Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L55 5.2427
2R:R:L61 4.616526
3R:R:M64 5.8925426
4R:R:D66 7.53428
5R:R:I67 3.79427
6R:R:Y68 5.28833627
7R:R:D76 6.5625459
8R:R:Y108 8.98617
9R:R:F109 8.704515
10R:R:F112 6.978517
11R:R:F113 6.212517
12R:R:I116 3.45417
13R:R:F118 8.175647
14R:R:D125 7.0025428
15R:R:Y127 7.4775468
16R:R:V131 6.535467
17R:R:R140 4.015426
18R:R:W153 8.345449
19R:R:C178 3.955419
20R:R:F182 11.4575
21R:R:P206 6.2825419
22R:R:Y214 5.78714739
23R:R:I217 3.905438
24R:R:I240 4.118538
25R:R:Y244 5.17286719
26R:R:F247 3.936518
27R:R:W248 7.542519
28R:R:Y251 5.878517
29R:R:V254 2.38405
30R:R:T259 7.0175405
31R:R:Q261 2.585404
32R:R:H289 5.46519
33R:R:Y297 6.632509
34R:R:F304 4.04408
35R:R:L308 3.24406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M287 R:R:T284 16.04113.01NoNo086
2R:R:M287 R:R:V83 11.511112.17NoNo087
3R:R:C290 R:R:D76 18.09833.11NoYes089
4R:R:C290 R:R:F79 20.68065.59NoNo087
5R:R:W86 R:R:Y108 17.37068.68NoYes077
6R:R:F311 R:R:L53 11.86672.44NoNo044
7R:R:F311 R:R:I54 14.20835.02NoNo047
8R:R:I54 R:R:L308 23.46544.28NoYes076
9R:R:F299 R:R:L308 30.29334.87NoYes076
10R:R:F299 R:R:F304 34.79054.29NoYes078
11R:R:F304 R:R:K59 41.14246.2YesNo085
12R:R:D66 R:R:K59 43.341713.83YesNo085
13R:R:D66 R:R:L61 47.36295.43YesYes286
14R:R:I67 R:R:L61 56.03465.71YesYes276
15R:R:I67 R:R:Y68 68.75483.63YesYes277
16R:R:L122 R:R:Y68 98.26573.52NoYes097
17R:R:L122 R:R:Y297 1005.86NoYes099
18R:R:I119 R:R:Y297 92.76738.46NoYes089
19R:R:I119 R:R:Y244 93.32533.63NoYes089
20R:R:W248 R:R:Y244 69.16515.79YesYes199
21R:R:W248 R:R:Y251 85.4476.75YesYes197
22R:R:Y108 R:R:Y251 47.23712.98YesYes177
23R:R:N293 R:R:Y297 76.75896.98NoYes099
24R:R:H289 R:R:N293 74.80033.83YesNo099
25R:R:H289 R:R:W248 73.83749.52YesYes199
26R:R:D125 R:R:Y68 14.07166.9YesYes287
27R:R:T82 R:R:Y108 12.59446.24NoYes077
28R:R:L72 R:R:N293 19.85996.87NoNo099
29R:R:F112 R:R:F79 19.49344.29YesNo077
30R:R:W86 R:R:Y176 10.553713.5NoNo074
31R:R:C101 R:R:C178 11.08987.28NoYes099
32R:R:C178 R:R:T105 17.74811.69YesNo195
33R:R:F109 R:R:T105 53.61092.59YesNo155
34R:R:F109 R:R:Y108 35.797111.35YesYes157
35R:R:N98 R:R:Q102 18.43210.56NoNo037
36R:R:Q102 R:R:T167 29.36329.92NoNo075
37R:R:T105 R:R:T167 32.73886.28NoNo155
38R:R:N98 R:R:R168 14.76643.62NoNo034
39R:R:F109 R:R:F113 32.71697.5YesYes157
40R:R:I110 R:R:S160 11.02426.19NoNo057
41R:R:F112 R:R:I116 41.55275.02YesYes177
42R:R:I116 R:R:P206 12.23333.39YesYes179
43R:R:I120 R:R:P206 14.47098.47NoYes079
44R:R:I120 R:R:V209 13.5084.61NoNo076
45R:R:T123 R:R:V209 12.82964.76NoNo096
46R:R:R126 R:R:Y214 69.61374.12NoYes399
47R:R:R126 R:R:Y297 79.48358.23NoYes099
48R:R:I296 R:R:Y297 12.22233.63NoYes089
49R:R:V131 R:R:Y127 13.207112.62YesYes678
50R:R:T220 R:R:V131 31.44224.76NoYes057
51R:R:T220 R:R:V130 33.99173.17NoNo058
52R:R:I217 R:R:V130 36.53036.14YesNo088
53R:R:I217 R:R:Y214 62.51783.63YesYes389
54R:R:L161 R:R:P162 36.1914.93NoNo048
55R:R:K197 R:R:P162 38.64211.67NoNo038
56R:R:K197 R:R:Q194 44.03114.07NoNo035
57R:R:F109 R:R:N163 11.363418.12YesNo054
58R:R:F166 R:R:I165 28.00097.54NoNo053
59R:R:I165 R:R:L161 30.74191.43NoNo034
60R:R:F166 R:R:F182 14.027818.22NoYes755
61R:R:F166 R:R:W190 11.215720.04NoNo753
62R:R:H181 R:R:R168 11.08989.03NoNo044
63R:R:L255 R:R:Y251 13.28924.69NoYes067
64R:R:L255 R:R:T259 11.36342.95NoYes065
65R:R:L203 R:R:Y244 10.3023.52NoYes089
66R:R:I217 R:R:L221 25.63191.43YesNo088
67R:R:C224 R:R:R230 15.57616.96NoNo047
68R:R:L221 R:R:R230 23.04963.64NoNo087
69R:R:C224 R:R:N226 10.31291.57NoNo044
70R:R:I240 R:R:L236 12.97192.85YesNo088
71R:R:F247 R:R:H289 11.19934.53YesYes189
72R:R:T284 R:R:V281 16.56641.59NoNo065
73R:R:T282 R:R:V281 18.40461.59NoNo075
74R:R:T282 R:R:Y251 51.49913.75NoYes077
75R:R:T282 R:R:V254 33.57044.76NoYes075
76R:R:M279 R:R:V254 17.11891.52NoYes055
77R:R:M279 R:R:N258 15.22057.01NoNo054
78R:R:N258 R:R:Q261 13.49712.64NoYes044
79R:R:A278 R:R:L275 11.77923.15NoNo065
80R:R:A278 R:R:V254 13.49161.7NoYes065
81R:R:F112 R:R:I198 41.50343.77YesNo175
82R:R:F118 R:R:L72 18.69464.87YesNo079
83R:R:F112 R:R:W248 65.499510.02YesYes179
84R:R:F112 R:R:F113 46.006111.79YesYes177
85R:R:I116 R:R:Y244 30.36443.63YesYes179
86R:R:I198 R:R:Q194 40.01535.49NoNo055
87R:R:F113 R:R:S160 10.4996.61YesNo177
88R:R:T123 R:R:Y214 11.94336.24NoYes399
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7F1S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.95
Number of Linked Nodes 248
Number of Links 276
Number of Hubs 35
Number of Links mediated by Hubs 135
Number of Communities 8
Number of Nodes involved in Communities 53
Number of Links involved in Communities 70
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 51101
Length Of Smallest Path 3
Average Path Length 13.5796
Length of Longest Path 31
Minimum Path Strength 1.305
Average Path Strength 5.7011
Maximum Path Strength 18.235
Minimum Path Correlation 0.7
Average Path Correlation 0.915571
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 43.3055
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.395
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • virus receptor activity   • exogenous protein binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • phosphoric ester hydrolase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • phospholipase C activity   • phosphatidylinositol-4,5-bisphosphate phospholipase C activity   • phospholipase activity   • lipase activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • cytoskeletal protein binding   • actin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • chemokine (C-C motif) ligand 5 binding   • identical protein binding   • leukocyte apoptotic process   • regulation of programmed cell death   • macrophage apoptotic process   • negative regulation of leukocyte apoptotic process   • myeloid cell apoptotic process   • regulation of leukocyte apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • negative regulation of macrophage apoptotic process   • cell death   • negative regulation of apoptotic process   • regulation of macrophage apoptotic process   • inflammatory cell apoptotic process   • negative regulation of myeloid cell apoptotic process   • apoptotic process   • regulation of myeloid cell apoptotic process   • programmed cell death   • positive regulation of cytosolic calcium ion concentration   • immune response   • response to sterol   • response to cholesterol   • biological process involved in interspecies interaction between organisms   • response to other organism   • cellular response to lipopolysaccharide   • response to external stimulus   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • response to biotic stimulus   • cellular response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • calcium-mediated signaling   • MAPK cascade   • chemotaxis   • taxis   • locomotion   • cell chemotaxis   • dendritic cell chemotaxis   • dendritic cell migration   • leukocyte chemotaxis   • cell surface receptor signaling pathway   • defense response   • response to stress   • cellular defense response   • monoatomic ion transport   • monoatomic cation transport   • calcium ion transport   • metal ion transport   • inflammatory response   • cellular localization   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • monoatomic ion transmembrane transport   • sarcoplasmic reticulum calcium ion transport   • calcium ion homeostasis   • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • negative regulation of sequestering of calcium ion   • maintenance of location in cell   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • regulation of sequestering of calcium ion   • intracellular monoatomic ion homeostasis   • release of sequestered calcium ion into cytosol by endoplasmic reticulum   • calcium ion transmembrane import into cytosol   • sequestering of calcium ion   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • cellular homeostasis   • chemical homeostasis   • calcium ion transmembrane transport   • cell surface   • external side of plasma membrane   • endosome   • intracellular vesicle   • cytoplasmic vesicle
SCOP2Domain Identifier• Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP51681
Sequence
>7F1S_nogp_Chain_R
LPPLYSLVF IFGFVGNML VILILINCK RLKSMTDIY LLNLAISDL 
FFLLTVPFW AHYAFGNTM CQLLTGLYF IGFFSGIFF IILLTIDRY 
LAVVHAVFA LKARTVTFG VVTSVITWV VAVFASLPN IIFTRSQKE 
GLHYTCSSH FPYSQYQFW KNFQTLKIV ILGLVLPLL VMVICYSGI 
LKTLLRCRN EKKRHRAVR LIFTIMIVY FLFWAPYNI VLLLNTFQE 
FFGLNNCSS SNRLDQAMQ VTETLGMTH CCINPIIYA FVGEKFRNY 
LLVFFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6AKYAProteinChemokineCCR5Homo sapiens-Maraviroc-2.82018-10-24doi.org/10.1021/acs.jmedchem.8b01077
4MBSAProteinChemokineCCR5Homo sapiens-Maraviroc-2.712013-09-11doi.org/10.1126/science.1241475
6AKXAProteinChemokineCCR5Homo sapiens-A4R-2.82018-10-24doi.org/10.1021/acs.jmedchem.8b01077
5UIWAProteinChemokineCCR5Homo sapiens5P7-CCL5--2.22017-06-28doi.org/10.1016/j.immuni.2017.05.002
7F1QAProteinChemokineCCR5Homo sapiensMIP-1a-Gi1/β1/γ22.92021-07-14doi.org/10.1038/s41467-021-24438-5
7F1Q (No Gprot) AProteinChemokineCCR5Homo sapiensMIP-1a-2.92021-07-14doi.org/10.1038/s41467-021-24438-5
7F1RAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ232021-07-14doi.org/10.1038/s41467-021-24438-5
7F1R (No Gprot) AProteinChemokineCCR5Homo sapiens--32021-07-14doi.org/10.1038/s41467-021-24438-5
7F1SAProteinChemokineCCR5Homo sapiens--Gi1/β1/γ22.82021-07-14doi.org/10.1038/s41467-021-24438-5
7F1S (No Gprot) AProteinChemokineCCR5Homo sapiens--2.82021-07-14doi.org/10.1038/s41467-021-24438-5
7F1TAProteinChemokineCCR5Homo sapiensMIP-1a--2.62021-07-14doi.org/10.1038/s41467-021-24438-5
6MEOAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--3.92018-12-12doi.org/10.1038/s41586-018-0804-9
6METAProteinChemokineCCR5Homo sapiensEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4--4.52018-12-12doi.org/10.1038/s41586-018-0804-9
7O7FAProteinChemokineCCR5Homo sapiens6P4-CCL5-Gi1/β1/γ13.152021-06-30doi.org/10.1126/sciadv.abg8685
7O7F (No Gprot) AProteinChemokineCCR5Homo sapiens6P4-CCL5-3.152021-06-30doi.org/10.1126/sciadv.abg8685




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7F1S_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.