Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 4.32419
2A:A:V34 5.66475
3A:A:K35 3.84429
4A:A:L38 4.92754218
5A:A:L39 3.725409
6A:A:K46 6.8745219
7A:A:K54 7.7875477
8A:A:F189 11.3475479
9A:A:F191 8.8125475
10A:A:H195 9.375424
11A:A:F196 6.27833677
12A:A:K197 5.55167626
13A:A:M198 3.4525407
14A:A:F199 9.38525
15A:A:Q204 5.545429
16A:A:K209 5.3075428
17A:A:K210 6.884529
18A:A:W211 4.61333629
19A:A:H213 7.6125428
20A:A:C214 5.445427
21A:A:F215 10.56429
22A:A:I221 6.19488
23A:A:I222 6.4975407
24A:A:D229 7.60754168
25A:A:Y230 7.8675498
26A:A:H244 2.86494
27A:A:M247 5.0725496
28A:A:C254 3.9975485
29A:A:W258 7.59167625
30A:A:T262 3.7025487
31A:A:I264 3.2225486
32A:A:I265 4.0925108
33A:A:L266 5.31489
34A:A:F267 4.268336109
35A:A:F274 7.646509
36A:A:K277 8.81499
37A:A:S281 4.84497
38A:A:C286 5.9175496
39A:A:Y287 8.13714797
40A:A:Y296 9.5225404
41A:A:Y320 6.788577107
42A:A:F334 9.25254103
43A:A:F336 6.808578
44A:A:I343 4.738577
45A:A:L348 8.42254209
46A:A:K349 6.26405
47A:A:L353 5.33254207
48B:B:R22 2.6406
49B:B:L30 4.025405
50B:B:V40 3.536513
51B:B:M45 3.77514
52B:B:H54 7.28619
53B:B:K57 8.3775429
54B:B:Y59 8.33714728
55B:B:M61 4.3625416
56B:B:W63 6.83617
57B:B:L70 5.4825415
58B:B:V71 3.74408
59B:B:Q75 7.1875429
60B:B:L79 3.984177
61B:B:I80 7.1975418
62B:B:I81 3.625617
63B:B:W82 7.34857719
64B:B:D83 7.8225418
65B:B:N88 4.33517
66B:B:K89 6.31167619
67B:B:I93 6.1175407
68B:B:L95 4.91754178
69B:B:W99 12.268529
70B:B:M101 3.9125429
71B:B:Y105 4.792506
72B:B:Y111 7.975444
73B:B:C114 4.18754178
74B:B:L117 5.295409
75B:B:I120 4.71406
76B:B:Y124 8.0025176
77B:B:H142 8.35333649
78B:B:Y145 5.48625828
79B:B:L146 3.25333647
80B:B:C148 3.64466
81B:B:C149 3.752548
82B:B:F151 6.29549
83B:B:L152 4.316503
84B:B:T159 4.655649
85B:B:S160 4.42466
86B:B:D163 7.035449
87B:B:C166 3.3925468
88B:B:W169 9.44333648
89B:B:T173 3.3225405
90B:B:F180 8.26167667
91B:B:H183 9.09833669
92B:B:D186 6.82429
93B:B:M188 4.94528
94B:B:L190 4.5375465
95B:B:V200 7.8425456
96B:B:D205 5.9875469
97B:B:K209 9.96833666
98B:B:L210 4.868555
99B:B:W211 8.80571768
100B:B:Q220 9.288557
101B:B:F222 11.7775458
102B:B:H225 10.3117659
103B:B:D228 6.81667629
104B:B:N230 7.8625429
105B:B:I232 4.078558
106B:B:F234 5.445455
107B:B:F235 7.566676126
108B:B:N237 7.2265125
109B:B:F241 7.235656
110B:B:D246 6.7525429
111B:B:D247 5.0825409
112B:B:F253 6.91833656
113B:B:Q259 4.4954236
114B:B:M262 6.46754114
115B:B:Y264 6.78754115
116B:B:T274 4.7775428
117B:B:F278 4.455717127
118B:B:R283 5.22667619
119B:B:L284 5.0675415
120B:B:L286 4.31417
121B:B:Y289 7.006676117
122B:B:D290 8.31426
123B:B:N295 8.4254116
124B:B:V296 4.375415
125B:B:W297 7.4225118
126B:B:D298 4.9375419
127B:B:L300 5.9075416
128B:B:K301 4.595605
129B:B:H311 11.0575419
130B:B:R314 9.576528
131B:B:L318 5.85416
132B:B:T321 7.0825417
133B:B:V327 4.5825416
134B:B:W332 8.7325829
135B:B:L336 5.996517
136B:B:K337 10.7925416
137B:B:I338 4.4075415
138B:B:W339 8.67667619
139B:B:N340 8.63519
140G:G:Y40 11.2254126
141G:G:D48 6.67519
142G:G:L50 4.558519
143G:G:L51 3.614516
144G:G:N59 8.5325419
145G:G:F61 6.99818
146R:R:N48 5.4675439
147R:R:L55 5.8554187
148R:R:K59 8.4954185
149R:R:L61 3.51254186
150R:R:M64 6.85754136
151R:R:Y68 6.8265137
152R:R:S75 4.01254158
153R:R:D76 5.67539
154R:R:F79 8.9275437
155R:R:Y89 7.0075404
156R:R:F112 5.818537
157R:R:F113 4.00143737
158R:R:I116 5.435437
159R:R:F117 3.734535
160R:R:F118 7.415157
161R:R:I119 5.4525438
162R:R:I120 4.668537
163R:R:T123 3.97439
164R:R:D125 8.13754138
165R:R:Y127 7.00754148
166R:R:V131 8.24147
167R:R:H132 5.984146
168R:R:T148 5.4654136
169R:R:W153 8.95254159
170R:R:F182 5.045405
171R:R:W190 7.2025403
172R:R:P206 5.23539
173R:R:V209 3.855436
174R:R:K229 7.4154196
175R:R:Y244 7.32667639
176R:R:F247 6.078508
177R:R:W248 8.5639
178R:R:Y251 7.675407
179R:R:T259 6.3925405
180R:R:H289 11.925439
181R:R:N293 6.744539
182R:R:Y297 6.294539
183R:R:F304 6.2775408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:S16 B:B:N88 12.72682.98NoYes177
2B:B:H54 B:B:S74 20.45179.76YesNo099
3B:B:A56 B:B:S74 20.59423.42NoNo079
4B:B:A56 B:B:D76 20.7381.54NoNo079
5A:A:A30 B:B:D76 21.17111.54NoNo039
6A:A:A30 A:A:K35 21.31851.61NoYes039
7A:A:F199 A:A:K35 10.76514.96YesYes259
8A:A:F199 A:A:F215 11.36035.36YesYes259
9A:A:F215 A:A:L37 99.113115.83YesNo099
10A:A:L37 A:A:L39 99.03892.77NoYes099
11A:A:F223 A:A:L39 1003.65NoYes099
12A:A:F223 A:A:L266 1003.65NoYes899
13A:A:F307 A:A:L266 1009.74NoYes089
14A:A:F307 A:A:M247 1003.73NoYes086
15A:A:H244 A:A:M247 58.29413.94YesYes946
16A:A:C286 A:A:H244 58.32452.95YesYes964
17A:A:C286 A:A:Y230 1005.38YesYes968
18A:A:K277 A:A:Y230 10017.91YesYes998
19A:A:K277 A:A:S228 87.50893.06YesNo099
20A:A:K270 A:A:S228 87.41646.12NoNo099
21A:A:A226 A:A:K270 87.38563.21NoNo089
22A:A:A226 A:A:S44 87.35473.42NoNo1689
23A:A:G45 A:A:S44 1001.86NoNo099
24A:A:G45 A:A:K46 1003.49NoYes099
25A:A:K46 A:A:L38 1002.82YesYes2198
26A:A:L38 A:A:M198 1002.83YesYes087
27A:A:L36 A:A:M198 56.85694.24NoYes077
28A:A:F196 A:A:L36 1003.65YesNo077
29A:A:F196 A:A:V34 1005.24YesYes775
30A:A:I343 A:A:V34 1003.07YesYes775
31A:A:I343 A:A:N347 1004.25YesNo078
32A:A:N347 R:R:A129 1006.25NoNo088
33R:R:A129 R:R:A136 1001.79NoNo085
34R:R:A136 R:R:R140 1002.77NoNo056
35R:R:M64 R:R:R140 83.984112.41YesNo1366
36R:R:M64 R:R:Y68 80.88495.99YesYes1367
37R:R:L121 R:R:Y68 10010.55NoYes1367
38R:R:L121 R:R:T152 1002.95NoNo066
39R:R:F118 R:R:T152 96.6736.49YesNo076
40R:R:F118 R:R:W153 18.14066.01YesYes1579
41R:R:F78 R:R:W153 17.10545.01NoYes079
42R:R:F78 R:R:I74 16.08572.51NoNo076
43R:R:I74 R:R:L70 15.5672.85NoNo066
44B:B:H54 B:B:W82 11.04488.46YesYes199
45A:A:K35 A:A:V218 10.72183.04YesNo099
46A:A:T262 A:A:V218 10.78694.76YesNo079
47A:A:I221 A:A:T262 10.93963.04YesYes887
48A:A:I221 A:A:I264 11.25092.94YesYes886
49A:A:F250 A:A:I264 11.50563.77NoYes896
50A:A:F250 A:A:L266 11.57024.87NoYes899
51A:A:M247 A:A:Y287 58.35138.38YesYes967
52A:A:C286 A:A:Y287 58.397812.1YesYes967
53A:A:F307 A:A:I303 58.16693.77NoNo087
54A:A:I303 A:A:L227 58.14444.28NoNo077
55A:A:F274 A:A:L227 58.180820.7YesNo097
56A:A:F274 A:A:Y230 58.40863.09YesYes098
57A:A:D231 A:A:K277 87.50899.68NoYes099
58A:A:D231 A:A:L232 87.47816.79NoNo098
59A:A:D229 A:A:L232 87.36134.07YesNo1688
60A:A:D229 A:A:S44 87.35475.89YesNo1689
61A:A:I222 A:A:L38 59.42469.99YesYes078
62A:A:I222 A:A:L36 56.85579.99YesNo077
63A:A:F189 A:A:M198 57.45933.73YesYes097
64A:A:F189 A:A:F196 56.790110.72YesYes797
65R:R:D125 R:R:R140 81.399915.48YesNo1386
66R:R:D125 R:R:Y68 80.88685.75YesYes1387
67B:B:D83 B:B:N88 11.5625.39YesYes187
68B:B:D83 B:B:V90 10.91254.38YesNo185
69B:B:I81 B:B:V90 10.02773.07YesNo175
70A:A:L249 A:A:L39 63.14592.77NoYes099
71A:A:F215 A:A:W211 63.05383.01YesYes299
72A:A:R208 A:A:W211 62.88794NoYes099
73A:A:L249 A:A:R208 63.015710.93NoNo099
74A:A:W211 B:B:Y145 1003.86YesYes298
75A:A:K210 B:B:Y145 62.03224.78YesYes298
76A:A:K210 B:B:D228 30.87098.3YesYes299
77B:B:M188 B:B:Y145 61.73753.59YesYes288
78B:B:D228 B:B:M188 30.87424.16YesYes298
79A:A:K210 B:B:N230 30.72368.39YesYes299
80B:B:M188 B:B:N230 30.7274.21YesYes289
81B:B:Q75 B:B:W99 23.96296.57YesYes299
82B:B:Q75 B:B:Y59 19.70413.53YesYes298
83B:B:L318 B:B:S275 12.8453YesNo068
84B:B:S275 B:B:T274 12.91824.8NoYes088
85R:R:F118 R:R:L72 75.01346.09YesNo079
86R:R:I119 R:R:L72 53.7952.85YesNo089
87R:R:I119 R:R:Y297 16.57489.67YesYes389
88R:R:R126 R:R:Y297 13.49714.12NoYes099
89A:A:L353 R:R:R126 12.45897.29YesNo079
90R:R:L55 R:R:L70 10.8974.15YesNo1876
91R:R:D76 R:R:L72 20.7116.79YesNo099
92R:R:D76 R:R:N293 10.37135.39YesYes399
93R:R:I119 R:R:N293 10.34945.66YesYes389
94B:B:C148 B:B:R150 12.05052.79YesNo066
95B:B:C148 B:B:S189 90.13535.16YesNo067
96B:B:I232 B:B:S189 90.7223.1YesNo087
97B:B:S316 B:B:Y59 15.91936.36NoYes298
98B:B:C148 B:B:S160 34.26493.44YesYes666
99B:B:S160 B:B:V187 33.08414.85YesNo069
100B:B:H183 B:B:V187 30.13625.54YesNo099
101B:B:H183 B:B:K209 26.001323.58YesYes696
102B:B:G182 B:B:K209 49.64813.49NoYes066
103B:B:G182 B:B:T181 48.46625.46NoNo062
104B:B:T165 B:B:T181 47.28447.85NoNo072
105B:B:D163 B:B:T165 46.10258.67YesNo097
106B:B:D163 B:B:H142 42.55666.3YesYes499
107B:B:H142 B:B:T159 24.8255.48YesYes499
108B:B:I157 B:B:T159 20.09793.04NoYes479
109B:B:F151 B:B:I157 17.733511.3YesNo497
110B:B:C148 B:B:L190 43.67523.17YesYes665
111B:B:L190 B:B:S201 31.89526.01YesNo659
112B:B:S201 B:B:W211 28.94773.71NoYes698
113B:B:K209 B:B:W211 26.009112.76YesYes668
114B:B:F151 B:B:I123 10.64052.51YesNo496
115B:B:L190 B:B:V158 11.194.47YesNo055
116B:B:L152 B:B:L168 12.98712.77YesNo036
117B:B:L168 B:B:T177 11.80334.42NoNo064
118B:B:D170 B:B:T177 10.624510.12NoNo094
119B:B:I232 B:B:T243 94.15034.56YesNo588
120B:B:H225 B:B:T243 94.728810.95YesNo598
121B:B:H225 B:B:S245 1008.37YesNo099
122B:B:D228 B:B:D246 61.16975.32YesYes299
123B:B:D246 B:B:N230 61.158810.77YesYes299
124B:B:D246 B:B:S227 1005.89YesNo096
125B:B:D247 B:B:S245 1007.36YesNo099
126R:R:F117 R:R:T152 58.41735.19YesNo056
127R:R:F113 R:R:F117 53.76313.22YesYes375
128R:R:F112 R:R:F113 50.18063.22YesYes377
129R:R:F247 R:R:H289 28.974510.18YesYes089
130R:R:H289 R:R:N293 15.542214.03YesYes399
131R:R:I119 R:R:Y244 26.41073.63YesYes389
132R:R:F112 R:R:F79 36.72914.29YesYes377
133R:R:F79 R:R:Y108 36.298814.44YesNo077
134R:R:F109 R:R:Y108 26.97045.16NoNo057
135R:R:F109 R:R:N163 23.3410.87NoNo2554
136R:R:N163 R:R:S180 22.82324.47NoNo044
137R:R:M210 R:R:Y244 14.51947.18NoYes089
138R:R:F182 R:R:S180 20.74932.64YesNo054
139R:R:F182 R:R:Y187 15.56386.19YesNo053
140R:R:K191 R:R:Y187 14.52652.39NoNo043
141R:R:K191 R:R:T259 14.00793NoYes045
142R:R:N258 R:R:T259 10.3775.85NoYes045
143R:R:F247 R:R:V243 14.48755.24YesNo086
144R:R:T239 R:R:V243 10.34831.59NoNo056
145A:A:S16 B:B:K89 13.00533.06NoYes179
146B:B:S316 B:B:T274 15.85663.2NoYes298
147B:B:D247 B:B:S227 1005.89YesNo096
148A:A:F215 B:B:W99 24.81718.04YesYes299
149B:B:F253 B:B:H225 18.24234.53YesYes569
150B:B:F222 B:B:F253 11.180312.86YesYes586
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7F1R
Class A
SubFamily Protein
Type Chemokine
SubType CCR5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2021-07-14
D.O.I. 10.1038/s41467-021-24438-5
Net Summary
Imin 2.77
Number of Linked Nodes 800
Number of Links 1013
Number of Hubs 183
Number of Links mediated by Hubs 647
Number of Communities 25
Number of Nodes involved in Communities 282
Number of Links involved in Communities 430
Path Summary
Number Of Nodes in MetaPath 151
Number Of Links MetaPath 150
Number of Shortest Paths 29886048
Length Of Smallest Path 3
Average Path Length 70.8555
Length of Longest Path 82
Minimum Path Strength 1.265
Average Path Strength 8.00322
Maximum Path Strength 22.8
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 35.4194
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 65.0441
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • virus receptor activity   • exogenous protein binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • cytoskeletal protein binding   • actin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • chemokine (C-C motif) ligand 5 binding   • identical protein binding   • CCR5 chemokine receptor binding   • CCR chemokine receptor binding   • signaling receptor binding   • cytokine receptor binding   • G protein-coupled receptor binding   • chemokine receptor binding   • protein tyrosine kinase activator activity   • enzyme regulator activity   • receptor signaling protein tyrosine kinase activator activity   • catalytic activity, acting on a protein   • molecular function activator activity   • kinase activity   • protein kinase activity   • transferase activity   • protein kinase regulator activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • kinase activator activity   • enzyme activator activity   • protein tyrosine kinase activity   • molecular function regulator activity   • protein kinase activator activity   • kinase regulator activity   • signaling receptor activator activity   • chemokine activity   • cytokine activity   • signaling receptor regulator activity   • receptor ligand activity   • CCR4 chemokine receptor binding   • CCR1 chemokine receptor binding   • protein homodimerization activity   • protein dimerization activity   • chemoattractant activity   • phospholipase activator activity   • lipase activator activity   • signaling receptor inhibitor activity   • receptor antagonist activity   • molecular function inhibitor activity   • chemokine receptor antagonist activity   • regulation of cellular process   • leukocyte apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • macrophage apoptotic process   • negative regulation of leukocyte apoptotic process   • negative regulation of cellular process   • myeloid cell apoptotic process   • regulation of leukocyte apoptotic process   • regulation of biological process   • negative regulation of programmed cell death   • regulation of apoptotic process   • biological regulation   • negative regulation of macrophage apoptotic process
Gene OntologyBiological Process• regulation of cellular process   • leukocyte apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • macrophage apoptotic process   • negative regulation of leukocyte apoptotic process   • negative regulation of cellular process   • myeloid cell apoptotic process   • regulation of leukocyte apoptotic process   • regulation of biological process   • negative regulation of programmed cell death   • regulation of apoptotic process   • biological regulation   • negative regulation of macrophage apoptotic process   • cell death   • negative regulation of apoptotic process   • regulation of macrophage apoptotic process   • inflammatory cell apoptotic process   • cellular process   • negative regulation of myeloid cell apoptotic process   • apoptotic process   • regulation of myeloid cell apoptotic process   • programmed cell death   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • response to stimulus   • immune response   • immune system process   • response to sterol   • response to lipid   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to cholesterol   • signaling   • cell-cell signaling   • cell communication   • cellular response to stimulus   • biological process involved in interspecies interaction between organisms   • response to other organism   • cellular response to lipopolysaccharide   • response to external stimulus   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • cellular response to oxygen-containing compound   • response to biotic stimulus   • cellular response to biotic stimulus   • cellular response to chemical stimulus   • response to bacterium   • cellular response to lipid   • response to external biotic stimulus   • response to molecule of bacterial origin   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • signal transduction   • MAPK cascade   • chemotaxis   • taxis   • locomotion   • cell chemotaxis   • dendritic cell chemotaxis   • leukocyte migration   • dendritic cell migration   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • cell surface receptor signaling pathway   • defense response   • response to stress   • cellular defense response   • localization   • transport   • monoatomic ion transport   • monoatomic cation transport   • establishment of localization   • calcium ion transport   • metal ion transport   • inflammatory response   • G protein-coupled receptor signaling pathway   • regulation of localization   • cellular localization   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • monoatomic ion transmembrane transport   • sarcoplasmic reticulum calcium ion transport   • calcium ion homeostasis   • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • negative regulation of sequestering of calcium ion   • maintenance of location in cell   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • regulation of sequestering of calcium ion   • intracellular monoatomic ion homeostasis   • release of sequestered calcium ion into cytosol by endoplasmic reticulum   • calcium ion transmembrane import into cytosol   • sequestering of calcium ion   • inorganic ion transmembrane transport   • inorganic cation transmembrane transport   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • cellular homeostasis   • chemical homeostasis   • calcium ion transmembrane transport   • positive regulation of cell communication   • regulation of signaling   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • positive regulation of G protein-coupled receptor signaling pathway   • positive regulation of response to stimulus   • regulation of response to stimulus   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cellular process   • positive regulation of signaling   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of chemotaxis   • positive regulation of cell migration   • regulation of lymphocyte chemotaxis   • natural killer cell chemotaxis   • positive regulation of natural killer cell chemotaxis   • regulation of immune system process   • regulation of mononuclear cell migration   • positive regulation of immune system process   • regulation of leukocyte chemotaxis   • positive regulation of lymphocyte migration   • regulation of leukocyte migration   • lymphocyte migration   • positive regulation of leukocyte chemotaxis   • regulation of locomotion   • regulation of natural killer cell chemotaxis   • regulation of response to external stimulus   • lymphocyte chemotaxis   • regulation of lymphocyte migration   • positive regulation of lymphocyte chemotaxis   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • positive regulation of mononuclear cell migration   • positive regulation of leukocyte migration   • regulation of chemotaxis   • cell surface receptor signaling pathway via STAT   • regulation of intracellular signal transduction   • positive regulation of TOR signaling   • TOR signaling   • regulation of TOR signaling   • positive regulation of intracellular signal transduction   • response to toxic substance   • positive regulation of smooth muscle cell migration   • regulation of smooth muscle cell migration   • smooth muscle cell migration   • muscle cell migration   • response to fibroblast growth factor   • cellular response to endogenous stimulus   • cellular response to growth factor stimulus   • response to endogenous stimulus   • response to growth factor   • cellular response to fibroblast growth factor stimulus   • macrophage migration   • positive regulation of macrophage migration   • granulocyte migration   • macrophage chemotaxis   • regulation of granulocyte chemotaxis   • regulation of macrophage migration   • myeloid leukocyte migration   • regulation of macrophage chemotaxis   • granulocyte chemotaxis   • positive regulation of macrophage chemotaxis   • protein localization   • establishment of protein localization   • nitrogen compound transport   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • multicellular organismal process   • regulation of leukocyte activation   • cell activation   • regulation of cell activation   • regulation of T cell activation   • lymphocyte activation   • leukocyte activation   • T cell activation   • regulation of multicellular organismal process   • regulation of lymphocyte activation   • positive regulation of monocyte chemotaxis   • regulation of monocyte chemotaxis   • monocyte chemotaxis   • positive regulation of viral genome replication   • positive regulation of viral process   • viral life cycle   • regulation of viral life cycle   • regulation of viral process   • viral genome replication   • viral process   • regulation of viral genome replication   • regulation of calcium ion transport   • positive regulation of calcium ion transport   • regulation of monoatomic ion transport   • positive regulation of transport   • positive regulation of monoatomic ion transport   • regulation of metal ion transport   • positive regulation of T cell migration   • regulation of T cell migration   • T cell migration   • cell population proliferation   • regulation of smooth muscle cell proliferation   • positive regulation of cell population proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • cell adhesion   • cell-cell adhesion   • leukocyte cell-cell adhesion   • eosinophil chemotaxis   • eosinophil migration   • regulation of homotypic cell-cell adhesion   • positive regulation of cell adhesion   • regulation of cell adhesion   • homotypic cell-cell adhesion   • positive regulation of cell-cell adhesion   • positive regulation of homotypic cell-cell adhesion   • regulation of cell-cell adhesion   • regulation of lymphocyte apoptotic process   • negative regulation of T cell apoptotic process   • lymphocyte apoptotic process   • regulation of T cell apoptotic process   • T cell apoptotic process   • negative regulation of lymphocyte apoptotic process   • positive regulation of protein metabolic process   • positive regulation of translation   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • post-transcriptional regulation of gene expression   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • translational initiation   • protein metabolic process   • regulation of biosynthetic process   • regulation of translational initiation   • regulation of protein metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • gene expression   • translation   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • regulation of translation   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of translational initiation   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of programmed cell death   • positive regulation of lymphocyte apoptotic process   • positive regulation of apoptotic process   • positive regulation of T cell apoptotic process   • positive regulation of leukocyte apoptotic process   • positive regulation of cell activation   • lymphocyte proliferation   • positive regulation of leukocyte activation   • regulation of leukocyte proliferation   • positive regulation of T cell activation   • positive regulation of lymphocyte proliferation   • positive regulation of T cell proliferation   • mononuclear cell proliferation   • regulation of leukocyte cell-cell adhesion   • positive regulation of leukocyte proliferation   • positive regulation of multicellular organismal process   • positive regulation of leukocyte cell-cell adhesion   • leukocyte proliferation   • positive regulation of lymphocyte activation   • positive regulation of mononuclear cell proliferation   • T cell proliferation   • regulation of lymphocyte proliferation   • regulation of T cell proliferation   • regulation of mononuclear cell proliferation   • response to peptide   • cellular response to interleukin-1   • response to cytokine   • cellular response to cytokine stimulus   • response to interleukin-1   • viral gene expression   • negative regulation by host of viral transcription   • modulation of process of another organism   • viral transcription   • host-mediated perturbation of symbiont process   • positive regulation of receptor signaling pathway via STAT   • regulation of receptor signaling pathway via STAT   • cell-cell adhesion mediated by integrin   • positive regulation of cell adhesion mediated by integrin   • regulation of cell adhesion mediated by integrin   • regulation of cell-cell adhesion mediated by integrin   • positive regulation of cell-cell adhesion mediated by integrin   • cell adhesion mediated by integrin   • neutrophil activation   • myeloid leukocyte activation   • granulocyte activation   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • positive regulation of epithelial cell proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • regulation of defense response   • regulation of chronic inflammatory response   • chronic inflammatory response   • regulation of inflammatory response   • regulation of response to stress   • cellular response to tumor necrosis factor   • response to tumor necrosis factor   • response to type II interferon   • defense response to symbiont   • cellular response to type II interferon   • defense response to other organism   • innate immune response   • humoral immune response   • antimicrobial humoral response   • antimicrobial humoral immune response mediated by antimicrobial peptide   • negative regulation of viral genome replication   • negative regulation of viral process   • response to virus   • positive regulation of T cell chemotaxis   • regulation of T cell chemotaxis   • T cell chemotaxis   • regulation of phospholipase activity   • positive regulation of phospholipase activity   • regulation of catalytic activity   • activation of phospholipase D activity   • positive regulation of catalytic activity   • positive regulation of lipase activity   • regulation of molecular function   • positive regulation of molecular function   • positive regulation of hydrolase activity   • regulation of hydrolase activity   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • exocytosis   • vesicle-mediated transport   • positive regulation of response to biotic stimulus   • regulation of response to biotic stimulus   • positive regulation of immune response   • positive regulation of innate immune response   • regulation of innate immune response   • positive regulation of defense response   • regulation of immune response   • cellular response to virus   • chemokine (C-C motif) ligand 5 signaling pathway   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • endosome   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • endosome   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • vesicle   • extracellular region   • extracellular space   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• G protein-coupled receptor-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7F1R_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMKITGIV ETHFTFKDL HFKMFDVTA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHAS MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7F1R_Chain_B
ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA KIYAMHWGT 
DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM TCAYAPSGN 
YVACGGLDN ICSIYNLKT VRVSRELAG HTGYLSCCR FLDDNQIVT 
SSGDTTCAL WDIETGQQT TTFTGHTGD VMSLSLAPD TRLFVSGAC 
DASAKLWDV REGMCRQTF TGHESDINA ICFFPNGNA FATGSDDAT 
CRLFDLRAD QELMTYSHD NIICGITSV SFSKSGRLL LAGYDDFNC 
NVWDALKAD RAGVLAGHD NRVSCLGVT DDGMAVATG SWDSFLKIW 
N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7F1R_Chain_G
RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51681
Sequence
>7F1R_Chain_R
LPPLYSLVF IFGFVGNML VILILINCK RLKSMTDIY LLNLAISDL 
FFLLTVPFW AHYAAAGNT MCQLLTGLY FIGFFSGIF FIILLTIDR 
YLAVVHAVF ALKARTVTF GVVTSVITW VVAVFASLP NIIFTRSQK 
CGLHYTCSS HFPYSQYQF WKNFQTLKI VILGLVLPL LVMVICYSG 
ILKTLLRCR NEKKRHRAV RLIFTIMIV YFLFWAPYN IVLLLNTFQ 
EFFGLNNCS SSNRLDQAM QVTETLGMT HCCINPIIY AFVGEKFRN 
YLLVFFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F1TAProteinChemokineCCR5Homo sapiensMIP-1a--2.62021-07-1410.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ22.82021-07-1410.1038/s41467-021-24438-5
7F1S (No Gprot) AProteinChemokineCCR5Homo sapiens--2.82021-07-1410.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ232021-07-1410.1038/s41467-021-24438-5
7F1R (No Gprot) AProteinChemokineCCR5Homo sapiens--32021-07-1410.1038/s41467-021-24438-5
7F1QAProteinChemokineCCR5Homo sapiensMIP-1a-Gi1/β1/γ22.92021-07-1410.1038/s41467-021-24438-5
7F1Q (No Gprot) AProteinChemokineCCR5Homo sapiensMIP-1a-2.92021-07-1410.1038/s41467-021-24438-5
7O7FAProteinChemokineCCR5Homo sapiens6P4-CCL5-Gi1/β1/γ13.152021-06-3010.1126/sciadv.abg8685
7O7F (No Gprot) AProteinChemokineCCR5Homo sapiens6P4-CCL5-3.152021-06-3010.1126/sciadv.abg8685
6METAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--4.52018-12-1210.1038/s41586-018-0804-9
6MEOAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--3.92018-12-1210.1038/s41586-018-0804-9
6AKYAProteinChemokineCCR5Homo sapiens-Maraviroc-2.82018-10-2410.1021/acs.jmedchem.8b01077
6AKXAProteinChemokineCCR5Homo sapiens-A4R-2.82018-10-2410.1021/acs.jmedchem.8b01077
5UIWAProteinChemokineCCR5Homo sapiens5P7-CCL5--2.22017-06-2810.1016/j.immuni.2017.05.002
4MBSAProteinChemokineCCR5Homo sapiens-Maraviroc-2.712013-09-1110.1126/science.1241475




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7F1R.zip



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