
26	R:R:F79	R:R:Y108	86.0681	12.38	Yes	No	0	7	7
27	R:R:F79	R:R:M287	62.1838	3.73	Yes	Yes	0	7	8
28	R:R:M287	R:R:V83	21.5571	7.61	Yes	No	5	8	7
29	R:R:P84	R:R:V83	21.3076	3.53	No	No	0	9	7
30	R:R:F41	R:R:P84	19.918	11.56	No	No	0	7	9
31	R:R:M287	R:R:V40	37.6954	9.13	Yes	No	0	8	7
32	R:R:C291	R:R:V40	36.3006	3.42	No	No	0	8	7
33	R:R:F41	R:R:F45	12.8917	9.65	No	Yes	0	7	6
34	R:R:C291	R:R:I292	33.4953	4.91	No	No	0	8	6
35	R:R:I292	R:R:I295	32.0848	2.94	No	No	0	6	6
36	R:R:F299	R:R:I295	30.669	6.28	No	No	0	7	6
37	R:R:F299	R:R:F304	27.8716	6.43	No	Yes	0	7	8
38	R:R:F304	R:R:I54	13.4328	8.79	Yes	No	0	8	7
39	R:R:F311	R:R:I54	12.0013	5.02	Yes	No	0	4	7
40	R:R:T105	R:R:W86	10.3307	3.64	Yes	Yes	1	5	7
41	R:R:W86	R:R:Y89	26.3692	8.68	Yes	Yes	1	7	4
42	R:R:C178	R:R:W94	10.856	19.59	Yes	Yes	1	9	9
43	R:R:C178	R:R:W86	18.5968	6.53	Yes	Yes	1	9	7
44	R:R:S180	R:R:T167	30.5009	4.8	No	No	0	4	5
45	R:R:F166	R:R:S180	30.388	3.96	Yes	No	0	5	4
46	R:R:F166	R:R:F182	14.8328	4.29	Yes	Yes	4	5	5
47	R:R:F182	R:R:Q194	25.1661	7.03	Yes	No	0	5	5
48	R:R:K197	R:R:Q194	100	6.78	Yes	No	0	3	5
49	R:R:F113	R:R:K197	96.2596	6.2	No	Yes	0	7	3
50	R:R:F113	R:R:F117	89.4802	5.36	No	Yes	8	7	5
51	R:R:F117	R:R:T152	86.5409	5.19	Yes	No	0	5	6
52	R:R:L121	R:R:T152	65.5276	4.42	No	No	0	6	6
53	R:R:L121	R:R:Y68	59.4416	5.86	No	Yes	2	6	7
54	R:R:D125	R:R:Y68	54.9211	3.45	Yes	Yes	2	8	7
55	R:R:D125	R:R:T65	48.4831	10.12	Yes	No	0	8	8
56	R:R:L122	R:R:T65	47.3011	4.42	No	No	0	9	8
57	R:R:F118	R:R:T152	25.3001	5.19	Yes	No	0	7	6
58	R:R:L122	R:R:Y297	46.0928	8.21	No	Yes	0	9	9
59	R:R:F118	R:R:S114	14.8486	7.93	Yes	No	6	7	7
60	R:R:S114	R:R:S75	13.551	6.52	No	No	0	7	8
61	R:R:G111	R:R:S75	10.8823	3.71	No	No	0	8	8
62	R:R:F112	R:R:F79	23.3642	5.36	No	Yes	0	7	7
63	L:L:P25	R:R:T105	23.0254	5.25	No	Yes	1	5	5
64	L:L:P26	R:R:W86	42.3446	16.21	No	Yes	0	1	7
65	R:R:K171	R:R:S169	16.3248	4.59	No	Yes	0	2	4
66	R:R:K171	R:R:Y176	11.6861	4.78	No	No	0	2	4
67	R:R:F112	R:R:W248	21.9432	7.02	No	Yes	0	7	9
68	R:R:W248	R:R:Y244	10.3675	8.68	Yes	No	7	9	9
69	R:R:R126	R:R:Y297	38.8774	6.17	No	Yes	0	9	9
70	R:R:R126	R:R:Y214	37.6455	6.17	No	Yes	0	9	9
71	R:R:T123	R:R:Y214	21.473	6.24	No	Yes	0	9	9
72	R:R:C213	R:R:T123	18.8621	3.38	No	No	0	8	9
73	R:R:C213	R:R:Y127	17.5488	6.72	No	No	0	8	8
74	R:R:V131	R:R:Y127	12.2429	12.62	No	No	0	7	8
75	R:R:F166	R:R:W190	15.2005	11.02	Yes	Yes	4	5	3
76	L:L:?23	L:L:K56	10.7142	10.56	Yes	No	0	5	3
77	L:L:?23	L:L:G24	73.6256	7.32	Yes	No	0	5	4
78	L:L:G24	L:L:P25	73.9198	4.06	No	No	0	4	5
79	L:L:E77	R:R:S185	21.5124	4.31	No	No	0	3	3
80	R:R:Q186	R:R:S185	22.3635	2.89	No	No	0	3	3
81	R:R:Q186	R:R:W190	23.1961	5.48	No	Yes	0	3	3
82	L:L:E77	L:L:N75	18.9567	3.94	No	Yes	0	3	6
83	L:L:?23	R:R:L255	34.9584	8.88	Yes	Yes	0	5	6
84	L:L:P26	R:R:E283	34.5696	4.72	No	No	0	1	6
85	R:R:E283	R:R:Y251	34.173	12.35	No	Yes	0	6	7
86	R:R:L255	R:R:M279	18.1477	5.65	Yes	No	0	6	5
87	R:R:M279	R:R:N258	14.6017	4.21	No	No	0	5	4
88	L:L:K78	L:L:N75	12.0459	4.2	No	Yes	0	3	6
89	L:L:D28	L:L:I29	15.064	4.2	Yes	Yes	1	4	5
90	L:L:I29	R:R:W86	16.372	4.7	Yes	Yes	1	5	7
91	L:L:P25	R:R:W86	51.3015	12.16	No	Yes	1	5	7
92	L:L:?23	R:R:Q194	87.0742	7.12	Yes	No	0	5	5
93	L:L:P26	R:R:Y108	54.4798	16.69	No	No	0	1	7
94	R:R:L255	R:R:Y251	30.5088	14.07	Yes	Yes	0	6	7
95	R:R:F182	R:R:W190	10.7405	5.01	Yes	Yes	4	5	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R70	R:R:T16	5.17	0	Yes	No	4	2	0	1
R:R:E18	R:R:P19	4.72	0	Yes	No	3	4	1	2
L:L:R70	R:R:E18	6.98	0	Yes	Yes	4	3	0	1
R:R:K22	R:R:K26	7.18	1	Yes	No	3	1	1	1
R:R:K22	R:R:N273	8.39	1	Yes	No	3	1	1	2
L:L:V30	R:R:K22	7.59	1	Yes	Yes	3	3	0	1
L:L:D28	R:R:K26	13.83	1	Yes	No	4	1	0	1
L:L:V30	R:R:K26	4.55	1	Yes	No	3	1	0	1
R:R:A29	R:R:Q280	4.55	0	No	No	5	3	2	1
L:L:D28	R:R:A30	4.63	1	Yes	No	4	4	0	1
R:R:L33	R:R:Q280	3.99	0	No	No	6	3	2	1
R:R:F79	R:R:Y108	12.38	0	Yes	No	7	7	2	1
R:R:W86	R:R:Y89	8.68	1	Yes	Yes	7	4	1	1
R:R:T105	R:R:W86	3.64	1	Yes	Yes	5	7	1	1
R:R:C178	R:R:W86	6.53	1	Yes	Yes	9	7	2	1
L:L:P25	R:R:W86	12.16	1	No	Yes	5	7	0	1
L:L:P26	R:R:W86	16.21	0	No	Yes	1	7	0	1
L:L:I29	R:R:W86	4.7	1	Yes	Yes	5	7	0	1
R:R:W94	R:R:Y89	9.65	1	Yes	Yes	9	4	2	1
R:R:C178	R:R:Y89	4.03	1	Yes	Yes	9	4	2	1
L:L:D28	R:R:Y89	9.2	1	Yes	Yes	4	4	0	1
L:L:I29	R:R:Y89	6.04	1	Yes	Yes	5	4	0	1
R:R:C178	R:R:W94	19.59	1	Yes	Yes	9	9	2	2
R:R:F109	R:R:T105	3.89	0	No	Yes	5	5	2	1
R:R:T105	R:R:T167	10.99	1	Yes	No	5	5	1	2
L:L:P25	R:R:T105	5.25	1	No	Yes	5	5	0	1
R:R:F109	R:R:Y108	8.25	0	No	No	5	7	2	1
L:L:P26	R:R:Y108	16.69	0	No	No	1	7	0	1
R:R:Q170	R:R:R168	8.18	9	No	No	1	4	2	2
R:R:H181	R:R:R168	10.16	9	No	No	4	4	1	2
R:R:H181	R:R:Q170	7.42	9	No	No	4	1	1	2
L:L:F51	R:R:E172	22.15	10	No	No	4	2	0	1
L:L:L31	R:R:T177	5.9	0	No	No	4	2	0	1
L:L:Y52	R:R:H181	4.36	0	No	No	3	4	0	1
R:R:F182	R:R:Y187	7.22	4	Yes	Yes	5	3	2	1
R:R:F182	R:R:Q194	7.03	4	Yes	No	5	5	2	1
L:L:P76	R:R:Y184	9.74	0	No	No	9	1	0	1
L:L:E77	R:R:Y184	6.73	0	No	No	3	1	0	1
L:L:E77	R:R:S185	4.31	0	No	No	3	3	0	1
R:R:K191	R:R:Y187	7.17	0	No	Yes	4	3	2	1
L:L:G55	R:R:Y187	4.35	0	No	Yes	6	3	0	1
L:L:P60	R:R:Y187	15.3	0	No	Yes	6	3	0	1
R:R:K197	R:R:Q194	6.78	0	Yes	No	3	5	2	1
L:L:?23	R:R:Q194	7.12	0	Yes	No	5	5	0	1
R:R:T195	R:R:T259	12.56	0	No	No	5	5	1	2
L:L:?23	R:R:T195	7.88	0	Yes	No	5	5	0	1
R:R:I198	R:R:L255	5.71	0	No	Yes	5	6	2	1
R:R:L255	R:R:Y251	14.07	0	Yes	Yes	6	7	1	2
R:R:E283	R:R:Y251	12.35	0	No	Yes	6	7	1	2
R:R:L255	R:R:M279	5.65	0	Yes	No	6	5	1	2
L:L:?23	R:R:L255	8.88	0	Yes	Yes	5	6	0	1
R:R:Q261	R:R:S272	5.78	11	Yes	No	4	3	2	1
L:L:F35	R:R:S272	3.96	0	No	No	5	3	0	1
L:L:V30	R:R:D276	14.61	1	Yes	No	3	4	0	1
L:L:V30	R:R:Q280	5.73	1	Yes	No	3	3	0	1
L:L:P26	R:R:E283	4.72	0	No	No	1	6	0	1
L:L:S54	R:R:S179	3.26	0	No	No	7	3	0	1
R:R:S179	R:R:T177	3.2	0	No	No	3	2	1	1
R:R:K22	R:R:V25	3.04	1	Yes	No	3	1	1	2
R:R:Q186	R:R:S185	2.89	0	No	No	3	3	2	1
L:L:Q71	R:R:L174	2.66	10	Yes	No	3	4	0	1
R:R:E18	R:R:Q21	2.55	0	Yes	No	3	1	1	2
L:L:Q71	R:R:E18	2.55	10	Yes	Yes	3	3	0	1
R:R:T82	R:R:W86	2.43	0	No	Yes	7	7	2	1
R:R:A30	R:R:A90	1.79	0	No	No	4	5	1	2
R:R:E172	R:R:G173	1.64	0	No	No	2	1	1	1
L:L:E49	R:R:G173	1.64	0	No	No	6	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7O7F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	339
Number of Links	365
Number of Hubs	45
Number of Links mediated by Hubs	169
Number of Communities	12
Number of Nodes involved in Communities	52
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	83863
Length Of Smallest Path	3
Average Path Length	17.4638
Length of Longest Path	46
Minimum Path Strength	1.415
Average Path Strength	6.71026
Maximum Path Strength	19.315
Minimum Path Correlation	0.7
Average Path Correlation	0.947039
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	56.5713
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.8646
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Interleukin 8-like chemokines • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • WD40 repeat-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Interleukin 8-like chemokines • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • WD40 repeat-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?23
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	(S)-(−)-2-pyrrolidone-5-carboxylic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51681
Sequence	>7O7F_nogp_Chain_R T S E P C Q K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C K R L K S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A Q W D F G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H A V F A L K A R T V T F G V V T S V I T W V V A V F A S L P G I I F T R S Q K E G L H Y T C S S H F P Y S Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C R N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G L N N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K F R N Y L L V F F Q K H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	6P4-CCL5
UniProt	P13501
Sequence	>7O7F_nogp_Chain_L ?G P P G D I V L A C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MBS	A	Protein	Chemokine	CCR5	Homo sapiens	-	Maraviroc	-	2.71	2013-09-11	doi.org/10.1126/science.1241475
	5UIW	A	Protein	Chemokine	CCR5	Homo sapiens	5P7-CCL5	-	-	2.2	2017-06-28	doi.org/10.1016/j.immuni.2017.05.002
	6AKX	A	Protein	Chemokine	CCR5	Homo sapiens	-	A4R	-	2.8	2018-10-24	doi.org/10.1021/acs.jmedchem.8b01077
	6AKY	A	Protein	Chemokine	CCR5	Homo sapiens	-	Maraviroc	-	2.8	2018-10-24	doi.org/10.1021/acs.jmedchem.8b01077
	6MEO	A	Protein	Chemokine	CCR5	Homo sapiens	Gp160; CD4	-	-	3.9	2018-12-12	doi.org/10.1038/s41586-018-0804-9
	6MET	A	Protein	Chemokine	CCR5	Homo sapiens	Gp160; CD4	-	-	4.5	2018-12-12	doi.org/10.1038/s41586-018-0804-9
	7O7F	A	Protein	Chemokine	CCR5	Homo sapiens	6P4-CCL5	-	Gi1/β1/γ1	3.15	2021-06-30	doi.org/10.1126/sciadv.abg8685
	7O7F (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	6P4-CCL5	-		3.15	2021-06-30	doi.org/10.1126/sciadv.abg8685
	7F1Q	A	Protein	Chemokine	CCR5	Homo sapiens	CCL3	-	Gi1/β1/γ2	2.9	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1Q (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	CCL3	-		2.9	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1R	A	Protein	Chemokine	CCR5	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1R (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	-	-		3	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1S	A	Protein	Chemokine	CCR5	Homo sapiens	-	-	Gi1/β1/γ2	2.8	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1S (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	-	-		2.8	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1T	A	Protein	Chemokine	CCR5	Homo sapiens	CCL3	-	-	2.6	2021-07-14	doi.org/10.1038/s41467-021-24438-5

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