Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 4.32419
2A:A:D20 5.5825416
3A:A:R32 5.5375404
4A:A:V34 5.66475
5A:A:K35 3.84429
6A:A:L38 4.92754208
7A:A:L39 3.725409
8A:A:K46 7.7045209
9A:A:Q52 4.165479
10A:A:K54 6.0925477
11A:A:E186 8.2175429
12A:A:F191 8.8125475
13A:A:H195 9.375424
14A:A:F196 6.27833677
15A:A:K197 5.55167626
16A:A:M198 3.4525407
17A:A:F199 9.38525
18A:A:Q204 4.984529
19A:A:K209 5.3075428
20A:A:K210 6.884529
21A:A:W211 4.61333629
22A:A:H213 7.6125428
23A:A:C214 5.445427
24A:A:F215 10.56429
25A:A:I221 6.19488
26A:A:I222 6.4975407
27A:A:S228 4.15409
28A:A:D229 6.13754218
29A:A:Y230 7.8675498
30A:A:H244 2.86494
31A:A:M247 5.0725496
32A:A:D251 6.7925485
33A:A:C254 3.9975485
34A:A:W258 7.59167625
35A:A:T262 3.7025487
36A:A:I264 3.2225486
37A:A:I265 4.0925108
38A:A:L266 5.31489
39A:A:F267 4.625109
40A:A:F274 7.646509
41A:A:K277 7.4275499
42A:A:S281 4.7825497
43A:A:C286 5.9175496
44A:A:Y287 8.13714797
45A:A:Y290 6.4425407
46A:A:Y296 7.842504
47A:A:Y320 6.788577107
48A:A:F334 9.25254103
49A:A:F336 6.808578
50A:A:I343 4.738577
51A:A:L348 8.42254199
52A:A:K349 6.224225
53A:A:L353 5.33254197
54G:G:Y40 11.2254126
55G:G:D48 7.238519
56G:G:L50 4.558519
57G:G:L51 3.886516
58G:G:N59 8.5325419
59G:G:F61 6.99818
60R:R:N48 5.4675439
61R:R:L55 4.49754177
62R:R:K59 7.45754175
63R:R:L61 3.51254176
64R:R:M64 6.85754136
65R:R:Y68 6.8265137
66R:R:S75 4.01254158
67R:R:D76 5.67539
68R:R:F79 8.138537
69R:R:Y89 6.546676164
70R:R:F112 5.818537
71R:R:F113 4.00143737
72R:R:I116 5.435437
73R:R:F117 3.734535
74R:R:F118 7.415157
75R:R:I119 5.4525438
76R:R:I120 4.668537
77R:R:T123 3.97439
78R:R:D125 8.13754138
79R:R:Y127 7.00754148
80R:R:V131 8.24147
81R:R:H132 5.984146
82R:R:T148 5.4654136
83R:R:W153 8.95254159
84R:R:F182 5.045405
85R:R:W190 7.2025403
86R:R:P206 5.23539
87R:R:V209 3.855436
88R:R:K229 6.7406
89R:R:Y244 7.32667639
90R:R:F247 6.078508
91R:R:W248 8.5639
92R:R:Y251 7.675407
93R:R:T259 6.3925405
94R:R:M279 3.2254265
95R:R:M287 6.5225438
96R:R:H289 11.925439
97R:R:N293 6.744539
98R:R:Y297 6.294539
99R:R:F304 6.2775408
100B:B:L30 4.3925405
101B:B:V40 3.536513
102B:B:M45 3.77514
103B:B:H54 7.28619
104B:B:K57 8.3775429
105B:B:Y59 8.33714728
106B:B:M61 4.3625416
107B:B:W63 6.83617
108B:B:L70 5.4825415
109B:B:V71 3.74408
110B:B:Q75 7.1875429
111B:B:L79 3.984187
112B:B:I80 7.1975418
113B:B:I81 3.625617
114B:B:W82 7.34857719
115B:B:D83 7.8225418
116B:B:N88 4.33517
117B:B:K89 6.31167619
118B:B:I93 6.1175407
119B:B:L95 4.91754188
120B:B:W99 12.268529
121B:B:M101 3.9125429
122B:B:Y105 4.792506
123B:B:Y111 7.975454
124B:B:C114 4.18754188
125B:B:L117 5.295429
126B:B:I120 4.71406
127B:B:Y124 8.0025186
128B:B:H142 8.35333659
129B:B:Y145 5.48625828
130B:B:L146 3.25333657
131B:B:C148 3.64466
132B:B:C149 3.752558
133B:B:F151 6.29559
134B:B:L152 4.04603
135B:B:T159 4.655659
136B:B:S160 4.42466
137B:B:D163 6.675459
138B:B:C166 3.3925468
139B:B:W169 9.44333658
140B:B:T173 4.3875405
141B:B:T177 6.1925404
142B:B:F180 8.26167667
143B:B:H183 9.09833669
144B:B:D186 6.82429
145B:B:M188 4.94528
146B:B:L190 4.5375465
147B:B:V200 7.8425446
148B:B:D205 5.9875469
149B:B:K209 9.96833666
150B:B:L210 5.354545
151B:B:W211 8.80571768
152B:B:D212 7.2775409
153B:B:Q220 9.26547
154B:B:F222 10.8825448
155B:B:H225 10.3117649
156B:B:D228 6.81667629
157B:B:N230 7.8625429
158B:B:I232 4.078548
159B:B:F234 5.445445
160B:B:F235 7.566676126
161B:B:N237 7.2265125
162B:B:F241 7.235646
163B:B:D246 6.7525429
164B:B:D247 5.0825409
165B:B:F253 6.91833646
166B:B:D258 13.805447
167B:B:Q259 4.446546
168B:B:M262 6.46754114
169B:B:Y264 5.9645115
170B:B:H266 5.25254114
171B:B:T274 4.7775428
172B:B:F278 4.455717127
173B:B:R283 5.435619
174B:B:L284 5.0675415
175B:B:L286 4.31417
176B:B:Y289 7.006676117
177B:B:D290 8.31426
178B:B:N295 8.4254116
179B:B:V296 4.375415
180B:B:W297 7.4225118
181B:B:D298 4.5925419
182B:B:L300 6.172516
183B:B:K301 6.03405
184B:B:H311 10.7075419
185B:B:R314 9.576528
186B:B:L318 5.85416
187B:B:T321 7.0825417
188B:B:V327 4.5825416
189B:B:W332 8.7325829
190B:B:F335 10.3425404
191B:B:L336 5.996517
192B:B:K337 10.7925416
193B:B:I338 4.4075415
194B:B:W339 8.67667619
195B:B:N340 8.63519
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:S16 B:B:N88 13.62892.98NoYes177
2B:B:H54 B:B:S74 22.67439.76YesNo099
3B:B:A56 B:B:S74 22.73393.42NoNo079
4B:B:A56 B:B:D76 22.81831.54NoNo079
5A:A:A30 B:B:D76 23.10511.54NoNo039
6A:A:A30 A:A:K35 23.25631.61NoYes039
7A:A:K35 A:A:V218 15.80253.04YesNo099
8A:A:T262 A:A:V218 15.75814.76YesNo079
9A:A:I221 A:A:T262 16.03393.04YesYes887
10A:A:I221 A:A:I264 72.25232.94YesYes886
11A:A:I264 A:A:K317 85.91052.91YesNo867
12A:A:K317 A:A:R313 1006.19NoNo074
13A:A:R313 A:A:T316 99.67372.59NoNo043
14A:A:D315 A:A:T316 99.51035.78NoNo033
15A:A:D315 R:R:K228 99.34666.91NoNo035
16R:R:K228 R:R:K229 99.18282.87NoYes056
17A:A:F354 R:R:K229 98.19558.69NoYes056
18A:A:F354 A:A:L348 97.367118.27NoYes059
19A:A:L348 A:A:L353 95.98569.69YesYes1997
20A:A:L353 R:R:R126 95.30187.29YesNo079
21R:R:R126 R:R:Y297 94.9634.12NoYes099
22R:R:I119 R:R:Y297 47.47029.67YesYes389
23R:R:I119 R:R:L72 15.54572.85YesNo089
24R:R:F118 R:R:L72 15.78976.09YesNo079
25B:B:H54 B:B:W82 12.34828.46YesYes199
26B:B:D83 B:B:N88 12.61355.39YesYes187
27B:B:D83 B:B:V90 14.91914.38YesNo185
28B:B:I81 B:B:V90 13.98763.07YesNo175
29B:B:I81 B:B:V71 10.12313.07YesYes078
30A:A:F215 A:A:L37 81.006615.83YesNo099
31A:A:L37 A:A:L39 24.70592.77NoYes099
32A:A:F223 A:A:L39 26.89483.65NoYes099
33A:A:F223 A:A:L266 26.27273.65NoYes899
34A:A:F307 A:A:L266 54.1869.74NoYes089
35A:A:F307 A:A:M247 32.38663.73NoYes086
36A:A:H244 A:A:M247 40.76123.94YesYes946
37A:A:C286 A:A:H244 39.93422.95YesYes964
38A:A:C286 A:A:Y230 79.34865.38YesYes968
39A:A:K277 A:A:Y230 87.441917.91YesYes998
40A:A:K277 A:A:S228 85.46693.06YesYes099
41A:A:D229 A:A:S228 81.31074.42YesYes089
42A:A:D229 A:A:S44 77.85034.42YesNo2189
43A:A:G45 A:A:S44 77.18231.86NoNo099
44A:A:G45 A:A:K46 76.49173.49NoYes099
45A:A:K46 A:A:L38 73.01952.82YesYes2098
46A:A:L38 A:A:M198 39.37692.83YesYes087
47A:A:L36 A:A:M198 13.39484.24NoYes077
48A:A:F196 A:A:L36 25.36253.65YesNo077
49A:A:F250 A:A:I264 29.07633.77NoYes896
50A:A:F250 A:A:L266 28.64564.87NoYes899
51A:A:M247 A:A:Y287 41.63618.38YesYes967
52A:A:C286 A:A:Y287 39.96612.1YesYes967
53A:A:F307 A:A:I303 21.59773.77NoNo087
54A:A:I303 A:A:L227 21.04674.28NoNo077
55A:A:F274 A:A:L227 19.378120.7YesNo097
56A:A:F274 A:A:Y230 15.85483.09YesYes098
57A:A:I222 A:A:L38 33.0549.99YesYes078
58A:A:I222 A:A:L36 13.45569.99YesNo077
59A:A:F189 A:A:M198 23.96053.73NoYes097
60A:A:F189 A:A:F196 12.710510.72NoYes097
61A:A:F196 A:A:V34 16.90475.24YesYes775
62A:A:I222 A:A:I265 18.40462.94YesYes078
63A:A:I343 A:A:V34 12.66483.07YesYes775
64A:A:F215 A:A:W211 45.50223.01YesYes299
65A:A:R208 A:A:W211 40.11534NoYes099
66A:A:F189 A:A:K54 10.66018.69NoYes097
67A:A:F196 A:A:F336 10.57034.29YesYes778
68A:A:W211 B:B:Y145 84.09393.86YesYes298
69A:A:K210 B:B:Y145 39.1154.78YesYes298
70A:A:K210 B:B:D228 19.49888.3YesYes299
71B:B:M188 B:B:Y145 38.92293.59YesYes288
72B:B:D228 B:B:M188 19.55614.16YesYes298
73A:A:R208 A:A:S252 37.20165.27NoNo097
74A:A:K210 B:B:N230 19.40378.39YesYes299
75B:B:M188 B:B:N230 19.46084.21YesYes289
76B:B:Q75 B:B:W99 29.26476.57YesYes299
77B:B:Q75 B:B:Y59 23.937213.53YesYes298
78B:B:L318 B:B:S275 22.07153YesNo068
79B:B:S275 B:B:T274 22.19314.8NoYes088
80A:A:K248 A:A:S252 37.12884.59NoNo057
81A:A:D251 A:A:K248 37.05772.77YesNo055
82A:A:D251 A:A:L310 50.486312.21YesNo054
83A:A:C254 A:A:N255 14.25783.15YesNo858
84A:A:D251 A:A:N255 14.25049.42YesNo858
85B:B:C148 B:B:R150 10.72772.79YesNo066
86B:B:C148 B:B:S189 56.56745.16YesNo067
87B:B:I232 B:B:S189 56.90753.1YesNo087
88B:B:V327 G:G:L50 11.00174.47YesYes169
89R:R:N293 R:R:Y297 46.98015.81YesYes399
90R:R:H289 R:R:N293 25.409214.03YesYes399
91R:R:I119 R:R:Y244 32.62673.63YesYes389
92R:R:W248 R:R:Y244 22.482212.54YesYes399
93R:R:F79 R:R:W248 39.21673.01YesYes379
94R:R:H289 R:R:W248 22.345215.87YesYes399
95R:R:D76 R:R:N293 21.93395.39YesYes399
96R:R:C290 R:R:D76 19.99526.22NoYes089
97R:R:C290 R:R:F79 19.788613.97NoYes087
98R:R:F79 R:R:Y108 51.799714.44YesNo077
99R:R:T82 R:R:Y108 10.72619.99NoNo077
100R:R:T82 R:R:W86 10.05723.64NoNo077
101R:R:F109 R:R:Y108 40.61525.16NoNo057
102R:R:F109 R:R:N163 35.959910.87NoNo2454
103R:R:N163 R:R:S180 35.33154.47NoNo044
104R:R:F182 R:R:S180 32.68492.64YesNo054
105R:R:F182 R:R:Y187 25.38986.19YesNo053
106R:R:K191 R:R:Y187 24.06082.39NoNo043
107R:R:K191 R:R:T259 23.3963NoYes045
108R:R:N258 R:R:T259 14.06745.85NoYes045
109B:B:S316 B:B:Y59 25.94416.36NoYes298
110B:B:S316 B:B:T274 26.00673.2NoYes298
111B:B:C148 B:B:S160 23.70683.44YesYes666
112B:B:S160 B:B:V187 22.89994.85YesNo069
113B:B:H183 B:B:V187 20.95755.54YesNo099
114B:B:H183 B:B:K209 18.104123.58YesYes696
115B:B:G182 B:B:K209 34.76933.49NoYes066
116B:B:G182 B:B:T181 33.94575.46NoNo062
117B:B:T165 B:B:T181 33.12186.28NoNo072
118B:B:D163 B:B:T165 32.29777.23YesNo097
119B:B:D163 B:B:H142 29.82056.3YesYes599
120B:B:H142 B:B:T159 17.40175.48YesYes599
121B:B:I157 B:B:T159 14.11123.04NoYes579
122B:B:F151 B:B:I157 12.452511.3YesNo597
123B:B:C148 B:B:L190 28.79093.17YesYes665
124B:B:L190 B:B:S201 21.96186.01YesNo659
125B:B:S201 B:B:W211 20.02243.71NoYes698
126B:B:K209 B:B:W211 18.291112.76YesYes668
127B:B:I232 B:B:T243 56.60124.56YesNo488
128B:B:H225 B:B:T243 56.798710.95YesNo498
129B:B:H225 B:B:S245 70.26038.37YesNo099
130B:B:D228 B:B:D246 38.91145.32YesYes299
131B:B:D246 B:B:N230 38.722410.77YesYes299
132B:B:D246 B:B:S227 73.25295.89YesNo096
133B:B:D247 B:B:S245 70.61777.36YesNo099
134B:B:W297 B:B:Y289 10.114910.61YesYes1187
135B:B:C271 B:B:D290 18.14633.11NoYes056
136B:B:C271 B:B:D291 17.62826.22NoNo058
137A:A:S16 B:B:K89 13.63463.06NoYes179
138B:B:L318 B:B:V327 14.52862.98YesYes166
139B:B:D247 B:B:S227 72.87315.89YesNo096
140B:B:D291 B:B:Y289 15.0594.6NoYes087
141A:A:I221 A:A:L37 56.75329.99YesNo089
142A:A:L310 A:A:M247 50.3034.24NoYes046
143A:A:C254 A:A:K317 14.25224.85YesNo857
144A:A:F215 B:B:W99 29.657618.04YesYes299
145B:B:F253 B:B:H225 11.39154.53YesYes469
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7F1R
Class A
SubFamily Protein
Type Chemokine
SubType CCR5
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2021-07-14
D.O.I. 10.1038/s41467-021-24438-5
Net Summary
Imin 2.65
Number of Linked Nodes 807
Number of Links 1040
Number of Hubs 195
Number of Links mediated by Hubs 694
Number of Communities 26
Number of Nodes involved in Communities 300
Number of Links involved in Communities 457
Path Summary
Number Of Nodes in MetaPath 146
Number Of Links MetaPath 145
Number of Shortest Paths 1991722
Length Of Smallest Path 3
Average Path Length 33.2481
Length of Longest Path 65
Minimum Path Strength 1.385
Average Path Strength 6.33687
Maximum Path Strength 20.535
Minimum Path Correlation 0.7
Average Path Correlation 0.981667
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 36.5882
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.511
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7F1R_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMKITGIV ETHFTFKDL HFKMFDVTA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHAS MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7F1R_Chain_G
RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51681
Sequence
>7F1R_Chain_R
LPPLYSLVF IFGFVGNML VILILINCK RLKSMTDIY LLNLAISDL 
FFLLTVPFW AHYAAAGNT MCQLLTGLY FIGFFSGIF FIILLTIDR 
YLAVVHAVF ALKARTVTF GVVTSVITW VVAVFASLP NIIFTRSQK 
CGLHYTCSS HFPYSQYQF WKNFQTLKI VILGLVLPL LVMVICYSG 
ILKTLLRCR NEKKRHRAV RLIFTIMIV YFLFWAPYN IVLLLNTFQ 
EFFGLNNCS SSNRLDQAM QVTETLGMT HCCINPIIY AFVGEKFRN 
YLLVFFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7F1R_Chain_B
ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA KIYAMHWGT 
DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM TCAYAPSGN 
YVACGGLDN ICSIYNLKT VRVSRELAG HTGYLSCCR FLDDNQIVT 
SSGDTTCAL WDIETGQQT TTFTGHTGD VMSLSLAPD TRLFVSGAC 
DASAKLWDV REGMCRQTF TGHESDINA ICFFPNGNA FATGSDDAT 
CRLFDLRAD QELMTYSHD NIICGITSV SFSKSGRLL LAGYDDFNC 
NVWDALKAD RAGVLAGHD NRVSCLGVT DDGMAVATG SWDSFLKIW 
N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4MBSAProteinChemokineCCR5Homo sapiens-Maraviroc-2.712013-09-1110.1126/science.1241475
5UIWAProteinChemokineCCR5Homo sapiens5P7-CCL5--2.22017-06-2810.1016/j.immuni.2017.05.002
6AKXAProteinChemokineCCR5Homo sapiens-A4R-2.82018-10-2410.1021/acs.jmedchem.8b01077
6AKYAProteinChemokineCCR5Homo sapiens-Maraviroc-2.82018-10-2410.1021/acs.jmedchem.8b01077
6MEOAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--3.92018-12-1210.1038/s41586-018-0804-9
6METAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--4.52018-12-1210.1038/s41586-018-0804-9
7F1QAProteinChemokineCCR5Homo sapiensMIP-1a-Gi1/&β;1/&γ;22.92021-07-1410.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/&β;1/&γ;232021-07-1410.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/&β;1/&γ;22.82021-07-1410.1038/s41467-021-24438-5
7F1TAProteinChemokineCCR5Homo sapiensMIP-1a--2.62021-07-1410.1038/s41467-021-24438-5
7O7FAProteinChemokineCCR5Homo sapiens(6P4)CCL5-Gi1/&β;1/&γ;13.152021-06-3010.1126/sciadv.abg8685




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Download 7F1R.zip



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