Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R32 6.36254234
2A:A:V34 6.176575
3A:A:K35 2.8425409
4A:A:L36 5.23477
5A:A:K46 9.87254249
6A:A:I49 4.555407
7A:A:Q52 10.294579
8A:A:F189 8.415479
9A:A:L194 5.955474
10A:A:H195 8.39754124
11A:A:F196 7.658577
12A:A:K197 9.1945126
13A:A:M198 5.54407
14A:A:F199 9.11254125
15A:A:K210 6.734519
16A:A:W211 6.452509
17A:A:F215 8.855409
18A:A:F223 6.844589
19A:A:Y230 5.9525108
20A:A:F250 8.11589
21A:A:C254 3.722585
22A:A:W258 10.9405
23A:A:F259 5.99489
24A:A:L266 4.234589
25A:A:F267 3.8256159
26A:A:N269 6.814159
27A:A:F274 6.1625109
28A:A:Y287 5.507147107
29A:A:Y296 9.86404
30A:A:Y302 8.1554106
31A:A:Q304 3.29405
32A:A:F307 6.514588
33A:A:Y320 8.088336167
34A:A:F323 5.8825404
35A:A:F336 8.746508
36A:A:F354 10.1265195
37B:B:R22 5.0125406
38B:B:D27 6.82408
39B:B:T34 4.53505
40B:B:V40 3.7845253
41B:B:L51 8.235429
42B:B:H54 9.08333629
43B:B:Y59 11.594138
44B:B:W63 7.825407
45B:B:R68 8.474525
46B:B:S72 5.81429
47B:B:K78 9.64228
48B:B:L79 5.435407
49B:B:I81 4.26254187
50B:B:W82 9.4125829
51B:B:Y85 10.08424
52B:B:K89 7.29167629
53B:B:H91 7.99754185
54B:B:I93 8.45407
55B:B:L95 4.8775408
56B:B:W99 9.504509
57B:B:Y105 4.615406
58B:B:N110 8.63754204
59B:B:Y111 5.4285204
60B:B:L117 4.825409
61B:B:I120 4.99754276
62B:B:Y124 8.43506
63B:B:L139 5.8275409
64B:B:H142 7.668559
65B:B:Y145 5.365818
66B:B:L146 4.4275457
67B:B:F151 5.94167609
68B:B:L152 4.566503
69B:B:T159 5.46333659
70B:B:W169 10.105458
71B:B:T177 3.32404
72B:B:F180 7.13333647
73B:B:H183 7.442549
74B:B:M188 6518
75B:B:F199 6.9549
76B:B:C204 4.7275417
77B:B:D205 7.1375409
78B:B:K209 10.11446
79B:B:L210 5.725415
80B:B:W211 8.05571748
81B:B:D212 6.5275419
82B:B:R219 6.432515
83B:B:Q220 6.236517
84B:B:F222 11.2775418
85B:B:H225 10.3857719
86B:B:S227 4.5325416
87B:B:D228 7.764519
88B:B:I229 4.7375417
89B:B:N230 7.8625419
90B:B:I232 3.5775408
91B:B:F234 7.755415
92B:B:F235 7.618336146
93B:B:P236 6.0154147
94B:B:N237 10.06254145
95B:B:F241 7.534516
96B:B:T243 5.86418
97B:B:S245 7.7125419
98B:B:D246 7.0075419
99B:B:D247 11.248519
100B:B:T249 6.8475416
101B:B:R251 12.242518
102B:B:F253 6.61333616
103B:B:T263 6.375411
104B:B:Y264 6.392505
105B:B:F278 5.525147
106B:B:R283 8.3385259
107B:B:L285 4.7475406
108B:B:Y289 7.057147177
109B:B:C294 3.3175405
110B:B:L300 5.0925406
111B:B:H311 6.761676119
112B:B:R314 9.50754138
113B:B:L318 4.0225406
114B:B:W332 13.136139
115B:B:D333 7.20754119
116B:B:L336 5.96427
117B:B:K337 8.0154116
118B:B:W339 11.375119
119B:B:N340 8.794529
120G:G:Y40 10.70754146
121G:G:D48 9.305409
122G:G:N59 6.33429
123G:G:P60 9.345429
124G:G:F61 6.32375828
125R:R:L55 5.2467
126R:R:L61 4.616566
127R:R:M64 5.8925466
128R:R:D66 7.53468
129R:R:I67 3.79467
130R:R:Y68 5.28833667
131R:R:D76 6.56254289
132R:R:Y108 10.18507
133R:R:F109 8.704535
134R:R:F112 6.978537
135R:R:F113 6.212537
136R:R:I116 3.45437
137R:R:F118 8.1756217
138R:R:D125 7.0025468
139R:R:R126 4.994599
140R:R:Y127 7.47754298
141R:R:V131 6.5354297
142R:R:R140 5.1775466
143R:R:W153 8.3454219
144R:R:C178 3.955439
145R:R:F182 11.45305
146R:R:P206 6.2825439
147R:R:Y214 5.78714799
148R:R:I237 6.46498
149R:R:I240 4.118598
150R:R:Y244 5.17286739
151R:R:F247 3.936538
152R:R:W248 7.542539
153R:R:Y251 6.6025407
154R:R:V254 2.38405
155R:R:T259 7.0175405
156R:R:Q261 2.585404
157R:R:H289 5.46539
158R:R:Y297 6.632509
159R:R:F304 4.04408
160R:R:L308 3.24406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L79 B:B:V71 36.27054.47YesNo078
2B:B:I93 B:B:L79 37.68638.56YesYes077
3B:B:I93 B:B:P94 42.81873.39YesNo075
4B:B:K78 B:B:P94 43.06945.02YesNo085
5B:B:D76 B:B:K78 47.4889.68NoYes098
6B:B:D76 B:B:S74 48.206310.31NoNo099
7B:B:H54 B:B:S74 48.68312.55YesNo099
8A:A:F199 B:B:W99 22.265817.04YesYes059
9B:B:Q75 B:B:W99 24.54565.48NoYes099
10B:B:Q75 B:B:Y59 28.266710.15NoYes098
11B:B:W332 B:B:Y59 28.219621.22YesYes1398
12B:B:S316 B:B:W332 61.34114.94NoYes099
13B:B:C317 B:B:S316 61.145.16NoNo079
14B:B:C317 B:B:M61 60.73634.86NoNo076
15B:B:M61 B:B:S72 53.15493.07NoYes069
16A:A:L36 A:A:V34 12.29624.47YesYes775
17A:A:T219 A:A:V34 18.52026.35NoYes075
18A:A:K35 A:A:T219 18.83543YesNo097
19A:A:F199 A:A:K35 19.77753.72YesYes059
20A:A:R208 A:A:W211 10.04198NoYes099
21A:A:F259 A:A:N256 21.05673.62YesNo098
22A:A:N256 A:A:W258 21.306110.17NoYes085
23A:A:H213 A:A:W258 21.778410.58NoYes085
24A:A:H213 B:B:W332 21.90457.41NoYes1389
25A:A:F250 A:A:F307 10.82511.79YesYes898
26A:A:F250 A:A:I264 16.39153.77YesNo896
27A:A:I221 A:A:I264 19.03427.36NoNo886
28A:A:F259 A:A:I221 19.30117.54YesNo898
29A:A:M247 A:A:Y287 13.50427.18NoYes067
30A:A:F307 A:A:M247 14.56159.95YesNo086
31B:B:D246 B:B:G272 32.98385.03YesNo094
32B:B:D290 B:B:G272 33.01215.03NoNo064
33B:B:D290 B:B:R314 59.94858.34NoYes068
34B:B:R314 B:B:W332 84.101620.99YesYes1389
35A:A:K210 B:B:Y145 13.63343.58YesYes198
36A:A:K210 B:B:D228 10.61356.91YesYes199
37R:R:I217 R:R:V130 10.98856.14NoNo088
38R:R:I217 R:R:Y214 11.19613.63NoYes989
39R:R:R126 R:R:Y214 13.62384.12YesYes999
40R:R:R126 R:R:Y297 19.90868.23YesYes099
41R:R:L122 R:R:Y297 92.62245.86NoYes099
42R:R:L122 R:R:Y68 92.72833.52NoYes097
43R:R:I67 R:R:Y68 95.10473.63YesYes677
44R:R:I67 R:R:L61 95.01175.71YesYes676
45R:R:L61 R:R:R60 97.29513.64YesNo065
46B:B:R52 R:R:R60 97.369920.26NoNo075
47B:B:F335 B:B:R52 97.44735.34NoNo047
48B:B:D333 B:B:F335 97.521910.75YesNo094
49B:B:D333 B:B:H311 97.47883.78YesYes1199
50B:B:H311 B:B:T329 97.301610.95YesNo1198
51B:B:C294 B:B:T329 98.17333.38YesNo058
52B:B:C294 B:B:L318 99.50633.17YesYes056
53B:B:L318 B:B:S275 99.87993YesNo068
54B:B:S275 B:B:T274 99.94024.8NoNo088
55B:B:R314 B:B:T274 1003.88YesNo088
56A:A:F223 A:A:L249 11.11113.65YesNo099
57B:B:D246 B:B:S227 22.59982.94YesYes196
58B:B:S227 B:B:S245 15.34024.89YesYes169
59B:B:H225 B:B:S245 12.086712.55YesYes199
60B:B:F253 B:B:H225 18.98323.39YesYes169
61B:B:F222 B:B:F253 10.53818.57YesYes186
62B:B:D247 B:B:S227 14.68747.36YesYes196
63B:B:D247 B:B:H225 12.102113.87YesYes199
64B:B:C271 B:B:D290 40.06246.22NoNo056
65B:B:C271 B:B:Y289 38.56794.03NoYes1757
66B:B:W297 B:B:Y289 35.11416.75NoYes1787
67B:B:W297 B:B:Y264 35.024512.54NoYes085
68B:B:L285 B:B:Y264 18.39954.69YesYes065
69B:B:V112 B:B:V71 34.55024.81NoNo088
70B:B:V112 B:B:Y105 34.15962.52NoYes086
71B:B:H62 B:B:Y105 33.33434.36NoYes066
72B:B:H62 B:B:R150 33.058112.41NoNo066
73B:B:L192 B:B:R150 32.78146.07NoNo056
74B:B:F199 B:B:L192 27.31313.65YesNo095
75B:B:F199 B:B:L190 13.10074.87YesNo495
76B:B:C148 B:B:L190 12.8586.35NoNo065
77B:B:C148 B:B:T102 12.54723.38NoNo068
78B:B:C149 B:B:T102 12.23595.07NoNo088
79B:B:L252 B:B:Y264 10.31923.52NoYes075
80B:B:F235 B:B:F278 15.17844.29YesYes1467
81B:B:F235 B:B:N237 10.759213.29YesYes1465
82R:R:I119 R:R:Y297 46.90528.46NoYes089
83R:R:I119 R:R:Y244 46.71653.63NoYes089
84R:R:I116 R:R:Y244 16.24813.63YesYes379
85R:R:F112 R:R:I116 16.6345.02YesYes377
86R:R:F112 R:R:F79 15.74094.29YesNo077
87R:R:W86 R:R:Y108 10.1478.68NoYes077
88R:R:W248 R:R:Y244 28.42035.79YesYes399
89R:R:F112 R:R:W248 31.998910.02YesYes379
90R:R:N293 R:R:Y297 36.43956.98NoYes099
91R:R:H289 R:R:N293 30.91053.83YesNo099
92R:R:H289 R:R:W248 28.70099.52YesYes399
93R:R:W248 R:R:Y251 24.87696.75YesYes097
94R:R:T282 R:R:Y251 14.85883.75NoYes077
95R:R:F112 R:R:F113 17.874311.79YesYes377
96R:R:F109 R:R:F113 12.63037.5YesYes357
97R:R:F109 R:R:T105 11.54012.59YesNo355
98R:R:F112 R:R:I198 14.37313.77YesNo375
99R:R:I198 R:R:Q194 13.6525.49NoNo055
100R:R:K197 R:R:Q194 12.39284.07NoNo035
101R:R:K197 R:R:P162 10.85131.67NoNo038
102R:R:L161 R:R:P162 10.07984.93NoNo048
103B:B:H54 B:B:S72 46.60549.76YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7F1S
Class A
SubFamily Protein
Type Chemokine
SubType CCR5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.8
Date 2021-07-14
D.O.I. 10.1038/s41467-021-24438-5
Net Summary
Imin 3
Number of Linked Nodes 799
Number of Links 969
Number of Hubs 160
Number of Links mediated by Hubs 588
Number of Communities 31
Number of Nodes involved in Communities 218
Number of Links involved in Communities 307
Path Summary
Number Of Nodes in MetaPath 104
Number Of Links MetaPath 103
Number of Shortest Paths 699578
Length Of Smallest Path 3
Average Path Length 27.0812
Length of Longest Path 63
Minimum Path Strength 1.235
Average Path Strength 6.69097
Maximum Path Strength 21.105
Minimum Path Correlation 0.7
Average Path Correlation 0.972673
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 46.7332
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.3957
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • virus receptor activity   • exogenous protein binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • hydrolase activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • catalytic activity   • phospholipase activity   • lipase activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • cytoskeletal protein binding   • actin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • chemokine (C-C motif) ligand 5 binding   • identical protein binding   • regulation of cellular process   • leukocyte apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • macrophage apoptotic process   • negative regulation of leukocyte apoptotic process   • negative regulation of cellular process   • myeloid cell apoptotic process   • regulation of leukocyte apoptotic process   • regulation of biological process   • negative regulation of programmed cell death   • regulation of apoptotic process   • biological regulation   • negative regulation of macrophage apoptotic process
Gene OntologyBiological Process• regulation of cellular process   • leukocyte apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • macrophage apoptotic process   • negative regulation of leukocyte apoptotic process   • negative regulation of cellular process   • myeloid cell apoptotic process   • regulation of leukocyte apoptotic process   • regulation of biological process   • negative regulation of programmed cell death   • regulation of apoptotic process   • biological regulation   • negative regulation of macrophage apoptotic process   • cell death   • negative regulation of apoptotic process   • regulation of macrophage apoptotic process   • inflammatory cell apoptotic process   • cellular process   • negative regulation of myeloid cell apoptotic process   • apoptotic process   • regulation of myeloid cell apoptotic process   • programmed cell death   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • response to stimulus   • immune response   • immune system process   • response to sterol   • response to lipid   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to cholesterol   • signaling   • cell-cell signaling   • cell communication   • cellular response to stimulus   • biological process involved in interspecies interaction between organisms   • response to other organism   • cellular response to lipopolysaccharide   • response to external stimulus   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • cellular response to oxygen-containing compound   • response to biotic stimulus   • cellular response to biotic stimulus   • cellular response to chemical stimulus   • response to bacterium   • cellular response to lipid   • response to external biotic stimulus   • response to molecule of bacterial origin   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • signal transduction   • MAPK cascade   • chemotaxis   • taxis   • locomotion   • cell chemotaxis   • dendritic cell chemotaxis   • leukocyte migration   • dendritic cell migration   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • cell surface receptor signaling pathway   • defense response   • response to stress   • cellular defense response   • localization   • transport   • monoatomic ion transport   • monoatomic cation transport   • establishment of localization   • calcium ion transport   • metal ion transport   • inflammatory response   • G protein-coupled receptor signaling pathway   • regulation of localization   • cellular localization   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • monoatomic ion transmembrane transport   • sarcoplasmic reticulum calcium ion transport   • calcium ion homeostasis   • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • negative regulation of sequestering of calcium ion   • maintenance of location in cell   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • regulation of sequestering of calcium ion   • intracellular monoatomic ion homeostasis   • release of sequestered calcium ion into cytosol by endoplasmic reticulum   • calcium ion transmembrane import into cytosol   • sequestering of calcium ion   • inorganic ion transmembrane transport   • inorganic cation transmembrane transport   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • cellular homeostasis   • chemical homeostasis   • calcium ion transmembrane transport   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • endosome   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • endosome   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • vesicle   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• G protein-coupled receptor-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7F1S_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMKITGIV ETHFTFKDL HFKMFDVTA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHAS MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7F1S_Chain_B
ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA KIYAMHWGT 
DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM TCAYAPSGN 
YVACGGLDN ICSIYNLKT REGNVRVSR ELAGHTGYL SCCRFLDDN 
QIVTSSGDT TCALWDIET GQQTTTFTG HTGDVMSLS LAPDTRLFV 
SGACDASAK LWDVREGMC RQTFTGHES DINAICFFP NGNAFATGS 
DDATCRLFD LRADQELMT YSHDNIICG ITSVSFSKS GRLLLAGYD 
DFNCNVWDA LKADRAGVL AGHDNRVSC LGVTDDGMA VATGSWDSF 
LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7F1S_Chain_G
RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51681
Sequence
>7F1S_Chain_R
LPPLYSLVF IFGFVGNML VILILINCK RLKSMTDIY LLNLAISDL 
FFLLTVPFW AHYAFGNTM CQLLTGLYF IGFFSGIFF IILLTIDRY 
LAVVHAVFA LKARTVTFG VVTSVITWV VAVFASLPN IIFTRSQKE 
GLHYTCSSH FPYSQYQFW KNFQTLKIV ILGLVLPLL VMVICYSGI 
LKTLLRCRN EKKRHRAVR LIFTIMIVY FLFWAPYNI VLLLNTFQE 
FFGLNNCSS SNRLDQAMQ VTETLGMTH CCINPIIYA FVGEKFRNY 
LLVFFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F1TAProteinChemokineCCR5Homo sapiensMIP-1a--2.62021-07-1410.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ22.82021-07-1410.1038/s41467-021-24438-5
7F1S (No Gprot) AProteinChemokineCCR5Homo sapiens--2.82021-07-1410.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ232021-07-1410.1038/s41467-021-24438-5
7F1R (No Gprot) AProteinChemokineCCR5Homo sapiens--32021-07-1410.1038/s41467-021-24438-5
7F1QAProteinChemokineCCR5Homo sapiensMIP-1a-Gi1/β1/γ22.92021-07-1410.1038/s41467-021-24438-5
7F1Q (No Gprot) AProteinChemokineCCR5Homo sapiensMIP-1a-2.92021-07-1410.1038/s41467-021-24438-5
7O7FAProteinChemokineCCR5Homo sapiens6P4-CCL5-Gi1/β1/γ13.152021-06-3010.1126/sciadv.abg8685
7O7F (No Gprot) AProteinChemokineCCR5Homo sapiens6P4-CCL5-3.152021-06-3010.1126/sciadv.abg8685
6METAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--4.52018-12-1210.1038/s41586-018-0804-9
6MEOAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--3.92018-12-1210.1038/s41586-018-0804-9
6AKYAProteinChemokineCCR5Homo sapiens-Maraviroc-2.82018-10-2410.1021/acs.jmedchem.8b01077
6AKXAProteinChemokineCCR5Homo sapiens-A4R-2.82018-10-2410.1021/acs.jmedchem.8b01077
5UIWAProteinChemokineCCR5Homo sapiens5P7-CCL5--2.22017-06-2810.1016/j.immuni.2017.05.002
4MBSAProteinChemokineCCR5Homo sapiens-Maraviroc-2.712013-09-1110.1126/science.1241475




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