psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P34	R:R:P35	5.84	No	No	0	6	5
2	R:R:L36	R:R:L39	5.54	No	No	0	6	5
3	R:R:V83	R:R:Y37	7.57	No	No	6	7	8
4	R:R:T284	R:R:Y37	6.24	No	No	0	6	8
5	R:R:M287	R:R:Y37	8.38	No	No	6	8	8
6	R:R:T288	R:R:V40	4.76	No	No	0	5	7
7	R:R:F41	R:R:I42	5.02	No	No	0	7	5
8	R:R:F41	R:R:P84	7.22	No	No	0	7	9
9	R:R:C291	R:R:F43	5.59	No	No	0	8	5
10	R:R:C291	R:R:G44	3.92	No	No	0	8	8
11	R:R:F45	R:R:M49	4.98	No	No	0	6	3
12	R:R:F45	R:R:L81	4.87	No	No	0	6	5
13	R:R:A73	R:R:N48	3.13	No	Yes	0	9	9
14	R:R:D76	R:R:N48	6.73	Yes	Yes	1	9	9
15	R:R:L77	R:R:N48	5.49	No	Yes	0	7	9
16	R:R:N48	R:R:P294	6.52	Yes	No	1	9	9
17	R:R:L77	R:R:M49	2.83	No	No	0	7	3
18	R:R:L308	R:R:L50	9.69	No	No	0	6	6
19	R:R:L69	R:R:V51	2.98	No	No	0	8	8
20	R:R:A73	R:R:I52	3.25	No	No	0	9	7
21	R:R:F304	R:R:I54	7.54	Yes	No	0	8	7
22	R:R:I54	R:R:L308	4.28	No	No	0	7	6
23	R:R:K59	R:R:L55	5.64	Yes	Yes	5	5	7
24	R:R:L55	R:R:L61	2.77	Yes	Yes	5	7	6
25	R:R:D66	R:R:L55	10.86	No	Yes	5	8	7
26	R:R:L55	R:R:L70	4.15	Yes	No	5	7	6
27	R:R:I56	R:R:L61	2.85	No	Yes	0	3	6
28	R:R:C58	R:R:N57	6.3	No	No	0	5	4
29	R:R:F311	R:R:N57	12.08	No	No	0	4	4
30	R:R:C58	R:R:Y307	8.06	No	No	0	5	5
31	R:R:D66	R:R:K59	13.83	No	Yes	5	8	5
32	R:R:F304	R:R:K59	4.96	Yes	Yes	0	8	5
33	R:R:K59	R:R:Y307	9.55	Yes	No	0	5	5
34	R:R:K62	R:R:R60	4.95	No	No	0	7	5
35	R:R:I67	R:R:L61	4.28	No	Yes	0	7	6
36	R:R:L61	R:R:L70	4.15	Yes	No	5	6	6
37	R:R:D66	R:R:S63	10.31	No	No	0	8	7
38	R:R:M64	R:R:Y68	5.99	Yes	Yes	2	6	7
39	R:R:D125	R:R:M64	5.54	Yes	Yes	2	8	6
40	R:R:M64	R:R:R140	12.41	Yes	No	2	6	6
41	R:R:G145	R:R:M64	3.49	No	Yes	2	7	6
42	R:R:D125	R:R:T65	5.78	Yes	No	0	8	8
43	R:R:L121	R:R:Y68	10.55	No	Yes	2	6	7
44	R:R:D125	R:R:Y68	5.75	Yes	Yes	2	8	7
45	R:R:G145	R:R:Y68	4.35	No	Yes	2	7	7
46	R:R:T148	R:R:Y68	7.49	Yes	Yes	2	6	7
47	R:R:I74	R:R:L70	2.85	No	No	0	6	6
48	R:R:F118	R:R:N71	14.5	Yes	No	3	7	9
49	R:R:N71	R:R:S149	2.98	No	No	3	9	7
50	R:R:N71	R:R:W153	12.43	No	Yes	3	9	9
51	R:R:D76	R:R:L72	6.79	Yes	No	0	9	9
52	R:R:F118	R:R:L72	6.09	Yes	No	0	7	9
53	R:R:I119	R:R:L72	2.85	Yes	No	0	8	9
54	R:R:S114	R:R:S75	6.52	Yes	Yes	3	7	8
55	R:R:G115	R:R:S75	3.71	No	Yes	0	9	8
56	R:R:F118	R:R:S75	3.96	Yes	Yes	3	7	8
57	R:R:C290	R:R:D76	6.22	No	Yes	0	8	9
58	R:R:D76	R:R:N293	5.39	Yes	Yes	1	9	9
59	R:R:D76	R:R:P294	3.22	Yes	No	1	9	9
60	R:R:F78	R:R:L107	13.4	No	No	0	7	5
61	R:R:F78	R:R:W153	5.01	No	Yes	0	7	9
62	R:R:F79	R:R:Y108	14.44	Yes	No	0	7	7
63	R:R:F112	R:R:F79	4.29	Yes	Yes	1	7	7
64	R:R:F79	R:R:W248	3.01	Yes	Yes	1	7	9
65	R:R:C290	R:R:F79	13.97	No	Yes	0	8	7
66	R:R:L80	R:R:M287	7.07	No	No	0	6	8
67	R:R:T82	R:R:W86	3.64	No	No	0	7	7
68	R:R:T82	R:R:Y108	9.99	No	No	0	7	7
69	R:R:P84	R:R:V83	5.3	No	No	0	9	7
70	R:R:M287	R:R:V83	4.56	No	No	6	8	7
71	R:R:F85	R:R:L104	4.87	No	No	0	6	5
72	R:R:L104	R:R:W86	3.42	No	No	0	5	7
73	R:R:C178	R:R:W86	5.22	No	No	0	9	7
74	R:R:M100	R:R:Y89	3.59	No	Yes	0	6	4
75	R:R:C101	R:R:Y89	6.72	No	Yes	7	9	4
76	R:R:S169	R:R:Y89	3.82	No	Yes	0	4	4
77	R:R:Y176	R:R:Y89	13.9	No	Yes	0	4	4
78	R:R:C178	R:R:Y89	2.69	No	Yes	7	9	4
79	R:R:N98	R:R:R168	7.23	No	No	0	3	4
80	R:R:N98	R:R:S169	5.96	No	No	0	3	4
81	R:R:Q102	R:R:T99	2.83	No	No	0	7	3
82	R:R:C101	R:R:C178	7.28	No	No	7	9	9
83	R:R:Q102	R:R:T167	2.83	No	No	0	7	5
84	R:R:F109	R:R:T105	3.89	Yes	No	8	5	5
85	R:R:N163	R:R:T105	4.39	No	No	8	4	5
86	R:R:G106	R:R:I164	3.53	No	No	0	5	4
87	R:R:I110	R:R:L107	2.85	No	No	0	5	5
88	R:R:F109	R:R:Y108	5.16	Yes	No	0	5	7
89	R:R:F109	R:R:S160	2.64	Yes	No	0	5	7
90	R:R:F109	R:R:N163	10.87	Yes	No	8	5	4
91	R:R:I110	R:R:S160	4.64	No	No	0	5	7
92	R:R:F112	R:R:F113	3.22	Yes	Yes	1	7	7
93	R:R:F112	R:R:I116	8.79	Yes	Yes	1	7	7
94	R:R:F112	R:R:I198	3.77	Yes	No	1	7	5
95	R:R:F112	R:R:W248	9.02	Yes	Yes	1	7	9
96	R:R:F113	R:R:F117	3.22	Yes	Yes	1	7	5
97	R:R:A159	R:R:F113	2.77	No	Yes	0	5	7
98	R:R:F113	R:R:S160	3.96	Yes	No	0	7	7
99	R:R:F113	R:R:K197	6.2	Yes	No	0	7	3
100	R:R:F113	R:R:I198	3.77	Yes	No	1	7	5
101	R:R:F113	R:R:L201	4.87	Yes	No	1	7	4
102	R:R:F118	R:R:S114	2.64	Yes	Yes	3	7	7
103	R:R:S114	R:R:W153	12.36	Yes	Yes	3	7	9
104	R:R:I116	R:R:P206	3.39	Yes	Yes	1	7	9
105	R:R:I116	R:R:Y244	6.04	Yes	Yes	1	7	9
106	R:R:I116	R:R:W248	3.52	Yes	Yes	1	7	9
107	R:R:F117	R:R:T152	5.19	Yes	No	0	5	6
108	R:R:A156	R:R:F117	2.77	No	Yes	0	7	5
109	R:R:F117	R:R:L201	4.87	Yes	No	1	5	4
110	R:R:F118	R:R:S149	2.64	Yes	No	3	7	7
111	R:R:F118	R:R:T152	6.49	Yes	No	0	7	6
112	R:R:F118	R:R:W153	6.01	Yes	Yes	3	7	9
113	R:R:I119	R:R:Y244	3.63	Yes	Yes	1	8	9
114	R:R:I119	R:R:N293	5.66	Yes	Yes	1	8	9
115	R:R:I119	R:R:Y297	9.67	Yes	Yes	1	8	9
116	R:R:I120	R:R:T123	3.04	Yes	Yes	1	7	9
117	R:R:I120	R:R:I124	2.94	Yes	No	1	7	7
118	R:R:I120	R:R:L205	4.28	Yes	No	1	7	6
119	R:R:I120	R:R:P206	8.47	Yes	Yes	1	7	9
120	R:R:I120	R:R:V209	4.61	Yes	Yes	1	7	6
121	R:R:L121	R:R:T148	2.95	No	Yes	2	6	6
122	R:R:L121	R:R:T152	2.95	No	No	0	6	6
123	R:R:L122	R:R:Y297	7.03	No	Yes	0	9	9
124	R:R:T123	R:R:V209	4.76	Yes	Yes	1	9	6
125	R:R:M210	R:R:T123	3.01	No	Yes	0	8	9
126	R:R:C213	R:R:T123	5.07	No	Yes	0	8	9
127	R:R:I124	R:R:V209	3.07	No	Yes	1	7	6
128	R:R:D125	R:R:R140	15.48	Yes	No	2	8	6
129	R:R:R126	R:R:Y297	4.12	No	Yes	0	9	9
130	R:R:V131	R:R:Y127	15.14	Yes	Yes	4	7	8
131	R:R:H132	R:R:Y127	3.27	Yes	Yes	4	6	8
132	R:R:C213	R:R:Y127	6.72	No	Yes	0	8	8
133	R:R:G216	R:R:Y127	2.9	No	Yes	0	4	8
134	R:R:H132	R:R:L128	6.43	Yes	No	4	6	5
135	R:R:F135	R:R:L128	7.31	No	No	4	5	5
136	R:R:V130	R:R:V131	3.21	No	Yes	4	8	7
137	R:R:I217	R:R:V130	10.75	No	No	0	8	8
138	R:R:T220	R:R:V130	4.76	No	No	4	5	8
139	R:R:H132	R:R:V131	9.69	Yes	Yes	4	6	7
140	R:R:T220	R:R:V131	4.76	No	Yes	4	5	7
141	R:R:F135	R:R:H132	4.53	No	Yes	4	5	6
142	R:R:A139	R:R:F135	5.55	No	No	0	4	5
143	R:R:A136	R:R:R140	2.77	No	No	0	5	6
144	R:R:T141	R:R:T143	3.14	No	No	0	6	4
145	R:R:F144	R:R:T141	3.89	No	No	0	3	6
146	R:R:F144	R:R:T148	7.78	No	Yes	0	3	6
147	R:R:G145	R:R:T148	3.64	No	Yes	2	7	6
148	R:R:L161	R:R:V157	4.47	No	No	0	4	4
149	R:R:I164	R:R:L161	4.28	No	No	0	4	4
150	R:R:N163	R:R:S180	4.47	No	No	0	4	4
151	R:R:F166	R:R:I165	3.77	No	No	0	5	3
152	R:R:F166	R:R:P183	23.12	No	No	0	5	3
153	R:R:F166	R:R:W190	6.01	No	Yes	0	5	3
154	R:R:Q170	R:R:R168	5.84	No	No	0	1	4
155	R:R:K171	R:R:S169	3.06	No	No	0	2	4
156	R:R:F182	R:R:S180	2.64	Yes	No	0	5	4
157	R:R:F182	R:R:P183	4.33	Yes	No	0	5	3
158	R:R:F182	R:R:Y187	6.19	Yes	No	0	5	3
159	R:R:F182	R:R:W190	7.02	Yes	Yes	0	5	3
160	R:R:P183	R:R:S185	3.56	No	No	0	3	3
161	R:R:Y184	R:R:Y187	11.91	No	No	0	1	3
162	R:R:Q186	R:R:S185	8.66	No	No	0	3	3
163	R:R:Q186	R:R:W190	8.76	No	Yes	0	3	3
164	R:R:F189	R:R:N192	3.62	No	No	0	1	3
165	R:R:F193	R:R:W190	7.02	No	Yes	0	3	3
166	R:R:K191	R:R:T259	3	No	Yes	0	4	5
167	R:R:L196	R:R:N192	4.12	No	No	0	4	3
168	R:R:K197	R:R:Q194	6.78	No	No	0	3	5
169	R:R:I198	R:R:Q194	2.74	No	No	0	5	5
170	R:R:T195	R:R:T259	14.13	No	Yes	0	5	5
171	R:R:N252	R:R:V199	7.39	No	No	0	8	5
172	R:R:L256	R:R:V199	8.94	No	No	0	5	5
173	R:R:I200	R:R:L201	2.85	No	No	0	5	4
174	R:R:I200	R:R:V204	4.61	No	No	0	5	4
175	R:R:G202	R:R:P206	4.06	No	Yes	0	6	9
176	R:R:L203	R:R:L207	2.77	No	No	0	8	6
177	R:R:A249	R:R:L203	4.73	No	No	0	6	8
178	R:R:L203	R:R:N252	10.98	No	No	0	8	8
179	R:R:L205	R:R:P206	3.28	No	Yes	1	6	9
180	R:R:L205	R:R:V209	2.98	No	Yes	1	6	6
181	R:R:P206	R:R:Y244	6.95	Yes	Yes	1	9	9
182	R:R:I212	R:R:L208	2.85	No	No	0	4	4
183	R:R:M210	R:R:Y214	4.79	No	No	0	8	9
184	R:R:M210	R:R:Y244	7.18	No	Yes	0	8	9
185	R:R:I237	R:R:Y214	19.34	No	No	0	8	9
186	R:R:M241	R:R:Y214	9.58	No	No	0	8	9
187	R:R:K219	R:R:S215	3.06	No	No	0	3	3
188	R:R:G216	R:R:K219	5.23	No	No	0	4	3
189	R:R:I217	R:R:I237	2.94	No	No	0	8	8
190	R:R:L218	R:R:V234	4.47	No	No	0	4	6
191	R:R:C224	R:R:L221	4.76	No	No	0	4	8
192	R:R:C224	R:R:R230	2.79	No	No	0	4	7
193	R:R:K229	R:R:N226	11.19	No	No	0	6	4
194	R:R:K228	R:R:K229	2.87	No	No	0	5	6
195	R:R:R232	R:R:R235	3.2	No	No	0	7	5
196	R:R:R232	R:R:R305	5.33	No	No	0	7	8
197	R:R:I240	R:R:L236	5.71	No	No	0	8	8
198	R:R:L236	R:R:V300	8.94	No	No	0	8	7
199	R:R:F238	R:R:M241	3.73	No	No	0	5	8
200	R:R:I240	R:R:I296	4.42	No	No	0	8	8
201	R:R:F247	R:R:V243	5.24	Yes	No	0	8	6
202	R:R:W248	R:R:Y244	12.54	Yes	Yes	1	9	9
203	R:R:H289	R:R:Y244	7.62	Yes	Yes	1	9	9
204	R:R:A249	R:R:F245	8.32	No	No	0	6	5
205	R:R:F247	R:R:L285	7.31	Yes	No	0	8	8
206	R:R:F247	R:R:T288	3.89	Yes	No	0	8	5
207	R:R:F247	R:R:H289	10.18	Yes	Yes	0	8	9
208	R:R:F247	R:R:I292	3.77	Yes	No	0	8	6
209	R:R:G286	R:R:W248	7.04	No	Yes	0	8	9
210	R:R:H289	R:R:W248	15.87	Yes	Yes	1	9	9
211	R:R:N252	R:R:Y251	4.65	No	Yes	0	8	7
212	R:R:L255	R:R:Y251	14.07	No	Yes	0	6	7
213	R:R:T282	R:R:Y251	7.49	No	Yes	0	7	7
214	R:R:E283	R:R:Y251	4.49	No	Yes	0	6	7
215	R:R:I253	R:R:L257	2.85	No	No	0	6	4
216	R:R:A278	R:R:V254	3.39	No	No	0	6	5
217	R:R:M279	R:R:V254	4.56	Yes	No	0	5	5
218	R:R:L255	R:R:N258	2.75	No	No	9	6	4
219	R:R:L255	R:R:M279	2.83	No	Yes	9	6	5
220	R:R:F263	R:R:L257	4.87	No	No	0	1	4
221	R:R:N258	R:R:T259	5.85	No	Yes	0	4	5
222	R:R:M279	R:R:N258	2.8	Yes	No	9	5	4
223	R:R:G265	R:R:Q261	3.29	No	No	0	4	4
224	R:R:E262	R:R:F263	15.16	No	No	0	3	1
225	R:R:F264	R:R:N267	8.46	No	No	0	1	3
226	R:R:N267	R:R:S270	5.96	No	No	0	3	1
227	R:R:N267	R:R:S271	8.94	No	No	0	3	1
228	R:R:N273	R:R:R274	3.62	No	No	0	1	2
229	R:R:Q277	R:R:Q280	12.8	No	No	0	1	3
230	R:R:Q277	R:R:V281	4.3	No	No	0	1	5
231	R:R:E283	R:R:M279	2.71	No	Yes	0	6	5
232	R:R:H289	R:R:N293	14.03	Yes	Yes	1	9	9
233	R:R:I296	R:R:N293	2.83	No	Yes	1	8	9
234	R:R:N293	R:R:Y297	5.81	Yes	Yes	1	9	9
235	R:R:F299	R:R:I295	6.28	No	No	0	7	6
236	R:R:I296	R:R:Y297	4.84	No	Yes	1	8	9
237	R:R:A298	R:R:F304	8.32	No	Yes	0	7	8
238	R:R:F299	R:R:F304	4.29	No	Yes	0	7	8
239	R:R:F299	R:R:V51	2.62	No	No	0	7	8
240	R:R:F117	R:R:V155	2.62	Yes	No	0	5	4
241	R:R:F238	R:R:V234	2.62	No	No	0	5	6
242	R:R:F260	R:R:T259	2.59	No	Yes	0	5	5
243	R:R:F43	R:R:I295	2.51	No	No	0	5	6
244	R:R:F78	R:R:I74	2.51	No	No	0	7	6
245	R:R:F41	R:R:L81	2.44	No	No	0	7	5
246	R:R:K191	R:R:Y187	2.39	No	No	0	4	3
247	R:R:H181	R:R:R168	2.26	No	No	0	4	4
248	R:R:A249	R:R:P250	1.87	No	No	0	6	9
249	R:R:G111	R:R:S75	1.86	No	Yes	3	8	8
250	R:R:G111	R:R:S114	1.86	No	Yes	3	8	7
251	R:R:G47	R:R:V46	1.84	No	No	0	8	3
252	R:R:G106	R:R:T105	1.82	No	No	0	5	5
253	R:R:A129	R:R:A136	1.79	No	No	0	8	5
254	R:R:G97	R:R:M100	1.75	No	No	0	8	6
255	R:R:C269	R:R:S270	1.72	No	No	0	6	1
256	R:R:L33	R:R:P34	1.64	No	No	0	6	6
257	R:R:L161	R:R:P162	1.64	No	No	0	4	8
258	R:R:A139	R:R:K138	1.61	No	No	0	4	3
259	R:R:V142	R:R:V146	1.6	No	No	0	2	4
260	R:R:V146	R:R:V150	1.6	No	No	0	4	4
261	R:R:V150	R:R:V154	1.6	No	No	0	4	4
262	R:R:S180	R:R:T167	1.6	No	No	0	4	5
263	R:R:S179	R:R:T177	1.6	No	No	0	3	2
264	R:R:T143	R:R:V147	1.59	No	No	0	4	1
265	R:R:T239	R:R:V243	1.59	No	No	0	5	6
266	R:R:A233	R:R:L221	1.58	No	No	0	8	8
267	R:R:C224	R:R:N226	1.57	No	No	0	4	4
268	R:R:I42	R:R:S38	1.55	No	No	0	5	3
269	R:R:I67	R:R:V146	1.54	No	No	0	7	4
270	R:R:I151	R:R:V147	1.54	No	No	0	3	1
271	R:R:I212	R:R:V211	1.54	No	No	0	4	4
272	R:R:I242	R:R:V243	1.54	No	No	0	5	6
273	R:R:M241	R:R:V211	1.52	No	No	0	8	4
274	R:R:L39	R:R:V40	1.49	No	No	0	5	7
275	R:R:L275	R:R:V254	1.49	No	No	0	5	5
276	R:R:N306	R:R:V310	1.48	No	No	0	5	4
277	R:R:I52	R:R:L53	1.43	No	No	0	7	4
278	R:R:I200	R:R:L196	1.43	No	No	0	5	4
279	R:R:L103	R:R:M100	1.41	No	No	0	5	6
280	R:R:H231	R:R:V234	1.38	No	No	0	5	6
281	R:R:H175	R:R:T177	1.37	No	No	0	1	2
282	R:R:L275	R:R:Q261	1.33	No	No	0	5	4
283	R:R:D276	R:R:Q280	1.31	No	No	0	4	3
284	R:R:R235	R:R:T239	1.29	No	No	0	5	5
285	R:R:K229	R:R:R232	1.24	No	No	0	6	7
286	R:R:F245	R:R:L246	1.22	No	No	0	5	5
287	R:R:L222	R:R:R230	1.21	No	No	0	4	7
288	R:R:E262	R:R:F260	1.17	No	No	0	3	5
289	R:R:E302	R:R:R305	1.16	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N48	5.4675	4	1	9
2	R:R:L55	5.855	4	5	7
3	R:R:K59	8.495	4	5	5
4	R:R:L61	3.5125	4	5	6
5	R:R:M64	6.8575	4	2	6
6	R:R:Y68	6.826	5	2	7
7	R:R:S75	4.0125	4	3	8
8	R:R:D76	5.67	5	1	9
9	R:R:F79	8.9275	4	1	7
10	R:R:Y89	6.144	5	7	4
11	R:R:F109	5.64	4	8	5
12	R:R:F112	5.818	5	1	7
13	R:R:F113	4.00143	7	1	7
14	R:R:S114	5.845	4	3	7
15	R:R:I116	5.435	4	1	7
16	R:R:F117	3.734	5	1	5
17	R:R:F118	6.04714	7	3	7
18	R:R:I119	5.4525	4	1	8
19	R:R:I120	4.668	5	1	7
20	R:R:T123	3.97	4	1	9
21	R:R:D125	8.1375	4	2	8
22	R:R:Y127	7.0075	4	4	8
23	R:R:V131	8.2	4	4	7
24	R:R:H132	5.98	4	4	6
25	R:R:T148	5.465	4	2	6
26	R:R:W153	8.9525	4	3	9
27	R:R:F182	5.045	4	0	5
28	R:R:W190	7.2025	4	0	3
29	R:R:P206	5.23	5	1	9
30	R:R:V209	3.855	4	1	6
31	R:R:Y244	7.32667	6	1	9
32	R:R:F247	6.078	5	0	8
33	R:R:W248	8.5	6	1	9
34	R:R:Y251	7.675	4	0	7
35	R:R:T259	6.3925	4	0	5
36	R:R:M279	3.225	4	9	5
37	R:R:H289	11.925	4	1	9
38	R:R:N293	6.744	5	1	9
39	R:R:Y297	6.294	5	1	9
40	R:R:F304	6.2775	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T288	R:R:V40	11.1241	4.76	No	No	0	5	7
2	R:R:F247	R:R:T288	14.7964	3.89	Yes	No	0	8	5
3	R:R:F247	R:R:H289	77.2927	10.18	Yes	Yes	0	8	9
4	R:R:H289	R:R:N293	49.2919	14.03	Yes	Yes	1	9	9
5	R:R:D76	R:R:N293	42.3381	5.39	Yes	Yes	1	9	9
6	R:R:D76	R:R:N48	51.6261	6.73	Yes	Yes	1	9	9
7	R:R:L77	R:R:N48	40.1113	5.49	No	Yes	0	7	9
8	R:R:L77	R:R:M49	37.1423	2.83	No	No	0	7	3
9	R:R:F45	R:R:M49	34.1537	4.98	No	No	0	6	3
10	R:R:F45	R:R:L81	31.1456	4.87	No	No	0	6	5
11	R:R:F41	R:R:L81	28.118	2.44	No	No	0	7	5
12	R:R:F41	R:R:P84	18.9081	7.22	No	No	0	7	9
13	R:R:P84	R:R:V83	15.8023	5.3	No	No	0	9	7
14	R:R:F299	R:R:I295	11.8566	6.28	No	No	0	7	6
15	R:R:F299	R:R:F304	20.5782	4.29	No	Yes	0	7	8
16	R:R:F304	R:R:K59	34.5444	4.96	Yes	Yes	0	8	5
17	R:R:K59	R:R:L55	47.739	5.64	Yes	Yes	5	5	7
18	R:R:L55	R:R:L70	54.4877	4.15	Yes	No	5	7	6
19	R:R:I74	R:R:L70	76.277	2.85	No	No	0	6	6
20	R:R:F78	R:R:I74	78.7382	2.51	No	No	0	7	6
21	R:R:F78	R:R:W153	58.2967	5.01	No	Yes	0	7	9
22	R:R:F118	R:R:W153	55.8746	6.01	Yes	Yes	3	7	9
23	R:R:F118	R:R:L72	89.1689	6.09	Yes	No	0	7	9
24	R:R:D76	R:R:L72	40.0332	6.79	Yes	No	0	9	9
25	R:R:I119	R:R:L72	64.7036	2.85	Yes	No	0	8	9
26	R:R:I119	R:R:N293	25.6568	5.66	Yes	Yes	1	8	9
27	R:R:I119	R:R:Y244	58.3065	3.63	Yes	Yes	1	8	9
28	R:R:H289	R:R:Y244	30.6182	7.62	Yes	Yes	1	9	9
29	R:R:L61	R:R:L70	19.2695	4.15	Yes	No	5	6	6
30	R:R:K59	R:R:Y307	11.7004	9.55	Yes	No	0	5	5
31	R:R:I67	R:R:L61	14.8354	4.28	No	Yes	0	7	6
32	R:R:F118	R:R:T152	46.5866	6.49	Yes	No	0	7	6
33	R:R:L121	R:R:T152	60.0352	2.95	No	No	0	6	6
34	R:R:L121	R:R:Y68	34.7495	10.55	No	Yes	2	6	7
35	R:R:M64	R:R:Y68	12.9993	5.99	Yes	Yes	2	6	7
36	R:R:H289	R:R:W248	32.5227	15.87	Yes	Yes	1	9	9
37	R:R:F112	R:R:W248	16.5055	9.02	Yes	Yes	1	7	9
38	R:R:F112	R:R:F113	37.6013	3.22	Yes	Yes	1	7	7
39	R:R:F113	R:R:F117	36.3219	3.22	Yes	Yes	1	7	5
40	R:R:F117	R:R:T152	37.9627	5.19	Yes	No	0	5	6
41	R:R:D125	R:R:Y68	15.9977	5.75	Yes	Yes	2	8	7
42	R:R:L121	R:R:T148	22.2776	2.95	No	Yes	2	6	6
43	R:R:C290	R:R:D76	25.9498	6.22	No	Yes	0	8	9
44	R:R:C290	R:R:F79	26.4967	13.97	No	Yes	0	8	7
45	R:R:F79	R:R:W248	56.5094	3.01	Yes	Yes	1	7	9
46	R:R:I110	R:R:L107	30.6085	2.85	No	No	0	5	5
47	R:R:I110	R:R:S160	32.5715	4.64	No	No	0	5	7
48	R:R:F113	R:R:S160	41.4298	3.96	Yes	No	0	7	7
49	R:R:F79	R:R:Y108	88.9638	14.44	Yes	No	0	7	7
50	R:R:T82	R:R:Y108	45.8248	9.99	No	No	0	7	7
51	R:R:T82	R:R:W86	43.1976	3.64	No	No	0	7	7
52	R:R:C178	R:R:W86	35.7652	5.22	No	No	0	9	7
53	R:R:C178	R:R:Y89	30.5108	2.69	No	Yes	7	9	4
54	R:R:S169	R:R:Y89	17.1306	3.82	No	Yes	0	4	4
55	R:R:N98	R:R:S169	11.5148	5.96	No	No	0	3	4
56	R:R:F109	R:R:Y108	81.3947	5.16	Yes	No	0	5	7
57	R:R:F109	R:R:N163	99.0819	10.87	Yes	No	8	5	4
58	R:R:N163	R:R:S180	100	4.47	No	No	0	4	4
59	R:R:F109	R:R:T105	13.3216	3.89	Yes	No	8	5	5
60	R:R:G106	R:R:T105	13.3704	1.82	No	No	0	5	5
61	R:R:G106	R:R:I164	10.7335	3.53	No	No	0	5	4
62	R:R:F113	R:R:L201	15.6363	4.87	Yes	No	1	7	4
63	R:R:P206	R:R:Y244	16.1442	6.95	Yes	Yes	1	9	9
64	R:R:I120	R:R:P206	16.1246	8.47	Yes	Yes	1	7	9
65	R:R:M210	R:R:Y244	73.806	7.18	No	Yes	0	8	9
66	R:R:M210	R:R:T123	38.4999	3.01	No	Yes	0	8	9
67	R:R:C213	R:R:T123	36.1266	5.07	No	Yes	0	8	9
68	R:R:C213	R:R:Y127	33.2259	6.72	No	Yes	0	8	8
69	R:R:H132	R:R:Y127	15.3238	3.27	Yes	Yes	4	6	8
70	R:R:M210	R:R:Y214	36.3317	4.79	No	No	0	8	9
71	R:R:I237	R:R:Y214	11.5246	19.34	No	No	0	8	9
72	R:R:A136	R:R:R140	13.2142	2.77	No	No	0	5	6
73	R:R:F144	R:R:T148	16.6911	7.78	No	Yes	0	3	6
74	R:R:F144	R:R:T141	13.39	3.89	No	No	0	3	6
75	R:R:T141	R:R:T143	10.0693	3.14	No	No	0	6	4
76	R:R:F182	R:R:P183	10.5577	4.33	Yes	No	0	5	3
77	R:R:F182	R:R:S180	92.3821	2.64	Yes	No	0	5	4
78	R:R:F182	R:R:W190	12.9407	7.02	Yes	Yes	0	5	3
79	R:R:F182	R:R:Y187	72.2141	6.19	Yes	No	0	5	3
80	R:R:I200	R:R:L196	10.4209	1.43	No	No	0	5	4
81	R:R:I200	R:R:L201	17.2771	2.85	No	No	0	5	4
82	R:R:K191	R:R:Y187	67.8973	2.39	No	No	0	4	3
83	R:R:K191	R:R:T259	65.6802	3	No	Yes	0	4	5
84	R:R:N258	R:R:T259	50.0537	5.85	No	Yes	0	4	5
85	R:R:L255	R:R:N258	30.462	2.75	No	No	9	6	4
86	R:R:L255	R:R:Y251	28.6844	14.07	No	Yes	0	6	7
87	R:R:N252	R:R:Y251	24.2504	4.65	No	Yes	0	8	7
88	R:R:L203	R:R:N252	16.3395	10.98	No	No	0	8	8
89	R:R:A249	R:R:L203	10.9679	4.73	No	No	0	6	8
90	R:R:M241	R:R:Y214	23.6351	9.58	No	No	0	8	9
91	R:R:F238	R:R:M241	11.9641	3.73	No	No	0	5	8
92	R:R:C224	R:R:N226	18.4491	1.57	No	No	0	4	4
93	R:R:K229	R:R:N226	22.0822	11.19	No	No	0	6	4
94	R:R:K229	R:R:R232	29.29	1.24	No	No	0	6	7
95	R:R:R232	R:R:R235	39.6914	3.2	No	No	0	7	5
96	R:R:R235	R:R:T239	43.2073	1.29	No	No	0	5	5
97	R:R:T239	R:R:V243	46.7038	1.59	No	No	0	5	6
98	R:R:F247	R:R:V243	53.6381	5.24	Yes	No	0	8	6
99	R:R:I240	R:R:I296	14.7378	4.42	No	No	0	8	8
100	R:R:I296	R:R:N293	15.7047	2.83	No	Yes	1	8	9
101	R:R:I240	R:R:L236	10.0596	5.71	No	No	0	8	8
102	R:R:M279	R:R:N258	17.2282	2.8	Yes	No	9	5	4
103	R:R:E262	R:R:F260	10.7335	1.17	No	No	0	3	5
104	R:R:F260	R:R:T259	13.3704	2.59	No	Yes	0	5	5
105	R:R:M279	R:R:V254	13.5951	4.56	Yes	No	0	5	5
106	R:R:I67	R:R:V146	11.9055	1.54	No	No	0	7	4
107	R:R:F78	R:R:L107	29.9639	13.4	No	No	0	7	5
108	R:R:F112	R:R:F79	15.7242	4.29	Yes	Yes	1	7	7
109	R:R:F109	R:R:S160	57.0857	2.64	Yes	No	0	5	7
110	R:R:F112	R:R:I116	20.7247	8.79	Yes	Yes	1	7	7
111	R:R:W248	R:R:Y244	34.6616	12.54	Yes	Yes	1	9	9
112	R:R:I116	R:R:P206	18.3709	3.39	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7F1R_nogp

PDB Summary
PDB	7F1R_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	253
Number of Links	289
Number of Hubs	40
Number of Links mediated by Hubs	139
Number of Communities	9
Number of Nodes involved in Communities	61
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	113
Number Of Links MetaPath	112
Number of Shortest Paths	38723
Length Of Smallest Path	3
Average Path Length	12.9322
Length of Longest Path	29
Minimum Path Strength	1.44
Average Path Strength	5.63865
Maximum Path Strength	14.95
Minimum Path Correlation	0.7
Average Path Correlation	0.923972
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	51.8143
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.066
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • CCR5 chemokine receptor binding • CCR chemokine receptor binding • cytokine receptor binding • chemokine receptor binding • protein tyrosine kinase activator activity • kinase activator activity • enzyme activator activity • receptor signaling protein tyrosine kinase activator activity • molecular function activator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • catalytic activity, acting on a protein • kinase activity • protein kinase activity • transferase activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • identical protein binding • signaling receptor activator activity • chemokine activity • cytokine activity • signaling receptor regulator activity • receptor ligand activity • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • phospholipase activity • lipase activity • CCR4 chemokine receptor binding • CCR1 chemokine receptor binding • protein homodimerization activity • protein dimerization activity • chemoattractant activity • phospholipase activator activity • lipase activator activity • signaling receptor inhibitor activity • chemokine receptor antagonist activity • receptor antagonist activity • virus receptor activity • exogenous protein binding • molecular transducer activity • coreceptor activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • cytoskeletal protein binding • actin binding • C-C chemokine binding • chemokine binding • cytokine binding • chemokine (C-C motif) ligand 5 binding • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of response to stimulus • regulation of response to stimulus • regulation of G protein-coupled receptor signaling pathway • positive regulation of signaling • phospholipase D-activating G protein-coupled receptor signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of lymphocyte chemotaxis • natural killer cell chemotaxis • taxis • positive regulation of natural killer cell chemotaxis • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • positive regulation of lymphocyte migration • regulation of leukocyte migration • response to external stimulus • positive regulation of leukocyte chemotaxis • regulation of locomotion • regulation of natural killer cell chemotaxis • regulation of response to external stimulus • lymphocyte chemotaxis • regulation of lymphocyte migration • positive regulation of lymphocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of mononuclear cell migration • locomotion • cell chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • leukocyte chemotaxis • cell surface receptor signaling pathway via STAT • cell surface receptor signaling pathway • regulation of intracellular signal transduction • positive regulation of TOR signaling • TOR signaling • regulation of TOR signaling • positive regulation of intracellular signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • response to toxic substance • positive regulation of smooth muscle cell migration • regulation of smooth muscle cell migration • smooth muscle cell migration • muscle cell migration • response to fibroblast growth factor • cellular response to growth factor stimulus • response to growth factor • cellular response to fibroblast growth factor stimulus • macrophage migration • positive regulation of macrophage migration • granulocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • myeloid leukocyte migration • regulation of macrophage chemotaxis • granulocyte chemotaxis • positive regulation of macrophage chemotaxis • dendritic cell chemotaxis • dendritic cell migration • regulation of leukocyte activation • cell activation • regulation of cell activation • regulation of T cell activation • lymphocyte activation • leukocyte activation • T cell activation • regulation of multicellular organismal process • regulation of lymphocyte activation • positive regulation of monocyte chemotaxis • regulation of monocyte chemotaxis • monocyte chemotaxis • positive regulation of viral genome replication • positive regulation of viral process • viral life cycle • regulation of viral life cycle • regulation of viral process • viral genome replication • viral process • regulation of viral genome replication • regulation of calcium ion transport • positive regulation of calcium ion transport • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of T cell migration • regulation of T cell migration • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • cell adhesion • cell-cell adhesion • leukocyte cell-cell adhesion • eosinophil chemotaxis • eosinophil migration • regulation of homotypic cell-cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • homotypic cell-cell adhesion • positive regulation of cell-cell adhesion • positive regulation of homotypic cell-cell adhesion • regulation of cell-cell adhesion • regulation of leukocyte apoptotic process • regulation of lymphocyte apoptotic process • negative regulation of programmed cell death • leukocyte apoptotic process • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of T cell apoptotic process • lymphocyte apoptotic process • negative regulation of apoptotic process • negative regulation of leukocyte apoptotic process • regulation of T cell apoptotic process • T cell apoptotic process • apoptotic process • programmed cell death • negative regulation of lymphocyte apoptotic process • positive regulation of protein metabolic process • positive regulation of translation • protein biosynthetic process • positive regulation of macromolecule biosynthetic process • post-transcriptional regulation of gene expression • positive regulation of macromolecule metabolic process • translational initiation • protein metabolic process • regulation of translational initiation • regulation of protein metabolic process • regulation of macromolecule metabolic process • gene expression • translation • macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of translation • regulation of macromolecule biosynthetic process • positive regulation of translational initiation • macromolecule metabolic process • positive regulation of programmed cell death • positive regulation of lymphocyte apoptotic process • positive regulation of apoptotic process • positive regulation of T cell apoptotic process • positive regulation of leukocyte apoptotic process • positive regulation of cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • regulation of leukocyte proliferation • positive regulation of T cell activation • positive regulation of lymphocyte proliferation • positive regulation of T cell proliferation • mononuclear cell proliferation • regulation of leukocyte cell-cell adhesion • positive regulation of leukocyte proliferation • positive regulation of multicellular organismal process • positive regulation of leukocyte cell-cell adhesion • leukocyte proliferation • positive regulation of lymphocyte activation • positive regulation of mononuclear cell proliferation • T cell proliferation • regulation of lymphocyte proliferation • regulation of T cell proliferation • regulation of mononuclear cell proliferation • response to peptide • cellular response to interleukin-1 • response to cytokine • cellular response to cytokine stimulus • response to interleukin-1 • macrophage apoptotic process • myeloid cell apoptotic process • negative regulation of macrophage apoptotic process • regulation of macrophage apoptotic process • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • regulation of myeloid cell apoptotic process • biological process involved in interspecies interaction between organisms • host-mediated suppression of viral proces • host-mediated perturbation of viral transcription • host-mediated suppression of viral transcription • host-mediated perturbation of viral process • modulation of process of another organism • host-mediated perturbation of symbiont process • positive regulation of receptor signaling pathway via STAT • regulation of receptor signaling pathway via STAT • cell-cell adhesion mediated by integrin • positive regulation of cell adhesion mediated by integrin • regulation of cell adhesion mediated by integrin • regulation of cell-cell adhesion mediated by integrin • positive regulation of cell-cell adhesion mediated by integrin • cell adhesion mediated by integrin • neutrophil activation • myeloid leukocyte activation • granulocyte activation • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of defense response • regulation of chronic inflammatory response • chronic inflammatory response • defense response • regulation of inflammatory response • response to stress • regulation of response to stress • inflammatory response • cellular response to tumor necrosis factor • response to tumor necrosis factor • immune response • response to other organism • response to type II interferon • defense response to symbiont • cellular response to type II interferon • response to biotic stimulus • defense response to other organism • innate immune response • response to external biotic stimulus • humoral immune response • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • negative regulation of viral genome replication • negative regulation of viral process • response to virus • positive regulation of T cell chemotaxis • regulation of T cell chemotaxis • T cell chemotaxis • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • exocytosis • vesicle-mediated transport • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • positive regulation of immune response • positive regulation of innate immune response • regulation of innate immune response • positive regulation of defense response • regulation of immune response • cellular response to virus • chemokine (C-C motif) ligand 5 signaling pathway • positive regulation of cytosolic calcium ion concentration • response to sterol • response to cholesterol • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • calcium-mediated signaling • MAPK cascade • cellular defense response • cellular localization • monoatomic ion transmembrane transport • sarcoplasmic reticulum calcium ion transport • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • negative regulation of sequestering of calcium ion • maintenance of location in cell • monoatomic cation transmembrane transport • regulation of sequestering of calcium ion • release of sequestered calcium ion into cytosol by endoplasmic reticulum • calcium ion transmembrane import into cytosol • sequestering of calcium ion • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • cell surface • external side of plasma membrane • endosome • intracellular vesicle • cytoplasmic vesicle
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51681
Sequence	>7F1R_nogp_Chain_R L P P L Y S L V F I F G F V G N M L V I L I L I N C K R L K S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H A V F A L K A R T V T F G V V T S V I T W V V A V F A S L P N I I F T R S Q K C G L H Y T C S S H F P Y S Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C R N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G L N N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K F R N Y L L V F F Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6AKY	A	Protein	Chemokine	CCR5	Homo sapiens	-	Maraviroc	-	2.8	2018-10-24	doi.org/10.1021/acs.jmedchem.8b01077
	4MBS	A	Protein	Chemokine	CCR5	Homo sapiens	-	Maraviroc	-	2.71	2013-09-11	doi.org/10.1126/science.1241475
	6AKX	A	Protein	Chemokine	CCR5	Homo sapiens	-	A4R	-	2.8	2018-10-24	doi.org/10.1021/acs.jmedchem.8b01077
	5UIW	A	Protein	Chemokine	CCR5	Homo sapiens	5P7-CCL5	-	-	2.2	2017-06-28	doi.org/10.1016/j.immuni.2017.05.002
	7F1Q	A	Protein	Chemokine	CCR5	Homo sapiens	MIP-1a	-	Gi1/β1/γ2	2.9	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1Q (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	MIP-1a	-		2.9	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1R	A	Protein	Chemokine	CCR5	Homo sapiens	-	-	Gi1/β1/γ2	3	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1R (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	-	-		3	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1S	A	Protein	Chemokine	CCR5	Homo sapiens	-	-	Gi1/β1/γ2	2.8	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1S (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	-	-		2.8	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	7F1T	A	Protein	Chemokine	CCR5	Homo sapiens	MIP-1a	-	-	2.6	2021-07-14	doi.org/10.1038/s41467-021-24438-5
	6MEO	A	Protein	Chemokine	CCR5	Homo sapiens	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	-	-	3.9	2018-12-12	doi.org/10.1038/s41586-018-0804-9
	6MET	A	Protein	Chemokine	CCR5	Homo sapiens	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	-	-	4.5	2018-12-12	doi.org/10.1038/s41586-018-0804-9
	7O7F	A	Protein	Chemokine	CCR5	Homo sapiens	6P4-CCL5	-	Gi1/β1/γ1	3.15	2021-06-30	doi.org/10.1126/sciadv.abg8685
	7O7F (No Gprot)	A	Protein	Chemokine	CCR5	Homo sapiens	6P4-CCL5	-		3.15	2021-06-30	doi.org/10.1126/sciadv.abg8685

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