Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R32 7.81754204
2A:A:E33 9.11254156
3A:A:V34 6.176555
4A:A:K35 4.8025409
5A:A:L36 5.23457
6A:A:L38 5.5954178
7A:A:K46 8.8765179
8A:A:I49 4.555407
9A:A:Q52 10.2575459
10A:A:E186 5.794159
11A:A:F189 8.415459
12A:A:F191 10.3475455
13A:A:L194 5.955454
14A:A:H195 5.62754154
15A:A:F196 7.658557
16A:A:K197 9.4645156
17A:A:M198 5.54407
18A:A:F199 9.11254155
19A:A:E207 16.9775419
20A:A:K209 13.3375418
21A:A:K210 12.4619
22A:A:W211 6.452509
23A:A:F215 8.855409
24A:A:E216 7.21254137
25A:A:F223 6.844569
26A:A:D229 6.9575408
27A:A:Y230 5.9525128
28A:A:F250 8.11569
29A:A:C254 3.722565
30A:A:F259 5.99469
31A:A:L266 4.234569
32A:A:F267 3.825679
33A:A:N269 6.81479
34A:A:F274 6.1625129
35A:A:Y287 5.507147127
36A:A:Y296 6.495404
37A:A:Y302 10.44126
38A:A:Q304 3.29405
39A:A:F307 6.514568
40A:A:R313 5.3875464
41A:A:Y320 5.09667677
42A:A:T321 5.76405
43A:A:F323 5.8825404
44A:A:Q333 5.52455
45A:A:F336 7.01558
46A:A:F354 11.7825405
47G:G:Y40 10.70754166
48G:G:D48 8.235189
49G:G:N59 6.33429
50G:G:P60 9.7625429
51G:G:F61 6.32375828
52R:R:F41 5.2125407
53R:R:M64 5.89254106
54R:R:I67 3.794107
55R:R:Y68 5.288336107
56R:R:D76 6.56254239
57R:R:F79 7.6875407
58R:R:Y108 8.98637
59R:R:F109 8.704535
60R:R:F112 6.978537
61R:R:F113 6.212537
62R:R:I116 3.45437
63R:R:F118 8.1756197
64R:R:D125 6.284108
65R:R:R126 4.9945119
66R:R:Y127 7.47754258
67R:R:V131 6.5354257
68R:R:R140 5.17754106
69R:R:T141 5.98254206
70R:R:W153 8.3454199
71R:R:Y176 4.3475404
72R:R:C178 3.955439
73R:R:F182 12.085265
74R:R:W190 13.41754263
75R:R:P206 6.2825439
76R:R:Y214 5.787147119
77R:R:C224 4.84754224
78R:R:I237 6.464118
79R:R:I240 4.1185118
80R:R:Y244 5.17286739
81R:R:F247 3.936538
82R:R:W248 7.542539
83R:R:Y251 5.878537
84R:R:T259 6.64254275
85R:R:F260 3.615405
86R:R:H289 5.46539
87R:R:Y297 6.632509
88R:R:L308 3.24406
89B:B:D27 6.475408
90B:B:S31 3.085401
91B:B:T34 4.5425405
92B:B:V40 4.3454283
93B:B:L51 8.235429
94B:B:H54 9.08333629
95B:B:Y59 11.594138
96B:B:W63 7.825407
97B:B:R68 8.474525
98B:B:S72 5.81429
99B:B:K78 9.2525408
100B:B:L79 5.435407
101B:B:I81 3.998527
102B:B:W82 9.4125829
103B:B:Y85 10.08424
104B:B:K89 7.29167629
105B:B:H91 7.9975425
106B:B:I93 7.348507
107B:B:L95 4.8775408
108B:B:W99 9.504509
109B:B:N110 8.2875444
110B:B:Y111 5.428544
111B:B:L117 4.825409
112B:B:I120 4.99754306
113B:B:I123 3.9675446
114B:B:Y124 8.43506
115B:B:L139 5.8275409
116B:B:H142 7.668549
117B:B:Y145 5.365818
118B:B:F151 5.94167649
119B:B:L152 4.566503
120B:B:T159 5.46333649
121B:B:W169 10.105448
122B:B:F180 7.13333697
123B:B:H183 7.442599
124B:B:M188 5.424518
125B:B:F199 6.9599
126B:B:C204 5.75617
127B:B:D205 7.1375409
128B:B:K209 10.11496
129B:B:L210 5.725415
130B:B:W211 9.16333698
131B:B:D212 7.7975419
132B:B:R219 8.324515
133B:B:Q220 8.846517
134B:B:F222 10.38418
135B:B:H225 10.3857719
136B:B:S227 4.5325416
137B:B:D228 7.85333619
138B:B:I229 5.1225417
139B:B:I232 3.5775408
140B:B:F234 7.755415
141B:B:F235 7.618336166
142B:B:P236 6.0154167
143B:B:F241 7.534516
144B:B:T243 5.86418
145B:B:S245 7.7275419
146B:B:D246 7.0075419
147B:B:D247 11.472519
148B:B:T249 6.8475416
149B:B:R251 11.9467618
150B:B:F253 6.61333616
151B:B:T263 6.375411
152B:B:Y264 6.392505
153B:B:F278 5.525167
154B:B:S279 4.214189
155B:B:R283 8.3385289
156B:B:L285 4.7475406
157B:B:Y289 7.057147147
158B:B:C294 3.3175405
159B:B:N295 7.44146
160B:B:L300 4.7225406
161B:B:H311 6.76167689
162B:B:R314 9.50754138
163B:B:L318 4.0225406
164B:B:W332 11.72147139
165B:B:D333 8.205489
166B:B:L336 5.96427
167B:B:K337 8.015486
168B:B:W339 11.37589
169B:B:N340 8.794529
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:S74 12.161312.55YesNo099
2B:B:D76 B:B:S74 11.724410.31NoNo099
3B:B:D76 B:B:K78 11.28959.68NoYes098
4A:A:F199 A:A:K35 98.17963.72YesYes059
5A:A:F199 B:B:W99 98.330117.04YesYes059
6B:B:Q75 B:B:W99 41.65835.48NoYes099
7B:B:Q75 B:B:Y59 44.006210.15NoYes098
8B:B:W332 B:B:Y59 42.945321.22YesYes1398
9B:B:S316 B:B:W332 27.74484.94NoYes099
10B:B:C317 B:B:S316 27.54275.16NoNo079
11B:B:C317 B:B:M61 27.13774.86NoNo076
12B:B:M61 B:B:S72 18.69013.07NoYes069
13A:A:K35 A:A:T219 98.93863YesNo097
14A:A:T219 A:A:V34 98.97136.35NoYes075
15A:A:L36 A:A:V34 96.89914.47YesYes575
16A:A:L36 A:A:M198 96.69434.24YesYes077
17A:A:F215 B:B:W99 31.854413.03YesYes099
18A:A:F215 A:A:L37 15.537514.61YesNo099
19A:A:L37 A:A:L39 15.28634.15NoNo099
20A:A:L249 A:A:R208 21.27637.29NoNo099
21A:A:F215 A:A:W211 16.35814.01YesYes099
22A:A:R208 A:A:W211 22.24328NoYes099
23A:A:L249 A:A:L39 14.88874.15NoNo099
24A:A:M247 A:A:Y287 12.91467.18NoYes067
25A:A:F307 A:A:M247 14.03999.95YesNo086
26A:A:I49 A:A:M198 97.64027.29YesYes077
27A:A:F267 A:A:I49 99.56613.77YesYes097
28B:B:G162 B:B:Y145 29.35934.35NoYes098
29B:B:L117 B:B:Y145 33.80115.86YesYes098
30B:B:L117 B:B:W99 31.58664.56YesYes099
31B:B:D290 B:B:R314 25.53848.34NoYes068
32B:B:R314 B:B:W332 30.311920.99YesYes1389
33A:A:K210 B:B:D228 17.73729.68YesYes199
34A:A:K210 B:B:Y145 18.72863.58YesYes198
35A:A:A338 A:A:F334 1002.77NoNo763
36A:A:F267 A:A:F334 99.86443.22YesNo793
37A:A:F223 A:A:L249 35.4663.65YesNo099
38A:A:L266 A:A:T321 18.95637.37YesYes095
39A:A:L268 A:A:T321 12.14742.95NoYes085
40A:A:A338 A:A:Y320 99.8215.34NoYes767
41A:A:E318 R:R:N226 47.74276.57NoNo044
42A:A:E318 A:A:Y320 47.73043.37NoYes747
43A:A:D341 A:A:Y320 52.40416.9NoYes087
44A:A:D341 R:R:R223 52.36135.96NoNo085
45A:A:F354 R:R:K229 44.500322.33YesNo056
46R:R:K229 R:R:N226 47.61096.99NoNo064
47A:A:I344 R:R:R223 52.05888.77NoNo065
48A:A:I344 R:R:V130 52.0244.61NoNo068
49A:A:F354 A:A:L348 41.584515.83YesNo059
50A:A:L348 A:A:L353 41.53666.92NoNo097
51A:A:L353 R:R:R126 41.60616.07NoYes079
52R:R:I217 R:R:V130 51.52066.14NoNo088
53R:R:I217 R:R:Y214 51.02333.63NoYes1189
54R:R:R126 R:R:Y214 42.34424.12YesYes1199
55B:B:C271 B:B:D290 27.856.22NoNo056
56B:B:C271 B:B:Y289 26.76764.03NoYes1457
57B:B:W297 B:B:Y289 23.78326.75NoYes1487
58B:B:W297 B:B:Y264 23.674812.54NoYes085
59B:B:L285 B:B:Y264 11.5544.69YesYes065
60R:R:R126 R:R:Y297 83.81098.23YesYes099
61R:R:I119 R:R:Y297 46.6278.46NoYes089
62R:R:I119 R:R:Y244 46.43943.63NoYes089
63R:R:W248 R:R:Y244 29.22545.79YesYes399
64R:R:W248 R:R:Y251 27.47866.75YesYes397
65R:R:Y108 R:R:Y251 13.51572.98YesYes377
66R:R:N293 R:R:Y297 35.8126.98NoYes099
67R:R:H289 R:R:N293 31.3493.83YesNo099
68R:R:H289 R:R:W248 29.32949.52YesYes399
69R:R:I116 R:R:Y244 15.55913.63YesYes379
70R:R:F112 R:R:I116 22.51775.02YesYes377
71R:R:F112 R:R:F79 14.21494.29YesYes077
72R:R:F112 R:R:W248 30.408210.02YesYes379
73R:R:F112 R:R:F113 24.568411.79YesYes377
74R:R:F109 R:R:F113 17.8627.5YesYes357
75R:R:F109 R:R:T105 25.99812.59YesNo355
76R:R:C178 R:R:T105 14.18211.69YesNo395
77R:R:C101 R:R:C178 11.83117.28NoYes099
78R:R:C101 R:R:M100 10.6491.62NoNo096
79R:R:F109 R:R:Y108 10.607411.35YesYes357
80R:R:T105 R:R:T167 10.63656.28NoNo355
81R:R:F112 R:R:I198 13.50973.77YesNo375
82R:R:I198 R:R:Q194 12.77765.49NoNo055
83R:R:K197 R:R:Q194 11.4224.07NoNo035
84B:B:G162 B:B:S161 27.95723.71NoNo099
85B:B:H142 B:B:S161 27.722716.74YesNo099
86B:B:H142 B:B:T159 20.35365.48YesYes499
87B:B:C149 B:B:T159 14.59696.76NoYes489
88B:B:C149 B:B:T102 14.46355.07NoNo088
89B:B:C148 B:B:T102 14.21623.38NoNo068
90B:B:C148 B:B:L190 10.16356.35NoNo065
91B:B:F253 B:B:H225 10.0493.39YesYes169
92B:B:H54 B:B:S72 12.83549.76YesYes299
93A:A:F223 A:A:F307 12.93643.22YesYes698
94A:A:F223 A:A:L266 16.01713.65YesYes699
95B:B:D228 B:B:S227 14.76092.94YesYes196
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7F1S
Class A
SubFamily Protein
Type Chemokine
SubType CCR5
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.8
Date 2021-07-14
D.O.I. 10.1038/s41467-021-24438-5
Net Summary
Imin 2.94
Number of Linked Nodes 809
Number of Links 1004
Number of Hubs 169
Number of Links mediated by Hubs 611
Number of Communities 31
Number of Nodes involved in Communities 250
Number of Links involved in Communities 355
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 1336872
Length Of Smallest Path 3
Average Path Length 30.7943
Length of Longest Path 57
Minimum Path Strength 1.14
Average Path Strength 6.61351
Maximum Path Strength 21.105
Minimum Path Correlation 0.7
Average Path Correlation 0.978949
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 39.8434
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.5822
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7F1S_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKCTIV 
KQMKITGIV ETHFTFKDL HFKMFDVTA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHAS MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7F1S_Chain_G
RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51681
Sequence
>7F1S_Chain_R
LPPLYSLVF IFGFVGNML VILILINCK RLKSMTDIY LLNLAISDL 
FFLLTVPFW AHYAFGNTM CQLLTGLYF IGFFSGIFF IILLTIDRY 
LAVVHAVFA LKARTVTFG VVTSVITWV VAVFASLPN IIFTRSQKE 
GLHYTCSSH FPYSQYQFW KNFQTLKIV ILGLVLPLL VMVICYSGI 
LKTLLRCRN EKKRHRAVR LIFTIMIVY FLFWAPYNI VLLLNTFQE 
FFGLNNCSS SNRLDQAMQ VTETLGMTH CCINPIIYA FVGEKFRNY 
LLVFFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7F1S_Chain_B
ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA KIYAMHWGT 
DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM TCAYAPSGN 
YVACGGLDN ICSIYNLKT REGNVRVSR ELAGHTGYL SCCRFLDDN 
QIVTSSGDT TCALWDIET GQQTTTFTG HTGDVMSLS LAPDTRLFV 
SGACDASAK LWDVREGMC RQTFTGHES DINAICFFP NGNAFATGS 
DDATCRLFD LRADQELMT YSHDNIICG ITSVSFSKS GRLLLAGYD 
DFNCNVWDA LKADRAGVL AGHDNRVSC LGVTDDGMA VATGSWDSF 
LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4MBSAProteinChemokineCCR5Homo sapiens-Maraviroc-2.712013-09-1110.1126/science.1241475
5UIWAProteinChemokineCCR5Homo sapiens5P7-CCL5--2.22017-06-2810.1016/j.immuni.2017.05.002
6AKXAProteinChemokineCCR5Homo sapiens-A4R-2.82018-10-2410.1021/acs.jmedchem.8b01077
6AKYAProteinChemokineCCR5Homo sapiens-Maraviroc-2.82018-10-2410.1021/acs.jmedchem.8b01077
6MEOAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--3.92018-12-1210.1038/s41586-018-0804-9
6METAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--4.52018-12-1210.1038/s41586-018-0804-9
7F1QAProteinChemokineCCR5Homo sapiensMIP-1a-Gi1/&β;1/&γ;22.92021-07-1410.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/&β;1/&γ;232021-07-1410.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/&β;1/&γ;22.82021-07-1410.1038/s41467-021-24438-5
7F1TAProteinChemokineCCR5Homo sapiensMIP-1a--2.62021-07-1410.1038/s41467-021-24438-5
7O7FAProteinChemokineCCR5Homo sapiens(6P4)CCL5-Gi1/&β;1/&γ;13.152021-06-3010.1126/sciadv.abg8685




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7F1S.zip



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